{"id":16707,"date":"2026-01-20T00:31:50","date_gmt":"2026-01-20T00:31:50","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?post_type=genetic-screening&#038;p=16707"},"modified":"2026-01-20T00:31:50","modified_gmt":"2026-01-20T00:31:50","slug":"16p13-3-duplication-syndrome","status":"publish","type":"genetic-screening","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/genetic-screening\/16p13-3-duplication-syndrome\/","title":{"rendered":"16p13.3 duplication syndrome"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u5225\u540d\u30fb\u95a2\u9023\u75be\u60a3\u540d<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>16p13.3\u91cd\u8907\u75c7\u5019\u7fa4<\/li>\n\n\n\n<li>16p13.3\u5fae\u7d30\u91cd\u8907\u75c7\u5019\u7fa4\uff0816p13.3 microduplication syndrome\uff09<\/li>\n\n\n\n<li>CREBBP\u91cd\u8907\u75c7\u5019\u7fa4\uff08CREBBP duplication syndrome\uff09<\/li>\n\n\n\n<li>\u90e8\u5206\u7684\u30c8\u30ea\u30bd\u30df\u30fc16p13.3\uff08Partial trisomy 16p13.3\uff09<\/li>\n\n\n\n<li>16p13.3\u30b3\u30d4\u30fc\u6570\u5909\u7570\uff08\u91cd\u8907\uff09\uff0816p13.3 copy number variant, duplication\uff09<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5bfe\u8c61\u67d3\u8272\u4f53\u9818\u57df<\/strong><\/h2>\n\n\n\n<p><strong>16\u756a\u67d3\u8272\u4f53 \u77ed\u8155\uff08p\uff0913.3\u9818\u57df<\/strong><\/p>\n\n\n\n<p>\u672c\u75be\u60a3\u306f\u300116\u756a\u67d3\u8272\u4f53\u306e\u6700\u3082\u672b\u7aef\uff08\u30c6\u30ed\u30e1\u30a2\u5074\uff09\u306b\u4f4d\u7f6e\u3059\u308b\u300c13.3\u300d\u30d0\u30f3\u30c9\u306b\u304a\u3044\u3066\u3001DNA\u914d\u5217\u306e\u4e00\u90e8\u304c\u91cd\u8907\uff08\u30b3\u30d4\u30fc\u6570\u304c\u901a\u5e38\u306e2\u672c\u304b\u30893\u672c\u306b\u5897\u52a0\uff09\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u751f\u3058\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u9818\u57df\u306f\u907a\u4f1d\u5b50\u5bc6\u5ea6\u304c\u975e\u5e38\u306b\u9ad8\u3044\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u91cd\u8907\u306e\u7bc4\u56f2\u306b\u3088\u3063\u3066\u542b\u307e\u308c\u308b\u907a\u4f1d\u5b50\u306e\u6570\u304c\u7570\u306a\u308a\u307e\u3059\u304c\u3001\u75be\u60a3\u306e\u4e3b\u8981\u306a\u539f\u56e0\u3068\u306a\u308b\u306e\u306fCREBBP\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3010\u9818\u57df\u306e\u907a\u4f1d\u5b66\u7684\u7279\u5fb4\u3011<\/p>\n\n\n\n<p>16p13.3\u9818\u57df\u306f\u3001\u67d3\u8272\u4f53\u306e\u69cb\u9020\u4e0a\u3001\u907a\u4f1d\u5b50\u306e\u6b20\u5931\u3084\u91cd\u8907\u304c\u751f\u3058\u3084\u3059\u3044\u300c\u30db\u30c3\u30c8\u30b9\u30dd\u30c3\u30c8\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u7a00\u306b\u767a\u751f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u9818\u57df\u306e\u300c\u6b20\u5931\uff08deletion\uff09\u300d\u306f\u3001\u6709\u540d\u306a\u300cRubinstein-Taybi\u75c7\u5019\u7fa4\uff08\u30eb\u30d3\u30f3\u30b7\u30e5\u30bf\u30a4\u30f3\u30fb\u30c6\u30a4\u30d3\u75c7\u5019\u7fa4\uff09\u300d\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u672c\u75be\u60a3\u306f\u305d\u306e\u300c\u9006\uff08reciprocal\uff09\u300d\u306e\u72b6\u614b\u3067\u3042\u308a\u3001\u540c\u3058\u907a\u4f1d\u5b50\u304c\u5897\u3048\u308b\u3053\u3068\u3067\u5168\u304f\u7570\u306a\u308b\u3001\u3057\u304b\u3057\u91cd\u7be4\u306a\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8cac\u4efb\u907a\u4f1d\u5b50\uff08CREBBP\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li><em>CREBBP<\/em>\uff08CREB