{"id":7897,"date":"2025-03-26T17:19:03","date_gmt":"2025-03-26T08:19:03","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/aga\/?p=7897"},"modified":"2025-03-26T17:19:03","modified_gmt":"2025-03-26T08:19:03","slug":"reversegray","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/aga\/reversegray\/","title":{"rendered":"\u767d\u9aea\u3063\u3066\u30b9\u30c8\u30ec\u30b9\u306e\u305b\u3044\u304b\u3082\uff1f\u9ed2\u9aea\u306b\u623b\u308b\u30d2\u30df\u30c4\u3001\u79d1\u5b66\u304c\u89e3\u660e\uff01"},"content":{"rendered":"\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\"><a href=\"https:\/\/doi.org\/10.7554\/eLife.67437\"><sup>Rosenberg, A. M., Rausser, S., Ren, J., Mosharov, E. V., Sturm, G., Ogden, R. T., Patel, P., Kumar Soni, R., Lacefield, C., Tobin, D. J., Paus, R., &amp; Picard, M. (2021). Quantitative mapping of human hair greying and reversal in relation to life stress. <em>eLife<\/em>, <em>10<\/em>, e67437. https:\/\/doi.org\/10.7554\/eLife.67437<\/sup><\/a><\/p>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u767d\u9aea, \u767d\u9aea\u306e\u539f\u56e0, \u767d\u9aea\u306e\u6539\u5584, \u30b9\u30c8\u30ec\u30b9\u3068\u767d\u9aea, \u767d\u9aea\u623b\u308b, \u9aea\u306e\u8272, \u9ed2\u9aea\u306b\u623b\u308b, \u30d8\u30a2\u30b1\u30a2, \u30e1\u30e9\u30cb\u30f3, \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2, \u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9, \u30bf\u30f3\u30d1\u30af\u8cea, \u9aea\u306e\u6210\u9577, \u9ad8\u6821\u751f, \u7f8e\u5bb9\u3068\u5065\u5eb7, \u5fc3\u3068\u9aea\u306e\u95a2\u4fc2, \u767d\u9aea\u3068\u52a0\u9f62, \u8001\u5316, \u518d\u8272\u7d20\u5316, \u30b9\u30c8\u30ec\u30b9\u30b1\u30a2, \u601d\u6625\u671f\u306e\u767d\u9aea<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u306f\u3058\u3081\u306b\uff1a\u767d\u9aea\u306e\u4ed5\u7d44\u307f\u3068\u30b9\u30c8\u30ec\u30b9\u3068\u306e\u95a2\u9023\u6027\u306b\u95a2\u3059\u308b\u7814\u7a76\u306e\u80cc\u666f<\/h2>\n\n\n\n<p>\u767d\u9aea\uff08hair greying\uff09\u306f\u3001\u52a0\u9f62\u306b\u4f34\u3063\u3066\u751f\u3058\u308b\u6700\u3082\u9855\u8457\u306a\u5916\u898b\u4e0a\u306e\u5909\u5316\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u4e00\u822c\u306b\u306f\u4e0d\u53ef\u9006\u7684\uff08irreversible\uff09\u306a\u73fe\u8c61\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u767d\u9aea\u306f\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u3068\u6df1\u304f\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u72b6\u6cc1\u306b\u3088\u3063\u3066\u306f\u518d\u3073\u8272\u7d20\u304c\u623b\u308b\u300c\u518d\u8272\u7d20\u5316\uff08repigmentation\uff09\u300d\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u4eba\u9593\u306e\u9aea\u306e\u6bdb1\u672c1\u672c\u306b\u6cbf\u3063\u3066\u6642\u9593\u7684\u306b\u5909\u5316\u3059\u308b\u8272\u7d20\u306e\u72b6\u614b\u3092\u8a73\u7d30\u306b\u8ffd\u8de1\u30fb\u5b9a\u91cf\u5316\u3059\u308b\u624b\u6cd5\u3092\u958b\u767a\u3057\u3001\u767d\u9aea\u5316\u3068\u305d\u306e\u81ea\u7136\u306a\u56de\u5fa9\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u9aea\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u7d44\u6210\uff08\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\uff1aproteome\uff09\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185\u4ee3\u8b1d\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff08mitochondria\uff09\u6a5f\u80fd\u3068\u306e\u95a2\u9023\u6027\u3082\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/29954288_s.jpg\" alt=\"\u4f53\u8abf\u4e0d\u5168\" class=\"wp-image-7708\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29954288_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29954288_s-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29954288_s-485x273.