{"id":1197,"date":"2025-09-22T08:42:19","date_gmt":"2025-09-22T08:42:19","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/diet\/?p=1197"},"modified":"2025-09-22T08:42:20","modified_gmt":"2025-09-22T08:42:20","slug":"mounjaro-clinical-trials-obesity-treatment","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/diet\/mounjaro-clinical-trials-obesity-treatment\/","title":{"rendered":"\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u81e8\u5e8a\u8a66\u9a13\u7d50\u679c\u304b\u3089\u898b\u308b\u80a5\u6e80\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u306f\u3058\u3081\u306b<\/strong><\/h2>\n\n\n\n<p>\u80a5\u6e80\u306f\u751f\u6d3b\u7fd2\u6163\u75c5\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u7cd6\u5c3f\u75c5\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u4e16\u754c\u7684\u306a\u516c\u8846\u885b\u751f\u554f\u984c\u3067\u3059\u3002\u56fd\u5185\u5916\u3067\u80a5\u6e80\u4eba\u53e3\u306f\u5897\u52a0\u50be\u5411\u306b\u3042\u308a\u3001\u4f53\u91cd\u7ba1\u7406\u3092\u76ee\u7684\u3068\u3057\u305f\u533b\u7642\u4ecb\u5165\u306e\u91cd\u8981\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u80a5\u6e80\u6cbb\u7642\u85ac\u306e\u4e2d\u3067\u3082\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u308b\u306e\u304c\u300c\u30de\u30f3\u30b8\u30e3\u30ed\uff08\u6ce8\uff1a\u5546\u54c1\u540d\uff09\u300d\u3067\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u81e8\u5e8a\u8a66\u9a13\u7d50\u679c\u3092\u4e2d\u5fc3\u306b\u3001\u305d\u306e\u52b9\u679c\u3068\u5b89\u5168\u6027\u3001\u80a5\u6e80\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u306f\u4f55\u304b<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u5206\u985e\u3055\u308c\u308b\u7d4c\u53e3\u6295\u4e0e\u578b\u306e\u80a5\u6e80\u6cbb\u7642\u85ac\u3067\u3059\u3002GLP-1\u306f\u8178\u7ba1\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3001\u98df\u6b32\u6291\u5236\u3084\u80c3\u6392\u51fa\u901f\u5ea6\u306e\u8abf\u6574\u3092\u901a\u3058\u3066\u4f53\u91cd\u6e1b\u5c11\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u5f93\u6765\u306e\u6ce8\u5c04\u578bGLP-1\u85ac\u3068\u6bd4\u3079\u3001\u7d4c\u53e3\u6295\u4e0e\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u670d\u85ac\u306e\u30cf\u30fc\u30c9\u30eb\u304c\u4f4e\u304f\u3001\u65e5\u5e38\u751f\u6d3b\u306b\u53d6\u308a\u5165\u308c\u3084\u3059\u3044\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3051\u308b\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>STEP\u8a66\u9a13\u30b7\u30ea\u30fc\u30ba<\/strong><\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u306f\u3001\u591a\u304f\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u6ce8\u76ee\u3055\u308c\u308b\u306e\u306f\u3001STEP\u8a66\u9a13\u30b7\u30ea\u30fc\u30ba\u3067\u3059\u3002STEP1\u3067\u306f\u3001\u80a5\u6e80\u307e\u305f\u306f\u904e\u4f53\u91cd\u306e\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u3092\u7528\u3044\u305f\u9577\u671f\u6295\u4e0e\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u300152\u9031\u9593\u306e\u6295\u4e0e\u5f8c\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11\u306f8\u301c10\uff05\u3068\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Wilding JPH et al., <em>N Engl J Med<\/em>, 