binding protein\uff09\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u5185\u3067\u4ed6\u306e\u591a\u304f\u306e\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u8abf\u7bc0\u3059\u308b\u300c\u8ee2\u5199\u5171\u5f79\u56e0\u5b50\u300d\u3068\u3044\u3046\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u6b20\u5931\u3059\u308b\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u8db3\u308a\u306a\u304f\u306a\u308a\uff08\u30cf\u30d7\u30ed\u4e0d\u5168\uff09\u3001\u91cd\u8907\u3059\u308b\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u904e\u5270\u306b\u306a\u308a\u307e\u3059\uff08\u907a\u4f1d\u5b50\u91cf\u52b9\u679c\uff09\u3002\u3069\u3061\u3089\u306e\u5834\u5408\u3082\u3001\u8133\u3084\u4f53\u306e\u6b63\u5e38\u306a\u767a\u751f\u30d7\u30ed\u30bb\u30b9\u304c\u963b\u5bb3\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u4ed6\u306b\u3082<em>DNASE1<\/em>\u3084<em>TRAP1<\/em>\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u542b\u307e\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u75c7\u72b6\u3078\u306e\u5bc4\u4e0e\u5ea6\u306f<em>CREBBP<\/em>\u304c\u6700\u3082\u5927\u304d\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u767a\u751f\u983b\u5ea6<\/strong><\/h2>\n\n\n\n<p><strong>\u975e\u5e38\u306b\u7a00\uff08Very Rare\uff09<\/strong><\/p>\n\n\n\n<p>16p13.3\u6b20\u5931\u75c7\u5019\u7fa4\uff08Rubinstein-Taybi\u75c7\u5019\u7fa4\uff09\u306b\u6bd4\u3079\u308b\u3068\u3001\u3053\u306e\u91cd\u8907\u75c7\u5019\u7fa4\u306e\u5831\u544a\u6570\u306f\u3055\u3089\u306b\u5c11\u306a\u304f\u3001\u5e0c\u5c11\u75be\u60a3\u306e\u4e2d\u3067\u3082\u7279\u306b\u7a00\u306a\u90e8\u985e\u306b\u5165\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6b63\u78ba\u306a\u7d71\u8a08\u7684\u983b\u5ea6\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u4e16\u754c\u3067\u306e\u5831\u544a\u4f8b\u306f\u6570\u5341\u4f8b\u301c\u767e\u4f8b\u7a0b\u5ea6\u306e\u898f\u6a21\uff08\u6587\u732e\u30ec\u30d9\u30eb\uff09\u3067\u3042\u308a\u3001100\u4e07\u4eba\u306b1\u4eba\u672a\u6e80\u306e\u983b\u5ea6\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u8a3a\u65ad\u6280\u8853\uff08\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u691c\u67fb\uff09\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u3053\u308c\u307e\u3067\u539f\u56e0\u4e0d\u660e\u3068\u3055\u308c\u3066\u3044\u305f\u77e5\u7684\u969c\u5bb3\u3084\u5148\u5929\u7570\u5e38\u306e\u60a3\u8005\u3055\u3093\u306e\u4e2d\u304b\u3089\u767a\u898b\u3055\u308c\u308b\u30b1\u30fc\u30b9\u304c\u5897\u3048\u3066\u304a\u308a\u3001\u5b9f\u969b\u306e\u983b\u5ea6\u306f\u3082\u3046\u5c11\u3057\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u81e8\u5e8a\u7684\u7279\u5fb4\uff08\u75c7\u72b6\uff09<\/strong><\/h2>\n\n\n\n<p>16p13.3\u91cd\u8907\u75c7\u5019\u7fa4\u306e\u75c7\u72b6\u306f\u3001\u60a3\u8005\u3055\u3093\u306b\u3088\u3063\u3066\u7a0b\u5ea6\u306b\u5dee\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u300c\u7279\u5fb4\u7684\u306a\u9854\u8c8c\u300d\u300c\u624b\u8db3\u306e\u6307\u306e\u7570\u5e38\u300d\u300c\u77e5\u7684\u969c\u5bb3\u300d\u306e3\u3064\u304c\u4e2d\u6838\u7684\u306a\u7279\u5fb4\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u624b\u8db3\u306e\u7279\u5fb4\u306f\u3001\u540c\u3058\u9818\u57df\u306e\u6b20\u5931\u3067\u3042\u308bRubinstein-Taybi\u75c7\u5019\u7fa4\uff08\u5e45\u5e83\u306e\u89aa\u6307\uff09\u3068\u306f\u5bfe\u7167\u7684\u3067\u3042\u308a\u3001\u8a3a\u65ad\u306e\u91cd\u8981\u306a\u624b\u304c\u304b\u308a\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u624b\u6307\u30fb\u56db\u80a2\u306e\u7279\u5fb4\uff08Arthrogryposis \/ Camptodactyly\uff09<\/strong><\/p>\n\n\n\n<p>\u672c\u75be\u60a3\u306b\u304a\u3044\u3066\u6700\u3082\u7279\u5fb4\u7684\u3067\u898b\u5206\u3051\u3084\u3059\u3044\u75c7\u72b6\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9577\u304f\u7d30\u3044\u6307\uff08Arachnodactyly\uff09:<\/strong> \u304f\u3082\u72b6\u6307\u3068\u3082\u547c\u3070\u308c\u3001\u6307\u304c\u7d30\u9577\u3044\u5f62\u72b6\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5c48\u66f2\u6307\uff08Camptodactyly\uff09:<\/strong> \u6307\u306e\u95a2\u7bc0\uff08\u7279\u306b\u8fd1\u4f4d\u6307\u7bc0\u9593\u95a2\u7bc0\uff09\u304c\u66f2\u304c\u3063\u305f\u307e\u307e\u4f38\u3073\u306b\u304f\u3044\u72b6\u614b\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u89aa\u6307\u306e\u7570\u5e38:<\/strong> Rubinstein-Taybi\u75c7\u5019\u7fa4\u3067\u306f\u300c\u5e45\u5e83\u3067\u77ed\u3044\u89aa\u6307\u300d\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u91cd\u8907\u75c7\u5019\u7fa4\u3067\u306f\u300c\u8fd1\u4f4d\u4ed8\u7740\uff08Proximally placed thumb\uff09\u300d\u3068\u3044\u3063\u3066\u3001\u89aa\u6307\u306e\u4ed8\u3051\u6839\u304c\u624b\u9996\u306b\u8fd1\u3044\u4f4d\u7f6e\u306b\u3042\u308a\u3001\u89aa\u6307\u81ea\u4f53\u3082\u7d30\u9577\u3044\u5f62\u72b6\u3092\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u95a2\u7bc0\u62d8\u7e2e\uff08Arthrogryposis\uff09:<\/strong> \u751f\u307e\u308c\u3064\u304d\u8907\u6570\u306e\u95a2\u7bc0\u304c\u56fa\u307e\u3063\u3066\u52d5\u304d\u306b\u304f\u3044\u72b6\u614b\uff08\u591a\u767a\u6027\u95a2\u7bc0\u62d8\u7e2e\uff09\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u624b\u9996\u3084\u8db3\u9996\u306e\u53ef\u52d5\u57df\u5236\u9650\u3092\u4f34\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5185\u53cd\u8db3:<\/strong> \u8db3\u306e\u88cf\u304c\u5185\u5074\u3092\u5411\u3044\u3066\u3044\u308b\u72b6\u614b\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u7279\u5fb4\u7684\u306a\u9854\u8c8c\uff08Craniofacial features\uff09<\/strong><\/p>\n\n\n\n<p>\u9854\u3064\u304d\u306b\u3082\u5171\u901a\u3057\u305f\u7279\u5fb4\u304c\u898b\u3089\u308c\u307e\u3059\u304c\u3001\u6210\u9577\u3068\u3068\u3082\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u982d\u84cb\u5f62\u72b6:<\/strong> \u9577\u982d\uff08\u982d\u304c\u524d\u5f8c\u306b\u9577\u3044\uff09\u3084\u3001\u524d\u982d\u90e8\uff08\u304a\u3067\u3053\uff09\u306e\u7a81\u51fa\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u5c0f\u982d\u75c7\u3092\u4f34\u3046\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u76ee:<\/strong> \u773c\u77bc\u88c2\uff08\u76ee\u306e\u6a2a\u5e45\uff09\u304c\u72ed\u3044\u3001\u773c\u77bc\u4e0b\u5782\uff08\u307e\u3076\u305f\u304c\u4e0b\u304c\u3063\u3066\u3044\u308b\uff09\u3001\u773c\u9593\u958b\u96e2\uff08\u76ee\u304c\u96e2\u308c\u3066\u3044\u308b\uff09\u3001\u6df1\u3044\u773c\u7aa9\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u9f3b:<\/strong> \u9f3b\u6839\u90e8\uff08\u9f3b\u306e\u4ed8\u3051\u6839\uff09\u304c\u5e45\u5e83\u304f\u3001\u9f3b\u5148\u304c\u4e38\u3044\uff08\u7403\u6839\u72b6\uff09\