{"id":7834,"date":"2025-03-26T16:16:04","date_gmt":"2025-03-26T07:16:04","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/aga\/?p=7834"},"modified":"2025-03-26T16:30:08","modified_gmt":"2025-03-26T07:30:08","slug":"minonewtgt","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/aga\/minonewtgt\/","title":{"rendered":"\u30df\u30ce\u30ad\u30b7\u30b8\u30eb\u306f\u306a\u305c\u9aea\u306b\u52b9\u304f\u306e\uff1f\u6700\u65b0\u7814\u7a76\u3067\u308f\u304b\u3063\u305f\u7406\u7531"},"content":{"rendered":"\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\"><sup><a href=\"https:\/\/doi.org\/10.2147\/DDDT.S427612\">Shen, Y., Zhu, Y., Zhang, L., Sun, J., Xie, B., Zhang, H., &amp; Song, X. (2023). New Target for Minoxidil in the Treatment of Androgenetic Alopecia. <em>&amp;quot;Drug Design, Development and Therapy<\/em>, <em>17<\/em>, 2537\u20132547. https:\/\/doi.org\/10.2147\/DDDT.S427612<\/a><\/sup><\/p>\n\n\n\n<p class=\"has-text-align-center\"><sup><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>,<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>,<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">\u7537\u6027\u578b\u8131\u6bdb<\/a>\u75c7,\u767a\u6bdb,\u8584\u6bdb\u6cbb\u7642,\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53,AR,CYP17A1,CYP19A1,DHT,\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3,\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9,\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u85ac\u7406\u5b66,\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR,\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8,ELISA,\u6bdb\u4e73\u982d\u7d30\u80de,\u514d\u75ab\u86cd\u5149\u67d3\u8272,<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306e\u4ed5\u7d44\u307f,<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306e\u52b9\u679c,\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">\u7537\u6027\u578b\u8131\u6bdb<\/a>\u75c7\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\uff09\u306b\u4f5c\u7528\u3059\u308b\u4ed5\u7d44\u307f\u3092\u63a2\u308b<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u306f\u3058\u3081\u306b\uff1a<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">\u7537\u6027\u578b\u8131\u6bdb<\/a>\u75c7\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\uff09\u3068\u306f\uff1f \u306a\u305c<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u4f7f\u308f\u308c\u308b\u306e\u304b\uff1f<\/h3>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">\u7537\u6027\u578b\u8131\u6bdb<\/a>\u75c7\uff08Androgenetic Alopecia\u3001\u4ee5\u4e0b <a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\uff09\u306f\u3001\u7537\u6027\u30fb\u5973\u6027\u554f\u308f\u305a\u6700\u3082\u4e00\u822c\u7684\u306a\u8131\u6bdb\u75c7\u3067\u3001\u3059\u3079\u3066\u306e\u8131\u6bdb\u75c7\u306e\u7d0495\uff05\u3092\u5360\u3081\u308b\u3068\u3055\u308c\u307e\u3059\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u306f\u3001\u982d\u9802\u90e8\u3084\u524d\u982d\u90e8\u3092\u4e2d\u5fc3\u306b\u5de6\u53f3\u5bfe\u79f0\u306b\u5f90\u3005\u306b\u9aea\u304c\u7d30\u304f\u3001\u77ed\u304f\u3001\u307e\u3070\u3089\u306b\u306a\u3063\u3066\u3044\u304f\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002\u9032\u884c\u3068\u3068\u3082\u306b\u6bdb\u5305\uff08\u3082\u3046\u307b\u3046\uff1a\u9aea\u306e\u6bdb\u3092\u751f\u307f\u51fa\u3059\u76ae\u819a\u306e\u5668\u5b98\uff09\u304c\u5c0f\u3055\u304f\u306a\u308a\u3001\u6700\u7d42\u7684\u306b\u9aea\u306e\u6210\u9577\u304c\u6b62\u307e\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\uff08Minoxidil\uff09\u306f\u3082\u3068\u3082\u3068\u8840\u5727\u3092\u4e0b\u3052\u308b\u5185\u670d\u85ac\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u305f\u85ac\u3067\u3059\u304c\u3001\u526f\u4f5c\u7528\u3068\u3057\u3066\u4f53\u6bdb\u304c\u6fc3\u304f\u306a\u308b\u73fe\u8c61\u304c\u898b\u3089\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u767a\u6bdb\u52b9\u679c\u304c\u6ce8\u76ee\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u30011988\u5e74\u306b\u5916\u7528\u85ac\u3068\u3057\u3066<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u9aea\u306e\u6bdb\u306b\u3069\u3046\u4f5c\u7528\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u6b63\u78ba\u306a\u4ed5\u7d44\u307f\u306f\u9577\u3089\u304f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/AGA.jpg\" alt=\"\u7121\u6599\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067AGA\u306e\u9032\u884c\u5ea6\u3092\u30c1\u30a7\u30c3\u30af\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u3053\u308c\u307e\u3067\u306b\u77e5\u3089\u308c\u3066\u3044\u305f<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306e\u4f5c\u7528\uff1a\u8907\u96d1\u306b\u7d61\u307f\u5408\u3046\u4ed5\u7d44\u307f<\/h3>\n\n\n\n<p>\u904e\u53bb\u306e\u7814\u7a76\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306e\u4f5c\u7528\u6a5f\u5e8f\u3068\u3057\u3066\u3044\u304f\u3064\u304b\u306e\u4eee\u8aac\u304c\u7acb\u3066\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306fWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\uff08Wnt\/\u03b2-catenin