{"id":5246,"date":"2025-09-01T17:04:11","date_gmt":"2025-09-01T08:04:11","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/?p=5246"},"modified":"2025-09-01T17:04:11","modified_gmt":"2025-09-01T08:04:11","slug":"melanoma-stages-treatment","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/dermatology\/derma\/dermatology-basics\/skin-disease-guide\/melanoma-stages-treatment\/","title":{"rendered":"\u60aa\u6027\u9ed2\u8272\u816b\u306e\u9032\u884c\u5ea6\u3068\u6cbb\u7642\u6cd5"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>\u60aa\u6027\u9ed2\u8272\u816b\uff08\u30e1\u30e9\u30ce\u30fc\u30de\uff09\u306f\u76ae\u819a\u304c\u3093\u306e\u4e2d\u3067\u3082\u7279\u306b\u9032\u884c\u304c\u901f\u304f\u3001\u653e\u7f6e\u3059\u308b\u3068\u751f\u547d\u306b\u3082\u95a2\u308f\u308b\u6df1\u523b\u306a\u75be\u60a3\u3067\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u4e16\u754c\u6a19\u6e96\u3067\u7528\u3044\u3089\u308c\u308b\u9032\u884c\u5ea6\u5206\u985e\uff08\u30b9\u30c6\u30fc\u30b8\u5206\u985e\uff09\u3092\u4e01\u5be7\u306b\u89e3\u8aac\u3057\u3001\u305d\u308c\u305e\u308c\u306e\u30b9\u30c6\u30fc\u30b8\u306b\u304a\u3051\u308b\u6700\u9069\u306a\u6cbb\u7642\u6cd5\uff08\u624b\u8853\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u3001\u5206\u5b50\u6a19\u7684\u7642\u6cd5\u306a\u3069\uff09\u3092\u7db2\u7f85\u7684\u306b\u7d39\u4ecb\u3057\u307e\u3059\u3002\u65e9\u671f\u767a\u898b\u306e\u305f\u3081\u306e\u30d2\u30f3\u30c8\u3084\u3001\u6700\u65b0\u306e\u6cbb\u7642\u30c8\u30ec\u30f3\u30c9\u306b\u3082\u89e6\u308c\u3001\u533b\u7642\u5f93\u4e8b\u8005\u304a\u3088\u3073\u60a3\u8005\u3055\u3093\u53cc\u65b9\u306b\u3068\u3063\u3066\u8aad\u307f\u5fdc\u3048\u306e\u3042\u308b\u5185\u5bb9\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002<br><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u60aa\u6027\u9ed2\u8272\u816b\u3068\u306f\uff1a\u75ab\u5b66\u3068\u75c5\u614b<\/strong><\/h2>\n\n\n\n<p>\u60aa\u6027\u9ed2\u8272\u816b\u306f\u3001\u76ae\u819a\u306e\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\uff08\u8272\u7d20\u7d30\u80de\uff09\u304b\u3089\u767a\u751f\u3059\u308b\u304c\u3093\u3067\u3042\u308a\u3001\u76ae\u819a\u304c\u3093\u306e\u4e2d\u3067\u306f\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\u3067\u3059\u3002\u7279\u306b\u767d\u4eba\u306b\u591a\u304f\u898b\u3089\u308c\u307e\u3059\u304c\u3001\u65e5\u672c\u3067\u3082\u5897\u52a0\u50be\u5411\u306b\u3042\u308a\u307e\u3059\u3002\u65e5\u672c\u76ae\u819a\u79d1\u5b66\u4f1a\u306b\u3088\u308c\u3070\u3001\u8fd1\u5e74\u306e\u56fd\u5185\u767b\u9332\u4f8b\u3067\u3082\u5897\u52a0\u50be\u5411\u304c\u7d9a\u3044\u3066\u304a\u308a\u3001\u9ad8\u9f62\u8005\u3084\u7d2b\u5916\u7dda\u66b4\u9732\u306e\u591a\u3044\u4eba\u306b\u767a\u75c7\u304c\u591a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u75c5\u614b\u3068\u3057\u3066\u306f\u3001\u6591\u70b9\u72b6\u306e\u8272\u7d20\u75c5\u5909\u304c\u5f90\u3005\u306b\u30bf\u30c6\u65b9\u5411\u3042\u308b\u3044\u306f\u30e8\u30b3\u65b9\u5411\u306b\u6d78\u6f64\u3057\u3001\u30ea\u30f3\u30d1\u7bc0\u3084\u9060\u9694\u81d3\u5668\uff08\u80ba\u3001\u809d\u81d3\u3001\u8133\u306a\u3069\uff09\u3078\u8ee2\u79fb\u3059\u308b\u305f\u3081\u3001\u65e9\u671f\u767a\u898b\u30fb\u6cbb\u7642\u304c\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u9032\u884c\u5ea6\uff08\u30b9\u30c6\u30fc\u30b8\u5206\u985e\uff09\u306e\u7406\u89e3<\/strong><\/h2>\n\n\n\n<p>\u60aa\u6027\u9ed2\u8272\u816b\u306e\u9032\u884c\u5ea6\u306f\u3001\u4e00\u822c\u7684\u306bTNM\u5206\u985e\u306b\u57fa\u3065\u304d\u30b9\u30c6\u30fc\u30b80\u304b\u3089IV\u307e\u3067\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b9\u30c6\u30fc\u30b80\uff08in