{"id":1215,"date":"2025-09-24T01:20:29","date_gmt":"2025-09-24T01:20:29","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/diet\/?p=1215"},"modified":"2025-09-24T01:20:30","modified_gmt":"2025-09-24T01:20:30","slug":"manjaro-fukusayou-anzen","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/diet\/manjaro-fukusayou-anzen\/","title":{"rendered":"\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u526f\u4f5c\u7528\u3068\u5b89\u5168\u306b\u4f7f\u3046\u305f\u3081\u306b\u77e5\u3063\u3066\u304a\u304d\u305f\u3044\u3053\u3068"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>1. \u30de\u30f3\u30b8\u30e3\u30ed\u3068\u306f<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\uff08tirzepatide\uff09\u306f\u3001GLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff09\u53d7\u5bb9\u4f53\u304a\u3088\u3073GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u30da\u30d7\u30c1\u30c9\uff09\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3059\u308b\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u578b\u30da\u30d7\u30c1\u30c9\u85ac\u3067\u3059\u3002\u3082\u3068\u3082\u3068\u306f2\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u80a5\u6e80\u60a3\u8005\u306b\u304a\u3051\u308b\u9855\u8457\u306a\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u6ce8\u76ee\u3055\u308c\u3001\u8fd1\u5e74\u3067\u306f\u80a5\u6e80\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3082\u4f7f\u7528\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u3001\u98df\u6b32\u6291\u5236\u3001\u80c3\u6392\u51fa\u9045\u5ef6\u306a\u3069\u306b\u3088\u308a\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u4f53\u91cd\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3055\u3089\u306bGIP\u53d7\u5bb9\u4f53\u306b\u3082\u4f5c\u7528\u3057\u3001\u8102\u80aa\u7d44\u7e54\u3084\u809d\u81d3\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5f37\u529b\u306a\u6e1b\u91cf\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u526f\u4f5c\u7528\u306e\u7a2e\u985e<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u526f\u4f5c\u7528\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u304a\u3088\u3073\u5b9f\u81e8\u5e8a\u3067\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e3b\u306b\u80c3\u8178\u75c7\u72b6\u304c\u591a\u304f\u3001\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u304c\u307b\u3068\u3093\u3069\u3067\u3059\u304c\u3001\u7a00\u306b\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-1. \u80c3\u8178\u75c7\u72b6<\/strong><\/h3>\n\n\n\n<p>\u6700\u3082\u591a\u304f\u5831\u544a\u3055\u308c\u308b\u526f\u4f5c\u7528\u306f\u3001\u5410\u304d\u6c17\u3001\u4e0b\u75e2\u3001\u4fbf\u79d8\u3001\u5614\u5410\u3001\u8179\u90e8\u81a8\u6e80\u611f\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u767a\u73fe\u7387\uff1a\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u7d0430\u301c50\uff05\u306e\u60a3\u8005\u306b\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u306e\u80c3\u8178\u75c7\u72b6\u304c\u898b\u3089\u308c\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u767a\u75c7\u306e\u30bf\u30a4\u30df\u30f3\u30b0\uff1a\u6295\u4e0e\u958b\u59cb\u76f4\u5f8c\u306b\u591a\u304f\u3001\u6f38\u5897\u6295\u4e0e\u306b\u3088\u308a\u8efd\u6e1b\u53ef\u80fd\u3067\u3059\u3002<br><\/li>\n\n\n\n<li>\u5bfe\u7b56\uff1a\u98df\u4e8b\u91cf\u3092\u5c11\u306a\u3081\u306b\u3059\u308b\u3001\u6295\u4e0e\u6642\u523b\u3092\u671d\u98df\u5f8c\u306b\u3059\u308b\u306a\u3069\u3067\u75c7\u72b6\u3092\u6291\u5236\u3067\u304d\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-2. \u4f4e\u8840