{"id":8007,"date":"2025-02-21T14:48:14","date_gmt":"2025-02-21T05:48:14","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/ed\/?p=8007"},"modified":"2025-02-21T15:49:26","modified_gmt":"2025-02-21T06:49:26","slug":"genetics-and-ed","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/ed\/genetics-and-ed\/","title":{"rendered":"\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u304d\u660e\u304b\u3059\u52c3\u8d77\u4e0d\u5168\uff1a\u795e\u7d4c\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3046\u3064\u75c5\u3068\u306e\u95a2\u9023"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u52c3\u8d77\u4e0d\u5168\u306e\u907a\u4f1d\u7684\u304a\u3088\u3073\u795e\u7d4c\u751f\u7269\u5b66\u7684\u6d1e\u5bdf<\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">\u52c3\u8d77\u4e0d\u5168<\/a>\uff08Erectile Dysfunction\u3001<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">ED<\/a>\uff09\u306f\u3001\u6e80\u8db3\u306e\u3044\u304f\u6027\u4ea4\u306e\u305f\u3081\u306b\u5341\u5206\u306a\u52c3\u8d77\u3092\u9054\u6210\u307e\u305f\u306f\u7dad\u6301\u3067\u304d\u306a\u3044\u3053\u3068\u3092\u7279\u5fb4\u3068\u3059\u308b\u7537\u6027\u306e\u4e00\u822c\u7684\u306a\u6027\u7684\u969c\u5bb3\u3067\u3042\u308b\u3002\u52a0\u9f62\u3068\u3068\u3082\u306b\u767a\u75c7\u7387\u304c\u5897\u52a0\u3057\u30012025\u5e74\u307e\u3067\u306b\u4e16\u754c\u3067\u7d043\u51042200\u4e07\u4eba\u306e\u7537\u6027\u304cED\u3092\u7d4c\u9a13\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u3002ED\u306e\u767a\u75c7\u306b\u306f\u8907\u6570\u306e\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3001\u5668\u8cea\u7684\u8981\u56e0\uff08\u8840\u7ba1\u7cfb\u3084\u795e\u7d4c\u7cfb\u306e\u7570\u5e38\uff09\u3001\u5fc3\u56e0\u7684\u8981\u56e0\uff08\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u4e0d\u5b89\u306a\u3069\uff09\u3001\u307e\u305f\u306f\u305d\u306e\u4e21\u65b9\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u5206\u985e\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"480\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/3825870_s.jpg\" alt=\"\u67af\u308c\u305f\" class=\"wp-image-7858\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/3825870_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/3825870_s-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/3825870_s-485x364.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u52c3\u8d77\u4e0d\u5168\u306e\u907a\u4f1d\u7684\u57fa\u76e4<\/h2>\n\n\n\n<p>\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u306b\u3088\u308a\u3001ED\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u8abf\u67fb\u3055\u308c\u3066\u3044\u308b\u3002\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790\uff08Genome-Wide Association Study\u3001GWAS\uff09\u3067\u306f\u3001\u591a\u6570\u306e\u500b\u4f53\u306eDNA\u5168\u4f53\uff08\u30b2\u30ce\u30e0\uff09\u3092\u30b9\u30ad\u30e3\u30f3\u3057\u3001\u7279\u5b9a\u306e\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u5909\u7570\u3092\u7279\u5b9a\u3059\u308b\u3002\u3053\u306e\u624b\u6cd5\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u3088\u308a\u3001ED\u306b\u95a2\u9023\u3059\u308b17\u306e\u907a\u4f1d\u5b50\u304c\u540c\u5b9a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u591a\u304f\u306f\u3001\u4ee3\u8b1d\uff08\u751f\u547d\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u5316\u5b66\u30d7\u30ed\u30bb\u30b9\uff09\u3001\u795e\u7d4c\u5909\u6027\uff08\u795e\u7d4c\u7d30\u80de\u306e\u69cb\u9020\u3084\u6a5f\u80fd\u306e\u9032\u884c\u6027\u306e\u55aa\u5931\uff09\u3001\u304a\u3088\u3073\u30db\u30eb\u30e2\u30f3\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u6b63\u5e38\u306a\u52c3\u8d77\u6a5f\u80fd\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u76f8\u4e92\u4f5c\u7528\u89e3\u6790\uff08\u7d30\u80de\u5185\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3069\u306e\u3088\u3046\u306b\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u751f\u7269\u5b66\u7684\u6a5f\u80fd\u3092\u679c\u305f\u3059\u304b\u3092\u8abf\u67fb\u3059\u308b\u624b\u6cd5\uff09\u3067\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3059\u308b<span