{"id":7667,"date":"2025-02-18T12:46:50","date_gmt":"2025-02-18T03:46:50","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/ed\/?p=7667"},"modified":"2025-02-21T15:54:00","modified_gmt":"2025-02-21T06:54:00","slug":"pdei_alzheimer","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/ed\/pdei_alzheimer\/","title":{"rendered":"ED\u3068AD\u2015\u52c3\u8d77\u4e0d\u5168\u85ac\u3067\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u3092\uff1f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u52c3\u8d77\u4e0d\u5168\u6cbb\u7642\u85ac\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">\u52c3\u8d77\u4e0d\u5168<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">ED<\/a>\uff1aErectile Dysfunction\uff09\u306e\u6cbb\u7642\u85ac\u306f\u3001\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u51e6\u65b9\u3055\u308c\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u304c\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff1aAlzheimer\u2019s Disease\uff09\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u56e0\u679c\u95a2\u4fc2\u304c\u8a3c\u660e\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u795e\u7d4c\u3092\u4fdd\u8b77\u3059\u308b\u52b9\u679c\uff08\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\uff09\u306e\u53ef\u80fd\u6027\u3092\u793a\u3057\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u30022024\u5e742\u67087\u65e5\u306b\u533b\u5b66\u8a8c\u300eNeurology\u300f\u306b\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u591a\u304f\u306e\u7537\u6027\u306e\u5065\u5eb7\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3001\u6709\u671b\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"451\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/908699_s-1.jpg\" alt=\"\u9320\u5264\u3092\u820c\u306b\" class=\"wp-image-7658\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/908699_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/908699_s-1-300x211.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/908699_s-1-485x342.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff1a\u306a\u305cED\u6cbb\u7642\u85ac\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4e88\u9632\u306b\u6ce8\u76ee\u3055\u308c\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u3001\u4e16\u754c\u4e2d\u3067\u6570\u5343\u4e07\u4eba\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u6700\u3082\u4e00\u822c\u7684\u306a\u8a8d\u77e5\u75c7\u306e\u4e00\u7a2e\u3067\u3059\u3002\u73fe\u5728\u306e\u3068\u3053\u308d\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u306f\u306a\u304f\u3001\u75c5\u6c17\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u305f\u308a\u3001\u767a\u75c7\u3092\u9045\u3089\u305b\u305f\u308a\u3059\u308b\u65b9\u6cd5\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u8133\u5185\u306b\u84c4\u7a4d\u3059\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u6591\uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u7279\u5fb4\u7684\u306a\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3092\u9664\u53bb\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u767a\u75c7\u3092\u9632\u3050\u624b\u6bb5\u306e\u78ba\u7acb\u3082\u6025\u52d9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30db\u30b9\u30db\u30b8\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc5\uff08PDE5\uff09\u963b\u5bb3\u85ac\u3068\u547c\u3070\u308c\u308b\u85ac\u5264\u306e\u4e00\u7a2e\u3067\u3042\u308b<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#sildenafil\">\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\uff08\u5546\u54c1\u540d\uff1a\u30d0\u30a4\u30a2\u30b0\u30e9\uff09\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#tadalafil\">\u30bf\u30c0\u30e9\u30d5\u30a3\u30eb<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#vardenafil\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\u306f\u3001\u3082\u3068\u3082\u3068\u9ad8\u8840\u5727\u3084\u72ed\u5fc3\u75c7\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u85ac\u306f\u3001\u8840\u7ba1\u3092\u62e1\u5f35\u3057\u8840\u6d41\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/\">ED\u6cbb\u7642<\/a>\u85ac\u3068\u3057\u3066\u306e\u7528\u9014\u304c\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8133\u306e\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u795e\u7d4c\u75be\u60a3\u3078\u306e\u52b9\u679c\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure class=\"wp-block-image