{"id":17251,"date":"2026-01-22T00:40:56","date_gmt":"2026-01-22T00:40:56","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?post_type=genetic-screening&#038;p=17251"},"modified":"2026-01-22T00:44:00","modified_gmt":"2026-01-22T00:44:00","slug":"chordoma","status":"publish","type":"genetic-screening","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/genetic-screening\/chordoma\/","title":{"rendered":"Chordoma"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u5225\u540d\u30fb\u95a2\u9023\u75be\u60a3\u540d<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u810a\u7d22\u816b\uff08\u65e5\u672c\u306b\u304a\u3051\u308b\u6b63\u5f0f\u306a\u8a3a\u65ad\u540d\uff09<\/li>\n\n\n\n<li>\u5bb6\u65cf\u6027\u810a\u7d22\u816b\uff08Familial Chordoma\uff09\n<ul class=\"wp-block-list\">\n<li>\u203b\u5bb6\u65cf\u5185\u3067\u8907\u6570\u540d\u304c\u767a\u75c7\u3059\u308b\u3001\u907a\u4f1d\u6027\u306e\u30b1\u30fc\u30b9\u3092\u6307\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u826f\u6027\u810a\u7d22\u7d30\u80de\u816b\uff08Benign Notochordal Cell Tumor; BNCT\uff09\n<ul class=\"wp-block-list\">\n<li>\u203b\u810a\u7d22\u816b\u306e\u524d\u6bb5\u968e\uff08\u524d\u99c6\u75c5\u5909\uff09\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u826f\u6027\u306e\u75c5\u5909\u3067\u3059\u3002\u810a\u7d22\u816b\u3068\u306e\u9451\u5225\u304c\u91cd\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Notochordal sarcoma\uff08\u810a\u7d22\u8089\u816b\uff09\n<ul class=\"wp-block-list\">\n<li>\u203b\u7a00\u306a\u547c\u79f0\u3067\u3059\u304c\u3001\u60aa\u6027\u816b\u760d\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u8abf\u3059\u308b\u5834\u5408\u306b\u4f7f\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5bfe\u8c61\u67d3\u8272\u4f53\u9818\u57df<\/strong><\/h2>\n\n\n\n<p><strong>6\u756a\u67d3\u8272\u4f53 \u9577\u8155\uff08q\uff0927\u9818\u57df<\/strong><\/p>\n\n\n\n<p>\u672c\u75be\u60a3\u306e\u767a\u751f\u306b\u306f\u3001\u30d2\u30c8\u306e6\u756a\u67d3\u8272\u4f53\u306e\u9577\u8155\uff08q\u30a2\u30fc\u30e0\uff09\u306e\u672b\u7aef\u306b\u8fd1\u3044\u300c27\u300d\u3068\u547c\u3070\u308c\u308b\u30d0\u30f3\u30c9\u9818\u57df\uff086q27\uff09\u306b\u4f4d\u7f6e\u3059\u308b\u3001**TBXT\u907a\u4f1d\u5b50\uff08\u65e7\u540d\uff1aT\u907a\u4f1d\u5b50\uff09**\u304c\u6c7a\u5b9a\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3010\u30b2\u30ce\u30e0\u4e0a\u306e\u8a73\u7d30\u3068\u300cBrachyury\uff08\u30d6\u30e9\u30ad\u30a6\u30ea\uff09\u300d\u3011<\/p>\n\n\n\n<p>\u3053\u306e\u75be\u60a3\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u6700\u3082\u91cd\u8981\u306a\u30ad\u30fc\u30ef\u30fc\u30c9\u304c\u3001**\u300cTBXT\u907a\u4f1d\u5b50\u300d\u3068\u3001\u305d\u3053\u304b\u3089\u4f5c\u3089\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u300cBrachyury\uff08\u30d6\u30e9\u30ad\u30a6\u30ea\uff09\u300d**\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Brachyury\u306e\u5f79\u5272:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Brachyury\u306f\u3001\u80ce\u5150\u304c\u767a\u751f\u3059\u308b\u6975\u3081\u3066\u521d\u671f\u306e\u6bb5\u968e\u3067\u3001\u300c\u810a\u7d22\uff08\u305b\u304d\u3055\u304f\uff09\u300d\u3068\u3044\u3046\u7d44\u7e54\u3092\u4f5c\u308b\u305f\u3081\u306b\u5fc5\u9808\u306e\u8ee2\u5199\u56e0\u5b50\uff08\u53f8\u4ee4\u5854\uff09\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u901a\u5e38\u3001\u810a\u7d22\u306f\u80cc\u9aa8\uff08\u810a\u690e\uff09\u304c\u5f62\u6210\u3055\u308c\u308b\u3068\u9000\u5316\u3057\u3066\u6d88\u5931\u3057\u3001\u690e\u9593\u677f\u306e\u4e2d\u5fc3\u90e8\uff08\u9ac4\u6838\uff09\u306b\u308f\u305a\u304b\u306b\u6b8b\u308b\u3060\u3051\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u305d\u306e\u305f\u3081\u3001\u51fa\u751f\u5f8c\u306e\u4eba\u9593\u306e\u7d44\u7e54\u3067\u306f\u3001\u3053\u306eBrachyury\u306f**\u300c\u767a\u73fe\u3057\u3066\u3044\u306a\u3044\uff08\u30b9\u30a4\u30c3\u30c1\u304c\u30aa\u30d5\u306b\u306a\u3063\u3066\u3044\u308b\uff09\u300d**\u306e\u304c\u6b63\u5e38\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u810a\u7d22\u816b\u306b\u304a\u3051\u308b\u7570\u5e38:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u810a\u7d22\u816b\u306e\u7d30\u80de\u3067\u306f\u3001\u306a\u305c\u304b\u3053\u306eBrachyury\u304c**\u904e\u5270\u306b\u767a\u73fe\uff08\u30b9\u30a4\u30c3\u30c1\u304c\u30aa\u30f3\uff09**\u3057\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u6027\u810a\u7d22\u816b:<\/strong> 