signaling pathway\uff09\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u5185\u306e\u60c5\u5831\u4f1d\u9054\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u6bdb\u5305\u306e\u6210\u9577\u3092\u4fc3\u9032\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u306f\u3001\u6bdb\u5305\u306e\u767a\u9054\u3084\u518d\u751f\u306b\u304a\u3044\u3066\u6975\u3081\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/29687138_s.jpg\" alt=\"\" class=\"wp-image-7812\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29687138_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29687138_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29687138_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306f\u6bdb\u5468\u671f\uff08hair cycle\uff09\u306e\u4e2d\u3067\u3082\u300c\u6210\u9577\u671f\uff08anagen phase\uff09\u300d\u3092\u5ef6\u9577\u3059\u308b\u3053\u3068\u3067\u3001\u9aea\u304c\u9577\u304f\u3001\u592a\u304f\u6210\u9577\u3059\u308b\u6642\u9593\u3092\u78ba\u4fdd\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7523\u6bdb\u306e\u3088\u3046\u306a\u7d30\u304f\u77ed\u3044\u6bdb\uff08vellus hair\uff09\u3092\u3001\u592a\u304f\u3057\u3063\u304b\u308a\u3057\u305f\u6bdb\uff08terminal hair\uff09\u3078\u3068\u5909\u5316\u3055\u305b\u308b\u52b9\u679c\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306f\u307e\u305f\u3001\u8840\u7ba1\u65b0\u751f\uff08angiogenesis\uff09\u3092\u4fc3\u3059\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50\uff08vascular endothelial growth factor\uff1aVEGF\uff09\u306e\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u6bdb\u5305\u3078\u306e\u8840\u6d41\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3078\u306e\u4f5c\u7528\u3082\u3042\u308a\u3001\u7d30\u80de\u819c\u306e\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\uff08potassium channel\uff09\u3092\u958b\u304d\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\uff08calcium\uff09\u306e\u6d41\u5165\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u751f\u5b58\u3084\u5897\u6b96\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\uff08epidermal growth factor\uff1aEGF\uff09\u306b\u3088\u308b\u6bdb\u5305\u306e\u6210\u9577\u6291\u5236\u4f5c\u7528\u3092\u6253\u3061\u6d88\u3059\u52b9\u679c\u304c\u3042\u308b\u3068\u63a8\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/23443899_s.jpg\" alt=\"\u5927\u4e08\u592b\u3084\u3067\" class=\"wp-image-7731\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/23443899_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/23443899_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/23443899_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f31\uff08interleukin-1\uff1aIL-1\uff09\u306e\u767a\u73fe\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u3001\u6297\u708e\u75c7\u4f5c\u7528\uff08anti-inflammatory effect\uff09\u3082\u767a\u63ee\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066\u91cd\u8981\u306a\u306e\u304c\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u81ea\u4f53\u306f\u6d3b\u6027\u3092\u6301\u305f\u305a\u3001\u30b9\u30eb\u30db\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08sulfotransferase\uff09<strong>\u3068\u3044\u3046\u9175\u7d20\u306b\u3088\u3063\u3066<\/strong><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u786b\u9178\u5869\uff08minoxidil sulfate\uff09\u3068\u3044\u3046\u5f62\u306b\u4ee3\u8b1d\u3055\u308c\u3066\u306f\u3058\u3081\u3066\u6d3b\u6027\u3092\u6301\u3064\u70b9\u3067\u3059\u3002\u3053\u306e\u4ee3\u8b1d\u306f\u6bdb\u5305\u306e\u5916\u6bdb\u6839\u9798\uff08outer root sheath\uff09\u3068\u3044\u3046\u90e8\u4f4d\u3067\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306b\u306f\u3055\u307e\u3056\u307e\u306a\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u3067\u3082\u306a\u304a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u306b\u5bfe\u3059\u308b\u305d\u306e\u6cbb\u7642\u52b9\u679c\u306e\u3059\u3079\u3066\u3092\u8aac\u660e\u3059\u308b\u306b\u306f\u4e0d\u5341\u5206\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u3053\u306e\u7814\u7a76\u306e\u76ee\u7684<\/h3>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u306b\u5bfe\u3057\u3066\u3069\u306e\u3088\u3046\u306b\u4f5c\u7528\u3059\u308b\u304b\u3092\u3001\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u85ac\u7406\u5b66\uff08network pharmacology\uff09<strong>\u3068<\/strong>\u5b9f\u9a13\u7684\u624b\u6cd5\uff08experimental