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u53e3\u5143:<\/strong> \u4e0a\u5507\u304c\u8584\u3044\u3001\u53e3\u84cb\u88c2\u3084\u53e3\u84cb\u9ad8\u30a2\u30fc\u30c1\uff08\u53e3\u306e\u4e2d\u306e\u5929\u4e95\u304c\u9ad8\u3044\uff09\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8033:<\/strong> \u8033\u306e\u4f4d\u7f6e\u304c\u4f4e\u3044\uff08\u4f4e\u4f4d\u4ed8\u7740\u8033\uff09\u3001\u8033\u306e\u5f62\u304c\u3044\u3073\u3064\u3067\u3042\u308b\u306a\u3069\u306e\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u795e\u7d4c\u767a\u9054\u30fb\u7cbe\u795e\u9045\u6ede<\/strong><\/p>\n\n\n\n<p>\u307b\u307c\u5168\u4f8b\u3067\u4e2d\u7b49\u5ea6\u304b\u3089\u91cd\u5ea6\u306e\u5f71\u97ff\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u77e5\u7684\u969c\u5bb3\uff08ID\uff09:<\/strong> \u591a\u304f\u306e\u30b1\u30fc\u30b9\u3067\u4e2d\u7b49\u5ea6\u301c\u91cd\u5ea6\u306e\u77e5\u7684\u969c\u5bb3\u3092\u4f34\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u767a\u9054\u9045\u6ede:<\/strong> \u9996\u3059\u308f\u308a\u3084\u304a\u5ea7\u308a\u306a\u3069\u306e\u904b\u52d5\u767a\u9054\u3001\u8a00\u8449\u306e\u7406\u89e3\u3084\u8868\u51fa\u306b\u304a\u3044\u3066\u9855\u8457\u306a\u9045\u308c\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u7279\u306b\u8a00\u8449\u304c\u51fa\u306a\u3044\uff08Non-verbal\uff09\u304b\u3001\u5358\u8a9e\u306e\u307f\u306e\u767a\u8a9e\u306b\u3068\u3069\u307e\u308b\u30b1\u30fc\u30b9\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u7b4b\u7dca\u5f35\u4f4e\u4e0b\uff08Hypotonia\uff09:<\/strong> \u4e73\u5150\u671f\u306b\u306f\u4f53\u304c\u67d4\u3089\u304b\u304f\u3001\u54fa\u4e73\u529b\u304c\u5f31\u3044\uff08\u30df\u30eb\u30af\u3092\u5438\u3046\u529b\u304c\u5f31\u3044\uff09\u3053\u3068\u304c\u591a\u304f\u3001\u6210\u9577\u306b\u4f34\u3063\u3066\u7b4b\u7dca\u5f35\u304c\u9ad8\u307e\u308b\uff08\u75d9\u6027\uff09\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>4. \u6210\u9577\u30fb\u6804\u990a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6210\u9577\u969c\u5bb3:<\/strong> \u51fa\u751f\u6642\u306e\u8eab\u9577\u30fb\u4f53\u91cd\u306f\u6b63\u5e38\u7bc4\u56f2\u5185\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u51fa\u751f\u5f8c\u306b\u4f53\u91cd\u5897\u52a0\u4e0d\u826f\uff08Failure to thrive\uff09\u3092\u6765\u3059\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u3053\u308c\u306f\u6442\u98df\u969c\u5bb3\uff08\u98f2\u307f\u8fbc\u307f\u306b\u304f\u3055\u3084\u80c3\u98df\u9053\u9006\u6d41\uff09\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u4f4e\u8eab\u9577:<\/strong> \u5e7c\u5150\u671f\u4ee5\u964d\u3001\u4f4e\u8eab\u9577\u306b\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>5. \u5408\u4f75\u75c7\uff08\u81d3\u5668\u969c\u5bb3\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5148\u5929\u6027\u5fc3\u75be\u60a3:<\/strong> \u7d04\u534a\u6570\u306e\u60a3\u8005\u3055\u3093\u306b\u5fc3\u75be\u60a3\uff08\u5fc3\u623f\u4e2d\u9694\u6b20\u640d\u75c7\u3001\u5fc3\u5ba4\u4e2d\u9694\u6b20\u640d\u75c7\u3001\u52d5\u8108\u7ba1\u958b\u5b58\u75c7\u3001\u30d5\u30a1\u30ed\u30fc\u56db\u5fb4\u75c7\u306a\u3069\uff09\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6ccc\u5c3f\u751f\u6b96\u5668\u7cfb:<\/strong> \u7537\u5150\u3067\u306f\u505c\u7559\u7cbe\u5de3\u3001\u5973\u5150\u3067\u306f\u5c0f\u9670\u5507\u306e\u4f4e\u5f62\u6210\u306a\u3069\u304c\u898b\u3089\u308c\u308b\u307