size-large\"><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"256\" class=\"wp-image-7428\" src=\"\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp\" alt=\"\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp 1024w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-300x75.webp 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-768x192.webp 768w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-485x121.webp 485w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u5185\u5bb9\uff1aPDE5\u963b\u5bb3\u85ac\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af\u306e\u95a2\u4fc2<\/h2>\n\n\n\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u82f1\u56fd\u306e\u533b\u7642\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u300cIQVIA Medical Research Data UK\u300d\u306b\u8a18\u9332\u3055\u308c\u305f1,600\u4e07\u4eba\u4ee5\u4e0a\u306e\u5065\u5eb7\u60c5\u5831\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002\u5bfe\u8c61\u3068\u306a\u3063\u305f\u306e\u306f\u30012000\u5e74\u304b\u30892017\u5e74\u306e\u9593\u306b\u65b0\u305f\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">\u52c3\u8d77\u4e0d\u5168<\/a>\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">ED<\/a>\uff09\u3068\u8a3a\u65ad\u3055\u308c\u305f40\u6b73\u4ee5\u4e0a\u306e\u7537\u6027269,725\u4eba\u3067\u3001\u7814\u7a76\u958b\u59cb\u6642\u70b9\u3067\u306f\u3001\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u3084\u8a8d\u77e5\u75c7\u306e\u8a3a\u65ad\u3092\u53d7\u3051\u305f\u3053\u3068\u304c\u306a\u304f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u6cbb\u7642\u85ac\u3082\u670d\u7528\u3057\u3066\u3044\u306a\u3044\u4eba\u304c\u9078\u3070\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u8005\u306f\u3001PDE5\u963b\u5bb3\u85ac\uff08<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#sildenafil\">\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#tadalafil\">\u30bf\u30c0\u30e9\u30d5\u30a3\u30eb<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#vardenafil\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\uff09\u306e\u4f7f\u7528\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u7387\u306e\u95a2\u9023\u3092\u8abf\u67fb\u3057\u3001\u5e73\u57475\u5e74\u9593\u306b\u308f\u305f\u3063\u3066\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/5006270_s.jpg\" alt=\"\u5927\u4e8b\u306a\u304a\u4ed5\u4e8b\" class=\"wp-image-7679\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/5006270_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/5006270_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/5006270_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e3b\u306a\u7814\u7a76\u7d50\u679c<\/h2>\n\n\n\n<p>\u7814\u7a76\u671f\u9593\u4e2d\u306b\u30011,119\u4eba\u306e\u7537\u6027\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u767a\u75c7\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u767a\u75c7\u7387\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5dee\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PDE5\u963b\u5bb3\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u7387\u306f10,000\u4eba\u3042\u305f\u308a\u5e74\u95938.1\u4ef6<\/li>\n\n\n\n<li>PDE5\u963b\u5bb3\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u767a\u75c7\u7387\u306f10,000\u4eba\u3042\u305f\u308a\u5e74\u95939.7\u4ef6<\/li>\n<\/ul>\n\n\n\n<p>\u3064\u307e\u308a\u3001PDE5\u963b\u5bb3\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u670d\u7528\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u3079\u3066\u5e74\u959310,000\u4eba\u3042\u305f\u308a\u7d0416\u4ef6\u5c11\u306a\u3044\u767a\u75c7\u6570\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"725\" height=\"524\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/RplottakingPDE5iforAD.png\" alt=\"16%to18%\" class=\"wp-image-7670\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/RplottakingPDE5iforAD.png 725w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/RplottakingPDE5iforAD-300x217.png 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/RplottakingPDE5iforAD-485x351.png 485w\" sizes=\"auto, (max-width: 725px) 100vw, 725px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u5e74\u9f62\u3001\u55ab\u7159\u7fd2\u6163\u3001\u98f2\u9152\u91cf\u306a\u3069\u306e\u5f71\u97ff\u3092\u8abf\u6574\u3057\u305f\u7d50\u679c\u3001PDE5\u963b\u5bb3\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u305f\u7537\u6027\u306f\u3001\u670d\u7528\u3057\u3066\u3044\u306a\u3044\u7537\u6027\u306b\u6bd4\u3079\u3066\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c18%\u4f4e\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure class=\"wp-block-image size-large\"><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"256\" class=\"wp-image-7428\" src=\"\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp\" alt=\"\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp 1024w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-300x75.webp 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-768x192.webp 768w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-485x121.webp 485w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u7814\u7a76\u306e\u5f37\u307f\u3068\u9650\u754c<\/h3>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306e\u5f37\u307f\u3068\u3057\u3066\u3001\u5bfe\u8c61\u8005\u306e\u6570\u304c\u591a\u304f\u3001\u5927\u898f\u6a21\u306a\u533b\u7642\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u70b9\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u5065\u5eb7\u72b6\u614b\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u5f71\u97ff\u3092\u7d71\u8a08\u7684\u306b\u8abf\u6574\u3057\u306a\u304c\u3089\u5206\u6790\u3092\u884c\u3063\u305f\u305f\u3081\u3001\u7d50\u679c\u306e\u4fe1\u983c\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u85ac\u306e\u4f7f\u7528\u72b6\u6cc1\u3092\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u8003\u616e\u3059\u308b\u624b\u6cd5\u3092\u53d6\u308a\u5165\u308c\u305f\u3053\u3068\u3067\u3001\u30d0\u30a4\u30a2\u30b9\uff08\u504f\u308a\uff09\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u3044\u304f\u3064\u304b\u306e\u9650\u754c\u3082\u3042\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u306f\u51e6\u65b9\u8a18\u9332\u306b\u57fa\u3065\u3044\u3066\u304a\u308a\u3001\u60a3\u8005\u304c\u5b9f\u969b\u306b\u85ac\u3092\u670d\u7528\u3057\u305f\u304b\u3069\u3046\u304b\u306f\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u904b\u52d5\u7fd2\u6163\u3084\u98df\u751f\u6d3b\u3068\u3044\u3063\u305f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u5341\u5206\u306b\u8003\u616e\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u3053\u308c\u3089\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7814\u7a76\u5bfe\u8c61\u306f\u7537\u6027\u306e\u307f\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u5973\u6027\u306b\u5bfe\u3057\u3066\u3082\u540c\u69d8\u306e\u52b9\u679c\u304c\u3042\u308b\u306e\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"428\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/30061294_s.jpg\" alt=\"\u304a\u91ce\u83dc\" class=\"wp-image-7682\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/30061294_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/30061294_s-300x201.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/30061294_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u8005\u306e\u671f\u5f85<\/h2>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001PDE5\u963b\u5bb3\u85ac\u306e\u4f7f\u7528\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u95a2\u9023\u304c\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u56e0\u679c\u95a2\u4fc2\u304c\u8a3c\u660e\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u52b9\u679c\u306e\u6709\u7121\u3084\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3088\u308a\u660e\u78ba\u306b\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3055\u3089\u306b\u8a73\u7d30\u306a\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002\u7279\u306b\u3001\u7537\u6027\u3060\u3051\u3067\u306a\u304f\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u3092\u5b9f\u65bd\u3057\u3001\u85ac\u306e\u7528\u91cf\u3084\u5177\u4f53\u7684\u306a\u4e88\u9632\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u306e\u8cac\u4efb\u8457\u8005\u3067\u3042\u308b\u30ed\u30f3\u30c9\u30f3\u5927\u5b66\uff08University College London\uff09\u306e\u30eb\u30fc\u30b9\u30fb\u30d6\u30ed\u30a4\u30e4\u30fc\u535a\u58eb\u306f\u3001\u6b21\u306e\u3088\u3046\u306b\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u300c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u6591\u3092\u9664\u53bb\u3059\u308b\u65b0\u85ac\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u304c\u3001\u767a\u75c7\u3092\u4e88\u9632\u3059\u308b\u65b9\u6cd5\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u3082\u91cd\u8981\u3067\u3059\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u671f\u5f85\u304c\u6301\u3066\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u8a73\u3057\u304f\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u304c\u3042\u308a\u