{"id":89,"date":"2025-06-06T02:02:17","date_gmt":"2025-06-06T02:02:17","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/diet\/?p=89"},"modified":"2025-08-12T08:50:19","modified_gmt":"2025-08-12T08:50:19","slug":"tirzepatide-obesity-diabetes-treatment-overview","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/diet\/tirzepatide-obesity-diabetes-treatment-overview\/","title":{"rendered":"\u6b21\u4e16\u4ee3\u306e\u80a5\u6e80\u30fb\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u300c\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u300d\uff1a\u4e8c\u91cd\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u4f5c\u52d5\u85ac\u304c\u3082\u305f\u3089\u3059\u9769\u65b0\u3068\u305d\u306e\u53ef\u80fd\u6027"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u5e8f\u8ad6\u304a\u3088\u3073\u80cc\u666f<\/strong><\/h2>\n\n\n\n<p>\u80a5\u6e80\u304a\u3088\u30732\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff1atype 2 diabetes mellitus\uff09\u306f\u3001\u4e16\u754c\u7684\u306b\u6700\u3082\u91cd\u5927\u306a\u516c\u8846\u885b\u751f\u8ab2\u984c\u306e\u4e00\u3064\u3067\u3042\u308a\u30012035\u5e74\u307e\u3067\u306b20\u5104\u4eba\u4ee5\u4e0a\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u3002\u80a5\u6e80\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\uff08CVD\uff1acardiovascular disease\uff09\u3001\u7cd6\u5c3f\u75c5\u3001\u304c\u3093\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5927\u304d\u304f\u9ad8\u3081\u3001\u4e16\u754c\u5168\u4f53\u3067\u5e74\u95934\u5146\u30c9\u30eb\u3092\u8d85\u3048\u308b\u7d4c\u6e08\u7684\u640d\u5931\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u5f93\u6765\u306e\u85ac\u7269\u7642\u6cd5\u306f\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u9650\u5b9a\u7684\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u8fd1\u5e74\u3067\u306f\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u30db\u30eb\u30e2\u30f3\u7d4c\u8def\u3001\u7279\u306bGLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff1aglucagon-like peptide-1\uff09\u304a\u3088\u3073GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\uff1aglucose-dependent insulinotropic polypeptide\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306b\u6ce8\u76ee\u304c\u96c6\u307e\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306e\u85ac\u7406\u5b66\u7684\u7279\u6027<\/strong><\/h2>\n\n\n\n<p>\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff08Tirzepatide, Mounjaro\u2122\uff09\u306f\u3001GLP-1\u304a\u3088\u3073GIP\u53d7\u5bb9\u4f53\u306e\u4e21\u65b9\u306b\u4f5c\u7528\u3059\u308b\u5408\u6210\u4e8c\u91cd\u4f5c\u52d5\u85ac\uff08dual agonist peptide\uff09\u3067\u3042\u308b\u3002\u69cb\u9020\u7684\u306b\u306f39\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308a\u3001C20\u8102\u80aa\u4e8c\u9178\uff08C20 fatty diacid\uff09\u3092\u4fee\u98fe\u306b\u52a0\u3048\u308b\u3053\u3068\u3067\u30a2\u30eb\u30d6\u30df\u30f3\u3068\u306e\u7d50\u5408\u529b\u3092\u9ad8\u3081\u3001\u8840\u4e2d\u534a\u6e1b\u671f\uff08\u7d04117\u6642\u9593\uff09\u3092\u8457\u3057\u304f\u5ef6\u9577\u3057\u3066\u3044\u308b\u3002GLP-1\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u89aa\u548c\u6027\u306f\u5929\u7136GLP-1\u306e\u7d0420%\u3067\u3042\u308b\u304c\u3001GIP\u53d7\u5bb9\u4f53\u306b\u5bfe\u3057\u3066\u306f\u5929\u7136GIP\u3068\u540c\u69d8\u306e\u6d3b\u6027\u3092\u793a\u3059\u3002\u85ac\u7269\u52d5\u614b\u5b66\u7684\u306b\u306f\u3001\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\uff08\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\uff09\u306f\u7d0481%\u3001\u6700\u9ad8\u8840\u4e2d\u6fc3\u5ea6\u5230\u9054\u6642\u9593\uff08Tmax\uff09\u306f12\uff5e96\u6642\u9593\u3067\u3042\u308a\u3001\u4ee3\u8b1d\u306f\u4e3b\u306b\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u7d4c\u8def\u3092\u4ecb\u3057\u3001CYP450\u9175\u7d20\u306e\u95a2\u4e0e\u306f\u306a\u3044\u3002\u809d\u6a5f\u80fd\u304a\u3088\u3073\u814e\u6a5f\u80fd\u969c\u5bb3\u306b\u3088\u308b\u5f71\u97ff\u3082\u6700\u5c0f\u9650\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f5c\u7528\u6a5f\u5e8f\uff08Mechanism of