b\u304b\u3001\u6c34\u814e\u75c7\u3084\u814e\u5947\u5f62\u304c\u5408\u4f75\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u305d\u306e\u4ed6:<\/strong> \u9f20\u5f84\u30d8\u30eb\u30cb\u30a2\u3001\u3066\u3093\u304b\u3093\u767a\u4f5c\u3001\u659c\u8996\u306a\u3069\u306e\u773c\u79d1\u7684\u7570\u5e38\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u539f\u56e0<\/strong><\/h2>\n\n\n\n<p>16\u756a\u67d3\u8272\u4f53\u77ed\u8155\uff0816p13.3\uff09\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u306e\u91cd\u8907\uff08\u30b3\u30d4\u30fc\u6570\u5897\u52a0\uff09\u304c\u539f\u56e0\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u907a\u4f1d\u5b50\u91cf\u52b9\u679c\uff08Gene Dosage Effect\uff09<\/strong><\/p>\n\n\n\n<p>\u901a\u5e38\u3001\u30d2\u30c8\u306e\u7d30\u80de\u306b\u306f\u907a\u4f1d\u5b50\u304c2\u3064\uff08\u7236\u7531\u6765\u30fb\u6bcd\u7531\u6765\uff09\u305a\u3064\u5b58\u5728\u3057\u3001\u9069\u5207\u306a\u91cf\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308b\u3053\u3068\u3067\u751f\u547d\u6d3b\u52d5\u3092\u7dad\u6301\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u91cd\u8907\u306b\u3088\u3063\u3066\u907a\u4f1d\u5b50\u304c3\u3064\u306b\u306a\u308b\u3068\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u904e\u5270\u306b\u4f5c\u3089\u308c\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>CREBBP\u907a\u4f1d\u5b50\u306f\u3001\u8ee2\u5199\u5171\u5f79\u56e0\u5b50\u3068\u3057\u3066DNA\u306e\u8aad\u307f\u53d6\u308a\u3092\u5e83\u7bc4\u56f2\u306b\u5236\u5fa1\u3059\u308b\u300c\u53f8\u4ee4\u5854\u300d\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u53f8\u4ee4\u5854\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u7d30\u80de\u306e\u5897\u6b96\u3084\u5206\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5f71\u97ff\u304c\u51fa\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9aa8\u683c\u5f62\u6210:<\/strong> \u6307\u3084\u95a2\u7bc0\u306e\u5f62\u6210\u30b7\u30b0\u30ca\u30eb\u304c\u4e71\u308c\u3001\u95a2\u7bc0\u62d8\u7e2e\u3084\u6307\u306e\u5f62\u614b\u7570\u5e38\u304c\u751f\u3058\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8133\u767a\u9054:<\/strong> \u795e\u7d4c\u7d30\u80de\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u5f62\u6210\u304c\u3046\u307e\u304f\u3044\u304b\u305a\u3001\u77e5\u7684\u969c\u5bb3\u3084\u767a\u9054\u9045\u6ede\u304c\u751f\u3058\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u767a\u751f\u6a5f\u5e8f<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>De novo\uff08\u65b0\u751f\u7a81\u7136\u5909\u7570\uff09:<\/strong> \u591a\u304f\u306e\u75c7\u4f8b\u306f\u3001\u4e21\u89aa\u306e\u67d3\u8272\u4f53\u306f\u6b63\u5e38\u3067\u3001\u53d7\u7cbe\u5375\u304c\u3067\u304d\u308b\u904e\u7a0b\u3067\u5076\u7136\u751f\u3058\u305f\u7a81\u7136\u5909\u7570\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u6027\uff08\u89aa\u306e\u8ee2\u5ea7\uff09:<\/strong> \u7a00\u306b\u3001\u89aa\u304c\u300c\u5747\u8861\u578b\u8ee2\u5ea7\u300d\u306e\u4fdd\u56e0\u8005\u3067\u3042\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\n<ul