{"id":190,"date":"2025-06-09T06:55:01","date_gmt":"2025-06-09T06:55:01","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/diet\/?p=190"},"modified":"2025-08-12T08:27:42","modified_gmt":"2025-08-12T08:27:42","slug":"nutrition-for-skin-health-aging-acne-atopic-psoriasis","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/diet\/nutrition-for-skin-health-aging-acne-atopic-psoriasis\/","title":{"rendered":"\u98df\u3079\u3082\u306e\u3068\u808c\u306e\u6df1\u3044\u95a2\u4fc2\u2500\u2500\u79d1\u5b66\u304c\u793a\u3059\u3001\u8001\u5316\u30fb\u708e\u75c7\u30fb\u76ae\u819a\u75be\u60a3\u3078\u306e\u6804\u990a\u7684\u30a2\u30d7\u30ed\u30fc\u30c1"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u808c\u3068\u98df\u4e8b\u306e\u95a2\u4fc2\uff5c\u79d1\u5b66\u306b\u57fa\u3065\u304f\u5b9f\u8df5\u30ac\u30a4\u30c9\uff08\u3059\u3050\u306b\u4f7f\u3048\u308b\u307e\u3068\u3081\uff09<\/h2>\n\n\n\n<!-- Skin Health Table with Minimalist Icons -->\n<style>\n  .skin-health-icons {\n    width: 100%;\n    border-collapse: collapse;\n    margin: 1.5em 0;\n    font-family: sans-serif;\n    font-size: 1rem;\n  }\n\n  .skin-health-icons th,\n  .skin-health-icons td {\n    border: 1px solid #ccc;\n    padding: 1em;\n    vertical-align: top;\n  }\n\n  .skin-health-icons th {\n    background-color: #f8f8f8;\n    font-weight: bold;\n    text-align: left;\n  }\n\n  .skin-health-icons td strong {\n    color: #2a7a66;\n  }\n\n  .skin-health-icons td {\n    line-height: 1.6;\n  }\n<\/style>\n\n<table class=\"skin-health-icons\">\n  <thead>\n    <tr>\n      <th>\u304a\u60a9\u307f<\/th>\n      <th>\u79d1\u5b66\uff0b\u5b9f\u8df5\u30a2\u30c9\u30d0\u30a4\u30b9<\/th>\n    <\/tr>\n  <\/thead>\n  <tbody>\n    <tr>\n      <td><strong>\u7d2b\u5916\u7dda\u306b\u3088\u308b\u30b7\u30df\u30fb\u30b7\u30ef\u30fb\u305f\u308b\u307f<\/strong><\/td>\n      <td>\n        \ud83e\uded2 <strong>\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3092\u4f7f\u3046\uff1a<\/strong> \u5149\u8001\u5316\u3092\u9632\u3050\u53ef\u80fd\u6027\u3042\u308a\u3002<br>\n        \ud83e\udd55 <strong>\u6fc3\u3044\u8272\u306e\u91ce\u83dc\u30fb\u30ca\u30c3\u30c4\u3092\u6442\u308b\uff1a<\/strong> \u30ab\u30ed\u30c6\u30f3\u3084\u30d3\u30bf\u30df\u30f3E\u3067\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3002\n      <\/td>\n    <\/tr>\n    <tr>\n      <td><strong>\u30cb\u30ad\u30d3\uff08\u601d\u6625\u671f\u30fb\u5927\u4eba\uff09<\/strong><\/td>\n      <td>\n        \ud83d\udeab <strong>\u7518\u3044\u3082\u306e\u3084\u767d\u7c73\u30fb\u767d\u30d1\u30f3\u3092\u63a7\u3048\u308b\uff1a<\/strong> \u8840\u7cd6\u5024\u304c\u4e0a\u304c\u308b\u3068\u76ae\u8102\u304c\u904e\u5270\u306b\u51fa\u3084\u3059\u304f\u306a\u308b\u3002<br>\n        \ud83d\udc1f <strong>\u9752\u9b5a\u30fb\u30ca\u30c3\u30c4\u30fb\u4e9c\u9ebb\u4ec1\u6cb9\u3092\u6442\u308b\uff1a<\/strong> \u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u304c\u708e\u75c7\u3092\u6291\u3048\u308b\u3002\n      <\/td>\n    <\/tr>\n    <tr>\n      <td><strong>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\uff08\u4e7e\u71e5\u30fb\u304b\u3086\u307f\uff09<\/strong><\/td>\n      <td>\n        \ud83c\udf76 <strong>\u767a\u9175\u98df\u54c1\u3067\u8178\u3092\u6574\u3048\u308b\uff1a<\/strong> \u7d0d\u8c46\u30fb\u5473\u564c\u30fb\u30e8\u30fc\u30b0\u30eb\u30c8\u306a\u3069\u3067\u514d\u75ab\u306e\u5b89\u5b9a\u3092\u652f\u3048\u308b\u3002<br>\n        \ud83e\uddea <strong>\u6804\u990a\u691c\u67fb\u3092\u53d7\u3051\u308b\uff1a<\/strong> \u4e9c\u925b\u30fb\u30d3\u30bf\u30df\u30f3D\/E\u306e\u4e0d\u8db3\u3092\u78ba\u8a8d\u3057\u3001\u5fc5\u8981\u306a\u3089\u88dc\u3046\u3002\n      <\/td>\n    <\/tr>\n    <tr>\n      <td><strong>\u4e7e\u766c\uff08\u8d64\u304f\u786c\u3044\u76ae\u819a\u30c8\u30e9\u30d6\u30eb\uff09<\/strong><\/td>\n      <td>\n        \u2600\ufe0f <strong>\u65e5\u5149\uff0b\u9752\u9b5a\u30fb\u6d77\u85fb\uff1a<\/strong> \u30d3\u30bf\u30df\u30f3D\u3068EPA\u3067\u76ae\u819a\u708e\u306e\u6291\u5236\u3092\u30b5\u30dd\u30fc\u30c8\u3002<br>\n        \ud83e\uddef <strong>\u63da\u3052\u7269\u3084\u52a0\u5de5\u8089\u3092\u63a7\u3048\u308b\uff1a<\/strong> \u708e\u75c7\u306e\u60aa\u5316\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3002\n      <\/td>\n    <\/tr>\n    <tr>\n      <td><strong>\u808c\u306e\u8001\u5316\u5168\u822c\uff08\u7d30\u80de\u30ec\u30d9\u30eb\uff09<\/strong><\/td>\n      <td>\n        \ud83e\udd57 <strong>\u690d\u7269\u4e2d\u5fc3\u306e\u98df\u4e8b\u3092\u610f\u8b58\uff1a<\/strong> \u91ce\u83dc\u3084\u679c\u7269\u304c\u7d30\u80de\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u3002<br>\n        \ud83d\udd25 <strong>\u7126\u3052\u30fb\u63da\u3052\u7269\u3092\u63a7\u3048\u308b\uff1a<\/strong> AGEs\u3068\u3044\u3046\u6210\u5206\u304c\u808c\u306e\u5f3e\u529b\u3092\u640d\u306a\u3046\u3002\n      <\/td>\n    <\/tr>\n    <tr>\n      <td><strong>\u9854\u306e\u30b7\u30ef\u30fb\u305f\u308b\u307f<\/strong><\/td>\n      <td>\n        \ud83c\udf53 <strong>\u679c\u7269\u30fb\u91ce\u83dc\u3092\u6bce\u65e5\u6442\u308b\uff1a<\/strong> \u30b7\u30ef\u306e\u5c11\u306a\u3055\u3068\u95a2\u9023\u304c\u3042\u308b\u3068\u7814\u7a76\u3067\u78ba\u8a8d\u3002<br>\n        \ud83d\udeab <strong>\u30b9\u30ca\u30c3\u30af\u3084\u52a0\u5de5\u98df\u54c1\u306f\u63a7\u3048\u3081\u306b\uff1a<\/strong> \u30d9\u30ea\u30fc\u30fb\u30c8\u30de\u30c8\u30fb\u67d1\u6a58\u985e\u3092\u7fd2\u6163\u306b\u3002\n      <\/td>\n    <\/tr>\n  <\/tbody>\n<\/table>\n\n\n\n<h2 class=\"wp-block-heading\">\u5e8f\u7ae0\uff1a\u808c\u3068\u98df\u4e8b\u3001\u60f3\u50cf\u4ee5\u4e0a\u306e\u6df1\u3044\u3064\u306a\u304c\u308a<\/h2>\n\n\n\n<p>\u304b\u3064\u3066\u3001\u300c\u7f8e\u3057\u3044\u808c\u306f\u751f\u307e\u308c\u3064\u304d\u300d\u3068\u4fe1\u3058\u3089\u308c\u3066\u3044\u305f\u6642\u4ee3\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u73fe\u4ee3\u3001\u76ae\u819a\u79d1\u5b66\uff08dermatology\uff09\u306f\u5927\u304d\u304f\u5909\u308f\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u306e\u6bce\u65e5\u306e\u98df\u4e8b\u304c\u3001\u898b\u305f\u76ee\u306e\u82e5\u3005\u3057\u3055\u3060\u3051\u3067\u306a\u304f\u3001\u76ae\u819a\u306e\u69cb\u9020\u3084\u6a5f\u80fd\u306b\u307e\u3067\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u3001\u79d1\u5b66\u306e\u529b\u306b\u3088\u3063\u3066\u6b21\u7b2c\u306b\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u76ae\u819a\u306e\u8001\u5316\u306b\u306f\u5927\u304d\u304f\u5206\u3051\u3066\u4e8c\u3064\u306e\u8981\u56e0\u304c\u3042\u308a\u307e\u3059\u3002\u4e00\u3064\u306f\u5e74\u9f62\u306b\u4f34\u3046\u300c\u5185\u56e0\u6027\u8001\u5316\uff08intrinsic aging\uff09\u300d\u3001\u3082\u3046\u4e00\u3064\u306f\u7d2b\u5916\u7dda\u3084\u5927\u6c17\u6c5a\u67d3\u306a\u3069\u74b0\u5883\u8981\u56e0\u306b\u3088\u308b\u300c\u5916\u56e0\u6027\u8001\u5316\uff08extrinsic aging\uff09\u300d\u3001\u7279\u306b\u300c\u5149\u8001\u5316\uff08photoaging\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u73fe\u8c61\u3067\u3059\u3002\u3044\u305a\u308c\u3082\u81ea\u7136\u306a\u73fe\u8c61\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u98df\u751f\u6d3b\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u5de5\u592b\u306b\u3088\u3063\u3066\u3001\u305d\u306e\u9032\u884c\u3092\u5927\u304d\u304f\u9045\u3089\u305b\u305f\u308a\u3001\u75c7\u72b6\u3092\u7de9\u548c\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u6587\u7ae0\u3067\u306f\u3001\u76ae\u819a\u306e\u8001\u5316\u3068\u4e09\u5927\u76ae\u819a\u75be\u60a3\uff08\u30cb\u30ad\u30d3\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3001\u4e7e\u766c\uff09\u306b\u7126\u70b9\u3092\u5f53\u3066\u3001\u6804\u990a\u3068\u306e\u95a2\u9023\u3092\u6700\u65b0\u306e\u81e8\u5e8a\u8a66\u9a13\u3084\u75ab\u5b66\u7814\u7a76\u3001\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89b3\u70b9\u304b\u3089\u7269\u8a9e\u306e\u3088\u3046\u306b\u4e01\u5be7\u306b\u7d10\u89e3\u3044\u3066\u3044\u304d\u307e\u3059\u3002\u79d1\u5b66\u7684\u6839\u62e0\u3092\u4e00\u3064\u3072\u3068\u3064\u78ba\u8a8d\u3057\u306a\u304c\u3089\u3001\u79c1\u305f\u3061\u306e\u98df\u4e8b\u304c\u3044\u304b\u306b\u76ae\u819a\u306e\u904b\u547d\u3092\u5de6\u53f3\u3057\u3066\u3044\u308b\u304b\u3092\u3001\u6df1\u304f\u63a2\u3063\u3066\u307e\u3044\u308a\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c\u4e00\u7ae0\uff1a\u5149\u8001\u5316\u3068\u6804\u990a\u306e\u77e5\u3089\u308c\u3056\u308b\u76f8\u4e92\u4f5c\u7528<\/h2>\n\n\n\n<p>\u5916\u3067\u904e\u3054\u3059\u6642\u9593\u306e\u9577\u3044\u65b9\u3001\u65e5\u5dee\u3057\u304c\u5f37\u3044\u5730\u57df\u306b\u4f4f\u3080\u65b9\u306b\u3068\u3063\u3066\u3001\u300c\u5149\u8001\u5316\u300d\u306f\u6c7a\u3057\u3066\u4ed6\u4eba\u4e8b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7d2b\u5916\u7dda\uff08ultraviolet, UV\uff09\u3001\u7279\u306bUVA\u304a\u3088\u3073UVB\u304c\u76ae\u819a\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306f\u3001\u5358\u306a\u308b\u65e5\u713c\u3051\u3067\u306f\u306a\u304f\u3001\u76ae\u819a\u306e\u5f3e\u529b\u4f4e\u4e0b\u3084\u30b7\u30ef\u3001\u30b7\u30df\u3001\u76ae\u819a\u304c\u3093\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306b\u307e\u3067\u53ca\u3073\u307e\u3059\u3002\u3067\u306f\u3001\u3053\u3046\u3057\u305f\u5909\u5316\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u79c1\u305f\u3061\u306f\u98df\u4e8b\u3067\u3069\u306e\u3088\u3046\u306a\u5bfe\u7b56\u304c\u53d6\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u03b2-\u30ab\u30ed\u30c6\u30f3\u3068\u30d3\u30bf\u30df\u30f3E\u306e\u5149\u9632\u5fa1\u52b9\u679c<\/h3>\n\n\n\n<p>\u307e\u305a\u6ce8\u76ee\u3057\u305f\u3044\u306e\u304c\u3001\u03b2-\u30ab\u30ed\u30c6\u30f3\uff08provitamin