{"id":4503,"date":"2025-03-28T12:53:22","date_gmt":"2025-03-28T03:53:22","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/?p=4503"},"modified":"2025-04-24T17:40:22","modified_gmt":"2025-04-24T08:40:22","slug":"jpfaceage","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/derma\/jpfaceage\/","title":{"rendered":"\u4e16\u754c\u306e\u5973\u306e\u5b50\u306e\u201c\u672a\u6765\u306e\u808c\u201d\u306f\u3069\u3053\u304c\u9055\u3046\uff1f\u65e5\u672c\u30fb\u30a2\u30e1\u30ea\u30ab\u30fb\u30a2\u30b8\u30a2\u5404\u5730\u3067\u6bd4\u3079\u3066\u307f\u305f\u300c\u9854\u306e\u30b7\u30ef\u3068\u305f\u308b\u307f\u300d\u306e\u8a71"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u4eba\u7a2e\u3084\u5730\u57df\u306b\u3088\u308b\u9854\u306e\u8001\u5316\u306e\u9055\u3044<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u767d\u4eba\u5973\u6027\u3068\u65e5\u672c\u4eba\u5973\u6027\u306b\u304a\u3051\u308b\u30b7\u30ef\u3068\u305f\u308b\u307f\u306e\u6bd4\u8f03<\/h3>\n\n\n\n<p>2004\u5e74\u306bTsukahara\u3089\u304c\u884c\u3063\u305f\u7814\u7a76\u3067\u306f\u3001\u30a2\u30e1\u30ea\u30ab\u30fb\u30aa\u30cf\u30a4\u30aa\u5dde\u30b7\u30f3\u30b7\u30ca\u30c6\u30a3\u306b\u4f4f\u3080\u5065\u5eb7\u306a\u767d\u4eba\u5973\u602785\u540d\u3068\u3001\u65e5\u672c\u30fb\u6771\u4eac\u306b\u4f4f\u3080\u5065\u5eb7\u306a\u65e5\u672c\u4eba\u5973\u602770\u540d\uff08\u3044\u305a\u308c\u308220\u301c69\u6b73\uff09\u3092\u5bfe\u8c61\u306b\u3001\u9854\u306e\u30b7\u30ef\u304a\u3088\u3073\u305f\u308b\u307f\u306e\u5e74\u9f62\u5909\u5316\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u8a55\u4fa1\u306f\u3001\u6b63\u9762\u304a\u3088\u3073\u659c\u308145\u5ea6\u304b\u3089\u64ae\u5f71\u3057\u305f\u6a19\u6e96\u5316\u3055\u308c\u305f\u9854\u5199\u771f\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u3001\u5168\u54e1\u306e\u30b7\u30ef\u3068\u305f\u308b\u307f\u3092\u540c\u4e00\u306e\u719f\u7df4\u3057\u305f\u8a55\u4fa1\u8005\u304c\u63a1\u70b9\u3059\u308b\u3053\u3068\u3067\u3001\u4e3b\u89b3\u306e\u5f71\u97ff\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u9854\u306e\u30b7\u30ef\u306f\u3001\u984d\uff08forehead\uff09\u3001\u7709\u9593\uff08glabella\uff09\u3001\u4e0a\u307e\u3076\u305f\uff08upper eyelid\uff09\u3001\u76ee\u5c3b\uff08outer eye corner, \u901a\u79f0crow\u2019s feet\uff09\u3001\u4e0b\u307e\u3076\u305f\uff08lower eyelid\uff09\u3001\u982c\uff08cheek\uff09\u3001\u9f3b\u5507\u6e9d\uff08nasolabial groove\uff09\u3001\u53e3\u89d2\uff08corner of the mouth\uff09\u306e8\u90e8\u4f4d\u306b\u308f\u305f\u3063\u3066\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u90e8\u4f4d\u306f\u3001\u9854\u306e\u8868\u60c5\u306b\u95a2\u308f\u308b\u7b4b\u8089\u3084\u76ae\u819a\u306e\u69cb\u9020\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u90e8\u4f4d\u3054\u3068\u306e\u52a0\u9f62\u5909\u5316\u306e\u50be\u5411\u3092\u8a73\u7d30\u306b\u628a\u63e1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32198837_s.jpg\" alt=\"\" class=\"wp-image-4451\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32198837_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32198837_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7d50\u679c\u3068\u3057\u3066\u3001\u4e21\u30b0\u30eb\u30fc\u30d7\u3068\u3082\u3059\u3079\u3066\u306e\u90e8\u4f4d\u3067\u30b7\u30ef\u306e\u30b9\u30b3\u30a2\u306f\u52a0\u9f62\u306b\u4f34\u3063\u3066\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u300120\u301c29\u6b73\u306e\u82e5\u5e74\u5c64\u3067\u306f\u767d\u4eba\u5973\u6027\u306e\u65b9\u304c\u6709\u610f\u306b\u9ad8\u3044\u30b7\u30ef\u30b9\u30b3\u30a2\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u767d\u4eba\u5973\u6027\u3067\u306f\u6bd4\u8f03\u7684\u82e5\u3044\u6bb5\u968e\u304b\u3089\u30b7\u30ef\u306e\u5f62\u6210\u304c\u59cb\u307e\u308b\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<p>\u307e\u305f\u3001\u5e74\u9f62\u304c\u9032\u3080\u306b\u3064\u308c\u3066\u984d\u3084\u7709\u9593\u3001\u4e0a\u307e\u3076\u305f\u3001\u76ee\u5c3b\u306a\u3069\u306e\u201c\u9854\u306e\u4e0a\u90e8\u201d\u306b\u95a2\u3057\u3066\u306f\u3001\u4e21\u30b0\u30eb\u30fc\u30d7\u306e\u30b7\u30ef\u30b9\u30b3\u30a2\u306f\u307b\u307c\u540c\u3058\u306b\u306a\u3063\u3066\u3044\u304d\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u201c\u9854\u306e\u4e0b\u90e8\u201d\u306b\u3042\u305f\u308b\u4e0b\u307e\u3076\u305f\u3001\u982c\u3001\u9f3b\u5507\u6e9d\u3001\u53e3\u89d2\u306e\u30b7\u30ef\u306b\u95a2\u3057\u3066\u306f\u3001\u5168\u3066\u306e\u5e74\u9f62\u5c64\u306b\u304a\u3044\u3066\u767d\u4eba\u5973\u6027\u306e\u65b9\u304c\u65e5\u672c\u4eba\u5973\u6027\u3088\u308a\u9855\u8457\u306b\u9ad8\u3044\u30b9\u30b3\u30a2\u3092\u793a\u3057\u3001\u305d\u306e\u5dee\u306f\u5e74\u9f62\u3068\u3068\u3082\u306b\u3055\u3089\u306b\u62e1\u5927\u3059\u308b\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32147407_s.jpg\" alt=\"\u76ae\u819a\" class=\"wp-image-4452\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32147407_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32147407_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u52a0\u3048\u3066\u3001\u982c\u9aa8\u4e0b\u90e8\uff08subzygomatic