{"id":43,"date":"2025-06-06T03:17:26","date_gmt":"2025-06-06T03:17:26","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/diet\/?p=43"},"modified":"2025-08-12T08:37:33","modified_gmt":"2025-08-12T08:37:33","slug":"rosehip-health-benefits-nutrition-research","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/diet\/rosehip-health-benefits-nutrition-research\/","title":{"rendered":"\u8d64\u3044\u5b9d\u77f3\u30fb\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306e\u771f\u4fa1\uff1a\u4f1d\u627f\u3068\u79d1\u5b66\u304c\u7d21\u3050\u672a\u6765\u306e\u5065\u5eb7\u7269\u8a9e"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u7b2c\u4e00\u7ae0\uff1a\u91ce\u306b\u5b9f\u308b\u771f\u7d05\u306e\u5b9d\u77f3\u3001\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u3068\u306e\u51fa\u4f1a\u3044<\/strong><\/h2>\n\n\n\n<p>\u4eba\u306e\u66ae\u3089\u3057\u3068\u690d\u7269\u306e\u95a2\u4fc2\u306f\u3001\u3044\u3064\u306e\u6642\u4ee3\u3082\u6df1\u304f\u3001\u5bc6\u3084\u304b\u306a\u3082\u306e\u3067\u3057\u305f\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001\u3072\u3068\u304d\u308f\u9bae\u3084\u304b\u306b\u3001\u305d\u3057\u3066\u9577\u304f\u611b\u3055\u308c\u3066\u304d\u305f\u679c\u5b9f\u304c\u3042\u308a\u307e\u3059\u3002\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u91ce\u306b\u3001\u3042\u308b\u3044\u306f\u30a2\u30b8\u30a2\u306e\u5c71\u9e93\u306b\u8d64\u304f\u8272\u3065\u304f\u5c0f\u3055\u306a\u679c\u5b9f\u2015\u2015\u305d\u308c\u304c\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\uff08\u82f1\uff1aRose Hip\u3001\u548c\u540d\uff1a\u30ce\u30d0\u30e9\u306e\u5b9f\uff09\u3067\u3059\u3002\u65e5\u672c\u8a9e\u3067\u306f\u300c\u30d0\u30e9\u306e\u5b9f\u300d\u3068\u8a33\u3055\u308c\u308b\u3053\u306e\u679c\u5b9f\u306f\u3001\u5b9f\u306f\u300c\u679c\u5b9f\uff08\u30d5\u30eb\u30fc\u30c4\uff09\u300d\u3068\u3044\u3046\u3088\u308a\u3001\u300c\u507d\u679c\uff08\u304e\u304b\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u3001\u82b1\u306e\u57fa\u90e8\u304c\u81a8\u3089\u3093\u3067\u3067\u304d\u305f\u7279\u5225\u306a\u69cb\u9020\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306f\u3001\u53e4\u304f\u306f\u30ae\u30ea\u30b7\u30e3\u3084\u30ed\u30fc\u30de\u306e\u6642\u4ee3\u304b\u3089\u3001\u6c11\u9593\u85ac\u3084\u6804\u990a\u6e90\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3\u306e\u5b9d\u5eab\u3068\u547c\u3070\u308c\u3001\u7279\u306b\u7b2c\u4e8c\u6b21\u4e16\u754c\u5927\u6226\u4e2d\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3C\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\u306e\u4ee3\u66ff\u6e90\u3068\u3057\u3066\u82f1\u56fd\u3067\u53ce\u7a6b\u30ad\u30e3\u30f3\u30da\u30fc\u30f3\u304c\u884c\u308f\u308c\u305f\u307b\u3069\u3067\u3059\u3002\u73fe\u4ee3\u306b\u5165\u308a\u3001\u79d1\u5b66\u306e\u529b\u3067\u3053\u306e\u8d64\u3044\u5b9f\u306e\u52b9\u80fd\u304c\u6b21\u3005\u306b\u660e\u3089\u304b\u306b\u306a\u308b\u306b\u3064\u308c\u3001\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306f\u300c\u30b9\u30fc\u30d1\u30fc\u30d5\u30fc\u30c9\uff08superfood\uff09\u300d\u3068\u3057\u3066\u518d\u3073\u811a\u5149\u3092\u6d74\u3073\u308b\u3053\u3068\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7b2c\u4e8c\u7ae0\uff1a\u6804\u990a\u306e\u8ff7\u5bae \u2015 \u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306b\u79d8\u3081\u3089\u308c\u305f\u751f\u5316\u5b66\u7684\u69cb\u6210<\/strong><\/h2>\n\n\n\n<p>\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306e\u6804\u990a\u7684\u4fa1\u5024\u306f\u3001\u5358\u306b\u30d3\u30bf\u30df\u30f3C\u304c\u8c4a\u5bcc\u3067\u3042\u308b\u3068\u3044\u3046\u3060\u3051\u306b\u7559\u307e\u308a\u307e\u305b\u3093\u3002\u5b9f\u969b\u306b\u306f\u3001\u6975\u3081\u3066\u591a\u69d8\u306a\u6804\u990a\u7d20\u3068\u751f\u7406\u6d3b\u6027\u6210\u5206\u304c\u7d61\u307f\u5408\u3044\u3001\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u305d\u306e\u6a5f\u80fd\u6027\u304c\u767a\u63ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u7b46\u3059\u3079\u304d\u306f\u3001100g\u3042\u305f\u308a\u6700\u5927426mg\u306e\u30d3\u30bf\u30df\u30f3C\u3092\u542b\u6709\u3057\u3066\u3044\u308b\u70b9\u3067\u3059\u3002\u3053\u308c\u306f\u30ec\u30e2\u30f3\u306e\u304a\u3088\u305d60\u500d\u3068\u3044\u3046\u9a5a\u7570\u7684\u306a\u91cf\u3067\u3042\u308a\u3001\u6297\u9178\u5316\uff08\u3053\u3046\u3055\u3093\u304b\uff09\u4f5c\u7528\u2015\u2015\u3059\u306a\u308f\u3061\u6d3b\u6027\u9178\u7d20\uff08Reactive Oxygen Species, ROS\uff09\u304b\u3089\u7d30\u80de\u3092\u5b88\u308b\u4f5c\u7528\u2015\u2015\u306e\u4e2d\u6838\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3A\uff08\u03b2\u30ab\u30ed\u30c6\u30f3\uff09\u3001E\uff08\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u3001K1\uff08\u30d5\u30a3\u30ed\u30ad\u30ce\u30f3\uff09\u3084\u3001B\u7fa4\u30d3\u30bf\u30df\u30f3\u3082\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u8840\u6db2\u51dd\u56fa\u3001\u795e\u7d4c\u4f1d\u9054\u3001\u9aa8\u306e\u5065\u5eb7\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306b\u306f\u591a\u69d8\u306a\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08Polyphenol\uff09\u3084\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\uff08Flavonoid\uff09\u3082\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u690d\u7269\u7531\u6765\u306e\u6297\u9178\u5316\u7269\u8cea\u3067\u3042\u308a\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u4e88\u9632\u3084\u8001\u5316\u6291\u5236\u306b\u95a2\u4fc2\u3059\u308b\u6210\u5206\u3068\u3057\u3066\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u300c\u30c1\u30ea\u30ed\u30b7\u30c9\uff08Tiliroside\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u4e00\u7a2e\u306f\u3001\u8102\u8cea\u4ee3\u8b1d\u3084\u7cd6\u4ee3\u8b1d\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3001\u6297\u80a5\u6e80\uff08anti-obesity\uff09\u4f5c\u7528\u306e\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30b4\u30dd\uff08GOPO\uff1aGalactolipid of Rosa Canina\uff09\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u306b\u7279\u5316\u3057\u305f\u7279\u7570\u306a\u30ac\u30e9\u30af\u30c8\u8102\u8cea\u3067\u3042\u308a\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3084\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u306e\u7de9\u548c\u306b\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7b2c\u4e09\u7ae0\uff1a\u6d3b\u6027\u9178\u7d20\u306b\u6297\u3046\u529b \u2015 \u6297\u9178\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u771f\u5b9f<\/strong><\/h2>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u4f53\u306f\u3001\u65e5\u3005\u547c\u5438\u3092\u3057\u3001\u98df\u7269\u3092\u71c3\u3084\u3057\u306a\u304c\u3089\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u751f\u307f\u51fa\u3059\u4e00\u65b9\u3067\u3001\u300c\u6d3b\u6027\u9178\u7d20\u300d\u3068\u547c\u3070\u308c\u308b\u6709\u5bb3\u306a\u526f\u7523\u7269\u3082\u751f\u307f\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u7d30\u80de\u819c\u3084DNA\u3092\u50b7\u3064\u3051\u3001\u8001\u5316\u3084\u304c\u3093\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u7cd6\u5c3f\u75c5\u306a\u3069\u306e\u539f\u56e0\u306b\u306a\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u62bd\u51fa\u7269\u306f\u3001DPPH\u3001ABTS\u3001ORAC\u3001FRAP\u3068\u3044\u3063\u305f\u5404\u7a2e\u8a66\u9a13\u3067\u6975\u3081\u3066\u9ad8\u3044\u6297\u9178\u5316\u80fd\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001\u3042\u308b\u7814\u7a76\u3067\u306f\u300187%\u4ee5\u4e0a\u306e\u904e\u9178\u5316\u6c34\u7d20\uff08H\u2082O\u2082\uff09\u3092\u9664\u53bb\u3059\u308b\u80fd\u529b\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\uff08Egea et al., 2010\uff09\u3002\u3055\u3089\u306b\u3001\u7d30\u80de\u5185\u306e\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\uff08\u6297\u9178\u5316\u9175\u7d20\uff09\u306e\u91cf\u3092\u5897\u3084\u3057\u3001\u5185\u76ae\u7d30\u80deDNA\u3078\u306e\u9178\u5316\u7684\u640d\u50b7\u3092\u8efd\u6e1b\u3055\u305b\u305f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\uff08Kerasioti et al., 2019\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u4f5c\u7528\u306f\u3001\u5fc3\u81d3\u75c5\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3001\u708e\u75c7\u6027\u75be\u60a3\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u300c\u9632\u58c1\u300d\u3068\u3057\u3066\u50cd\u304f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7b2c\u56db\u7ae0\uff1a\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3068\u708e\u75c7\u306b\u6311\u3080 \u2015 \u30b4\u30dd\u306e\u529b<\/strong><\/h2>\n\n\n\n<p>\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\uff08Osteoarthritis\uff09\u306f\u3001\u4e2d\u9ad8\u5e74\u306e\u591a\u304f\u304c\u62b1\u3048\u308b\u95a2\u7bc0\u306e\u75db\u307f\u3084\u53ef\u52d5\u57df\u306e\u5236\u9650\u3092\u4f34\u3046\u6162\u6027\u75be\u60a3\u3067\u3059\u3002\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306f\u3001\u3053\u306e\u75c5\u614b\u306b\u5bfe\u3057\u3066\u3082\u660e\u78ba\u306a\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\uff08Winther et al., 