{"id":1222,"date":"2025-09-24T01:37:35","date_gmt":"2025-09-24T01:37:35","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/diet\/?p=1222"},"modified":"2025-09-24T01:37:36","modified_gmt":"2025-09-24T01:37:36","slug":"manjaro-taijuu-insulin-kaizen","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/diet\/manjaro-taijuu-insulin-kaizen\/","title":{"rendered":"\u30de\u30f3\u30b8\u30e3\u30ed\u3067\u671f\u5f85\u3055\u308c\u308b\u4f53\u91cd\u6e1b\u5c11\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0"},"content":{"rendered":"\n<p>\u80a5\u6e80\u30842\u578b\u7cd6\u5c3f\u75c5\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u3001\u4f53\u91cd\u6e1b\u5c11\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6539\u5584\u306f\u6cbb\u7642\u306e\u91cd\u8981\u306a\u76ee\u6a19\u3067\u3059\u3002\u8fd1\u5e74\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u4e2d\u3067\u3082<strong>\u30de\u30f3\u30b8\u30e3\u30ed<\/strong>\uff08tirzepatide\uff09\u306f\u3001\u5f93\u6765\u306e\u5358\u4e00GLP-1\u4f5c\u52d5\u85ac\u3068\u306f\u7570\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u3001\u3088\u308a\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3068\u8840\u7cd6\u6539\u5584\u3092\u793a\u3059\u3053\u3068\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7a3f\u3067\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u6a5f\u5e8f\u3001\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u81e8\u5e8a\u30c7\u30fc\u30bf\u3001\u305d\u3057\u3066\u4ed6\u306eGLP-1\u4f5c\u52d5\u85ac\u3068\u306e\u6bd4\u8f03\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u57fa\u790e\u77e5\u8b58<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001<strong>GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u30da\u30d7\u30c1\u30c9\uff09\u3068GLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff09\u3092\u540c\u6642\u306b\u523a\u6fc0\u3059\u308b\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u85ac<\/strong>\u3067\u3059\u3002\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306fGLP-1\u53d7\u5bb9\u4f53\u306b\u7279\u5316\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306fGIP\u53d7\u5bb9\u4f53\u306b\u3082\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u98df\u6b32\u6291\u5236\u306b\u3088\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u306e\u6e1b\u5c11<br><\/li>\n\n\n\n<li>\u8102\u8cea\u4ee3\u8b1d\u306e\u6539\u5584\u306b\u3088\u308b\u4f53\u8102\u80aa\u6e1b\u5c11<br><\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u5897\u52a0\u3068\u8840\u7cd6\u6539\u5584<br><\/li>\n\n\n\n<li>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6539\u5584<br><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u306b\u3088\u308a\u3001\u5f93\u6765\u85ac\u3088\u308a\u3082\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u5927\u304d\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u306f\u4e3b\u306b\u4ee5\u4e0b\u306e3\u3064\u306e\u7d4c\u8def\u3067\u8aac\u660e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.1 \u98df\u6b32\u4e2d\u67a2\u3078\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>GLP-1\u53d7\u5bb9\u4f53\u523a\u6fc0\u306b\u3088\u308a\u3001\u8133\u306e\u6e80\u8179\u4e2d\u67a2\u306b\u4fe1\u53f7\u304c\u4f1d\u308f\u308a\u3001\u98df\u6b32\u304c\u6291\u5236\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306bGIP\u4f5c\u7528\u3082\u76f8\u4e57\u7684\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6442\u98df\u884c\u52d5\u306e\u6291\u5236\u304c\u5f37\u5316\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u81ea\u7136\u306a\u30ab\u30ed\u30ea\u30fc\u6442\u53d6\u306e\u6e1b\u5c11\u304c\u8d77\u3053\u308a\u3001\u4f53\u91cd\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.2 \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u4fc3\u9032<\/strong><\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u81b5\u03b2\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3066\u3001\u8840\u7cd6\u5024\u306b\u5fdc\u3058\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u7279\u306b\u98df\u5f8c\u9ad8\u8840\u7cd6\u6642\u306b\u9855\u8457\u306a\u52b9\u679c\u3092\u793a\u3059\u305f\u3081\u3001\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u306f\u6bd4\u8f03\u7684\u4f4e\u304f\u6291\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.3 \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6539\u5584<\/strong><\/h3>\n\n\n\n<p>GIP\u4f5c\u7528\u306b\u3088\u3063\u3066\u672b\u68a2\u7d44\u7e54\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u6539\u5584\u3055\u308c\u307e\u3059\u3002\u8102\u80aa\u7d44\u7e54\u3084\u7b4b\u8089\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304c\u5897\u52a0\u3057\u3001\u8840\u7cd6\u306e\u6052\u5e38\u6027\u304c\u6539\u5584\u3055\u308c\u308b\u3068\u540c\u6642\u306b\u3001\u809d\u81d3\u3067\u306e\u7cd6\u65b0\u751f\u6291\u5236\u3082\u8d77\u3053\u308a\u307e\u3059\u3002\u3053\u306e\u7d50\u679c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u8efd\u6e1b\u3055\u308c\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u75c5\u614b\u6539\u5584\u306b\u3082\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u81e8\u5e8a\u8a66\u9a13\u3067\u306e\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u81e8\u5e8a\u8a66\u9a13\u3067\u3001\u5f93\u6765\u306eGLP-1\u4f5c\u52d5\u85ac\u3088\u308a\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4ee3\u8868\u7684\u306a\u8a66\u9a13\u306f<strong>SURPASS\u30b7\u30ea\u30fc\u30ba<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SURPASS-1\u8a66\u9a13\uff082\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5bfe\u8c61\u3001\u5358\u72ec\u6295\u4e0e\uff09<br>\n<ul class=\"wp-block-list\">\n<li>\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11\uff1a\u9031\u6295\u4e0e\u91cf15mg\u3067\u7d049.5kg<br><\/li>\n\n\n\n<li>HbA1c\u6539\u5584\uff1a\u7d042.0\uff05\u306e\u4f4e\u4e0b<br><\/li>\n\n\n\n<li>\u526f\u4f5c\u7528\uff1a\u4e3b\u306b\u6d88\u5316\u5668\u75c7\u72b6\uff08\u5410\u304d\u6c17\u3001\u4e0b\u75e2\uff09\u304c\u591a\u3044<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>SURPASS-2\u8a66\u9a13\uff08\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3068\u306e\u6bd4\u8f03\uff09<br>\n<ul class=\"wp-block-list\">\n<li>\u30de\u30f3\u30b8\u30e3\u30ed 15mg\uff1a\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11\u7d0413.1kg<br><\/li>\n\n\n\n<li>\u30bb\u30de\u30b0\u30eb\u30c1\u30c9 1mg\uff1a\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11\u7d0410.8kg<br><\/li>\n\n\n\n<li>\u4f53\u91cd\u6e1b\u5c11\u91cf\u306f\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u30de\u30f3\u30b8\u30e3\u30ed\u304c\u512a\u4f4d<br><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f<strong>\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u3082\u975e\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u3082\u9ad8\u3044\u6e1b\u91cf\u52b9\u679c<\/strong>\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/32942486_s-1.webp\" alt=\"\u533b\u7642\" class=\"wp-image-1185\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/32942486_s-1.webp 640w, https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/32942486_s-1-300x200.webp 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306b\u76f4\u63a5\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.1 \u8102\u80aa\u7d44\u7e54\u306e\u6539\u5584<\/strong><\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u5185\u81d3\u8102\u80aa\u306e\u6e1b\u5c11\u306b\u52b9\u679c\u7684\u3067\u3042\u308a\u3001\u8102\u80aa\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30a2\u30c7\u30a3\u30dd\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u6539\u5584\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u809d\u81d3\u3084\u7b4b\u8089\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u304c\u5f37\u5316\u3055\u308c\u3001\u8840\u7cd6\u5236\u5fa1\u304c\u6539\u5584\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.2 \u809d\u81d3\u3067\u306e\u7cd6\u4ee3\u8b1d\u6539\u5584<\/strong><\/h3>\n\n\n\n<p>\u809d\u81d3\u3067\u306e\u7cd6\u65b0\u751f\u304c\u6291\u5236\u3055\u308c\u3001\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u304c\u8efd\u6e1b\u3055\u308c\u307e\u3059\u3002GIP\u4f5c\u7528\u306f\u809d\u81d3\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u3001\u7cd6\u4ee3\u8b1d\u306e\u52b9\u7387\u5316\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.3 \u7b4b\u8089\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u5897\u52a0<\/strong><\/h3>\n\n\n\n<p>\u7b4b\u8089\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u8f38\u9001\u4f53\uff08GLUT4\uff09\u306e\u767a\u73fe\u304c\u5897\u52a0\u3057\u3001\u672b\u68a2\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u6d88\u8cbb\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3092\u6291\u3048\u308b\u3068\u540c\u6642\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u30de\u30f3\u30b8\u30e3\u30ed\u3068\u5f93\u6765GLP-1\u4f5c\u52d5\u85ac\u306e\u6bd4\u8f03<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u5f93\u6765GLP-1\u4f5c\u52d5\u85ac\uff08\u4f8b\uff1a\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3001\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\uff09\u3068\u306e\u6bd4\u8f03\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u70b9\u304c\u7279\u5fb4\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u9805\u76ee<\/strong><\/td><td><strong>\u30de\u30f3\u30b8\u30e3\u30ed<\/strong><\/td><td><strong>\u5f93\u6765GLP-1\u4f5c\u52d5\u85ac<\/strong><\/td><\/tr><tr><td>\u4f5c\u7528<\/td><td>GIP+GLP-1\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528<\/td><td>GLP-1\u5358\u72ec\u4f5c\u7528<\/td><\/tr><tr><td>\u4f53\u91cd\u6e1b\u5c11<\/td><td>\u7d0410\u301c15kg<\/td><td>\u7d046\u301c10kg<\/td><\/tr><tr><td>HbA1c\u6539\u5584<\/td><td>\u7d042.0\uff05<\/td><td>\u7d041.5\uff05<\/td><\/tr><tr><td>\u6d88\u5316\u5668\u75c7\u72b6<\/td><td>\u4e2d\u7b49\u5ea6\u3001\u6295\u4e0e\u958b\u59cb\u6642\u306b\u591a\u3044<\/td><td>\u4e2d\u7b49\u5ea6\u3001\u540c\u69d8<\/td><\/tr><tr><td>\u6295\u4e0e\u983b\u5ea6<\/td><td>\u90311\u56de\u76ae\u4e0b\u6ce8\u5c04<\/td><td>\u90311\u56de\u301c\u6bce\u65e5\u76ae\u4e0b\u6ce8\u5c04<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u8868\u304b\u3089\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u5f93\u6765\u85ac\u3088\u308a\u3082<strong>\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u52b9\u679c\u304c\u9ad8\u3044<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u526f\u4f5c\u7528\u3068\u6ce8\u610f\u70b9<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u4e00\u822c\u7684\u306b\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u3092\u793a\u3057\u307e\u3059\u304c\u3001\u4ee5\u4e0b\u306e\u526f\u4f5c\u7528\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5410\u304d\u6c17\u30fb\u5614\u5410<br><\/li>\n\n\n\n<li>\u4e0b\u75e2\u30fb\u4fbf\u79d8<br><\/li>\n\n\n\n<li>\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc<br><\/li>\n\n\n\n<li>\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u306f\u5358\u72ec\u6295\u4e0e\u3067\u306f\u4f4e\u3044\u304c\u3001SU\u85ac\u4f75\u7528\u6642\u306f\u6ce8\u610f<br><\/li>\n<\/ul>\n\n\n\n<p>\u307e\u305f\u3001\u81b5\u708e\u3084\u80c6\u56a2\u75be\u60a3\u306e\u65e2\u5f80\u304c\u3042\u308b\u60a3\u8005\u306b\u306f\u614e\u91cd\u6295\u4e0e\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u6295\u4e0e\u6226\u7565\u3068\u6cbb\u7642\u7d99\u7d9a\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u90311\u56de\u6295\u4e0e\u306e\u305f\u3081\u3001\u7d99\u7d9a\u6027\u304c\u9ad8\u3044\u70b9\u304c\u7279\u5fb4\u3067\u3059\u3002\u521d\u671f\u6295\u4e0e\u91cf\u3092\u4f4e\u304f\u8a2d\u5b9a\u3057\u30012\u301c4\u9031\u9593\u3054\u3068\u306b\u5897\u91cf\u3059\u308b<strong>\u6f38\u5897\u6295\u4e0e\u6cd5<\/strong>\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u6d88\u5316\u5668\u75c7\u72