area\uff09\u306b\u304a\u3051\u308b\u76ae\u819a\u306e\u305f\u308b\u307f\u30b9\u30b3\u30a2\u3082\u5e74\u9f62\u3068\u3068\u3082\u306b\u4e0a\u6607\u3057\u3066\u304a\u308a\u3001\u7279\u306b40\u6b73\u4ee5\u4e0a\u306e\u5e74\u9f62\u5c64\u3067\u306f\u767d\u4eba\u5973\u6027\u306e\u30b9\u30b3\u30a2\u304c\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u767d\u4eba\u5973\u6027\u304c\u65e5\u672c\u4eba\u5973\u6027\u306b\u6bd4\u3079\u3066\u9854\u306e\u4e0b\u90e8\u306b\u304a\u3051\u308b\u76ae\u819a\u306e\u305f\u308b\u307f\u306b\u5bfe\u3057\u3066\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u305d\u306e\u5f71\u97ff\u3067\u30b7\u30ef\u3082\u3088\u308a\u9855\u8457\u306b\u73fe\u308c\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u76ae\u819a\u306e\u305f\u308b\u307f\u306f\u3001\u76ae\u819a\u306e\u5f3e\u529b\u6027\u306e\u4f4e\u4e0b\u3001\u771f\u76ae\uff08\u76ae\u819a\u306e\u4e2d\u5c64\uff09\u306b\u542b\u307e\u308c\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u3068\u3044\u3063\u305f\u69cb\u9020\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5909\u6027\u3001\u91cd\u529b\u306e\u5f71\u97ff\u306a\u3069\u304c\u8907\u96d1\u306b\u95a2\u4fc2\u3057\u3066\u751f\u3058\u308b\u73fe\u8c61\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u9854\u306e\u4e0b\u90e8\u306e\u30b7\u30ef\u304c\u76ee\u7acb\u3061\u3084\u3059\u3044\u3068\u3044\u3046\u306e\u306f\u3001\u5358\u306a\u308b\u8868\u76ae\u306e\u5909\u5316\u3060\u3051\u3067\u306a\u304f\u3001\u6df1\u5c64\u69cb\u9020\u306e\u5909\u5316\u3084\u9854\u5168\u4f53\u306e\u89e3\u5256\u5b66\u7684\u7279\u6027\u3082\u5f71\u97ff\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/4494105_s.jpg\" alt=\"\u306a\u3084\u307f\" class=\"wp-image-4490\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/4494105_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/4494105_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30a2\u30b8\u30a2\u5973\u6027\u306b\u304a\u3051\u308b\u9854\u306e\u8001\u5316\u306e\u90fd\u5e02\u9593\u6bd4\u8f03\uff1a\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u30bf\u30a4<\/h3>\n\n\n\n<p>Tsukahara\u3089\u306f2007\u5e74\u306b\u3001\u3055\u3089\u306b\u7814\u7a76\u306e\u5bfe\u8c61\u3092\u5e83\u3052\u3001\u6771\u4eac\uff08\u65e5\u672c\uff09\u3001\u4e0a\u6d77\uff08\u4e2d\u56fd\uff09\u3001\u30d0\u30f3\u30b3\u30af\uff08\u30bf\u30a4\uff09\u306b\u5c45\u4f4f\u3059\u308b\u30a2\u30b8\u30a2\u4eba\u5973\u6027277\u540d\u3092\u5bfe\u8c61\u306b\u3001\u9854\u306e\u30b7\u30ef\u3068\u982c\u306e\u305f\u308b\u307f\u306e\u52a0\u9f62\u5909\u5316\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u5bfe\u8c61\u5e74\u9f62\u306f10\u4ee3\u304b\u308960\u4ee3\u307e\u3067\u5e45\u5e83\u304f\u3001\u5e74\u9f62\u3054\u3068\u306b\u5e74\u4ee3\u5225\u306e\u50be\u5411\u3092\u8a73\u7d30\u306b\u628a\u63e1\u3059\u308b\u3053\u3068\u304c\u76ee\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u9854\u306e\u30b7\u30ef\u306f\u524d\u8ff0\u3068\u540c\u69d8\u306b8\u90e8\u4f4d\u3067\u8a55\u4fa1\u3055\u308c\u3001\u982c\u306e\u305f\u308b\u307f\u306f\u65e5\u672c\u4eba\u5973\u6027\u306e\u5199\u771f\u3092\u3082\u3068\u306b\u958b\u767a\u3055\u308c\u305f6\u6bb5\u968e\u30b9\u30b1\u30fc\u30eb\u3067\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u5168\u3066\u306e\u5199\u771f\u306f\u6b63\u9762\u304a\u3088\u3073\u659c\u4f4d\u304b\u3089\u6a19\u6e96\u5316\u3055\u308c\u305f\u6761\u4ef6\u4e0b\u3067\u64ae\u5f71\u3055\u308c\u30011\u540d\u306e\u8a55\u4fa1\u8005\u306b\u3088\u3063\u3066\u4e00\u8cab\u3057\u3066\u63a1\u70b9\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/2124815_s.jpg\" alt=\"\u30bf\u30a4\u4eba\u5973\u6027\" class=\"wp-image-4507\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/2124815_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/2124815_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7d50\u679c\u3068\u3057\u3066\u3001\u3059\u3079\u3066\u306e\u90fd\u5e02\u306e\u3059\u3079\u3066\u306e\u9854\u90e8\u4f4d\u306b\u304a\u3044\u3066\u3001\u5e74\u9f62\u3068\u3068\u3082\u306b\u30b7\u30ef\u306e\u30b9\u30b3\u30a2\u304c\u4e0a\u6607\u3059\u308b\u660e\u78ba\u306a\u76f8\u95a2\u304c\u898b\u3089\u308c\u307e\u3057\u305f\uff08\u76f8\u95a2\u4fc2\u6570r = 0.799\u301c0.931\u3001p &lt; 0.01\uff09\u3002\u7279\u306b\u3001\u30d0\u30f3\u30b3\u30af\u306e\u30bf\u30a4\u4eba\u5973\u6027\u304c\u6700\u3082\u6df1\u3044\u30b7\u30ef\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u6b21\u306b\u4e2d\u56fd\u4eba\u5973\u6027\u3001\u305d\u3057\u3066\u6700\u3082\u5c11\u306a\u304b\u3063\u305f\u306e\u304c\u65e5\u672c\u4eba\u5973\u6027\u3068\u3044\u3046\u9806\u5e8f\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u50be\u5411\u306f\u3001\u9854\u306e\u4e0b\u90e8\uff08\u982c\u3001\u9f3b\u5507\u6e9d\u3001\u53e3\u89d2\uff09\u3067\u7279\u306b\u9855\u8457\u3067\u3042\u308a\u3001\u30bf\u30a4\u4eba\u5973\u6027\u306f20\u4ee3\u304b\u308950\u4ee3\u306b\u304b\u3051\u3066\u660e\u78ba\u306b\u4ed6\u306e\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u6df1\u