class=\"wp-block-list\">\n<li>\u89aa\u306e\u67d3\u8272\u4f53\u306e\u4e00\u90e8\u304c\u5165\u308c\u66ff\u308f\u3063\u3066\u3044\u308b\u3060\u3051\u3067\u3042\u308c\u3070\u3001\u907a\u4f1d\u5b50\u306e\u300c\u91cf\u300d\u306f\u6b63\u5e38\u306a\u306e\u3067\u89aa\u306f\u7121\u75c7\u72b6\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u3057\u304b\u3057\u3001\u5b50\u4f9b\u306b\u67d3\u8272\u4f53\u304c\u53d7\u3051\u7d99\u304c\u308c\u308b\u969b\u3001\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3066\u300c16p13.3\u90e8\u5206\u306e\u91cd\u8907\u300d\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u5834\u5408\u3001\u6b21\u5b50\u3078\u306e\u518d\u767a\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u305f\u3081\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u304c\u975e\u5e38\u306b\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u904e\u5270\u306a\u67d3\u8272\u4f53\u9818\u57df\u3092\u53d6\u308a\u9664\u304f\u3088\u3046\u306a\u6839\u672c\u7684\u306a\u907a\u4f1d\u5b50\u6cbb\u7642\u6cd5\u306f\u73fe\u6642\u70b9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u6cbb\u7642\u306f\u3001\u73fe\u308c\u3066\u3044\u308b\u75c7\u72b6\u3092\u7de9\u548c\u3057\u3001\u6a5f\u80fd\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u305f\u3081\u306e\u5bfe\u75c7\u7642\u6cd5\u3068\u5305\u62ec\u7684\u306a\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u304c\u4e2d\u5fc3\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u7642\u80b2\u30fb\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\uff08\u6975\u3081\u3066\u91cd\u8981\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7406\u5b66\u7642\u6cd5\uff08PT\uff09:<\/strong> \u95a2\u7bc0\u62d8\u7e2e\u3084\u7b4b\u7dca\u5f35\u4f4e\u4e0b\u304c\u3042\u308b\u5834\u5408\u3001\u95a2\u7bc0\u306e\u53ef\u52d5\u57df\u3092\u7dad\u6301\u30fb\u62e1\u5927\u3059\u308b\u305f\u3081\u306e\u30b9\u30c8\u30ec\u30c3\u30c1\u3084\u3001\u904b\u52d5\u767a\u9054\u3092\u4fc3\u3059\u8a13\u7df4\u3092\u884c\u3044\u307e\u3059\u3002\u88c5\u5177\uff08\u77ed\u4e0b\u80a2\u88c5\u5177\u306a\u3069\uff09\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u4f5c\u696d\u7642\u6cd5\uff08OT\uff09:<\/strong> \u624b\u6307\u306e\u5909\u5f62\u3084\u4f7f\u3044\u306b\u304f\u3055\u306b\u5bfe\u3057\u3001\u904a\u3073\u3092\u901a\u3058\u305f\u5fae\u7d30\u904b\u52d5\u306e\u8a13\u7df4\u3084\u3001\u65e5\u5e38\u751f\u6d3b\u7528\u5177\u306e\u5de5\u592b\uff08\u6301\u3061\u3084\u3059\u3044\u30b9\u30d7\u30fc\u30f3\u306a\u3069\uff09\u3092\u6307\u5c0e\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8a00\u8a9e\u8074\u899a\u7642\u6cd5\uff08ST\uff09:<\/strong> \u8a00\u8449\u306e\u9045\u308c\u306b\u5bfe\u3057\u3001\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u624b\u6bb5\uff08\u30b8\u30a7\u30b9\u30c1\u30e3\u30fc\u3001\u7d75\u30ab\u30fc\u30c9\u3001AAC\u6a5f\u5668\uff09\u3092\u78ba\u4fdd\u3059\u308b\u652f\u63f4\u3092\u884c\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u6442\u98df\u56a5\u4e0b\u969c\u5bb3\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u5b89\u5168\u306a\u98df\u4e8b\u5f62\u614b\u3084\u98df\u3079\u65b9\u306e\u6307\u5c0e\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u6574\u5f62\u5916\u79d1\u7684\u6cbb\u7642<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u7bc0\u62d8\u7e2e\u30fb\u5185\u53cd\u8db3:<\/strong> \u751f\u5f8c\u65e9\u671f\u304b\u3089\u30ae\u30d7\u30b9\u77ef\u6b63\u3084\u88c5\u5177\u7642\u6cd5\u3092\u884c\u3044\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u624b\u8853\uff08\u8171\u5ef6\u9577\u8853\u306a\u3069\uff09\u3092\u691c\u8a0e\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5074\u5f2f\u75c7:<\/strong> \u6210\u9577\u306b\u4f34\