A carotenoid\uff09\u3067\u3059\u3002\u5f37\u529b\u306a\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3064\u3053\u306e\u6210\u5206\u306f\u300150\u6b73\u4ee5\u4e0a\u306e\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306b\u304a\u3044\u3066\u300130mg\/\u65e5\u309290\u65e5\u9593\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u9854\u306e\u30b7\u30ef\u306e\u6539\u5584\u3084\u76ae\u819a\u306e\u5f3e\u529b\u5411\u4e0a\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u2160\u578b\u30d7\u30ed\u30b3\u30e9\u30fc\u30b2\u30f3\uff08type I procollagen\uff09\u306emRNA\u306e\u5897\u52a0\u3001\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u751f\u3058\u308bDNA\u640d\u50b7\u30de\u30fc\u30ab\u30fc\uff08\u30c1\u30df\u30f3\u4e8c\u91cf\u4f53\u30848-\u30d2\u30c9\u30ed\u30ad\u30b7-2\u2019-\u30c7\u30aa\u30ad\u30b7\u30b0\u30a2\u30ce\u30b7\u30f3\uff09\u306e\u6e1b\u5c11\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3068\u3053\u308d\u304c\u3001\u540c\u3058\u8a66\u9a13\u306790mg\/\u65e5\u3068\u3044\u3046\u9ad8\u7528\u91cf\u3092\u6442\u53d6\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u7d2b\u5916\u7dda\u306b\u5bfe\u3059\u308b\u76ae\u819a\u306e\u8010\u6027\uff08\u6700\u5c0f\u7d05\u6591\u91cf\uff09\u304c\u3080\u3057\u308d\u4f4e\u4e0b\u3059\u308b\u3068\u3044\u3046\u9006\u8aac\u7684\u7d50\u679c\u304c\u5f97\u3089\u308c\uff08P=0.025\uff09\u3001\u904e\u5270\u6442\u53d6\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u5927\u304c\u61f8\u5ff5\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u03b2-\u30ab\u30ed\u30c6\u30f3\u306b335mg\u306e\u30d3\u30bf\u30df\u30f3E\uff08RRR-\u03b1-\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u3092\u52a0\u3048\u305f\u4f75\u7528\u7642\u6cd5\u3067\u306f\u3001\u5358\u72ec\u6442\u53d6\u3068\u540c\u69d8\u306b8\u9031\u9593\u3067\u7d2b\u5916\u7dda\u306b\u3088\u308b\u7d05\u6591\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\uff08P&lt;0.01\uff09\u3002\u306a\u304a\u300112\u9031\u76ee\u306b\u306f\u4e21\u7fa4\u3068\u3082\u624b\u306e\u3072\u3089\u3084\u9854\u306b\u76ae\u819a\u306e\u9ec4\u8272\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u03b2-\u30ab\u30ed\u30c6\u30f3\u306e\u76ae\u819a\u3078\u306e\u84c4\u7a4d\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b3\u30e9\u30fc\u30b2\u30f3\u30da\u30d7\u30c1\u30c9\u306e\u7d4c\u53e3\u6442\u53d6\u3068\u808c\u306e\u5f3e\u529b<\/h3>\n\n\n\n<p>\u4e00\u65b9\u3001\u808c\u306e\u69cb\u9020\u7684\u306a\u6539\u5584\u306b\u5bc4\u4e0e\u3059\u308b\u6210\u5206\u3068\u3057\u3066\u3001\u7d4c\u53e3\u6442\u53d6\u578b\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u30da\u30d7\u30c1\u30c9\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u300235\u301c55\u6b73\u306e\u5973\u602769\u540d\u3092\u5bfe\u8c61\u306b\u884c\u308f\u308c\u305f\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u306f\u30012.5g\u307e\u305f\u306f5g\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u30928\u9031\u9593\u6bce\u65e5\u6442\u53d6\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3044\u3066\u3001\u7279\u306b50\u6b73\u4ee5\u4e0a\u306e\u53c2\u52a0\u8005\u3067\u76ae\u819a\u306e\u5f3e\u529b\u6027\u304c\u6709\u610f\u306b\u5411\u4e0a\u3057\u307e\u3057\u305f\uff08P&lt;0.05\uff09\u3002\u526f\u4f5c\u7528\u306f\u5831\u544a\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u5b89\u5168\u6027\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5730\u4e2d\u6d77\u5f0f\u306e\u77e5\u6075\uff1a\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3068\u4e00\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178<\/h3>\n\n\n\n<p>\u9577\u671f\u7684\u306a\u98df\u7fd2\u6163\u3068\u808c\u8001\u5316\u3068\u306e\u95a2\u9023\u6027\u3082\u3001SU.VI.MAX\u7814\u7a76\uff08\u30d5\u30e9\u30f3\u30b9\uff09\u306b\u3088\u3063\u3066\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u300245\u301c60\u6b73\u306e\u7537\u59732,900\u4eba\u4ee5\u4e0a\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3053\u306e\u89e3\u6790\u3067\u306f\u3001\u7279\u306b\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u690d\u7269\u7531\u6765\u306e\u4e00\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\uff08monounsaturated fatty acids, MUFAs\uff09\u306e\u6442\u53d6\u304c\u3001\u7537\u6027\u306b\u304a\u3051\u308b\u5149\u8001\u5316\u306e\u91cd\u75c7\u5ea6\u3068\u9006\u76f8\u95a2\u3092\u793a\u3057\u307e\u3057\u305f\uff08\u8abf\u6574\u30aa\u30c3\u30ba\u6bd4\uff1d0.76\u300195%\u4fe1\u983c\u533a\u9593\uff1a0.57\u20131.00\u3001P=0.03\uff09\u3002\u5973\u6027\u306b\u304a\u3044\u3066\u3082\u3001\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306e\u6442\u53d6\u306b\u9650\u308c\u3070\u6709\u610f\u306a\u4fdd\u8b77\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08AOR = 0.69\u3001P = 0.03\uff09\u3002<\/p>\n\n\n\n<p>\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306b\u542b\u307e\u308c\u308b\u30aa\u30ec\u30a4\u30f3\u9178\u306f\u9178\u5316\u306b\u5f37\u304f\u3001\u52a0\u3048\u3066\u30b9\u30ad\u30f3\u30b1\u30a2\u6210\u5206\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3084\u30b9\u30af\u30a2\u30ec\u30f3\u3082\u8c4a\u5bcc\u3067\u3001\u3053\u308c\u3089\u304c\u6297\u9178\u5316\u9632\u5fa1\u3092\u5f37\u5316\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6297\u9178\u5316\u80fd\u529b\u3068\u52a0\u9f62\u306e\u95a2\u4fc2\uff1a15\u5e74\u306e\u8ffd\u8de1\u8abf\u67fb<\/h3>\n\n\n\n<p>\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306e\u30ca\u30f3\u30d0\u30fc\u30fb\u30b9\u30ad\u30f3\u30ad\u30e3\u30f3\u30b5\u30fc\u4e88\u9632\u8a66\u9a13\u3067\u306f\u300145\u6b73\u4ee5\u4e0a\u306e\u6210\u4eba\u306b\u304a\u3044\u3066\u3001\u98df\u4e8b\u4e2d\u306e\u975e\u9175\u7d20\u6027\u6297\u9178\u5316\u80fd\u529b\uff08FRAP\u6cd5\u306b\u3088\u308b\u8a55\u4fa1\uff09\u304c\u9ad8\u3044\u4eba\u307b\u3069\u300115\u5e74\u5f8c\u306e\u76ae\u819a\u8001\u5316\u306e\u9032\u884c\u304c\u6291\u3048\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08P for trend = 0.037\uff09\u3002\u3053\u3053\u3067\u3082\u7279\u5b9a\u306e\u98df\u54c1\u3067\u306f\u306a\u304f\u3001\u300c\u98df\u4e8b\u5168\u4f53\u306e\u8cea\u300d\u304c\u9375\u3068\u306a\u3063\u3066\u3044\u308b\u70b9\u304c\u7279\u7b46\u306b\u5024\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c\u4e8c\u7ae0\uff1a\u30cb\u30ad\u30d3\u3068\u98df\u4e8b\u2014\u7cd6\u8cea\u3001\u8102\u80aa\u9178\u3001\u708e\u75c7\u306e\u4e09\u91cd\u594f<\/h2>\n\n\n\n<p>\u30cb\u30ad\u30d3\u306f\u3001\u601d\u6625\u671f\u306e\u901a\u904e\u5100\u793c\u3068\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u6210\u4eba\u306b\u306a\u3063\u3066\u304b\u3089\u3082\u60a9\u307e\u3055\u308c\u308b\u4eba\u306f\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u75be\u60a3\u306f\u3001\u76ae\u8102\u306e\u904e\u5270\u5206\u6ccc\u3001\u6bdb\u7a74\u306e\u89d2\u5316\u7570\u5e38\u3001\u76ae\u819a\u5e38\u5728\u83cc\uff08\u7279\u306bCutibacterium