{"id":16725,"date":"2026-01-20T00:58:52","date_gmt":"2026-01-20T00:58:52","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?post_type=genetic-screening&#038;p=16725"},"modified":"2026-01-20T05:50:36","modified_gmt":"2026-01-20T05:50:36","slug":"17p13-3-duplication-syndrome","status":"publish","type":"genetic-screening","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/genetic-screening\/17p13-3-duplication-syndrome\/","title":{"rendered":"17p13.3 duplication syndrome"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u5225\u540d\u30fb\u95a2\u9023\u75be\u60a3\u540d<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>17p13.3\u91cd\u8907\u75c7\u5019\u7fa4<\/li>\n\n\n\n<li>17p13.3\u5fae\u7d30\u91cd\u8907\u75c7\u5019\u7fa4\uff0816p13.3 microduplication syndrome\uff09<\/li>\n\n\n\n<li>\u90e8\u5206\u7684\u30c8\u30ea\u30bd\u30df\u30fc17p13.3\uff08Partial trisomy 17p13.3\uff09<\/li>\n\n\n\n<li>17p13.3\u30b3\u30d4\u30fc\u6570\u5909\u7570\uff08\u91cd\u8907\uff09\uff0817p13.3 copy number variant, duplication\uff09<\/li>\n\n\n\n<li>\u95a2\u9023\uff1aYWHAE\u91cd\u8907\u75c7\u5019\u7fa4\uff08YWHAE duplication syndrome\uff09<\/li>\n\n\n\n<li>\u95a2\u9023\uff1aLIS1 (PAFAH1B1) \u91cd\u8907\u75c7\u5019\u7fa4\uff08LIS1 duplication syndrome\uff09<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5bfe\u8c61\u67d3\u8272\u4f53\u9818\u57df<\/strong><\/h2>\n\n\n\n<p><strong>17\u756a\u67d3\u8272\u4f53 \u77ed\u8155\uff08p\uff0913.3\u9818\u57df<\/strong><\/p>\n\n\n\n<p>\u672c\u75be\u60a3\u306f\u3001\u30d2\u30c8\u306e17\u756a\u67d3\u8272\u4f53\u306e\u77ed\u8155\uff08p\u30a2\u30fc\u30e0\uff09\u306e\u6700\u3082\u672b\u7aef\uff08\u30c6\u30ed\u30e1\u30a2\u5074\uff09\u306b\u4f4d\u7f6e\u3059\u308b\u300c13.3\u300d\u3068\u547c\u3070\u308c\u308b\u30d0\u30f3\u30c9\u9818\u57df\u306b\u304a\u3044\u3066\u3001DNA\u914d\u5217\u306e\u4e00\u90e8\u304c\u91cd\u8907\uff08\u30b3\u30d4\u30fc\u6570\u304c\u901a\u5e38\u306e2\u672c\u304b\u30893\u672c\u306b\u5897\u52a0\uff09\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u751f\u3058\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3010\u9818\u57df\u306e\u907a\u4f1d\u5b66\u7684\u8a73\u7d30\u3068\u91cd\u8981\u6027\u3011<\/p>\n\n\n\n<p>17p13.3\u9818\u57df\u306f\u3001\u907a\u4f1d\u5b50\u5bc6\u5ea6\u304c\u9ad8\u304f\u3001\u8133\u306e\u767a\u9054\u306b\u4e0d\u53ef\u6b20\u306a\u907a\u4f1d\u5b50\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u9818\u57df\u306e\u300c\u6b20\u5931\uff08deletion\uff09\u300d\u306f\u3001\u8133\u306e\u30b7\u30ef\u304c\u4f5c\u3089\u308c\u306a\u3044\u300c\u6ed1\u8133\u75c7\uff08Lissencephaly\uff09\u300d\u3092\u7279\u5fb4\u3068\u3059\u308b\u30df\u30e9\u30fc\u30fb\u30c7\u30a3\u30fc\u30ab\u30fc\u75c7\u5019\u7fa4\uff08Miller-Dieker syndrome\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3067\u6709\u540d\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u75be\u60a3\uff08\u91cd\u8907\u75c7\u5019\u7fa4\uff09\u306f\u3001\u305d\u306e\u300c\u9006\uff08reciprocal\uff09\u300d\u306e\u72b6\u614b\u3067\u3042\u308a\u3001\u6b20\u5931\u75c7\u5019\u7fa4\u3068\u306f\u7570\u306a\u308b\u3001\u3057\u304b\u3057\u591a\u69d8\u306a\u795e\u7d4c\u767a\u9054\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30102\u3064\u306e\u91cd\u8981\u306a\u8cac\u4efb\u907a\u4f1d\u5b50\u3011<\/p>\n\n\n\n<p>17p13.3\u91cd\u8907\u75c7\u5019\u7fa4\u306e\u75c7\u72b6\u306f\u3001\u91cd\u8907\u7bc4\u56f2\u306b\u4ee5\u4e0b\u306e\u3069\u3061\u3089\uff08\u3042\u308b\u3044\u306f\u4e21\u65b9\uff09\u306e\u907a\u4f1d\u5b50\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u304b\u306b\u3088\u3063\u3066\u3001\u30af\u30e9\u30b91\u3068\u30af\u30e9\u30b92\u3068\u3044\u3046\u5168\u304f\u7570\u306a\u308b\u30bf\u30a4\u30d7\u306b\u5206\u985e\u3055\u308c\u308b\u3053\u3068\u304c\u6700\u5927\u306e\u7279\u5fb4\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>YWHAE (Tyrosine 3-Monooxygenase\/Tryptophan 5-Monooxygenase Activation Protein Epsilon):<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u795e\u7d4c\u7d30\u80de\u306e\u79fb\u52d5\u3084\u914d\u7f6e\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u91cd\u8907\uff08\u904e\u5270\uff09\u306f\u3001\u300c\u904e\u6210\u9577\uff08\u4f53\u304c\u5927\u304d\u3044\uff09\u300d<strong>\u3084<\/strong>\u300c\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7\uff08ASD\uff09\u300d\u306e\u4e3b\u306a\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>PAFAH1B1 (LIS1):<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8133\u306e\u5f62\u6210\u306b\u6700\u3082\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3059\u3002\u6b20\u5931\u3059\u308b\u3068\u6ed1\u8133\u75c7\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u9006\u306b\u91cd\u8907\uff08\u904e\u5270\uff09\u3059\u308b\u3068\u3001<strong>\u300c\u5c0f\u982d\u75c7\uff08\u982d\u304c\u5c0f\u3055\u3044\uff09\u300d\u3084\u300c\u6210\u9577\u969c\u5bb3\uff08\u4f53\u304c\u5c0f\u3055\u3044\uff09\u300d<\/strong>\u3001\u8133\u306e\u5fae\u7d30\u306a\u69cb\u9020\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3064\u307e\u308a\u3001\u540c\u3058\u300c17p13.3\u91cd\u8907\u300d\u3068\u3044\u3046\u8a3a\u65ad\u540d\u3067\u3042\u3063\u3066\u3082\u3001<em>YWHAE<\/em>\u304c\u5897\u3048\u3066\u3044\u308b\u306e\u304b\u3001<em>PAFAH1B1<\/em>\u304c\u5897\u3048\u3066\u3044\u308b\u306e\u304b\u306b\u3088\u3063\u3066\u3001\u75c7\u72b6\uff08\u7279\u306b\u4f53\u683c\u3084\u982d\u306e\u5927\u304d\u3055\uff09\u304c\u6b63\u53cd\u5bfe\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u767a\u751f\u983b\u5ea6<\/strong><\/h2>\n\n\n\n<p><strong>\u7a00\uff08Rare\uff09<\/strong><\/p>\n\n\n\n<p>\u6b63\u78ba\u306a\u767a\u751f\u983b\u5ea6\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u30df\u30e9\u30fc\u30fb\u30c7\u30a3\u30fc\u30ab\u30fc\u75c7\u5019\u7fa4\uff08\u6b20\u5931\uff09\u306b\u6bd4\u3079\u308b\u3068\u5831\u544a\u6570\u306f\u5c11\u306a\u3044\u50be\u5411\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u3053\u308c\u306f\u91cd\u8907\u75c7\u5019\u7fa4\u306e\u75c7\u72b6\u304c\u6b20\u5931\u75c7\u5019\u7fa4\u307b\u3069\u5287\u7684\uff08\u91cd\u5ea6\u306e\u8133\u5947\u5f62\u306a\u3069\uff09\u3067\u306f\u306a\u3044\u5834\u5408\u304c\u591a\u304f\u3001\u8a3a\u65ad\u306b\u81f3\u3063\u3066\u3044\u306a\u3044\uff08\u904e\u5c11\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b\uff09\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u67d3\u8272\u4f53\u691c\u67fb\uff08CMA\uff09\u306e\u666e\u53ca\u306b\u3088\u308a\u3001\u539f\u56e0\u4e0d\u660e\u306e\u767a\u9054\u9045\u6ede\u3084\u81ea\u9589\u75c7\u3092\u6301\u3064\u60a3\u8005\u3055\u3093\u306e\u4e2d\u304b\u3089\u767a\u898b\u3055\u308c\u308b\u30b1\u30fc\u30b9\u304c\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u63a8\u8a08\u3067\u306f\u6570\u4e07\u4eba\u306b1\u4eba\u7a0b\u5ea6\u306e\u983b\u5ea6\u3067\u306f\u306a\u3044\u304b\u3068\u3082\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u81e8\u5e8a\u7684\u7279\u5fb4\uff08\u75c7\u72b6\uff09<\/strong><\/h2>\n\n\n\n<p>\