Action\uff09<\/strong><\/h2>\n\n\n\n<p>\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u8840\u7cd6\u4f9d\u5b58\u7684\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u5206\u6ccc\u3092\u6291\u5236\u3059\u308b\u3002\u307e\u305f\u3001GLP-1\u3068GIP\u306e\u4e8c\u91cd\u4f5c\u52d5\u306b\u3088\u308a\u3001\u7a7a\u8179\u6642\u304a\u3088\u3073\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4f4e\u4e0b\u3001\u98df\u6b32\u6291\u5236\u3001\u80c3\u6392\u51fa\u306e\u9045\u5ef6\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u9855\u8457\u306a\u4f53\u91cd\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u81e8\u5e8a\u7684\u6709\u52b9\u6027<\/strong><\/h2>\n\n\n\n<p>\u81e8\u5e8a\u8a66\u9a13\u306f\u4e3b\u306b\u300cSURPASS\uff082\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8840\u7cd6\u7ba1\u7406\uff09\u300d\u304a\u3088\u3073\u300cSURMOUNT\uff08\u4f53\u91cd\u7ba1\u7406\uff09\u300d\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u4e0b\u3067\u5b9f\u65bd\u3055\u308c\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SURMOUNT-1\u8a66\u9a13\uff08\u975e\u7cd6\u5c3f\u75c5\u5bfe\u8c61\uff09\uff1a\u30c1\u30eb\u30bc\u30d1\u30c1\u30c915mg\/\u9031\u6295\u4e0e\u306b\u3088\u308a\u3001\u30d7\u30e9\u30bb\u30dc\u306e3.1%\u306b\u5bfe\u3057\u6700\u592720.9%\u306e\u4f53\u91cd\u6e1b\u5c11\u3092\u9054\u6210\u3002<br><\/li>\n\n\n\n<li>SURMOUNT-2\u8a66\u9a13\uff08T2DM\u5bfe\u8c61\uff09\uff1a\u4f53\u91cd\u6e1b\u5c11\u306f\u6700\u592714.7%\u3002<br><\/li>\n\n\n\n<li>SURPASS\u8a66\u9a13\u7fa4\uff1aHbA1c\u306e\u9855\u8457\u306a\u4f4e\u4e0b\uff08\u6700\u592728.2 mmol\/mol\u3001\u7d042.6%\uff09\u3001\u304a\u3088\u3073\u4f53\u91cd\u6e1b\u5c11\uff085\u301c14%\uff09\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6cbb\u7642\u3084\u6295\u4e0e\u91cf\u306b\u4f9d\u5b58\u3057\u3066\u5909\u52d5\u3059\u308b\u3002<br><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4ed6\u85ac\u5264\u3068\u306e\u6bd4\u8f03\u6709\u52b9\u6027<\/strong><\/h2>\n\n\n\n<p>\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08Semaglutide\uff09\u3084\u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9\uff08Dulaglutide\uff09\u306a\u3069\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff08GLP-1 RAs: GLP-1 receptor agonists\uff09\u306b\u6bd4\u3079\u3066\u4e00\u8cab\u3057\u3066\u9ad8\u3044\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001SURPASS-2\u8a66\u9a13\u3067\u306f\u300115 mg\u306e\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u304c1 mg\u306e\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306b\u6bd4\u30796.6%\u591a\u304f\u4f53\u91cd\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u4ee3\u8b1d\u7684\u5229\u70b9<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8840\u5727\u6539\u5584\uff1a\u53ce\u7e2e\u671f\u8840\u5727\u30674.7\u201312.6 mmHg\u3001\u62e1\u5f35\u671f\u8840\u5727\u30670.8\u20135.6 mmHg\u306e\u4f4e\u4e0b\u3002<br><\/li>\n\n\n\n<li>\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u6539\u5584\uff1aLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u6700\u592719.3%\u6e1b\u5c11\uff09\u304a\u3088\u3073\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\uff08\u500b\u4eba\u5dee\u3042\u308a\uff09\u3002<br><\/li>\n\n\n\n<li>\u4f53\u7d44\u6210\u30fb\u809d\u8102\u80aa\uff1a\u4f53\u8102\u80aa\u7dcf\u91cf\u3067\u7d0426%\u3001\u809d\u8102\u80aa\u3067\u7d048.1%\u306e\u7d76\u5bfe\u7684\u6e1b\u5c11\u3002\u7b4b\u8089\u91cf\u306e\u6e1b\u5c11\u306f\u6700\u5c0f\u9650\u3002<br><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5b89\u5168\u6027\u304a\u3088\u3073\u526f\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4e00\u822c\u7684\u306a\u526f\u4f5c\u7528\uff08\u4e3b\u306b\u6d88\u5316\u5668\u7cfb\uff09<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5410\u304d\u6c17\uff0823\u201331%\uff09\u3001\u4e0b\u75e2\uff0819\u201323%\uff09\u3001\u5614\u5410\uff0812\u201313%\uff09\u304c\u591a\u304f\u5831\u544a\u3055\u308c\u308b\u304c\u3001\u591a\u304f\u306f\u4e00\u904e\u6027\u3067\u6295\u4e0e\u958b\u59cb\u5f8c\u6570\u65e5\u301c\u6570\u9031\u9593\u4ee5\u5185\u306b\u6539\u5584\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u91cd\u7be4\u306a\u526f\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5168\u4f53\u306e5\u20139%\u306b\u5831\u544a\u3055\u308c\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u3084\u3084\u9ad8\u7387\u3002<br><\/li>\n\n\n\n<li>\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc\u306f\u6297\u85ac\u7269\u6297\u4f53\uff08antidrug