techniques\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u65b0\u305f\u306a\u6a19\u7684\u3092\u898b\u51fa\u3057\u3001\u3088\u308a\u6df1\u304f\u7406\u89e3\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u30db\u30eb\u30e2\u30f3\u95a2\u9023\u306e\u9175\u7d20\u3084\u53d7\u5bb9\u4f53\u306b\u5bfe\u3057\u3066\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u3069\u306e\u3088\u3046\u306b\u50cd\u304f\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306e\u30db\u30eb\u30e2\u30f3\u8abf\u7bc0\u4f5c\u7528<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u8840\u4e2d\u30db\u30eb\u30e2\u30f3\u3088\u308a\u3082\u6bdb\u5305\u5185\u30db\u30eb\u30e2\u30f3\u304c\u91cd\u8981<\/h3>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u60a3\u8005\u3067\u306f\u3001\u8840\u6db2\u4e2d\u306e\u7537\u6027\u30db\u30eb\u30e2\u30f3\uff08\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\uff09\u306e\u5024\u306f\u6b63\u5e38\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u4e00\u65b9\u3001\u6bdb\u5305\u5185\u3067\u306e\u5c40\u6240\u7684\u306a\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u4ee3\u8b1d\u304c\u3001\u3088\u308a\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u6bdb\u5305\u5185\u3067\u306f\u30015\u03b1-\u9084\u5143\u9175\u7d20\uff085\u03b1-reductase\uff09<strong>\u306b\u3088\u3063\u3066<\/strong>\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08testosterone\uff09<strong>\u304c\u3088\u308a\u5f37\u529b\u306a\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u3067\u3042\u308b<\/strong>\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08dihydrotestosterone\uff1aDHT\uff09<strong>\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002\u3053\u306eDHT\u304c<\/strong>\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08androgen receptor\uff1aAR\uff09\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u6bdb\u5305\u304c\u840e\u7e2e\u3057\u3001\u9aea\u306e\u6bdb\u304c\u7d30\u304f\u306a\u308b\u300c\u30df\u30cb\u30c1\u30e5\u30a2\u5316\uff08miniaturization\uff09\u300d\u304c\u9032\u884c\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/28599892_s.jpg\" alt=\"\" class=\"wp-image-7660\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28599892_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28599892_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28599892_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u65b0\u305f\u306b\u6a19\u7684\u3068\u3059\u308b\u9175\u7d20\uff1aCYP17A1\u3068CYP19A1<\/h3>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u6b21\u306e2\u3064\u306e\u30db\u30eb\u30e2\u30f3\u5408\u6210\u9175\u7d20\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u65b0\u305f\u306b\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>CYP17A1\uff0817\u03b1-\u30d2\u30c9\u30ed\u30ad\u30b7\u30e9\u30fc\u30bc\/17,20-\u30ea\u30a2\u30fc\u30bc\uff09\u306f\u3001\u30d7\u30ec\u30b0\u30cd\u30ce\u30ed\u30f3\uff08pregnenolone\uff09\u3092\u30c7\u30d2\u30c9\u30ed\u30a8\u30d4\u30a2\u30f3\u30c9\u30ed\u30b9\u30c6\u30ed\u30f3\uff08DHEA\uff09\u306b\u5909\u63db\u3057\u3001\u305d\u306e\u5f8c\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3084DHT\u3078\u3068\u3064\u306a\u304c\u308b\u7d4c\u8def\u306e\u91cd\u8981\u306a\u9175\u7d20\u3067\u3059\u3002\u3053\u306e\u9175\u7d20\u306e\u767a\u73fe\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u3001\u6bdb\u5305\u5185\u3067\u306eDHT\u7523\u751f\u3092\u6e1b\u3089\u3059\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>CYP19A1\uff08\u30a2\u30ed\u30de\u30bf\u30fc\u30bc\uff1aaromatase\uff09<strong>\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092<\/strong>\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\uff08estradiol\uff1aE2\uff09\u3068\u3044\u3046\u5973\u6027\u30db\u30eb\u30e2\u30f3\u306b\u5909\u63db\u3059\u308b\u9175\u7d20\u3067\u3059\u3002\u3053\u306e\u6d3b\u6027\u304c\u4e0a\u6607\u3059\u308b\u3068\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u91cf\u304c\u6e1b\u308a\u3001\u76f8\u5bfe\u7684\u306b\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u304c\u5897\u52a0\u3057\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u9aea\u306b\u3068\u3063\u3066\u597d\u307e\u3057\u3044\u74b0\u5883\u304c\u4f5c\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/AGA.jpg\" alt=\"\u7121\u6599\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067AGA\u306e\u9032\u884c\u5ea6\u3092\u30c1\u30a7\u30c3\u30af\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u9175\u7d20\u306e\u300c\u767a\u73fe\u91cf\u300d\u3068\u300c\u6d3b\u6027\u300d\u306f\u7570\u306a\u308b<\/h3>\n\n\n\n<p>CYP19A1\u306b\u3064\u3044\u3066\u8208\u5473\u6df1\u3044\u306e\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\uff08mRNA\u91cf\uff09\u304c\u5897\u52a0\u3057\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u306b\u306f\u6709\u610f\u306a\u5909\u5316\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304b\u3089\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u3078\u306e\u5909\u63db\u304c\u660e\u3089\u304b\u306b\u5897\u52a0\u3057\u3066\u3044\u305f\u3053\u3068\u304b\u3089\u3001\u9175\u7d20\u306e\u300c\u6d3b\u6027\uff08activity\uff09\u300d\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u9175\u7d20\u81ea\u4f53\u306e\u91cf\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u306e\u69cb\u9020\u5909\u5316\u3084\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u5236\u5fa1\u3001\u3042\u308b\u3044\u306f\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306a\u3069\u306b\u3088\u308a\u6d3b\u6027\u304c\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">DHT\u3068E2\u306e\u6bd4\u7387\u304c\u30ab\u30ae\uff1f<\/h3>\n\n\n\n<p>DHT\u3068E2\u306e\u7d76\u5bfe\u91cf\u3088\u308a\u3082\u3001\u305d\u306e\u6bd4\u7387\uff08DHT\/E2 