{"id":4616,"date":"2025-03-31T09:06:17","date_gmt":"2025-03-31T00:06:17","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/?p=4616"},"modified":"2025-04-24T17:39:31","modified_gmt":"2025-04-24T08:39:31","slug":"keloid","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/derma\/keloid\/","title":{"rendered":"\u306a\u3093\u3067\u50b7\u3042\u3068\u304c\u3075\u304f\u3089\u3080\u306e\uff1f\u30b1\u30ed\u30a4\u30c9\u3068\u80a5\u539a\u6027\u7622\u75d5\u306e\u3061\u304c\u3044\u3092\u3084\u3055\u3057\u304f\u89e3\u8aac"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u30b1\u30ed\u30a4\u30c9\u3068\u80a5\u539a\u6027\u7622\u75d5\u306e\u7406\u89e3<\/h2>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\uff08Keloid\uff09\u3068\u80a5\u539a\u6027\u7622\u75d5\uff08Hypertrophic scar\uff09\u306f\u3001\u3044\u305a\u308c\u3082\u5275\u50b7\u6cbb\u7652\uff08wound healing\uff09\u306e\u7570\u5e38\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u76ae\u819a\u306e\u7dda\u7dad\u5897\u6b96\u6027\u75be\u60a3\uff08fibroproliferative disorders\uff09\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3068\u3082\u306b\u904e\u5270\u306a\u30b3\u30e9\u30fc\u30b2\u30f3\uff08collagen\uff09\u7523\u751f\u3092\u4f34\u3044\u3001\u75db\u307f\u3084\u304b\u3086\u307f\u306a\u3069\u306e\u4e0d\u5feb\u306a\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u81e8\u5e8a\u7684\u306a\u898b\u305f\u76ee\u3001\u7d44\u7e54\u5b66\u7684\u7279\u5fb4\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u306b\u306f\u5927\u304d\u306a\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/28436579_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4621\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/28436579_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/28436579_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b1\u30ed\u30a4\u30c9\u306e\u5b9a\u7fa9\u3068\u7279\u5fb4<\/h3>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306f\u3001\u5275\u50b7\u304c\u6cbb\u7652\u3059\u308b\u904e\u7a0b\u3067\u751f\u3058\u308b\u7570\u5e38\u306a\u76ae\u819a\u306e\u5897\u6b96\u3067\u3042\u308a\u3001\u672c\u6765\u306e\u50b7\u306e\u7bc4\u56f2\u3092\u8d85\u3048\u3066\u786c\u304f\u9686\u8d77\u3057\u305f\u7d44\u7e54\u304c\u62e1\u5927\u3057\u3066\u3044\u304f\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002\u81ea\u7136\u306b\u9000\u7e2e\u3059\u308b\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u306a\u304f\u3001\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u5f90\u3005\u306b\u5897\u5927\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u898b\u305f\u76ee\u306f\u8d64\u307f\u3084\u8272\u7d20\u6c88\u7740\uff08hyperpigmentation\uff09\u3092\u4f34\u3046\u3053\u3068\u304c\u3042\u308a\u3001\u7d50\u7bc0\u72b6\uff08nodular\uff09\u307e\u305f\u306f\u6591\u72b6\uff08plaque-like\uff09\u306b\u5e83\u304c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7570\u5e38\u306a\u5897\u6b96\u306f\u3001\u708e\u75c7\u671f\uff08inflammation\uff09\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u5897\u6b96\u671f\uff08fibroblast proliferation phase\uff09\u3001\u6210\u719f\u671f\uff08maturation phase\uff09\u3068\u3044\u3046\u5275\u50b7\u6cbb\u7652\u306e\u4e09\u76f8\u306e\u3046\u3061\u3001\u7279\u306b\u5897\u6b96\u671f\u304c\u904e\u5270\u304b\u3064\u6301\u7d9a\u7684\u306b\u306a\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/4030754_s.jpg\" alt=\"\u3072\u3068\" class=\"wp-image-4613\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/4030754_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/4030754_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">\u75ab\u5b66\u3068\u30ea\u30b9\u30af\u8981\u56e0<\/h4>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306f\