antibodies, ADA\uff09\u306e\u51fa\u73fe\u3068\u3084\u3084\u76f8\u95a2\u3059\u308b\uff08ADA\u967d\u6027\u7387\u306f51%\uff09\u304c\u3001\u81e8\u5e8a\u7684\u5f71\u97ff\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4f4e\u8840\u7cd6\uff08hypoglycemia\uff09<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5358\u72ec\u7642\u6cd5\u3067\u306f\u975e\u7cd6\u5c3f\u75c5\u3067&lt;2%\u3001\u7cd6\u5c3f\u75c5\u3067\u7d044%\u3068\u307e\u308c\u3060\u304c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3084\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u7cfb\u85ac\u3068\u306e\u4f75\u7528\u3067\u6700\u592719%\u306b\u5897\u52a0\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u307e\u308c\u3060\u304c\u91cd\u5927\u306a\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u81b5\u708e\uff1a\u30a2\u30df\u30e9\u30fc\u30bc\u304a\u3088\u3073\u30ea\u30d1\u30fc\u30bc\u306e\u4e0a\u6607\uff08\u6700\u5927\u7d0438%\uff09\u306f\u3042\u308b\u304c\u3001\u4ed6\u85ac\u5264\u3084\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u767a\u75c7\u30ea\u30b9\u30af\u306f\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u306a\u3044\u3002<br><\/li>\n\n\n\n<li>\u80c6\u56a2\u75be\u60a3\uff1a\u80c6\u77f3\u75c7\u30fb\u80c6\u56a2\u708e\u306e\u767a\u75c7\u7387\u306f\u7d040.6%\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30d6\u30e9\u30c3\u30af\u30dc\u30c3\u30af\u30b9\u8b66\u544a\uff1a\u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u30010.15 mg\/kg\u4ee5\u4e0a\u3067\u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d\u306e\u30ea\u30b9\u30af\u304c\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u4e0a\u6607\u3002\u30d2\u30c8\u3078\u306e\u5f71\u97ff\u306f\u4e0d\u660e\u3067\u3042\u308b\u304c\u3001\u7532\u72b6\u817a\u9ac4\u69d8\u764c\uff08MTC\uff1amedullary thyroid carcinoma\uff09\u307e\u305f\u306f\u591a\u767a\u6027\u5185\u5206\u6ccc\u816b\u760d\u75c72\u578b\uff08MEN 2\uff1aMultiple Endocrine Neoplasia type 2\uff09\u306e\u500b\u4eba\u30fb\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u60a3\u8005\u306b\u306f\u7981\u5fcc\u3002<br><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5206\u5b50\u30fb\u751f\u7406\u7684\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4e2d\u67a2\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>GLP-1\u53d7\u5bb9\u4f53\u306f\u8996\u5e8a\u4e0b\u90e8\u3084\u8133\u5e79\u306b\u5206\u5e03\u3057\u3001\u98df\u6b32\u304a\u3088\u3073\u6e80\u8179\u611f\u3092\u5236\u5fa1\u3002\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u5f13\u72b6\u6838\uff08arcuate nucleus\uff09\u3001\u5ef6\u9ac4\uff08NTS\uff1anucleus tractus solitarius\uff09\u3001\u304a\u3088\u3073\u4e2d\u8133\u8fba\u7e01\u7cfb\uff08\u5831\u916c\u7cfb\u30c9\u30fc\u30d1\u30df\u30f3\u7d4c\u8def\uff09\u306b\u4f5c\u7528\u3057\u3001\u6442\u98df\u884c\u52d5\u3092\u6291\u5236\u3002<br><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u672b\u68a2\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6d88\u5316\u7ba1\u30db\u30eb\u30e2\u30f3\u8abf\u7bc0\uff1a\u30b0\u30ec\u30ea\u30f3\u4f4e\u4e0b\u3001PYY\u304a\u3088\u3073CCK\u4e0a\u6607\u306b\u3088\u308a\u3001\u80c3\u6392\u51fa\u9045\u5ef6\u304a\u3088\u3073\u6e80\u8179\u611f\u5897\u5f37\u3002<br><\/li>\n\n\n\n<li>\u4ee3\u8b1d\u5236\u5fa1\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3068\u5206\u6ccc\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u306e\u6539\u5584\u3002\u30b0\u30eb\u30ab\u30b4\u30f3\u6291\u5236\u3002<br><\/li>\n\n\n\n<li>\u71b1\u7523\u751f\u30fb\u8102\u8cea\u5229\u7528\uff1a\u8910\u8272\u8102\u80aa\u7d44\u7e54\u306e\u6d3b\u6027\u5316\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u5897\u52a0\u306e\u53ef\u80fd\u6027\u3002<br><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u814e\u81d3\u30a2\u30a6\u30c8\u30ab\u30e0<\/strong><\/h2>\n\n\n\n<p>\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff1amajor adverse cardiovascular