ratio\uff09\u304c\u6bdb\u5305\u306b\u304a\u3051\u308b\u74b0\u5883\u306e\u6c7a\u5b9a\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5c40\u6240\u7684\u306bDHT\u306e\u6bd4\u7387\u304c\u4e0b\u304c\u308a\u3001E2\u304c\u76f8\u5bfe\u7684\u306b\u9ad8\u307e\u308b\u3053\u3068\u3067\u3001\u6bdb\u5305\u306e\u6210\u9577\u3092\u652f\u3048\u308b\u3088\u308a\u826f\u3044\u30db\u30eb\u30e2\u30f3\u74b0\u5883\u304c\u4f5c\u3089\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5168\u8eab\u306e\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u8b70\u8ad6\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u76ae\u819a\u3084\u6bdb\u5305\u5185\u3067\u5408\u6210\u3055\u308c\u308b\u5c40\u6240\u7684\u306a\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306f\u3001\u767a\u6bdb\u306b\u826f\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"385\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/32055915_s.jpg\" alt=\"\" class=\"wp-image-7580\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32055915_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32055915_s-300x180.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32055915_s-485x292.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u306b\u7528\u3044\u3089\u308c\u305f\u65b9\u6cd5<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u85ac\u7406\u5b66\u306b\u3088\u308b\u89e3\u6790<\/h3>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u907a\u4f1d\u5b50\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u53ef\u8996\u5316\u3057\u3001\u4f5c\u7528\u7d4c\u8def\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u85ac\u7406\u5b66\uff08network pharmacology\uff09\u306e\u624b\u6cd5\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u6a19\u7684\u4e88\u6e2c<\/h4>\n\n\n\n<p><strong>SwissTargetPrediction<\/strong>\u3001<strong>DrugBank<\/strong>\u3001<strong>PharmMapper<\/strong>\u3068\u3044\u3063\u305f\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u7528\u3044\u3066\u3001\u30d2\u30c8\uff08Homo sapiens\uff09\u3092\u5bfe\u8c61\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306e\u6a19\u7684\u5019\u88dc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4e88\u6e2c\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u306fCytoscape\uff08\u30b5\u30a4\u30c8\u30b9\u30b1\u30fc\u30d7\uff09\u3068\u3044\u3046\u53ef\u8996\u5316\u30bd\u30d5\u30c8\u3092\u4f7f\u3063\u3066\u6574\u7406\u3055\u308c\u3001\u85ac\u5264\u3068\u305d\u306e\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u95a2\u4fc2\uff08\u30ce\u30fc\u30c9\u3068\u30a8\u30c3\u30b8\uff09\u3068\u3057\u3066\u8868\u73fe\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u53ce\u96c6<\/h4>\n\n\n\n<p>\u300candrogenetic alopecia\u300d\u3068\u3044\u3046\u691c\u7d22\u8a9e\u3067\u3001<strong>GeneCards<\/strong>\u304a\u3088\u3073OMIM\uff08Online Mendelian Inheritance in Man\uff09\u304b\u3089414\u500b\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u95a2\u9023\u907a\u4f1d\u5b50\u3092\u53ce\u96c6\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/24978387_s.jpg\" alt=\"\u3082\u307f\u3082\u307f\" class=\"wp-image-7716\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/24978387_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/24978387_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/24978387_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">\u30bf\u30f3\u30d1\u30af\u8cea\u76f8\u4e92\u4f5c\u7528\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08PPI network\uff09\u3068\u4e2d\u5fc3\u6027\u89e3\u6790<\/h4>\n\n\n\n<p>\u5171\u6709\u3055\u308c\u308b\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u57fa\u306b\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u76f8\u4e92\u4f5c\u7528\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08protein-protein interaction\uff1aPPI\uff09\u3092Cytoscape\u3068\u305d\u306e\u30d7\u30e9\u30b0\u30a4\u30f3\uff08NCA\u304a\u3088\u3073cytoHubba\uff09\u3092\u4f7f\u3063\u3066\u69cb\u7bc9\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4e2d\u5fc3\u6027\u89e3\u6790\u3067\u306f\u3001<strong>\u6b21\u6570\uff08degree\uff09<\/strong>\u3001<strong>\u5a92\u4ecb\u4e2d\u5fc3\u6027\uff08betweenness\uff09<\/strong>\u3001\u8fd1\u63a5\u4e2d\u5fc3\u6027\uff08closeness\uff09\u306a\u3069\u306e\u6307\u6a19\u3092\u7528\u3044\u3066\u3001\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u4e2d\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u62bd\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">GO\u89e3\u6790\u3068KEGG\u7d4c\u8def\u89e3\u6790<\/h4>\n\n\n\n<p>DAVID\uff08Database for Annotation, Visualization, and Integrated Discovery\uff09\u3092\u4f7f\u7528\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GO\uff08Gene Ontology\uff09\u89e3\u6790<\/strong>\uff1a\u7d30\u80de\u5185\u306e\u4f4d\u7f6e\uff08cellular component\uff09\u3001\u5206\u5b50\u6a5f\u80fd\uff08molecular function\uff09\u3001\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\uff08biological process\uff09\u306b\u5206\u985e\u3002<\/li>\n\n\n\n<li><strong>KEGG\uff08Kyoto Encyclopedia of Genes and