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u3001\u30a2\u30b8\u30a2\u7cfb\u3001\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u306e\u4eba\u3005\u306a\u3069\u3001\u76ae\u819a\u306e\u8272\u304c\u6fc3\u3044\u96c6\u56e3\u3067\u3088\u308a\u9ad8\u3044\u767a\u75c7\u7387\u3092\u793a\u3057\u3001\u767a\u75c7\u7387\u306f4.5%\u301c16%\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u601d\u6625\u671f\u3084\u598a\u5a20\u4e2d\u306a\u3069\u30db\u30eb\u30e2\u30f3\u5909\u52d5\u306e\u5927\u304d\u3044\u6642\u671f\u306b\u3082\u767a\u75c7\u3057\u3084\u3059\u304f\u3001\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u5834\u5408\u306f\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u307e\u308c\u306b\u3001Rubinstein-Taybi\u75c7\u5019\u7fa4\u3084Goeminne\u75c7\u5019\u7fa4\u306a\u3069\u306e\u907a\u4f1d\u6027\u75be\u60a3\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u6a5f\u68b0\u7684\u523a\u6fc0\u3084\u708e\u75c7\u3001\u8840\u5727\u306e\u4e0a\u6607\uff08\u9ad8\u8840\u5727\uff09\u3082\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/3625224_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4622\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/3625224_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/3625224_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">\u81e8\u5e8a\u7684\u7279\u5fb4\u3068\u7d4c\u904e<\/h4>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306f\u3001\u76ae\u819a\u306e\u5916\u50b7\u5f8c1\u301c12\u30f6\u6708\u4ee5\u5185\u306b\u751f\u3058\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u3054\u304f\u8efd\u5fae\u306a\u50b7\uff08\u305f\u3068\u3048\u3070\u866b\u523a\u3055\u308c\u3084\u30cb\u30ad\u30d3\uff09\u3067\u3082\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u597d\u767a\u90e8\u4f4d\u306f\u3001\u4e09\u89d2\u7b4b\u90e8\uff08deltoid area\uff09\u3001\u80f8\u90e8\u4e2d\u592e\uff08presternal chest\uff09\u3001\u80cc\u4e0a\u90e8\uff08upper back\uff09\u3001\u304a\u3088\u3073\u8033\u305f\u3076\uff08earlobes\uff09\u3067\u3059\u300286%\u306e\u60a3\u8005\u304c\u304b\u3086\u307f\u300146%\u304c\u75db\u307f\u3092\u8a34\u3048\u308b\u3068\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u4ed6\u306b\u3082\u5727\u75db\u3084\u713c\u3051\u308b\u3088\u3046\u306a\u611f\u899a\u3092\u4f34\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u898b\u305f\u76ee\u306e\u554f\u984c\u3060\u3051\u3067\u306a\u304f\u3001\u3053\u3046\u3057\u305f\u75c7\u72b6\u304c\u65e5\u5e38\u751f\u6d3b\u306b\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u3053\u3068\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/22126248_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4623\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/22126248_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/22126248_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u80a5\u539a\u6027\u7622\u75d5\u3068\u306e\u9055\u3044<\/h3>\n\n\n\n<p>\u80a5\u539a\u6027\u7622\u75d5\u306f\u3001\u50b7\u306e\u7bc4\u56f2\u5185\u306b\u3068\u3069\u307e\u308b\u76db\u308a\u4e0a\u304c\u3063\u305f\u8d64\u3044\u7622\u75d5\u3067\u3001\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u81ea\u7136\u306b\u9000\u8272\u3057\u3001\u5e73\u5766\u306b\u306a\u3063\u3066\u67d4\u3089\u304b\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u30b1\u30ed\u30a4\u30c9\u3068\u7570\u306a\u308a\u3001\u5468\u56f2\u306e\u6b63\u5e38\u306a\u76ae\u819a\u306b\u306f\u62e1\u5927\u305b\u305a\u3001\u6cbb\u7642\u306b\u3082\u6bd4\u8f03\u7684\u3088\u304f\u53cd\u5fdc\u3057\u307e\u3059\u3002\u7d44\u7e54\u5b66\u7684\u306b\u306f\u3001\u7e4a\u7dad\u82bd\u7d30\u80de\u306e\u5897\u52a0\u3084\u5e73\u884c\u306b\u4e26\u3076\u30b3\u30e9\u30fc\u30b2\u30f3\u7e4a\u7dad\u304c\u7279\u5fb4\u3067\u3001\u30b1\u30ed\u30a4\u30c9\u306b\u7279\u6709\u306e\u300c\u30b1\u30ed\u30a4\u30c9\u30b3\u30e9\u30fc\u30b2\u30f3\uff08keloidal