2005\uff09\u3067\u306f\u30015g\/\u65e5\u3068\u3044\u3046\u6bd4\u8f03\u7684\u5c11\u91cf\u306e\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u30d1\u30a6\u30c0\u30fc\u6442\u53d6\u306b\u3088\u308a\u300112\u9031\u9593\u3067\u95a2\u7bc0\u306e\u75db\u307f\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u52b9\u679c\u306e\u80cc\u5f8c\u306b\u306f\u3001\u30b4\u30dd\u3068\u3044\u3046\u7279\u7570\u306a\u8102\u8cea\u5206\u5b50\u304c\u5b58\u5728\u3057\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08TNF-\u03b1\u3001IL-1\u03b2\u3001IL-6\uff09\u306e\u5206\u6ccc\u6291\u5236\u3084\u3001\u8edf\u9aa8\u5206\u89e3\u9175\u7d20\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\u3001MMP\uff09\u306e\u963b\u5bb3\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001I\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a2\u30b0\u30ea\u30ab\u30f3\u3068\u3044\u3063\u305f\u8edf\u9aa8\u69cb\u6210\u6210\u5206\u306e\u5408\u6210\u4fc3\u9032\u3082\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u5358\u306a\u308b\u75db\u307f\u306e\u7de9\u548c\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u69cb\u9020\u7684\u306a\u4fee\u5fa9\u52b9\u679c\u3082\u671f\u5f85\u3055\u308c\u308b\u70b9\u3067\u7279\u7b46\u306b\u5024\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7b2c\u4e94\u7ae0\uff1a\u80a5\u6e80\u3068\u7cd6\u4ee3\u8b1d\u3078\u306e\u6311\u6226 \u2015 \u30c1\u30ea\u30ed\u30b7\u30c9\u306e\u9769\u547d<\/strong><\/h2>\n\n\n\n<p>\u73fe\u4ee3\u75c5\u306e\u8c61\u5fb4\u3068\u3082\u3044\u3048\u308b\u80a5\u6e80\u30682\u578b\u7cd6\u5c3f\u75c5\u3002\u305d\u306e\u80cc\u666f\u306b\u306f\u904e\u5270\u306a\u8102\u80aa\u84c4\u7a4d\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u9032\u884c\u304c\u3042\u308a\u307e\u3059\u3002\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306e\u7a2e\u306b\u542b\u307e\u308c\u308b\u30c1\u30ea\u30ed\u30b7\u30c9\u306f\u3001\u307e\u3055\u306b\u3053\u306e\u4ee3\u8b1d\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u5e0c\u671b\u306e\u661f\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>2015\u5e74\u306e\u30d2\u30c8\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08Nagatomo et 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class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.9721\/KJFST.2022.54.4.369\">Jung, T.-H., Hwang, H.-J., &amp; Shin, K.-O. (2022). The nutritional functions and physiological activities of rose hip (<em>Rosa canina<\/em> fruits): A systematic review [\ub85c\uc988\ud799\uc758 \uc601\uc591\ud559\uc801 \uae30\ub2a5 \ubc0f \uc0dd\ub9ac\ud65c\uc131\uc5d0 \ub300\ud55c \ubb38\ud5cc\uc801 \uace0\ucc30]. <em>Korean Journal of Food Science and Technology, 54<\/em>(4), 369\u2013380. https:\/\/doi.org\/10.9721\/KJFST.2022.54.4.369<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.14218\/FIM.2024.00006\">Petersen, Ida Sofie Bjerreg\u00e5rd, and Kaj Winther. \u2018Rose Hip as a Possible Herbal Remedy for Weight Loss: A Systematic Review\u2019. Future Integrative Medicine, vol. 3, no. 2, June 2024, pp. 142\u201352. www.xiahepublishing.com, https:\/\/doi.org\/10.14218\/FIM.2024.00006.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.jnutbio.2011.04.001\">Goto, Tsuyoshi, et al. \u2018Tiliroside, a Glycosidic Flavonoid, Ameliorates Obesity-Induced Metabolic Disorders via Activation of Adiponectin Signaling Followed by Enhancement of Fatty Acid Oxidation in Liver and Skeletal Muscle in Obese\u2013Diabetic Mice\u2019. The Journal of Nutritional Biochemistry, vol. 23, no. 7, July 2012, pp. 768\u201376. DOI.org (Crossref), https:\/\/doi.org\/10.1016\/j.jnutbio.2011.04.001.