acnes\uff09\u306e\u5897\u6b96\u3001\u305d\u3057\u3066\u305d\u308c\u306b\u4f34\u3046\u708e\u75c7\u53cd\u5fdc\u3068\u3044\u3063\u305f\u8907\u6570\u306e\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u767a\u75c7\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u3046\u3057\u305f\u5185\u90e8\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u5916\u7684\u8981\u56e0\u3068\u3057\u3066\u3001\u98df\u4e8b\u5185\u5bb9\u306e\u91cd\u8981\u6027\u304c\u518d\u8a55\u4fa1\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u7cbe\u88fd\u7cd6\u8cea\u306e\u904e\u5270\u6442\u53d6\u3084\u30aa\u30e1\u30ac\u8102\u80aa\u9178\u306e\u6442\u53d6\u30d0\u30e9\u30f3\u30b9\u304c\u3001\u30cb\u30ad\u30d3\u306e\u767a\u75c7\u3084\u60aa\u5316\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u8a3c\u62e0\u304c\u6b21\u3005\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4e71\u9ad8\u4e0b\u304c\u76ae\u8102\u817a\u3092\u523a\u6fc0\u3059\u308b<\/h3>\n\n\n\n<p>\u305d\u306e\u6700\u524d\u7dda\u306b\u3042\u308b\u306e\u304c\u3001\u300c\u30b0\u30ea\u30bb\u30df\u30c3\u30af\u30fb\u30a4\u30f3\u30c7\u30c3\u30af\u30b9\uff08GI\uff09\u300d\u304a\u3088\u3073\u300c\u30b0\u30ea\u30bb\u30df\u30c3\u30af\u30fb\u30ed\u30fc\u30c9\uff08GL\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u6982\u5ff5\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3001\u98df\u54c1\u304c\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u306b\u3069\u308c\u307b\u3069\u6025\u6fc0\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u304b\u3092\u8868\u3059\u6307\u6a19\u3067\u3059\u3002\u8840\u7cd6\u5024\u304c\u6025\u4e0a\u6607\u3059\u308b\u3068\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u3044\u3046\u30db\u30eb\u30e2\u30f3\u304c\u5927\u91cf\u306b\u5206\u6ccc\u3055\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u76ae\u8102\u817a\u3092\u523a\u6fc0\u3057\u3001\u76ae\u8102\u306e\u904e\u5270\u5206\u6ccc\u3092\u5f15\u304d\u8d77\u3053\u3059\u539f\u56e0\u3068\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b12\u9031\u9593\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u306f\u3001\u4f4eGI\u306e\u98df\u4e8b\uff08\u5168\u7c92\u7a40\u7269\u3001\u91ce\u83dc\u3001\u679c\u7269\u4e2d\u5fc3\uff09\u3092\u6442\u53d6\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30cb\u30ad\u30d3\u306e\u75c5\u5909\u6570\u304c\u5e73\u574723.5\u500b\u6e1b\u5c11\uff08\u6a19\u6e96\u8aa4\u5dee3.9\uff09\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u9ad8GI\u306e\u98df\u4e8b\u3092\u7d9a\u3051\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f12\u500b\u306e\u6e1b\u5c11\u306b\u3068\u3069\u307e\u308a\u307e\u3057\u305f\uff08P = 0.03\uff09\u3002\u3055\u3089\u306b\u3001\u4f53\u91cd\uff08P &lt; 0.001\uff09\u3084BMI\uff08P = 0.001\uff09\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u5411\u4e0a\u3082\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u5225\u306e10\u9031\u9593\u306e\u8a66\u9a13\u3067\u306f\u3001\u4f4eGI\u7fa4\u3067\u708e\u75c7\u6027\u75c5\u5909\u304c70.9%\u3001\u975e\u708e\u75c7\u6027\u75c5\u5909\u304c27.6%\u6e1b\u5c11\uff08\u305d\u308c\u305e\u308cP &lt; 0.05\u3001P = 0.04\uff09\u3059\u308b\u7d50\u679c\u3068\u306a\u308a\u3001\u6bdb\u5305\u5185\u306e\u76ae\u8102\u817a\u306e\u7e2e\u5c0f\u304a\u3088\u3073\u708e\u75c7\u6027\u30de\u30fc\u30ab\u30fc\uff08IL-8\uff09\u3084\u8102\u8cea\u751f\u6210\u95a2\u9023\u907a\u4f1d\u5b50\uff08SREBP-1\uff09\u306e\u767a\u73fe\u4f4e\u4e0b\uff08P = 0.03\uff09\u3082\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5fc5\u9808\u8102\u80aa\u9178\u3068\u76ae\u819a\u306e\u708e\u75c7\u8abf\u7bc0<\/h3>\n\n\n\n<p>\u8102\u8cea\u306e\u7a2e\u985e\u3082\u307e\u305f\u3001\u30cb\u30ad\u30d3\u306e\u5f62\u6210\u306b\u95a2\u308f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\uff08EPA\u304a\u3088\u3073DHA\uff09\u3068\u03b3-\u30ea\u30ce\u30ec\u30f3\u9178\uff08GLA\uff09\u306e\u6442\u53d6\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3001\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u751f\u7406\u6d3b\u6027\u7269\u8cea\u306e\u524d\u99c6\u4f53\u3067\u3042\u308a\u3001\u904e\u5270\u306a\u76ae\u8102\u3084\u708e\u75c7\u3092\u6291\u3048\u308b\u50cd\u304d\u3092\u6301\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p>45\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f10\u9031\u9593\u306e\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3067\u306f\u30011,000mg\u306eEPA\u3068DHA\u3001\u307e\u305f\u306f400mg\u306eGLA\uff08\u30dc\u30e9\u30fc\u30b8\u30aa\u30a4\u30eb\u7531\u6765\uff09\u3092\u6442\u53d6\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u708e\u75c7\u6027\u30fb\u975e\u708e\u75c7\u6027\u3068\u3082\u306b\u30cb\u30ad\u30d3\u75c5\u5909\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\uff08P &lt; 0.05\uff09\u3001\u708e\u75c7\u95a2\u9023\u306e\u7d44\u7e54\u5b66\u7684\u30de\u30fc\u30ab\u30fc\u3082\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u5bfe\u7167\u7fa4\u3067\u306f\u3053\u306e\u3088\u3046\u306a\u6539\u5584\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u4f4eGI\u98df\uff0b\u6297\u708e\u75c7\u6027\u8102\u80aa\u9178\u3068\u3044\u3046\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u30cb\u30ad\u30d3\u306b\u60a9\u3080\u591a\u304f\u306e\u4eba\u3005\u306b\u3068\u3063\u3066\u3001\u5b89\u5168\u304b\u3064\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u6709\u671b\u306a\u4ecb\u5165\u6cd5\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u3068\u308a\u308f\u3051\u3001\u85ac\u5264\u3078\u306e\u8010\u6027\u3084\u526f\u4f5c\u7528\u306b\u61f8\u5ff5\u3092\u6301\u3064\u82e5\u5e74\u5c64\u306b\u3068\u3063\u3066\u3001\u98df\u751f\u6d3b\u306e\u6539\u5584\u306f\u81ea\u3089\u306e\u624b\u3067\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u9078\u629e\u80a2\u3068\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c\u4e09\u7ae0\uff1a\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306b\u304a\u3051\u308b\u6804\u990a\u3068\u514d\u75ab\u306e\u63a5\u70b9<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u2014 \u5fae\u91cf\u5143\u7d20\u3001\u30d3\u30bf\u30df\u30f3\u3001\u8178\u5185\u7d30\u83cc\u306e\u4e09\u4f4d\u4e00\u4f53 \u2014<\/sup><\/p>\n\n\n\n<p>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u2015\u2015\u305d\u308c\u306f\u3001\u304b\u3086\u307f\u3068\u4e7e\u71e5\u304c\u3064\u304d\u307e\u3068\u3046\u76ae\u819a\u306e\u75c5\u3002\u3068\u308a\u308f\u3051\u5b50\u3069\u3082\u306b\u591a\u304f\u3001\u30a2\u30e1\u30ea\u30ab\u3067\u306f9\u301c18\uff05\u306e\u5c0f\u5150\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3001\u65e5\u672c\u3067\u3082\u540c\u69d8\u306b\u9ad8\u3044\u7f79\u60a3\u7387\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u75be\u60a3\u306f\u5358\u306a\u308b\u76ae\u819a\u306e\u554f\u984c\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u4f53\u8cea\u3001\u5598\u606f\u3001\u9f3b\u708e\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306a\u3069\u306e\u5168\u8eab\u7684\u306a\u75c7\u72b6\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3067\u306f\u306a\u305c\u3001\u76ae\u819a\u3068\u3044\u3046\u4e00\u679a\u306e\u819c\u304c\u3001\u3053\u308c\u307b\u3069\u591a\u304f\u306e\u514d\u75ab\u7684\u6df7\u4e71\u3092\u53cd\u6620\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u305d\u3057\u3066\u3001\u305d\u3053\u306b\u300c\u6804\u990a\u300d\u3068\u3044\u3046\u8eab\u8fd1\u306a\u8981\u56e0\u304c\u3069\u306e\u3088\u3046\u306b\u4ecb\u5165\u3067\u304d\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e9c\u925b\uff1a\u76ae\u819a\u4fee\u5fa9\u3068\u514d\u75ab\u306e\u5fc5\u9808\u30df\u30cd\u30e9\u30eb<\/h3>\n\n\n\n<p>\u307e\u305a\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001\u300c\u4e9c\u925b\uff08Zinc\uff09\u300d\u3068\u3044\u3046\u5fae\u91cf\u5143\u7d20\u3067\u3059\u3002\u4e9c\u925b\u306f\u3001\u76ae\u819a\u306e\u4fee\u5fa9\u3084\u514d\u75ab\u7cfb\u306e\u5236\u5fa1\u306b\u6b20\u304b\u305b\u306a\u3044\u5f79\u5272\u3092\u679c\u305f\u3059\u91d1\u5c5e\u30a4\u30aa\u30f3\u3067\u3001\u7279\u306b\u89d2\u8cea\u7d30\u80de\uff08\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\uff09\u306e\u5206\u88c2\u3084\u5206\u5316\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001AD\u60a3\u8005\u306e\u8d64\u8840\u7403\u5185\u306e\u4e9c\u925b\u6fc3\u5ea6\u304c\u5065\u5eb7\u306a\u5bfe\u7167\u7fa4\u3088\u308a\u6709\u610f\u306b\u4f4e\u304f\uff08P &lt; 0.001\uff09\u3001\u3055\u3089\u306b\u305d\u306e\u6fc3\u5ea6\u304c\u75be\u60a3\u306e\u91cd\u75c7\u5ea6\u3068\u5f37\u304f\u9006\u76f8\u95a2\u3057\u3066\u3044\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u76f8\u95a2\u4fc2\u6570r = \u22120.791, P &lt; 