3044\u30b7\u30ef\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4e2d\u56fd\u4eba\u5973\u6027\u306f\u3001\u7709\u9593\u3084\u76ee\u5c3b\u306a\u3069\u306e\u201c\u76ee\u306e\u5468\u56f2\u201d\u306b\u304a\u3044\u3066\u3001\u65e5\u672c\u4eba\u5973\u6027\u3088\u308a\u3082\u30b7\u30ef\u306e\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<p>\u982c\u306e\u305f\u308b\u307f\u306b\u95a2\u3057\u3066\u306f\u30013\u90fd\u5e02\u3059\u3079\u3066\u3067\u5e74\u9f62\u306b\u5fdc\u3058\u3066\u30b9\u30b3\u30a2\u304c\u4e0a\u6607\u3057\u307e\u3057\u305f\u304c\u3001\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u5dee\u304c\u78ba\u8a8d\u3055\u308c\u305f\u306e\u306f\u3001\u65e5\u672c\u4eba\u3068\u30bf\u30a4\u4eba\u5973\u6027\u306e30\u4ee3\u304a\u3088\u307350\u4ee3\u306b\u9650\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u308c\u4ee5\u5916\u306e\u7d44\u307f\u5408\u308f\u305b\uff08\u65e5\u672c\u4ebavs\u4e2d\u56fd\u4eba\u3001\u4e2d\u56fd\u4ebavs\u30bf\u30a4\u4eba\uff09\u3067\u306f\u6709\u610f\u306a\u5dee\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/30420729_s.jpg\" alt=\"\u767d\u4eba\u5973\u6027\" class=\"wp-image-4508\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/30420729_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/30420729_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u74b0\u5883\u3084\u6587\u5316\u7684\u80cc\u666f\u304c\u4e0e\u3048\u308b\u5f71\u97ff<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6c17\u5019\u6761\u4ef6\u3068\u7d2b\u5916\u7dda\u66dd\u9732\u306e\u5f71\u97ff<\/h3>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u90fd\u5e02\u306e\u6c17\u5019\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3059\u308b\u3068\u3001\u6771\u4eac\u3068\u4e0a\u6d77\u306f\u7def\u5ea6\u304c\u8fd1\u304f\u3001\u5e73\u5747\u6c17\u6e29\u308215.9\u00b0C\u306816.1\u00b0C\u3067\u307b\u307c\u540c\u3058\u3067\u3059\u3002\u4e00\u65b9\u3001\u30d0\u30f3\u30b3\u30af\u306f\u8d64\u9053\u306b\u8fd1\u304f\u3001\u5e74\u9593\u5e73\u5747\u6c17\u6e29\u306f28.6\u00b0C\u3068\u304b\u306a\u308a\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u964d\u6c34\u91cf\u306f\u6771\u4eac\u306e1,467 mm\u306b\u5bfe\u3057\u3066\u3001\u30d0\u30f3\u30b3\u30af\u306f\u308f\u305a\u304b529 mm\u3068\u4e7e\u71e5\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u5e74\u9593\u3092\u901a\u3058\u3066\u7d2b\u5916\u7dda\uff08UV\uff09\u66dd\u9732\u91cf\u304c\u591a\u3044\u3068\u63a8\u5bdf\u3055\u308c\u307e\u3059\u3002\u7d2b\u5916\u7dda\u306f\u76ae\u819a\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u5206\u89e3\u3057\u3001\u5149\u8001\u5316\uff08photoaging\uff09\u3092\u9032\u884c\u3055\u305b\u308b\u4e3b\u8981\u306a\u5916\u56e0\u6027\u56e0\u5b50\u3067\u3042\u308b\u305f\u3081\u3001\u6c17\u5019\u304c\u8001\u5316\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306f\u7121\u8996\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/29687138_s.jpg\" alt=\"\" class=\"wp-image-4449\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/29687138_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/29687138_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u808c\u306e\u660e\u308b\u3055\u3068\u30b7\u30ef\u306e\u898b\u3048\u65b9<\/h3>\n\n\n\n<p>\u808c\u306e\u660e\u308b\u3055\u3092\u6570\u5024\u5316\u3059\u308b\u5c3a\u5ea6\u3067\u3042\u308bL*\uff08L-star\uff09\u5024\u306b\u3088\u308b\u3068\u3001\u65e5\u672c\u4eba\u3084\u4e2d\u56fd\u4eba\u306f\u6bd4\u8f03\u7684\u660e\u308b\u3044\u808c\u8272\u3092\u6301\u3061\u3001\u30bf\u30a4\u4eba\u5973\u6027\u306f\u3088\u308a\u6697\u3044\u808c\u8272\u3092\u6301\u3064\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u808c\u304c\u6697\u3044\u3068\u3001\u5149\u306e\u53cd\u5c04\u7387\u304c\u4f4e\u304f\u306a\u308b\u305f\u3081\u3001\u30b7\u30ef\u3084\u305f\u308b\u307f\u3068\u3044\u3063\u305f\u51f9\u51f8\u304c\u3088\u308a\u76ee\u7acb\u3061\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u3082\u3001\u30bf\u30a4\u4eba\u5973\u6027\u306b\u304a\u3044\u3066\u30b7\u30ef\u304c\u6df1\u304f\u898b\u3048\u308b\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/31563936_s.jpg\" alt=\"\u3057\u308f\" class=\"wp-image-4509\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31563936_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31563936_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3068\u8868\u60c5\u306e\u4f7f\u3044\u65b9\u306e\u9055\u3044<\/h3>\n\n\n\n<p>\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u89b3\u70b9\u304b\u3089\u306f\u3001\u65e5\u672c\u4eba\u5973\u6027\u306e\u55ab\u7159\u7387\u304c10\u301c19%\u3068\u6bd4\u8f03\u7684\u9ad8\u3044\u4e00\u65b9\u3067\u3001\u30b7\u30ef\u306e\u30b9\u30b3\u30a2\u306f\u6700\u3082\u4f4e\u3044\u3068\u3044\u3046\u7d50\u679c\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u55ab\u7159\u4ee5\u5916\u306e\u8981\u56e0\u3001\u7279\u306b\u65e5\u5e38\u7684\u306a\u7d2b\u5916\u7dda\u5bfe\u7b56\uff08\u305f\u3068\u3048\u3070\u65e5\u713c\u3051\u6b62\u3081\u306e\u4f7f\u7528\uff09\u3084\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u7fd2\u6163\u304c\u3001\u8001\u5316\u306b\u5f37\u3044\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001\u65e5\u672c\u4eba\u5973\u6027\u306f\u65e5\u713c\u3051\u6b62\u3081\u3084\u30d5\u30a1\u30f3\u30c7\u30fc\u30b7\u30e7\u30f3\u306e\u4f7f\u7528\u983b\u5ea6\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u304a\u308a\u3001\u7d2b\u5916\u7dda\u304b\u3089\u808c\u3092\u4fdd\u8b77\u3059\u308b\u884c\u52d5\u304c\u5e83\u304f\u6d78\u900f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u6587\u5316\u7684\u306a\u8868\u60c5\u306e\u9055\u3044\u3001\u7279\u306b\u65e5\u5e38\u7684\u306a\u7b11\u9854\u3084\u767a\u8a71\u6642\u306e\u53e3\u306e\u52d5\u304d\u304c\u76ae\u819a\u306e\u7279\u5b9a\u90e8\u4f4d\u306b\u4e0e\u3048\u308b\u6a5f\u68b0\u7684\u30b9\u30c8\u30ec\u30b9\u3082\u3001\u30b7\u30ef\u306e\u5f62\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u3001\u9854\u306e\u4e00\u6642\u7684\u306a\u6298\u308a\u76ee\u304c\u7d2b\u5916\u7dda\u306e\u7167\u5c04\u306b\u3088\u3063\u3066\u6052\u4e45\u7684\u306a\u30b7\u30ef\u306b\u5909\u308f\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u4eba\u9593\u3067\u3082\u4f3c\u305f\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u50cd\u3044\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/24869933_s.jpg\" alt=\"\u65e5\u5098\u5973\u5b50\" class=\"wp-image-4519\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/24869933_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/24869933_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u9ad8\u9f62\u8005\u306e\u76ae\u819a\u8001\u5316\u3068\u751f\u6d3b\u7fd2\u6163<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u5730\u57df\u4f4f\u6c11\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5ba2\u89b3\u7684\u30a4\u30e1\u30fc\u30b8\u89e3\u6790<\/h3>\n\n\n\n<p>Asakura\u3089\uff082009\u5e74\uff09\u306f\u3001\u7fa4\u99ac\u770c\u9ad8\u5d0e\u5e02\u5009\u6e15\u753a\u3068\u3044\u3046\u5c71\u9593\u5730\u57df\u306b\u4f4f\u3080\u9ad8\u9f62\u8005\uff0865\u6b73\u4ee5\u4e0a\uff09\u306e\u3046\u3061\u3001\u5730\u57df\u306e\u533b\u7642\u8abf\u67fb\u306b\u5354\u529b\u53ef\u80fd\u306a802\u540d\uff08\u7537\u6027341\u540d\u3001\u5973\u6027461\u540d\uff09\u3092\u5bfe\u8c61\u306b\u3001\u76ae\u819a\u306e\u52a0\u9f62\u5909\u5316\u3068\u751f\u6d3b\u7fd2\u6163\u3068\u306e\u95a2\u4fc2\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u4e3b\u306b\u8fb2\u6751\u5730\u57df\u3067\u4e00\u751f\u3092\u904e\u3054\u3057\u305f\u9ad8\u9f62\u8005\u3092\u5bfe\u8c61\u306b\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u7d2b\u5916\u7dda\u66dd\u9732\u306a\u3069\u306e\u5730\u57df\u5dee\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u305f\u975e\u5e38\u306b\u8cb4\u91cd\u306a\u30c7\u30fc\u30bf\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u9854\u306e\u76ae\u819a\u72b6\u614b\u306f\u3001Beauty Imaging System\uff08BIS\uff09\u3068\u3044\u3046\u30c7\u30b8\u30bf\u30eb\u753b\u50cf\u89e3\u6790\u88c5\u7f6e\u3092\u7528\u3044\u3066\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002BIS\u306f\u3001\u9ad8\u89e3\u50cf\u5ea6\u306e\u5199\u771f\u3092\u6a19\u6e96\u5316\u3055\u308c\u305f\u30e9\u30a4\u30c6\u30a3\u30f3\u30b0\u6761\u4ef6\u4e0b\u3067\u64ae\u5f71\u3057\u3001\u753b\u50cf\u89e3\u6790\u30bd\u30d5\u30c8\u3092\u7528\u3044\u3066\u8001\u5316\u306e4\u3064\u306e\u4e3b\u8981\u306a\u5146\u5019\u2015\u2015\u8272\u7d20\u6591\uff08hyperpigmented macules\uff09\u3001\u6bdb\u7a74\u306e\u958b\u304d\uff08visible pores\uff09\u3001\u808c\u306e\u8cea\u611f\uff08texture irregularities\uff09\u3001\u30b7\u30ef\uff08wrinkles\uff09\u2015\u2015\u306e\u7a0b\u5ea6\u3092\u9854\u306e\u9762\u7a4d\u6bd4\u7387\u3068\u3057\u3066\u5b9a\u91cf\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u89e3\u6790\u306e\u7d50\u679c\u3001\u7537\u6027\u306f\u5973\u6027\u3088\u308a\u3082\u5168\u822c\u7684\u306b\u8272\u7d20\u6591\u3001\u6bdb\u7a74\u3001\u808c\u306e\u3056\u3089\u3064\u304d\u304c\u76ee\u7acb\u3061\u307e\u3057\u305f\u304c\u3001\u30b7\u30ef\u306e\u6df1\u3055\u306b\u95a2\u3057\u3066\u306f\u6027\u5225\u306b\u3088\u308b\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5973\u6027\u3067\u306f\u52a0\u9f62\u306b\u4f34\u3063\u3066\u3059\u3079\u3066\u306e\u76ae\u819a\u8001\u5316\u6307\u6a19\u304c\u5897\u52a0\u3057\u305f\u4e00\u65b9\u3001\u7537\u6027\u3067\u306f\u7279\u306b\u30b7\u30ef\u306e\u91cd\u75c7\u5ea6\u304c\u5e74\u9f62\u3068\u3068\u3082\u306b\u9855\u8457\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/24467133_s.jpg\" alt=\"\u6bdb\u7a74\" class=\"wp-image-4511\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/24467133_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/24467133_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u55ab\u7159\u3068\u7d2b\u5916\u7dda\u9632\u5fa1\u306e\u5f71\u97ff<\/h3>\n\n\n\n<p>\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u56e0\u5b50\u306e\u4e2d\u3067\u6700\u3082\u5f37\u304f\u76ae\u819a\u72b6\u614b\u306b\u5f71\u97ff\u3057\u3066\u3044\u305f\u306e\u306f\u3001\u55ab\u7159\u3068\u7d2b\u5916\u7dda\u5bfe\u7b56\u3067\u3057\u305f\u3002\u7537\u6027\u55ab\u7159\u8005