6q27\u9818\u57df\u306e<em>TBXT<\/em>\u907a\u4f1d\u5b50\u304c**\u300c\u91cd\u8907\uff08\u30b3\u30d4\u30fc\u6570\u304c\u5897\u3048\u308b\uff09\u300d**\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5b64\u767a\u6027\uff08\u6563\u767a\u6027\uff09\u810a\u7d22\u816b:<\/strong> \u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306f\u907a\u4f1d\u6027\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\uff08SNP rs2305089\uff09\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u3001\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u767a\u751f\u983b\u5ea6<\/strong><\/h2>\n\n\n\n<p><strong>\u6975\u3081\u3066\u7a00\uff08Ultra-rare\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u983b\u5ea6:<\/strong> \u4eba\u53e3100\u4e07\u4eba\u3042\u305f\u308a\u5e74\u9593\u7d040.8\u301c1\u4eba\uff08<strong>100\u4e07\u4eba\u306b1\u4eba<\/strong>\uff09\u3068\u3044\u3046\u5e0c\u5c11\u304c\u3093\uff08\u8089\u816b\uff09\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5e74\u9f62:<\/strong> \u3042\u3089\u3086\u308b\u5e74\u9f62\u3067\u767a\u75c7\u3057\u307e\u3059\u304c\u3001<strong>50\u4ee3\u301c60\u4ee3<\/strong>\u306b\u30d4\u30fc\u30af\u304c\u3042\u308a\u307e\u3059\u3002\u5c0f\u5150\u3084\u82e5\u5e74\u8005\u3067\u306e\u767a\u75c7\u3082\u7a00\u306b\u3042\u308a\u3001\u305d\u306e\u5834\u5408\u306f\u982d\u84cb\u5e95\uff08\u982d\u306e\u9aa8\uff09\u306b\u767a\u751f\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u6027\u5dee:<\/strong> \u7537\u6027\u306e\u65b9\u304c\u5973\u6027\u3088\u308a\u3084\u3084\u591a\u304f\u767a\u75c7\u3057\u307e\u3059\uff08\u7537\uff1a\u5973 \uff1d \u7d04 2\uff1a1\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u81e8\u5e8a\u7684\u7279\u5fb4\uff08\u75c7\u72b6\uff09<\/strong><\/h2>\n\n\n\n<p>Chordoma\u306e\u6700\u5927\u306e\u7279\u5fb4\u306f\u3001**\u300c\u4f53\u306e\u4e2d\u5fc3\u7dda\uff08\u6b63\u4e2d\u7dda\uff09\u4e0a\u306e\u9aa8\u300d**\u306b\u767a\u751f\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306f\u3001\u767a\u751f\u6bcd\u5730\u3067\u3042\u308b\u300c\u810a\u7d22\u300d\u304c\u4f53\u306e\u4e2d\u5fc3\u8ef8\u306b\u3042\u308b\u7d44\u7e54\u3060\u304b\u3089\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u816b\u760d\u306f\u3086\u3063\u304f\u308a\u3068\u5897\u5927\u3059\u308b\u305f\u3081\u3001\u75c7\u72b6\u304c\u51fa\u308b\u9803\u306b\u306f\u304b\u306a\u308a\u5927\u304d\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u767a\u751f\u3059\u308b\u5834\u6240\u306b\u3088\u3063\u3066\u75c7\u72b6\u304c\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u982d\u84cb\u5e95\u810a\u7d22\u816b\uff08Skull Base Chordoma\uff09\uff1a\u7d0430\u301c35%<\/strong><\/p>\n\n\n\n<p>\u8133\u3092\u652f\u3048\u308b\u982d\u306e\u9aa8\u306e\u5e95\u3001\u300c\u659c\u53f0\uff08\u3057\u3083\u3060\u3044\uff09\u300d\u3068\u3044\u3046\u90e8\u5206\u306b\u3088\u304f\u3067\u304d\u307e\u3059\u3002\u8133\u795e\u7d4c\u3084\u8133\u5e79\u3092\u5727\u8feb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8907\u8996\uff08Double