0.001\uff09\u3002\u8208\u5473\u6df1\u3044\u306e\u306f\u3001\u8840\u6e05\u4e2d\u306e\u4e9c\u925b\u6fc3\u5ea6\u3067\u306f\u306a\u304f\u3001\u8d64\u8840\u7403\u3084\u6bdb\u9aea\u3068\u3044\u3063\u305f\u300c\u9577\u671f\u7684\u306a\u6804\u990a\u72b6\u614b\u306e\u6307\u6a19\u300d\u304c\u3088\u308a\u91cd\u8981\u3067\u3042\u308b\u3068\u3044\u3046\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u767a\u898b\u306b\u57fa\u3065\u304d\u3001\u4f4e\u4e9c\u925b\u72b6\u614b\u306b\u3042\u308b41\u4eba\u306e\u5c0f\u5150\u306b\u5bfe\u3057\u30018\u9031\u9593\u306b\u308f\u305f\u308a1\u65e512mg\u306e\u9178\u5316\u4e9c\u925b\u3092\u88dc\u7d66\u3057\u305f\u3068\u3053\u308d\u3001\u6e7f\u75b9\u306e\u7bc4\u56f2\u3068\u91cd\u75c7\u5ea6\uff08EASI\u30b9\u30b3\u30a2\uff09\u3001\u7d4c\u76ae\u7684\u6c34\u5206\u84b8\u6563\u91cf\uff08TEWL\uff09\u3001\u304b\u3086\u307f\u306e\u4e3b\u89b3\u8a55\u4fa1\u30b9\u30b3\u30a2\u306e\u3059\u3079\u3066\u306b\u304a\u3044\u3066\u3001\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u6709\u610f\u306a\u6539\u5584\u304c\u898b\u3089\u308c\u307e\u3057\u305f\uff08P = 0.015\u301c&lt;0.001\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30d3\u30bf\u30df\u30f3D\u3068E\uff1a\u6297\u708e\u75c7\u30d3\u30bf\u30df\u30f3\u306e\u76f8\u4e57\u52b9\u679c<\/h3>\n\n\n\n<p>\u6b21\u306b\u91cd\u8981\u306a\u306e\u306f\u3001\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u2015\u2015\u7279\u306b\u30d3\u30bf\u30df\u30f3D\uff08D3\uff09\u3068\u30d3\u30bf\u30df\u30f3E\uff08\u03b1-\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u306e\u5f79\u5272\u3067\u3059\u3002\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u76ae\u819a\u306b\u5b58\u5728\u3059\u308b\u53d7\u5bb9\u4f53\u3092\u901a\u3058\u3066\u514d\u75ab\u7d30\u80de\u306e\u904e\u5270\u53cd\u5fdc\u3092\u6291\u3048\u308b\u50cd\u304d\u3092\u6301\u3061\u3001\u307e\u305f\u76ae\u819a\u30d0\u30ea\u30a2\u306e\u5f62\u6210\u306b\u3082\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001\u30d3\u30bf\u30df\u30f3E\u306f\u3001\u8102\u8cea\u904e\u9178\u5316\u3092\u9632\u3050\u6297\u9178\u5316\u7269\u8cea\u3068\u3057\u3066\u77e5\u3089\u308c\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u751f\u6210\u3092\u6291\u5236\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u4f5c\u7528\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u884c\u308f\u308c\u305f60\u65e5\u9593\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u9855\u8457\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d7\u30e9\u30bb\u30dc\u7fa4\uff1aSCORAD\u6307\u6570\uff08AD\u306e\u91cd\u75c7\u5ea6\u8a55\u4fa1\u6307\u6a19\uff09\u306e\u6539\u5584\u7387 28.9%<br><\/li>\n\n\n\n<li>\u30d3\u30bf\u30df\u30f3D3\u7fa4\uff081600 IU\/\u65e5\uff09\uff1a\u6539\u5584\u7387 34.8%<br><\/li>\n\n\n\n<li>\u30d3\u30bf\u30df\u30f3E\u7fa4\uff08600 IU\/\u65e5\uff09\uff1a\u6539\u5584\u7387 35.7%<br><\/li>\n\n\n\n<li>\u4e21\u8005\u4f75\u7528\u7fa4\uff1a\u6539\u5584\u7387 64.3%\uff08P = 0.004\uff09<br><\/li>\n<\/ul>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u30d3\u30bf\u30df\u30f3E\u306e\u8840\u4e2d\u6fc3\u5ea6\uff08\u03b1-\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u3068SCORAD\u306e\u9593\u306b\u8ca0\u306e\u76f8\u95a2\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\uff08r = \u22120.33, P = 0.025\uff09\u3001\u3059\u306a\u308f\u3061\u3001\u4f53\u5185\u306e\u30d3\u30bf\u30df\u30f3E\u304c\u591a\u3044\u307b\u3069\u75c7\u72b6\u304c\u8efd\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30d3\u30bf\u30df\u30f3B6\uff1a\u52b9\u679c\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u4f8b\u5916<\/h3>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u5168\u3066\u306e\u30d3\u30bf\u30df\u30f3\u304c\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u300248\u4eba\u306e\u5c0f\u5150AD\u60a3\u8005\u3092\u5bfe\u8c61\u306b50mg\/\u65e5\u306e\u30d3\u30bf\u30df\u30f3B6\uff08\u30d4\u30ea\u30c9\u30ad\u30b7\u30f3\uff09\u3092\u6295\u4e0e\u3057\u305f\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3067\u306f\u3001\u304b\u3086\u307f\u3084\u767a\u8d64\u3001\u7761\u7720\u969c\u5bb3\u3068\u3044\u3063\u305f\u4e3b\u75c7\u72b6\u306b\u304a\u3044\u3066\u6709\u610f\u306a\u6539\u5584\u306f\u898b\u3089\u308c\u305a\u3001\u305d\u306e\u6709\u52b9\u6027\u306f\u5426\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8178\u5185\u74b0\u5883\u3068\u76ae\u819a\u306e\u201c\u5bfe\u8a71\u201d\uff1a\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u53ef\u80fd\u6027<\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\uff08microbiota\uff09\u3068\u76ae\u819a\u3068\u306e\u95a2\u9023\u304c\u6ce8\u76ee\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u8178\u5185\u3067\u767a\u751f\u3057\u305f\u514d\u75ab\u60c5\u5831\u304c\u3001\u76ae\u819a\u306b\u3082\u6ce2\u53ca\u3059\u308b\u300c\u8178-\u76ae\u819a\u8ef8\uff08gut-skin axis\uff09\u300d\u3068\u3044\u3046\u6982\u5ff5\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u4eee\u8aac\u3092\u88cf\u4ed8\u3051\u308b\u5f62\u3067\u3001206\u4eba\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u4e73\u5150\u306b\u5bfe\u3057\u3066\u3001\u7279\u5b9a\u306e\u30aa\u30ea\u30b4\u7cd6\uff08\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff09\u3092\u6dfb\u52a0\u3057\u305f\u30df\u30eb\u30af\u3092\u6295\u4e0e\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u751f\u5f8c6\u304b\u6708\u6642\u70b9\u3067AD\u3092\u767a\u75c7\u3057\u305f\u5272\u5408\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e23.1%\u306b\u5bfe\u3057\u3001\u4ecb\u5165\u7fa4\u3067\u306f9.8%\u306b\u3068\u3069\u307e\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\u306f13.3%\u300195%\u4fe1\u983c\u533a\u9593\u306f5.4%\u301c20.2%\u3067\u3042\u308a\u3001\u7d71\u8a08\u7684\u306b\u3082\u81e8\u5e8a\u7684\u306b\u3082\u610f\u5473\u306e\u3042\u308b\u4e88\u9632\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c\u56db\u7ae0\uff1a\u4e7e\u766c\u3068\u4ee3\u8b1d\u30fb\u514d\u75ab\u30fb\u6804\u990a\u306e\u4ea4\u5dee\u70b9<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u2014 \u708e\u75c7\u3092\u93ae\u3081\u308b\u8102\u80aa\u9178\u3068\u30d3\u30bf\u30df\u30f3\u306e\u53ef\u80fd\u6027\u3092\u63a2\u308b \u2014<\/sup><\/p>\n\n\n\n<p>\u4e7e\u766c\uff08\u304b\u3093\u305b\u3093\uff09\u2015\u2015\u76ae\u819a\u304c\u8d64\u304f\u76db\u308a\u4e0a\u304c\u308a\u3001\u9280\u767d\u8272\u306e\u9c57\u5c51\uff08\u308a\u3093\u305b\u3064\uff09\u304c\u6d6e\u304b\u3076\u6162\u6027\u75be\u60a3\u3002\u3053\u306e\u75be\u60a3\u306f\u5358\u306a\u308b\u76ae\u819a\u306e\u7570\u5e38\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3080\u3057\u308d\u305d\u308c\u306f\u3001\u4f53\u5185\u306e\u514d\u75ab\u7cfb\u3068\u4ee3\u8b1d\u7cfb\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u751f\u3058\u308b\u300c\u5168\u8eab\u6027\u708e\u75c7\u75be\u60a3\u300d\u3068\u3057\u3066\u306e\u5074\u9762\u3092\u5f37\u304f\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e7e\u766c\u306e\u60a3\u8005\u3055\u3093\u306f\u3001\u540c\u6642\u306b\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8102\u8840\u75c7\u3001\u3055\u3089\u306b\u306f\u708e\u75c7\u6027\u8178\u75be\u60a3\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306a\u3069\u3092\u4f75\u767a\u3059\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u305d\u308c\u3086\u3048\u306b\u8fd1\u5e74\u3067\u306f\u300c\u4e7e\u766c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u300d\u3068\u3082\u547c\u3070\u308c\u308b\u65b0\u3057\u3044\u75c5\u614b\u6982\u5ff5\u304c\u63d0\u5531\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u80cc\u666f\u306e\u4e2d\u3067\u3001\u300c\u98df\u4e8b\u300d\u304c\u4e7e\u766c\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\u3001\u79d1\u5b66\u8005\u305f\u3061\u306f\u6ce8\u76ee\u3057\u306f\u3058\u3081\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30aa\u30e1\u30ac\u8102\u80aa\u9178\uff1a\u75c7\u72b6\u7de9\u548c\u306f\u3059\u308b\u304c\u3001\u6cbb\u7652\u306b\u306f\u81f3\u3089\u305a<\/h3>\n\n\n\n<p>\u4e7e\u766c\u306b\u5bfe\u3059\u308b\u6804\u990a\u4ecb\u5165\u3068\u3057\u3066\u6700\u3082\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u308b\u306e\u306f\u3001\u300c\u30aa\u30e1\u30ac\u8102\u80aa\u9178\uff08omega fatty acids\uff09\u300d\u306e\u52b9\u679c\u3067\u3059\u3002\u306a\u304b\u3067\u3082\u30aa\u30e1\u30ac-3\uff08n-3\uff09\u8102\u80aa\u9178\u2015\u2015EPA\uff08\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff09\u3084DHA\uff08\u30c9\u30b3\u30b5\u30d8\u30ad\u30b5\u30a8\u30f3\u9178\uff09\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6301\u3061\u3001\u514d\u75ab\u7d30\u80de\u306e\u66b4\u8d70\u3092\u93ae\u3081\u308b\u50cd\u304d\u304c\u3042\u308b\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b4\u304b\u6708\u9593\u306b\u53ca\u3076\u591a\u65bd\u8a2d\u5171\u540c\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u306f\u30011\u65e56g\u306e\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\u7fa4\u3068\u3001\u5bfe\u7167\u3068\u3057\u3066\u306e\u30aa\u30e1\u30ac-6\u8102\u80aa\u9178\u7fa4\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u4e21\u7fa4\u3068\u3082\u306b\u9c57\u5c51\u306e\u6e1b\u5c11\uff08P &lt; 0.01\uff09\u306f\u898b\u3089\u308c\u307e\u3057\u305f\u304c\u3001\u4e3b\u8981\u8a55\u4fa1\u6307\u6a19\u3067\u3042\u308bPASI\u30b9\u30b3\u30a2\uff08Psoriasis Area and Severity Index\uff09\u3084\u60a3\u8005\u306e\u4e3b\u89b3\u7684\u6e80\u8db3\u5ea6\u306b\u306f\u6709\u610f\u306a\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u7d30\u304b\u304f\u898b\u308b\u3068\u3001\u30aa\u30e1\u30ac-3\u7fa4\u3067\u306f\u76ae\u819a\u3078\u306e\u7d30\u80de\u6d78\u6f64\u306e\u6e1b\u5c11\uff08P &lt; 0.01\uff09\u3001\u30aa\u30e1\u30ac-6\u7fa4\u3067\u306f\u7d05\u6591\u3068\u8131\u5c51\u306e\u6539\u5584\uff08P &lt; 0.05\uff09\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\u306e\u8840\u4e2d\u6fc3\u5ea6\u3068\u81e8\u5e8a\u6539\u5584\u3068\u306e\u9593\u306b\u306f\u4e2d\u7b49\u5ea6\u306e\u9006\u76f8\u95a2\u304c\u3042\u308a\uff08\u76f8\u95a2\u4fc2\u6570 r \u2248 \u22120.35\u3001P &lt; 0.05\uff09\u3001\u5c11\u306a\u304f\u3068\u3082\u4e00\u90e8\u306e\u75c7\u72b6\u306b\u5bfe\u3057\u3066\u306f\u52b9\u679c\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3064\u307e\u308a\u3001\u30aa\u30e1\u30ac\u8102\u80aa\u9178\u306b\u3088\u308b\u52b9\u679c\u306f\u300c\u4e7e\u766c\u3092\u6839\u672c\u7684\u306b\u6cbb\u3059\u300d\u3082\u306e\u3067\u306f\u306a\u3044\u306b\u305b\u3088\u3001\u75c7\u72b6\u3092\u7de9\u548c\u3059\u308b\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u306f\u5341\u5206\u306a\u79d1\u5b66\u7684\u6839\u62e0\u304c\u5b58\u5728\u3059\u308b\u3068\u8a00\u3048\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30d3\u30bf\u30df\u30f3D\uff1a\u6b20\u4e4f\u306f\u76ee\u7acb\u3064\u304c\u3001\u88dc\u5145\u52b9\u679c\u306f\u9650\u5b9a\u7684<\/h3>\n\n\n\n<p>\u6b21\u306b\u3001\u4e7e\u766c\u3068\u95a2\u4fc2\u304c\u6df1\u3044\u3068\u3055\u308c\u308b\u30d3\u30bf\u30df\u30f3\u304c\u3001\u300c\u30d3\u30bf\u30df\u30f3D\uff0825-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\uff09\u300d\u3067\u3059\u3002\u3053\u306e\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u306f\u3001\u514d\u75ab\u7d30\u80de\uff08\u7279\u306bT\u7d30\u80de\uff09\u306e\u8abf\u7bc0\u3001\u76ae\u819a\u306e\u5206\u5316\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u7dad\u6301\u306a\u3069\u306b\u95a2\u4e0e\u3057\u3001\u65e5\u5149\u3092\u6d74\u3073\u308b\u3053\u3068\u3067\u4f53\u5185\u5408\u6210\u3055\u308c\u308b\u70b9\u3067\u3082\u8208\u5473\u6df1\u3044\u5b58\u5728\u3067\u3059\u3002<\/p>\n\n\n\n<p>2\u3064\u306e\u89b3\u5bdf\u7814\u7a76\u3067\u306f\u3001\u4e7e\u766c\u60a3\u8005\u306e\u8840\u4e2d25(OH)D\u6fc3\u5ea6\u306f\u5e73\u574713.3ng\/mL\u3067\u3042\u308a\u3001\u5065\u5e38\u8005\u306e22.4ng\/mL\u3068\u6bd4\u3079\u3066\u6709\u610f\u306b\u4f4e\u3044\u5024\u3092\u793a\u3057\u307e\u3057\u305f\uff08P = 0.004\uff09\u3002\u307e\u305f\u300120ng\/mL\u672a\u6e80\u3092\u300c\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u300d\u3068\u5b9a\u7fa9\u3057\u305f\u5834\u5408\u3001\u305d\u306e\u5272\u5408\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e7e\u766c\u60a3\u8005\uff1a57.8%<br><\/li>\n\n\n\n<li>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u60a3\u8005\uff1a37.5%<br><\/li>\n\n\n\n<li>\u5065\u5eb7\u5bfe\u7167\u7fa4\uff1a29.7%\uff08P &lt; 0.001\uff09<br><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u4e7e\u766c\u60a3\u8005\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306f\u975e\u5e38\u306b\u9ad8\u983b\u5ea6\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u88dc\u5145\u306b\u3088\u308b\u81e8\u5e8a\u7684\u306a\u6539\u5584\u52b9\u679c\u306f\u3001\u4eca\u306e\u3068\u3053\u308d\u4e00\u8cab\u3057\u305f\u6210\u679c\u304c\u5f97\u3089\u308c\u3066\u304a\u3089\u305a\u3001\u300c\u6b20\u4e4f\u306f\u88dc\u3046\u3079\u304d\u3060\u304c\u3001\u6cbb\u7642\u3068\u3057\u3066\u306e\u52b9\u679c\u306f\u9650\u5b9a\u7684\u300d\u3068\u3044\u3046\u898b\u89e3\u304c\u4e3b\u6d41\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8178\u5185\u74b0\u5883\uff1a\u898b\u3048\u3056\u308b\u300c\u8178-\u76ae\u819a\u8ef8\u300d<\/h3>\n\n\n\n<p>\u4e7e\u766c\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001\u8178\u5185\u74b0\u5883\u306e\u5909\u5316\u2015\u2015\u3068\u308a\u308f\u3051\u8178\u5185\u7d30\u83cc\u53e2\u306e\u591a\u69d8\u6027\u4f4e\u4e0b\u3068\u3001\u8178\u7ba1\u30d0\u30ea\u30a2\u306e\u7834\u7dbb\u306b\u3088\u308b\u5185\u56e0\u6027\u6bd2\u7d20\u306e\u6f0f\u51fa\u3067\u3059\u3002\u30ea\u30dd\u591a\u7cd6\uff08LPS\uff09\u3084\u30da\u30d7\u30c1\u30c9\u30b0\u30ea\u30ab\u30f3\u3068\u3044\u3063\u305f\u8178\u5185\u306e\u5fae\u751f\u7269\u7531\u6765\u6210\u5206\u304c\u8840\u4e2d\u306b\u79fb\u884c\u3057\u3001\u305d\u308c\u304c\u5168\u8eab\u6027\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u300c\u8178-\u76ae\u819a\u8ef8\uff08gut-skin axis\uff09\u300d\u3068\u3044\u3046\u6982\u5ff5\u306f\u3001\u4e7e\u766c\u304c\u76ae\u819a\u306e\u307f\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u4ee3\u8b1d\u75be\u60a3\u3084\u6162\u6027\u708e\u75c7\u6027\u75be\u60a3\u3068\u6df1\u304f\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u91cd\u8981\u3067\u3059\u3002\u305d\u3057\u3066\u305d\u306e\u9375\u3092\u63e1\u308b\u306e\u304c\u3001\u65e5\u3005\u306e\u98df\u751f\u6d3b\u3067\u3042\u308b\u3053\u3068\u306f\u3001\u8a00\u3046\u307e\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c\u4e94\u7ae0\uff1a\u76ae\u819a\u306e\u5206\u5b50\u6a5f\u69cb\u3068\u6804\u990a\u306e\u4ea4\u5dee\u70b9<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u2014 \u7d30\u80de\u3068\u6804\u990a\u7d20\u304c\u8a9e\u308b\u300c\u8001\u5316\u300d\u306e\u7269\u8a9e \u2014<\/sup><\/p>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u76ae\u819a\u306f\u3001\u305f\u3060\u306e\u300c\u5916\u5074\u306e\u819c\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u306f\u4f53\u5185\u3067\u6700\u3082\u5e83\u3044\u5668\u5b98\u3067\u3042\u308a\u3001\u6e29\u5ea6\u8abf\u7bc0\u3001\u514d\u75ab\u5fdc\u7b54\u3001\u7d2b\u5916\u7dda\u9632\u5fa1\u3001\u305d\u3057\u3066\u5fc3\u3068\u793e\u4f1a\u3092\u3064\u306a\u3050\u300c\u898b\u3048\u308b\u5065\u5eb7\u300d\u306e\u8c61\u5fb4\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4e00\u679a\u306e\u819c\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u898b\u3066\u3044\u304f\u3068\u3001\u305d\u3053\u306b\u306f\u60f3\u50cf\u3092\u306f\u308b\u304b\u306b\u8d85\u3048\u308b\u7cbe\u5bc6\u306a\u6a5f\u69cb\u3068\u3001\u6804\u990a\u3068\u306e\u5bc6\u63a5\u306a\u5bfe\u8a71\u304c\u5e83\u304c\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30c6\u30ed\u30e1\u30a2\uff1a\u5bff\u547d\u306e\u7802\u6642\u8a08\u3068\u690d\u7269\u6027\u98df\u4e8b<\/h3>\n\n\n\n<p>\u3059\u3079\u3066\u306e\u7d30\u80de\u306e\u4e2d\u306b\u3042\u308b\u67d3\u8272\u4f53\u306e\u672b\u7aef\u306b\u306f\u3001\u300c\u30c6\u30ed\u30e1\u30a2\uff08telomere\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u53cd\u5fa9\u5869\u57fa\u914d\u5217\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u7d30\u80de\u5206\u88c2\u306e\u305f\u3073\u306b\u77ed\u304f\u306a\u308a\u3001\u3084\u304c\u3066\u9650\u754c\u306b\u9054\u3059\u308b\u3068\u3001\u7d30\u80de\u306f\u300c\u8001\u5316\uff08senescence\uff09\u300d\u307e\u305f\u306f\u300c\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u7d30\u80de\u6b7b\uff09\u300d\u306b\u5411\u304b\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u30c6\u30ed\u30e1\u30a2\u306f\u7d30\u80de\u5bff\u547d\u306e\u7802\u6642\u8a08\u306a\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001\u3053\u306e\u7802\u6642\u8a08\u306e\u6e1b\u308a\u65b9\u306f\u3001\u98df\u4e8b\u3068\u751f\u6d3b\u7fd2\u6163\u306b\u3088\u3063\u3066\u5909\u3048\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u81e8\u5e8a\u7814\u7a76\u306e\u7b2c\u4e00\u4eba\u8005\u3067\u3042\u308b\u30c7\u30a3\u30fc\u30f3\u30fb\u30aa\u30fc\u30cb\u30c3\u30b7\u30e5\u535a\u58eb\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u7814\u7a76\u3067\u306f\u3001\u690d\u7269\u6027\u4e2d\u5fc3\u306e\u5168\u98df\u54c1\u98df\uff08Whole-Food Plant-Based