class=\"pre--maker span-stk-maker-yellow\"> INSR\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\uff09<\/span>\u907a\u4f1d\u5b50\u304a\u3088\u3073<span class=\"pre--maker span-stk-maker-yellow\"> LPL\uff08\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30d1\u30fc\u30bc\uff09<\/span>\u907a\u4f1d\u5b50\u304cED\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff08\u7d30\u80de\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u9069\u5207\u306b\u53cd\u5fdc\u3057\u306a\u3044\u72b6\u614b\uff09\u306f\u7cd6\u5c3f\u75c5\u306b\u3088\u304f\u898b\u3089\u308c\u3001\u8840\u7ba1\u640d\u50b7\u3084\u9670\u830e\u3078\u306e\u8840\u6d41\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001ED\u3092\u60aa\u5316\u3055\u305b\u308b\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u907a\u4f1d\u7684\u591a\u578b\uff08DNA\u914d\u5217\u306e\u5909\u7570\u306b\u3088\u308b\u907a\u4f1d\u5b50\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\uff09\u3082ED\u306e\u500b\u5225\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002<span class=\"pre--maker span-stk-maker-yellow\">\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50\uff08Vascular Endothelial Growth Factor\u3001VEGF\uff09<\/span>\u907a\u4f1d\u5b50\u306ers699947\u3001rs1570360\u3001rs2010963\u306a\u3069\u306e\u5909\u7570\u306f\u8840\u7ba1\u65b0\u751f\uff08\u65b0\u3057\u3044\u8840\u7ba1\u306e\u5f62\u6210\uff09\u304a\u3088\u3073\u4fee\u5fa9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002\u7279\u306b1155AA\u30b8\u30a7\u30ce\u30bf\u30a4\u30d7\u306f\u3001\u8840\u7ba1\u306e\u62e1\u5f35\u30fb\u53ce\u7e2e\u6a5f\u80fd\uff08\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\uff09\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3067ED\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001<span class=\"pre--maker span-stk-maker-yellow\">\u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff08Endothelial Nitric Oxide Synthase\u3001eNOS\uff09<\/span>\u907a\u4f1d\u5b50\u306eT786C\u30014VNTR\u3001G894T\u5909\u7570\u3082\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u306e\u7523\u751f\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u8840\u7ba1\u62e1\u5f35\u304a\u3088\u3073\u52c3\u8d77\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u4ed6\u3001ED\u306b\u95a2\u9023\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306b\u306f\u3001<span class=\"pre--maker span-stk-maker-yellow\">ACTG1\uff08\u7d30\u80de\u9aa8\u683c\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3059\u308b\u30a2\u30af\u30c1\u30f3\uff09<\/span>\u3001<span class=\"pre--maker span-stk-maker-yellow\">COL1A1\uff08\u7d44\u7e54\u69cb\u9020\u3092\u5f62\u6210\u3059\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\uff09<\/span>\u3001<span class=\"pre--maker span-stk-maker-yellow\">SIM1\uff08\u8996\u5e8a\u4e0b\u90e8\u306e\u6027\u6a5f\u80fd\u8abf\u7bc0\u306b\u95a2\u4e0e\uff09<\/span>\u3001<span class=\"pre--maker span-stk-maker-yellow\">TNF-\u03b1\uff08\u708e\u75c7\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff09<\/span>\u3001<span class=\"pre--maker span-stk-maker-yellow\">IGF-1\uff08\u8840\u7ba1\u306e\u5065\u5eb7\u7dad\u6301\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b50-1\uff09<\/span>\u3001<span class=\"pre--maker span-stk-maker-yellow\">CLDN5\uff08\u8840\u7ba1\u5185\u76ae\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5236\u5fa1\u3059\u308b\u30af\u30ed\u30fc\u30c7\u30a3\u30f3-5\uff09<\/span>\u3001\u304a\u3088\u3073<span class=\"pre--maker