vision\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6700\u3082\u591a\u3044\u521d\u671f\u75c7\u72b6\u306e\u4e00\u3064\u3067\u3059\u3002\u773c\u3092\u52d5\u304b\u3059\u795e\u7d4c\uff08\u7279\u306b\u7b2c6\u8133\u795e\u7d4c\uff1a\u5916\u8ee2\u795e\u7d4c\uff09\u304c\u5727\u8feb\u3055\u308c\u3001\u773c\u7403\u304c\u5916\u5074\u306b\u52d5\u304b\u306a\u304f\u306a\u308a\u3001\u7269\u304c\u4e8c\u91cd\u306b\u898b\u3048\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u982d\u75db:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6df1\u3044\u90e8\u5206\u306e\u920d\u75db\u3084\u3001\u9996\u306e\u5f8c\u308d\u306e\u75db\u307f\u3092\u8a34\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u56a5\u4e0b\u969c\u5bb3\u30fb\u69cb\u97f3\u969c\u5bb3:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u98f2\u307f\u8fbc\u307f\u3084\u767a\u58f0\u306b\u95a2\u308f\u308b\u795e\u7d4c\u304c\u5727\u8feb\u3055\u308c\u308b\u3068\u3001\u98f2\u307f\u8fbc\u307f\u306b\u304f\u3044\u3001\u58f0\u304c\u308c\u3059\u308b\u306a\u3069\u306e\u75c7\u72b6\u304c\u51fa\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u9854\u9762\u306e\u3057\u3073\u308c\u30fb\u75db\u307f:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4e09\u53c9\u795e\u7d4c\u304c\u5727\u8feb\u3055\u308c\u308b\u3068\u3001\u9854\u306e\u611f\u899a\u304c\u920d\u304f\u306a\u3063\u305f\u308a\u3001\u75db\u307f\u304c\u51fa\u305f\u308a\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u4ed9\u9aa8\u810a\u7d22\u816b\uff08Sacral Chordoma\uff09\uff1a\u7d0450%<\/strong><\/p>\n\n\n\n<p>\u80cc\u9aa8\u306e\u4e00\u756a\u4e0b\u3001\u304a\u5c3b\u306e\u771f\u3093\u4e2d\u306b\u3042\u308b\u4e09\u89d2\u5f62\u306e\u9aa8\u300c\u4ed9\u9aa8\u300d\u306b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6162\u6027\u7684\u306a\u8170\u75db\u30fb\u81c0\u90e8\u75db:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u300c\u9577\u5f15\u304f\u8170\u75db\u300d\u300c\u5ea7\u308b\u3068\u5c3e\u3066\u3044\u9aa8\u304c\u75db\u3044\u300d\u3068\u3044\u3063\u305f\u75c7\u72b6\u304c\u51fa\u307e\u3059\u304c\u3001\u5750\u9aa8\u795e\u7d4c\u75db\u3084\u75d4\u3068\u9593\u9055\u308f\u308c\u3084\u3059\u304f\u3001\u767a\u898b\u304c\u9045\u308c\u308b\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6392\u4fbf\u30fb\u6392\u5c3f\u969c\u5bb3:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u308a\u3001\u4ed9\u9aa8\u306e\u4e2d\u3092\u901a\u308b\u795e\u7d4c\uff08\u99ac\u5c3e\u795e\u7d4c\uff09\u3092\u5727\u8feb\u3059\u308b\u3068\u3001\u4fbf\u79d8\u3001\u4fbf\u5931\u7981\u3001\u5c3f\u304c\u51fa\u306b\u304f\u3044\u3001\u5c3f\u6f0f\u308c\u306a\u3069\u306e\u75c7\u72b6\u304c\u73fe\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u6027\u6a5f\u80fd\u969c\u5bb3\uff08\u52c3\u8d77\u4e0d\u5168\u306a\u3069\uff09\u304c\u51fa\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4e0b\u80a2\u306e\u3057\u3073\u308c\u30fb\u8131\u529b:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8db3\u306e\u88cf\u3084\u592a\u3082\u3082\u306e\u88cf\u5074\u306b\u3057\u3073\u308c\u304c\u51fa\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u53ef\u52d5\u810a\u690e\u810a\u7d22\u816b\uff08Mobile Spine Chordoma\uff09\uff1a\u7d0415\u301c20%<\/strong><\/p>\n\n\n\n<p>\u9996\uff08\u981a\u690e\uff09\u3001\u80cc\u4e2d\uff08\u80f8\u690e\uff09\u3001\u8170\uff08\u8170\u690e\uff09\u306e\u9aa8\u306b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5c40\u6240\u306e\u75db\u307f:<\/strong> \u80cc\u4e2d\u3084\u9996\u306e\u75db\u307f\u3002<\/li>\n\n\n\n<li><strong>\u795e\u7d4c\u6839\u75c7\u72b6:<\/strong> \u8155\u3084\u8db3\u3078\u306e\u653e\u6563\u75db\uff08\u30d3\u30ea\u30d3\u30ea\u3059\u308b\u75db\u307f\uff09\u3002<\/li>\n\n\n\n<li><strong>\u810a\u9ac4\u5727\u8feb\u75c7\u72b6:<\/strong> \u9032\u884c\u3059\u308b\u3068\u810a\u9ac4\u304c\u5727\u8feb\u3055\u308c\u3001\u624b\u8db3\u306e\u9ebb\u75fa\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>4. \u75c5\u7406\u5b66\u7684\u7279\u5fb4\uff08Physaliphorous cells\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9855\u5fae\u93e1\u3067\u898b\u308b\u3068\u3001**\u300c\u6ce1\u6cab\u72b6\u7d30\u80de\uff08Physaliphorous