events\uff09\u306b\u5bfe\u3059\u308b\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306f\u7d040.80\u3068\u4e88\u5099\u7684\u306a\u5fc3\u8840\u7ba1\u4fdd\u8b77\u52b9\u679c\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306e\u5927\u898f\u6a21\u8a66\u9a13\uff08SURPASS-CVOT\u3001SURMOUNT-MMO\uff09\u304c\u9032\u884c\u4e2d\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u306b\u304a\u3051\u308b\u4f4d\u7f6e\u3065\u3051<\/strong><\/h2>\n\n\n\n<p>\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u51cc\u99d5\u3059\u308b\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304a\u3088\u3073\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u80a5\u6e80\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u304a\u3051\u308b\u65b0\u305f\u306a\u6642\u4ee3\u306e\u5230\u6765\u3092\u8c61\u5fb4\u3059\u308b\u3002\u4ee3\u8b1d\u75be\u60a3\u306e\u307f\u306a\u3089\u305a\u3001\u5fc3\u8840\u7ba1\u30fb\u814e\u75be\u60a3\u9818\u57df\u3078\u306e\u5fdc\u7528\u53ef\u80fd\u6027\u3082\u62e1\u5927\u3055\u305b\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u81e8\u5e8a\u4f7f\u7528\u30fb\u6295\u4e0e\u6307\u91dd<\/strong><\/h2>\n\n\n\n<p>\u521d\u56de\u306f2.5 mg\u3092\u90311\u56de\u76ae\u4e0b\u6ce8\u5c04\u3057\u3001\u5fcd\u5bb9\u6027\u3092\u898b\u306a\u304c\u30894\u9031\u9593\u3054\u3068\u306b2.5 mg\u305a\u3064\u5897\u91cf\u3057\u3001\u6700\u592715 mg\/\u9031\u307e\u3067\u6295\u4e0e\u53ef\u80fd\u3002\u81b5\u708e\u3001\u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d\u30ea\u30b9\u30af\u306e\u3042\u308b\u60a3\u8005\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\u60a3\u8005\uff08\u6d88\u5316\u5668\u75c7\u72b6\u306b\u3088\u308b\u8131\u6c34\u30ea\u30b9\u30af\uff09\u3001\u80c6\u56a2\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u60a3\u8005\u306b\u306f\u7279\u306b\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5c06\u6765\u5c55\u671b\u3068\u7814\u7a76\u8ab2\u984c<\/strong><\/h2>\n\n\n\n<p>\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308bSURPASS-CVOT\u3084\u5fc3\u4e0d\u5168\u3078\u306e\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308bSUMMIT\u8a66\u9a13\u304c\u9032\u884c\u4e2d\u3067\u3042\u308a\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306e\u5305\u62ec\u7684\u306a\u5fc3\u814e\u4ee3\u8b1d\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u4eca\u5f8c\u660e\u3089\u304b\u306b\u306a\u308b\u898b\u901a\u3057\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001GLP-1\u3001GIP\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u53d7\u5bb9\u4f53\u306e\u591a\u91cd\u6a19\u7684\u4f5c\u52d5\u85ac\uff08multi-agonists\uff09\u3082\u958b\u767a\u4e2d\u3067\u3042\u308a\u3001\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u306e\u63d0\u4f9b\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7d50\u8ad6<\/strong><\/h2>\n\n\n\n<p>\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff08\u30de\u30f3\u30b8\u30e3\u30ed\uff09\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u4f53\u91cd\u6e1b\u5c11\u306b\u304a\u3044\u3066\u9855\u8457\u306a\u52b9\u679c\u3092\u793a\u3059\u3002\u4e8c\u91cd\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u4f5c\u52d5\u6a5f\u69cb\u306b\u3088\u308a\u3001\u65e2\u5b58\u6cbb\u7642\u3092\u4e0a\u56de\u308b\u4ee3\u8b1d\u6539\u5584\u304c\u5f97\u3089\u308c\u3001\u4e3b\u306b\u4e00\u904e\u6027\u306e\u6d88\u5316\u5668\u75c7\u72b6\u306b\u3068\u3069\u307e\u308b\u826f\u597d\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6709\u3059\u308b\u3002\u4eca\u5f8c\u306e\u7814\u7a76\u306b\u3088\u308a\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u814e\u81d3\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u5168\u5bb9\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u3053\u3068\u3067\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u4ee3\u8b1d\u75be\u60a3\u6cbb\u7642\u306e\u4e2d\u6838\u7684\u5f79\u5272\u3092\u62c5\u3046\u5b58\u5728\u3068\u3057\u3066\u306e\u5730\u4f4d\u3092\u78ba\u56fa\u305f\u308b\u3082\u306e\u3068\u3059\u308b\u3067\u3042\u308d\u3046\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u306f\uff1f<\/h3>\n\n\n\n<p>\u30de\u30f3\u30b8\u30e3\u30ed\uff08\u4e00\u822c\u540d\uff1a\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff09\u306f\u3001\u7c73\u56fd\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u793e\u304c\u958b\u767a\u3057\u305f\u6ce8\u5c04\u578b\u306e\u65b0\u4e16\u4ee3\u6cbb\u7642\u85ac\u3067\u3001\u300c\u4e8c\u91cd\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u4f5c\u52d5\u85ac\u300d\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u7279\u5fb4\u306f\u3001GLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff09\u3068GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\uff09\u3068\u3044\u3046\u3001\u4e8c\u3064\u306e\u6d88\u5316\u7ba1\u30db\u30eb\u30e2\u30f3\u306e\u53d7\u5bb9\u4f53\u3092\u540c\u6642\u306b\u523a\u6fc0\u3067\u304d\u308b\u70b9\u3067\u3059\u3002GLP-1\u306f\u8133\u306e\u6e80\u8179\u4e2d\u67a2\u3092\u523a\u6fc0\u3057\u3066\u98df\u6b32\u3092\u6291\u3048\u308b\u307b\u304b\u3001\u80c3\u306e\u6392\u51fa\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u3067\u5c11\u91cf\u3067\u3082\u6e80\u8179\u611f\u3092\u6301\u7d9a\u3055\u305b\u307e\u3059\u3002\u4e00\u65b9\u3001GIP\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u3057\u3001\u8102\u80aa\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u6539\u5584\u306b\u3082\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u5f93\u6765\u306eGLP-1\u5358\u72ec\u4f5c\u52d5\u85ac\u3067\u306f\u5230\u9054\u3057\u306b\u304f\u304b\u3063\u305f\u300c\u3088\u308a\u5927\u304d\u306a\u4f53\u91cd\u6e1b\u5c11\u300d\u3068\u300c\u512a\u308c\u305f\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u300d\u3092\u3001\u4e8c\u3064\u306e\u4f5c\u7528\u306e\u76f8\u4e57\u52b9\u679c\u306b\u3088\u3063\u3066\u5b9f\u73fe\u53ef\u80fd\u306b\u3057\u307e\u3057\u305f\u3002\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u306e\u80cc\u666f\u306b\u306f\u5358\u306a\u308b\u30ab\u30ed\u30ea\u30fc\u904e\u591a\u3060\u3051\u3067\u306a\u304f\u3001\u8133\u30fb\u8178\u30fb\u81b5\u81d3\u306e\u8907\u96d1\u306a\u30b7\u30b0\u30ca\u30eb\u306e\u4e71\u308c\u304c\u3042\u308a\u307e\u3059\u3002\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u3001\u305d\u306e\u6839\u672c\u306b\u50cd\u304d\u304b\u3051\u308b\u3053\u3068\u3067\u3001\u9577\u671f\u7684\u306a\u4f53\u91cd\u7ba1\u7406\u3068\u4ee3\u8b1d\u6539\u5584\u3092\u540c\u6642\u306b\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u9769\u65b0\u7684\u306a\u85ac\u5264\u306a\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u52b9\u679c<\/h3>\n\n\n\n<p>\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u7cd6\u5c3f\u75c5\u60a3\u8005\u3060\u3051\u3067\u306a\u304f\u3001\u7cd6\u5c3f\u75c5\u3092\u6301\u305f\u306a\u3044\u80a5\u6e80\u306e\u4eba\u306b\u304a\u3044\u3066\u3082\u5927\u5e45\u306a\u4f53\u91cd\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u90311\u56de\u306e\u76ae\u4e0b\u6ce8\u5c04\u309272\u9031\u9593\u7d9a\u3051\u305f\u5834\u5408\u3001\u6700\u9ad8\u7528\u91cf\u3067\u306f\u5e73\u574720\uff05\u524d\u5f8c\u306e\u4f53\u91cd\u6e1b\u5c11\u304c\u5831\u544a\u3055\u308c\u3001\u5185\u81d3\u8102\u80aa\u306e\u6e1b\u5c11\u3084\u8840\u7cd6\u3001\u8840\u5727\u3001\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u6539\u5584\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u5916\u79d1\u7684\u306a\u6e1b\u91cf\u624b\u8853\u306b\u5339\u6575\u3059\u308b\u6210\u679c\u3067\u3042\u308a\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u4e88\u9632\u306e\u89b3\u70b9\u304b\u3089\u3082\u5927\u304d\u306a\u30a4\u30f3\u30d1\u30af\u30c8\u304c\u3042\u308a\u307e\u3059\u3002\u52a0\u3048\u3066\u3001GLP-1\u4f5c\u52d5\u85ac\u306b\u898b\u3089\u308c\u308b\u5410\u304d\u6c17\u3084\u6d88\u5316\u5668\u75c7\u72b6\u306e\u526f\u4f5c\u7528\u304c\u6bd4\u8f03\u7684\u8efd\u6e1b\u3055\u308c\u308b\u50be\u5411\u3082\u6307\u6458\u3055\u308c\u3066\u304a\u308a\u3001\u7d99\u7d9a\u3057\u3084\u3059\u3044\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u3082\u3046\u4e00\u3064\u306e\u6ce8\u76ee\u70b9\u306f\u3001\u8133\u306e\u5831\u916c\u7cfb\u306b\u3082\u4f5c\u7528\u3057\u300c\u98df\u3079\u305f\u3044\u300d\u3068\u3044\u3046\u885d\u52d5\u305d\u306e\u3082\u306e\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u5358\u306a\u308b\u77ed\u671f\u7684\u306a\u6e1b\u91cf\u3067\u306f\u306a\u304f\u3001\u98df\u7fd2\u6163\u305d\u306e\u3082\u306e\u306e\u6539\u5584\u3068\u9577\u671f\u7684\u306a\u4f53\u91cd\u7dad\u6301\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4eca\u5f8c\u306f\u598a\u5a20\u524d\u306e\u4f53\u91cd\u7ba1\u7406\u3084\u80a5\u6e80\u95a2\u9023\u5408\u4f75\u75c7\u306e\u4e88\u9632\u3001\u3055\u3089\u306b\u306f\u4ee3\u8b1d\u6539\u5584\u3092\u901a\u3058\u305f\u5065\u5eb7\u5bff\u547d\u5ef6\u4f38\u306a\u3069\u3001\u591a\u69d8\u306a\u5834\u9762\u3067\u306e\u5fdc\u7528\u304c\u898b\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.2147\/PPA.S419304\">Jensen, T. L., Br\u00f8nden, A., Karstoft, K., Sonne, D. P., &amp; Christensen, M. B. (2024). The