span-stk-maker-yellow\">TBC1D1\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3068\u795e\u7d4c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\uff09<\/span>\u304c\u542b\u307e\u308c\u308b\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/31974029_s-1.jpg\" alt=\"\u5065\u5eb7\" class=\"wp-image-7894\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31974029_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31974029_s-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31974029_s-1-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u3046\u3064\u75c5\u306e\u907a\u4f1d\u7684\u57fa\u76e4\u3068ED\u3068\u306e\u95a2\u9023<\/h2>\n\n\n\n<p>\u3046\u3064\u75c5\u306f\u4e16\u754c\u4e2d\u3067\u6570\u767e\u4e07\u4eba\u304c\u7f79\u60a3\u3059\u308b\u7cbe\u795e\u75be\u60a3\u3067\u3042\u308a\u3001ED\u3068\u306e\u95a2\u9023\u304c\u983b\u7e41\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u3046\u3064\u75c5\u306f\u6027\u6b32\u306e\u4f4e\u4e0b\u3001\u899a\u9192\u969c\u5bb3\u3001\u795e\u7d4c\u8840\u7ba1\u53cd\u5fdc\u306e\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001ED\u3092\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u9006\u306b\u3001ED\u306e\u5b58\u5728\u304c\u5fc3\u7406\u7684\u306a\u5065\u5eb7\u3092\u60aa\u5316\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u3046\u3064\u75c5\u3092\u5897\u5f37\u3059\u308b\u60aa\u5faa\u74b0\u3092\u5f62\u6210\u3059\u308b\u3002<\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u3088\u308a\u3001\u3046\u3064\u75c5\u306b\u95a2\u4e0e\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u304cED\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"pre--maker span-stk-maker-yellow\">SLC6A4\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff09<\/span>\uff1a\u30bb\u30ed\u30c8\u30cb\u30f3\u306f\u6c17\u5206\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3067\u3042\u308a\u3001SLC6A4\u306e\u767a\u73fe\u7570\u5e38\u306f\u3046\u3064\u75c5\u75c7\u72b6\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3002\u307e\u305f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306f\u6027\u7684\u8208\u596e\u306b\u3082\u95a2\u4e0e\u3057\u3001\u305d\u306e\u7570\u5e38\u306fED\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><span class=\"pre--maker span-stk-maker-yellow\">BDNF\uff08Brain-Derived Neurotrophic Factor\u3001\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09<\/span>\uff1a\u795e\u7d4c\u7d30\u80de\u306e\u751f\u5b58\u3084\u53ef\u5851\u6027\u3092\u8abf\u7bc0\u3057\u3001\u3046\u3064\u75c5\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3059\u308bVal66Met\u5909\u7570\u304cED\u30ea\u30b9\u30af\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><span class=\"pre--maker span-stk-maker-yellow\">COMT\uff08Catechol-O-Methyltransferase\u3001\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09<\/span>\uff1a\u30c9\u30fc\u30d1\u30df\u30f3\u4ee3\u8b1d\u3092\u5236\u5fa1\u3057\u3001\u6027\u7684\u6b32\u6c42\u3084\u52c3\u8d77\u53cd\u5fdc\u306b\u3082\u95a2\u4e0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><span class=\"pre--maker span-stk-maker-yellow\">NR3C1\uff08\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff09<\/span>\u304a\u3088\u3073<span class=\"pre--maker span-stk-maker-yellow\">FKBP5\uff08\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u8abf\u7bc0\uff09<\/span>\uff1a\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u7570\u5e38\u306b\u3088\u308a\u3001\u8840\u7ba1\u6a5f\u80fd\u969c\u5bb3\u3084NO\u306e\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001ED\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/31518350_s.jpg\" alt=\"\u7acb\u3066\u307e\u305b\u3093\" class=\"wp-image-7637\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31518350_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31518350_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31518350_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\uff1aED\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/h2>\n\n\n\n<p>\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u9244\u4f9d\u5b58\u6027\u306e\u7d30\u80de\u6b7b\u3067\u3042\u308a\u3001\u8102\u8cea\u904e\u9178\u5316\uff08\u8102\u8cea\u306e\u9178\u5316\u7684\u5206\u89e3\uff09\u306b\u3088\u308b\u7d30\u80de\u819c\u640d\u50b7\u304c\u7279\u5fb4\u3067\u3042\u308b\u3002<span