2021\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u60a3\u8005\u3078\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>STEP2\u8a66\u9a13\u3067\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u3092\u6709\u3059\u308b\u80a5\u6e80\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u6295\u4e0e\u7fa4\u306f\u4f53\u91cd\u6e1b\u5c11\u3060\u3051\u3067\u306a\u304fHbA1c\u6539\u5584\u52b9\u679c\u3082\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u80a5\u6e80\u6cbb\u7642\u3060\u3051\u3067\u306a\u304f\u7cd6\u4ee3\u8b1d\u6539\u5584\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9ad8\u7528\u91cf\u6295\u4e0e\u306b\u3088\u308b\u5897\u5f37\u52b9\u679c<\/strong><\/h3>\n\n\n\n<p>\u3055\u3089\u306b\u3001STEP3\u304a\u3088\u3073STEP4\u3067\u306f\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u4ecb\u5165\u3068\u7d44\u307f\u5408\u308f\u305b\u305f\u30de\u30f3\u30b8\u30e3\u30ed\u9ad8\u7528\u91cf\u6295\u4e0e\u306b\u3088\u308a\u3001\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u6700\u592715\uff05\u524d\u5f8c\u306b\u9054\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u98df\u4e8b\u5236\u9650\u3084\u904b\u52d5\u7642\u6cd5\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u76f8\u4e57\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4e3b\u306a\u4f5c\u7528\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u98df\u6b32\u6291\u5236<\/strong><strong><br><\/strong> GLP-1\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3057\u3001\u8996\u5e8a\u4e0b\u90e8\u306e\u6442\u98df\u4e2d\u67a2\u306b\u4fe1\u53f7\u3092\u9001\u308b\u3053\u3068\u3067\u98df\u6b32\u3092\u6291\u5236\u3057\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u80c3\u6392\u51fa\u901f\u5ea6\u306e\u9045\u5ef6<\/strong><strong><br><\/strong> \u80c3\u306e\u6392\u51fa\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u3067\u6e80\u8179\u611f\u3092\u9577\u6642\u9593\u6301\u7d9a\u3055\u305b\u3001\u904e\u98df\u3092\u9632\u304e\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u4fc3\u9032\u3068\u8840\u7cd6\u6539\u5584<\/strong><strong><br><\/strong> \u98df\u4e8b\u6442\u53d6\u5f8c\u306e\u8840\u7cd6\u4e0a\u6607\u306b\u5fdc\u3058\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u3057\u3001\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u6291\u5236\u3057\u307e\u3059\u3002<br><\/li>\n<\/ol>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u4f5c\u7528\u306b\u3088\u308a\u3001\u5358\u306a\u308b\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3067\u306f\u96e3\u3057\u3044\u6301\u7d9a\u7684\u306a\u4f53\u91cd\u6e1b\u5c11\u3092\u9054\u6210\u3067\u304d\u308b\u70b9\u304c\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u5f37\u307f\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5b89\u5168\u6027\u3068\u526f\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<p>\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4e3b\u306a\u526f\u4f5c\u7528\u306f\u3001\u6d88\u5316\u5668\u75c7\u72b6\u304c\u4e2d\u5fc3\u3067\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u5410\u304d\u6c17\u3001\u4e0b\u75e2\u3001\u4fbf\u79d8\u3001\u8179\u90e8\u81a8\u6e80\u611f\u306a\u3069\u3067\u3059\u3002\u591a\u304f\u306f\u6295\u4e0e\u521d\u671f\u306b\u767a\u73fe\u3057\u3001\u6642\u9593\u7d4c\u904e\u3068\u3068\u3082\u306b\u8efd\u6e1b\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u91cd\u5927\u306a\u526f\u4f5c\u7528\u3068\u3057\u3066\u306f\u81b5\u708e\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u767a\u751f\u983b\u5ea6\u306f\u7a00\u3067\u3059\u3002\u307e\u305f\u3001\u5fc3\u8840\u7ba1\u7cfb\u3078\u306e\u6709\u5bb3\u4e8b\u8c61\u306f\u307b\u3068\u3093\u3069\u5831\u544a\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u5b89\u5168\u6027\u306e\u89b3\u70b9\u304b\u3089\u3082\u6bd4\u8f03\u7684\u826f\u597d\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u65e2\u5b58\u306e\u80a5\u6e80\u6cbb\u7642\u85ac\u3068\u306e\u6bd4\u8f03<\/strong><\/h2>\n\n\n\n<p>\u5f93\u6765\u306e\u80a5\u6e80\u6cbb\u7642\u85ac\u306b\u306f\u3001\u30aa\u30eb\u30ea\u30b9\u30bf\u30c3\u30c8\u3084\u30ca\u30eb\u30c8\u30ec\u30ad\u30bd\u30f3\/\u30d6\u30d7\u30ed\u30d4\u30aa\u30f3\u5408\u5264\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u8102\u80aa\u5438\u53ce\u6291