Body weight Reducing Effects of Tirzepatide in People with and without Type 2 Diabetes: A Review on Efficacy and Adverse Effects. <em>Patient Preference and Adherence<\/em>, <em>18<\/em>, 373\u2013382. https:\/\/doi.org\/10.2147\/PPA.S419304<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/ijms25158202\">Nicze, Micha\u0142, et al. \u2018Molecular Mechanisms behind Obesity and Their Potential Exploitation in Current and Future Therapy\u2019. International Journal of Molecular Sciences, vol. 25, no. 15, July 2024, p. 8202. DOI.org (Crossref), https:\/\/doi.org\/10.3390\/ijms25158202.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2022\/215866Orig1s000lbl.pdf\">Center for Drug Evaluation and Research. (2022, May). <em>Mounjaro\u2122 (tirzepatide) injection, for subcutaneous use: Initial U.S. approval 2022<\/em> (Application No. 215866Orig1s000; Reference ID: 4983783). U.S. Food and Drug Administration. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2022\/215866Orig1s000lbl.pdf<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s40265-022-01746-8\">Syed, Y.Y. Tirzepatide: First Approval. <em>Drugs<\/em> 82, 1213\u20131220 (2022). https:\/\/doi.org\/10.1007\/s40265-022-01746-8<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/molecules27134315\">Chavda, Vivek P., et al. \u2018Tirzepatide, a New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review\u2019. Molecules, vol. 27, no. 13, July 2022, p. 4315. DOI.org (Crossref), https:\/\/doi.org\/10.3390\/molecules27134315.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1186\/s12933-024-02319-7\">Taktaz, F., Fontanella, R.A., Scisciola, L. <em>et al.<\/em> Bridging the gap between GLP1-receptor agonists and cardiovascular outcomes: evidence for the role of tirzepatide. <em>Cardiovasc Diabetol<\/em> 23, 242 (2024). https:\/\/doi.org\/10.1186\/s12933-024-02319-7<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.hsr.2022.100032\">Ali, Rouchan, et al. \u2018Bumps and Humps in the Success of Tirzepatide as the First GLP1 and GIP Receptor Agonist\u2019. Health Sciences Review, vol. 4, Sept. 2022, p. 100032. DOI.org (Crossref), https:\/\/doi.org\/10.1016\/j.hsr.2022.100032.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.amjmed.2025.01.021\">Moiz, Areesha, et al. \u2018Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation\u2019. The American Journal of Medicine, vol. 138, no. 6, June 2025, pp. 934\u201340. DOI.org (Crossref), https:\/\/doi.org\/10.1016\/j.amjmed.2025.01.021.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.7570\/jomes22067\">Sinha, Rachel, et al. \u2018Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management\u2019. Journal of Obesity &amp; Metabolic Syndrome, vol. 32, no. 1, Mar. 2023, pp. 25\u201345. DOI.org (Crossref), https:\/\/doi.org\/10.7570\/jomes22067.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1136\/bmjopen-2024-094947\">Sillassen, Christina Dam Bjerregaard, et al. \u2018Adverse Effects with Tirzepatide: A Protocol for a Systematic Review with Meta-Analysis and Trial Sequential Analysis\u2019. BMJ Open, vol. 15, no. 4, Apr. 2025, p. e094947. DOI.org (Crossref), https:\/\/doi.org\/10.1136\/bmjopen-2024-094947.<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/osp4.70032\">Kamrul\u2010Hasan, A. B. M., et al. \u2018Pancreatic Safety of Tirzepatide and Its Effects on Islet Cell Function: A Systematic Review and Meta\u2010Analysis\u2019. Obesity Science &amp; Practice, vol. 10, no. 6, Dec. 2024, p. e70032. DOI.org (Crossref), https:\/\/doi.org\/10.1002\/osp4.70032.