class=\"pre--maker span-stk-maker-yellow\">GPX4\uff08\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc4\uff09<\/span>\u3001<span class=\"pre--maker span-stk-maker-yellow\">SLC7A11\uff08\u30bd\u30ea\u30e5\u30fc\u30c8\u30ad\u30e3\u30ea\u30a2\u30d5\u30a1\u30df\u30ea\u30fc7\uff09<\/span>\u3001<span class=\"pre--maker span-stk-maker-yellow\">ACSL4\uff08\u9577\u9396\u30a2\u30b7\u30eb-CoA\u5408\u6210\u9175\u7d204\uff09<\/span>\u306e\u907a\u4f1d\u5b50\u306f\u3001\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u6027<a href=\"https:\/\/www.hiro-clinic.or.jp\/ed\/\">\u52c3\u8d77\u4e0d\u5168<\/a>\uff08Diabetic Erectile Dysfunction\u3001DMED\uff09\u306e\u52d5\u7269\u5b9f\u9a13\u30e2\u30c7\u30eb\uff08\u30e9\u30c3\u30c8\u30e2\u30c7\u30eb\uff09\u3067\u306f\u3001\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u963b\u5bb3\u5264Fer-1\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001ED\u304c\u6539\u5584\u3055\u308c\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/26721726_s.jpg\" alt=\"\u30e9\u30c3\u30c8\u30e2\u30c7\u30eb\" class=\"wp-image-8028\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/26721726_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/26721726_s-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/26721726_s-485x324.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6<\/h2>\n\n\n\n<p>ED\u306f\u3001\u8840\u7ba1\u6a5f\u80fd\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001\u30d5\u30a7\u30ed\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3084\u591a\u578b\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308b\u8907\u96d1\u306a\u75be\u60a3\u3067\u3042\u308b\u3002\u8fd1\u5e74\u306e\u30b2\u30ce\u30e0\u7814\u7a76\u306b\u3088\u308a\u3001ED\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u3001\u7cbe\u5bc6\u533b\u7642\uff08Precision Medicine\uff09\u306e\u5b9f\u73fe\u306b\u5411\u3051\u305f\u907a\u4f1d\u5b50\u8a3a\u65ad\u304a\u3088\u3073\u500b\u5225\u5316\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"482\" src=\"\/ed\/wp-content\/uploads\/2025\/02\/31783897_s.jpg\" alt=\"\u5bcc\u58eb\u5c71\" class=\"wp-image-8025\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31783897_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31783897_s-300x226.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/02\/31783897_s-485x365.jpg 485w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure class=\"wp-block-image size-large\"><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"256\" class=\"wp-image-7428\" src=\"\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp\" alt=\"\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp 1024w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-300x75.webp 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-768x192.webp 768w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-485x121.webp 485w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1186\/s43042-024-00624-0\">Liu, M., Yu, M., Ma, Z. <em>et al.