{"id":1265,"date":"2025-09-26T03:15:54","date_gmt":"2025-09-26T03:15:54","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/diet\/?p=1265"},"modified":"2025-09-26T03:15:55","modified_gmt":"2025-09-26T03:15:55","slug":"manjaro-glp1-gip-dual-agonist","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/diet\/manjaro-glp1-gip-dual-agonist\/","title":{"rendered":"GLP-1\u3068GIP\u306e\u4e8c\u91cd\u4f5c\u7528\u3092\u6301\u3064\u30de\u30f3\u30b8\u30e3\u30ed\u304c\u6ce8\u76ee\u3055\u308c\u308b\u7406\u7531"},"content":{"rendered":"\n<p>\u8fd1\u5e74\u3001\u80a5\u6e80\u30842\u578b\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001GLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff09\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u5e83\u304f\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001**\u30de\u30f3\u30b8\u30e3\u30ed\uff08Tirzepatide\uff09**\u306f\u3001GLP-1\u53d7\u5bb9\u4f53\u3060\u3051\u3067\u306a\u304f\u3001GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\uff09\u53d7\u5bb9\u4f53\u306b\u3082\u4f5c\u7528\u3059\u308b\u300c\u4e8c\u91cd\u4f5c\u7528\u85ac\u300d\u3068\u3057\u3066\u3001\u5f93\u6765\u306e\u6cbb\u7642\u85ac\u3068\u7570\u306a\u308b\u9769\u65b0\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u7a3f\u3067\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u6a5f\u5e8f\u3001\u81e8\u5e8a\u30c7\u30fc\u30bf\u3001\u6e1b\u91cf\u52b9\u679c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u4ed6\u306e\u85ac\u5264\u3068\u306e\u9055\u3044\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u30de\u30f3\u30b8\u30e3\u30ed\u3068\u306f\u4f55\u304b<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001\u7c73\u56fd\u304a\u3088\u3073\u65e5\u672c\u3067\u627f\u8a8d\u3055\u308c\u305f<strong>GIP\/GLP-1\u30c7\u30e5\u30a2\u30eb\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac<\/strong>\u3067\u3059\u3002\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u98df\u6b32\u6291\u5236\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u306b\u9650\u5b9a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3055\u3089\u306bGIP\u53d7\u5bb9\u4f53\u3078\u306e\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u3067\u3001\u7cd6\u4ee3\u8b1d\u3068\u4f53\u91cd\u7ba1\u7406\u306e\u4e21\u65b9\u306b\u9ad8\u3044\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GLP-1\u4f5c\u7528:<\/strong> \u98df\u6b32\u6291\u5236\u3001\u80c3\u6392\u51fa\u9045\u5ef6\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032<br><\/li>\n\n\n\n<li><strong>GIP\u4f5c\u7528:<\/strong> \u8102\u80aa\u7d44\u7e54\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u6539\u5584\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584<br><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u4e8c\u91cd\u4f5c\u7528\u306b\u3088\u308a\u3001\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3088\u308a\u3082\u5f37\u529b\u306a<strong>\u6e1b\u91cf\u52b9\u679c<\/strong>\u3068<strong>\u8840\u7cd6\u6539\u5584\u52b9\u679c<\/strong>\u304c\u5f97\u3089\u308c\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f<strong>GLP-1\u53d7\u5bb9\u4f53\u3068GIP\u53d7\u5bb9\u4f53\u306e\u4e21\u65b9\u3092\u6d3b\u6027\u5316<\/strong>\u3059\u308b\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u4f5c\u7528\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u98df\u6b32\u6291\u5236:<\/strong> \u8133\u306e\u6e80\u8179\u4e2d\u67a2\u306b\u4f5c\u7528\u3057\u3001\u98df\u6b32\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