\u5236\u3084\u4e2d\u67a2\u795e\u7d4c\u3078\u306e\u4f5c\u7528\u3092\u901a\u3058\u3066\u4f53\u91cd\u6e1b\u5c11\u3092\u4fc3\u3059\u85ac\u5264\u3067\u3059\u304c\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306fGLP-1\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u98df\u6b32\u6291\u5236\u3068\u8840\u7cd6\u6539\u5584\u4f5c\u7528\u3092\u4f75\u305b\u6301\u3064\u70b9\u304c\u7279\u5fb4\u3067\u3059\u3002\u7279\u306b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u4f53\u91cd\u6e1b\u5c11\u306e\u4e21\u65b9\u3092\u540c\u6642\u306b\u9054\u6210\u3067\u304d\u308b\u70b9\u3067\u512a\u4f4d\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u81e8\u5e8a\u5fdc\u7528\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u4e00\u822c\u80a5\u6e80\u60a3\u8005\u3078\u306e\u5fdc\u7528<\/strong><strong><br><\/strong> BMI 30\u4ee5\u4e0a\u3001\u307e\u305f\u306fBMI 27\u4ee5\u4e0a\u3067\u80a5\u6e80\u95a2\u9023\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u6709\u52b9\u306a\u4f53\u91cd\u7ba1\u7406\u624b\u6bb5\u3068\u306a\u308a\u5f97\u307e\u3059\u3002\u7279\u306b\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3060\u3051\u3067\u306f\u52b9\u679c\u304c\u4e0d\u5341\u5206\u306a\u5834\u5408\u306b\u6709\u7528\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u7cd6\u5c3f\u75c5\u60a3\u8005\u3078\u306e\u5fdc\u7528<\/strong><strong><br><\/strong> \u4f53\u91cd\u6e1b\u5c11\u3068\u8840\u7cd6\u6539\u5584\u306e\u4e21\u7acb\u304c\u53ef\u80fd\u306a\u305f\u3081\u3001\u80a5\u6e80\u3092\u4f34\u30462\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3082\u9069\u5fdc\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u8853\u524d\u6e1b\u91cf\u306e\u88dc\u52a9<\/strong><strong><br><\/strong> \u80a5\u6e80\u624b\u8853\u524d\u306e\u6e1b\u91cf\u3084\u5185\u79d1\u7684\u4ecb\u5165\u524d\u306e\u4f53\u91cd\u7ba1\u7406\u3068\u3057\u3066\u3082\u5fdc\u7528\u304c\u8003\u3048\u3089\u308c\u3001\u624b\u8853\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6295\u4e0e\u306e\u5b9f\u969b\u3068\u6ce8\u610f\u70b9<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u7d4c\u53e3\u6295\u4e0e\u304c\u53ef\u80fd\u3067\u3059\u304c\u3001\u670d\u85ac\u6642\u306b\u306f\u98df\u5f8c\u4e00\u5b9a\u6642\u9593\u3092\u7a7a\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b\u306a\u3069\u306e\u6307\u5c0e\u304c\u91cd\u8981\u3067\u3059\u3002\u6d88\u5316\u5668\u75c7\u72b6\u304c\u51fa\u3084\u3059\u3044\u521d\u671f\u6bb5\u968e\u3067\u306f\u3001\u4f4e\u7528\u91cf\u304b\u3089\u6f38\u5897\u3059\u308b\u6295\u4e0e\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u814e\u969c\u5bb3\u3084\u81b5\u75be\u60a3\u306e\u65e2\u5f80\u304c\u3042\u308b\u5834\u5408\u306f\u614e\u91cd\u306a\u6295\u4e0e\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/33435182_s.webp\" alt=\"\u533b\u8005\" class=\"wp-image-1164\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/33435182_s.webp 640w, https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/33435182_s-300x200.webp 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c<\/strong><\/h2>\n\n\n\n<p>\u73fe\u6642\u70b9\u3067\u306f\u9577\u671f\u7684\u306a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u3084\u6b7b\u4ea1\u7387\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u30c7\u30fc\u30bf\u304c\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u65e5\u672c\u4eba\u3092\u542b\u3080\u30a2\u30b8\u30a2\u4eba\u3067\u306e\u6709\u52b9\u6027\u30fb\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u306f\u9650\u5b9a\u7684\u3067\u3042\u308b\u305f\u3081\u3001\u56fd\u5185\u81e8\u5e8a\u7814\u7a76\u306e\u84c4\u7a4d\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u81e8\u5e8a\u52b9\u679c\u3092\u9ad8\u3081\u308b\u751f\u6d3b\u7fd2\u6163\u306