\u3067\u306f\u3001\u975e\u55ab\u7159\u8005\u306b\u6bd4\u3079\u3066\u8272\u7d20\u6591\u306e\u9762\u7a4d\u304c\u5e73\u5747\u3067+1.34\u3001\u6bdb\u7a74\u304c+0.43\u3001\u808c\u306e\u3056\u3089\u3064\u304d\u304c+0.46\u30dd\u30a4\u30f3\u30c8\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u5973\u6027\u3067\u3082\u3001\u55ab\u7159\u8005\u3067\u306f\u6bdb\u7a74\uff08+0.88\uff09\u3068\u808c\u8cea\uff08+0.86\uff09\u306e\u60aa\u5316\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001\u65e5\u713c\u3051\u6b62\u3081\u3084\u30d5\u30a1\u30f3\u30c7\u30fc\u30b7\u30e7\u30f3\u306a\u3069\u306e\u5149\u9632\u5fa1\u88fd\u54c1\u3092\u65e5\u5e38\u7684\u306b\u4f7f\u7528\u3057\u3066\u3044\u308b\u4eba\u3067\u306f\u3001\u76ae\u819a\u306e\u8001\u5316\u6307\u6a19\u304c\u660e\u3089\u304b\u306b\u826f\u597d\u3067\u3057\u305f\u3002\u305f\u3068\u3048\u3070\u3001\u7537\u6027\u3067\u306f\u8272\u7d20\u6591\u306e\u9762\u7a4d\u304c\u22122.14\u3001\u808c\u306e\u3056\u3089\u3064\u304d\u304c\u22120.75\u6539\u5584\u3057\u3066\u304a\u308a\u3001\u5973\u6027\u3067\u306f\u8272\u7d20\u6591\uff08\u22120.52\uff09\u3001\u6bdb\u7a74\uff08\u22120.29\uff09\u3001\u808c\u8cea\uff08\u22120.22\uff09\u304c\u305d\u308c\u305e\u308c\u6539\u5584\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u4ed6\u306e\u56e0\u5b50\u2015\u2015\u305f\u3068\u3048\u3070\u7d50\u5a5a\u6b74\u3001\u98f2\u9152\u3001\u5b66\u6b74\u3001\u6700\u9577\u8077\u6b74\u3001\u5c4b\u5916\u4f5c\u696d\u306e\u6709\u7121\u306a\u3069\u2015\u2015\u306f\u3001\u76ae\u819a\u306e\u8001\u5316\u6307\u6a19\u3068\u306e\u95a2\u9023\u6027\u304c\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5c4b\u5916\u4f5c\u696d\u306e\u81ea\u5df1\u7533\u544a\u304c\u4e0d\u6b63\u78ba\u3067\u3042\u308b\u53ef\u80fd\u6027\u3084\u3001\u5bfe\u8c61\u5730\u57df\u304c\u540c\u4e00\u5730\u57df\u5185\u3067\u751f\u6d3b\u3057\u3066\u3044\u305f\u305f\u3081\u74b0\u5883\u5dee\u304c\u5c0f\u3055\u304b\u3063\u305f\u3053\u3068\u306a\u3069\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306f\u3001\u76ae\u819a\u8001\u5316\u304c\u5358\u306b\u52a0\u9f62\u306e\u7d50\u679c\u3067\u306f\u306a\u304f\u3001\u65e5\u5e38\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u7279\u306b\u55ab\u7159\u3068\u7d2b\u5916\u7dda\u5bfe\u7b56\u304c\u76ae\u819a\u5065\u5eb7\u306e\u9375\u3068\u306a\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/4242393_s.jpg\" alt=\"\u30bf\u30d0\u30b3\u5973\u6027\" class=\"wp-image-4512\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/4242393_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/4242393_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u53cc\u5b50\u7814\u7a76\u306b\u3088\u308b\u74b0\u5883\u3068\u907a\u4f1d\u306e\u5f71\u97ff\u5206\u6790<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e00\u5375\u6027\u53cc\u751f\u5150\u3092\u5bfe\u8c61\u3068\u3057\u305f\u808c\u8001\u5316\u7814\u7a76<\/h3>\n\n\n\n<p>Ichibori\u3089\uff082014\u5e74\uff09\u306f\u3001\u76ae\u819a\u8001\u5316\u304c\u3069\u306e\u7a0b\u5ea6\u307e\u3067\u907a\u4f1d\u306b\u5de6\u53f3\u3055\u308c\u3001\u307e\u305f\u3069\u306e\u7a0b\u5ea6\u307e\u3067\u74b0\u5883\u8981\u56e0\u306b\u5f71\u97ff\u3055\u308c\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u65e5\u672c\u5168\u56fd\u304b\u3089\u52df\u96c6\u3057\u305f40\u301c87\u6b73\u306e\u4e00\u5375\u6027\u53cc\u751f\u5150\uff08monozygotic twins\uff0967\u7d44\u3092\u5bfe\u8c61\u306b\u3001VISIA\u00ae Complexion Analysis System\u3092\u7528\u3044\u305f\u9ad8\u7cbe\u5ea6\u306a\u753b\u50cf\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u4e00\u5375\u6027\u53cc\u751f\u5150\u306f\u907a\u4f1d\u60c5\u5831\u304c\u307b\u307c\u5b8c\u5168\u306b\u4e00\u81f4\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3069\u308c\u307b\u3069\u808c\u8001\u5316\u306b\u5dee\u304c\u51fa\u308b\u304b\u3092\u8a55\u4fa1\u3059\u308b\u306e\u306b\u7406\u60f3\u7684\u306a\u5bfe\u8c61\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u753b\u50cf\u89e3\u6790\u3067\u306f\u3001\u6591\u70b9\uff08spots\uff09\u3001\u30b7\u30ef\uff08wrinkles\uff09\u3001\u6bdb\u7a74\uff08pores\uff09\u3001\u808c\u306e\u8cea\u611f\uff08texture\uff09\u3001\u7d05\u6591\uff08erythema\uff09\u306e5\u9805\u76ee\u3092\u6e2c\u5b9a\u3057\u3001\u9854\u306e\u5de6\u53f3\u305d\u308c\u305e\u308c\u306e\u30b9\u30b3\u30a2\u3092\u5e73\u5747\u5316\u3057\u3066\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u7d71\u8a08\u89e3\u6790\u306b\u306f\u30a6\u30a3\u30eb\u30b3\u30af\u30bd\u30f3\u7b26\u53f7\u4ed8\u304d\u9806\u4f4d\u691c\u5b9a\uff08Wilcoxon signed-rank test\uff09\u304a\u3088\u3073\u30d4\u30a2\u30bd\u30f3\u306e\u76f8\u95a2\u4fc2\u6570\uff08Pearson\u2019s correlation coefficient\uff09\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"426\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32128392_s.jpg\" alt=\"\u808c\u306e\u8cea\u611f\" class=\"wp-image-4513\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32128392_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32128392_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u306a\u7d50\u679c\u3068\u89e3\u91c8<\/h3>\n\n\n\n<p>\u53cc\u5b50\u9593\u3067\u6700\u3082\u5dee\u304c\u5927\u304d\u304b\u3063\u305f\u306e\u306f\u808c\u306e\u8cea\u611f\uff08texture\uff09\u3067\u3001\u5e74\u9f62\u304c\u4e0a\u304c\u308b\u306b\u3064\u308c\u3066\u53cc\u5b50\u9593\u3067\u306e\u30b9\u30b3\u30a2\u5dee\u304c\u6709\u610f\u306b\u5e83\u304c\u308b\u50be\u5411\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\uff08p = 0.03\uff09\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u808c\u306e\u8cea\u611f\u304c\u9577\u5e74\u306e\u74b0\u5883\u56e0\u5b50\uff08\u7d2b\u5916\u7dda\u3001\u30b9\u30ad\u30f3\u30b1\u30a2\u3001\u751f\u6d3b\u7fd2\u6163\u306a\u3069\uff09\u306b\u5f37\u304f\u5f71\u97ff\u3055\u308c\u3084\u3059\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u55ab\u7159\u6b74\u304c\u7570\u306a\u308b\u53cc\u5b50\u9593\u3067\u306f\u3001\u55ab\u7159\u3057\u3066\u3044\u308b\u65b9\u304c\u660e\u3089\u304b\u306b\u30b7\u30ef\u3068\u808c\u8cea\u306e\u30b9\u30b3\u30a2\u304c\u60aa\u5316\u3057\u3066\u3044\u307e\u3057\u305f\uff08p = 0.04\uff09\u3002\u307e\u305f\u3001\u65e5\u713c\u3051\u6b62\u3081\u3084\u30d5\u30a1\u30f3\u30c7\u30fc\u30b7\u30e7\u30f3\u3092\u4f7f\u7528\u3057\u3066\u3044\u306a\u3044\u65b9\u304c\u3001\u4f7f\u7528\u3057\u3066\u3044\u308b\u53cc\u5b50\u3088\u308a\u3082\u30b7\u30ef\u306e\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u50be\u5411\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08p = 0.03\uff09\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u4ed6\u306e\u8981\u56e0\uff08\u98f2\u9152\u3001\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u3001\u65e5\u7167\u66dd\u9732\u6b74\u3001\u7d50\u5a5a\u6b74\u3001BMI\u306a\u3069\uff09\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306e\u5236\u9650\u3082\u3042\u308a\u3001\u6709\u610f\u306a\u95a2\u9023\u6027\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305f\u3060\u3057\u3001BMI\u5dee\u304c4\u4ee5\u4e0a\u3042\u308b\u53cc\u5b5011\u7d44\u3067\u306f\u3001BMI\u304c\u9ad8\u3044\u65b9\u306e\u808c\u8cea\u3068\u30b7\u30ef\u30b9\u30b3\u30a2\u304c\u3084\u3084\u60aa\u5316\u3057\u3066\u3044\u308b\u50be\u5411\u304c\u898b\u3089\u308c\u3001\u4f53\u91cd\u306e\u7ba1\u7406\u3082\u8001\u5316\u306b\u4e00\u5b9a\u306e\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u808c\u8001\u5316\u306f\u907a\u4f1d\u3060\u3051\u3067\u306a\u304f\u3001\u9577\u5e74\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3084\u5916\u7684\u74b0\u5883\u306e\u84c4\u7a4d\u306b\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u78ba\u306b\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/31518292_s-1.jpg\" alt=\"\u65e5\u713c\u3051\u6b62\u3081\" class=\"wp-image-4514\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31518292_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31518292_s-1-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u5149\u8001\u5316\u306b\u95a2\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u7cd6\u5316\u53cd\u5fdc\uff08Glycation\uff09\u3068\u76ae\u819a\u69cb\u9020\u306e\u5909\u5316<\/h3>\n\n\n\n<p>Ichihashi\u3089\uff082011\u5e74\uff09\u306f\u3001\u8001\u5316\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3059\u308b\u300c\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\uff08glycation stress\uff09\u300d\u306e\u76ae\u819a\u3078\u306e\u5f71\u97ff\u306b\u7126\u70b9\u3092\u5f53\u3066\u307e\u3057\u305f\u3002\u7cd6\u5316\u3068\u306f\u3001\u7cd6\uff08\u7279\u306b\u9084\u5143\u7cd6\uff1breducing sugars\uff09\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u9175\u7d20\u3092\u4ecb\u3055\u305a\u306b\u53cd\u5fdc\u3057\u3001\u6700\u7d42\u7684\u306b\u300cAGEs\uff08Advanced Glycation End Products\uff1b\u6700\u7d42\u7cd6\u5316\u7523\u7269\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u52a3\u5316\u7269\u8cea\u3092\u4f5c\u308b\u904e\u7a0b\u3092\u6307\u3057\u307e\u3059\u3002\u3053\u306e\u53cd\u5fdc\u306f\u4f53\u5185\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u306a\u3069\u306e\u69cb\u9020\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3082\u8d77\u3053\u308a\u3001\u76ae\u819a\u306e\u5f3e\u529b\u6027\u3084\u900f\u660e\u611f\u3092\u8457\u3057\u304f\u640d\u306a\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>AGEs\u306f\u3001N\u03b5-(carboxymethyl)lysine\uff08CML\uff09\u3084\u30da\u30f3\u30c8\u30b7\u30b8\u30f3\uff08pentosidine\uff09\u306a\u3069\u3092\u542b\u307f\u3001\u76ae\u819a\u306e\u4e2d\u3067\u4ea4\u5dee\u7d50\u5408\u3092\u5f62\u6210\u3057\u3001\u7e4a\u7dad\u306e\u786c\u5316\u3084\u5909\u5f62\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u808c\u306b\u30b7\u30ef\u3084\u9ec4\u5909\uff08\u808c\u306e\u9ec4\u8272\u5473\uff09\u306a\u3069\u304c\u751f\u3058\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001AGEs\u306fRAGE\uff08Receptor for Advanced Glycation End