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1111\/1541-4337.12389\">Grochowski, Daniel M., et al. \u2018A Review on the Dietary Flavonoid Tiliroside\u2019. Comprehensive Reviews in Food Science and Food Safety, vol. 17, no. 5, Sept. 2018, pp. 1395\u2013421. DOI.org (Crossref), https:\/\/doi.org\/10.1111\/1541-4337.12389.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.22271\/tpi.2023.v12.i6a.20743\">Rk, Anushree, and Veena Uk. \u2018An Overview of Functional Potential of Rose Hips\u2019. The Pharma Innovation, vol. 12, no. 6, Jan. 2023, pp. 38\u201343. DOI.org (Crossref), https:\/\/doi.org\/10.22271\/tpi.2023.v12.i6a.20743.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.2174\/1381612824666181010151849\">Ayati, Zahra, et al. \u2018Phytochemistry, Traditional Uses and Pharmacological Profile of Rose Hip: A Review\u2019. Current Pharmaceutical Design, vol. 24, no. 35, Jan. 2019, pp. 4101\u201324. DOI.org (Crossref), https:\/\/doi.org\/10.2174\/1381612824666181010151849.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.7759\/cureus.51225\">Belkhelladi, Malachy. \u2018Effects of Daily Intake of Rosehip Extract on Low-Density Lipoprotein Cholesterol and Blood Glucose Levels: A Systematic Review\u2019. Cureus, Dec. 2023. 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Hip\u3001\u548c\u540d\uff1a\u30ce\u30d0\u30e9\u306e\u5b9f\uff09\u3067\u3059\u3002\u65e5\u672c\u8a9e\u3067\u306f\u300c\u30d0\u30e9\u306e\u5b9f\u300d\u3068\u8a33\u3055\u308c\u308b\u3053\u306e\u679c\u5b9f\u306f\u3001\u5b9f\u306f\u300c\u679c\u5b9f\uff08\u30d5\u30eb\u30fc\u30c4\uff09\u300d\u3068\u3044\u3046\u3088\u308a\u3001\u300c\u507d\u679c\uff08\u304e\u304b\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u3001\u82b1\u306e\u57fa\u90e8\u304c\u81a8\u3089\u3093\u3067\u3067\u304d\u305f\u7279\u5225\u306a\u69cb\u9020\u3092\u3057\u3066\u3044\u307e\u3059\u3002 \u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306f\u3001\u53e4\u304f\u306f\u30ae\u30ea\u30b7\u30e3\u3084\u30ed\u30fc\u30de\u306e\u6642\u4ee3\u304b\u3089\u3001\u6c11\u9593\u85ac\u3084\u6804\u990a\u6e90\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u30d3\u30bf\u30df\u30f3\u306e\u5b9d\u5eab\u3068\u547c\u3070\u308c\u3001\u7279\u306b\u7b2c\u4e8c\u6b21\u4e16\u754c\u5927\u6226\u4e2d\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3C\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\u306e\u4ee3\u66ff\u6e90\u3068\u3057\u3066\u82f1\u56fd\u3067\u53ce\u7a6b\u30ad\u30e3\u30f3\u30da\u30fc\u30f3\u304c\u884c\u308f\u308c\u305f\u307b\u3069\u3067\u3059\u3002\u73fe\u4ee3\u306b\u5165\u308a\u3001\u79d1\u5b66\u306e\u529b\u3067\u3053\u306e\u8d64\u3044\u5b9f\u306e\u52b9\u80fd\u304c\u6b21\u3005\u306b\u660e\u3089\u304b\u306b\u306a\u308b\u306b\u3064\u308c\u3001\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306f\u300c\u30b9\u30fc\u30d1\u30fc\u30d5\u30fc\u30c9\uff08superfood\uff09\u300d\u3068\u3057\u3066\u518d\u3073\u811a\u5149\u3092\u6d74\u3073\u308b\u3053\u3068\u3068\u306a\u308a\u307e\u3057\u305f\u3002 \u7b2c\u4e8c\u7ae0\uff1a\u6804\u990a\u306e\u8ff7\u5bae \u2015 \u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306b\u79d8\u3081\u3089\u308c\u305f\u751f\u5316\u5b66\u7684\u69cb\u6210 \u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306e\u6804\u990a\u7684\u4fa1\u5024\u306f\u3001\u5358\u306b\u30d3\u30bf\u30df\u30f3C\u304c\u8c4a\u5bcc\u3067\u3042\u308b\u3068\u3044\u3046\u3060\u3051\u306b\u7559\u307e\u308a\u307e\u305b\u3093\u3002\u5b9f\u969b\u306b\u306f\u3001\u6975\u3081\u3066\u591a\u69d8\u306a\u6804\u990a\u7d20\u3068\u751f\u7406\u6d3b\u6027\u6210\u5206\u304c\u7d61\u307f\u5408\u3044\u3001\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u305d\u306e\u6a5f\u80fd\u6027\u304c\u767a\u63ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u7279\u7b46\u3059\u3079\u304d\u306f\u3001100g\u3042\u305f\u308a\u6700\u5927426mg\u306e\u30d3\u30bf\u30df\u30f3C\u3092\u542b\u6709\u3057\u3066\u3044\u308b\u70b9\u3067\u3059\u3002\u3053\u308c\u306f\u30ec\u30e2\u30f3\u306e\u304a\u3088\u305d60\u500d\u3068\u3044\u3046\u9a5a\u7570\u7684\u306a\u91cf\u3067\u3042\u308a\u3001\u6297\u9178\u5316\uff08\u3053\u3046\u3055\u3093\u304b\uff09\u4f5c\u7528\u2015\u2015\u3059\u306a\u308f\u3061\u6d3b\u6027\u9178\u7d20\uff08Reactive Oxygen Species, ROS\uff09\u304b\u3089\u7d30\u80de\u3092\u5b88\u308b\u4f5c\u7528\u2015\u2015\u306e\u4e2d\u6838\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3A\uff08\u03b2\u30ab\u30ed\u30c6\u30f3\uff09\u3001E\uff08\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u3001K1\uff08\u30d5\u30a3\u30ed\u30ad\u30ce\u30f3\uff09\u3084\u3001B\u7fa4\u30d3\u30bf\u30df\u30f3\u3082\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u8840\u6db2\u51dd\u56fa\u3001\u795e\u7d4c\u4f1d\u9054\u3001\u9aa8\u306e\u5065\u5eb7\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002 \u3055\u3089\u306b\u3001\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306b\u306f\u591a\u69d8\u306a\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08Polyphenol\uff09\u3084\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\uff08Flavonoid\uff09\u3082\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u690d\u7269\u7531\u6765\u306e\u6297\u9178\u5316\u7269\u8cea\u3067\u3042\u308a\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u4e88\u9632\u3084\u8001\u5316\u6291\u5236\u306b\u95a2\u4fc2\u3059\u308b\u6210\u5206\u3068\u3057\u3066\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u300c\u30c1\u30ea\u30ed\u30b7\u30c9\uff08Tiliroside\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u4e00\u7a2e\u306f\u3001\u8102\u8cea\u4ee3\u8b1d\u3084\u7cd6\u4ee3\u8b1d\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3001\u6297\u80a5\u6e80\uff08anti-obesity\uff09\u4f5c\u7528\u306e\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002 \u307e\u305f\u3001\u30b4\u30dd\uff08GOPO\uff1aGalactolipid of Rosa Canina\uff09\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u306b\u7279\u5316\u3057\u305f\u7279\u7570\u306a\u30ac\u30e9\u30af\u30c8\u8102\u8cea\u3067\u3042\u308a\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u3084\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u306e\u7de9\u548c\u306b\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u7b2c\u4e09\u7ae0\uff1a\u6d3b\u6027\u9178\u7d20\u306b\u6297\u3046\u529b \u2015 \u6297\u9178\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u771f\u5b9f \u79c1\u305f\u3061\u306e\u4f53\u306f\u3001\u65e5\u3005\u547c\u5438\u3092\u3057\u3001\u98df\u7269\u3092\u71c3\u3084\u3057\u306a\u304c\u3089\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u751f\u307f\u51fa\u3059\u4e00\u65b9\u3067\u3001\u300c\u6d3b\u6027\u9178\u7d20\u300d\u3068\u547c\u3070\u308c\u308b\u6709\u5bb3\u306a\u526f\u7523\u7269\u3082\u751f\u307f\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u7d30\u80de\u819c\u3084DNA\u3092\u50b7\u3064\u3051\u3001\u8001\u5316\u3084\u304c\u3093\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u7cd6\u5c3f\u75c5\u306a\u3069\u306e\u539f\u56e0\u306b\u306a\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u62bd\u51fa\u7269\u306f\u3001DPPH\u3001ABTS\u3001ORAC\u3001FRAP\u3068\u3044\u3063\u305f\u5404\u7a2e\u8a66\u9a13\u3067\u6975\u3081\u3066\u9ad8\u3044\u6297\u9178\u5316\u80fd\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001\u3042\u308b\u7814\u7a76\u3067\u306f\u300187%\u4ee5\u4e0a\u306e\u904e\u9178\u5316\u6c34\u7d20\uff08H\u2082O\u2082\uff09\u3092\u9664\u53bb\u3059\u308b\u80fd\u529b\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\uff08Egea et al., 2010\uff09\u3002\u3055\u3089\u306b\u3001\u7d30\u80de\u5185\u306e\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\uff08\u6297\u9178\u5316\u9175\u7d20\uff09\u306e\u91cf\u3092\u5897\u3084\u3057\u3001\u5185\u76ae\u7d30\u80deDNA\u3078\u306e\u9178\u5316\u7684\u640d\u50b7\u3092\u8efd\u6e1b\u3055\u305b\u305f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\uff08Kerasioti et al., 2019\uff09\u3002 \u3053\u306e\u3088\u3046\u306a\u4f5c\u7528\u306f\u3001\u5fc3\u81d3\u75c5\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3001\u708e\u75c7\u6027\u75be\u60a3\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u300c\u9632\u58c1\u300d\u3068\u3057\u3066\u50cd\u304f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002 \u7b2c\u56db\u7ae0\uff1a\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3068\u708e\u75c7\u306b\u6311\u3080 \u2015 \u30b4\u30dd\u306e\u529b \u5909\u5f62\u6027\u95a2\u7bc0\u75c7\uff08Osteoarthritis\uff09\u306f\u3001\u4e2d\u9ad8\u5e74\u306e\u591a\u304f\u304c\u62b1\u3048\u308b\u95a2\u7bc0\u306e\u75db\u307f\u3084\u53ef\u52d5\u57df\u306e\u5236\u9650\u3092\u4f34\u3046\u6162\u6027\u75be\u60a3\u3067\u3059\u3002\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306f\u3001\u3053\u306e\u75c5\u614b\u306b\u5bfe\u3057\u3066\u3082\u660e\u78ba\u306a\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 \u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\uff08Winther et al., 2005\uff09\u3067\u306f\u30015g\/\u65e5\u3068\u3044\u3046\u6bd4\u8f03\u7684\u5c11\u91cf\u306e\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u30d1\u30a6\u30c0\u30fc\u6442\u53d6\u306b\u3088\u308a\u300112\u9031\u9593\u3067\u95a2\u7bc0\u306e\u75db\u307f\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u52b9\u679c\u306e\u80cc\u5f8c\u306b\u306f\u3001\u30b4\u30dd\u3068\u3044\u3046\u7279\u7570\u306a\u8102\u8cea\u5206\u5b50\u304c\u5b58\u5728\u3057\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08TNF-\u03b1\u3001IL-1\u03b2\u3001IL-6\uff09\u306e\u5206\u6ccc\u6291\u5236\u3084\u3001\u8edf\u9aa8\u5206\u89e3\u9175\u7d20\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a4\u30ca\u30fc\u30bc\u3001MMP\uff09\u306e\u963b\u5bb3\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002 \u3055\u3089\u306b\u3001I\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a2\u30b0\u30ea\u30ab\u30f3\u3068\u3044\u3063\u305f\u8edf\u9aa8\u69cb\u6210\u6210\u5206\u306e\u5408\u6210\u4fc3\u9032\u3082\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u5358\u306a\u308b\u75db\u307f\u306e\u7de9\u548c\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u69cb\u9020\u7684\u306a\u4fee\u5fa9\u52b9\u679c\u3082\u671f\u5f85\u3055\u308c\u308b\u70b9\u3067\u7279\u7b46\u306b\u5024\u3057\u307e\u3059\u3002 \u7b2c\u4e94\u7ae0\uff1a\u80a5\u6e80\u3068\u7cd6\u4ee3\u8b1d\u3078\u306e\u6311\u6226 \u2015 \u30c1\u30ea\u30ed\u30b7\u30c9\u306e\u9769\u547d \u73fe\u4ee3\u75c5\u306e\u8c61\u5fb4\u3068\u3082\u3044\u3048\u308b\u80a5\u6e80\u30682\u578b\u7cd6\u5c3f\u75c5\u3002\u305d\u306e\u80cc\u666f\u306b\u306f\u904e\u5270\u306a\u8102\u80aa\u84c4\u7a4d\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u9032\u884c\u304c\u3042\u308a\u307e\u3059\u3002\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u306e\u7a2e\u306b\u542b\u307e\u308c\u308b\u30c1\u30ea\u30ed\u30b7\u30c9\u306f\u3001\u307e\u3055\u306b\u3053\u306e\u4ee3\u8b1d\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u5e0c\u671b\u306e\u661f\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002 2015\u5e74\u306e\u30d2\u30c8\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08Nagatomo et al.\uff09\u3067\u306f\u3001BMI\u304c25\u301c30\u306e\u4e88\u5099\u80a5\u6e80\u800532\u540d\u3092\u5bfe\u8c61\u306b\u3001\u30ed\u30fc\u30ba\u30d2\u30c3\u30d7\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30ebEX\uff08\u30c1\u30ea\u30ed\u30b7\u30c90.1%\u672a\u6e80\u542b\u6709\uff09\u309212\u9031\u9593\u6295\u4e0e\u3057\u305f\u7d50\u679c\u3001\u5185\u81d3\u8102\u80aa\u9762\u7a4d\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u4f53\u91cd\u3084\u76ae\u4e0b\u8102\u80aa\u306b\u306f\u9855\u8457\u306a\u5909\u5316\u304c\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u526f\u4f5c\u7528\u306f\u306a\u304f\u3001\u5b89\u5168\u6027\u306e\u9ad8\u3055\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002 \u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u306f\u3055\u3089\u306b\u660e\u78ba\u306a\u4ee3\u8b1d\u6539\u5584\u52b9\u679c\u304c\u898b\u3089\u308c\u3066\u3044\u307e\u3059\u3002Goto\u3089\uff082012\uff09\u306e\u7814\u7a76\u3067\u306f\u3001\u30c1\u30ea\u30ed\u30b7\u30c9\u309221\u65e5\u9593\u7d4c\u53e3\u6295\u4e0e\u3057\u305f\u7d50\u679c\u3001\u8840\u4e2d\u30a4\u30f3\u30b9\u30ea\u30f3\u304c43%\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c26%\u6e1b\u5c11\u3057\u3001\u8102\u80aa\u9178\u4ee3\u8b1d\u3092\u4fc3\u9032\u3059\u308b\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\uff08Adiponectin\uff09\u304a\u3088\u3073\u305d\u306e\u9ad8\u5206\u5b50\u591a\u91cf\u4f53\uff08HMW 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