u80c3\u6392\u51fa\u9045\u5ef6:<\/strong> \u98df\u7269\u306e\u80c3\u304b\u3089\u8178\u3078\u306e\u79fb\u52d5\u3092\u9045\u304f\u3057\u3001\u6e80\u8179\u611f\u3092\u6301\u7d9a\u3055\u305b\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032:<\/strong> \u98df\u5f8c\u8840\u7cd6\u4e0a\u6607\u306b\u5fdc\u3058\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u5897\u52a0\u3055\u305b\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u8102\u80aa\u7d44\u7e54\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u6539\u5584:<\/strong> GIP\u4f5c\u7528\u306b\u3088\u308a\u8102\u80aa\u9178\u9178\u5316\u3092\u4fc3\u9032\u3057\u3001\u4f53\u8102\u80aa\u6e1b\u5c11\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<br><\/li>\n<\/ol>\n\n\n\n<p>\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001<strong>\u4e8c\u91cd\u4f5c\u7528\u306b\u3088\u308b\u30b7\u30ca\u30b8\u30fc\u52b9\u679c<\/strong>\u3067\u3088\u308a\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u7387\u3068\u8840\u7cd6\u6539\u5584\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u81e8\u5e8a\u8a66\u9a13\u3067\u793a\u3055\u308c\u305f\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u52b9\u679c<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.1 SURPASS\u30b7\u30ea\u30fc\u30ba<\/strong><\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u81e8\u5e8a\u30c7\u30fc\u30bf\u306e\u4e2d\u5fc3\u306fSURPASS\u8a66\u9a13\u30b7\u30ea\u30fc\u30ba\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SURPASS-1:<\/strong> 2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3092\u5b9f\u65bd\u3002<br>\n<ul class=\"wp-block-list\">\n<li>\u7d50\u679c: 26\u9031\u9593\u3067\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11\u306f\u7d047\u301c10\uff05\u3001HbA1c\u4f4e\u4e0b\u306f1.8\u301c2.0\uff05\u3002<br><\/li>\n\n\n\n<li>\u51fa\u5178: Frias JP et al., NEJM 2021<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SURPASS-2:<\/strong> \u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08GLP-1\u4f5c\u52d5\u85ac\uff09\u3068\u306e\u6bd4\u8f03\u8a66\u9a13\u3002<br>\n<ul class=\"wp-block-list\">\n<li>\u7d50\u679c: \u30de\u30f3\u30b8\u30e3\u30ed\u7fa4\u306f\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u7fa4\u3088\u308a\u3082\u6709\u610f\u306b\u4f53\u91cd\u6e1b\u5c11\u304c\u5927\u304d\u304f\u3001\u8840\u7cd6\u6539\u5584\u52b9\u679c\u3082\u540c\u7b49\u4ee5\u4e0a\u3002<br><\/li>\n\n\n\n<li>[\u51fa\u5178: Rosenstock J et al., Lancet 2022]<br><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SURPASS-5:<\/strong> \u30a4\u30f3\u30b9\u30ea\u30f3\u4f75\u7528\u60a3\u8005\u306b\u304a\u3051\u308b\u52b9\u679c\u691c\u8a3c\u3002<br>\n<ul class=\"wp-block-list\">\n<li>\u7d50\u679c: \u30de\u30f3\u30b8\u30e3\u30ed\u8ffd\u52a0\u3067\u4f53\u91cd\u6e1b\u5c11\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u4f7f\u7528\u91cf\u6e1b\u5c11\u3001HbA1c\u6539\u5584\u3092\u78ba\u8a8d\u3002<br><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.2 \u6e1b\u91cf\u52b9\u679c\u306e\u7279\u5fb4<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11\u7387\u306f<strong>\u6700\u592720\uff05\u8fd1\u304f<\/strong>\u306b\u9054\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u3001\u5f93\u6765\u306eGLP-1\u4f5c\u52d5\u85ac\u3088\u308a\u512a\u308c\u305f\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u7279\u306b<strong>\u5185\u81d3\u8102\u80aa\u306e\u6e1b\u5c11<\/strong>\u306b\u9855\u8457\u306a\u52b9\u679c\u304c\u898b\u3089\u308c\u3001\u7cd6\u5c3f\u75c5\u4e88\u9632\u3084\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306fGIP\u53d7\u5bb9\u4f53\u4f5c\u7528\u306b\u3088\u308a\u3001<strong>\u809d\u81d3\u30fb\u7b4b\u8089\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u5411\u4e0a<\/strong>\u3092\u4fc3\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u809d\u81d3:<\/strong> \u30b0\u30eb\u30b3\u30fc\u30b9\u7523\u751f\u6291\u5236\u306b\u3088\u308a\u7a7a\u8179\u6642\u8840\u7cd6\u3092\u6539\u5584<br><\/li>\n\n\n\n<li><strong>\u7b4b\u8089:<\/strong> \u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u5897\u52a0\u306b\u3088\u308a\u98df\u5f8c\u8840\u7cd6\u306e\u4e0a\u6607\u3092\u6291\u5236<br><\/li>\n\n\n\n<li><strong>\u8102\u80aa\u7d44\u7e54:<\/strong> \u8102\u80aa\u9178\u9178\u5316\u4fc3\u9032\u3068\u8102\u80aa\u84c4\u7a4d\u6291\u5236<br><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u5358\u306b\u8840\u7cd6\u3092\u4e0b\u3052\u308b\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u305d\u306e\u3082\u306e\u306e\u6539\u5584<\/strong>\u304c\u671f\u5f85\u3067\u304d\u3001\u9577\u671f\u7684\u306a\u7cd6\u4ee3\u8b1d\u6539\u5584\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/32942486_s-1.webp\" alt=\"\u533b\u7642\" class=\"wp-image-1185\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/32942486_s-1.webp 640w, https:\/\/www.hiro-clinic.or.jp\/diet\/wp-content\/uploads\/2025\/09\/32942486_s-1-300x200.webp 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u30de\u30f3\u30b8\u30e3\u30ed\u3068\u4ed6\u306eGLP-1\u4f5c\u52d5\u85ac\u306e\u9055\u3044<\/strong><\/h2>\n\n\n\n<p>\u5f93\u6765\u306eGLP-1\u4f5c\u52d5\u85ac\uff08\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306a\u3069\uff09\u3068\u306e\u6bd4\u8f03\u30dd\u30a4\u30f3\u30c8\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u9805\u76ee<\/strong><\/td><td><strong>\u5f93\u6765GLP-1\u4f5c\u52d5\u85ac<\/strong><\/td><td><strong>\u30de\u30f3\u30b8\u30e3\u30ed<\/strong><\/td><\/tr><tr><td>\u53d7\u5bb9\u4f53\u4f5c\u7528<\/td><td>GLP-1\u306e\u307f<\/td><td>GLP-1 + GIP<\/td><\/tr><tr><td>\u5e73\u5747\u4f53\u91cd\u6e1b\u5c11<\/td><td>5\u301c10\uff05<\/td><td>10\u301c20\uff05<\/td><\/tr><tr><td>HbA1c\u6539\u5584<\/td><td>1\u301c1.5\uff05<\/td><td>1.5\u301c2\uff05<\/td><\/tr><tr><td>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584<\/td><td>\u9650\u5b9a\u7684<\/td><td>\u809d\u30fb\u7b4b\u8089\u30fb\u8102\u80aa\u7d44\u7e54\u3067\u6539\u5584<\/td><\/tr><tr><td>\u6295\u4e0e\u983b\u5ea6<\/td><td>\u90311\u56de\u3001\u65e51\u56de\u306a\u3069<\/td><td>\u90311\u56de\u76ae\u4e0b\u6ce8\u5c04<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001<strong>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u4e8c\u91cd\u4f5c\u7528\u306b\u3088\u308b\u30b7\u30ca\u30b8\u30fc\u52b9\u679c<\/strong>\u3067\u3001\u5f93\u6765\u85ac\u3088\u308a\u3082\u9ad8\u3044\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u526f\u4f5c\u7528\u3068\u7ba1\u7406\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.1 \u6d88\u5316\u5668\u75c7\u72b6<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5410\u304d\u6c17\u3001\u4e0b\u75e2\u3001\u4fbf\u79d8\u304c\u4e3b\u306a\u526f\u4f5c\u7528<br><\/li>\n\n\n\n<li>\u6295\u4e0e\u521d\u671f\u306b\u591a\u304f\u767a\u73fe\u3057\u3001<strong>\u6f38\u5897\u6295\u4e0e<\/strong>\u3067\u8efd\u6e1b\u53ef\u80fd<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.2 \u4f4e\u8840\u7cd6\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SU\u85ac\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u306e\u4f75\u7528\u3067\u30ea\u30b9\u30af\u5897<br><\/li>\n\n\n\n<li>\u9ad8\u9f62\u8005\u3084\u814e\u6a5f\u80fd\u4f4e\u4e0b\u60a3\u8005\u3067\u306f\u614e\u91cd\u306a\u6295\u4e0e\u304c\u5fc5\u8981<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.3 \u9577\u671f\u5b89\u5168\u6027<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u73fe\u5728\u306e\u3068\u3053\u308d\u5927\u304d\u306a\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u81b5\u708e\u30ea\u30b9\u30af\u3084\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u3064\u3044\u3066\u306f\u5f15\u304d\u7d9a\u304d\u76e3\u8996\u304c\u5fc5\u8981\u3067\u3059\u3002<br><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u30de\u30f3\u30b8\u30e3\u30ed\u6cbb\u7642\u306e\u500b\u5225\u5316\u6226\u7565<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BMI\u3084\u4f53\u8102\u80aa\u7387\u306b\u5fdc\u3058\u305f\u521d\u671f\u6295\u4e0e\u91cf\u8a2d\u5b9a<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u65e2\u5b58\u85ac\u3068\u306e\u4f75\u7528\u72b6\u6cc1\u306e\u78ba\u8a8d<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u98df\u4e8b\u30fb\u904b\u52d5\u306a\u3069\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u4f75\u7528<\/strong><strong><br><\/strong><\/li>\n\n\n\n<li><strong>\u5b9a\u671f\u7684\u306a\u4f53\u91cd\u30fb\u8840\u7cd6\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong><strong><br><\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u5b89\u5168\u304b\u3064\u6700\u5927\u9650\u306e\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30de\u30f3\u30b8\u30e3\u30ed\u306fGLP-1\u3068GIP\u306e\u4e8c\u91cd\u4f5c\u7528\u306b\u3088\u308a\u3001<strong>\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584<\/strong>\u3092\u540c\u6642\u306b\u5b9f\u73fe<br><\/li>\n\n\n\n<li>SURPASS\u30b7\u30ea\u30fc\u30ba\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u3001\u5f93\u6765GLP-1\u4f5c\u52d5\u85ac\u3088\u308a\u512a\u308c\u305f\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<br><\/li>\n\n\n\n<li>\u6295\u4e0e\u521d\u671f\u306e\u526f\u4f5c\u7528\u7ba1\u7406\u3068\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u306e\u4f75\u7528\u304c\u3001\u6cbb\u7642\u6210\u529f\u306e\u9375<br><\/li>\n\n\n\n<li>\u4eca\u5f8c\u306e\u9577\u671f\u8a66\u9a13\u3067\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u3084\u80a5\u6e80\u6cbb\u7642\u3078\u306e\u6709\u52b9\u6027\u304c\u3055\u3089\u306b\u691c\u8a3c\u3055\u308c\u308b<br><\/li>\n<\/ul>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001<strong>\u80a5\u6e80\u30fb\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u304a\u3051\u308b\u6b21\u4e16\u4ee3\u85ac\u5264<\/strong>\u3068\u3057\u3066\u3001\u307e\u3059\u307e\u3059\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u30de\u30f3\u30b8\u30e3\u30ed\u6cbb\u7642\u306e\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u65e2\u5b58\u306eGLP-1\u4f5c\u52d5\u85ac\u3068\u306f\u7570\u306a\u308b<strong>GIP\u3068\u306e\u4e8c\u91cd\u4f5c\u7528<\/strong>\u3092\u6301\u3064\u70b9\u304c\u6700\u5927\u306e\u7279\u5fb4\u3067\u3042\u308a\u3001\u4eca\u5f8c\u306e\u80a5\u6e80\u6cbb\u7642\u30fb\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u5206\u91ce\u3067\u3055\u3089\u306a\u308b\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u4ee5\u4e0b\u306e\u70b9\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u52b9\u679c\u306e\u691c\u8a3c<\/strong><strong><br><\/strong> \u4e00\u90e8\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u4f4e\u6e1b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30f3\u30b8\u30e3\u30ed\u306b\u304a\u3044\u3066\u3082\u3001\u4f53\u91cd\u6e1b\u5c11\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306b\u3088\u308a\u3001\u9577\u671f\u7684\u306b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u73fe\u5728\u8907\u6570\u306e\u9577\u671f\u8ffd\u8de1\u8a66\u9a13\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u80a5\u6e80\u5358\u72ec\u3078\u306e\u9069\u5fdc\u62e1\u5927<\/strong><strong><br><\/strong> \u73fe\u5728\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u4e3b\u306b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u3067\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5c06\u6765\u7684\u306b\u306f<strong>\u7cd6\u5c3f\u75c5\u3092\u4f34\u308f\u306a\u3044\u80a5\u6e80\u60a3\u8005\u3078\u306e\u9069\u5fdc<\/strong>\u3082\u8996\u91ce\u306b\u5165\u3063\u3066\u3044\u307e\u3059\u3002\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u9ad8\u304f\u3001BMI\u6539\u5584\u3084\u751f\u6d3b\u7fd2\u6163\u75c5\u4e88\u9632\u306b\u6709\u52b9\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<br><\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u533b\u7642\u3078\u306e\u8ca2\u732e<\/strong><strong><br><\/strong> \u6295\u4e0e\u91cf\u3084\u4f75\u7528\u85ac\u306e\u8abf\u6574\u3001\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u4f75\u7528\u306b\u3088\u308a\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u6700\u9069\u5316\u3055\u308c\u305f\u6cbb\u7642\u6226\u7565\u304c\u53ef\u80fd\u3067\u3059\u3002\u526f\u4f5c\u7528\u306e\u767a\u73fe\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u306a\u304c\u3089\u3001\u6700\u5927\u9650\u306e\u52b9\u679c\u3092\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<br><\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u52a0\u3048\u3066GIP\u53d7\u5bb9\u4f53\u4f5c\u7528\u3092\u6301\u3064<strong>\u9769\u65b0\u7684\u306a\u30c7\u30e5\u30a2\u30eb\u4f5c\u7528\u85ac<\/strong>\u3067\u3059\u3002SURPASS\u30b7\u30ea\u30fc\u30ba\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u793a\u3055\u308c\u305f\u4f53\u91cd\u6e1b\u5c11\u7387\u3084HbA1c\u6539\u5584\u306f\u3001\u5f93\u6765\u85ac\u3088\u308a\u3082\u512a\u308c\u305f\u6210\u7e3e\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c<\/strong>\uff08\u5e73\u574710\u301c20\uff05\uff09<br><\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584<\/strong>\uff08\u809d\u30fb\u7b4b\u8089\u30fb\u8102\u80aa\u7d44\u7e54\u3067\u4f5c\u7528\uff09<br><\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3068\u306e\u76f8\u4e57\u52b9\u679c<\/strong><strong><br><\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u80a5\u6e80\u30fb\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u304a\u3051\u308b\u6b21\u4e16\u4ee3\u306e\u9078\u629e\u80a2\u3068\u3057\u3066\u3001\u533b\u7642\u73fe\u5834\u3067\u306e\u5c0e\u5165\u304c\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u4eca\u5f8c\u3082\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u52b9\u679c\u306e\u691c\u8a3c\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u3088\u308a\u591a\u304f\u306e\u60a3\u8005\u306b\u5bfe\u3057\u3066\u9069\u5207\u306b\u4f7f\u7528\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e\u30fb\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Frias JP, et al. <em>Tirzepatide versus Placebo in Type 2 Diabetes.