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u9aea\u306b\u8a18\u9332\u3055\u308c\u305f\u904e\u53bb\u306e\u30b9\u30c8\u30ec\u30b9\uff1a\u8272\u7d20\u5909\u5316\u30d1\u30bf\u30fc\u30f3\u306e\u53ef\u8996\u5316<\/h2>\n\n\n\n<p>\u9aea\u306e\u6bdb\uff08hair shaft\uff09\u306f\u3001\u6210\u9577\u3059\u308b\u904e\u7a0b\u3067\u4f53\u5185\u306e\u30db\u30eb\u30e2\u30f3\u3001\u4ee3\u8b1d\u3001\u305d\u3057\u3066\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u306e\u5185\u7684\u30fb\u5916\u7684\u8981\u56e0\u306e\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u5f71\u97ff\u306f\u3001\u9aea\u306e\u69cb\u9020\u306b\u6642\u7cfb\u5217\u7684\u306a\u60c5\u5831\u3068\u3057\u3066\u8a18\u9332\u3055\u308c\u3066\u304a\u308a\u3001\u307e\u308b\u3067\u6728\u306e\u5e74\u8f2a\u306e\u3088\u3046\u306b\u904e\u53bb\u306e\u751f\u7269\u5b66\u7684\u72b6\u614b\u3092\u300c\u8aad\u307f\u53d6\u308b\u300d\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u9aea\u306b\u304a\u3051\u308b\u8272\u7d20\u6c88\u7740\u30d1\u30bf\u30fc\u30f3\uff08Hair Pigmentation Patterns, HPPs\uff09\u3092\u9ad8\u89e3\u50cf\u5ea6\u3067\u30b9\u30ad\u30e3\u30f3\u3057\u3001\u6bdb\u5148\u304b\u3089\u6839\u5143\u307e\u3067\u306e\u8272\u306e\u5909\u5316\u3092\u6642\u9593\u8ef8\u3068\u3057\u3066\u518d\u69cb\u6210\u3057\u307e\u3057\u305f\u3002\u9aea\u306e\u6210\u9577\u901f\u5ea6\u3092\u304a\u304a\u3088\u305d\u67081\u30bb\u30f3\u30c1\u3068\u4eee\u5b9a\u3057\u3001\u8272\u306e\u5909\u5316\u3092\u6708\u5358\u4f4d\u3067\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u9aea\u306e\u8272\u7d20\u5909\u5316\u3092\u5b9a\u91cf\u7684\u306b\u53ef\u8996\u5316\u3059\u308b\u624b\u6cd5\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/31621181_s.jpg\" alt=\"\" class=\"wp-image-7855\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/31621181_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/31621181_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/31621181_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u81ea\u7136\u306a\u767d\u9aea\u306e\u518d\u8272\u7d20\u5316\uff1a\u8907\u6570\u306e\u5b9f\u4f8b\u304b\u3089\u306e\u767a\u898b<\/h2>\n\n\n\n<p>\u89e3\u6790\u306e\u7d50\u679c\u3001\u767d\u9aea\u5316\u3057\u305f\u9aea\u304c\u518d\u3073\u9ed2\u304f\u623b\u308b\u300c\u518d\u8272\u7d20\u5316\u300d\u306e\u73fe\u8c61\u304c\u3001\u5065\u5eb7\u306a\u6210\u4eba\u306b\u304a\u3044\u3066\u591a\u6570\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u767d\u9aea\u304c\u81ea\u7136\u306b\u9ed2\u9aea\u3078\u623b\u308b\u4e8b\u4f8b\u306f\u6975\u3081\u3066\u7a00\u3067\u3001\u500b\u5225\u306e\u75c7\u4f8b\u5831\u544a\u306b\u3068\u3069\u307e\u3063\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u672c\u7814\u7a76\u3067\u306f\u6027\u5225\u3001\u4eba\u7a2e\u3001\u5e74\u9f62\u3001\u3055\u3089\u306b\u306f\u4f53\u306e\u90e8\u4f4d\u3092\u554f\u308f\u305a\u3001\u8907\u6570\u306e\u9aea\u306e\u6bdb\u3067\u3053\u306e\u73fe\u8c61\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" class=\"alignnone\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/Basic-knowledge.png\" alt=\"\u300c\u3053\u308c\u3063\u3066AGA\u304b\u3082\uff1f\u300d\u3068\u601d\u3063\u305f\u3089\u4eca\u3059\u3050\u30c1\u30a7\u30c3\u30af\uff06\u76f8\u8ac7\" width=\"980\" height=\"296\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<p>\u767d\u9aea\u304b\u3089\u9ed2\u9aea\u3078\u306e\u5909\u5316\u306e\u901f\u5ea6\u306f\u30011\u65e5\u3042\u305f\u308a0.1\u301c42.5\u306e\u5149\u5b66\u6fc3\u5ea6\u5358\u4f4d\uff08Optical Density