cells\uff09\u300d**\u3068\u547c\u3070\u308c\u308b\u3001\u7d30\u80de\u8cea\u306b\u7a7a\u6ce1\uff08\u6ce1\u306e\u3088\u3046\u306a\u3082\u306e\uff09\u3092\u305f\u304f\u3055\u3093\u6301\u3063\u305f\u5927\u578b\u306e\u7d30\u80de\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u304c\u810a\u7d22\u816b\u306e\u8a3a\u65ad\u306e\u6c7a\u3081\u624b\u3068\u306a\u308b\u7279\u5fb4\u7684\u306a\u9854\u3064\u304d\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u539f\u56e0<\/strong><\/h2>\n\n\n\n<p><strong>\u810a\u7d22\uff08Notochord\uff09\u306e\u907a\u6b8b\u7d44\u7e54\u306e\u7570\u5e38\u5897\u6b96<\/strong>\u304c\u539f\u56e0\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u767a\u751f\u6a5f\u5e8f<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d2\u30c8\u306e\u80ce\u5150\u671f\u3001\u80cc\u9aa8\u304c\u3067\u304d\u308b\u524d\u306b\u3001\u4f53\u306e\u4e2d\u5fc3\u3092\u8cab\u304f\u300c\u810a\u7d22\u300d\u3068\u3044\u3046\u68d2\u72b6\u306e\u7d44\u7e54\u304c\u4f5c\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u304c\u80cc\u9aa8\u306e\u8a2d\u8a08\u56f3\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u901a\u5e38\u3001\u810a\u7d22\u306f\u5f79\u5272\u3092\u7d42\u3048\u308b\u3068\u9000\u5316\u3057\u3066\u6d88\u3048\u307e\u3059\uff08\u690e\u9593\u677f\u306e\u9ac4\u6838\u3068\u3057\u3066\u4e00\u90e8\u6b8b\u308b\u306e\u307f\uff09\u3002<\/li>\n\n\n\n<li>\u3057\u304b\u3057\u3001\u4f55\u3089\u304b\u306e\u539f\u56e0\u3067\u3001\u9aa8\u306e\u4e2d\u3084\u982d\u84cb\u5e95\u306b**\u300c\u810a\u7d22\u306e\u71c3\u3048\u304b\u3059\uff08\u907a\u6b8b\u7d44\u7e54\uff09\u300d**\u304c\u53d6\u308a\u6b8b\u3055\u308c\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u907a\u6b8b\u7d44\u7e54\u306b\u304a\u3044\u3066\u3001\u672c\u6765\u306f\u6b62\u307e\u3063\u3066\u3044\u308b\u306f\u305a\u306e**TBXT\u907a\u4f1d\u5b50\uff08Brachyury\uff09**\u304c\u518d\u3073\u66b4\u8d70\uff08\u904e\u5270\u767a\u73fe\uff09\u3057\u3001\u7d30\u80de\u5206\u88c2\u306e\u30b9\u30a4\u30c3\u30c1\u304c\u5165\u308b\u3053\u3068\u3067\u816b\u760d\u5316\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u907a\u4f1d\u7684\u8981\u56e0\uff08\u5bb6\u65cf\u6027\u3068\u5b64\u767a\u6027\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5b64\u767a\u6027\uff08Sporadic\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u307b\u3068\u3093\u3069\u306e\u60a3\u8005\u3055\u3093\uff0899%\u4ee5\u4e0a\uff09\u306f\u3053\u308c\u306b\u8a72\u5f53\u3057\u307e\u3059\u3002\u907a\u4f1d\u3057\u307e\u305b\u3093\u3002<\/li>\n\n\n\n<li>6q27\u9818\u57df\u306e\u907a\u4f1d\u5b50\u591a\u578b\uff08SNP\uff09\u304c\u767a\u75c7\u3057\u3084\u3059\u3055\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u57fa\u672c\u7684\u306b\u306f\u5076\u767a\u7684\u306a\u75c5\u6c17\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u6027\uff08Familial\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6975\u3081\u3066\u7a00\u3067\u3059\u304c\u3001\u4e16\u754c\u3067\u6570\u5bb6\u7cfb\u301c\u6570\u5341\u5bb6\u7cfb\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u5834\u5408\u3001**\u5e38\u67d3\u8272\u4f53\u9855\u6027\u907a\u4f1d\uff08\u512a\u6027\u907a\u4f1d\uff09**\u306e\u5f62\u5f0f\u3092\u3068\u308a\u3001<em>TBXT<\/em>\u907a\u4f1d\u5b50\u306e\u91cd\u8907\uff08Duplication\uff09\u304c\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8a3a\u65ad\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u753b\u50cf\u8a3a\u65ad\u3068\u3001\u78ba\u5b9a\u8a3a\u65ad\u306e\u305f\u3081\u306e\u751f\u691c\uff08\u7d44\u7e54\u691c\u67fb\uff09\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u753b\u50cf\u691c\u67fb\uff08MRI \/ CT\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>MRI:<\/strong> \u6700\u3082\u91cd\u8981\u306a\u691c\u67fb\u3067\u3059\u3002\u816b\u760d\u306e\u5e83\u304c\u308a\u3001\u795e\u7d4c\u3068\u306e\u95a2\u4fc2\u3001BNCT\uff08\u826f\u6027\u75c5\u5909\uff09\u3068\u306e\u9451\u5225\u306b\u5fc5\u9808\u3067\u3059\u3002T2\u5f37\u8abf\u753b\u50cf\u3068\u3044\u3046\u64ae\u5f71\u6cd5\u3067\u300c\u9ad8\u4fe1\u53f7\uff08\u767d\u304f\u5149\u308b\uff09\u300d\u3068\u306a\u308b\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>CT:<\/strong> \u9aa8\u304c\u3069\u306e\u3088\u3046\u306b\u7834\u58ca\u3055\u308c\u3066\u3044\u308b\