u524d\u8ff0\u306e\u901a\u308a\u3001\u91cd\u8907\u3059\u308b\u907a\u4f1d\u5b50\u306e\u7bc4\u56f2\u306b\u3088\u3063\u3066\u75c7\u72b6\u304c\u7570\u306a\u308a\u307e\u3059\u304c\u3001\u3053\u3053\u3067\u306f\u6700\u3082\u4e00\u822c\u7684\u306a\u300c\u8907\u5408\u7684\u306a\u75c7\u72b6\u300d\u304a\u3088\u3073\u300c\u5404\u30bf\u30a4\u30d7\u306e\u9055\u3044\u300d\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u5171\u901a\u3059\u308b\u795e\u7d4c\u767a\u9054\u30fb\u7cbe\u795e\u75c7\u72b6<\/strong><\/p>\n\n\n\n<p>\u3069\u306e\u30bf\u30a4\u30d7\u306e\u91cd\u8907\u3067\u3042\u3063\u3066\u3082\u3001\u795e\u7d4c\u767a\u9054\u3078\u306e\u5f71\u97ff\u306f\u307b\u307c\u5fc5\u767a\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u767a\u9054\u9045\u6ede\uff08DD\uff09:<\/strong> \u9996\u3059\u308f\u308a\u3001\u304a\u5ea7\u308a\u3001\u6b69\u884c\u306a\u3069\u306e\u904b\u52d5\u767a\u9054\u3001\u304a\u3088\u3073\u8a00\u8449\u306e\u7372\u5f97\u306b\u9045\u308c\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u9045\u308c\u306e\u7a0b\u5ea6\u306f\u8efd\u5ea6\u304b\u3089\u91cd\u5ea6\u307e\u3067\u5e45\u5e83\u3044\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u77e5\u7684\u969c\u5bb3\uff08ID\uff09:<\/strong> \u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u3067\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u306e\u77e5\u7684\u969c\u5bb3\u3092\u4f34\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u884c\u52d5\u7279\u6027\uff08\u7279\u306bYWHAE\u91cd\u8907\u306b\u95a2\u4e0e\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u81ea\u9589\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u75c7\uff08ASD\uff09:<\/strong> \u793e\u4f1a\u7684\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u56f0\u96e3\u3001\u8996\u7dda\u3092\u5408\u308f\u305b\u306a\u3044\u3001\u53cd\u5fa9\u884c\u52d5\u306a\u3069\u306e\u7279\u5fb4\u304c\u9ad8\u983b\u5ea6\u3067\u898b\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6ce8\u610f\u6b20\u9665\u30fb\u591a\u52d5\u6027\u969c\u5bb3\uff08ADHD\uff09:<\/strong> \u591a\u52d5\u3001\u885d\u52d5\u6027\u3001\u6ce8\u610f\u6563\u6f2b\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u305d\u306e\u4ed6\u3001\u4e0d\u5b89\u969c\u5bb3\u3084\u653b\u6483\u7684\u884c\u52d5\u304c\u898b\u3089\u308c\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u8eab\u4f53\u7684\u7279\u5fb4\u30fb\u6210\u9577\uff08\u30bf\u30a4\u30d7\u306b\u3088\u308b\u9055\u3044\uff09<\/strong><\/p>\n\n\n\n<p>\u3053\u3053\u304c\u8a3a\u65ad\u4e0a\u306e\u91cd\u8981\u306a\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30af\u30e9\u30b91\uff08YWHAE\u306e\u307f\u91cd\u8907\u3001PAFAH1B1\u306f\u6b63\u5e38\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u904e\u6210\u9577\uff08Macrosomia\uff09:<\/strong> \u8eab\u9577\u3084\u4f53\u91cd\u304c\u5e73\u5747\u3088\u308a\u3082\u5927\u304d\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u76f8\u5bfe\u7684\u306a\u5927\u982d\u75c7:<\/strong> \u4f53\u683c\u306b\u5408\u308f\u305b\u3066\u982d\u56f2\u3082\u5927\u304d\u3081\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u9854\u8c8c:<\/strong> \u524d\u982d\u90e8\uff08\u304a\u3067\u3053\uff09\u304c\u5e83\u3044\u3001\u9f3b\u6839\u90e8\u304c\u4f4e\u3044\u3001\u773c\u9593\u958b\u96e2\uff08\u76ee\u304c\u96e2\u308c\u3066\u3044\u308b\uff09\u306a\u3069\u306e\u7279\u5fb4\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30af\u30e9\u30b92\uff08PAFAH1B1\u3092\u542b\u3080\u91cd\u8907\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