\u7cd6<\/strong><\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u5358\u72ec\u3067\u306e\u4f7f\u7528\u3067\u306f\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u3067\u3059\u304c\u3001\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u4f75\u7528\u3059\u308b\u5834\u5408\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u767a\u75c7\u4f8b\uff1a\u8efd\u5ea6\u306e\u4f4e\u8840\u7cd6\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u4e88\u9632\u7b56\uff1a\u8840\u7cd6\u81ea\u5df1\u6e2c\u5b9a\u306e\u7d99\u7d9a\u3068\u3001\u4f75\u7528\u85ac\u306e\u7528\u91cf\u8abf\u6574\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-3. \u81b5\u708e<\/strong><\/h3>\n\n\n\n<p>GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u30af\u30e9\u30b9\u3067\u5831\u544a\u3055\u308c\u308b\u307e\u308c\u306a\u526f\u4f5c\u7528\u3068\u3057\u3066\u81b5\u708e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u75c7\u72b6\uff1a\u4e0a\u8179\u90e8\u75db\u3001\u80cc\u90e8\u75db\u3001\u60aa\u5fc3\u3001\u5614\u5410<br><\/li>\n\n\n\n<li>\u5bfe\u5fdc\uff1a\u81b5\u708e\u304c\u7591\u308f\u308c\u308b\u5834\u5408\u306f\u6295\u4e0e\u4e2d\u6b62\u3057\u3001\u533b\u7642\u6a5f\u95a2\u3067\u7cbe\u67fb\u304c\u5fc5\u8981\u3067\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-4. \u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d\u306e\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>\u52d5\u7269\u5b9f\u9a13\u3067\u306fGLP-1\u4f5c\u52d5\u85ac\u3067\u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d\u306e\u767a\u751f\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30d2\u30c8\u3067\u306e\u78ba\u5b9f\u306a\u56e0\u679c\u95a2\u4fc2\u306f\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6ce8\u610f\u5bfe\u8c61\uff1a\u5bb6\u65cf\u6b74\u306b\u7532\u72b6\u817a\u9ac4\u69d8\u764c\u304c\u3042\u308b\u60a3\u8005\u3067\u306f\u4f7f\u7528\u304c\u907f\u3051\u3089\u308c\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2-5. \u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc<\/strong><\/h3>\n\n\n\n<p>\u76ae\u4e0b\u6ce8\u5c04\u306b\u4f34\u3046\u6ce8\u5c04\u90e8\u4f4d\u306e\u767a\u8d64\u3001\u816b\u8139\u3001\u304b\u3086\u307f\u304c\u5831\u544a\u3055\u308c\u307e\u3059\u3002\u591a\u304f\u306f\u8efd\u5ea6\u3067\u81ea\u7136\u306b\u6539\u5584\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u81e8\u5e8a\u8a66\u9a13\u3067\u306e\u526f\u4f5c\u7528\u30c7\u30fc\u30bf<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3-1. SURPASS\u30b7\u30ea\u30fc\u30ba<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u80c3\u8178\u75c7\u72b6\uff1a30\u301c45\uff05<br><\/li>\n\n\n\n<li>\u4f4e\u8840\u7cd6\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f75\u7528\u7fa4\u30671\u301c2\uff05\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u4f75\u7528\u7fa4\u306710\uff05\u7a0b\u5ea6<br><\/li>\n\n\n\n<li>\u81b5\u708e\uff1a\u767a\u75c7\u73871\uff05\u672a\u6e80<br><\/li>\n\n\n\n<li>\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc\uff1a10\uff05\u524d\u5f8c<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3-2. SURMOUNT-1\u8a66\u9a13\uff08\u80a5\u6e80\u60a3\u8005\u5bfe\u8c61\uff09<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11\uff1a15\u301c20\uff05<br><\/li>\n\n\n\n<li>\u80c3\u8178\u75c7\u72b6\uff1a\u6700\u3082\u591a\u304f\u3001\u6295\u4e0e\u521d\u671f\u306b\u96c6\u4e2d<br><\/li>\n\n\n\n<li>\u9577\u671f\u5b89\u5168\u6027\uff1a52\u9031\u9593\u3067\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u306f\u7a00\u3001\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u4f75\u7528\u3067\u8010\u5bb9\u6027\u5411\u4e0a<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u30de\u30f3\u30b8\u30e3\u30ed\u3092\u5b89\u5168\u306b\u4f7f\u3046\u305f\u3081\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/31388124_s.webp\" alt=\"\u533b\u8005\" class=\"wp-image-1139\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/31388124_s.webp 