<\/a><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5e8f\u8ad6\u304a\u3088\u3073\u80cc\u666f \u80a5\u6e80\u304a\u3088\u30732\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff1atype 2 diabetes mellitus\uff09\u306f\u3001\u4e16\u754c\u7684\u306b\u6700\u3082\u91cd\u5927\u306a\u516c\u8846\u885b\u751f\u8ab2\u984c\u306e\u4e00\u3064\u3067\u3042\u308a\u30012035\u5e74\u307e\u3067\u306b20\u5104\u4eba\u4ee5\u4e0a\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u3002\u80a5\u6e80\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\uff08CVD\uff1acardiovascular disease\uff09\u3001\u7cd6\u5c3f\u75c5\u3001\u304c\u3093\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5927\u304d\u304f\u9ad8\u3081\u3001\u4e16\u754c\u5168\u4f53\u3067\u5e74\u95934\u5146\u30c9\u30eb\u3092\u8d85\u3048\u308b\u7d4c\u6e08\u7684\u640d\u5931\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u5f93\u6765\u306e\u85ac\u7269\u7642\u6cd5\u306f\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u9650\u5b9a\u7684\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u8fd1\u5e74\u3067\u306f\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u30db\u30eb\u30e2\u30f3\u7d4c\u8def\u3001\u7279\u306bGLP-1\uff08\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff1aglucagon-like peptide-1\uff09\u304a\u3088\u3073GIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\uff1aglucose-dependent insulinotropic polypeptide\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306b\u6ce8\u76ee\u304c\u96c6\u307e\u3063\u3066\u3044\u308b\u3002 \u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306e\u85ac\u7406\u5b66\u7684\u7279\u6027 \u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff08Tirzepatide, Mounjaro\u2122\uff09\u306f\u3001GLP-1\u304a\u3088\u3073GIP\u53d7\u5bb9\u4f53\u306e\u4e21\u65b9\u306b\u4f5c\u7528\u3059\u308b\u5408\u6210\u4e8c\u91cd\u4f5c\u52d5\u85ac\uff08dual agonist peptide\uff09\u3067\u3042\u308b\u3002\u69cb\u9020\u7684\u306b\u306f39\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308a\u3001C20\u8102\u80aa\u4e8c\u9178\uff08C20 fatty diacid\uff09\u3092\u4fee\u98fe\u306b\u52a0\u3048\u308b\u3053\u3068\u3067\u30a2\u30eb\u30d6\u30df\u30f3\u3068\u306e\u7d50\u5408\u529b\u3092\u9ad8\u3081\u3001\u8840\u4e2d\u534a\u6e1b\u671f\uff08\u7d04117\u6642\u9593\uff09\u3092\u8457\u3057\u304f\u5ef6\u9577\u3057\u3066\u3044\u308b\u3002GLP-1\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u89aa\u548c\u6027\u306f\u5929\u7136GLP-1\u306e\u7d0420%\u3067\u3042\u308b\u304c\u3001GIP\u53d7\u5bb9\u4f53\u306b\u5bfe\u3057\u3066\u306f\u5929\u7136GIP\u3068\u540c\u69d8\u306e\u6d3b\u6027\u3092\u793a\u3059\u3002\u85ac\u7269\u52d5\u614b\u5b66\u7684\u306b\u306f\u3001\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\uff08\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\uff09\u306f\u7d0481%\u3001\u6700\u9ad8\u8840\u4e2d\u6fc3\u5ea6\u5230\u9054\u6642\u9593\uff08Tmax\uff09\u306f12\uff5e96\u6642\u9593\u3067\u3042\u308a\u3001\u4ee3\u8b1d\u306f\u4e3b\u306b\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u7d4c\u8def\u3092\u4ecb\u3057\u3001CYP450\u9175\u7d20\u306e\u95a2\u4e0e\u306f\u306a\u3044\u3002\u809d\u6a5f\u80fd\u304a\u3088\u3073\u814e\u6a5f\u80fd\u969c\u5bb3\u306b\u3088\u308b\u5f71\u97ff\u3082\u6700\u5c0f\u9650\u3067\u3042\u308b\u3002 \u4f5c\u7528\u6a5f\u5e8f\uff08Mechanism of Action\uff09 \u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u8840\u7cd6\u4f9d\u5b58\u7684\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u5206\u6ccc\u3092\u6291\u5236\u3059\u308b\u3002\u307e\u305f\u3001GLP-1\u3068GIP\u306e\u4e8c\u91cd\u4f5c\u52d5\u306b\u3088\u308a\u3001\u7a7a\u8179\u6642\u304a\u3088\u3073\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4f4e\u4e0b\u3001\u98df\u6b32\u6291\u5236\u3001\u80c3\u6392\u51fa\u306e\u9045\u5ef6\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u9855\u8457\u306a\u4f53\u91cd\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3059\u3002 \u81e8\u5e8a\u7684\u6709\u52b9\u6027 \u81e8\u5e8a\u8a66\u9a13\u306f\u4e3b\u306b\u300cSURPASS\uff082\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8840\u7cd6\u7ba1\u7406\uff09\u300d\u304a\u3088\u3073\u300cSURMOUNT\uff08\u4f53\u91cd\u7ba1\u7406\uff09\u300d\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u4e0b\u3067\u5b9f\u65bd\u3055\u308c\u3066\u3044\u308b\uff1a \u4ed6\u85ac\u5264\u3068\u306e\u6bd4\u8f03\u6709\u52b9\u6027 \u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08Semaglutide\uff09\u3084\u30c7\u30e5\u30e9\u30b0\u30eb\u30c1\u30c9\uff08Dulaglutide\uff09\u306a\u3069\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff08GLP-1 RAs: GLP-1 receptor agonists\uff09\u306b\u6bd4\u3079\u3066\u4e00\u8cab\u3057\u3066\u9ad8\u3044\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001SURPASS-2\u8a66\u9a13\u3067\u306f\u300115 mg\u306e\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u304c1 