Genomes\uff09\u7d4c\u8def\u89e3\u6790<\/strong>\uff1aMAPK\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u30b7\u30b0\u30ca\u30eb\u306a\u3069\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/AGA.jpg\" alt=\"\u7121\u6599\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067AGA\u306e\u9032\u884c\u5ea6\u3092\u30c1\u30a7\u30c3\u30af\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u5206\u5b50\u30c9\u30c3\u30ad\u30f3\u30b0\u89e3\u6790<\/h3>\n\n\n\n<p>\u5206\u5b50\u30c9\u30c3\u30ad\u30f3\u30b0\uff08molecular docking\uff09\u3068\u306f\u3001\u85ac\u5264\u3068\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3069\u306e\u3088\u3046\u306b\u7d50\u5408\u3059\u308b\u304b\u3092\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u4e0a\u3067\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3059\u308b\u6280\u8853\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7acb\u4f53\u69cb\u9020\u306f<strong>RCSB-PDB\uff08Protein Data Bank\uff09\u304b\u3089\u53d6\u5f97\u3057\u3001AutoDock 4.2\u3001ChemBioDraw 3D\u3001\u304a\u3088\u3073Molegro Virtual Docker<\/strong>\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u7d50\u5408\u30a8\u30cd\u30eb\u30ae\u30fc\uff08binding energy\uff09\u304c\u221210\u4ee5\u4e0b\u3067\u3042\u308c\u3070\u3001\u9ad8\u3044\u89aa\u548c\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>AR\uff08\u221221.65\uff09\u3001CYP17A1\uff08\u221218.23\uff09\u3001CYP19A1\uff08\u221214.32\uff09\u306f\u7279\u306b\u7d50\u5408\u304c\u5f37\u304f\u3001\u6709\u529b\u306a\u6a19\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2024\/06\/27532308_s.jpg\" alt=\"\u8584\u6bdb\u6cbb\u7642\u306e\u8a3a\u65ad\u3092\u3059\u308b\u533b\u5e2b\" class=\"wp-image-7464\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2024\/06\/27532308_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2024\/06\/27532308_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2024\/06\/27532308_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b9f\u9a13\u306b\u3088\u308b\u691c\u8a3c<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u30d2\u30c8\u6bdb\u4e73\u982d\u7d30\u80de\uff08DPC\uff09\u306e\u57f9\u990a\u3068\u85ac\u5264\u51e6\u7406<\/h3>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306e\u52b9\u679c\u3092\u5b9f\u969b\u306e\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u30d2\u30c8\u6bdb\u4e73\u982d\u7d30\u80de\uff08dermal papilla cells\u3001DPC\uff09\u3068\u547c\u3070\u308c\u308b\u3001\u9aea\u306e\u6210\u9577\u306b\u91cd\u8981\u306a\u7d30\u80de\u3092\u7528\u3044\u3066\u5b9f\u9a13\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u4f7f\u7528\u3055\u308c\u305f\u7d30\u80de\u306fCTCC-106-HUM\u3068\u3044\u3046\u7d30\u80de\u682a\u3067\u3001\u901a\u5e38\u306e\u7d30\u80de\u57f9\u990a\u6db2\u3067\u3042\u308bDMEM\uff08Dulbecco\u2019s Modified Eagle Medium\uff09<strong>\u306b\u300110%\u306e<\/strong>FBS\uff08fetal bovine serum\uff1a\u80ce\u5150\u30a6\u30b7\u8840\u6e05\uff09\u304a\u3088\u30731%\u306e\u6297\u751f\u7269\u8cea\u3092\u52a0\u3048\u305f\u57f9\u5730\u3067\u57f9\u990a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u7d30\u80de\u304c80%\u306e\u5bc6\u5ea6\uff08\u30b3\u30f3\u30d5\u30eb\u30a8\u30f3\u30b9\uff09\u306b\u9054\u3057\u305f\u6642\u70b9\u3067\u3001\u4ee5\u4e0b\u306e2\u3064\u306e\u6761\u4ef6\u306748\u6642\u9593\u57f9\u990a\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u307f\u6dfb\u52a0\uff0810 nM\uff09\uff1a\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4<\/li>\n\n\n\n<li>\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff0810 nM\uff09\uff0b<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\uff08100 nM\uff09\uff1a\u51e6\u7f6e\u7fa4<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6fc3\u5ea6\u306f\u3001\u904e\u53bb\u306e\u7814\u7a76\u3084\u7d30\u80de\u306e\u751f\u5b58\u7387\u3092\u8a55\u4fa1\u3059\u308bCCK-8\u30a2\u30c3\u30bb\u30a4\uff08Cell Counting Kit-8\uff09\u306b\u57fa\u3065\u3044\u3066\u8a2d\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/32019046_s.jpg\" alt=\"\u5065\u5eb7\u306a\u4eba\" class=\"wp-image-7560\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32019046_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32019046_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32019046_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6e2c\u5b9a\uff08RT-PCR\uff09<\/h3>\n\n\n\n<p>\u7d30\u80de\u304b\u3089RNA\u3092\u62bd\u51fa\u3057\u3001\u9006\u8ee2\u5199\uff08reverse transcription\uff09\u306b\u3088\u3063\u3066cDNA\u306b\u5909\u63db\u3057\u305f\u5f8c\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\uff08polymerase chain reaction\uff09\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002\u5bfe\u8c61\u907a\u4f1d\u5b50\u306b\u306fAR\u3001CYP17A1\u3001CYP19A1\u304c\u542b\u307e\u308c\u3001GAPDH\uff08glyceraldehyde-3-phosphate dehydrogenase\uff09\u304c\u5185\u90e8\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff08\u767a\u73fe\u306e\u57fa\u6e96\uff09\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u306e\u6e2c\u5b9a\uff08\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\uff09<\/h3>\n\n\n\n<p>\u6b21\u306b\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30d9\u30eb\u3067\u306e\u5909\u5316\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\uff08Western