307e\u3059\u3002\u300d<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/31688111_s.jpg\" alt=\"\u671f\u5f85\u306f\u685c\u306e\u3088\u3046\u306b\u3001\u7dba\u9e97\u3067\u306f\u304b\u306a\u3044\" class=\"wp-image-7685\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31688111_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31688111_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31688111_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u6cbb\u7642\u306b\u304a\u3051\u308bPDE5\u963b\u5bb3\u85ac\u306e\u53ef\u80fd\u6027<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">PDE5\u963b\u5bb3\u85ac\u3068\u306f\uff1f<\/h3>\n\n\n\n<p>\u30db\u30b9\u30db\u30b8\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc5\uff08PDE5\uff09\u963b\u5bb3\u85ac\u306f\u3001\u74b0\u72b6\u30b0\u30a2\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178\uff08cGMP\uff09\u3068\u3044\u3046\u5206\u5b50\u306e\u30ec\u30d9\u30eb\u3092\u5897\u52a0\u3055\u305b\u308b\u85ac\u5264\u306e\u4e00\u7a2e\u3067\u3059\u3002cGMP\u306f\u8840\u7ba1\u306e\u5f1b\u7de9\u3092\u4fc3\u3057\u3001\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u85ac\u5264\u306f\u4e3b\u306b<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">\u52c3\u8d77\u4e0d\u5168<\/a>\u3084\u80ba\u9ad8\u8840\u5727\u75c7\u306e\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">PDE5\u963b\u5bb3\u85ac\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u95a2\u4fc2<\/h3>\n\n\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u3001cGMP\u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3057\u3001cGMP\u3092\u5206\u89e3\u3059\u308b\u30db\u30b9\u30db\u30b8\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc\u9175\u7d20\u306e\u6d3b\u6027\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002PDE5\u963b\u5bb3\u85ac\u304ccGMP\u30ec\u30d9\u30eb\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u30d0\u30e9\u30f3\u30b9\u306e\u5d29\u308c\u3092\u4fee\u6b63\u3057\u3001\u795e\u7d4c\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/1312304_s.jpg\" alt=\"\u8133\u30c8\u30ec\" class=\"wp-image-7691\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/1312304_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/1312304_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/1312304_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u52d5\u7269\u5b9f\u9a13\u3068\u81e8\u5e8a\u7814\u7a76\u306e\u7d50\u679c<\/h3>\n\n\n\n<p>\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u3001PDE5\u963b\u5bb3\u85ac\u304c\u8a8d\u77e5\u6a5f\u80fd\u306e\u6539\u5584\u3001\u8133\u8840\u6d41\u306e\u5411\u4e0a\u3001\u795e\u7d4c\u708e\u75c7\u306e\u6291\u5236\u3068\u3044\u3063\u305f\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#tadalafil\">\u30bf\u30c0\u30e9\u30d5\u30a3\u30eb<\/a>\u304c\u8133\u306e\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u7814\u7a76\u9593\u3067\u7d50\u679c\u306b\u4e00\u8cab\u6027\u304c\u306a\u304f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">\u52c3\u8d77\u4e0d\u5168<\/a>\u4ee5\u5916\u306e\u6cbb\u7642\u52b9\u679c\u3092\u78ba\u7acb\u3059\u308b\u306b\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u9032\u884c\u3068\u8840\u6d41\u306e\u95a2\u4fc2<\/h3>\n\n\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u521d\u671f\u5146\u5019\u306e\u4e00\u3064\u306b\u3001\u8133\u8840\u6d41\u306e\u4f4e\u4e0b\u304c\u3042\u308a\u307e\u3059\u3002\u8133\u5185\u306e\u6bdb\u7d30\u8840\u7ba1\u304c\u53ce\u7e2e\u3057\u3001\u8840\u6d41\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3067\u3001\u795e\u7d4c\u7d30\u80de\u3078\u306e\u9178\u7d20\u3084\u6804\u990a\u4f9b\u7d66\u304c\u4e0d\u8db3\u3057\u307e\u3059\u3002\u3053\u306e\u53ce\u7e2e\u306f\u3001\u30da\u30ea\u30b5\u30a4\u30c8\uff08\u8840\u6d41\u3092\u8abf\u7bc0\u3059\u308b\u7d30\u80de\uff09\u306e\u904e\u5270\u306a\u53ce\u7e2e\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u8133\u306b\u306f\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3068\u3044\u3046\u6709\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3057\u307e\u3059\u304c\u3001\u3053\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u304c\u30da\u30ea\u30b5\u30a4\u30c8\u306e\u53ce\u7e2e\u3092\u5f15\u304d\u8d77\u3053\u3059\u8981\u56e0\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u597d\u4e2d\u7403\u306e\u8840\u7ba1\u5185\u3067\u306e\u6ede\u7559\u3084\u8840\u6813\u306e\u5f62\u6210\u304c\u8133\u306e\u8840\u6d41\u3092\u4e00\u5c64\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