b6\u306e\u767a\u73fe\u3092\u6291\u3048\u3064\u3064\u3001\u52b9\u679c\u7684\u306a\u4f53\u91cd\u6e1b\u5c11\u3092\u9054\u6210\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u4eca\u5f8c\u306e\u7814\u7a76\u52d5\u5411<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u307e\u3060\u65b0\u3057\u3044\u85ac\u5264\u3067\u3042\u308a\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c\u3068\u3057\u3066\u4ee5\u4e0b\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u975e\u7cd6\u5c3f\u75c5\u80a5\u6e80\u60a3\u8005\u3078\u306e\u9577\u671f\u6e1b\u91cf\u52b9\u679c\u306e\u691c\u8a3c<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u4e88\u9632\u52b9\u679c\u306e\u78ba\u8a8d<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u4f75\u7528\u7642\u6cd5\u306b\u3088\u308b\u6e1b\u91cf\u52b9\u679c\u306e\u6700\u9069\u5316<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u6295\u4e0e\u6226\u7565\u306e\u78ba\u7acb<\/strong><strong><br><\/strong><\/li>\n<\/ol>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u3088\u308a\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u306a\u80a5\u6e80\u6cbb\u7642\u306e\u9078\u629e\u80a2\u3068\u3057\u3066\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u5730\u4f4d\u304c\u78ba\u7acb\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30de\u30f3\u30b8\u30e3\u30ed\u306fGIP\u3068GLP-1\u306e\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u306b\u3088\u308a\u3001<strong>\u4f53\u91cd\u6e1b\u5c11\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584<\/strong>\u306e\u4e21\u65b9\u3067\u512a\u308c\u305f\u52b9\u679c\u3092\u793a\u3059<br><\/li>\n\n\n\n<li>\u98df\u6b32\u6291\u5236\u3001\u809d\u81d3\u3068\u7b4b\u8089\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u6539\u5584\u306b\u3088\u308a\u3001\u8840\u7cd6\u7ba1\u7406\u306b\u3082\u5bc4\u4e0e<br><\/li>\n\n\n\n<li>\u5f93\u6765\u306eGLP-1\u4f5c\u52d5\u85ac\u3088\u308a\u9ad8\u3044\u6e1b\u91cf\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<br><\/li>\n\n\n\n<li>\u6d88\u5316\u5668\u75c7\u72b6\u306e\u7ba1\u7406\u3068\u6bb5\u968e\u7684\u5897\u91cf\u304c\u6cbb\u7642\u7d99\u7d9a\u306e\u30dd\u30a4\u30f3\u30c8<br><\/li>\n\n\n\n<li>\u9577\u671f\u5b89\u5168\u6027\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u52b9\u679c\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u4eca\u5f8c\u91cd\u8981<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f7f\u7528\u306b\u304a\u3051\u308b\u81e8\u5e8a\u4e0a\u306e\u6ce8\u610f\u70b9<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u9ad8\u3044\u6e1b\u91cf\u52b9\u679c\u3068\u8840\u7cd6\u6539\u5584\u52b9\u679c\u3092\u793a\u3059\u4e00\u65b9\u3067\u3001\u4f7f\u7528\u306b\u969b\u3057\u3066\u306f\u4ee5\u4e0b\u306e\u70b9\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.1 \u6d88\u5316\u5668\u75c7\u72b6\u306e\u30de\u30cd\u30b8\u30e1\u30f3\u30c8<\/strong><\/h3>\n\n\n\n<p>\u6700\u3082\u591a\u304f\u5831\u544a\u3055\u308c\u308b\u526f\u4f5c\u7528\u306f\u5410\u304d\u6c17\u3001\u4e0b\u75e2\u3001\u4fbf\u79d8\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u6295\u4e0e\u521d\u671f\u306b\u591a\u304f\u898b\u3089\u308c\u3001\u6bb5\u968e\u7684\u306b\u6295\u4e0e\u91cf\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u8efd\u6e1b\u53ef\u80fd\u3067\u3059\u3002\u307e\u305f\u3001\u98df\u4e8b\u91cf\u3092\u5c11\u3057\u305a\u3064\u6e1b\u3089\u3059\u300c\u6f38\u6e1b\u98df\u4e8b\u6cd5\u300d\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6d88\u5316\u5668\u75c7\u72b6\u306e\u767a\u73fe\u30ea\u30b9\u30af\u3092\u3055\u3089\u306b\u6291\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.2 \u4f75\u7528\u85ac\u306e\u6ce8\u610f<\/strong><\/h3>\n\n\n\n<p>SU\u85ac\uff08\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\uff09\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u306e\u4f75\u7528\u6642\u306f\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u305f\u3081\u3001\u4f75\u7528\u6642\u306b\u306f\u6295\u4e0e\u91cf\u8abf\u6574\u304c\u5fc5\u8981\u3067\u3059\u3002\u7279\u306b\u9ad8\u9f62\u8005\u3084\u814e\u6a5f\u80fd\u4f4e\u4e0b\u60a3\u8005\u3067\u306f\u614e\u91cd\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.3 \u9577\u671f\u6295\u4e0e\u306e\u5b89\u5168\u6027<\/strong><\/h3>\n\n\n\n<p>\u73fe\u6642\u70b9\u3067\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u6bd4\u8f03\u7684\u65b0\u3057\u3044\u85ac\u5264\u3067\u3042\u308a\u3001\u9577\u671f\u6295\u4e0e\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u7cfb\u30a4\u30d9\u30f3\u30c8\u3084\u81b5\u708e\u306e\u30ea\u30b9\u30af\u306b\u95a2\u3057\u3066\u306f\u3001\u5f15\u304d\u7d9a\u304d\u6ce8\u610f\u6df1\u3044\u89b3\u5bdf\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u5b9a\u671f\u7684\u306a\u8840\u6db2\u691c\u67fb\u3068\u81e8\u5e8a\u8a55\u4fa1\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u500b\u5225\u5316\u6cbb\u7642\u306e\u8996\u70b9<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u52b9\u679c\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u4f53\u91cd\u6e1b\u5c11\u306e\u5ea6\u5408\u3044\u3084\u526f\u4f5c\u7528\u306e\u51fa\u65b9\u306f\u5e74\u9f62\u3001\u6027\u5225\u3001\u57fa\u790e\u75be\u60a3\u3001\u751f\u6d3b\u7fd2\u6163\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u305f\u3081\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u500b\u5225\u5316\u6226\u7565\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BMI\u3084\u4f53\u8102\u80aa\u7387\u306b\u5fdc\u3058\u305f\u521d\u671f\u6295\u4e0e\u91cf\u8a2d\u5b9a<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u4f75\u7528\u85ac\u306e\u7a2e\u985e\u306b\u5fdc\u3058\u305f\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163\u6539\u5584\uff08\u98df\u4e8b\u30fb\u904b\u52d5\uff09\u3068\u306e\u4f75\u7528<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u4f53\u91cd\u5909\u5316\u3068\u8840\u7cd6\u7ba1\u7406\u306e\u5b9a\u671f\u7684\u306a\u8a55\u4fa1<\/strong><strong><br><\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u6700\u5927\u9650\u306e\u6cbb\u7642\u52b9\u679c\u3068\u5b89\u5168\u6027\u3092\u4e21\u7acb\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306fGLP-1\u5358\u72ec\u4f5c\u7528\u85ac\u3067\u306f\u9054\u6210\u56f0\u96e3\u3060\u3063\u305f\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u3092\u53ef\u80fd\u306b\u3059\u308b\u85ac\u5264\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306e\u8ab2\u984c\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u975e\u7cd6\u5c3f\u75c5\u80a5\u6e80\u60a3\u8005\u3078\u306e\u9577\u671f\u6e1b\u91cf\u52b9\u679c\u306e\u691c\u8a3c<br><\/li>\n\n\n\n<li>\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u52b9\u679c\u306e\u9577\u671f\u8a55\u4fa1<br><\/li>\n\n\n\n<li>\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u6700\u9069\u6295\u4e0e\u30b9\u30ad\u30fc\u30e0\u306e\u78ba\u7acb<br><\/li>\n\n\n\n<li>\u4ed6\u306e\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u30d7\u30ed\u30b0\u30e9\u30e0\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u52b9\u679c\u306e\u691c\u8a0e<br><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u80a5\u6e80\u6cbb\u7642\u3084\u7cd6\u5c3f\u75c5\u7ba1\u7406\u306b\u304a\u3051\u308b\u4e2d\u5fc3\u7684\u306a\u6cbb\u7642\u85ac\u306e\u4e00\u3064\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30de\u30f3\u30b8\u30e3\u30ed\u306f<strong>GIP\u3068GLP-1\u306e\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528<\/strong>\u306b\u3088\u308a\u3001\u4f53\u91cd\u6e1b\u5c11\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u4e21\u65b9\u3067\u9ad8\u3044\u52b9\u679c\u3092\u793a\u3059\u3002<br><\/li>\n\n\n\n<li>\u98df\u6b32\u6291\u5236\u3001\u809d\u81d3\u30fb\u7b4b\u8089\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u6539\u5584\u306b\u3088\u308a\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3082\u540c\u6642\u306b\u6539\u5584\u3055\u308c\u308b\u3002<br><\/li>\n\n\n\n<li>\