situ\uff09<\/strong><strong><br><\/strong> \u3000\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304c\u8868\u76ae\u5185\u306b\u3068\u3069\u307e\u3063\u3066\u3044\u308b\u72b6\u614b\u3067\u3001\u6975\u3081\u3066\u65e9\u671f\u3002\u8ee2\u79fb\u306f\u306a\u3044\u3002<br><\/li>\n\n\n\n<li><strong>\u30b9\u30c6\u30fc\u30b8I\u2013II\uff08\u5c40\u6240\u9032\u884c\uff09<\/strong><strong><br><\/strong> \u3000\u816b\u760d\u539a\uff08Breslow\u539a\uff09\u3068\u76ae\u819a\u8868\u9762\u306e\u6f70\u760d\u306e\u6709\u7121\u306b\u3088\u308a\u7d30\u304b\u304f\u5206\u985e\u3055\u308c\u307e\u3059\u3002I\u671f\u3067\u306f\u6d45\u3044\u539a\u3055\u3001II\u671f\u3067\u306f\u3088\u308a\u539a\u304f\u6f70\u760d\u5f62\u6210\u3092\u4f34\u3046\u3082\u306e\u304c\u542b\u307e\u308c\u3001\u3044\u305a\u308c\u3082\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\u306b\u306f\u81f3\u3063\u3066\u3044\u306a\u3044\u3082\u306e\u306e\u3001\u518d\u767a\u30ea\u30b9\u30af\u304c\u5897\u3057\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u30b9\u30c6\u30fc\u30b8III\uff08\u9818\u57df\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\uff09<\/strong><strong><br><\/strong> \u3000\u8fd1\u96a3\u306e\u30ea\u30f3\u30d1\u7bc0\u307e\u305f\u306f\u30ea\u30f3\u30d1\u7ba1\u3078\u306e\u8ee2\u79fb\u304c\u8a8d\u3081\u3089\u308c\u308b\u6bb5\u968e\u3067\u3059\u3002\u518d\u767a\u7387\u304c\u4e0a\u304c\u308a\u3001\u5168\u8eab\u6cbb\u7642\u306e\u4f75\u7528\u304c\u691c\u8a0e\u3055\u308c\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u30b9\u30c6\u30fc\u30b8IV\uff08\u9060\u9694\u8ee2\u79fb\uff09<\/strong><strong><br><\/strong> \u3000\u9060\u9694\u81d3\u5668\u3078\u306e\u8ee2\u79fb\u304c\u3042\u308b\u72b6\u614b\u3067\u3001\u6a19\u6e96\u7684\u306b\u5168\u8eab\u6cbb\u7642\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u6cbb\u7642\u306e\u30b4\u30fc\u30eb\u306f\u5ef6\u547d\u304a\u3088\u3073\u751f\u6d3b\u306e\u8cea\u306e\u7dad\u6301\u3067\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u30b9\u30c6\u30fc\u30b8\u5225\u306e\u6cbb\u7642\u6226\u7565<\/strong><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b9\u30c6\u30fc\u30b80\uff08in situ\uff09<\/strong><\/h4>\n\n\n\n<p>\u6700\u3082\u6cbb\u7642\u3057\u3084\u3059\u3044\u6bb5\u968e\u3067\u3042\u308a\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u304c\u8868\u76ae\u306b\u9650\u5c40\u3057\u3066\u3044\u308b\u305f\u3081\u3001<strong>\u5916\u79d1\u7684\u5207\u9664<\/strong>\u306b\u3088\u308a\u6cbb\u7652\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u9069\u5207\u306a\u30de\u30fc\u30b8\u30f3\uff08\u5916\u79d1\u7684\u5b89\u5168\u57df\uff09\u3092\u542b\u3081\u305f\u5207\u9664\u304c\u539f\u5247\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b9\u30c6\u30fc\u30b8I\u2013II\uff1a\u5c40\u6240