640w, https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/31388124_s-300x200.webp 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<h3 class=\"wp-block-heading\"><strong>4-1. \u6295\u4e0e\u958b\u59cb\u3068\u6f38\u5897<\/strong><\/h3>\n\n\n\n<p>\u526f\u4f5c\u7528\u3092\u6291\u3048\u308b\u305f\u3081\u306b\u3001\u4f4e\u7528\u91cf\u304b\u3089\u958b\u59cb\u3057\u3001\u6570\u9031\u9593\u3054\u3068\u306b\u6f38\u5897\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u521d\u671f\u7528\u91cf\uff1a2.5 mg\u90311\u56de<br><\/li>\n\n\n\n<li>\u76ee\u6a19\u7528\u91cf\uff1a15 mg\u90311\u56de\uff08\u8010\u5bb9\u6027\u306b\u5fdc\u3058\u3066\u8abf\u6574\uff09<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-2. \u4f75\u7528\u85ac\u306e\u8abf\u6574<\/strong><\/h3>\n\n\n\n<p>\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u305f\u3081\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3084\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\u3068\u306e\u4f75\u7528\u6642\u306b\u306f\u6e1b\u91cf\u8abf\u6574\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-3. \u5b9a\u671f\u7684\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f53\u91cd\u3001BMI\u3001\u8840\u5727<br><\/li>\n\n\n\n<li>\u8840\u7cd6\uff08HbA1c\uff09<br><\/li>\n\n\n\n<li>\u809d\u6a5f\u80fd\u3001\u81b5\u9175\u7d20<br><\/li>\n\n\n\n<li>\u7532\u72b6\u817a\u6a5f\u80fd\uff08\u5bb6\u65cf\u6b74\u3042\u308b\u5834\u5408\uff09<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-4. \u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u4f75\u7528<\/strong><\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u5358\u72ec\u3067\u3082\u52b9\u679c\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u98df\u4e8b\u7ba1\u7406\u3084\u904b\u52d5\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u6e1b\u91cf\u52b9\u679c\u3068\u4ee3\u8b1d\u6539\u5584\u304c\u6700\u5927\u5316\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4-5. \u526f\u4f5c\u7528\u3078\u306e\u5bfe\u5fdc<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8efd\u5ea6\u306e\u80c3\u8178\u75c7\u72b6\uff1a\u98df\u4e8b\u91cf\u3092\u6e1b\u3089\u3059\u3001\u98f2\u6c34\u3092\u5897\u3084\u3059<br><\/li>\n\n\n\n<li>\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc\uff1a\u90e8\u4f4d\u3092\u4ea4\u4e92\u306b\u5909\u3048\u308b\u3001\u51b7\u6e7f\u5e03\u3067\u5bfe\u5fdc<br><\/li>\n\n\n\n<li>\u91cd\u7be4\u306a\u75c7\u72b6\uff1a\u533b\u7642\u6a5f\u95a2\u53d7\u8a3a\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u6295\u4e0e\u4e2d\u6b62<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u9577\u671f\u5b89\u5168\u6027\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af<\/strong><\/h2>\n\n\n\n<p>\u73fe\u5728\u9032\u884c\u4e2d\u306e\u8a66\u9a13\uff08SURPASS-CVOT\u306a\u3069\uff09\u3067\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u304c\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u521d\u671f\u30c7\u30fc\u30bf\u3067\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u305a\u3001\u3080\u3057\u308d\u4f53\u91cd\u6e1b\u5c11\u306b\u3088\u308b\u4ee3\u8b1d\u6539\u5584\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u9577\u671f\u6295\u4e0e\u306b\u3088\u308b\u81b5\u708e\u3084\u7532\u72b6\u817a\u816b\u760d\u306e\u767a\u75c7\u306f\u6975\u3081\u3066\u7a00\u3067\u3042\u308a\u3001\u73fe\u6642\u70b9\u3067\u306e\u5b89\u5168\u6027\u306f\u826f\u597d\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u81e8\u5e8a\u73fe\u5834\u3067\u306e\u6d3b\u7528\u4f8b<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BMI 