<\/em> NEJM. 2021;385:503\u2013515. <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2107519\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2107519<\/a><br><\/li>\n\n\n\n<li>Rosenstock J, et al. <em>SURPASS-2: Tirzepatide vs Semaglutide in Type 2 Diabetes.<\/em> Lancet. 2022;399:39\u201350. <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)02207-6\/fulltext\">https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)02207-6\/fulltext<\/a><br><\/li>\n\n\n\n<li>Gallwitz B. <em>Incretin-Based Therapies for Type 2 Diabetes: GLP-1\/GIP Dual Agonists.<\/em> Diabetes Obes Metab. 2022;24:147\u2013159. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/dom.14568\">https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/dom.14568<\/a><br><\/li>\n\n\n\n<li>Frias JP, et al. <em>Tirzepatide as a dual GIP and GLP-1 receptor agonist.<\/em> Diabetes Obes Metab. 2021;23:2699\u20132708. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/dom.14509\">https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/dom.14509<\/a><br><\/li>\n\n\n\n<li>Jastreboff AM, et al. <em>The Future of Obesity Treatment with Dual GLP-1\/GIP Agonists.<\/em> Nat Rev Endocrinol. 2022;18:73\u201384.<a href=\"https:\/\/www.nature.com\/articles\/s41574-021-00568-8\"> https:\/\/www.nature.com\/articles\/s41574-021-00568-8<br><\/a><\/li>\n<\/ol>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u5e74\u3001\u80a5\u6e80\u30842\u578b\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001GLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff09\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u5e83\u304f\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001**\u30de\u30f3\u30b8\u30e3\u30ed\uff08Tirzepatide\uff09**\u306f\u3001GLP-1\u53d7\u5bb9\u4f53\u3060\u3051\u3067\u306a\u304f\u3001GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\uff09\u53d7\u5bb9\u4f53\u306b\u3082\u4f5c\u7528\u3059\u308b\u300c\u4e8c\u91cd\u4f5c\u7528\u85ac\u300d\u3068\u3057\u3066\u3001\u5f93\u6765\u306e\u6cbb\u7642\u85ac\u3068\u7570\u306a\u308b\u9769\u65b0\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u7a3f\u3067\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u6a5f\u5e8f\u3001\u81e8\u5e8a\u30c7\u30fc\u30bf\u3001\u6e1b\u91cf\u52b9\u679c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u4ed6\u306e\u85ac\u5264\u3068\u306e\u9055\u3044\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002 1. \u30de\u30f3\u30b8\u30e3\u30ed\u3068\u306f\u4f55\u304b \u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001\u7c73\u56fd\u304a\u3088\u3073\u65e5\u672c\u3067\u627f\u8a8d\u3055\u308c\u305fGIP\/GLP-1\u30c7\u30e5\u30a2\u30eb\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u3059\u3002\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u98df\u6b32\u6291\u5236\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u306b\u9650\u5b9a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3055\u3089\u306bGIP\u53d7\u5bb9\u4f53\u3078\u306e\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u3067\u3001\u7cd6\u4ee3\u8b1d\u3068\u4f53\u91cd\u7ba1\u7406\u306e\u4e21\u65b9\u306b\u9ad8\u3044\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002 \u3053\u306e\u4e8c\u91cd\u4f5c\u7528\u306b\u3088\u308a\u3001\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3088\u308a\u3082\u5f37\u529b\u306a\u6e1b\u91cf\u52b9\u679c\u3068\u8840\u7cd6\u6539\u5584\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002 