\u9032\u884c\u671f<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5916\u79d1\u5207\u9664<\/strong>\uff1a\u5c40\u6240\u816b\u760d\u3092\u5341\u5206\u30de\u30fc\u30b8\u30f3\u3092\u3068\u3063\u3066\u5207\u9664\u3002<br><\/li>\n\n\n\n<li><strong>\u30bb\u30f3\u30c1\u30cd\u30eb\u30ea\u30f3\u30d1\u7bc0\u751f\u691c\uff08SLNB\uff09<\/strong>\uff1a\u816b\u760d\u304c\u539a\u304f\u306a\u308b\u307b\u3069\u3001\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308a\u3001SLNB\u306b\u3088\u308a\u8ee2\u79fb\u3092\u78ba\u8a8d\u30fb\u4e88\u6e2c\u3057\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u88dc\u52a9\u7642\u6cd5<\/strong>\uff1a\u9ad8\u30ea\u30b9\u30af\uff08Breslow\u539a\u304c\u539a\u3044\u3001\u6f70\u760d\u3042\u308a\u306a\u3069\uff09\u3067\u306f\u3001\u8853\u5f8c\u306b<strong>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264<\/strong>\uff08\u4f8b\uff1a\u30cb\u30dc\u30eb\u30de\u30d6\u3001\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\uff09\u306b\u3088\u308b\u88dc\u52a9\u7642\u6cd5\u3092\u691c\u8a0e\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u518d\u767a\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b9\u30c6\u30fc\u30b8III\uff1a\u9818\u57df\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5916\u79d1\u624b\u8853<\/strong>\uff1a\u539f\u767a\u5de3\u306b\u52a0\u3048\u3066\u8ee2\u79fb\u30ea\u30f3\u30d1\u7bc0\u3092\u542b\u3081\u305f\u5e83\u7bc4\u5207\u9664\u304c\u57fa\u672c\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u88dc\u52a9\u7642\u6cd5<\/strong>\uff1a\u30cb\u30dc\u30eb\u30de\u30d6\u307e\u305f\u306f\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u306a\u3069\u3001<strong>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264<\/strong>\u306b\u3088\u308b\u6cbb\u7642\u306b\u52a0\u3048\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f<strong>BRAF\/MEK\u963b\u5bb3\u5264<\/strong>\uff08BRAF\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u5834\u5408\uff09\u3092\u4f7f\u7528\u3002<br><\/li>\n\n\n\n<li><strong>\u653e\u5c04\u7dda\u7642\u6cd5<\/strong>\uff1a\u518d\u767a\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u9818\u57df\u306b\u5bfe\u3057\u3066\u306f\u88dc\u52a9\u7684\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b9\u30c6\u30fc\u30b8IV\uff1a\u9060\u9694\u8ee2\u79fb\u671f<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u514d\u75ab\u7642\u6cd5<\/strong>\uff1a\u30cb\u30dc\u30eb\u30de\u30d6\uff0b\u30a4\u30d4\u30ea\u30e0\u30de\u30d6\u4f75\u7528\u304c\u9ad8\u3044\u594f\u52b9\u7387\u3092\u793a\u3059\u75c7\u4f8b\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u526f\u4f5c\u7528\u7ba1\u7406\u304c\u91cd\u8981\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u5206\u5b50\u6a19\u7684\u7642\u6cd5<\/strong>\uff1aBRAF