blot\uff09\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u307e\u305a\u7d30\u80de\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u62bd\u51fa\u3057\u3001SDS-PAGE\uff08sodium dodecyl sulfate polyacrylamide gel electrophoresis\uff09\u3068\u3044\u3046\u65b9\u6cd5\u3067\u5206\u96e2\u3057\u305f\u5f8c\u3001\u819c\u306b\u8ee2\u5199\uff08\u30c8\u30e9\u30f3\u30b9\u30d5\u30a1\u30fc\uff09\u3057\u3066\u3001AR\u3001CYP17A1\u3001CYP19A1\u3001\u304a\u3088\u3073\u03b2-\u30a2\u30af\u30c1\u30f3\uff08internal control\uff09\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3067\u691c\u51fa\u3057\u307e\u3057\u305f\u3002\u7d50\u679c\u306e\u5b9a\u91cf\u306b\u306fImageJ\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/AGA.jpg\" alt=\"\u7121\u6599\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067AGA\u306e\u9032\u884c\u5ea6\u3092\u30c1\u30a7\u30c3\u30af\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30db\u30eb\u30e2\u30f3\u6fc3\u5ea6\u306e\u6e2c\u5b9a\uff08ELISA\uff09<\/h3>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\uff08\u30b9\u30fc\u30d1\u30fc\u30ca\u30bf\u30f3\u30c8\uff09\u304bDHT\uff08\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff09<strong>\u304a\u3088\u3073<\/strong>E2\uff08\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\uff09\u306e\u6fc3\u5ea6\u3092\u6e2c\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001ELISA\uff08enzyme-linked immunosorbent assay\uff09\u30ad\u30c3\u30c8\u3092\u7528\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001<strong>CYP19A1\u306e\u6d3b\u6027<\/strong>\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304cE2\u3078\u3069\u308c\u3060\u3051\u5909\u63db\u3055\u308c\u305f\u304b\u306b\u57fa\u3065\u3044\u3066\u7b97\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u514d\u75ab\u86cd\u5149\u67d3\u8272\u306b\u3088\u308b\u89b3\u5bdf\uff08Immunofluorescence\uff09<\/h3>\n\n\n\n<p>\u6700\u5f8c\u306b\u3001\u7d30\u80de\u5185\u306e\u5404\u9175\u7d20\u3084\u53d7\u5bb9\u4f53\u306e\u5206\u5e03\u3068\u767a\u73fe\u3092\u8996\u899a\u7684\u306b\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u514d\u75ab\u86cd\u5149\u67d3\u8272\uff08immunofluorescence\uff09<strong>\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u7d30\u80de\u306f\u56fa\u5b9a\u5f8c\u3001\u6d78\u900f\u51e6\u7406\u3068\u30d6\u30ed\u30c3\u30ad\u30f3\u30b0\u3092\u7d4c\u3066\u3001AR\u3001CYP17A1\u3001CYP19A1\u306b\u5bfe\u3059\u308b\u4e00\u6b21\u6297\u4f53\u3067\u4e00\u6669\u53cd\u5fdc\u3055\u305b\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001\u86cd\u5149\u8272\u7d20Alexa Fluor 488\u304c\u7d50\u5408\u3057\u305f\u4e8c\u6b21\u6297\u4f53\u3092\u4f7f\u3063\u3066\u6a19\u8b58\u3057\u3001\u6838\u306f<\/strong>DAPI\uff084\u2019,6-diamidino-2-phenylindole\uff09\u3067\u9752\u8272\u306b\u67d3\u8272\u3057\u307e\u3057\u305f\u3002\u86cd\u5149\u9855\u5fae\u93e1\u3092\u7528\u3044\u3066\u67d3\u8272\u30d1\u30bf\u30fc\u30f3\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b9f\u9a13\u7d50\u679c<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6a19\u7684\u4e88\u6e2c\u3068\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u89e3\u6790\u306e\u7d50\u679c<\/h3>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306b\u5bfe\u3059\u308b\u6a19\u7684\u3068\u3057\u3066\u3001\u307e\u305a100\u500b\u306e\u5019\u88dc\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4e88\u6e2c\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5185\u8a33\u306f\u3001\u9175\u7d20\u304c20%\u3001\u30ad\u30ca\u30fc\u30bc\u304c23%\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u304c14%\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u3092Cytoscape\u3067\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001878\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u3068\u306e\u95a2\u9023\u3092\u6301\u3061\u3001\u305d\u306e\u4e2d\u304b\u3089\u3055\u3089\u306b59\u500b\u306e\u91cd\u8981\u306a\u30ce\u30fc\u30c9\uff08\u7d50\u7bc0\u70b9\uff09\u304c\u62bd\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"451\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/28740373_s.jpg\" alt=\"\u591a\u304f\u306e\u8981\u56e0\u304c\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\" class=\"wp-image-7781\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28740373_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28740373_s-300x211.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28740373_s-485x342.