u3044\u80cc\u9aa8\u304c\u66f2\u304c\u3063\u3066\u304f\u308b\u5834\u5408\u304c\u3042\u308b\u305f\u3081\u3001\u5b9a\u671f\u7684\u306a\u30c1\u30a7\u30c3\u30af\u3068\u3001\u9032\u884c\u5ea6\u306b\u5fdc\u3058\u305f\u88c5\u5177\u7642\u6cd5\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u5185\u79d1\u7684\u30fb\u5916\u79d1\u7684\u7ba1\u7406<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5fc3\u75be\u60a3:<\/strong> \u8efd\u5ea6\u3067\u3042\u308c\u3070\u7d4c\u904e\u89b3\u5bdf\u3068\u306a\u308a\u307e\u3059\u304c\u3001\u624b\u8853\u304c\u5fc5\u8981\u306a\u5834\u5408\u306f\u5faa\u74b0\u5668\u5916\u79d1\u3067\u5bfe\u5fdc\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6804\u990a\u7ba1\u7406:<\/strong> \u54fa\u4e73\u4e0d\u826f\u3084\u4f53\u91cd\u5897\u52a0\u4e0d\u826f\u304c\u8457\u3057\u3044\u5834\u5408\u3001\u9ad8\u30ab\u30ed\u30ea\u30fc\u30df\u30eb\u30af\u306e\u4f7f\u7528\u3084\u3001\u4e00\u6642\u7684\u306b\u7d4c\u7ba1\u6804\u990a\uff08\u9f3b\u30c1\u30e5\u30fc\u30d6\u3084\u80c3\u308d\u3046\uff09\u3092\u7528\u3044\u3066\u5341\u5206\u306a\u6804\u990a\u3092\u78ba\u4fdd\u3057\u3001\u6210\u9577\u3092\u652f\u3048\u307e\u3059\u3002\u80c3\u98df\u9053\u9006\u6d41\u306b\u5bfe\u3057\u3066\u306f\u85ac\u7269\u7642\u6cd5\u3084\u5916\u79d1\u7684\u6cbb\u7642\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u305d\u306e\u4ed6:<\/strong> \u505c\u7559\u7cbe\u5de3\u3084\u30d8\u30eb\u30cb\u30a2\u306b\u5bfe\u3059\u308b\u624b\u8853\u3001\u3066\u3093\u304b\u3093\u306b\u5bfe\u3059\u308b\u85ac\u7269\u7642\u6cd5\u306a\u3069\u3001\u5408\u4f75\u75c7\u306b\u5fdc\u3058\u305f\u6cbb\u7642\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>4. \u5bb6\u65cf\u652f\u63f4\u3068\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u672c\u75be\u60a3\u306f\u5e0c\u5c11\u3067\u3042\u308a\u3001\u60c5\u5831\u304c\u5c11\u306a\u3044\u4e2d\u3067\u80b2\u5150\u3092\u3059\u308b\u5bb6\u65cf\u3078\u306e\u5fc3\u7406\u7684\u30fb\u793e\u4f1a\u7684\u30b5\u30dd\u30fc\u30c8\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u6b21\u5b50\u306e\u598a\u5a20\u3092\u8003\u3048\u3066\u3044\u308b\u5834\u5408\u306a\u3069\u3001\u89aa\u306e\u67d3\u8272\u4f53\u691c\u67fb\u3092\u884c\u3046\u304b\u3069\u3046\u304b\u3092\u542b\u3081\u3001\u5c02\u9580\u5bb6\uff08\u81e8\u5e8a\u907a\u4f1d\u5c02\u9580\u533b\u3084\u8a8d\u5b9a\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\uff09\u3068\u76f8\u8ac7\u3059\u308b\u6a5f\u4f1a\u3092\u6301\u3064\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>16p13.3 duplication syndrome\u306f\u300116\u756a\u67d3\u8272\u4f53\u672b\u7aef\u306e\u907a\u4f1d\u5b50\uff08\u4e3b\u306bCREBBP\uff09\u304c\u5897\u3048\u308b\u3053\u3068\u3067\u751f\u3058\u308b\u5148\u5929\u6027\u306e\u4f53\u8cea\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u300cRubinstein-Taybi\u75c7\u5019\u7fa4\uff08\u6b20\u5931\uff09\u300d\u306e\u9006\u306e\u72b6\u614b\u3067\u3059\u304c\u3001\u75c7\u72b6\u306f\u7570\u306a\u308a\u3001\u7d30\u9577\u3044\u6307\u3084\u95a2\u7bc0\u306e\u52d5\u304b\u3057\u306b\u304f\u3055\u3001\u3086\u3063\u304f\u308a\u3068\u3057\u305f\u767a\u9054\u306a\u3069\u304c\u7279\u5fb4\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u65e9\u671f\u304b\u3089\u5fc3\u81d3\u3084\u95a2\u7bc0\u306a\u3069\u306e\u30b1\u30a2\u3092\u884c\u3044\u3001\u7406\u5b66\u7642\u6cd5\u3084\u4f5c\u696d\u7642\u6cd5\u306a\u3069\u306e\u7642\u80b2\u3092