collagen\uff09\u300d\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/2957781_s.jpg\" alt=\"\u3072\u3068\" class=\"wp-image-4610\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/2957781_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/2957781_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d44\u7e54\u5b66\u7684\u7279\u5fb4\u3068\u8a3a\u65ad\u306e\u30dd\u30a4\u30f3\u30c8<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b1\u30ed\u30a4\u30c9\u306e\u7d44\u7e54\u50cf<\/h3>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306f\u9855\u5fae\u93e1\u4e0b\u3067\u7279\u6709\u306e\u592a\u304f\u785d\u5b50\u69d8\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u675f\uff08keloidal collagen\uff09\u3092\u793a\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u7d0455%\u306e\u75c7\u4f8b\u3067\u78ba\u8a8d\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u4ed6\u306e\u7279\u5fb4\u3068\u3057\u3066\u306f\u3001\u4e73\u982d\u771f\u76ae\u4e0b\u306e\u300c\u820c\u72b6\u306e\u524d\u9032\u7aef\uff08tongue-like advancing edge\uff09\u300d\u3001\u4e0a\u90e8\u7db2\u72b6\u771f\u76ae\u306b\u304a\u3051\u308b\u6c34\u5e73\u7dda\u7dad\u5e2f\u3001\u6df1\u90e8\u771f\u76ae\u306e\u7b4b\u819c\u69d8\u5e2f\uff08fascia-like band\uff09\u306a\u3069\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u8a3a\u65ad\u306b\u6709\u7528\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/31663059_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4624\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31663059_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31663059_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d30\u80de\u30fb\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u7570\u5e38<\/h3>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u3067\u306f\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u7570\u5e38\u5897\u6b96\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08apoptosis\uff1a\u7d30\u80de\u306e\u81ea\u7136\u6b7b\uff09\u306e\u6291\u5236\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u904e\u5270\u7523\u751f\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u30b1\u30ed\u30a4\u30c9\u7d44\u7e54\u3067\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u304c\u6b63\u5e38\u76ae\u819a\u306e20\u500d\u3001\u80a5\u539a\u6027\u7622\u75d5\u306e3\u500d\u306b\u9054\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f62\u8cea\u8ee2\u63db\u5897\u6b96\u56e0\u5b50\u03b2\uff08TGF-\u03b2\uff09\u3084\u8840\u5c0f\u677f\u7531\u6765\u6210\u9577\u56e0\u5b50\uff08PDGF\uff09\u306e\u904e\u5270\u767a\u73fe\u304c\u3053\u3046\u3057\u305f\u7dda\u7dad\u5316\u306e\u4ea2\u9032\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"426\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32128392_s-1.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4625\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32128392_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32128392_s-1-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u4ed6\u75be\u60a3\u3068\u306e\u9451\u5225<\/h3>\n\n\n\n<p>\u901a\u5e38\u306f\u8996\u8a3a\u3067\u8a3a\u65ad\u53ef\u80fd\u3067\u3059\u304c\u3001\u5916\u89b3\u304c\u5178\u578b\u7684\u3067\u306a\u3044\u5834\u5408\u306b\u306f\u751f\u691c\uff08biopsy\uff09\u3092\u884c\u3044\u307e\u3059\u3002\u9451\u5225\u8a3a\u65ad\u306b\u306f\u3001\u80a5\u539a\u6027\u7622\u75d5\u306e\u307b\u304b\u3001\u76ae\u819a\u7dda\u7dad\u816b\uff08dermatofibroma\uff09\u3001\u76ae\u819a\u7dda\u7dad\u8089\u816b\u9686\u8d77\u578b\uff08DFSP: dermatofibrosarcoma