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u751f\u691c\uff08Biopsy\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u816b\u760d\u306e\u4e00\u90e8\u3092\u91dd\u306a\u3069\u3067\u63a1\u53d6\u3057\u3001\u9855\u5fae\u93e1\u3067\u8abf\u3079\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u91cd\u8981:<\/strong> \u810a\u7d22\u816b\u306e\u624b\u8853\u306f\u975e\u5e38\u306b\u96e3\u3057\u3044\u305f\u3081\u3001\u751f\u691c\u306e\u91dd\u3092\u523a\u3059\u30eb\u30fc\u30c8\uff08\u7d4c\u8def\uff09\u306f\u3001\u5f8c\u306e\u624b\u8853\u3067\u4e00\u7dd2\u306b\u5207\u9664\u3067\u304d\u308b\u5834\u6240\u3092\u9078\u3076\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u5c02\u9580\u65bd\u8a2d\u3067\u306e\u5b9f\u65bd\u304c\u5f37\u304f\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u514d\u75ab\u67d3\u8272\uff08Immunohistochemistry\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u63a1\u53d6\u3057\u305f\u7d30\u80de\u3067\u3001**\u300cBrachyury\uff08\u30d6\u30e9\u30ad\u30a6\u30ea\uff09\u300d**\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u967d\u6027\uff08\u67d3\u307e\u308b\uff09\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u307e\u3059\u3002<\/li>\n\n\n\n<li>Brachyury\u304c\u967d\u6027\u3067\u3042\u308c\u3070\u3001\u307b\u307c\u9593\u9055\u3044\u306a\u304f\u810a\u7d22\u816b\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3059\uff08\u3053\u308c\u304c\u958b\u767a\u3055\u308c\u308b\u307e\u3067\u306f\u3001\u8edf\u9aa8\u8089\u816b\u3068\u306e\u533a\u5225\u304c\u56f0\u96e3\u3067\u3057\u305f\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u810a\u7d22\u816b\u306f\u3001\u4e00\u822c\u7684\u306a\u6297\u304c\u3093\u5264\u304c\u52b9\u304d\u306b\u304f\u304f\u3001\u653e\u5c04\u7dda\u6cbb\u7642\u3082\u901a\u5e38\u306eX\u7dda\u3067\u306f\u52b9\u679c\u304c\u4f4e\u3044**\u300c\u96e3\u6cbb\u6027\u816b\u760d\u300d\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001\u300c\u624b\u8853\u300d\u3068\u300c\u7c92\u5b50\u7dda\u6cbb\u7642\u300d**\u304c\u6cbb\u7642\u306e\u4e8c\u672c\u67f1\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u5916\u79d1\u7684\u624b\u8853\uff08Surgery\uff09<\/strong><\/p>\n\n\n\n<p><strong>\u6839\u6cbb\u3092\u76ee\u6307\u3059\u305f\u3081\u306e\u7b2c\u4e00\u9078\u629e\u3067\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4e00\u584a\u5207\u9664\uff08En bloc resection\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u816b\u760d\u3092\u30ab\u30d7\u30bb\u30eb\u3054\u3068\u3001\u5468\u308a\u306e\u6b63\u5e38\u306a\u7d44\u7e54\u3067\u5305\u307f\u8fbc\u3093\u3067\u3001\u3072\u3068\u304b\u305f\u307e\u308a\u3067\u53d6\u308a\u9664\u304f\u65b9\u6cd5\u304c\u7406\u60f3\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u816b\u760d\u306e\u4e2d\u3067\u5207\u3063\u305f\u308a\u3001\u63bb\u304d\u51fa\u3057\u305f\u308a\u3059\u308b\u3068\u3001\u305d\u3053\u304b\u3089\u518d\u767a\u3059\u308b\u30ea\u30b9\u30af\u304c\u6975\u3081\u3066\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u96e3\u6613\u5ea6:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u982d\u84cb\u5e95\u3084\u4ed9\u9aa8\u306f\u3001\u91cd\u8981\u306a\u795e\u7d4c\u3084\u8840\u7ba1\u304c\u5bc6\u96c6\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u5b8c\u5168\u5207\u9664\u304c\u975e\u5e38\u306b\u96e3\u3057\u3044\u5834\u6240\u3067\u3059\u3002\u5408\u4f75\u75c7\uff08\u795e\u7d4c\u9ebb\u75fa\u306a\u3069\uff09\u306e\u30ea\u30b9\u30af\u3068\u3001\u6839\u6cbb\u6027\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u719f\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u653e\u5c04\u7dda\u6cbb\u7642\uff08\u7279\u306b\u91cd\u7c92\u5b50\u7dda\u30fb\u967d\u5b50\u7dda\uff09<\/strong><\/p>\n\n\n\n<p><strong>\u810a\u7d22\u816b\u6cbb\u7642\u306e\u8981\uff08\u304b\u306a\u3081\uff09\u3067\u3059\u3002<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u901a\u5e38\u306e\u653e\u5c04\u7dda\uff08X\u7dda\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u810a\u7d22\u816b\u306f\u653e\u5c04\u7dda\u62b5\u6297\u6027\uff08\u52b9\u304d\u306b\u304f\u3044\uff09\u3067\u3042\u308a\u3001\u52b9\u304b\u305b\u308b\u305f\u3081\u306b\u306f\u5927\u91cf\u306e\u7dda\u91cf\u304c\u5fc5\u8981\u3067\u3059\u304c\u3001\u8fd1\u304f\u306b\u3042\u308b\u8133\u3084\u795e\u7d4c\u304c\u8010\u3048\u3089\u308c\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u7c92\u5b50\u7dda\u6cbb\u7642\uff08\u967d\u5b50\u7dda\u30fb\u91cd\u7c92\u5b50\u7dda\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u73fe\u5728\u3001<strong>\u6a19\u6e96\u6cbb\u7642<\/strong>\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u6c34\u7d20\u3084\u70ad\u7d20\u306e\u30a4\u30aa\u30f3\u3092\u52a0\u901f\u3057\u3066\u3076\u3064\u3051\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u72d9\u3063\u305f\u5834\u6240\uff08\u816b\u760d\uff09\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u7206\u767a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u5468\u308a\u306e\u795e\u7d4c\u3092\u5b88\u308a\u306a\u304c\u3089\u3001\u816b\u760d\u306b\u3060\u3051\u5f37\u529b\u306a\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u624b\u8853\u3067\u53d6\u308a\u304d\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u3084\u3001\u624b\u8853\u304c\u3067\u304d\u306a\u3044\u5834\u6240\u306b\u3042\u308b\u5834\u5408\u3001\u3042\u308b\u3044\u306f\u8853\u5f8c\u306e\u518d\u767a\u4e88\u9632\u3068\u3057\u3066\u884c\u308f\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u85ac\u7269\u7642\u6cd5\uff08Drug Therapy\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u810a\u7d22\u816b\u306b\u306f\u3001\u78ba\u7acb\u3055\u308c\u305f\u6a19\u6e96\u7684\u306a\u5316\u5b66\u7642\u6cd5\uff08\u6297\u304c\u3093\u5264\uff09\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n\n\n\n<li><strong>\u5206\u5b50\u6a19\u7684\u85ac:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u518d\u767a\u3084\u8ee2\u79fb\u304c\u3042\u308a\u3001\u624b\u8853\u3084\u653e\u5c04\u7dda\u304c\u3067\u304d\u306a\u3044\u5834\u5408\u3001<strong>\u30a4\u30de\u30c1\u30cb\u30d6\uff08Imatinib\uff09<\/strong>\u3001\u30a8\u30eb\u30ed\u30c1\u30cb\u30d6\u3001\u30a2\u30d5\u30a1\u30c1\u30cb\u30d6\u306a\u3069\u306e\u300c\u5206\u5b50\u6a19\u7684\u85ac\u300d\u304c\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff08\u4fdd\u967a\u9069\u5fdc\u5916\u4f7f\u7528\u3084\u6cbb\u9a13\u3068\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\uff09\u3002<\/li>\n\n\n\n<li>\u3053\u308c\u3089\u306f\u3001\u816b\u760d\u306e\u5897\u6b96\u306b\u95a2\u308f\u308b\u30b7\u30b0\u30ca\u30eb\uff08PDGFR\u3084EGFR\u306a\u3069\uff09\u3092\u30d6\u30ed\u30c3\u30af\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30cb\u30dc\u30eb\u30de\u30d6\u306a\u3069\u306e\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>4. \u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u60c5\u5831\u306e\u6574\u7406:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u300c\u5e0c\u5c11\u304c\u3093\u300d\u3067\u3042\u308a\u3001\u5c02\u9580\u7684\u306a\u60c5\u5831\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u6b63\u3057\u3044\u60c5\u5831\u306e\u63d0\u4f9b\u3068\u5fc3\u7406\u7684\u30b5\u30dd\u30fc\u30c8\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u6027\u3078\u306e\u5bfe\u5fdc:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u307b\u3068\u3093\u3069\u306f\u907a\u4f1d\u3057\u307e\u305b\u3093\u304c\u3001\u5bb6\u65cf\u5185\u306b\u8907\u6570\u306e\u810a\u7d22\u816b\u60a3\u8005\u304c\u3044\u308b\u5834\u5408\u306f\u3001\u907a\u4f1d\u5b66\u7684\u691c\u67fb\uff08TBXT\u907a\u4f1d\u5b50\u306e\u91cd\u8907\u306a\u3069\uff09\u3092\u691c\u8a0e\u3059\u308b\u610f\u7fa9\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>Chordoma\uff08\u810a\u7d22\u816b\uff09\u306f\u3001\u79c1\u305f\u3061\u304c\u751f\u307e\u308c\u308b\u524d\u3001\u304a\u6bcd\u3055\u3093\u306e\u304a\u8179\u306e\u4e2d\u306b\u3044\u305f\u9803\u306b\u80cc\u9aa8\u306e\u5143\u3068\u306a\u3063\u305f\u300c\u810a\u7d22\u300d\u3068\u3044\u3046\u7d44\u