u6210\u9577\u969c\u5bb3:<\/strong> \u8eab\u9577\u30fb\u4f53\u91cd\u306e\u4f38\u3073\u304c\u60aa\u304f\u3001\u5c0f\u67c4\u306a\u4f53\u683c\u306b\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5c0f\u982d\u75c7\uff08Microcephaly\uff09:<\/strong> \u982d\u56f2\u304c\u5e73\u5747\u3088\u308a\u3082\u5c0f\u3055\u304f\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8133\u6881\u306e\u4f4e\u5f62\u6210:<\/strong> \u8133\u306e\u5de6\u53f3\u3092\u3064\u306a\u3050\u300c\u8133\u6881\u300d\u304c\u8584\u3044\u306a\u3069\u306e\u5fae\u7d30\u306a\u8133\u5f62\u6210\u7570\u5e38\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u9854\u8c8c:<\/strong> \u5c0f\u3055\u306a\u984e\u3001\u8033\u306e\u4f4d\u7f6e\u304c\u4f4e\u3044\u306a\u3069\u306e\u7279\u5fb4\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30af\u30e9\u30b93\uff08\u4e21\u65b9\u306e\u907a\u4f1d\u5b50\u3092\u542b\u3080\u5927\u304d\u306a\u91cd\u8907\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u75c7\u72b6\u306f\u30df\u30c3\u30af\u30b9\u3055\u308c\u307e\u3059\u304c\u3001\u3069\u3061\u3089\u304b\u3068\u3044\u3046\u3068<em>YWHAE<\/em>\u306e\u5f71\u97ff\uff08\u904e\u6210\u9577\u3084ASD\u50be\u5411\uff09\u3088\u308a\u3082\u3001<em>PAFAH1B1<\/em>\u306e\u5f71\u97ff\uff08\u5c0f\u982d\u75c7\u3084\u767a\u9054\u306e\u9045\u308c\u306e\u91cd\u3055\uff09\u304c\u5f37\u304f\u51fa\u308b\u5834\u5408\u3084\u3001\u4e2d\u9593\u7684\u306a\u8868\u73fe\u578b\u306b\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u305d\u306e\u4ed6\u306e\u5408\u4f75\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7b4b\u7dca\u5f35\u4f4e\u4e0b\uff08Hypotonia\uff09:<\/strong> \u4e73\u5e7c\u5150\u671f\u306b\u4f53\u304c\u67d4\u3089\u304b\u304f\u3001\u904b\u52d5\u767a\u9054\u306e\u9045\u308c\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u3066\u3093\u304b\u3093:<\/strong> \u6b20\u5931\u75c7\u5019\u7fa4\u307b\u3069\u9ad8\u983b\u5ea6\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u4e00\u90e8\u306e\u60a3\u8005\u3055\u3093\u3067\u767a\u4f5c\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u624b\u8db3\u306e\u7570\u5e38:<\/strong> \u624b\u6307\u306e\u77ed\u7e2e\u3084\u3001\u7b2c5\u6307\u306e\u6e7e\u66f2\u306a\u3069\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5185\u81d3\u5947\u5f62:<\/strong> \u5148\u5929\u6027\u5fc3\u75be\u60a3\u3084\u814e\u81d3\u306e\u7570\u5e38\u306a\u3069\u304c\u7a00\u306b\u5408\u4f75\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5fc5\u9808\u306e\u75c7\u72b6\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u539f\u56e0<\/strong><\/h2>\n\n\n\n<p>17\u756a\u67d3\u8272\u4f53\u77ed\u8155\uff0817p13.3\uff09\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u306e\u91cd\u8907\uff08\u30c8\u30ea\u30d7\u30ed\u30bb\u30f3\u30b7\u30c6\u30a3\uff09\u304c\u539f\u56e0\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u907a\u4f1d\u5b50\u91cf\u52b9\u679c\uff08Gene Dosage Effect\uff09<\/strong><\/p>\n\n\n\n<p>\u300c\u907a\u4f1d\u5b50\u306f\u591a\u3051\u308c\u3070\u826f\u3044\u300d\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>YWHAE\u907a\u4f1d\u5b50:<br>\u3053\u306e\u907a\u4f1d\u5b50\u304c\u4f5c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\uff0814-3-3\u03b5\uff09\u306f\u3001\u795e\u7d4c\u7d30\u80de\u304c\u8133\u5185\u306e\u6b63\u3057\u3044\u4f4d\u7f6e\u306b\u79fb\u52d5\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3067\u3059\u3002\u3053\u308c\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u795e\u7d4c\u7d30\u80de\u306e\u79fb\u52d5\u304c\u4e0d\u9069\u5207\u306b\u306a\u308a\u3001\u795e\u7d4c\u56de\u8def\u306e\u5f62\u6210\u4e0d\u5168\uff08\u30b7\u30ca\u30d7\u30b9\u5f62\u6210\u7570\u5e38\uff09\u3092\u62db\u304d\u3001\u81ea\u9589\u75c7\u306a\u3069\u306e\u539f\u56e0\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>PAFAH1B1 (LIS1) \u907a\u4f1d\u5b50:<br>LIS1\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7d30\u80de\u9aa8\u683c\uff08\u5fae\u5c0f\u7ba1\uff09\u306e\u5236\u5fa1\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002\u91cf\u304c\u534a\u5206\u3060\u3068\u300c\u6ed1\u8133\u75c7\u300d\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u91cf\u304c1.5\u500d\uff083\u30b3\u30d4\u30fc\uff09\u306b\u306a\u308b\u3068\u3001\u7d30\u80de\u306e\u79fb\u52d5\u901f\u5ea6\u3084\u5206\u88c2\u306b\u5fae\u5999\u306a\u30d6\u30ec\u30fc\u30ad\u304c\u304b\u304b\u308a\u3001\u8133\u304c\u5c0f\u3055\u304f\u306a\u3063\u305f\u308a\uff08\u5c0f\u982d\u75c7\uff09\u3001\u69cb\u9020\u304c\u4e71\u308c\u305f\u308a\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u767a\u751f\u6a5f\u5e8f<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>De novo\uff08\u65b0\u751f\u7a81\u7136\u5909\u7570\uff09:<\/strong> \u591a\u304f\u306e\u75c7\u4f8b\u306f\u3001\u4e21\u89aa\u304b\u3089\u306e\u907a\u4f1d\u3067\u306f\u306a\u304f\u3001\u53d7\u7cbe\u306e\u904e\u7a0b\u3067\u5076\u7136\u751f\u3058\u305f\u7a81\u7136\u5909\u7570\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u6027\uff08\u89aa\u306e\u8ee2\u5ea7\u306a\u3069\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7a00\u306b\u3001\u89aa\u304c\u300c\u5747\u8861\u578b\u8ee2\u5ea7\u300d\u306e\u4fdd\u56e0\u8005\u3067\u3042\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u307e\u305f\u3001\u89aa\u81ea\u8eab\u304c\u8efd\u5fae\u306a\u75c7\u72b6\uff08\u3042\u308b\u3044\u306f\u7121\u75c7\u72b6\uff09\u306e\u91cd\u8907\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u305d\u308c\u304c\u5b50\u4f9b\u306b\u907a\u4f1d\u3057\u3066\u75c7\u72b6\u304c\u9855\u5728\u5316\u3059\u308b\u30b1\u30fc\u30b9\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b<em>YWHAE<\/em>\u5358\u72ec\u91cd\u8907\u306e\u5834\u5408\u3001\u89aa\u306e\u75c7\u72b6\u304c\u8efd\u304f\u3066\u6c17\u3065\u304b\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8a3a\u65ad\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u4e00\u822c\u7684\u306a\u67d3\u8272\u4f53\u691c\u67fb\uff08G\u30d0\u30f3\u30c9\u6cd5\uff09\u3067\u306f\u3001\u91cd\u8907\u304c\u5c0f\u3055\u3059\u304e\u3066\u691c\u51fa\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u67d3\u8272\u4f53\u691c\u67fb\uff08CMA\uff09:<br>\u5fae\u7d30\u306a\u30b3\u30d4\u30fc\u6570\u5909\u5316\uff08CNV\uff09\u3092\u691c\u51fa\u3059\u308b\u6700\u3082\u78ba\u5b9f\u306a\u65b9\u6cd5\u3067\u3059\u3002\u91cd\u8907\u306e\u7bc4\u56f2\uff08\u30b5\u30a4\u30ba\uff09\u3068\u3001\u305d\u3053\u306b\u542b\u307e\u308c\u308b\u907a\u4f1d\u5b50\uff08YWHAE\u3068PAFAH1B1\u306e\u3069\u3061\u3089\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u304b\uff09\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u75c5\u578b\u306e\u5206\u985e\u3084\u4e88\u5f8c\u306e\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u8133MRI\u691c\u67fb:<br>\u7279\u306bPAFAH1B1\u304c\u542b\u307e\u308c\u308b\u91cd\u8907\u306e\u5834\u5408\u3001\u8133\u6881\u306e\u83f2\u8584\u5316\u3084\u3001\u5c0f\u8133\u306e\u7570\u5e38\u3001\u76ae\u8cea\u306e\u5fae\u7d30\u306a\u5f62\u6210\u7570\u5e38\u304c\u306a\u3044\