V600\u5909\u7570\u967d\u6027\u4f8b\u3067\u306f\u3001<strong>BRAF\u963b\u5bb3\u5264\uff0bMEK\u963b\u5bb3\u5264<\/strong>\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\uff08\u4f8b\uff1a\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\uff0b\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u306a\u3069\uff09\u304c\u52b9\u679c\u7684\u3002<br><\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6\u6cbb\u7642<\/strong>\uff1a\u75c7\u72b6\u7de9\u548c\u3084\u751f\u6d3b\u306e\u8cea\u7dad\u6301\u306e\u305f\u3081\u3001<strong>\u653e\u5c04\u7dda\u7642\u6cd5<\/strong>\u3084<strong>\u5316\u5b66\u7642\u6cd5<\/strong>\uff08\u30c0\u30ab\u30eb\u30d0\u30b8\u30f3\u306a\u3069\uff09\u3082\u9650\u5b9a\u7684\u306b\u4f75\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u6700\u8fd1\u3067\u306f<strong>\u816b\u760d\u30ef\u30af\u30c1\u30f3\u7642\u6cd5<\/strong>\u3084<strong>CAR-T\u7642\u6cd5<\/strong>\u306a\u3069\u3001\u81e8\u5e8a\u8a66\u9a13\u3067\u306e\u5831\u544a\u3082\u5897\u3048\u3066\u3044\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u6cbb\u7642\u9078\u629e\u306e\u30dd\u30a4\u30f3\u30c8\u3068\u6700\u65b0\u52d5\u5411<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BRAF\u907a\u4f1d\u5b50\u5909\u7570\u306e\u6709\u7121\u306e\u691c\u67fb<\/strong>\uff1a\u6cbb\u7642\u6cd5\u9078\u629e\u306b\u304a\u3044\u3066\u6975\u3081\u3066\u91cd\u8981\u3002\u907a\u4f1d\u5b50\u5909\u7570\u967d\u6027\u3067\u3042\u308c\u3070\u3001\u5206\u5b50\u6a19\u7684\u7642\u6cd5\u304c\u9078\u629e\u80a2\u306b\u3002<br><\/li>\n\n\n\n<li><strong>\u514d\u75ab\u7642\u6cd5\u306e\u9032\u5316<\/strong>\uff1a\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306f\u6cbb\u7642\u306e\u6839\u5e79\u3092\u62c5\u3044\u3064\u3064\u3001\u526f\u4f5c\u7528\uff08\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\uff09\u3078\u306e\u6ce8\u610f\u304c\u5fc5\u9808\u3002<br><\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u533b\u7642<\/strong>\uff1a\u816b\u760d\u30de\u30fc\u30ab\u30fc\u3084\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u6700\u9069\u306a\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b\u6642\u4ee3\u306b\u3002<br><\/li>\n\n\n\n<li><strong>\u81e8\u5e8a\u8a66\u9a13\u306e\u5897\u52a0<\/strong>\uff1a\u65b0\u898f\u6297\u4f53\u3001\u30ef\u30af\u30c1\u30f3\u3001\u7d30\u80de\u6cbb\u7642\u306a\u3069\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u6d3b\u767a\u5316\u3057\u3066\u304a\u308a\u3001\u6a19\u6e96\u6cbb\u7642\u4ee5\u5916\u306e\u6700\u524d\u7dda\u306b\u3082\u30a2\u30af\u30bb\u30b9\u3067\u304d\u308b\u6a5f\u4f1a\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u65e9\u671f\u767a\u898b\u3068\u4e88\u9632\u306e\u91cd\u8981\u6027<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u81ea\u5df1\u691c\u8a3a<\/strong>\uff1aABCDE\uff08Asymmetry\uff1a\u975e\u5bfe\u79f0\u6027\u3001Border\uff1a\u3075\u3061\u306e\u4e0d\u6574\u3001Color\uff1a\u8272\u8abf\u4e0d\u5747\u4e00\u3001Diameter\uff1a\u76f4\u5f846 mm\u4ee5\u4e0a\u3001Evolving\uff1a\u5f62\u72b6\u30fb\u5927\u304d\u3055\u306e\u5909\u5316\uff09\u3092\u610f\u8b58\u3057\u305f\u76ae\u819a\u30c1\u30a7\u30c3\u30af\u3092\u5b9a\u671f\u7684\u306b\u884c\u3046\u3053\u3068\u3002<br><\/li>\n\n\n\n<li><strong>\u76ae\u819a\u79d1\u53d7\u8a3a<\/strong>\uff1a\u6c17\u306b\u306a\u308b\u307b\u304f\u308d\u3084\u8272\u7d20\u6591\u304c\u3042\u308c\u3070\u3001\u65e9\u3081\u306e\u76ae\u819a\u79d1\u53d7\u8a3a\u3092\u63a8\u5968\u3002\u30c0\u30fc\u30e2\u30b9\u30b3\u30d4\u30fc\uff08\u76ae\u819a\u9855\u5fae\u93e1\uff09\u306a\u3069\u306e\u7cbe\u5bc6\u691c\u67fb\u304c\u52b9\u679c\u3002<br><\/li>\n\n\n\n<li><strong>\u7d2b\u5916\u7dda\u5bfe\u7b56<\/strong>\uff1aUV\u2011A\uff0fUV\u2011B\u306