\u7d99\u7d9a\u3059\u308b\u3053\u3068\u3067\u3001\u304a\u5b50\u3055\u3093\u306e\u6301\u3063\u3066\u3044\u308b\u529b\u3092\u4f38\u3070\u3057\u3001\u751f\u6d3b\u306e\u8cea\u3092\u9ad8\u3081\u3066\u3044\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u5e0c\u5c11\u306a\u75be\u60a3\u3060\u304b\u3089\u3053\u305d\u3001\u533b\u7642\u30c1\u30fc\u30e0\u3068\u9023\u643a\u3057\u3001\u9577\u671f\u7684\u306a\u8996\u70b9\u3067\u306e\u30b5\u30dd\u30fc\u30c8\u4f53\u5236\u3092\u4f5c\u3063\u3066\u3044\u304f\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Thienpont B, et al.<\/strong> (2010). The recurrent 16p13.3 microduplication syndrome: delineation of the clinical phenotype and involvement of the <em>CREBBP<\/em> gene. <em>American Journal of Human Genetics<\/em>, 86(4), 523-531.\n<ul class=\"wp-block-list\">\n<li>(\u203b\u672c\u75be\u60a3\u306e\u81e8\u5e8a\u50cf\u3068\u539f\u56e0\u907a\u4f1d\u5b50CREBBP\u3068\u306e\u95a2\u9023\u3092\u660e\u78ba\u306b\u5b9a\u7fa9\u3065\u3051\u305f\u3001\u6700\u3082\u91cd\u8981\u304b\u3064\u57fa\u672c\u7684\u306a\u8ad6\u6587\u3067\u3059)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Unique (Rare Chromosome Disorder Support Group)<\/strong>: <em>16p13.3 microduplications<\/em> (2018).\n<ul class=\"wp-block-list\">\n<li>(\u60a3\u8005\u5bb6\u65cf\u5411\u3051\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3002\u751f\u6d3b\u9762\u3067\u306e\u30a2\u30c9\u30d0\u30a4\u30b9\u3084\u8a73\u7d30\u306a\u75c7\u72b6\u304c\u7db2\u7f85\u3055\u308c\u3066\u3044\u307e\u3059)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Ciaccio, et al.<\/strong> (2017). Duplication 16p13.3 and the CREBBP gene: Confirmation of the phenotype. <em>European Journal of Medical Genetics<\/em>.<\/li>\n\n\n\n<li><strong>ClinGen Dosage Sensitivity Curation<\/strong>: <em>CREBBP<\/em> (Triplosensitivity score: 3 &#8211; Sufficient evidence).\n<ul class=\"wp-block-list\">\n<li>(CREBBP\u907a\u4f1d\u5b50\u304c\u91cd\u8907\uff083\u30b3\u30d4\u30fc\uff09\u306b\u306a\u308b\u3053\u3068\u3067\u75c5\u539f\u6027\u3092\u6301\u3064\u3053\u3068\u3092\u88cf\u4ed8\u3051\u308b\u5c02\u9580\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u8a55\u4fa1)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Mattina T, et al.<\/strong> (2012). The 16p13.3 duplication syndrome. <em>Orphanet Encyclopedia<\/em>.<\/li>\n\n\n\n<li><strong>DECIPHER Database<\/strong>: <em>Genomic coordinates and phenotype data for 16p13.3 duplications.<\/em><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<style>\n.entry-content li {\n  text-indent: -1rem !important;\n}\n<\/style>\n<p>\u8a73\u3057\u304f\u306f <a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/clinic\/\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u5168\u56fd\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e00\u89a7<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-16707","genetic-screening","type-genetic-screening","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/16707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/genetic-screening"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/16707\/revisions"}],"predecessor-version":[{"id":16709,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/16707\/revisions\/16709"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=16707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}