protuberans\uff09\u3001\u5f37\u76ae\u75c7\uff08scleroderma\uff09\u3001\u30ed\u30dc\u30df\u30b3\u30fc\u30b7\u30b9\uff08lobomycosis\uff09\u306a\u3069\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u30ed\u30dc\u30df\u30b3\u30fc\u30b7\u30b9\u306f\u3001Lacazia loboi\u3068\u3044\u3046\u771f\u83cc\u306b\u3088\u308b\u611f\u67d3\u75c7\u3067\u3001\u5357\u7c73\u306e\u571f\u58cc\u3084\u30a4\u30eb\u30ab\u3068\u306e\u63a5\u89e6\u6b74\u304c\u3042\u308b\u5834\u5408\u306b\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32113661_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4626\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32113661_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32113661_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u767a\u75c7\u306e\u80cc\u666f\u3068\u95a2\u9023\u56e0\u5b50<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u907a\u4f1d\u7684\u30fb\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u8981\u56e0<\/h3>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306b\u306f\u660e\u78ba\u306a\u907a\u4f1d\u7684\u7d20\u56e0\u304c\u3042\u308a\u3001\u3044\u304f\u3064\u304b\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u306b\u3088\u3063\u3066\u3001\u7279\u5b9a\u306e\u4e00\u5869\u57fa\u591a\u578b\uff08SNP: single nucleotide polymorphism\uff09\u304c\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u65e5\u672c\u3067\u306e\u7814\u7a76\u3067\u306f\u3001rs8032158\u306a\u30694\u3064\u306eSNP\u304c\u30b1\u30ed\u30a4\u30c9\u5f62\u6210\u304a\u3088\u3073\u91cd\u75c7\u5ea6\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u300118q21.1\u306b\u5b58\u5728\u3059\u308bSMAD2\u3001SMAD4\u3001SMAD7\u3068\u3044\u3063\u305fTGF-\u03b2\u7d4c\u8def\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5909\u5316\uff08epigenetic modifications\uff09\u3068\u3057\u3066\u306f\u3001DNA\u30e1\u30c1\u30eb\u5316\uff08DNA methylation\uff09\u3084\u975e\u30b3\u30fc\u30c9RNA\uff08non-coding RNA\uff09\u306e\u767a\u73fe\u7570\u5e38\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001miR-199a-5p\u306f\u30b1\u30ed\u30a4\u30c9\u3067\u4f4e\u4e0b\u3057\u3001\u7d30\u80de\u5897\u6b96\u6291\u5236\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u4e00\u65b9\u3001miR-21\u306f\u5897\u52a0\u3057\u3066\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u6291\u5236\u3057\u3001\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u9577\u9396\u975e\u30b3\u30fc\u30c9RNA\uff08lncRNA\uff09\u3082\u95a2\u4e0e\u3057\u3001CACNA1G-AS1\u3084lncRNA-ATB\u306fTGF-\u03b22\u306e\u767a\u73fe\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32089593_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4627\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32089593_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32089593_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u6a5f\u68b0\u7684\u5f35\u529b\u3068\u76ae\u819a\u7dca\u5f35<\/h3>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306e\u767a\u75c7\u90e8\u4f4d\u306f\u3001\u65e5\u5e38\u7684\u306b\u5f15\u3063\u5f35\u3089\u308c\u308b\u90e8\u4f4d\uff08\u80f8\u90e8\u3001\u80a9\u3001\u984e\u3001\u8033\u306a\u3069\uff09\u306b\u96c6\u4e2d\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u76ae\u819a\u306e\u7dca\u5f35\uff08mechanical tension\uff09\u304c\u5275\u50b7\u6cbb\u7652\u306e\u904e\u7a0b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u6d3b\u6027\u3084\u708e\u75c7\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u3067\u3059\u3002\u53cd\u5bfe\u306b\u3001\u76ae\u819a\u306e\u52d5\u304d\u304c\u5c11\u306a\u3044\u982d\u76ae\u3084\u524d\u811b\u9aa8\u90e8\u306a\u3069\u3067\u306f\u3001\u30b1\u30ed\u30a4\u30c9\u306e\u767a\u75c7\u306f\u307e\u308c\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u7dca\u5f35\u306e\u65b9\u5411\u306b\u5fdc\u3058\u3066\u3001\u80f8\u90e8\u3067\u306f\u300c\u30ab\u30cb\u306e\u306f\u3055\u307f\u72b6\uff08crab\u2019s