e\u5de5\u592b<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u5358\u72ec\u3067\u3082\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u307e\u3059\u304c\u3001\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3055\u3089\u306a\u308b\u6e1b\u91cf\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u4ee5\u4e0b\u306e\u30dd\u30a4\u30f3\u30c8\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u98df\u4e8b\u7ba1\u7406<\/strong><strong><br><\/strong> \u9ad8\u8102\u80aa\u30fb\u9ad8\u7cd6\u8cea\u98df\u54c1\u306e\u6442\u53d6\u3092\u63a7\u3048\u3001\u91ce\u83dc\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u4e2d\u5fc3\u306e\u30d0\u30e9\u30f3\u30b9\u306e\u826f\u3044\u98df\u4e8b\u3092\u5fc3\u639b\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u98df\u6b32\u6291\u5236\u4f5c\u7528\u3092\u6301\u3064\u305f\u3081\u3001\u904e\u98df\u3092\u9632\u3050\u88dc\u52a9\u3068\u3057\u3066\u6709\u52b9\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u5b9a\u671f\u7684\u306a\u904b\u52d5<\/strong><strong><br><\/strong> \u6709\u9178\u7d20\u904b\u52d5\u3084\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u57fa\u790e\u4ee3\u8b1d\u3092\u7dad\u6301\u30fb\u5411\u4e0a\u3055\u305b\u3001\u4f53\u8102\u80aa\u306e\u6e1b\u5c11\u3092\u4fc3\u3057\u307e\u3059\u3002\u81e8\u5e8a\u8a66\u9a13\u3067\u3082\u3001\u904b\u52d5\u3068\u4f75\u7528\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u306f\u3088\u308a\u5927\u304d\u306a\u4f53\u91cd\u6e1b\u5c11\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u7761\u7720\u306e\u8cea\u306e\u6539\u5584<\/strong><strong><br><\/strong> \u7761\u7720\u4e0d\u8db3\u306f\u98df\u6b32\u30db\u30eb\u30e2\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4e71\u3057\u3001\u904e\u98df\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\u5341\u5206\u306a\u7761\u7720\u3092\u78ba\u4fdd\u3059\u308b\u3053\u3068\u3067\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u98df\u6b32\u6291\u5236\u52b9\u679c\u3092\u3088\u308a\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<br><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f7f\u7528\u306b\u95a2\u3059\u308b\u56fd\u5185\u5916\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/strong><\/h2>\n\n\n\n<p>\u73fe\u5728\u3001\u7c73\u56fd\u7cd6\u5c3f\u75c5\u5b66\u4f1a\uff08ADA\uff09\u3084\u7c73\u56fd\u80a5\u6e80\u5b66\u4f1a\uff08ASMBS\uff09\u3067\u306f\u3001BMI 30\u4ee5\u4e0a\u3001\u307e\u305f\u306fBMI 27\u4ee5\u4e0a\u3067\u80a5\u6e80\u95a2\u9023\u5408\u4f75\u75c7\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u5bfe\u3057\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u4f7f\u7528\u3092\u63a8\u5968\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u3001\u4f53\u91cd\u6e1b\u5c11\u3068\u8840\u7cd6\u6539\u5584\u306e\u4e21\u65b9\u3092\u540c\u6642\u306b\u9054\u6210\u3067\u304d\u308b\u70b9\u304c\u9ad8\u304f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u56fd\u5185\u3067\u306f\u307e\u3060\u4fdd\u967a\u9069\u7528\u306f\u9650\u5b9a\u7684\u3067\u3059\u304c\u3001\u81ea\u7531\u8a3a\u7642\u3067\u306e\u4f7f\u7528\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u81e8\u5e8a\u73fe\u5834\u3067\u306f\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u304c\u96e3\u3057\u3044\u60a3\u8005\u306b\u5bfe\u3059\u308b\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u65e5\u672c\u4eba\u5bfe\u8c61\u306e\u5927\u898f\u6a21\u81e8\u5e8a\u30c7\u30fc\u30bf\u306e\u84c4\u7a4d\u306b\u3088\u308a\u3001\u56fd\u5185\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306e\u63a8\u5968\u304c\u62e1\u5927\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9ad8\u30ea\u30b9\u30af\u7fa4\u3078\u306e\u9069\u7528\u3068\u6ce8\u610f\u70b9<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