e\u4e21\u65b9\u306b\u5bfe\u3059\u308b\u65e5\u713c\u3051\u6b62\u3081\u3001\u5e3d\u5b50\u3001\u9577\u8896\u8863\u985e\u306a\u3069\u3067\u306e\u4e88\u9632\u304c\u6709\u52b9\u3002\u7279\u306b\u5e74\u9593\u901a\u3058\u3066\u306e\u5bfe\u7b56\u304c\u671b\u307e\u3057\u3044\u3002<br><\/li>\n\n\n\n<li><strong>\u5b9a\u671f\u30d5\u30a9\u30ed\u30fc<\/strong>\uff1a\u30b9\u30c6\u30fc\u30b8I\u2013II\u4ee5\u964d\u306f\u518d\u767a\u30fb\u8ee2\u79fb\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u3068\u3057\u3066\u5b9a\u671f\u7684\u306a\u753b\u50cf\u691c\u67fb\uff08CT\u3001PET\u2011CT\u306a\u3069\uff09\u3084\u8840\u6db2\u30de\u30fc\u30ab\u30fc\u6e2c\u5b9a\u306a\u3069\u304c\u91cd\u8981\u3067\u3059\u3002<br><\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"481\" src=\"\/dermatology\/wp-content\/uploads\/2025\/09\/33031158_s.jpg\" alt=\"\u7d2b\u5916\u7dda\u5bfe\u7b56\" class=\"wp-image-5247\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/09\/33031158_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/dermatology\/wp-content\/uploads\/2025\/09\/33031158_s-300x225.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u304a\u308f\u308a\u306b<\/strong><\/h2>\n\n\n\n<p>\u60aa\u6027\u9ed2\u8272\u816b\u306f\u9032\u884c\u6027\u3067\u3042\u308b\u53cd\u9762\u3001\u65e9\u671f\u767a\u898b\u3068\u9069\u5207\u306a\u6cbb\u7642\u306b\u3088\u308a\u9ad8\u3044\u6cbb\u7652\u7387\u304c\u671f\u5f85\u3067\u304d\u308b\u75be\u60a3\u3067\u3059\u3002\u30b9\u30c6\u30fc\u30b8\u5206\u985e\u306b\u5fdc\u3058\u305f\u624b\u8853\u3001\u514d\u75ab\u7642\u6cd5\u3001\u5206\u5b50\u6a19\u7684\u7642\u6cd5\u306a\u3069\u306e\u9078\u629e\u80a2\u3092\u6b63\u3057\u304f\u7406\u89e3\u3057\u3001\u5c02\u9580\u533b\u3068\u5354\u529b\u3057\u3066\u6700\u9069\u306a\u6cbb\u7642\u6226\u7565\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u81ea\u5df1\u691c\u8a3a\u3068\u7d2b\u5916\u7dda\u5bfe\u7b56\u306b\u3088\u308b\u4e88\u9632\u3001\u5b9a\u671f\u7684\u306a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306b\u3088\u308b\u65e9\u671f\u5bfe\u5fdc\u304c\u3001\u751f\u5b58\u7387\u5411\u4e0a\u306b\u76f4\u7d50\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7686\u3055\u307e\u304c\u3053\u306e\u77e5\u8b58\u3092\u6d3b\u304b\u3057\u3001\u3054\u81ea\u8eab\u3084\u3054\u5bb6\u65cf\u306e\u5065\u5eb7\u7ba1\u7406\u306b\u304a\u3044\u3066\u5f79\u7acb\u3066\u3066\u3044\u305f\u3060\u3051\u308c\u3070\u5e78\u3044<strong>7. \u518d\u767a\u30fb\u8ee2\u79fb\u5f8c\u306e\u6cbb\u7642\u6226\u7565\u3068\u4e88\u5f8c\u6539\u5584\u306e\u53d6\u308a\u7d44\u307f<\/strong><\/p>\n\n\n\n<p>\u60aa\u6027\u9ed2\u8272\u816b\u306f\u3001\u521d\u671f\u306b\u9069\u5207\u306a\u6cbb\u7642\u3092\u53d7\u3051\u305f\u3068\u3057\u3066\u3082\u3001\u4e00\u5b9a\u306e\u78ba\u7387\u3067\u518d\u767a\u3084\u8ee2\u79fb\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u30b9\u30c6\u30fc\u30b8II\u4ee5\u964d\u3067\u306f\u5c40\u6240\u518d\u767a\u3084\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\u3001\u3055\u3089\u306b\u9060\u9694\u81d3\u5668\uff08\u80ba\u30fb\u8133\u30fb\u809d\u30fb\u9aa8\u306a\u3069\uff09\u3078\u306e\u8ee2\u79fb\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u518d\u767a\u30fb\u8ee2\u79fb\u6642\u306e\u6cbb\u7642\