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u904e\u5270\u306a\u907a\u4f1d\u5b50\u3092\u53d6\u308a\u9664\u304f\u3088\u3046\u306a\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u306f\u73fe\u6642\u70b9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u6cbb\u7642\u306f\u3001\u304a\u5b50\u3055\u3093\u306e\u6301\u3063\u3066\u3044\u308b\u300c\u80b2\u3066\u306b\u304f\u3055\u300d\u3084\u300c\u767a\u9054\u306e\u9045\u308c\u300d\u306b\u5bfe\u3059\u308b\u7642\u80b2\u7684\u652f\u63f4\u3068\u5bfe\u75c7\u7642\u6cd5\u304c\u4e2d\u5fc3\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u767a\u9054\u30fb\u6559\u80b2\u7684\u652f\u63f4\uff08\u65e9\u671f\u7642\u80b2\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7406\u5b66\u7642\u6cd5\uff08PT\uff09:<br>\u7b4b\u7dca\u5f35\u4f4e\u4e0b\u304c\u3042\u308b\u5834\u5408\u3001\u4f53\u5e79\u3092\u935b\u3048\u3001\u5ea7\u308b\u30fb\u6b69\u304f\u3068\u3044\u3063\u305f\u7c97\u5927\u904b\u52d5\u306e\u767a\u9054\u3092\u4fc3\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u4f5c\u696d\u7642\u6cd5\uff08OT\uff09:<br>\u624b\u5148\u306e\u4e0d\u5668\u7528\u3055\u304c\u3042\u308b\u5834\u5408\u3001\u904a\u3073\u3092\u901a\u3058\u3066\u5fae\u7d30\u904b\u52d5\u3092\u8a13\u7df4\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u611f\u899a\u904e\u654f\uff08\u7279\u5b9a\u306e\u97f3\u3084\u611f\u89e6\u3092\u5acc\u304c\u308b\uff09\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u611f\u899a\u7d71\u5408\u7642\u6cd5\u3092\u884c\u3044\u3001\u751f\u6d3b\u3057\u3084\u3059\u304f\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u8a00\u8a9e\u8074\u899a\u7642\u6cd5\uff08ST\uff09:<br>\u8a00\u8449\u306e\u9045\u308c\u306b\u5bfe\u3057\u3001\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u6307\u5c0e\u3092\u884c\u3044\u307e\u3059\u3002\u8996\u899a\u7684\u306a\u624b\u304c\u304b\u308a\uff08\u7d75\u30ab\u30fc\u30c9\u306a\u3069\uff09\u3092\u4f7f\u3046\u3053\u3068\u304c\u6709\u52b9\u306a\u5834\u5408\u304c\u591a\u3044\u3067\u3059\u3002<\/li>\n\n\n\n<li>SST\uff08\u30bd\u30fc\u30b7\u30e3\u30eb\u30b9\u30ad\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09:<br>ASD\u7279\u6027\u304c\u3042\u308b\u5834\u5408\u3001\u96c6\u56e3\u751f\u6d3b\u3067\u306e\u30eb\u30fc\u30eb\u3084\u5bfe\u4eba\u95a2\u4fc2\u306e\u30b9\u30ad\u30eb\u3092\u5b66\u3076\u652f\u63f4\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u884c\u52d5\u30fb\u5fc3\u7406\u9762\u306e\u30b5\u30dd\u30fc\u30c8<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u74b0\u5883\u8abf\u6574:<br>\u3053\u3060\u308f\u308a\u304c\u5f37\u304b\u3063\u305f\u308a\u3001\u5909\u5316\u306b\u5f31\u304b\u3063\u305f\u308a\u3059\u308b\u5834\u5408\u3001\u898b\u901a\u3057\u306e\u6301\u3061\u3084\u3059\u3044\u74b0\u5883\u3092\u4f5c\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u85ac\u7269\u7642\u6cd5:<br>\u591a\u52d5\u3084\u885d\u52d5\u6027\u3001\u7761\u7720\u969c\u5bb3\u3001\u30d1\u30cb\u30c3\u30af\u306a\u3069\u304c\u5f37\u304f\u3001\u65e5\u5e38\u751f\u6d3b\u3084\u5b66\u7fd2\u306b\u652f\u969c\u304c\u51fa\u308b\u5834\u5408\u306f\u3001\u533b\u5e2b\u3068\u76f8\u8ac7\u306e\u4e0a\u3067\u9069\u5207\u306a\u85ac\u7269\u7642\u6cd5\u3092\u691c\u8a0e\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u5408\u4f75\u75c7\u306e\u7ba1\u7406<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u3066\u3093\u304b\u3093:<\/strong> \u767a\u4f5c\u304c\u3042\u308b\u5834\u5408\u306f\u6297\u3066\u3093\u304b\u3093\u85ac\u3067\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