Units\uff1a0\u301c255\u30b9\u30b1\u30fc\u30eb\uff09\u3067\u3042\u308a\u3001\u767d\u9aea\u5316\u306e\u901f\u5ea6\uff080.3\u301c23.5\u5358\u4f4d\uff0f\u65e5\uff09\u3068\u540c\u7b49\u3001\u3082\u3057\u304f\u306f\u305d\u308c\u3092\u4e0a\u56de\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8272\u7d20\u306e\u5909\u5316\u304c\u6bd4\u8f03\u7684\u77ed\u671f\u9593\u3067\u8d77\u3053\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/32198837_s.jpg\" alt=\"\u679d\u6bdb\u3042\u308b\u304b\u306a\" class=\"wp-image-7871\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32198837_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32198837_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32198837_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u96fb\u5b50\u9855\u5fae\u93e1\u306b\u3088\u308b\u30e1\u30e9\u30cb\u30f3\u69cb\u9020\u306e\u6bd4\u8f03<\/h2>\n\n\n\n<p>\u96fb\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305f\u89b3\u5bdf\u306b\u3088\u308a\u3001\u9ed2\u9aea\u306b\u306f\u30e1\u30e9\u30cb\u30f3\u9846\u7c92\uff08melanin granules\uff09\u304c\u8c4a\u5bcc\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u4e00\u65b9\u3067\u3001\u767d\u9aea\u306b\u306f\u3053\u308c\u3089\u306e\u30e1\u30e9\u30cb\u30f3\u9846\u7c92\u304c\u307b\u3068\u3093\u3069\u5b58\u5728\u3057\u306a\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u767d\u9aea\u4e2d\u306b\u6b8b\u5b58\u3057\u3066\u3044\u308b\u5c11\u91cf\u306e\u30e1\u30e9\u30cb\u30f3\u9846\u7c92\u306f\u3001\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u304f\u3001\u5bc6\u5ea6\u3082\u4f4e\u304f\u3001\u3057\u3070\u3057\u3070\u7a7a\u80de\uff08vacuoles\uff09\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5909\u5316\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u7d30\u80de\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff08oxidative stress\uff09\u306b\u3055\u3089\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/31968307_s.jpg\" alt=\"\u9855\u5fae\u93e1\" class=\"wp-image-7874\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/31968307_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/31968307_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/31968307_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u767d\u9aea\u3067\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u5909\u5316\u3068\u305d\u306e\u751f\u7269\u5b66\u7684\u610f\u7fa9<\/h2>\n\n\n\n<p>\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\uff08proteomics\uff09\u89e3\u6790\u306b\u3088\u308a\u3001\u767d\u9aea\u3067\u306f\u9ed2\u9aea\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u95a2\u4fc2\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u4ee3\u8b1d\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\uff08energy metabolism\uff09\u3001\u8102\u80aa\u9178\u5408\u6210\uff08fatty acid synthesis\uff09\u3001\u6297\u9178\u5316\u9632\u5fa1\uff08antioxidant defense\uff09\u306b\u95a2\u9023\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4ee3\u8868\u7684\u306a\u5897\u52a0\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u3001\u8102\u80aa\u9178\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u30ab\u30eb\u30cb\u30c1\u30f3\u30d1\u30eb\u30df\u30c8\u30a4\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc1A\uff08Carnitine Palmitoyltransferase 1A\uff1aCPT1A\uff09\u3001\u8102\u8cea\u5206\u89e3\u306b\u95a2\u4e0e\u3059\u308b\u30a2\u30b7\u30ebCoA\u30c1\u30aa\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc7\uff08Acyl-CoA Thioesterase 7\uff1aACOT7\uff09\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08reactive oxygen species, ROS\uff09\u306e\u7121\u5bb3\u5316\u306b\u50cd\u304f\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30c7\u30a3\u30b9\u30e0\u30bf\u30fc\u30bc1\uff08Superoxide Dismutase 1\uff1aSOD1\uff09\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\uff08melanosome\uff1a\u30e1\u30e9\u30cb\u30f3\u3092\u84c4\u7a4d\u3059\u308b\u7d30\u80de\u5c0f\u5668\u5b98\uff09\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u30ea\u30bd\u30bd\u30fc\u30e0\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u90e8\u3001\u305f\u3068\u3048\u3070LAMP1\uff08Lysosome-Associated Membrane Protein 