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p>GO\u89e3\u6790\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u304c\u4e3b\u306b\u7d30\u80de\u819c\u4e0a\u306e\u30e1\u30f3\u30d6\u30ec\u30fc\u30f3\u30e9\u30d5\u30c8\uff08membrane raft\uff09<strong>\u3084<\/strong>\u30d5\u30a9\u30fc\u30ab\u30eb\u30a2\u30c9\u30d2\u30fc\u30b8\u30e7\u30f3\uff08focal adhesion\uff09\u306b\u5b58\u5728\u3057\u3001\u30ad\u30ca\u30fc\u30bc\u7d50\u5408\uff08kinase binding\uff09\u3084\u9175\u7d20\u6d3b\u6027\u3068\u3044\u3063\u305f\u5206\u5b50\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3001\u30db\u30eb\u30e2\u30f3\u5fdc\u7b54\u3084\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068\u3044\u3063\u305f\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>KEGG\u7d4c\u8def\u89e3\u6790\u3067\u306f\u3001MAPK\uff08mitogen-activated protein kinase\uff09\u7d4c\u8def\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u7d4c\u8def\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u7d4c\u8def\u306a\u3069\u304c\u6d6e\u304b\u3073\u4e0a\u304c\u308a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u30db\u30eb\u30e2\u30f3\u95a2\u9023\u306e\u30b7\u30b0\u30ca\u30eb\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5206\u5b50\u30c9\u30c3\u30ad\u30f3\u30b0\u306e\u7d50\u679c<\/h3>\n\n\n\n<p>\u30c9\u30c3\u30ad\u30f3\u30b0\u30b9\u30b3\u30a2\u304b\u3089\u3001AR\uff08\u221221.65\uff09\u3001CYP17A1\uff08\u221218.23\uff09\u3001CYP19A1\uff08\u221214.32\uff09\u304c\u7279\u306b\u9ad8\u3044\u7d50\u5408\u89aa\u548c\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u5206\u304b\u308a\u3001\u3053\u308c\u3089\u306e\u5206\u5b50\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u6cbb\u7642\u306b\u304a\u3051\u308b\u6709\u529b\u306a\u30bf\u30fc\u30b2\u30c3\u30c8\u3067\u3042\u308b\u3053\u3068\u304c\u518d\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u3053\u308c\u3089\u306e\u5206\u5b50\u306e\u6d3b\u6027\u3092\u76f4\u63a5\u8abf\u7bc0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/AGA.jpg\" alt=\"\u7121\u6599\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067AGA\u306e\u9032\u884c\u5ea6\u3092\u30c1\u30a7\u30c3\u30af\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304cAR\u3092\u6291\u5236\u3059\u308b<\/h3>\n\n\n\n<p>RT-PCR\u304a\u3088\u3073\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u306e\u7d50\u679c\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u3092\u6295\u4e0e\u3057\u305f\u7fa4\u3067\u306f\u3001AR\u306emRNA\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u91cf\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3057\u305f\u3002AR\u306f\u6bdb\u4e73\u982d\u7d30\u80de\u306b\u9ad8\u304f\u767a\u73fe\u3057\u3066\u304a\u308a\u3001DHT\u3068\u306e\u7d50\u5408\u306b\u3088\u3063\u3066<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u306e\u9032\u884c\u306b\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u3053\u306e\u6291\u5236\u52b9\u679c\u306f\u3001DHT\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u4e0b\u3052\u3001\u6bdb\u5305\u306e\u840e\u7e2e\u3092\u6291\u3048\u308b\u52b9\u679c\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304cCYP17A1\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b<\/h3>\n\n\n\n<p>\u540c\u69d8\u306b\u3001CYP17A1\u306e\u907a\u4f1d\u5b50\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3082<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306b\u3088\u3063\u3066\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002CYP17A1\u306fDHEA\u304b\u3089\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u305d\u3057\u3066DHT\u3078\u3068\u81f3\u308b\u7d4c\u8def\u306e\u4e2d\u6838\u306b\u3042\u308b\u9175\u7d20\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u304c\u6291\u3048\u3089\u308c\u308b\u3053\u3068\u3067\u5c40\u6240\u7684\u306aDHT\u306e\u7523\u751f\u304c\u6e1b\u5c11\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u540c\u69d8\u306e\u52b9\u679c\u304c\u77e5\u3089\u308c\u308b\u5916\u7528\u30b1\u30c8\u30b3\u30ca\u30be\u30fc\u30eb\u3068\u985e\u4f3c\u3057\u305f\u4f5c\u7528\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/32147407_s.jpg\" alt=\"\u925b\u7b46\" class=\"wp-image-7829\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32147407_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32147407_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32147407_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">CYP19A1\u306e\u6d3b\u6027\u304c\u4e0a\u6607\u3059\u308b<\/h3>\n\n\n\n<p>CYP19A1\u306b\u3064\u3044\u3066\u306f\u3001mRNA\u306e\u767a\u73fe\u304c\u7d041.84\u500d\u306b\u5897\u52a0\u3057\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u306f\u6709\u610f\u306a\u5909\u5316\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001ELISA\u3067\u6e2c\u5b9a\u3057\u305f\u30db\u30eb\u30e2\u30f3\u6fc3\u5ea6\u3067\u306f\u3001E2\u304c12.01 pg\/mL\u304b\u308913.22 pg\/mL\u306b\u4e0a\u6607\u3057\u3001DHT\u306f346.86 pg\/mL\u304b\u3089267.43 