5b9a\u671f\u691c\u8a3a:<\/strong> \u6210\u9577\u969c\u5bb3\uff08\u307e\u305f\u306f\u904e\u6210\u9577\uff09\u3084\u5c0f\u982d\u75c7\u306e\u9032\u884c\u304c\u306a\u3044\u304b\u3001\u8eab\u4f53\u8a08\u6e2c\u3092\u5b9a\u671f\u7684\u306b\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>4. \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u91cd\u8907\u306e\u30bf\u30a4\u30d7\uff08\u30af\u30e9\u30b91\u304b2\u304b\uff09\u306b\u3088\u3063\u3066\u3001\u5c06\u6765\u306e\u898b\u901a\u3057\u3084\u304d\u3087\u3046\u3060\u3044\u3078\u306e\u5f71\u97ff\u304c\u7570\u306a\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u6b21\u5b50\u306e\u598a\u5a20\u3092\u8003\u3048\u3066\u3044\u308b\u5834\u5408\u3001\u89aa\u306e\u67d3\u8272\u4f53\u691c\u67fb\u3092\u884c\u3046\u304b\u3069\u3046\u304b\u3092\u542b\u3081\u3001\u5c02\u9580\u5bb6\uff08\u81e8\u5e8a\u907a\u4f1d\u5c02\u9580\u533b\u3084\u8a8d\u5b9a\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\uff09\u3068\u76f8\u8ac7\u3059\u308b\u5834\u3092\u6301\u3064\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>17p13.3 duplication syndrome\u306f\u300117\u756a\u67d3\u8272\u4f53\u306e\u672b\u7aef\u304c\u5897\u3048\u308b\u3053\u3068\u3067\u751f\u3058\u308b\u75be\u60a3\u3067\u3059\u304c\u3001\u305d\u306e\u75c7\u72b6\u306f\u300c\u3069\u306e\u907a\u4f1d\u5b50\u304c\u5897\u3048\u3066\u3044\u308b\u304b\u300d\u306b\u3088\u3063\u3066\u3001\u4f53\u304c\u5927\u304d\u304f\u306a\u3063\u305f\u308a\u5c0f\u3055\u304f\u306a\u3063\u305f\u308a\u3068\u69d8\u3005\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5171\u901a\u3057\u3066\u3044\u308b\u306e\u306f\u3001\u767a\u9054\u306e\u30da\u30fc\u30b9\u304c\u3086\u3063\u304f\u308a\u3067\u3042\u308b\u3053\u3068\u3084\u3001\u81ea\u9589\u75c7\u306a\u3069\u306e\u7279\u6027\u3092\u6301\u3061\u3084\u3059\u3044\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u75be\u60a3\u3092\u6301\u3064\u304a\u5b50\u3055\u3093\u306f\u3001\u8a00\u8449\u3067\u4f1d\u3048\u308b\u306e\u304c\u82e6\u624b\u3067\u3082\u3001\u72ec\u81ea\u306e\u611f\u6027\u3084\u8c4a\u304b\u306a\u611f\u60c5\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u300c\u306a\u305c\u3053\u3046\u306a\u308b\u306e\uff1f\u300d\u3068\u3044\u3046\u539f\u56e0\u304c\u67d3\u8272\u4f53\u306b\u3042\u308b\u3068\u5206\u304b\u308c\u3070\u3001\u305d\u306e\u5b50\u306e\u884c\u52d5\uff08\u3053\u3060\u308f\u308a\u3084\u591a\u52d5\u306a\u3069\uff09\u3092\u300c\u308f\u304c\u307e\u307e\u300d\u3067\u306f\u306a\u304f\u300c\u7279\u6027\u300d\u3068\u3057\u3066\u6349\u3048\u76f4\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u65e9\u671f\u304b\u3089\u305d\u306e\u5b50\u306e\u7279\u6027\u306b\u5408\u308f\u305b\u305f\u7642\u80b2\uff08PT\/OT\/ST\uff09\u3084\u74b0\u5883\u8abf\u6574\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u6301\u3063\u3066\u3044\u308b\u80fd\u529b\u3092\u4f38\u3070\u3057\u3001\u793e\u4f1a\u751f\u6d3b\u3078\u306e\u9069\u5fdc\u529b\u3092\u9ad8\u3081\u3066\u3044\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Bi, W., et al.<\/strong> (2009). <em>17p13.3 microduplications: a critical review of the genotype-phenotype correlations.<\/em> American Journal of Medical Genetics Part A.