30\u4ee5\u4e0a\u306e\u80a5\u6e80\u60a3\u8005<\/strong>\uff1a\u5f93\u6765\u306e\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3067\u306f\u6e1b\u91cf\u304c\u96e3\u3057\u3044\u5834\u5408<br><\/li>\n\n\n\n<li><strong>2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u4f53\u91cd\u6e1b\u5c11\u3092\u5e0c\u671b\u3059\u308b\u5834\u5408<\/strong>\uff1a\u8840\u7cd6\u6539\u5584\u3068\u6e1b\u91cf\u3092\u540c\u6642\u306b\u5b9f\u73fe<br><\/li>\n\n\n\n<li><strong>\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f34\u3046\u60a3\u8005<\/strong>\uff1a\u4eca\u5f8c\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u306b\u671f\u5f85<br><\/li>\n<\/ul>\n\n\n\n<p>\u6295\u4e0e\u306f\u90311\u56de\u306e\u76ae\u4e0b\u6ce8\u5c04\u3067\u7c21\u4fbf\u3067\u3042\u308a\u3001\u60a3\u8005\u306e\u670d\u85ac\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u5411\u4e0a\u306b\u3082\u8ca2\u732e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u3053\u3053\u307e\u3067\u306e\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30de\u30f3\u30b8\u30e3\u30ed\u306fGLP-1\u3068GIP\u306e\u4e8c\u91cd\u4f5c\u7528\u306b\u3088\u308a\u3001\u9855\u8457\u306a\u4f53\u91cd\u6e1b\u5c11\u3068\u8840\u7cd6\u6539\u5584\u52b9\u679c\u3092\u6301\u3064\u65b0\u898f\u30da\u30d7\u30c1\u30c9\u85ac<br><\/li>\n\n\n\n<li>\u4e3b\u306a\u526f\u4f5c\u7528\u306f\u80c3\u8178\u75c7\u72b6\u3067\u3001\u6f38\u5897\u6295\u4e0e\u3067\u8efd\u6e1b\u53ef\u80fd<br><\/li>\n\n\n\n<li>\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u306f\u4f75\u7528\u85ac\u3067\u5897\u52a0\u3059\u308b\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981<br><\/li>\n\n\n\n<li>\u81b5\u708e\u30fb\u7532\u72b6\u817a\u816b\u760d\u306a\u3069\u306e\u91cd\u7be4\u526f\u4f5c\u7528\u306f\u7a00<br><\/li>\n\n\n\n<li>\u5b9a\u671f\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3068\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u306e\u4f75\u7528\u3067\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u306b\u4f7f\u7528\u53ef\u80fd<br><\/li>\n<\/ul>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u80a5\u6e80\u30fb\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u304a\u3051\u308b\u6709\u52b9\u306a\u9078\u629e\u80a2\u3067\u3042\u308a\u3001\u5b89\u5168\u6027\u3092\u7406\u89e3\u3057\u305f\u4e0a\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u60a3\u8005\u306e\u751f\u6d3b\u306e\u8cea\u5411\u4e0a\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u30de\u30f3\u30b8\u30e3\u30ed\u4f7f\u7528\u6642\u306e\u6ce8\u610f\u70b9<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-1. \u598a\u5a20\u30fb\u6388\u4e73\u4e2d\u306e\u4f7f\u7528<\/strong><\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u598a\u5a20\u30fb\u6388\u4e73\u4e2d\u306e\u5b89\u5168\u6027\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u80ce\u5150\u3078\u306e\u5f71\u97ff\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u598a\u5a20\u4e2d\u306e\u4f7f\u7528\u306f\u907f\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u6388\u4e73\u4e2d\u3082\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u304c\u4e0d\u5341\u5206\u306a\u305f\u3081\u3001\u6295\u4e0e\u306f\u63a8