7e54\u306e\u7d30\u80de\u304c\u3001\u5927\u4eba\u306b\u306a\u3063\u3066\u3082\u6d88\u3048\u305a\u306b\u6b8b\u308a\u3001\u518d\u3073\u5897\u3048\u51fa\u3057\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u975e\u5e38\u306b\u73cd\u3057\u3044\u75c5\u6c17\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u75c5\u6c17\u306f\u3001\u982d\u306e\u5e95\u3084\u80cc\u9aa8\u3001\u304a\u5c3b\u306e\u9aa8\uff08\u4ed9\u9aa8\uff09\u306a\u3069\u3001\u4f53\u306e\u6df1\u3044\u4e2d\u5fc3\u90e8\u306b\u3067\u304d\u308b\u305f\u3081\u3001\u521d\u671f\u306e\u9803\u306f\u300c\u306a\u3093\u3068\u306a\u304f\u982d\u304c\u75db\u3044\u300d\u300c\u8170\u304c\u75db\u3044\u300d\u3068\u3044\u3063\u305f\u75c7\u72b6\u3067\u3001\u306a\u304b\u306a\u304b\u8a3a\u65ad\u304c\u3064\u304b\u306a\u3044\u3053\u3068\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u8a3a\u65ad\u3055\u308c\u305f\u6642\u3001\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306f\u300c\u805e\u3044\u305f\u3053\u3068\u3082\u306a\u3044\u75c5\u540d\u300d\u306b\u6238\u60d1\u3044\u3001\u624b\u8853\u306e\u96e3\u3057\u3055\u3084\u3001\u4e00\u822c\u7684\u306a\u6297\u304c\u3093\u5264\u304c\u52b9\u304d\u306b\u304f\u3044\u3068\u3044\u3046\u4e8b\u5b9f\u306b\u4e0d\u5b89\u3092\u611f\u3058\u3089\u308c\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u810a\u7d22\u816b\u306e\u6cbb\u7642\u306f\u8fd1\u5e74\u3001\u5927\u304d\u304f\u9032\u6b69\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8a3a\u65ad\u306b\u304a\u3044\u3066\u306f\u3001\u300cBrachyury\uff08\u30d6\u30e9\u30ad\u30a6\u30ea\uff09\u300d\u3068\u3044\u3046\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u767a\u898b\u306b\u3088\u308a\u3001\u6b63\u78ba\u306a\u8a3a\u65ad\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u6cbb\u7642\u306b\u304a\u3044\u3066\u306f\u3001\u300c\u91cd\u7c92\u5b50\u7dda\u300d\u3084\u300c\u967d\u5b50\u7dda\u300d\u3068\u3044\u3063\u305f\u5148\u9032\u7684\u306a\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u767b\u5834\u3057\u3001\u624b\u8853\u304c\u96e3\u3057\u3044\u5834\u6240\u306b\u3042\u308b\u816b\u760d\u306b\u5bfe\u3057\u3066\u3082\u3001\u5f37\u529b\u306a\u6cbb\u7642\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u624b\u8853\u6280\u8853\u3082\u5411\u4e0a\u3057\u3001\u8133\u795e\u7d4c\u5916\u79d1\u3084\u6574\u5f62\u5916\u79d1\u306e\u5c02\u9580\u533b\u304c\u30c1\u30fc\u30e0\u3092\u7d44\u3093\u3067\u3001\u6a5f\u80fd\u3092\u5b88\u308a\u306a\u304c\u3089\u816b\u760d\u3092\u53d6\u308a\u9664\u304f\u6311\u6226\u304c\u7d9a\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u75c5\u6c17\u306f\u3001\u518d\u767a\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u6cbb\u7642\u5f8c\u308210\u5e74\u300120\u5e74\u3068\u3044\u3046\u5358\u4f4d\u3067\u306e\u9577\u3044\u304a\u4ed8\u304d\u5408\u3044\uff08\u7d4c\u904e\u89b3\u5bdf\uff09\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5e0c\u5c11\u306a\u75be\u60a3\u3060\u304b\u3089\u3053\u305d\u3001\u810a\u7d22\u816b\u306e\u6cbb\u7642\u7d4c\u9a13\u304c\u8c4a\u5bcc\u306a\u5c02\u9580\u65bd\u8a2d\uff08\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u3084\u5927\u5b66\u75c5\u9662\uff09\u3092\u53d7\u8a3a\u3057\u3001\u30bb\u30ab\u30f3\u30c9\u30aa\u30d4\u30cb\u30aa\u30f3\u306a\u3069\u3092\u6d3b\u7528\u3057\u3066\u3001\u3054\u81ea\u8eab\u306b\u6700\u9069\u306a\u6cbb\u7642\u65b9\u91dd\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e3b\u6cbb\u533b\u3001\u5c02\u9580\u533b\u3001\u305d\u3057\u3066\u3054\u5bb6\u65cf\u3068\u5171\u306b\u3001\u6839\u6c17\u5f37\u304f\u75c5\u6c17\u3068\u5411\u304d\u5408\u3063\u3066\u3044\u304f\u9053\u306e\u308a\u3092\u3001\u533b\u7642\u30c1\u30fc\u30e0\u304c\u5168\u529b\u3067\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Vujovic, S., et al.<\/strong> (2006). <em>Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas.<\/em> Journal of Pathology.