u6bd4\u8f03\u7684\u5b89\u5168\u6027\u306e\u9ad8\u3044\u85ac\u5264\u3067\u3059\u304c\u3001\u4ee5\u4e0b\u306e\u60a3\u8005\u306b\u306f\u614e\u91cd\u306a\u6295\u4e0e\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u81b5\u708e\u306e\u65e2\u5f80\u6b74\u304c\u3042\u308b\u60a3\u8005<\/strong><strong><br><\/strong> GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u81b5\u708e\u30ea\u30b9\u30af\u3092\u308f\u305a\u304b\u306b\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u91cd\u5ea6\u306e\u814e\u969c\u5bb3\u60a3\u8005<\/strong><strong><br><\/strong> \u814e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u6d88\u5316\u5668\u75c7\u72b6\u304c\u5897\u5f37\u3059\u308b\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u598a\u5a20\u30fb\u6388\u4e73\u4e2d\u306e\u5973\u6027<\/strong><strong><br><\/strong> \u5b89\u5168\u6027\u30c7\u30fc\u30bf\u304c\u5341\u5206\u3067\u306a\u3044\u305f\u3081\u3001\u6295\u4e0e\u306f\u539f\u5247\u63a7\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<p>\u6295\u4e0e\u524d\u306b\u306f\u5fc5\u305a\u533b\u5e2b\u306b\u3088\u308b\u9069\u5207\u306a\u8a55\u4fa1\u3068\u8aac\u660e\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\u3068\u5c55\u671b<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u7814\u7a76\u306f\u6b27\u7c73\u3092\u4e2d\u5fc3\u306b\u9032\u3093\u3067\u3044\u307e\u3059\u304c\u3001\u4ee5\u4e0b\u306e\u8ab2\u984c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u9577\u671f\u7684\u306a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><strong><br><\/strong> STEP\u8a66\u9a13\u30b7\u30ea\u30fc\u30ba\u3067\u306f\u77ed\u671f\uff5e\u4e2d\u671f\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3078\u306e\u5f71\u97ff\u306f\u826f\u597d\u3067\u3057\u305f\u304c\u300110\u5e74\u4ee5\u4e0a\u306e\u9577\u671f\u30c7\u30fc\u30bf\u306f\u307e\u3060\u5341\u5206\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br><\/li>\n\n\n\n<li><strong>\u30a2\u30b8\u30a2\u4eba\u306b\u304a\u3051\u308b\u6709\u52b9\u6027\u306e\u691c\u8a3c<\/strong><strong><br><\/strong> \u65e5\u672c\u4eba\u3084\u30a2\u30b8\u30a2\u4eba\u5bfe\u8c61\u306e\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13\u306f\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u4eba\u7a2e\u5dee\u306b\u3088\u308b\u85ac\u52b9\u30fb\u526f\u4f5c\u7528\u306e\u9055\u3044\u3092\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u6700\u9069\u306a\u4f75\u7528\u65b9\u6cd5\u306e\u691c\u8a0e<\/strong><strong><br><\/strong> \u98df\u4e8b\u5236\u9650\u30fb\u904b\u52d5\u7642\u6cd5\u30fb\u5fc3\u7406\u30b5\u30dd\u30fc\u30c8\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u6700\u9069\u306a\u6cbb\u7642\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u304c\u4eca\u5f8c\u306e\u8ab2\u984c\u3067\u3059\u3002<br><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u5c06\u6765\u7684\u306a\u81e8\u5e8a\u5fdc\u7528\u30b7\u30ca\u30ea\u30aa<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u80a5\u6e80\u4e88\u9632\u3078\u306e\u5fdc\u7528<\/strong><strong><br><\/strong> BMI\u304c\u9ad8\u3081\u3060\u304c\u80a5\u6e80\u95a2\u9023\u75be\u60a3\u3092\u307e\u3060\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u4eba\u306b\u5bfe\u3057\u3066\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u3092\u77ed\u671f\u7684\u306b\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u80a5\u6e80\u9032\u884c\u3092\u4e88\u9632\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u8853\u524d\u6e1b\u91cf\u306e\u88dc\u52a9<\/strong><strong><br><\/strong> \u5fc3\u81d3\u624b\u8853\u3084\u6574\u5f62\u5916\u79d1\u624b\u8853\u524d\u306e\u6e1b\u91cf\u304c\u5fc5\u8981\u306a\u60a3\u8005\u306b\u5bfe\u3057\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