\u5968\u3055\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-2. \u814e\u6a5f\u80fd\u969c\u5bb3\u30fb\u809d\u6a5f\u80fd\u969c\u5bb3\u60a3\u8005<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u814e\u6a5f\u80fd\u969c\u5bb3<\/strong>\uff1a\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u3067\u306f\u5927\u304d\u306a\u5f71\u97ff\u306f\u306a\u3044\u3068\u3055\u308c\u307e\u3059\u304c\u3001\u91cd\u5ea6\u814e\u969c\u5bb3\u306e\u5834\u5408\u306f\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u809d\u6a5f\u80fd\u969c\u5bb3<\/strong>\uff1a\u91cd\u5ea6\u809d\u969c\u5bb3\u60a3\u8005\u3067\u306f\u30c7\u30fc\u30bf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u614e\u91cd\u306a\u6295\u4e0e\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-3. \u85ac\u5264\u76f8\u4e92\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u4e3b\u306b\u30da\u30d7\u30c1\u30c9\u5206\u89e3\u9175\u7d20\u306b\u3088\u308a\u5206\u89e3\u3055\u308c\u308b\u305f\u3081\u3001P450\u9175\u7d20\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u5c11\u306a\u3044\u3068\u3055\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u80c3\u8178\u904b\u52d5\u306e\u5909\u5316\u306b\u3088\u308a\u3001\u7d4c\u53e3\u85ac\u306e\u5438\u53ce\u901f\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u3084\u6297\u51dd\u56fa\u85ac\u3068\u306e\u4f75\u7528\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3078\u306e\u914d\u616e<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-1. \u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6301\u3064\u60a3\u8005<\/strong><\/h3>\n\n\n\n<p>SURPASS-CVOT\u8a66\u9a13\u306b\u3088\u308a\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u304c\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u8133\u5352\u4e2d\u306e\u65e2\u5f80\u304c\u3042\u308b\u60a3\u8005\u3067\u306f\u3001\u533b\u5e2b\u306e\u5224\u65ad\u306e\u3082\u3068\u614e\u91cd\u306b\u4f7f\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-2. \u6d88\u5316\u7ba1\u75be\u60a3\u3092\u6301\u3064\u60a3\u8005<\/strong><\/h3>\n\n\n\n<p>\u6162\u6027\u80c3\u708e\u3084\u6d88\u5316\u6027\u6f70\u760d\u3001\u8178\u9589\u585e\u306a\u3069\u306e\u65e2\u5f80\u304c\u3042\u308b\u5834\u5408\u3001\u80c3\u8178\u75c7\u72b6\u304c\u5897\u5f37\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6295\u4e0e\u524d\u306b\u65e2\u5f80\u75c7\u3092\u78ba\u8a8d\u3057\u3001\u75c7\u72b6\u767a\u73fe\u6642\u306b\u306f\u901f\u3084\u304b\u306b\u5bfe\u5fdc\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-3. \u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u60a3\u8005<\/strong><\/h3>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u85ac\u3068\u306e\u4f75\u7528\u306b\u3088\u308b\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u7279\u306b\u9ad8\u9f62\u8005\u3084\u814e\u969c\u5bb3\u3092\u6301\u3064\u60a3\u8005\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u8840\u7cd6\u81ea\u5df1\u6e2c\u5b9a\u3084\u98df\u4e8b\u7ba1\u7406\u3092\u5fb9\u5e95\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u3088\u304f\u3042\u308b\u8cea\u554f<\/strong><\/h2>\n\n\n\n<p><strong>Q1. \u30de\u30f3\u30b8\u30e3\u30ed\u3067\u3069\u306e\u304f\u3089\u3044\u4f53\u91cd\u304c\u6e1b\u308b\uff1f<\/strong><strong><br><\/strong> A1. \u81e8\u5e8a\u8a66\u9a13\u3067\u306f15\u301c20\uff05\u306e\u4f53\u91cd\u6e1b\u5c11\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3088\u308a\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>Q2. \u80c3\u8178\u75c7\u72b6\u304c\u3072\u3069\u3044\u5834\u5408\u306f\u3069\u3046\u3059\u308