1\uff09\u306f\u3001\u767d\u9aea\u3067\u306f\u767a\u73fe\u304c\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306e\u5f62\u6210\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/29687138_s.jpg\" alt=\"\" class=\"wp-image-7812\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29687138_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29687138_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/29687138_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u9aea\u306e\u8272\u7d20\u5909\u5316\u3068\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u306e\u6642\u7cfb\u5217\u7684\u5bfe\u5fdc<\/h2>\n\n\n\n<p>\u88ab\u9a13\u8005\u306e\u4e00\u90e8\u306b\u3064\u3044\u3066\u306f\u3001\u904e\u53bb1\u5e74\u9593\u306e\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u30ec\u30d9\u30eb\u3092\u81ea\u5df1\u7533\u544a\u3067\u8a18\u9332\u3057\u3001\u305d\u306e\u30c7\u30fc\u30bf\u3092\u9aea\u306eHPP\uff08Hair Pigmentation Patterns\uff09\u3068\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u5f37\u3044\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u3066\u3044\u305f\u6642\u671f\u306b\u9aea\u304c\u767d\u304f\u306a\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u304c\u7de9\u548c\u3055\u308c\u305f\u6642\u671f\u306b\u9aea\u304c\u518d\u3073\u9ed2\u304f\u306a\u308b\u3068\u3044\u3046\u3001\u660e\u78ba\u306a\u6642\u9593\u7684\u5bfe\u5fdc\u95a2\u4fc2\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u304c\u9aea\u306e\u8272\u7d20\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u76f4\u63a5\u7684\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u3092\u793a\u3059\u91cd\u8981\u306a\u8a3c\u62e0\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/28599892_s.jpg\" alt=\"\" class=\"wp-image-7660\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28599892_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28599892_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/28599892_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u6570\u7406\u30e2\u30c7\u30eb\u306b\u3088\u308b\u767d\u9aea\u5316\u3068\u518d\u8272\u7d20\u5316\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3<\/h2>\n\n\n\n<p>\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u9aea\u306e\u8001\u5316\u3068\u767d\u9aea\u5316\u306e\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u3092\u518d\u73fe\u3059\u308b\u305f\u3081\u306b\u3001\u4ee5\u4e0b\u306e\u8981\u7d20\u3092\u542b\u3080\u6570\u7406\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>1\u3064\u76ee\u306f\u3001\u300c\u52a0\u9f62\u8981\u56e0\uff08aging factor\uff09\u300d\u306e\u6642\u9593\u7684\u84c4\u7a4d\u3067\u3059\u3002\u9aea\u306e\u6bdb\u306f\u6642\u9593\u3068\u3068\u3082\u306b\u8001\u5316\u56e0\u5b50\u3092\u84c4\u7a4d\u3057\u3001\u4e00\u5b9a\u306e\u95be\u5024\uff08threshold\uff09\u3092\u8d85\u3048\u308b\u3068\u767d\u9aea\u5316\u304c\u751f\u3058\u307e\u3059\u30022\u3064\u76ee\u306f\u3001\u3053\u306e\u95be\u5024\u306b\u9054\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u6570\u7406\u7684\u8868\u73fe\u3067\u3059\u30023\u3064\u76ee\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u8981\u56e0\uff08stress factor\uff09\u304c\u4e00\u6642\u7684\u306b\u52a0\u9f62\u8981\u56e0\u3092\u52a0\u901f\u3055\u305b\u3001\u6025\u6fc0\u306a\u767d\u9aea\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u3068\u3044\u3046\u4eee\u8aac\u306b\u57fa\u3065\u304f\u8981\u7d20\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u30e2\u30c7\u30eb\u306b\u3088\u308a\u3001\u5b9f\u969b\u306e\u4eba\u9593\u306b\u898b\u3089\u308c\u308b\u3088\u3046\u306a\u52a0\u9f62\u306b\u4f34\u3046\u767d\u9aea\u5316\u306e\u9032\u884c\u3084\u3001\u7279\u5b9a\u306e\u9aea\u306e\u6bdb\u3060\u3051\u304c\u4e00\u6642\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u767d\u9aea\u5316\u3057\u3001\u305d\u306e\u5f8c\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b\u306b\u3088\u308a\