Diet, WFPB\uff09\u3001\u30b9\u30c8\u30ec\u30b9\u4f4e\u6e1b\u3001\u9069\u5ea6\u306a\u904b\u52d5\u30925\u5e74\u9593\u7d99\u7d9a\u3057\u305f\u7537\u6027\u7fa4\u306b\u304a\u3044\u3066\u3001\u30c6\u30ed\u30e1\u30a2\u306e\u9577\u3055\u304c\u6709\u610f\u306b\u5ef6\u9577\u3057\u305f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u300c\u8001\u5316\u304c\u9045\u3089\u305b\u3089\u308c\u308b\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u4e00\u90e8\u9006\u8ee2\u3055\u305b\u3089\u308c\u308b\u300d\u53ef\u80fd\u6027\u3092\u3082\u793a\u5506\u3059\u308b\u3001\u6b74\u53f2\u7684\u306a\u767a\u898b\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff1a\u7d30\u80de\u306e\u6575\u3068\u6297\u9178\u5316\u6804\u990a\u7d20\u306e\u76fe<\/h3>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u4f53\u3067\u306f\u65e5\u3005\u3001\u4ee3\u8b1d\u3084\u7d2b\u5916\u7dda\u3001\u6c5a\u67d3\u7269\u8cea\u306b\u3088\u308a\u300c\u6d3b\u6027\u9178\u7d20\u7a2e\uff08Reactive Oxygen Species, ROS\uff09\u300d\u304c\u767a\u751f\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u907a\u4f1d\u5b50\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u8102\u8cea\u306b\u640d\u50b7\u3092\u4e0e\u3048\u308b\u5371\u967a\u306a\u5b58\u5728\u3067\u3042\u308a\u3001\u76ae\u819a\u306b\u304a\u3044\u3066\u306f\u3057\u308f\u3084\u305f\u308b\u307f\u3001\u30b7\u30df\u3001\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u4e3b\u8981\u56e0\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306eROS\u306b\u5bfe\u6297\u3059\u308b\u306e\u304c\u3001\u30d3\u30bf\u30df\u30f3\u3084\u690d\u7269\u7531\u6765\u306e\u6297\u9178\u5316\u7269\u8cea\u3067\u3059\u3002\u4ee5\u4e0b\u306b\u4ee3\u8868\u4f8b\u3092\u7d39\u4ecb\u3057\u307e\u3057\u3087\u3046\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d3\u30bf\u30df\u30f3E\uff08\u03b1-\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\uff1a\u8102\u6eb6\u6027\u3067\u7d30\u80de\u819c\u3092\u4fdd\u8b77\u3002\u76ae\u819a\u7d30\u80de\u306e\u8102\u8cea\u9178\u5316\u3092\u9632\u304e\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u30d3\u30bf\u30df\u30f3C\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\uff1a\u6c34\u6eb6\u6027\u3067\u3001\u9178\u5316\u3057\u305f\u30d3\u30bf\u30df\u30f3E\u3092\u518d\u751f\u3002\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u306b\u3082\u5fc5\u9808\u3002<br><\/li>\n\n\n\n<li>\u30d3\u30bf\u30df\u30f3A\uff08\u30ec\u30c1\u30ce\u30a4\u30c9\uff09\uff1a\u7d30\u80de\u306e\u5897\u6b96\u3068\u5206\u5316\u3092\u5236\u5fa1\u3002MMP\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\uff09\u306e\u6291\u5236\u306b\u3082\u95a2\u4e0e\u3002<br><\/li>\n\n\n\n<li>\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\uff08CoQ10\uff09\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3068\u6297\u9178\u5316\u306b\u95a2\u4e0e\u3002\u7d2b\u5916\u7dda\u306b\u3088\u308b\u3057\u308f\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br><\/li>\n\n\n\n<li>\u30af\u30ed\u30ed\u30d5\u30a3\u30eb\u304a\u3088\u3073\u30af\u30ed\u30ed\u30d5\u30a3\u30ea\u30f3\uff08chlorophyll, chlorophyllin\uff09\uff1a\u767a\u304c\u3093\u7269\u8cea\u3068\u7d50\u5408\u3057\u3001\u305d\u306e\u5438\u53ce\u3092\u963b\u6b62\u3002<br><\/li>\n\n\n\n<li>\u30bc\u30a2\u30ad\u30b5\u30f3\u30c1\u30f3\u3001\u30eb\u30c6\u30a4\u30f3\uff1a\u76ee\u306b\u826f\u3044\u3053\u3068\u3067\u77e5\u3089\u308c\u307e\u3059\u304c\u3001\u76ae\u819a\u306e\u6c34\u5206\u4fdd\u6301\u3084\u5f3e\u529b\u7dad\u6301\u306b\u3082\u95a2\u4e0e\u3002<br><\/li>\n<\/ul>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u690d\u7269\u7531\u6765\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08polyphenols\uff09\u2015\u2015\u4f8b\u3048\u3070\u7dd1\u8336\u3001\u8d64\u30ef\u30a4\u30f3\u3001\u30c0\u30fc\u30af\u30c1\u30e7\u30b3\u30ec\u30fc\u30c8\u3001\u30d9\u30ea\u30fc\u985e\u306b\u8c4a\u5bcc\u306a\u3053\u308c\u3089\u306e\u6210\u5206\u306f\u3001\u6d3b\u6027\u9178\u7d20\u3092\u4e2d\u548c\u3057\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6297\u9178\u5316\u7269\u8cea\u306f\u3001\u5358\u4f53\u3067\u6442\u53d6\u3059\u308b\u3088\u308a\u3082\u3001\u98df\u7269\u3068\u3057\u3066\u81ea\u7136\u306a\u5f62\u3067\u6442\u308b\u3053\u3068\u306b\u3088\u308a\u76f8\u4e57\u7684\u306a\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u3001\u690d\u7269\u6027\u98df\u54c1\u306b\u306f\u52d5\u7269\u6027\u98df\u54c1\u306e64\u500d\u3082\u306e\u6297\u9178\u5316\u529b\u304c\u3042\u308b\u3068\u3044\u3046\u30c7\u30fc\u30bf\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u9ad8\u6e29\u8abf\u7406\u3068AGEs\uff1a\u8001\u5316\u3092\u52a0\u901f\u3055\u305b\u308b\u201c\u898b\u3048\u306a\u3044\u6bd2\u201d<\/h3>\n\n\n\n<p>\u300c\u713c\u304d\u300d\u300c\u63da\u3052\u300d\u300c\u30ed\u30fc\u30b9\u30c8\u300d\u2015\u2015\u9999\u3070\u3057\u3044\u8abf\u7406\u6cd5\u306b\u306f\u3001\u4eba\u3092\u9b45\u4e86\u3059\u308b\u98a8\u5473\u3068\u5171\u306b\u3001\u808c\u306e\u8001\u5316\u3092\u9032\u3081\u308b\u300cAGEs\uff08Advanced Glycation End-products\uff1a\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u300d\u304c\u6f5c\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>AGEs\u3068\u306f\u3001\u7cd6\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u8102\u8cea\u3068\u975e\u9175\u7d20\u7684\u306b\u7d50\u5408\u3057\u3066\u3067\u304d\u308b\u7269\u8cea\u3067\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u3092\u786c\u5316\u30fb\u5909\u6027\u3055\u305b\u308b\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u7d50\u679c\u3001\u76ae\u819a\u306e\u5f3e\u529b\u306f\u5931\u308f\u308c\u3001\u3057\u308f\u3084\u304f\u3059\u307f\u304c\u9855\u8457\u306b\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001AGEs\u306f\u708e\u75c7\u3092\u8a98\u5c0e\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u60aa\u5316\u3055\u305b\u308b\u3053\u3068\u3067\u300c\u8001\u5316\u306e\u52a0\u901f\u88c5\u7f6e\u300d\u3068\u3057\u3066\u3082\u50cd\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8abf\u7406\u6e29\u5ea6\u304c\u9ad8\u3044\u307b\u3069AGEs\u306e\u751f\u6210\u91cf\u306f\u5897\u52a0\u3057\u3001\u7279\u306b\u8089\u3084\u52a0\u5de5\u98df\u54c1\u3001\u7cd6\u8cea\u306e\u591a\u3044\u304a\u83d3\u5b50\u306a\u3069\u304c\u4e3b\u306a\u4f9b\u7d66\u6e90\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001\u91ce\u83dc\u3084\u679c\u7269\u3001\u5168\u7c92\u7a40\u7269\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u4f4e\u6e29\u8abf\u7406\u306e\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u306f\u3001AGEs\u306e\u4f53\u5185\u84c4\u7a4d\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u3092\u64cd\u4f5c\u3059\u308b\uff1amicroRNA\u3068\u8ee2\u5199\u56e0\u5b50<\/h3>\n\n\n\n<p>\u98df\u4e8b\u306f\u3001\u5358\u306b\u300c\u7d30\u80de\u306e\u6750\u6599\u300d\u3092\u4e0e\u3048\u308b\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u6804\u990a\u7d20\u304c\u907a\u4f1d\u5b50\u306e\u50cd\u304d\uff08\u767a\u73fe\uff09\u3092\u76f4\u63a5\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001microRNA\uff08\u30de\u30a4\u30af\u30edRNA\uff09\u3068\u547c\u3070\u308c\u308b\u77ed\u3044RNA\u65ad\u7247\u306f\u3001\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u6301\u3061\u307e\u3059\u3002\u4ee5\u4e0b\u306f\u3001\u76ae\u819a\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3055\u308c\u308bmicroRNA\u306e\u4f8b\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>miR-34\uff1a\u7d30\u80de\u5468\u671f\u505c\u6b62\u3092\u8a98\u5c0e\u3057\u3001\u8001\u5316\u3092\u4fc3\u9032\u3002<br><\/li>\n\n\n\n<li>miR-378b\uff1a\u30b3\u30e9\u30fc\u30b2\u30f3\u751f\u6210\u6291\u5236\u3001\u76ae\u819a\u306e\u5f3e\u529b\u4f4e\u4e0b\u3002<br><\/li>\n\n\n\n<li>miR-217\uff1a\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306e\u5408\u6210\u4f4e\u4e0b\u306b\u95a2\u4e0e\u3002<br><\/li>\n<\/ul>\n\n\n\n<p>\u307e\u305f\u3001\u98df\u4e8b\u306b\u542b\u307e\u308c\u308b\u6210\u5206\u306f\u3001NF-\u03baB\uff08\u6838\u56e0\u5b50\u30ab\u30c3\u30d1B\uff09\u3084AP-1\uff08\u30a2\u30af\u30c6\u30a3\u30d9\u30fc\u30bf\u30fc\u30d7\u30ed\u30c6\u30a4\u30f31\uff09\u3001Nrf2\uff08\u6838\u5185\u56e0\u5b50\u30a8\u30ea\u30b9\u30ed\u30a4\u30c92\u95a2\u9023\u56e0\u5b502\uff09\u3068\u3044\u3063\u305f\u8ee2\u5199\u56e0\u5b50\u306e\u6d3b\u6027\u3092\u8abf\u6574\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u6297\u9178\u5316\u9175\u7d20\u306e\u7523\u751f\u3084MMP\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u9175\u7d20\uff09\u306e\u767a\u73fe\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u3001\u8001\u5316\u306e\u9032\u884c\u306