claw\uff09\u300d\u3001\u80a9\u3067\u306f\u300c\u30c0\u30f3\u30d9\u30eb\u72b6\uff08dumbbell\uff09\u300d\u306a\u3069\u3001\u7279\u6709\u306e\u5f62\u614b\u3092\u53d6\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32045624_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4628\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32045624_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32045624_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u6cbb\u7642\u6cd5\u306e\u9078\u629e\u80a2<\/h2>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306e\u6cbb\u7642\u306f\u518d\u767a\u7387\u304c\u9ad8\u304f\u3001\u5358\u72ec\u7642\u6cd5\u3067\u306e\u5b8c\u6cbb\u306f\u96e3\u3057\u3044\u305f\u3081\u3001\u8907\u6570\u306e\u6cbb\u7642\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u500b\u5225\u5316\u6226\u7565\u304c\u57fa\u672c\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32081679_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4629\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32081679_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32081679_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u7b2c\u4e00\u9078\u629e\u6cbb\u7642<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">\u526f\u814e\u76ae\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9\uff08Corticosteroids\uff09<\/h4>\n\n\n\n<p>\u30c8\u30ea\u30a2\u30e0\u30b7\u30ce\u30ed\u30f3\uff08triamcinolone\uff09\u306a\u3069\u306e\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u75c5\u5909\u5185\u306b\u6ce8\u5c04\u3059\u308b\u6cbb\u7642\u304c\u7b2c\u4e00\u9078\u629e\u3068\u3055\u308c\u30014\u301c6\u9031\u9593\u9593\u9694\u3067\u884c\u3044\u307e\u3059\u3002\u5916\u7528\u85ac\u3084\u30b9\u30c6\u30ed\u30a4\u30c9\u542b\u6709\u30c6\u30fc\u30d7\uff08\u4f8b\uff1a\u30c9\u30ec\u30cb\u30be\u30f3\u30c6\u30fc\u30d7\uff09\u3082\u75c7\u72b6\u7de9\u548c\u306b\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u51cd\u7d50\u7642\u6cd5\uff08Cryotherapy\uff09<\/h4>\n\n\n\n<p>\u6db2\u4f53\u7a92\u7d20\u306a\u3069\u3092\u7528\u3044\u3066\u3001\u30b1\u30ed\u30a4\u30c9\u7d44\u7e54\u3092\u51cd\u7d50\u30fb\u878d\u89e3\u3055\u305b\u308b\u3053\u3068\u3067\u7d30\u80de\u58ca\u6b7b\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u8272\u7d20\u6c88\u7740\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u8272\u306e\u6fc3\u3044\u808c\u3067\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u30b7\u30ea\u30b3\u30f3\u30b7\u30fc\u30c8\u30fb\u5727\u8feb\u7642\u6cd5\uff08Compression therapy\uff09<\/h4>\n\n\n\n<p>\u30b7\u30ea\u30b3\u30f3\u30b2\u30eb\u30b7\u30fc\u30c8\u306a\u3069\u3067\u4e00\u5b9a\u306e\u5727\u529b\uff0815\u301c45 mmHg\uff09\u3092\u304b\u3051\u30011\u65e523\u6642\u9593\u4ee5\u4e0a\u3001\u6700\u4f4e6\u30f6\u6708\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u518d\u767a\u4e88\u9632\u306b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32130373_s.jpg\" alt=\"\u5973\u6027\u9854\" class=\"wp-image-4630\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32130373_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32130373_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u624b\u8853\u3068\u9ad8\u5ea6\u6cbb\u7642<\/h3>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">\u5207\u9664\u8853\u3068\u653e\u5c04\u7dda\u7642\u6cd5<\/h4>\n\n\n\n<p>\u7f8e\u5bb9\u7684\u307e\u305f\u306f\u6a5f\u80fd\u7684\u306a\u7406\u7531\u3067\u624b\u8853\u304c\u9078\u629e\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u5207\u9664\u5358\u72ec\u3067\u306f45\u301c100%\u306e\u518d\u767a\u7387\u304c\u3042\u308b\u305f\u3081\u3001\u8853\u5f8c\u306b\u30b9\u30c6\u30ed\u30a4\u30c9\u6ce8\u5c04\u3084\u653e\u5c04\u7dda\u6cbb\u7642\uff08\u8853\u5f8c24\u301c28\u6642\u9593\u4ee5\u5185\uff09\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u300218\u6b73\u672a\u6e80\u3084\u611f\u53d7\u6027\u306e\u9ad8\u3044\u90e8\u4f4d\u3067\u306f\u653e\u5c04\u7dda\u306e\u4f7f\u7528\u306b\u306f\u614e\u91cd\u3092\u8981\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u30ec\u30fc\u30b6\u30fc\u6cbb\u7642\uff08Laser