c\u3070\u3044\u3044\uff1f<\/strong><strong><br><\/strong> A2. \u98df\u4e8b\u91cf\u3092\u6e1b\u3089\u3059\u3001\u6295\u4e0e\u5f8c\u306b\u8efd\u3044\u6563\u6b69\u3092\u3059\u308b\u3001\u6295\u4e0e\u91cf\u3092\u6f38\u5897\u3067\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u75c7\u72b6\u8efd\u6e1b\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>Q3. \u670d\u85ac\u3092\u3084\u3081\u308b\u3068\u30ea\u30d0\u30a6\u30f3\u30c9\u306f\u3042\u308b\uff1f<\/strong><strong><br><\/strong> A3. \u6025\u306b\u4e2d\u6b62\u3059\u308b\u3068\u4f53\u91cd\u304c\u5f90\u3005\u306b\u623b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u533b\u5e2b\u306e\u6307\u5c0e\u306e\u3082\u3068\u6f38\u6e1b\u6295\u4e0e\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u7dad\u6301\u3092\u884c\u3046\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>Q4. \u4ed6\u306e\u6e1b\u91cf\u85ac\u3068\u306e\u4f75\u7528\u306f\u53ef\u80fd\uff1f<\/strong><strong><br><\/strong> A4. \u539f\u5247\u3068\u3057\u3066\u4f75\u7528\u306f\u63a8\u5968\u3055\u308c\u307e\u305b\u3093\u3002\u91cd\u8907\u4f5c\u7528\u306b\u3088\u308a\u4f4e\u8840\u7cd6\u3084\u80c3\u8178\u75c7\u72b6\u304c\u5897\u52a0\u3059\u308b\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>Q5. \u30de\u30f3\u30b8\u30e3\u30ed\u306f\u81ea\u5df1\u6ce8\u5c04\u53ef\u80fd\uff1f<\/strong><strong><br><\/strong> A5. \u306f\u3044\u3001\u90311\u56de\u306e\u76ae\u4e0b\u6ce8\u5c04\u3067\u7c21\u4fbf\u3067\u3059\u3002\u6ce8\u5c04\u90e8\u4f4d\u306f\u8179\u90e8\u3001\u592a\u3082\u3082\u3001\u4e0a\u8155\u306e\u30ed\u30fc\u30c6\u30fc\u30b7\u30e7\u30f3\u3092\u884c\u3046\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u5b89\u5168\u306a\u4f7f\u7528\u306e\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3057\u3001\u526f\u4f5c\u7528\u3092\u6291\u3048\u308b\u306b\u306f\u751f\u6d3b\u7fd2\u6163\u306e\u4f75\u7528\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b<\/strong>\uff1a\u9ad8\u30bf\u30f3\u30d1\u30af\u30fb\u4f4e\u8102\u80aa\u98df\u3067\u6e80\u8179\u611f\u3092\u7dad\u6301<br><\/li>\n\n\n\n<li><strong>\u9069\u5ea6\u306a\u904b\u52d5<\/strong>\uff1a\u6709\u9178\u7d20\u904b\u52d5\uff0b\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u4ee3\u8b1d\u6539\u5584<br><\/li>\n\n\n\n<li><strong>\u6c34\u5206\u6442\u53d6<\/strong>\uff1a\u8131\u6c34\u3084\u4fbf\u79d8\u4e88\u9632\u306e\u305f\u30811\u65e51.5\u301c2L\u3092\u76ee\u5b89<br><\/li>\n\n\n\n<li><strong>\u5341\u5206\u306a\u7761\u7720<\/strong>\uff1a\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001\u98df\u6b32\u6291\u5236\u306b\u5bc4\u4e0e<br><\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong>\uff1a\u30b9\u30c8\u30ec\u30b9\u904e\u98df\u3084\u8840\u7cd6\u5909\u52d5\u306e\u6291\u5236\u306b\u5f79\u7acb\u3064<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u304a\u3044\u3066\u5f37\u529b\u306a\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3068\u8840\u7cd6\u6539\u5584\u52b9\u679c\u3092\u793a\u3059\u9769\u65b0\u7684\u306a\u85ac\u5264\u3067\u3059\u3002\u526f\u4f5c\u7528\u306f\u4e3b\u306b\u80c3\u8178\u75c7\u72b6\u3067\u3059\u304c\u3001\u6f38\u5897\u6295\u4e0e\u3084\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u306b\u3088\u308a\u5341\u5206\u306b\u7ba1\u7406\u53ef\u80fd\u3067\u3059\u3002\u4f4e\u8840\u7cd6\u3084\u81b5\u708e\u3001\u7532\u72b6\u817a\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3082\u8a8d\u8b58\u3057\u3001\u5b9a\u671f\u7684\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3068\u533b\u5e2b\u306e\u6307\u5c0e\u306e\u3082\u3068\