pg\/mL\u306b\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5909\u5316\u306f\u3044\u305a\u308c\u3082\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304b\u3089E2\u3078\u306e\u5909\u63db\u7387\u3092\u3082\u3068\u306b\u8a08\u7b97\u3055\u308c\u305fCYP19A1\u306e\u6d3b\u6027\u3082\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u6295\u4e0e\u7fa4\u3067\u660e\u3089\u304b\u306b\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u306f\u3001\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u8abf\u7bc0\u3084\u9175\u7d20\u69cb\u9020\u306e\u5909\u5316\u3001\u3042\u308b\u3044\u306f\u907a\u4f1d\u5b50\u5909\u7570\u306a\u3069\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u904e\u53bb\u306e\u7814\u7a76\u3067\u3082\u3001\u5c40\u6240\u7684\u306a\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u5408\u6210\u304c\u767a\u6bdb\u306b\u6709\u76ca\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u514d\u75ab\u86cd\u5149\u67d3\u8272\u3067\u767a\u73fe\u5909\u5316\u3092\u78ba\u8a8d<\/h3>\n\n\n\n<p>\u514d\u75ab\u86cd\u5149\u67d3\u8272\u306e\u7d50\u679c\u3082\u3001AR\u3068CYP17A1\u306e\u767a\u73fe\u304c<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u51e6\u7f6e\u7fa4\u3067\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001CYP19A1\u306e\u767a\u73fe\u306f\u5897\u52a0\u50be\u5411\u3092\u793a\u3057\u305f\u3082\u306e\u306e\u3001\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u306e\u30c7\u30fc\u30bf\u3068\u4e00\u81f4\u3057\u3066\u304a\u308a\u3001\u9175\u7d20\u306e\u6d3b\u6027\u304c\u767a\u73fe\u91cf\u3068\u306f\u72ec\u7acb\u3057\u3066\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u88cf\u4ed8\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/AGA.jpg\" alt=\"\u7121\u6599\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067AGA\u306e\u9032\u884c\u5ea6\u3092\u30c1\u30a7\u30c3\u30af\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306b\u3088\u3063\u3066\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u304c\u5358\u306a\u308b\u8840\u6d41\u4fc3\u9032\u85ac\u3084\u6210\u9577\u56e0\u5b50\u6d3b\u6027\u5316\u5264\u3068\u3057\u3066\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u30db\u30eb\u30e2\u30f3\u74b0\u5883\u305d\u306e\u3082\u306e\u3092\u8abf\u7bc0\u3059\u308b\u85ac\u5264<\/strong>\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u5177\u4f53\u7684\u306b\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08AR\uff09\u306e\u767a\u73fe\u3092\u6291\u3048\u308b\u3053\u3068\u3067DHT\u3078\u306e\u611f\u53d7\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u3001<\/li>\n\n\n\n<li>CYP17A1\u306e\u767a\u73fe\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u5c40\u6240\u7684\u306aDHT\u306e\u7523\u751f\u3092\u6e1b\u5c11\u3055\u305b\u3001<\/li>\n\n\n\n<li>CYP19A1\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067E2\u306e\u7523\u751f\u3092\u4fc3\u9032\u3057\u3001<\/li>\n<\/ul>\n\n\n\n<p>\u7d50\u679c\u7684\u306b\u3001\u6bdb\u5305\u5468\u56f2\u306eDHT\/E2\u6bd4\u3092\u6539\u5584\u3057\u3001\u9aea\u306e\u6210\u9577\u306b\u9069\u3057\u305f\u30db\u30eb\u30e2\u30f3\u74b0\u5883\u3092\u4f5c\u308a\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u65b0\u305f\u306a\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u767a\u898b\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/aga-treatment-options\/\">\u30df\u30ce\u30ad\u30b7\u30b8\u30eb<\/a>\u306b\u95a2\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u308b\u3068\u3068\u3082\u306b\u3001\u4eca\u5f8c\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/aga\/\">AGA<\/a>\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u5411\u3051\u305f\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u793a\u3059\u91cd\u8981\u306a\u77e5\u898b\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/AGA.jpg\" alt=\"\u7121\u6599\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067AGA\u306e\u9032\u884c\u5ea6\u3092\u30c1\u30a7\u30c3\u30af\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/32036577_s.jpg\" alt=\"\u9aea\" class=\"wp-image-7845\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32036577_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32036577_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32036577_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Shen, Y., Zhu, Y., Zhang, L., Sun, J., Xie, B., Zhang, H., &amp; Song, X. (2023). New&#8230;<\/p>\n","protected":false},"author":6,"featured_media":7823,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3,37],"tags":[242,249,247,215,248,245,121,252,250,166,126,251,241,246,244,243,21,240,185],"class_list":{"0":"post-7834","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-aga","8":"category-therapeutic_drugs","9":"tag-ar","10":"tag-cyp17a1","11":"tag-cyp19a1","12":"tag-dht","13":"tag-elisa","14":"tag-network-pharmacology","15":"tag-121","16":"tag-252","17":"tag-250","18":"tag-166","19":"tag-126","20":"tag-251","21":"tag-241","22":"tag-pcr","23":"tag-244","24":"tag-243","25":"tag-male_pattern_baldness","26":"tag-240","27":"tag-185","28":"article"},"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/posts\/7834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/comments?post=7834"}],"version-history":[{"count":5,"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/posts\/7834\/revisions"}],"predecessor-version":[{"id":7854,"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/posts\/7834\/revisions\/7854"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/media\/7823"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/media?parent=7834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/categories?post=7834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-json\/wp\/v2\/tags?post=7834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}