therapy\uff09<\/h4>\n\n\n\n<p>585nm\u30d1\u30eb\u30b9\u30c0\u30a4\u30ec\u30fc\u30b6\u30fc\u30841065nm Nd:YAG\u30ec\u30fc\u30b6\u30fc\u306f\u3001\u8907\u6570\u56de\u306e\u7167\u5c04\u3067\u30b1\u30ed\u30a4\u30c9\u306e\u539a\u307f\u3084\u8d64\u307f\u3092\u8efd\u6e1b\u3059\u308b\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u305d\u306e\u4ed6\u306e\u85ac\u7269\u7642\u6cd5<\/h4>\n\n\n\n<p>\u30dc\u30c4\u30ea\u30cc\u30b9\u30c8\u30ad\u30b7\u30f3\uff08botulinum toxin\uff09\u3001\u30d6\u30ec\u30aa\u30de\u30a4\u30b7\u30f3\uff08bleomycin\uff09\u30015-\u30d5\u30eb\u30aa\u30ed\u30a6\u30e9\u30b7\u30eb\uff085-fluorouracil\uff09\u3001\u30a4\u30df\u30ad\u30e2\u30c9\uff08imiquimod\uff09\u306a\u3069\u304c\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u5358\u72ec\u307e\u305f\u306f\u4f75\u7528\u3067\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/31975546_s.jpg\" alt=\"\u3058\u3087\u305b\u3044\u304b\u304a\" class=\"wp-image-4631\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31975546_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31975546_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u624b\u8853\u524d\u5f8c\u306e\u30b1\u30a2\u3068\u6ce8\u610f\u70b9<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u8853\u524d\u30fb\u8853\u5f8c\u306e\u6ce8\u610f\u4e8b\u9805<\/h3>\n\n\n\n<p>\u9ad8\u8840\u5727\u6cbb\u7642\u85ac\u3084\u6297\u51dd\u56fa\u85ac\u3092\u670d\u7528\u4e2d\u306e\u65b9\u3001\u9ebb\u9154\u6b74\u306b\u554f\u984c\u304c\u3042\u308b\u65b9\u306f\u4e8b\u524d\u306b\u7533\u544a\u304c\u5fc5\u8981\u3067\u3059\u3002\u8853\u5f8c\u306b\u306f\u6297\u751f\u7269\u8cea3\u65e5\u5206\u3068\u93ae\u75db\u85ac\u304c\u51e6\u65b9\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5275\u90e8\u7ba1\u7406<\/h3>\n\n\n\n<p>\u8853\u7fcc\u65e5\u306b\u518d\u8a3a\u304c\u884c\u308f\u308c\u3001\u554f\u984c\u304c\u306a\u3051\u308c\u3070\u5165\u6d74\u30fb\u6d17\u6d44\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4ee5\u964d\u306f\u6bce\u65e5\u5165\u6d74\u5f8c\u306b\u5275\u90e8\u3092\u6d88\u6bd2\u3057\u3001\u51e6\u65b9\u3055\u308c\u305f\u8edf\u818f\u3092\u5857\u5e03\u3057\u3066\u30ac\u30fc\u30bc\u3067\u4fdd\u8b77\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u629c\u7cf8\u5f8c\u306e\u30b1\u30a2<\/h3>\n\n\n\n<p>\u50b7\u8de1\u3092\u5e73\u3089\u306b\u6574\u3048\u308b\u305f\u3081\u3001\u7d041\u30f6\u6708\u9593\u306f\u8336\u8272\u306e\u533b\u7642\u7528\u30c6\u30fc\u30d7\u3067\u4fdd\u8b77\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u8d64\u307f\u6291\u5236\u306e\u8edf\u818f\u3092\u5857\u5e03\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32110244_s.jpg\" alt=\"\u3058\u3087\u305b\u3044\u304b\u304a\" class=\"wp-image-4632\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32110244_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32110244_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u6700\u65b0\u7814\u7a76\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u5b9f\u9a13\u30e2\u30c7\u30eb\u3068\u30d1\u30e9\u30c0\u30a4\u30e0\u30b7\u30d5\u30c8<\/h3>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306f\u30d2\u30c8\u7279\u6709\u306e\u75be\u60a3\u3067\u3042\u308b\u305f\u3081\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u5b8c\u5168\u306a\u518d\u73fe\u304c\u56f0\u96e3\u3067\u3059\u3002\u8fd1\u5e74\u3067\u306f\u3001\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\uff08keratinocytes\uff09\u3068\u7dda\u7dad\u82bd\u7d30\u80de\u3092\u5171\u57f9\u990a\u3059\u308b3\u6b21\u5143\u30e2\u30c7\u30eb\uff083D