Products\uff09\u3068\u3044\u3046\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u3001\u708e\u75c7\u3092\u4fc3\u9032\u3059\u308bNF-\u03baB\u7d4c\u8def\u306a\u3069\u306e\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6d3b\u6027\u5316\u3055\u305b\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084MMP\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\uff09\u306e\u767a\u73fe\u304c\u5897\u52a0\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5206\u89e3\u304c\u9032\u884c\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32103799_s.jpg\" alt=\"\u65e5\u713c\u3051\u6b62\u3081\" class=\"wp-image-4515\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32103799_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32103799_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d2b\u5916\u7dda\u3068\u7cd6\u5316\u306e\u76f8\u4e57\u52b9\u679c<\/h3>\n\n\n\n<p>UV-B\u3084UV-A\u306a\u3069\u306e\u7d2b\u5916\u7dda\u306f\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08reactive oxygen species; ROS\uff09\u3092\u751f\u6210\u3057\u3001\u7cd6\u5316\u3084\u708e\u75c7\u3092\u3055\u3089\u306b\u4fc3\u9032\u3057\u307e\u3059\u3002UV-B\u306f\u8868\u76ae\u7d30\u80de\u306b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-1\u03b1\u3001IL-6\u3001TNF\u03b1\u306a\u3069\uff09\u3092\u8a98\u5c0e\u3057\u3001\u771f\u76ae\u306e\u7dda\u7dad\u82bd\u7d30\u80de\u306bMMP-1\u3001-3\u3001-9\u3092\u7523\u751f\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u3092\u5206\u89e3\u3057\u3001\u3057\u308f\u306e\u5f62\u6210\u3092\u52a0\u901f\u3055\u305b\u307e\u3059\u3002<\/p>\n\n\n\n<p>AGE\u306e\u84c4\u7a4d\u3092\u975e\u4fb5\u8972\u7684\u306b\u6e2c\u5b9a\u3059\u308b\u624b\u6bb5\u3068\u3057\u3066\u3001AGE Reader\u2122\u306a\u3069\u306e\u6a5f\u5668\u306b\u3088\u308b\u76ae\u819a\u306e\u81ea\u5bb6\u86cd\u5149\uff08autofluorescence; AF\uff09\u6e2c\u5b9a\u304c\u3042\u308a\u307e\u3059\u3002\u65e5\u672c\u4eba\u5973\u6027136\u540d\u3092\u5bfe\u8c61\u306b\u3057\u305f\u7814\u7a76\u3067\u306f\u3001AF\u306f\u5e74\u9f62\u3068\u3068\u3082\u306b\u6709\u610f\u306b\u4e0a\u6607\u3057\u3066\u304a\u308a\uff08r = 0.603, p &lt; 0.001\uff09\u3001\u8001\u5316\u306e\u4fe1\u983c\u3067\u304d\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/31512938_s.jpg\" alt=\"\u7d2b\u5916\u7dda\" class=\"wp-image-4516\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31512938_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31512938_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e88\u9632\u3068\u6cbb\u7642\u306e\u53ef\u80fd\u6027<\/h3>\n\n\n\n<p>\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u4e88\u9632\u7b56\u306b\u306f\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3001\u7b4b\u8089\u91cf\u306e\u7dad\u6301\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u5411\u4e0a\u306e\u305f\u3081\uff09\u3001\u4f4eGI\u98df\u54c1\u306e\u6442\u53d6\u3001\u7802\u7cd6\u30fb\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5236\u9650\u3001\u305d\u3057\u3066\u6bce\u65e5\u306e\u7d2b\u5916\u7dda\u5bfe\u7b56\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u306f\u3001AGE\u5f62\u6210\u6291\u5236\u5264\uff08\u4f8b\uff1a\u30a2\u30df\u30ce\u30b0\u30a2\u30cb\u30b8\u30f3\uff09\u3001AGE\u5206\u89e3\u4fc3\u9032\u7269\u8cea\u3001RAGE\u963b\u5bb3\u5264\u306a\u3069\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30ab\u30e2\u30df\u30fc\u30eb\u3001\u30c9\u30af\u30c0\u30df\u3001\u30d6\u30c9\u30a6\u8449\u306a\u3069\u306e\u690d\u7269\u62bd\u51fa\u7269\u304cAGE\u751f\u6210\u6291\u5236\u52b9\u679c\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u306b\u3088\u308a\u81e8\u5e8a\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>RAGE\u7d4c\u8def\u306e\u8abf\u6574\u3082\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u7d30\u80de\u819c\u306b\u7d50\u5408\u3057\u305fRAGE\u3092\u5206\u89e3\u9175\u7d20\uff08MMP-9\u3084ADAM-10\uff09\u306b\u3088\u3063\u3066\u53ef\u6eb6\u578bRAGE\uff08sRAGE\uff09\u3078\u5909\u63db\u3059\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u6027\u30b7\u30b0\u30ca\u30eb\u3092\u906e\u65ad\u3057\u3001\u7d44\u7e54\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u6291\u5236\u3059\u308b\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3082\u63d0\u6848\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32126820_s.jpg\" alt=\"\u7d2b\u5916\u7dda\" class=\"wp-image-4517\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32126820_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32126820_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 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style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/23442746_s.jpg\" alt=\"\u76ae\u819a\" class=\"wp-image-4444\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/23442746_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/23442746_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u9854\u306e\u8001\u5316,\u30b7\u30ef,\u305f\u308b\u307f,\u65e5\u672c\u4eba\u5973\u6027,\u767d\u4eba\u5973\u6027,\u808c\u306e\u9055\u3044,\u30a2\u30b8\u30a2\u5973\u6027,\u7d2b\u5916\u7dda,\u751f\u6d3b\u7fd2\u6163,\u30b9\u30ad\u30f3\u30b1\u30a2,\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9,\u5149\u8001\u5316,\u808c\u306e\u5f3e\u529b,\u30b3\u30e9\u30fc\u30b2\u30f3,\u30a8\u30e9\u30b9\u30c1\u30f3,\u8868\u