u77ed\u671f\u9593\u3067\u306e\u4f53\u91cd\u6e1b\u5c11\u3092\u4fc3\u3059\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u6709\u7528\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u591a\u5264\u4f75\u7528\u7642\u6cd5\u306e\u4e00\u74b0<\/strong><strong><br><\/strong> \u65e2\u5b58\u306e\u80a5\u6e80\u6cbb\u7642\u85ac\u3084\u7cd6\u5c3f\u75c5\u85ac\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u5408\u308f\u305b\u305f\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u6cbb\u7642\u304c\u53ef\u80fd\u3067\u3059\u3002<br><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001\u7d4c\u53e3\u6295\u4e0e\u53ef\u80fd\u306aGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u3057\u3066\u3001\u80a5\u6e80\u60a3\u8005\u306e\u4f53\u91cd\u6e1b\u5c11\u306b\u9ad8\u3044\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6d88\u5316\u5668\u75c7\u72b6\u304c\u4e3b\u306a\u526f\u4f5c\u7528\u3067\u3059\u304c\u3001\u591a\u304f\u306f\u8efd\u5ea6\u3067\u3042\u308a\u3001\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u4f75\u7528\u3067\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3092\u6700\u5927\u5316\u3067\u304d\u307e\u3059\u3002\u7279\u306b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3084BMI\u304c\u9ad8\u304f\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3060\u3051\u3067\u306f\u4f53\u91cd\u7ba1\u7406\u304c\u56f0\u96e3\u306a\u60a3\u8005\u306b\u3068\u3063\u3066\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u65b0\u305f\u306a\u9078\u629e\u80a2\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u306f\u56fd\u5185\u3067\u306e\u5927\u898f\u6a21\u81e8\u5e8a\u7814\u7a76\u3068\u9577\u671f\u5b89\u5168\u6027\u306e\u8a55\u4fa1\u304c\u5f85\u305f\u308c\u308b\u6bb5\u968e\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e\u30fb\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Wilding JPH, et al. <em>Once-Weekly Semaglutide in Adults with Overweight or Obesity<\/em>. N Engl J Med. 2021;384:989\u20131002. <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2032183\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2032183<\/a><br><\/li>\n\n\n\n<li>Rubino D, et al. <em>Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults with Overweight or Obesity<\/em>. JAMA. 2021;325(14):1414\u20131425. <a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2780933\">https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2780933<\/a><br><\/li>\n\n\n\n<li>Davies M, et al. <em>Efficacy and Safety of Once-Weekly Semaglutide Versus Placebo as Add-on to Standard of Care in Type 2 Diabetes: STEP 2 Trial<\/em>. Lancet. 2021;397:971\u2013984. <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)00213-5\/fulltext\">https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)00213-5\/fulltext<\/a><br><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u306f\u3058\u3081\u306b 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STEP\u8a66\u9a13\u30b7\u30ea\u30fc\u30ba \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u306f\u3001\u591a\u304f\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u6ce8\u76ee\u3055\u308c\u308b\u306e\u306f\u3001STEP\u8a66\u9a13\u30b7\u30ea\u30fc\u30ba\u3067\u3059\u3002STEP1\u3067\u306f\u3001\u80a5\u6e80\u307e\u305f\u306f\u904e\u4f53\u91cd\u306e\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u3092\u7528\u3044\u305f\u9577\u671f\u6295\u4e0e\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u300152\u9031\u9593\u306e\u6295\u4e0e\u5f8c\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11\u306f8\u301c10\uff05\u3068\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Wilding JPH et al., N Engl J Med, 2021\uff09\u3002 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