3082\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8840\u6d41\u969c\u5bb3\u306f\u3001BACE1\u3068\u3044\u3046\u9175\u7d20\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u307b\u304b\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7570\u5e38\u306a\u4fee\u98fe\u3092\u52a9\u9577\u3057\u3001\u8133\u6a5f\u80fd\u3092\u3055\u3089\u306b\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u8133\u8840\u6d41\u306e\u4f4e\u4e0b\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/355588_s.jpg\" alt=\"\u5fc3\u81d3\u8840\u7ba1\u7cfb\" class=\"wp-image-7694\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/355588_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/355588_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/355588_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u8840\u6d41\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u95a2\u4fc2<\/h3>\n\n\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3084\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u3001\u8133\u8840\u6d41\u306e\u4f4e\u4e0b\u3068\u30d6\u30c9\u30a6\u7cd6\u4ee3\u8b1d\u306e\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30d6\u30c9\u30a6\u7cd6\u306f\u8133\u306e\u4e3b\u8981\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3067\u3042\u308a\u3001\u3053\u306e\u4ee3\u8b1d\u7570\u5e38\u306f\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u304c\u6df1\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u308bApoE4\u3092\u6301\u3064\u4eba\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u5909\u5316\u304c\u3088\u308a\u9855\u8457\u306b\u73fe\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8133\u306e\u7279\u5b9a\u306e\u9818\u57df\u3067\u306f\u8840\u6d41\u304c50%\u4ee5\u4e0a\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u3053\u308c\u304c\u30ca\u30c8\u30ea\u30a6\u30e0\u30fb\u30ab\u30ea\u30a6\u30e0\u30dd\u30f3\u30d7\uff08Na\/K\u30dd\u30f3\u30d7\uff09\u306e\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002\u3053\u306e\u30dd\u30f3\u30d7\u306f\u7d30\u80de\u5185\u5916\u306e\u30a4\u30aa\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3057\u3001\u5927\u91cf\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3059\u308b\u305f\u3081\u3001\u8840\u6d41\u4f4e\u4e0b\u306b\u3088\u308b\u5f71\u97ff\u3092\u7279\u306b\u53d7\u3051\u3084\u3059\u3044\u306e\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u8840\u6d41\u4e0d\u8db3\u306f\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306e\u8abf\u7bc0\u7570\u5e38\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u50cd\u304d\u3092\u640d\u306a\u3046\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8840\u6d41\u4f4e\u4e0b\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u521d\u671f\u6bb5\u968e\u304b\u3089\u898b\u3089\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u8840\u7ba1\u306e\u5065\u5eb7\u72b6\u614b\u304c\u75c5\u6c17\u306e\u9032\u884c\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u5b9f\u969b\u3001\u8840\u6d41\u304c20%\u4f4e\u4e0b\u3059\u308b\u3068\u6ce8\u610f\u529b\u304c\u4f4e\u4e0b\u3057\u300130%\u4f4e\u4e0b\u3059\u308b\u3068\u7a7a\u9593\u8a18\u61b6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"480\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/25173391_s.jpg\" alt=\"\u624b\u898b\u3048\u308b\u8840\u7ba1\" class=\"wp-image-7700\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/25173391_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/25173391_s-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/25173391_s-485x364.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">PDE5\u963b\u5bb3\u85ac\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u6cbb\u7642\u306b\u5f79\u7acb\u3064\u306e\u304b\uff1f<\/h2>\n\n\n\n<p>PDE5\u963b\u5bb3\u85ac\u306f\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ee3\u8868\u7684\u306aPDE5\u963b\u5bb3\u85ac\u306b\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#sildenafil\">\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#vardenafil\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#tadalafil\">\u30bf\u30c0\u30e9\u30d5\u30a3\u30eb<\/a>\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002\u4fdd\u967a\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u5927\u898f\u6a21\u306a\u89e3\u6790\u3067\u306f\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#sildenafil\">\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\u306e\u4f7f\u7528\u8005\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8a3a\u65ad\u30ea\u30b9\u30af\u304c69%\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001PDE5\u963b\u5bb3\u85ac\u306f\u3001\u8a18\u61b6\u5f62\u6210\u306b\u91cd\u8981\u306a\u9577\u671f\u5897\u5f37\uff08long-term