2. \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4f5c\u7528\u6a5f\u5e8f \u30de\u30f3\u30b8\u30e3\u30ed\u306fGLP-1\u53d7\u5bb9\u4f53\u3068GIP\u53d7\u5bb9\u4f53\u306e\u4e21\u65b9\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u4f5c\u7528\u3092\u793a\u3057\u307e\u3059\u3002 \u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u4e8c\u91cd\u4f5c\u7528\u306b\u3088\u308b\u30b7\u30ca\u30b8\u30fc\u52b9\u679c\u3067\u3088\u308a\u9ad8\u3044\u4f53\u91cd\u6e1b\u5c11\u7387\u3068\u8840\u7cd6\u6539\u5584\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002 3. \u81e8\u5e8a\u8a66\u9a13\u3067\u793a\u3055\u308c\u305f\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u52b9\u679c 3.1 SURPASS\u30b7\u30ea\u30fc\u30ba \u30de\u30f3\u30b8\u30e3\u30ed\u306e\u81e8\u5e8a\u30c7\u30fc\u30bf\u306e\u4e2d\u5fc3\u306fSURPASS\u8a66\u9a13\u30b7\u30ea\u30fc\u30ba\u3067\u3059\u3002 3.2 \u6e1b\u91cf\u52b9\u679c\u306e\u7279\u5fb4 4. \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u30e1\u30ab\u30cb\u30ba\u30e0 \u30de\u30f3\u30b8\u30e3\u30ed\u306fGIP\u53d7\u5bb9\u4f53\u4f5c\u7528\u306b\u3088\u308a\u3001\u809d\u81d3\u30fb\u7b4b\u8089\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u5411\u4e0a\u3092\u4fc3\u3057\u307e\u3059\u3002 \u3053\u308c\u306b\u3088\u308a\u3001\u5358\u306b\u8840\u7cd6\u3092\u4e0b\u3052\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u305d\u306e\u3082\u306e\u306e\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u3001\u9577\u671f\u7684\u306a\u7cd6\u4ee3\u8b1d\u6539\u5584\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002 5. \u30de\u30f3\u30b8\u30e3\u30ed\u3068\u4ed6\u306eGLP-1\u4f5c\u52d5\u85ac\u306e\u9055\u3044 \u5f93\u6765\u306eGLP-1\u4f5c\u52d5\u85ac\uff08\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306a\u3069\uff09\u3068\u306e\u6bd4\u8f03\u30dd\u30a4\u30f3\u30c8\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002 \u9805\u76ee \u5f93\u6765GLP-1\u4f5c\u52d5\u85ac \u30de\u30f3\u30b8\u30e3\u30ed \u53d7\u5bb9\u4f53\u4f5c\u7528 GLP-1\u306e\u307f GLP-1 + GIP \u5e73\u5747\u4f53\u91cd\u6e1b\u5c11 5\u301c10\uff05 10\u301c20\uff05 HbA1c\u6539\u5584 1\u301c1.5\uff05 1.5\u301c2\uff05 \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584 \u9650\u5b9a\u7684 \u809d\u30fb\u7b4b\u8089\u30fb\u8102\u80aa\u7d44\u7e54\u3067\u6539\u5584 \u6295\u4e0e\u983b\u5ea6 \u90311\u56de\u3001\u65e51\u56de\u306a\u3069 \u90311\u56de\u76ae\u4e0b\u6ce8\u5c04 \u3053\u306e\u3088\u3046\u306b\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u4e8c\u91cd\u4f5c\u7528\u306b\u3088\u308b\u30b7\u30ca\u30b8\u30fc\u52b9\u679c\u3067\u3001\u5f93\u6765\u85ac\u3088\u308a\u3082\u9ad8\u3044\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002 6. \u526f\u4f5c\u7528\u3068\u7ba1\u7406\u65b9\u6cd5 6.1 \u6d88\u5316\u5668\u75c7\u72b6 6.2 \u4f4e\u8840\u7cd6\u30ea\u30b9\u30af 6.3 \u9577\u671f\u5b89\u5168\u6027 7. \u30de\u30f3\u30b8\u30e3\u30ed\u6cbb\u7642\u306e\u500b\u5225\u5316\u6226\u7565 \u3053\u308c\u3089\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u5b89\u5168\u304b\u3064\u6700\u5927\u9650\u306e\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002 [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":1266,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[171],"tags":[37,14,172,157],"class_list":["post-1265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-171","tag-37","tag-14","tag-172","tag-157"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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