<\/em> Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction. <em>Egypt J Med Hum Genet<\/em> <strong>25<\/strong>, 151 (2024). https:\/\/doi.org\/10.1186\/s43042-024-00624-0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fendo.2023.1221043\">Yuan, P., Chen, Y., Sun, T., Cui, L., Wei, Y., Li, T., &amp; Meng, Q. (2023). Exploring potential genes and mechanisms linking erectile dysfunction and depression. <em>Frontiers in Endocrinology<\/em>, <em>14<\/em>, 1221043. https:\/\/doi.org\/10.3389\/fendo.2023.1221043<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.3389\/fgene.2022.1026227\">Ma, K., Song, P., Liu, Z., Yang, L., Wang, L., Zhou, J., Chen, J., &amp; Dong, Q. (2022). Genetic evidence suggests that depression increases the risk of erectile dysfunction: A Mendelian randomization study. <em>Frontiers in Genetics<\/em>, <em>13<\/em>, 1026227. https:\/\/doi.org\/10.3389\/fgene.2022.1026227<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1177\/03000605221100334\">Hong, Z., Chen, Z., Feng, J., Wang, S., Qiu, J., Zeng, Y., Wang, Q., &amp; Wang, J. (2022). Mechanistic analysis of erectile dysfunction in a depression rat model. <em>Journal of International Medical Research<\/em>, <em>50<\/em>(5), 03000605221100334. https:\/\/doi.org\/10.1177\/03000605221100334<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/bib\/bbaa338\">Kazemi, E., Zargooshi, J., Kaboudi, M., Heidari, P., Kahrizi, D., Mahaki, B., Mohammadian, Y., Khazaei, H., &amp; Ahmed, K. (2021). A genome-wide association study to identify candidate genes for erectile dysfunction. <em>Briefings in Bioinformatics<\/em>, <em>22<\/em>(4), bbaa338. https:\/\/doi.org\/10.1093\/bib\/bbaa338<\/a><\/li>\n<\/ul>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><figure class=\"wp-block-image size-large\"><a href=\"https:\/\/mypage-online-reservation.hiro-clinic.or.jp\/register\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"256\" class=\"wp-image-7428\" src=\"\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp\" alt=\"\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-1024x256.webp 1024w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-300x75.webp 300w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-768x192.webp 768w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01-485x121.webp 485w, https:\/\/www.hiro-clinic.or.jp\/ed\/wp-content\/uploads\/2025\/01\/banner-ed-cta-01.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><br \/>\n<\/a><\/figure>\n<\/div>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u52c3\u8d77\u4e0d\u5168\u306e\u907a\u4f1d\u7684\u304a\u3088\u3073\u795e\u7d4c\u751f\u7269\u5b66\u7684\u6d1e\u5bdf \u52c3\u8d77\u4e0d\u5168\uff08Erectile Dysfunction\u3001ED\uff09\u306f\u3001\u6e80\u8db3\u306e\u3044\u304f\u6027\u4ea4\u306e\u305f\u3081\u306b\u5341\u5206\u306a\u52c3\u8d77\u3092\u9054\u6210\u307e\u305f\u306f\u7dad\u6301\u3067\u304d\u306a\u3044\u3053\u3068\u3092\u7279\u5fb4\u3068\u3059\u308b\u7537\u6027\u306e\u4e00\u822c\u7684\u306a\u6027\u7684\u969c\u5bb3\u3067\u3042\u308b\u3002\u52a0\u9f62\u3068\u3068\u3082\u306b\u767a\u75c7\u7387\u304c\u5897\u52a0\u3057\u30012025\u5e74\u307e\u3067\u306b\u4e16\u754c\u3067\u7d043\u51042200\u4e07\u4eba\u306e\u7537\u6027\u304cED\u3092\u7d4c\u9a13\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u3002ED\u306e\u767a\u75c7\u306b\u306f\u8907\u6570\u306e\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3001\u5668\u8cea\u7684\u8981\u56e0\uff08\u8840\u7ba1\u7cfb\u3084\u795e\u7d4c\u7cfb\u306e\u7570\u5e38\uff09\u3001\u5fc3\u56e0\u7684\u8981\u56e0\uff08\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u4e0d\u5b89\u306a\u3069\uff09\u3001\u307e\u305f\u306f\u305d\u306e\u4e21\u65b9\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u5206\u985e\u3055\u308c\u308b\u3002 \u52c3\u8d77\u4e0d\u5168\u306e\u907a\u4f1d\u7684\u57fa\u76e4 \u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u306b\u3088\u308a\u3001ED\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u8abf\u67fb\u3055\u308c\u3066\u3044\u308b\u3002\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790\uff08Genome-Wide Association 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