potentiation\uff09\u3092\u4fc3\u9032\u3057\u3001\u5b66\u7fd2\u306b\u95a2\u4e0e\u3059\u308bCREB\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u307b\u304b\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u84c4\u7a4d\u3092\u6291\u5236\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/23504209_s.jpg\" alt=\"\u8133\u30c8\u30ec\uff12\" class=\"wp-image-7703\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/23504209_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/23504209_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/23504209_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u8ab2\u984c\u3068\u9650\u754c<\/h3>\n\n\n\n<p>\u6709\u671b\u306a\u7d50\u679c\u304c\u3042\u308b\u4e00\u65b9\u3067\u3001PDE5\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u306b\u306f\u8ab2\u984c\u3082\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#tadalafil\">\u30bf\u30c0\u30e9\u30d5\u30a3\u30eb<\/a>\u306f\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u904e\u3057\u306b\u304f\u3044\u305f\u3081\u3001\u8133\u5185\u3078\u306e\u5230\u9054\u304c\u9650\u3089\u308c\u307e\u3059\u3002PDE9\u963b\u5bb3\u85ac\u3082cGMP\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u304c\u3001\u30d2\u30c8\u3067\u306e\u8a8d\u77e5\u6a5f\u80fd\u5411\u4e0a\u306f\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u81e8\u5e8a\u7814\u7a76\u306e\u7d50\u679c\u3082\u4e00\u8cab\u3057\u3066\u304a\u3089\u305a\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#sildenafil\">\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\u306f\u5065\u5eb7\u306a\u6210\u4eba\u3084\u7d71\u5408\u5931\u8abf\u75c7\u60a3\u8005\u306e\u8a8d\u77e5\u6a5f\u80fd\u3092\u5411\u4e0a\u3055\u305b\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3067\u306f\u8133\u8840\u6d41\u3068\u9178\u7d20\u6d88\u8cbb\u304c\u5897\u52a0\u3057\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#vardenafil\">\u30d0\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\u3084\u30a6\u30c7\u30ca\u30d5\u30a3\u30eb\u306e\u8a66\u9a13\u3067\u306f\u3001\u6ce8\u610f\u529b\u3084\u4f5c\u696d\u8a18\u61b6\u306e\u6539\u5584\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3082\u306e\u306e\u3001\u5927\u898f\u6a21\u8a66\u9a13\u3067\u306e\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">PDE\u963b\u5bb3\u85ac\u306e\u5e45\u5e83\u3044\u53ef\u80fd\u6027<\/h3>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001cGMP\u3060\u3051\u3067\u306a\u304f\u3001\u74b0\u72b6\u30a2\u30c7\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178\uff08cAMP\uff09\u3082\u540c\u6642\u306b\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5927\u304d\u306a\u8a8d\u77e5\u6a5f\u80fd\u5411\u4e0a\u304c\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002PDE4\u3068PDE5\u306e\u963b\u5bb3\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u8a18\u61b6\u306e\u6539\u5584\u52b9\u679c\u304c\u52d5\u7269\u5b9f\u9a13\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"405\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/3345095_s.jpg\" alt=\"\u52c9\u5f37\u529b\uff12\" class=\"wp-image-7706\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/3345095_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/3345095_s-300x190.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/3345095_s-485x307.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u8840\u7ba1\u5065\u5eb7\u3078\u306e\u5f71\u97ff<\/h3>\n\n\n\n<p>PDE\u963b\u5bb3\u85ac\u306f\u8840\u7ba1\u306e\u5f1b\u7de9\u3092\u4fc3\u3057\u3001\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3067\u8133\u306e\u8840\u6d41\u8abf\u7bc0\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/pde5inhibitor\/#sildenafil\">\u30b7\u30eb\u30c7\u30ca\u30d5\u30a3\u30eb<\/a>\u306f\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u3092\u6539\u5584\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u8133\u306e\u9178\u7d20\u4ee3\u8b1d\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6<\/h2>\n\n\n\n<p>PDE\u963b\u5bb3\u85ac\u306f\u3001\u8840\u6d41\u6539\u5584\u3084\u795e\u7d4c\u53ef\u5851\u6027\u306e\u4fc3\u9032\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3084\u30bf\u30a6\u306e\u75c5\u7406\u3078\u306e\u5f71\u97ff\u3092\u901a\u3058\u3066\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