mg\u306e\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306b\u6bd4\u30796.6%\u591a\u304f\u4f53\u91cd\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002 \u8ffd\u52a0\u306e\u4ee3\u8b1d\u7684\u5229\u70b9 \u5b89\u5168\u6027\u304a\u3088\u3073\u526f\u4f5c\u7528 \u4e00\u822c\u7684\u306a\u526f\u4f5c\u7528\uff08\u4e3b\u306b\u6d88\u5316\u5668\u7cfb\uff09 \u91cd\u7be4\u306a\u526f\u4f5c\u7528 \u4f4e\u8840\u7cd6\uff08hypoglycemia\uff09 \u307e\u308c\u3060\u304c\u91cd\u5927\u306a\u30ea\u30b9\u30af \u30d6\u30e9\u30c3\u30af\u30dc\u30c3\u30af\u30b9\u8b66\u544a\uff1a\u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d \u5206\u5b50\u30fb\u751f\u7406\u7684\u4f5c\u7528\u6a5f\u5e8f \u4e2d\u67a2\u4f5c\u7528 \u672b\u68a2\u4f5c\u7528 \u5fc3\u8840\u7ba1\u304a\u3088\u3073\u814e\u81d3\u30a2\u30a6\u30c8\u30ab\u30e0 \u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff1amajor adverse cardiovascular events\uff09\u306b\u5bfe\u3059\u308b\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306f\u7d040.80\u3068\u4e88\u5099\u7684\u306a\u5fc3\u8840\u7ba1\u4fdd\u8b77\u52b9\u679c\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306e\u5927\u898f\u6a21\u8a66\u9a13\uff08SURPASS-CVOT\u3001SURMOUNT-MMO\uff09\u304c\u9032\u884c\u4e2d\u3067\u3042\u308b\u3002 \u6cbb\u7642\u306b\u304a\u3051\u308b\u4f4d\u7f6e\u3065\u3051 \u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306f\u3001\u5f93\u6765\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u51cc\u99d5\u3059\u308b\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304a\u3088\u3073\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u80a5\u6e80\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u304a\u3051\u308b\u65b0\u305f\u306a\u6642\u4ee3\u306e\u5230\u6765\u3092\u8c61\u5fb4\u3059\u308b\u3002\u4ee3\u8b1d\u75be\u60a3\u306e\u307f\u306a\u3089\u305a\u3001\u5fc3\u8840\u7ba1\u30fb\u814e\u75be\u60a3\u9818\u57df\u3078\u306e\u5fdc\u7528\u53ef\u80fd\u6027\u3082\u62e1\u5927\u3055\u305b\u3066\u3044\u308b\u3002 \u81e8\u5e8a\u4f7f\u7528\u30fb\u6295\u4e0e\u6307\u91dd \u521d\u56de\u306f2.5 mg\u3092\u90311\u56de\u76ae\u4e0b\u6ce8\u5c04\u3057\u3001\u5fcd\u5bb9\u6027\u3092\u898b\u306a\u304c\u30894\u9031\u9593\u3054\u3068\u306b2.5 mg\u305a\u3064\u5897\u91cf\u3057\u3001\u6700\u592715 mg\/\u9031\u307e\u3067\u6295\u4e0e\u53ef\u80fd\u3002\u81b5\u708e\u3001\u7532\u72b6\u817aC\u7d30\u80de\u816b\u760d\u30ea\u30b9\u30af\u306e\u3042\u308b\u60a3\u8005\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\u60a3\u8005\uff08\u6d88\u5316\u5668\u75c7\u72b6\u306b\u3088\u308b\u8131\u6c34\u30ea\u30b9\u30af\uff09\u3001\u80c6\u56a2\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u60a3\u8005\u306b\u306f\u7279\u306b\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u63a8\u5968\u3055\u308c\u308b\u3002 \u5c06\u6765\u5c55\u671b\u3068\u7814\u7a76\u8ab2\u984c \u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308bSURPASS-CVOT\u3084\u5fc3\u4e0d\u5168\u3078\u306e\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308bSUMMIT\u8a66\u9a13\u304c\u9032\u884c\u4e2d\u3067\u3042\u308a\u3001\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u306e\u5305\u62ec\u7684\u306a\u5fc3\u814e\u4ee3\u8b1d\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u4eca\u5f8c\u660e\u3089\u304b\u306b\u306a\u308b\u898b\u901a\u3057\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001GLP-1\u3001GIP\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u53d7\u5bb9\u4f53\u306e\u591a\u91cd\u6a19\u7684\u4f5c\u52d5\u85ac\uff08multi-agonists\uff09\u3082\u958b\u767a\u4e2d\u3067\u3042\u308a\u3001\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u306e\u63d0\u4f9b\u304c\u671f\u5f85\u3055\u308c\u308b\u3002 \u7d50\u8ad6 [&hellip;]<\/p>\n","protected":false},"author":23,"featured_media":162,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[20],"tags":[22,21,16,12,14,23,15],"class_list":["post-89","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-20","tag-22","tag-glp-1","tag-16","tag-12","tag-14","tag-23","tag-15"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\u3068\u306f\uff1f\u80a5\u6e80\u30fb\u7cd6\u5c3f\u75c5\u3078\u306e\u65b0\u6cbb\u7642\u306e\u5168\u8c8c\u3068\u5c55\u671b\uff5c\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af<\/title>\n<meta name=\"description\" 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