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u5f93\u6765GLP-1\u4f5c\u52d5\u85ac\u3088\u308a\u3082\u512a\u308c\u305f\u6e1b\u91cf\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<br><\/li>\n\n\n\n<li>\u6295\u4e0e\u521d\u671f\u306f\u526f\u4f5c\u7528\uff08\u5410\u304d\u6c17\u30fb\u4e0b\u75e2\uff09\u304c\u51fa\u3084\u3059\u3044\u305f\u3081\u3001\u6f38\u5897\u6295\u4e0e\u3067\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<br><\/li>\n\n\n\n<li>\u500b\u5225\u5316\u6cbb\u7642\u6226\u7565\u3068\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u306e\u4f75\u7528\u306b\u3088\u308a\u3001\u6700\u5927\u9650\u306e\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3002<br><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e\u30fb\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Frias JP, et al. &#8220;Efficacy and Safety of Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, in Patients with Type 2 Diabetes (SURPASS-1): A Randomized, Double-Blind, Phase 3 Trial.&#8221; <em>N Engl J Med.<\/em> 2021;385:503-515.<br><\/li>\n\n\n\n<li>Rosenstock J, et al. &#8220;Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2): A Randomized, Open-Label, Phase 3 Trial.&#8221; <em>Lancet.<\/em> 2022;399:39-50.<br><\/li>\n\n\n\n<li>Wilding JPH, et al. &#8220;Tirzepatide versus Placebo or Semaglutide for Weight Management.&#8221; <em>N Engl J Med.<\/em> 2021;384:989-1002.\u00a0<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u80a5\u6e80\u30842\u578b\u7cd6\u5c3f\u75c5\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u3001\u4f53\u91cd\u6e1b\u5c11\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6539\u5584\u306f\u6cbb\u7642\u306e\u91cd\u8981\u306a\u76ee\u6a19\u3067\u3059\u3002\u8fd1\u5e74\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u4e2d\u3067\u3082\u30de\u30f3\u30b8\u30e3\u30ed\uff08tirzepatide\uff09\u306f\u3001\u5f93\u6765\u306e\u5358\u4e00GLP-1\u4f5c\u52d5\u85ac\u3068\u306f\u7570\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u3001\u3088\u308a\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3068\u8840\u7cd6\u6539\u5584\u3092\u793a\u3059\u3053\u3068\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7a3f\u3067\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u6a5f\u5e8f\u3001\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u81e8\u5e8a\u30c7\u30fc\u30bf\u3001\u305d\u3057\u3066\u4ed6\u306eGLP-1\u4f5c\u52d5\u85ac\u3068\u306e\u6bd4\u8f03\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002 1. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u57fa\u790e\u77e5\u8b58 \u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u30da\u30d7\u30c1\u30c9\uff09\u3068GLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff09\u3092\u540c\u6642\u306b\u523a\u6fc0\u3059\u308b\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u85ac\u3067\u3059\u3002\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306fGLP-1\u53d7\u5bb9\u4f53\u306b\u7279\u5316\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306fGIP\u53d7\u5bb9\u4f53\u306b\u3082\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u306e\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u306b\u3088\u308a\u3001\u5f93\u6765\u85ac\u3088\u308a\u3082\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u5927\u304d\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 2. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u6a5f\u5e8f \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u306f\u4e3b\u306b\u4ee5\u4e0b\u306e3\u3064\u306e\u7d4c\u8def\u3067\u8aac\u660e\u3055\u308c\u307e\u3059\u3002 2.1 \u98df\u6b32\u4e2d\u67a2\u3078\u306e\u5f71\u97ff GLP-1\u53d7\u5bb9\u4f53\u523a\u6fc0\u306b\u3088\u308a\u3001\u8133\u306e\u6e80\u8179\u4e2d\u67a2\u306b\u4fe1\u53f7\u304c\u4f1d\u308f\u308a\u3001\u98df\u6b32\u304c\u6291\u5236\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306bGIP\u4f5c\u7528\u3082\u76f8\u4e57\u7684\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6442\u98df\u884c\u52d5\u306e\u6291\u5236\u304c\u5f37\u5316\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u81ea\u7136\u306a\u30ab\u30ed\u30ea\u30fc\u6442\u53d6\u306e\u6e1b\u5c11\u304c\u8d77\u3053\u308a\u3001\u4f53\u91cd\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 2.2 \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u4fc3\u9032 \u30de\u30f3\u30b8\u30e3\u30ed\u306f\u81b5\u03b2\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3066\u3001\u8840\u7cd6\u5024\u306b\u5fdc\u3058\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u7279\u306b\u98df\u5f8c\u9ad8\u8840\u7cd6\u6642\u306b\u9855\u8457\u306a\u52b9\u679c\u3092\u793a\u3059\u305f\u3081\u3001\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u306f\u6bd4\u8f03\u7684\u4f4e\u304f\u6291\u3048\u3089\u308c\u307e\u3059\u3002 2.3 \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6539\u5584 GIP\u4f5c\u7528\u306b\u3088\u3063\u3066\u672b\u68a2\u7d44\u7e54\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u6539\u5584\u3055\u308c\u307e\u3059\u3002\u8102\u80aa\u7d44\u7e54\u3084\u7b4b\u8089\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304c\u5897\u52a0\u3057\u3001\u8840\u7cd6\u306e\u6052\u5e38\u6027\u304c\u6539\u5584\u3055\u308c\u308b\u3068\u540c\u6642\u306b\u3001\u809d\u81d3\u3067\u306e\u7cd6\u65b0\u751f\u6291\u5236\u3082\u8d77\u3053\u308a\u307e\u3059\u3002\u3053\u306e\u7d50\u679c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u8efd\u6e1b\u3055\u308c\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u75c5\u614b\u6539\u5584\u306b\u3082\u5bc4\u4e0e\u3057\u307e\u3059\u3002 3. \u81e8\u5e8a\u8a66\u9a13\u3067\u306e\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c \u30de\u30f3\u30b8\u30e3\u30ed\u306f\u81e8\u5e8a\u8a66\u9a13\u3067\u3001\u5f93\u6765\u306eGLP-1\u4f5c\u52d5\u85ac\u3088\u308a\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4ee3\u8868\u7684\u306a\u8a66\u9a13\u306fSURPASS\u30b7\u30ea\u30fc\u30ba\u3067\u3059\u3002 \u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u3082\u975e\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u3082\u9ad8\u3044\u6e1b\u91cf\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 4. \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0 \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306b\u76f4\u63a5\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002 4.1 \u8102\u80aa\u7d44\u7e54\u306e\u6539\u5584 \u30de\u30f3\u30b8\u30e3\u30ed\u306f\u5185\u81d3\u8102\u80aa\u306e\u6e1b\u5c11\u306b\u52b9\u679c\u7684\u3067\u3042\u308a\u3001\u8102\u80aa\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30a2\u30c7\u30a3\u30dd\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u6539\u5584\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u809d\u81d3\u3084\u7b4b\u8089\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u304c\u5f37\u5316\u3055\u308c\u3001\u8840\u7cd6\u5236\u5fa1\u304c\u6539\u5584\u3057\u307e\u3059\u3002 4.2 \u809d\u81d3\u3067\u306e\u7cd6\u4ee3\u8b1d\u6539\u5584 \u809d\u81d3\u3067\u306e\u7cd6\u65b0\u751f\u304c\u6291\u5236\u3055\u308c\u3001\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u304c\u8efd\u6e1b\u3055\u308c\u307e\u3059\u3002GIP\u4f5c\u7528\u306f\u809d\u81d3\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u3001\u7cd6\u4ee3\u8b1d\u306e\u52b9\u7387\u5316\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002 4.3 \u7b4b\u8089\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u5897\u52a0 \u7b4b\u8089\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u8f38\u9001\u4f53\uff08GLUT4\uff09\u306e\u767a\u73fe\u304c\u5897\u52a0\u3057\u3001\u672b\u68a2\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u6d88\u8cbb\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3092\u6291\u3048\u308b\u3068\u540c\u6642\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3057\u307e\u3059\u3002 5. 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