6700\u9069\u306a\u6295\u4e0e\u6226\u7565\u306e\u78ba\u7acb\u3084\u3001\u5927\u898f\u6a21\u306a\u81e8\u5e8a\u8a66\u9a13\u306e\u5b9f\u65bd\u304c\u4eca\u5f8c\u306e\u8ab2\u984c\u3068\u306a\u308a\u307e\u3059\u3002\u73fe\u6642\u70b9\u3067\u306f\u3001PDE\u963b\u5bb3\u85ac\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u6cbb\u7642\u306b\u5e83\u304f\u5fdc\u7528\u3055\u308c\u308b\u306b\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/31517718_s.jpg\" alt=\"\u4ecb\u8b77\u306f\u5927\u4e8b\" class=\"wp-image-7709\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31517718_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31517718_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31517718_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure class=\"wp-block-image size-large\"><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"256\" class=\"wp-image-7428\" src=\"\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp\" alt=\"\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp 1024w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-300x75.webp 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-768x192.webp 768w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-485x121.webp 485w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1212\/WNL.0000000000209131\">Adesuyan, M., Jani, Y. H., Alsugeir, D., Howard, R., Ju, C., Wei, L., &amp; Brauer, R. (2024). Phosphodiesterase type 5 inhibitors in men with erectile dysfunction and the risk of alzheimer disease: A cohort study. <em>Neurology<\/em>, <em>102<\/em>(4), e209131. https:\/\/doi.org\/10.1212\/WNL.0000000000209131<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s00401-020-02215-w\">Korte, N., Nortley, R. &amp; Attwell, D. Cerebral blood flow decrease as an early pathological mechanism in Alzheimer&#8217;s disease. <em>Acta Neuropathol<\/em> 140, 793\u2013810 (2020). https:\/\/doi.org\/10.1007\/s00401-020-02215-w<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.11.022\">Tropea, M. R., Gulisano, W., Vacanti, V., Arancio, O., Puzzo, D., &amp; Palmeri, A. (2022). Nitric oxide\/cGMP\/CREB pathway and amyloid-beta crosstalk: From physiology to Alzheimer\u2019s disease. <em>Free Radical Biology and Medicine<\/em>, <em>193<\/em>, 657\u2013668. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.11.022<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3390\/ph14010061\">Fedele, E., &amp; Ricciarelli, R. (2021). Memory enhancers for alzheimer\u2019s dementia: Focus on cgmp. <em>Pharmaceuticals<\/em>, <em>14<\/em>(1), 61. https:\/\/doi.org\/10.3390\/ph14010061<\/a><\/li>\n<\/ul>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure class=\"wp-block-image size-large\"><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"256\" class=\"wp-image-7428\" src=\"\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp\" alt=\"\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp 1024w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-300x75.webp 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-768x192.webp 768w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-485x121.webp 485w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u52c3\u8d77\u4e0d\u5168\u6cbb\u7642\u85ac\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u306e\u304b\uff1f \u52c3\u8d77\u4e0d\u5168\uff08ED\uff1aErectile Dysfunction\uff09\u306e\u6cbb\u7642\u85ac\u306f\u3001\u8840\u6d41\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u51e6\u65b9\u3055\u308c\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u304c\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u85ac\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff1aAlzheimer\u2019s Disease\uff09\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u56e0\u679c\u95a2\u4fc2\u304c\u8a3c\u660e\u3055\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u795e\u7d4c\u3092\u4fdd\u8b77\u3059\u308b\u52b9\u679c\uff08\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\uff09\u306e\u53ef\u80fd\u6027\u3092\u793a\u3057\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u30022024\u5e742\u67087\u65e5\u306b\u533b\u5b66\u8a8c\u300eNeurology\u300f\u306b\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u591a\u304f\u306e\u7537\u6027\u306e\u5065\u5eb7\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3001\u6709\u671b\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002 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