u9ed2\u304f\u623b\u308b\u3068\u3044\u3063\u305f\u73fe\u8c61\u3092\u30b7\u30df\u30e5\u30ec\u30fc\u30c8\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/32036577_s.jpg\" alt=\"\u9aea\" class=\"wp-image-7845\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32036577_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32036577_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32036577_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u767d\u9aea\u306f\u672c\u5f53\u306b\u4e0d\u53ef\u9006\u304b\uff1f\u8001\u5316\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u8996\u70b9<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001\u4eba\u9593\u306e\u767d\u9aea\u5316\u73fe\u8c61\u304c\u5b8c\u5168\u306b\u4e0d\u53ef\u9006\u7684\u3067\u3042\u308b\u3068\u306f\u9650\u3089\u305a\u3001\u7279\u5b9a\u306e\u6761\u4ef6\u4e0b\u3067\u306f\u518d\u3073\u8272\u7d20\u3092\u53d6\u308a\u623b\u3059\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u8001\u5316\u5168\u4f53\u304c\u4e00\u65b9\u5411\u306b\u9032\u884c\u3059\u308b\u5358\u7d14\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u306a\u304f\u3001\u5c11\u306a\u304f\u3068\u3082\u4e00\u90e8\u306f\u53ef\u9006\u7684\uff08reversible\uff09\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u9aea\u306e\u8272\u7d20\u5909\u5316\u3092\u6307\u6a19\u3068\u3057\u3066\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u304c\u751f\u4f53\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u6642\u9593\u7684\u306b\u8a55\u4fa1\u3059\u308b\u65b0\u305f\u306a\u65b9\u6cd5\u3092\u63d0\u4f9b\u3067\u304d\u307e\u3059\u3002\u9aea\u306e\u6bdb\u306f\u3001\u5916\u90e8\u304b\u3089\u975e\u4fb5\u8972\u7684\u306b\u53d6\u5f97\u53ef\u80fd\u3067\u3042\u308a\u3001\u500b\u4eba\u306e\u751f\u7406\u7684\u30fb\u5fc3\u7406\u7684\u5c65\u6b74\u3092\u53cd\u6620\u3059\u308b\u8cb4\u91cd\u306a\u30d0\u30a4\u30aa\u30a2\u30fc\u30ab\u30a4\u30d6\uff08bioarchive\uff09\u3068\u3057\u3066\u6d3b\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u9aea\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u7d44\u6210\u306e\u5909\u5316\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u6bdb\u5305\uff08hair follicle\uff09\u5185\u90e8\u306e\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\uff08melanocyte\uff1a\u30e1\u30e9\u30cb\u30f3\u3092\u7523\u751f\u3059\u308b\u7d30\u80de\uff09\u306e\u4ee3\u8b1d\u72b6\u614b\u3092\u9593\u63a5\u7684\u306b\u63a8\u5b9a\u3059\u308b\u624b\u6cd5\u3068\u3057\u3066\u3082\u6709\u671b\u3067\u3059\u3002\u4eca\u5f8c\u306f\u3001\u3053\u306e\u624b\u6cd5\u3092\u5fdc\u7528\u3057\u3001\u74b0\u5883\u7684\u30fb\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u8981\u56e0\u304c\u8001\u5316\u304a\u3088\u3073\u9aea\u306e\u8272\u7d20\u52d5\u614b\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u3088\u308a\u8a73\u7d30\u306b\u89e3\u6790\u3059\u308b\u7814\u7a76\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register?department=aga\"><br \/>\n<img decoding=\"async\" class=\"alignnone\" src=\"\/aga\/wp-content\/uploads\/2025\/04\/Basic-knowledge.png\" alt=\"\u300c\u3053\u308c\u3063\u3066AGA\u304b\u3082\uff1f\u300d\u3068\u601d\u3063\u305f\u3089\u4eca\u3059\u3050\u30c1\u30a7\u30c3\u30af\uff06\u76f8\u8ac7\" width=\"980\" height=\"296\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/aga\/wp-content\/uploads\/2025\/03\/32029542_s.jpg\" alt=\"\u307d\u3061\u3063\u3068\" class=\"wp-image-7540\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32029542_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32029542_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/aga\/wp-content\/uploads\/2025\/03\/32029542_s-485x324.jpg 485w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Rosenberg, A. M., Rausser, S., Ren, J., Mosharov, E. V., Sturm, G., Ogden, R. 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