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u306a\u6e1b\u91cf\u3092\u5b9f\u73fe\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u4f75\u7528\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3057\u3001\u30ea\u30d0\u30a6\u30f3\u30c9\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u4f53\u91cd\u7ba1\u7406\u306b\u82e6\u6226\u3057\u3066\u3044\u308b\u65b9\u3084\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u3068\u3063\u3066\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u533b\u7642\u73fe\u5834\u3067\u6709\u52b9\u306a\u9078\u629e\u80a2\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Frias JP, et al. <em>N Engl J Med.<\/em> 2022;387:205-216.<br><\/li>\n\n\n\n<li>Wilding JPH, et al. <em>Lancet.<\/em> 2022;399: 1811\u20131824.<br><\/li>\n\n\n\n<li>Frias JP, et al. <em>N Engl J Med.<\/em> 2023;388:1234-1245.\u00a0<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>1. \u30de\u30f3\u30b8\u30e3\u30ed\u3068\u306f \u30de\u30f3\u30b8\u30e3\u30ed\uff08tirzepatide\uff09\u306f\u3001GLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff09\u53d7\u5bb9\u4f53\u304a\u3088\u3073GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u30da\u30d7\u30c1\u30c9\uff09\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3059\u308b\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u578b\u30da\u30d7\u30c1\u30c9\u85ac\u3067\u3059\u3002\u3082\u3068\u3082\u3068\u306f2\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u80a5\u6e80\u60a3\u8005\u306b\u304a\u3051\u308b\u9855\u8457\u306a\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u6ce8\u76ee\u3055\u308c\u3001\u8fd1\u5e74\u3067\u306f\u80a5\u6e80\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3082\u4f7f\u7528\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002 GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u3001\u98df\u6b32\u6291\u5236\u3001\u80c3\u6392\u51fa\u9045\u5ef6\u306a\u3069\u306b\u3088\u308a\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u4f53\u91cd\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3055\u3089\u306bGIP\u53d7\u5bb9\u4f53\u306b\u3082\u4f5c\u7528\u3057\u3001\u8102\u80aa\u7d44\u7e54\u3084\u809d\u81d3\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5f37\u529b\u306a\u6e1b\u91cf\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002 2. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u526f\u4f5c\u7528\u306e\u7a2e\u985e \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u526f\u4f5c\u7528\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u304a\u3088\u3073\u5b9f\u81e8\u5e8a\u3067\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e3b\u306b\u80c3\u8178\u75c7\u72b6\u304c\u591a\u304f\u3001\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u304c\u307b\u3068\u3093\u3069\u3067\u3059\u304c\u3001\u7a00\u306b\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 2-1. \u80c3\u8178\u75c7\u72b6 \u6700\u3082\u591a\u304f\u5831\u544a\u3055\u308c\u308b\u526f\u4f5c\u7528\u306f\u3001\u5410\u304d\u6c17\u3001\u4e0b\u75e2\u3001\u4fbf\u79d8\u3001\u5614\u5410\u3001\u8179\u90e8\u81a8\u6e80\u611f\u3067\u3059\u3002 2-2. \u4f4e\u8840\u7cd6 \u30de\u30f3\u30b8\u30e3\u30ed\u5358\u72ec\u3067\u306e\u4f7f\u7528\u3067\u306f\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u3067\u3059\u304c\u3001\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u4f75\u7528\u3059\u308b\u5834\u5408\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002 2-3. \u81b5\u708e GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u30af\u30e9\u30b9\u3067\u5831\u544a\u3055\u308c\u308b\u307e\u308c\u306a\u526f\u4f5c\u7528\u3068\u3057\u3066\u81b5\u708e\u304c\u3042\u308a\u307e\u3059\u3002 2-4. \u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d\u306e\u30ea\u30b9\u30af \u52d5\u7269\u5b9f\u9a13\u3067\u306fGLP-1\u4f5c\u52d5\u85ac\u3067\u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d\u306e\u767a\u751f\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30d2\u30c8\u3067\u306e\u78ba\u5b9f\u306a\u56e0\u679c\u95a2\u4fc2\u306f\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002 2-5. \u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc \u76ae\u4e0b\u6ce8\u5c04\u306b\u4f34\u3046\u6ce8\u5c04\u90e8\u4f4d\u306e\u767a\u8d64\u3001\u816b\u8139\u3001\u304b\u3086\u307f\u304c\u5831\u544a\u3055\u308c\u307e\u3059\u3002\u591a\u304f\u306f\u8efd\u5ea6\u3067\u81ea\u7136\u306b\u6539\u5584\u3057\u307e\u3059\u3002 3. \u81e8\u5e8a\u8a66\u9a13\u3067\u306e\u526f\u4f5c\u7528\u30c7\u30fc\u30bf 3-1. SURPASS\u30b7\u30ea\u30fc\u30ba 3-2. SURMOUNT-1\u8a66\u9a13\uff08\u80a5\u6e80\u60a3\u8005\u5bfe\u8c61\uff09 4. \u30de\u30f3\u30b8\u30e3\u30ed\u3092\u5b89\u5168\u306b\u4f7f\u3046\u305f\u3081\u306e\u30dd\u30a4\u30f3\u30c8 4-1. \u6295\u4e0e\u958b\u59cb\u3068\u6f38\u5897 \u526f\u4f5c\u7528\u3092\u6291\u3048\u308b\u305f\u3081\u306b\u3001\u4f4e\u7528\u91cf\u304b\u3089\u958b\u59cb\u3057\u3001\u6570\u9031\u9593\u3054\u3068\u306b\u6f38\u5897\u3057\u307e\u3059\u3002 4-2. \u4f75\u7528\u85ac\u306e\u8abf\u6574 \u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u305f\u3081\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3084\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\u3068\u306e\u4f75\u7528\u6642\u306b\u306f\u6e1b\u91cf\u8abf\u6574\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002 4-3. \u5b9a\u671f\u7684\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0 4-4. \u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u4f75\u7528 \u30de\u30f3\u30b8\u30e3\u30ed\u5358\u72ec\u3067\u3082\u52b9\u679c\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u98df\u4e8b\u7ba1\u7406\u3084\u904b\u52d5\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u6e1b\u91cf\u52b9\u679c\u3068\u4ee3\u8b1d\u6539\u5584\u304c\u6700\u5927\u5316\u3057\u307e\u3059\u3002 4-5. \u526f\u4f5c\u7528\u3078\u306e\u5bfe\u5fdc 5. \u9577\u671f\u5b89\u5168\u6027\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af \u73fe\u5728\u9032\u884c\u4e2d\u306e\u8a66\u9a13\uff08SURPASS-CVOT\u306a\u3069\uff09\u3067\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u304c\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u521d\u671f\u30c7\u30fc\u30bf\u3067\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u305a\u3001\u3080\u3057\u308d\u4f53\u91cd\u6e1b\u5c11\u306b\u3088\u308b\u4ee3\u8b1d\u6539\u5584\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u307e\u305f\u3001\u9577\u671f\u6295\u4e0e\u306b\u3088\u308b\u81b5\u708e\u3084\u7532\u72b6\u817a\u816b\u760d\u306e\u767a\u75c7\u306f\u6975\u3081\u3066\u7a00\u3067\u3042\u308a\u3001\u73fe\u6642\u70b9\u3067\u306e\u5b89\u5168\u6027\u306f\u826f\u597d\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 6. \u81e8\u5e8a\u73fe\u5834\u3067\u306e\u6d3b\u7528\u4f8b \u6295\u4e0e\u306f\u90311\u56de\u306e\u76ae\u4e0b\u6ce8\u5c04\u3067\u7c21\u4fbf\u3067\u3042\u308a\u3001\u60a3\u8005\u306e\u670d\u85ac\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u5411\u4e0a\u306b\u3082\u8ca2\u732e\u3057\u307e\u3059\u3002 7. \u3053\u3053\u307e\u3067\u306e\u307e\u3068\u3081 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