u6226\u7565\u304a\u3088\u3073\u4e88\u5f8c\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u6700\u65b0\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u518d\u767a\u6642\u306e\u521d\u52d5\u5bfe\u5fdc<\/strong><\/h4>\n\n\n\n<p>\u518d\u767a\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5834\u5408\u3001\u307e\u305a\u884c\u308f\u308c\u308b\u306e\u304c<strong>\u5168\u8eab\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb<\/strong>\u3067\u3059\u3002CT\u3001MRI\u3001PET-CT\u306a\u3069\u3092\u7528\u3044\u3066\u3001\u8ee2\u79fb\u306e\u6709\u7121\u3084\u7bc4\u56f2\u3092\u8fc5\u901f\u304b\u3064\u6b63\u78ba\u306b\u8a55\u4fa1\u3057\u307e\u3059\u3002\u5c40\u6240\u518d\u767a\u3067\u3042\u308c\u3070\u518d\u624b\u8853\u304c\u9069\u5fdc\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u8907\u6570\u8ee2\u79fb\u3084\u9060\u9694\u8ee2\u79fb\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u5168\u8eab\u6cbb\u7642\u306e\u9078\u629e\u304c\u4e2d\u5fc3\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u514d\u75ab\u7642\u6cd5\u306e\u9032\u5316\u3068\u6cbb\u7642\u9078\u629e<\/strong><\/h4>\n\n\n\n<p>\u518d\u767a\u30fb\u8ee2\u79fb\u4f8b\u306b\u304a\u3051\u308b\u7b2c\u4e00\u9078\u629e\u3068\u3057\u3066\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u304c\u5b9a\u7740\u3057\u3066\u3044\u307e\u3059\u3002\u4e2d\u3067\u3082\u3001PD-1\u963b\u5bb3\u5264\uff08\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u3084\u30cb\u30dc\u30eb\u30de\u30d6\uff09\u3068CTLA-4\u963b\u5bb3\u5264\uff08\u30a4\u30d4\u30ea\u30e0\u30de\u30d6\uff09\u306e<strong>\u4f75\u7528\u7642\u6cd5<\/strong>\u306f\u3001\u9ad8\u3044\u594f\u52b9\u7387\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u526f\u4f5c\u7528\uff08\u514d\u75ab\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\uff1airAEs\uff09\u304c\u91cd\u7be4\u5316\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u305f\u3081\u3001\u6295\u4e0e\u5f8c\u306e\u53b3\u5bc6\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3068\u526f\u4f5c\u7528\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u514d\u75ab\u7642\u6cd5\u304c\u52b9\u304b\u306a\u3044\u5834\u5408\u3084\u3001\u8010\u6027\u3092\u7372\u5f97\u3057\u305f\u5834\u5408\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u9078\u629e\u80a2\u3082\u691c\u8a0e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u518d\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u306b\u3088\u308b\u5206\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0<\/strong>\uff1a\u65b0\u305f\u306a\u907a\u4f1d\u5b50\u5909\u7570\u306e\u51fa\u73fe\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u6226\u7565\u3092\u518d\u69cb\u7bc9\u3002<br><\/li>\n\n\n\n<li><strong>\u81e8\u5e8a\u8a66\u9a13\uff08\u6cbb\u9a13\uff09\u3078\u306e\u53c2\u52a0<\/strong>\uff1a\u56fd\u5185\u5916\u3067\u9032\u884c\u4e2d\u306e\u65b0\u85ac\u958b\u767a\u306b\u30a2\u30af\u30bb\u30b9\u53ef\u80fd\u306a\u5834\u5408\u3001\u53c2\u52a0\u304c\u63a8\u5968\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>BRAF\u5909\u7570\u967d\u6027\u4f8b\u306b\u304a\u3051\u308b\u67d4\u8edf\u306a\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h4>\n\n\n\n<p>BRAF 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