\n<ul class=\"wp-block-list\">\n<li>(\u203bBrachyury\u304c\u810a\u7d22\u816b\u306e\u7279\u7570\u7684\u306a\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u3001\u8a3a\u65ad\u7cbe\u5ea6\u3092\u5287\u7684\u306b\u5411\u4e0a\u3055\u305b\u305f\u753b\u671f\u7684\u306a\u8ad6\u6587\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Yang, X.R., et al.<\/strong> (2009). <em>T (brachyury) gene duplication confers major susceptibility to familial chordoma.<\/em> Nature Genetics.\n<ul class=\"wp-block-list\">\n<li>(\u203b\u5bb6\u65cf\u6027\u810a\u7d22\u816b\u306e\u539f\u56e0\u304cTBXT\u907a\u4f1d\u5b50\u306e\u91cd\u8907\u3067\u3042\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u305f\u3001\u907a\u4f1d\u5b66\u7684\u80cc\u666f\u306b\u95a2\u3059\u308b\u6700\u91cd\u8981\u6587\u732e\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Stacchiotti, S., et al.<\/strong> (2015). <em>Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.<\/em> Annals of Oncology.\n<ul class=\"wp-block-list\">\n<li>(\u203b\u4e16\u754c\u4e2d\u306e\u5c02\u9580\u5bb6\u306b\u3088\u308b\u3001\u810a\u7d22\u816b\u306e\u6cbb\u7642\u6307\u91dd\uff08\u624b\u8853\u3001\u653e\u5c04\u7dda\u3001\u85ac\u7269\u7642\u6cd5\uff09\u3092\u307e\u3068\u3081\u305f\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Pillay, N., et al.<\/strong> (2012). <em>A common single-nucleotide variant in T is strongly associated with chordoma.<\/em> Nature Genetics.\n<ul class=\"wp-block-list\">\n<li>(\u203b\u5b64\u767a\u6027\u810a\u7d22\u816b\u306b\u304a\u3044\u3066\u3082\u3001TBXT\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306eSNP\uff08\u4e00\u5869\u57fa\u591a\u578b\uff09\u304c\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5f37\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u7814\u7a76\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Chordoma Foundation<\/strong>: <em>Understanding Chordoma<\/em>.\n<ul class=\"wp-block-list\">\n<li>(\u203b\u60a3\u8005\u5411\u3051\u306b\u3001\u75be\u60a3\u306e\u57fa\u790e\u77e5\u8b58\u3001\u6700\u65b0\u306e\u6cbb\u7642\u6cd5\u3001\u81e8\u5e8a\u8a66\u9a13\u60c5\u5831\u306a\u3069\u3092\u63d0\u4f9b\u3059\u308b\u3001\u4e16\u754c\u6700\u5927\u306e\u60a3\u8005\u652f\u63f4\u56e3\u4f53\u306e\u60c5\u5831\u6e90\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>GeneReviews\u00ae [Internet]<\/strong>: <em>Chordoma<\/em>. Initial Posting: 2017. <em>Authors: Kelley MJ, et al.<\/em>\n<ul class=\"wp-block-list\">\n<li>(\u203b\u907a\u4f1d\u5b66\u7684\u80cc\u666f\u3001\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u5bb6\u65cf\u6027\u30ea\u30b9\u30af\u8a55\u4fa1\u306a\u3069\u3092\u7db2\u7f85\u3057\u305f\u5c02\u9580\u5bb6\u5411\u3051\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3002)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>WHO Classification of Tumours of Soft Tissue and Bone.<\/strong> (Latest Edition).\n<ul class=\"wp-block-list\">\n<li>(\u203b\u75c5\u7406\u8a3a\u65ad\u306e\u57fa\u6e96\u3068\u306a\u308bWHO\u5206\u985e\u3002\u810a\u7d22\u816b\u306e\u5b9a\u7fa9\u3084\u5206\u985e\uff08\u5f93\u6765\u578b\u3001\u8131\u5206\u5316\u578b\u306a\u3069\uff09\u306b\u3064\u3044\u3066\u8a18\u8ff0\u3002)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<style>\n.entry-content li {\n  text-indent: -1rem !important;\n}\n<\/style>\n<p>\u8a73\u3057\u304f\u306f <a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/clinic\/\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u5168\u56fd\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e00\u89a7<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-17251","genetic-screening","type-genetic-screening","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/17251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/genetic-screening"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/17251\/revisions"}],"predecessor-version":[{"id":17254,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/17251\/revisions\/17254"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=17251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}