b\u30d6\u30ec\u30fc\u30ad\u3092\u304b\u3051\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u307e\u3067\u898b\u3066\u304d\u305f\u3088\u3046\u306b\u3001\u79c1\u305f\u3061\u304c\u6bce\u65e5\u53e3\u306b\u3059\u308b\u98df\u54c1\u306e\u4e00\u3064\u3072\u3068\u3064\u304c\u3001\u808c\u7d30\u80de\u306e\u5185\u90e8\u3067\u6975\u3081\u3066\u9ad8\u5ea6\u306a\u201c\u5206\u5b50\u5bfe\u8a71\u201d\u3092\u7e70\u308a\u5e83\u3052\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u305d\u306e\u5bfe\u8a71\u304c\u5065\u5168\u3067\u3042\u308c\u3070\u3001\u808c\u306f\u8f1d\u304d\u3001\u56de\u5fa9\u529b\u3092\u4fdd\u3061\u3001\u708e\u75c7\u306b\u5f37\u304f\u306a\u308a\u307e\u3059\u3002\u9006\u306b\u3001\u30d0\u30e9\u30f3\u30b9\u3092\u6b20\u3044\u305f\u98df\u751f\u6d3b\u306f\u3001\u305d\u306e\u5bfe\u8a71\u3092\u6df7\u4e71\u3055\u305b\u3001\u8001\u5316\u3084\u75be\u60a3\u306e\u5f15\u304d\u91d1\u3068\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066\u3053\u306e\u3053\u3068\u306f\u3001\u808c\u306e\u82e5\u3055\u3084\u7f8e\u3057\u3055\u304c\u300c\u5316\u7ca7\u54c1\u300d\u3084\u300c\u533b\u85ac\u54c1\u300d\u3060\u3051\u3067\u4f5c\u3089\u308c\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u6bce\u65e5\u306e\u98df\u5353\u304b\u3089\u59cb\u307e\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u3001\u4f55\u3088\u308a\u3082\u96c4\u5f01\u306b\u7269\u8a9e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7b2c\u516d\u7ae0\uff1a\u98df\u3068\u76ae\u819a\u533b\u7642\u306e\u3053\u308c\u304b\u3089<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u2014 \u4e88\u9632\u304b\u3089\u6cbb\u7642\u3078\u306e\u98df\u5353\u9769\u547d \u2014<\/sup><\/p>\n\n\n\n<p>\u3082\u3057\u3001\u3042\u306a\u305f\u304c\u6bce\u671d\u93e1\u3092\u306e\u305e\u304d\u8fbc\u3080\u3068\u304d\u3001\u808c\u306b\u4f55\u3089\u304b\u306e\u30b5\u30a4\u30f3\u3092\u611f\u3058\u53d6\u3063\u3066\u3044\u308b\u3068\u3059\u308c\u3070\u2015\u2015\u4e7e\u71e5\u3001\u304f\u3059\u307f\u3001\u5439\u304d\u51fa\u7269\u3001\u3042\u308b\u3044\u306f\u5e74\u9f62\u306b\u3088\u308b\u30b7\u30ef\u3084\u305f\u308b\u307f\u3002\u305d\u3046\u3057\u305f\u5909\u5316\u306e\u591a\u304f\u306f\u3001\u5316\u7ca7\u54c1\u3084\u5916\u7528\u85ac\u306e\u529b\u3067\u306f\u5c4a\u304b\u306a\u3044\u201c\u6839\u672c\u7684\u306a\u4f53\u5185\u8981\u56e0\u201d\u306b\u7531\u6765\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u306e\u7ae0\u3067\u898b\u3066\u304d\u305f\u901a\u308a\u3001\u76ae\u819a\u306e\u5065\u5eb7\u72b6\u614b\u306f\u3001\u4ee3\u8b1d\u3001\u514d\u75ab\u3001\u9178\u5316\u3001\u8178\u5185\u74b0\u5883\u3068\u3044\u3063\u305f\u5168\u8eab\u306e\u6a5f\u80fd\u306e\u96c6\u7a4d\u7684\u306a\u7d50\u679c\u3067\u3042\u308a\u3001\u305d\u306e\u4e2d\u5fc3\u306b\u3042\u308b\u306e\u304c\u300c\u98df\u751f\u6d3b\u300d\u3067\u3042\u308b\u3053\u3068\u306f\u3082\u306f\u3084\u7591\u3046\u4f59\u5730\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u3067\u306f\u3001\u6700\u65b0\u306e\u79d1\u5b66\u7684\u77e5\u898b\u306b\u57fa\u3065\u3044\u3066\u3001\u76ae\u819a\u75be\u60a3\u3084\u8001\u5316\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u306b\u6709\u52b9\u3068\u3055\u308c\u308b\u98df\u4e8b\u6226\u7565\u3092\u7dcf\u62ec\u3057\u3001\u81e8\u5e8a\u30fb\u5bb6\u5ead\u306e\u53cc\u65b9\u306b\u304a\u3051\u308b\u5b9f\u8df5\u65b9\u6cd5\u3092\u63d0\u6848\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u79d1\u5b66\u306b\u88cf\u4ed8\u3051\u3089\u308c\u305f\u300c\u76ae\u819a\u306e\u305f\u3081\u306e\u98df\u4e8b\u300d\u306e\u67f1<\/h3>\n\n\n\n<p>\u76ae\u819a\u306e\u5065\u5eb7\u3092\u5b88\u308b\u3046\u3048\u3067\u6700\u3082\u91cd\u8981\u306a\u306e\u306f\u3001\u300c\u7279\u5b9a\u306e\u6804\u990a\u7d20\u3092\u53d6\u308b\u3053\u3068\u300d\u3067\u306f\u306a\u304f\u3001\u300c\u5168\u4f53\u3068\u3057\u3066\u30d0\u30e9\u30f3\u30b9\u306e\u3068\u308c\u305f\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u300d\u3067\u3059\u3002\u3053\u308c\u3092\u88cf\u4ed8\u3051\u308b\u8907\u6570\u306e\u7814\u7a76\u304c\u3001\u8fd1\u5e74\u6b21\u3005\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001\u30aa\u30e9\u30f3\u30c0\u306e\u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u300c\u30ed\u30c3\u30c6\u30eb\u30c0\u30e0\u7814\u7a76\u300d\u3067\u306f\u3001\u5065\u5eb7\u7684\u306a\u98df\u4e8b\u6307\u6a19\uff08Dutch Healthy Diet Index, DHDI\uff09\u306e\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u5973\u6027\u307b\u3069\u3001\u9854\u306e\u30b7\u30ef\u306e\u5272\u5408\u304c\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u5c11\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u7d50\u679c\u304c\u51fa\u307e\u3057\u305f\uff0810\u30dd\u30a4\u30f3\u30c8\u4e0a\u6607\u3054\u3068\u306e\u30b7\u30ef\u9762\u7a4d\u6e1b\u5c11\u7387\uff1a\u22124.48%\u3001P = 0.005\uff09\u3002\u307e\u305f\u3001\u679c\u7269\u4e2d\u5fc3\u306e\u30d1\u30bf\u30fc\u30f3\u306f\u30b7\u30ef\u3092\u6e1b\u3089\u3057\uff08\u22123.20%\u3001P = 0.046\uff09\u3001\u52a0\u5de5\u98df\u54c1\u304c\u591a\u3044\u30d1\u30bf\u30fc\u30f3\u3067\u306f\u9006\u306b\u30b7\u30ef\u304c\u5897\u3048\u308b\u3068\u3044\u3046\u50be\u5411\u3082\u898b\u3089\u308c\u307e\u3057\u305f\uff08+3.32%\u3001P = 0.046\uff09\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001\u7537\u6027\u3067\u306f\u3053\u3046\u3057\u305f\u76f8\u95a2\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u3053\u308c\u306f\u679c\u7269\u6442\u53d6\u91cf\u306e\u5c11\u306a\u3055\u3084\u3001\u76ae\u819a\u69cb\u9020\u306e\u6027\u5dee\u3001\u65e5\u5e38\u7684\u306a\u7d2b\u5916\u7dda\u5bfe\u7b56\u884c\u52d5\u306e\u9055\u3044\u306a\u3069\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5b9f\u8df5\u7684\u306a\u98df\u4e8b\u6226\u7565\uff1a\u660e\u65e5\u304b\u3089\u3067\u304d\u308b\u3053\u3068<\/h3>\n\n\n\n<p>\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u3066\u3001\u808c\u3068\u5065\u5eb7\u306e\u305f\u3081\u306b\u660e\u65e5\u304b\u3089\u53d6\u308a\u5165\u308c\u3089\u308c\u308b\u98df\u7fd2\u6163\u3092\u4ee5\u4e0b\u306b\u7d39\u4ecb\u3057\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3059\u3079\u3066\u306f\u300c\u30d0\u30e9\u30f3\u30b9\u300d\u3068\u300c\u6301\u7d9a\u6027\u300d\u304c\u9375\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u25cf \u4f4eGI\u98df\uff08Low Glycemic Index Diet\uff09\u3092\u57fa\u672c\u306b<\/h4>\n\n\n\n<p>\u8840\u7cd6\u306e\u6025\u4e0a\u6607\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u3084\u76ae\u8102\u5206\u6ccc\u306e\u66b4\u8d70\u3092\u9632\u304e\u307e\u3059\u3002\u767d\u7c73\u3088\u308a\u7384\u7c73\u3001\u767d\u30d1\u30f3\u3088\u308a\u5168\u7c92\u7c89\u30d1\u30f3\u3001\u30b8\u30e5\u30fc\u30b9\u3088\u308a\u679c\u7269\u305d\u306e\u3082\u306e\u3092\u9078\u3076\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u25cf \u690d\u7269\u6027\u98df\u54c1\u4e2d\u5fc3\uff08Whole-Food Plant-Based Diet\uff09<\/h4>\n\n\n\n<p>\u6297\u9178\u5316\u7269\u8cea\u3001\u98df\u7269\u7e4a\u7dad\u3001\u30d5\u30a3\u30c8\u30b1\u30df\u30ab\u30eb\u304c\u8c4a\u5bcc\u306a\u91ce\u83dc\u3001\u679c\u7269\u3001\u8c46\u985e\u3001\u5168\u7c92\u7a40\u7269\u3001\u30ca\u30c3\u30c4\u3092\u4e2d\u5fc3\u306b\u636e\u3048\u305f\u98df\u4e8b\u306f\u3001\u76ae\u819a\u306e\u5f3e\u529b\u7dad\u6301\u3068\u708e\u75c7\u6291\u5236\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u25cf \u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\u306e\u6442\u53d6<\/h4>\n\n\n\n<p>\u9752\u9b5a\u3001\u4e9c\u9ebb\u4ec1\u6cb9\u3001\u30c1\u30a2\u30b7\u30fc\u30c9\u3001\u30af\u30eb\u30df\u3001\u6d77\u85fb\u306a\u3069\u304b\u3089EPA\/DHA\u3084\u03b1-\u30ea\u30ce\u30ec\u30f3\u9178\u3092\u7a4d\u6975\u7684\u306b\u6442\u308a\u307e\u3057\u3087\u3046\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4e7e\u766c\u3084\u30cb\u30ad\u30d3\u306a\u3069\u306e\u708e\u75c7\u6027\u75be\u60a3\u306e\u6539\u5584\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u25cf \u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3092\u4e3b\u8102\u80aa\u6e90\u306b<\/h4>\n\n\n\n<p>\u30d5\u30e9\u30f3\u30b9SU.VI.MAX\u7814\u7a76\u306a\u3069\u304b\u3089\u306f\u3001\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306b\u542b\u307e\u308c\u308b\u30aa\u30ec\u30a4\u30f3\u9178\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30b9\u30af\u30a2\u30ec\u30f3\u306a\u3069\u304c\u5149\u8001\u5316\u304b\u3089\u76ae\u819a\u3092\u5b88\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u25cf \u30d3\u30bf\u30df\u30f3D\u3001E\u3001C\u3001\u4e9c\u925b\u306a\u3069\u306e\u4e0d\u8db3\u306b\u6ce8\u610f<\/h4>\n\n\n\n<p>\u7279\u306b\u4e7e\u766c\u3084\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u6804\u990a\u7d20\u306e\u6b20\u4e4f\u304c\u75be\u60a3\u306e\u91cd\u75c7\u5316\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u8840\u6db2\u691c\u67fb\u3092\u57fa\u306b\u9069\u5207\u306a\u88dc\u5145\u3092\u884c\u3046\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u25cf \u52a0\u5de5\u98df\u54c1\u30fb\u7cd6\u8cea\u30fbAGEs\u306e\u591a\u3044\u98df\u54c1\u3092\u63a7\u3048\u308b<\/h4>\n\n\n\n<p>\u904e\u5270\u306a\u7cd6\u8cea\u3084\u30c8\u30e9\u30f3\u30b9\u8102\u80aa\u9178\u3001\u9ad8\u6e29\u8abf\u7406\u98df\u54c1\uff08\u30d5\u30e9\u30a4\u3001\u713c\u304d\u83d3\u5b50\u3001\u30b0\u30ea\u30eb\u8089\uff09\u306fAGEs\u3092\u5897\u52a0\u3055\u305b\u3001\u808c\u306e\u5f3e\u529b\u3084\u4fee\u5fa9\u6a5f\u80fd\u3092\u640d\u306a\u3046\u6050\u308c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u672a\u6765\u306e\u76ae\u819a\u79d1\u533b\u7642\u306f\u300c\u98df\u4e8b\u3068\u5171\u306b\u3042\u308b\u300d<\/h3>\n\n\n\n<p>\u76ae\u819a\u79d1\u5b66\u304c\u98df\u4e8b\u306b\u6ce8\u76ee\u3057\u59cb\u3081\u305f\u306e\u306f\u3001\u3064\u3044\u6700\u8fd1\u306e\u3053\u3068\u3067\u3059\u3002\u304b\u3064\u3066\u306f\u76ae\u819a\u306e\u75c5\u6c17\u306b\u300c\u98df\u4e8b\u306f\u7121\u95a2\u4fc2\u300d\u3068\u3055\u308c\u3066\u3044\u305f\u6642\u4ee3\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u4eca\u3001\u79c1\u305f\u3061\u306f\u660e\u78ba\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u7d71\u8a08\u3092\u624b\u306b\u3057\u3066\u3001\u300c\u76ae\u819a\u3068\u98df\u306e\u9593\u306b\u306f\u3001\u5207\u3063\u3066\u3082\u5207\u308c\u306a\u3044\u56e0\u679c\u95a2\u4fc2\u304c\u3042\u308b\u300d\u3068\u80f8\u3092\u5f35\u3063\u3066\u8a00\u3048\u308b\u6642\u4ee3\u306b\u751f\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066\u3053\u306e\u767a\u898b\u306f\u3001\u533b\u5e2b\u3060\u3051\u3067\u306a\u304f\u3001\u3059\u3079\u3066\u306e\u4eba\u306b\u3068\u3063\u3066\u306e\u300c\u751f\u6d3b\u306e\u9078\u629e\u80a2\u300d\u3092\u5e83\u3052\u308b\u3082\u306e\u3067\u3059\u3002\u5316\u7ca7\u54c1\u3084\u5916\u7528\u85ac\u3060\u3051\u306b\u983c\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u81ea\u5206\u306e\u624b\u3067\u3001\u30d5\u30a9\u30fc\u30af\u3068\u30b9\u30d7\u30fc\u30f3\u3067\u3001\u808c\u306e\u672a\u6765\u3092\u9078\u3076\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d42\u7ae0\u306b\u5bc4\u305b\u3066\uff1a\u93e1\u306e\u5411\u3053\u3046\u306b\u3042\u308b\u300c\u65e5\u3005\u306e\u9078\u629e\u300d<\/h2>\n\n\n\n<p>\u808c\u306f\u3001\u3042\u306a\u305f\u306e\u4f53\u306e\u4e2d\u3067\u6700\u3082\u5916\u306b\u3042\u308b\u5185\u81d3\u3067\u3059\u3002\u305d\u306e\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u306f\u3001\u6628\u65e5\u306e\u98df\u4e8b\u3001\u4eca\u65e5\u306e\u30b9\u30c8\u30ec\u30b9\u3001\u660e\u65e5\u306e\u5e0c\u671b\u306b\u307e\u3067\u5f71\u97ff\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u66f8\u3092\u901a\u3058\u3066\u3001\u76ae\u819a\u8001\u5316\u3068\u75be\u60a3\u306b\u304a\u3051\u308b\u6804\u990a\u306e\u5f79\u5272\u3092\u77e5\u3063\u305f\u3042\u306a\u305f\u304c\u3001\u6bce\u65e5\u306e\u98df\u5353\u3092\u307b\u3093\u306e\u5c11\u3057\u3060\u3051\u898b\u76f4\u3059\u3053\u3068\u3067\u3001\u6570\u5e74\u5f8c\u306e\u808c\u306b\u512a\u3057\u3044\u5149\u304c\u5dee\u3057\u8fbc\u3080\u3053\u3068\u3092\u9858\u3063\u3066\u3084\u307f\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066\u79c1\u305f\u3061\u533b\u7642\u8005\u3082\u307e\u305f\u3001\u300c\u98df\u306e\u529b\u300d\u3092\u78ba\u304b\u306a\u77e5\u8b58\u3068\u5171\u306b\u8a9e\u308c\u308b\u5b58\u5728\u3067\u3042\u308b\u3079\u304d\u3067\u3059\u3002\u76ae\u819a\u79d1\u5b66\u3068\u6804\u990a\u5b66\u306e\u3042\u3044\u3060\u306b\u3001\u3053\u308c\u304b\u3089\u3082\u7f8e\u3057\u3044\u5bfe\u8a71\u304c\u7d9a\u3044\u3066\u3044\u304f\u3053\u3068\u3092\u4fe1\u3058\u3066\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u306f\uff1f<\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\uff08\u4e00\u822c\u540d\uff1a\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff09\u306f\u3001\u90311\u56de\u306e\u6ce8\u5c04\u3067\u4f7f\u7528\u3059\u308b\u7cd6\u5c3f\u75c5\u30fb\u80a5\u6e80\u75c7\u6cbb\u7642\u85ac\u3067\u3001GLP-1\u53d7\u5bb9\u4f53\u3068GIP\u53d7\u5bb9\u4f53\u306e\u4e21\u65b9\u306b\u4f5c\u7528\u3059\u308b\u4e16\u754c\u521d\u306e\u300c\u30c7\u30e5\u30a2\u30eb\u30a2\u30b4\u30cb\u30b9\u30c8\u300d\u3067\u3059\u3002GLP-1\u306f\u98df\u6b32\u6291\u5236\u3084\u80c3\u6392\u51fa\u306e\u9045\u5ef6\u3001\u8840\u7cd6\u4e0a\u6607\u306e\u6291\u5236\u306b\u50cd\u304d\u3001GIP\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u3057\u7cd6\u30fb\u8102\u8cea\u4ee3\u8b1d\u3092\u6539\u5584\u3057\u307e\u3059\u3002<br>\u80a5\u6e80\u3084\u7cd6\u4ee3\u8b1d\u7570\u5e38\u306f\u3001\u808c\u8001\u5316\u3084\u708e\u75c7\u6027\u76ae\u819a\u75be\u60a3\uff08\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3001\u4e7e\u766c\u3001\u30cb\u30ad\u30d3\u306a\u3069\uff09\u306e\u60aa\u5316\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u9ad8\u8840\u7cd6\u3084\u904e\u5270\u306a\u8102\u80aa\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u6162\u6027\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u3084\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u62db\u304d\u307e\u3059\u3002\u30de\u30f3\u30b8\u30e3\u30ed\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001\u8840\u7cd6\u5024\u3084\u5185\u81d3\u8102\u80aa\u3092\u6e1b\u3089\u3059\u3053\u3068\u3067\u3001\u9178\u5316\u3084\u708e\u75c7\u306e\u8ca0\u62c5\u3092\u8efd\u6e1b\u3057\u3001\u808c\u74b0\u5883\u3092\u6574\u3048\u308b\u30b5\u30dd\u30fc\u30c8\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<br>\u305f\u3060\u3057\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u6804\u990a\u7d20\u305d\u306e\u3082\u306e\u3092\u88dc\u3046\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30d3\u30bf\u30df\u30f3C\u3084\u03b2-\u30ab\u30ed\u30c6\u30f3\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306a\u3069\u808c\u306e\u6297\u9178\u5316\u529b\u3092\u9ad8\u3081\u308b\u6804\u990a\u7d20\u3092\u3001\u91ce\u83dc\u30fb\u679c\u7269\u30fb\u826f\u8cea\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u3057\u3063\u304b\u308a\u6442\u53d6\u3057\u3001\u85ac\u3068\u98df\u4e8b\u306e\u4e21\u8f2a\u3067\u5185\u5074\u304b\u3089\u808c\u3092\u5b88\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 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class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31039233\/\">Soliman YS, Hashim PW, Farberg AS, Goldenberg G. The role of diet in preventing photoaging and treating common skin conditions. Cutis. 2019 Mar;103(3):153-156. PMID: 31039233.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0044490\">Latreille, Julie, et al. \u2018Dietary Monounsaturated Fatty Acids Intake and Risk of Skin Photoaging\u2019. <em>PLoS ONE<\/em>, edited by H. Peter Soyer, vol. 7, no. 9, Sept. 2012, p. e44490. <em>DOI.org (Crossref)<\/em>, https:\/\/doi.org\/10.1371\/journal.pone.0044490.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7380694\/\">Solway J, McBride M, Haq F, Abdul W, Miller R. Diet and Dermatology: The Role of a Whole-food, Plant-based Diet in Preventing and Reversing Skin Aging-A Review. J Clin Aesthet Dermatol. 2020 May;13(5):38-43. Epub 2020 May 1. PMID: 32802255; PMCID: PMC7380694.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu12030870\">Cao, Changwei, et al. \u2018Diet and Skin Aging\u2014From the Perspective of Food Nutrition\u2019. <em>Nutrients<\/em>, vol. 12, no. 3, Mar. 2020, p. 870. <em>DOI.org (Crossref)<\/em>, https:\/\/doi.org\/10.3390\/nu12030870.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.jid.2020.06.026\">Hughes, Maria Celia B., et al. \u2018Dietary Antioxidant Capacity and Skin Photoaging: A 15-Year Longitudinal Study\u2019. <em>Journal of Investigative Dermatology<\/em>, vol. 141, no. 4, Apr. 2021, pp. 1111-1118.e2. <em>DOI.org (Crossref)<\/em>, https:\/\/doi.org\/10.1016\/j.jid.2020.06.026.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.jaad.2018.03.033\">Meki\u0107, Selma, et al. \u2018A Healthy Diet in Women Is Associated with Less Facial Wrinkles in a Large Dutch Population-Based Cohort\u2019. <em>Journal of the American Academy of Dermatology<\/em>, vol. 80, 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