60c5\u30b8\u30ef,\u6587\u5316\u306e\u9055\u3044,\u65e5\u713c\u3051\u6b62\u3081,\u30b9\u30ad\u30f3\u30a8\u30a4\u30b8\u30f3\u30b0,\u808c\u306e\u69cb\u9020,\u808c\u306e\u79d1\u5b66,\u808c\u8001\u5316\u306e\u4e88\u9632,\u9ad8\u6821\u751f\u5411\u3051\u7f8e\u5bb9,\u808c\u306e\u672a\u6765,\u5730\u57df\u5dee,\u8868\u76ae,\u771f\u76ae,\u808c\u306e\u8272,\u808c\u8cea,\u7d2b\u5916\u7dda\u5bfe\u7b56,\u65e5\u5e38\u30b1\u30a2,\u808c\u306e\u6bd4\u8f03\u7814\u7a76,\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af<\/sup><\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/23443899_s.jpg\" alt=\"\u308f\u305f\u304f\u3057\u306e\u6307\u3092\u898b\u3066\u304f\u3060\u3055\u3044\" class=\"wp-image-4438\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/23443899_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/23443899_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1111\/j.1467-2494.2004.00245_5.x\">Tsukahara, K., Fujimura, T., Yoshida, Y., Kitahara, T., Hotta, M., Moriwaki, S., Witt, P. S., Simion, F. A., &amp; Takema, Y. (2004). Comparison of age\u2010related changes in wrinkling and sagging of the skin in Caucasian females and in Japanese females.&nbsp;<em>International Journal of Cosmetic Science<\/em>,&nbsp;<em>26<\/em>(6), 314\u2013314. https:\/\/doi.org\/10.1111\/j.1467-2494.2004.00245_5.x<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.jdermsci.2007.03.007\">Tsukahara, K., Sugata, K., Osanai, O., Ohuchi, A., Miyauchi, Y., Takizawa, M., Hotta, M., &amp; Kitahara, T. (2007). Comparison of age-related changes in facial wrinkles and sagging in the skin of Japanese, Chinese and Thai women. Journal of Dermatological Science, 47(1), 19\u201328. https:\/\/doi.org\/10.1016\/j.jdermsci.2007.03.007<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.2188\/jea.JE20090031\">Asakura, K., Nishiwaki, Y., Milojevic, A., Michikawa, T., Kikuchi, Y., Nakano, M., Iwasawa, S., Hillebrand, G., Miyamoto, K., Ono, M., Kinjo, Y., Akiba, S., &amp; Takebayashi, T. (2009). Lifestyle factors and visible skin aging in a population of japanese elders. <em>Journal of Epidemiology<\/em>, <em>19<\/em>(5), 251\u2013259. https:\/\/doi.org\/10.2188\/jea.JE20090031<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1111\/jocd.12081\">Ichibori, R., Fujiwara, T., Tanigawa, T., Kanazawa, S., Shingaki, K., Torii, K., Tomita, K., Yano, K., Osaka Twin Research Group, Sakai, Y., &amp; Hosokawa, K. (2014). Objective assessment of facial skin aging and the associated environmental factors in Japanese monozygotic twins. <em>Journal of Cosmetic Dermatology<\/em>, <em>13<\/em>(2), 158\u2013163. https:\/\/doi.org\/10.1111\/jocd.12081<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3793\/jaam.8.23\" target=\"_blank\" rel=\"noreferrer noopener\">Ichihashi, M., Yagi, M., Nomoto, K., &amp; Yonei, Y. (2011). Glycation stress and photo-aging in skin. <em>ANTI-AGING MEDICINE<\/em>, <em>8<\/em>(3), 23\u201329. https:\/\/doi.org\/10.3793\/jaam.8.23<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"\u4eba\u7a2e\u3084\u5730\u57df\u306b\u3088\u308b\u9854\u306e\u8001\u5316\u306e\u9055\u3044 \u767d\u4eba\u5973\u6027\u3068\u65e5\u672c\u4eba\u5973\u6027\u306b\u304a\u3051\u308b\u30b7\u30ef\u3068\u305f\u308b\u307f\u306e\u6bd4\u8f03 2004\u5e74\u306bTsukahara\u3089\u304c\u884c\u3063\u305f\u7814\u7a76\u3067\u306f\u3001\u30a2\u30e1\u30ea\u30ab\u30fb\u30aa\u30cf\u30a4\u30aa\u5dde\u30b7\u30f3\u30b7\u30ca\u30c6\u30a3\u306b\u4f4f\u3080\u5065\u5eb7\u306a\u767d\u4eba\u5973\u602785\u540d\u3068\u3001\u65e5\u672c\u30fb\u6771\u4eac\u306b\u4f4f\u3080\u5065\u5eb7\u306a\u65e5\u672c\u4eba [&hellip;]","protected":false},"author":44,"featured_media":4518,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[94,112,95,110,90,120,100,118,108,96,99,91,111,119,89,98,106,102,15,105,103,109,117,107,115,93,104,101,114,113,92,97],"class_list":["post-4503","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-derma","tag-94","tag-112","tag-95","tag-110","tag-90","tag-120","tag-100","tag-118","tag-108","tag-96","tag-99","tag-91","tag-111","tag-119","tag-89","tag-98","tag-106","tag-102","tag-uv-protection","tag-105","tag-103","tag-109","tag-117","tag-107","tag-115","tag-93","tag-104","tag-101","tag-114","tag-113","tag-92","tag-97"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/posts\/4503","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/users\/44"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/comments?post=4503"}],"version-history":[{"count":5,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/posts\/4503\/revisions"}],"predecessor-version":[{"id":4688,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/posts\/4503\/revisions\/4688"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/media\/4518"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/media?parent=4503"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/categories?post=4503"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/tags?post=4503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}