organotypic co-culture\uff09\u304c\u6ce8\u76ee\u3055\u308c\u3001\u3088\u308a\u5b9f\u969b\u306e\u75c5\u614b\u306b\u8fd1\u3044\u518d\u73fe\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b1\u30ed\u30a4\u30c9\u306e\u518d\u5b9a\u7fa9<\/h3>\n\n\n\n<p>\u56fd\u969b\u75be\u75c5\u5206\u985e\u7b2c11\u7248\uff08ICD-11\uff09\u3067\u306f\u3001\u30b1\u30ed\u30a4\u30c9\u304c\u7dda\u7dad\u816b\u75c7\uff08fibromatosis\uff09\u306b\u5206\u985e\u3055\u308c\u3001\u5358\u306a\u308b\u7f8e\u5bb9\u7684\u554f\u984c\u3067\u306f\u306a\u304f\u3001\u816b\u760d\u69d8\u306e\u7dda\u7dad\u5897\u6b96\u75be\u60a3\u3068\u898b\u306a\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u8996\u70b9\u306e\u8ee2\u63db\u306f\u3001\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u7cbe\u5ea6\u3092\u9ad8\u3081\u308b\u3046\u3048\u3067\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/31944915_s.jpg\" alt=\"\u3058\u3087\u305b\u3044\u304b\u304a\" class=\"wp-image-4633\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31944915_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/31944915_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6<\/h2>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9\u306f\u5358\u306a\u308b\u76ae\u819a\u306e\u7622\u75d5\u3067\u306f\u306a\u304f\u3001\u8907\u96d1\u306a\u7dda\u7dad\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u907a\u4f1d\u3001\u74b0\u5883\u3001\u30db\u30eb\u30e2\u30f3\u3001\u6a5f\u68b0\u7684\u523a\u6fc0\u3068\u3044\u3063\u305f\u591a\u69d8\u306a\u56e0\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u884c\u306e\u6cbb\u7642\u6cd5\u306f\u591a\u304f\u5b58\u5728\u3059\u308b\u3082\u306e\u306e\u3001\u5b8c\u6cbb\u306f\u96e3\u3057\u304f\u3001\u518d\u767a\u306e\u53ef\u80fd\u6027\u3082\u9ad8\u3044\u305f\u3081\u3001\u4e88\u9632\u3068\u65e9\u671f\u5bfe\u5fdc\u304c\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u3059\u3079\u3066\u306e\u533b\u7642\u5f93\u4e8b\u8005\u306f\u3001\u30b1\u30ed\u30a4\u30c9\u306b\u5bfe\u3059\u308b\u6df1\u3044\u7406\u89e3\u3068\u614e\u91cd\u306a\u5bfe\u5fdc\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u4eca\u5f8c\u306f\u3001\u6a5f\u68b0\u7684\u523a\u6fc0\u3084\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u304a\u308a\u3001\u5275\u50b7\u6cbb\u7652\u306e\u7406\u89e3\u304c\u3055\u3089\u306a\u308b\u98db\u8e8d\u3092\u9042\u3052\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32045632_s.jpg\" alt=\"\u3058\u3087\u305b\u3044\u304b\u304a\" class=\"wp-image-4634\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32045632_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32045632_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9<\/h2>\n\n\n\n<p>\u30b1\u30ed\u30a4\u30c9, \u80a5\u539a\u6027\u7622\u75d5, \u50b7\u3042\u3068, \u7622\u75d5, \u3057\u3053\u308a, \u76db\u308a\u4e0a\u304c\u3063\u305f\u50b7, \u76ae\u819a\u79d1, \u5f62\u6210\u5916\u79d1, \u30b1\u30ed\u30a4\u30c9\u4f53\u8cea, \u5275\u50b7\u6cbb\u7652, \u30b7\u30ea\u30b3\u30f3\u30b7\u30fc\u30c8, \u30b9\u30c6\u30ed\u30a4\u30c9\u6ce8\u5c04, \u30b1\u30ed\u30a4\u30c9\u6cbb\u7642, \u50b7\u3042\u3068\u30b1\u30a2, \u653e\u5c04\u7dda\u7642\u6cd5, \u5727\u8feb\u7642\u6cd5, \u30b3\u30e9\u30fc\u30b2\u30f3, \u7dda\u7dad\u82bd\u7d30\u80de, \u76ae\u819a\u30c8\u30e9\u30d6\u30eb, \u708e\u75c7, \u76ae\u819a\u306e\u304b\u3086\u307f, \u76ae\u819a\u306e\u518d\u751f<\/p>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/dermatology\/wp-content\/uploads\/2025\/03\/32158668_s.jpg\" alt=\"\u3058\u3087\u305b\u3044\u304b\u304a\" class=\"wp-image-4635\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32158668_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/03\/32158668_s-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/course\/keloid\/\"><em>\u5ddd\u53e3\u5e02\u306e\u5f62\u6210\u5916\u79d1\u30fb\u76ae\u819a\u79d1\u306f\u5ddd\u53e3\u99c5\u304b\u3089\u5f92\u6b693\u5206\u306e\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\uff5c\u76ae\u819a\u79d1\u30fb\u5f62\u6210\u5916\u79d1\u306e\u5c02\u9580\u6cbb\u7642\u306a\u3089\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af<\/em>. (2021\u5e747\u670813\u65e5). Retrieved 28 March 2025, from https:\/\/www.hiro-clinic.or.jp\/dermatology\/course\/keloid\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507899\/\">McGinty S, Siddiqui WJ. Keloid. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507899\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fcell.2020.00360\">Limandjaja, G. C., Niessen, F. B., Scheper, R. J., &amp; Gibbs, S. (2020). The keloid disorder: Heterogeneity, histopathology, mechanisms and models. <em>Frontiers in Cell and Developmental Biology<\/em>, <em>8<\/em>, 360. https:\/\/doi.org\/10.3389\/fcell.2020.00360<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1177\/2059513119868659\">Tsai, C.-H., &amp; Ogawa, R. (2019). Keloid research: Current status and future directions. <em>Scars, Burns &amp; Healing<\/em>, <em>5<\/em>, 2059513119868659. https:\/\/doi.org\/10.1177\/2059513119868659<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><figure><a href=\"\/dermatology\/access\/\"><br \/>\n<img decoding=\"async\" src=\"\/dermatology\/wp-content\/uploads\/2025\/04\/cta-pattern1.webp\" alt=\"\u8eab\u8fd1\u306a\u76ae\u819a\u306e\u60a9\u307f\u3001\u5c02\u9580\u533b\u306b\u6c17\u8efd\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u30af\u30ea\u30cb\u30c3\u30af\u306f\u3053\u3061\u3089\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\u30b1\u30ed\u30a4\u30c9\u3068\u80a5\u539a\u6027\u7622\u75d5\u306e\u7406\u89e3 \u30b1\u30ed\u30a4\u30c9\uff08Keloid\uff09\u3068\u80a5\u539a\u6027\u7622\u75d5\uff08Hypertrophic scar\uff09\u306f\u3001\u3044\u305a\u308c\u3082\u5275\u50b7\u6cbb\u7652\uff08wound healing\uff09\u306e\u7570\u5e38\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u76ae\u819a\u306e\u7dda\u7dad\u5897\u6b96\u6027\u75be\u60a3\uff08fibroprolifer [&hellip;]","protected":false},"author":44,"featured_media":4620,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[230,229,237,236,110,243,241,232,233,235,245,207,239,238,231,244,242,240,39,227,234,228],"class_list":["post-4616","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-derma","tag-230","tag-229","tag-237","tag-236","tag-110","tag-243","tag-241","tag-232","tag-233","tag-235","tag-245","tag-207","tag-239","tag-238","tag-231","tag-244","tag-242","tag-240","tag-39","tag-227","tag-234","tag-228"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/posts\/4616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/users\/44"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/comments?post=4616"}],"version-history":[{"count":5,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/posts\/4616\/revisions"}],"predecessor-version":[{"id":4694,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/posts\/4616\/revisions\/4694"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/media\/4620"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/media?parent=4616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/categories?post=4616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-json\/wp\/v2\/tags?post=4616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}