\n<ul class=\"wp-block-list\">\n<li>(\u203b17p13.3\u91cd\u8907\u75c7\u5019\u7fa4\u3092\u3001\u542b\u307e\u308c\u308b\u907a\u4f1d\u5b50\uff08YWHAE\u3068PAFAH1B1\uff09\u306b\u57fa\u3065\u3044\u3066\u30af\u30e9\u30b91\u30fb\u30af\u30e9\u30b92\u306b\u5206\u985e\u3057\u3001\u305d\u308c\u305e\u308c\u306e\u81e8\u5e8a\u7684\u7279\u5fb4\u3092\u8a73\u7d30\u306b\u5b9a\u7fa9\u3057\u305f\u3001\u672c\u75be\u60a3\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u6700\u3082\u91cd\u8981\u306a\u57fa\u790e\u8ad6\u6587\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Bruno, D.L., et al.<\/strong> (2010). <em>Further molecular and clinical delineation of co-locating 17p13.3 microdeletions and microduplications.<\/em> Journal of Medical Genetics.\n<ul class=\"wp-block-list\">\n<li>(\u203b\u6b20\u5931\u3068\u91cd\u8907\u306e\u6bd4\u8f03\u3001\u304a\u3088\u3073YWHAE\u907a\u4f1d\u5b50\u306e\u904e\u5270\u304c\u904e\u6210\u9577\u3084\u81ea\u9589\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u7814\u7a76\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Curry, C.J., et al.<\/strong> (2013). <em>Duplication of the LIS1 (PAFAH1B1) gene: A newly recognized cause of microcephaly and mild brain malformation?<\/em> American Journal of Medical Genetics.\n<ul class=\"wp-block-list\">\n<li>(\u203bPAFAH1B1\uff08LIS1\uff09\u907a\u4f1d\u5b50\u5358\u72ec\u306e\u91cd\u8907\u304c\u5c0f\u982d\u75c7\u3084\u8133\u5f62\u6210\u7570\u5e38\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f\u6587\u732e\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Roos, L., et al.<\/strong> (2009). <em>Complex chromosomal rearrangement of 17p13.3 involving a microduplication including YWHAE and a microdeletion including PAFAH1B1.<\/em>\n<ul class=\"wp-block-list\">\n<li>(\u203b\u8907\u96d1\u306a\u518d\u69cb\u6210\u306e\u75c7\u4f8b\u5831\u544a\u3092\u901a\u3058\u3066\u3001\u5404\u907a\u4f1d\u5b50\u306e\u7528\u91cf\u52b9\u679c\uff08Dosage effect\uff09\u3092\u8003\u5bdf\u3057\u305f\u7814\u7a76\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ClinGen Dosage Sensitivity Curation<\/strong>: <em>YWHAE<\/em> (Triplosensitivity score: 3 &#8211; Sufficient evidence), <em>PAFAH1B1<\/em> (Triplosensitivity score: 2\/3).\n<ul class=\"wp-block-list\">\n<li>(\u5404\u907a\u4f1d\u5b50\u304c\u91cd\u8907\uff083\u30b3\u30d4\u30fc\uff09\u306b\u306a\u308b\u3053\u3068\u3067\u75c5\u539f\u6027\u3092\u6301\u3064\u3053\u3068\u3092\u88cf\u4ed8\u3051\u308b\u5c02\u9580\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u8a55\u4fa1\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Unique (Rare Chromosome Disorder Support Group)<\/strong>: <em>17p13.3 microduplications<\/em> (2019).\n<ul class=\"wp-block-list\">\n<li>(\u60a3\u8005\u5bb6\u65cf\u5411\u3051\u306e\u5305\u62ec\u7684\u306a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3002)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<style>\n.entry-content li {\n  text-indent: -1rem !important;\n}\n<\/style>\n<p>\u8a73\u3057\u304f\u306f <a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/clinic\/\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u5168\u56fd\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e00\u89a7<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-16725","genetic-screening","type-genetic-screening","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/16725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/genetic-screening"}],"version-history":[{"count":4,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/16725\/revisions"}],"predecessor-version":[{"id":16831,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/16725\/revisions\/16831"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=16725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}