{"id":17323,"date":"2026-01-22T02:25:06","date_gmt":"2026-01-22T02:25:06","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?post_type=genetic-screening&#038;p=17323"},"modified":"2026-01-22T02:28:22","modified_gmt":"2026-01-22T02:28:22","slug":"familial-adenomatous-polyposis","status":"publish","type":"genetic-screening","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/genetic-screening\/familial-adenomatous-polyposis\/","title":{"rendered":"Familial adenomatous polyposis"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u5225\u540d\u30fb\u95a2\u9023\u75be\u60a3\u540d<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FAP<\/strong>\uff08\u6700\u3082\u4e00\u822c\u7684\u306a\u7565\u79f0\uff09<\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u6027\u5927\u8178\u30dd\u30ea\u30dd\u30fc\u30b7\u30b9<\/strong><\/li>\n\n\n\n<li><strong>Gardner\u75c7\u5019\u7fa4\uff08\u30ac\u30fc\u30c9\u30ca\u30fc\u75c7\u5019\u7fa4\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u203b\u5927\u8178\u30dd\u30ea\u30dd\u30fc\u30b7\u30b9\u306b\u3001\u8edf\u90e8\u7d44\u7e54\u816b\u760d\uff08\u30c7\u30b9\u30e2\u30a4\u30c9\u816b\u760d\uff09\u3001\u9aa8\u816b\u3001\u56a2\u80de\u306a\u3069\u306e\u817a\u816b\u5916\u75c7\u72b6\u3092\u4f34\u3046\u5834\u5408\u306e\u547c\u79f0\u3067\u3059\u3002\u73fe\u5728\u3067\u306fFAP\u306e\u4e00\u3064\u306e\u8868\u73fe\u578b\u3068\u307f\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Turcot\u75c7\u5019\u7fa4\uff08\u30bf\u30fc\u30b3\u30c3\u30c8\u75c7\u5019\u7fa4\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u203b\u5927\u8178\u30dd\u30ea\u30dd\u30fc\u30b7\u30b9\u306b\u4e2d\u67a2\u795e\u7d4c\u7cfb\u816b\u760d\uff08\u9ac4\u82bd\u816b\u306a\u3069\uff09\u3092\u5408\u4f75\u3059\u308b\u5834\u5408\u306e\u547c\u79f0\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6e1b\u8870\u578b\u5bb6\u65cf\u6027\u5927\u8178\u817a\u816b\u75c7\uff08Attenuated FAP; AFAP\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u203b\u5927\u8178\u30dd\u30ea\u30fc\u30d7\u306e\u6570\u304c100\u500b\u672a\u6e80\u3068\u5c11\u306a\u304f\u3001\u767a\u75c7\u5e74\u9f62\u3082\u9045\u3044\u8efd\u75c7\u578b\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>MAP\uff08MUTYH\u95a2\u9023\u30dd\u30ea\u30dd\u30fc\u30b7\u30b9\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u203b\u81e8\u5e8a\u75c7\u72b6\u306f\u4f3c\u3066\u3044\u307e\u3059\u304c\u3001<em>MUTYH<\/em>\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306b\u3088\u308b\u5e38\u67d3\u8272\u4f53\u6f5c\u6027\uff08\u52a3\u6027\uff09\u907a\u4f1d\u5f62\u5f0f\u306e\u75be\u60a3\u3067\u3001FAP\u306e\u91cd\u8981\u306a\u9451\u5225\u75be\u60a3\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5bfe\u8c61\u67d3\u8272\u4f53\u9818\u57df<\/strong><\/h2>\n\n\n\n<p><strong>5\u756a\u67d3\u8272\u4f53 \u9577\u8155\uff08q\uff0922.2\u9818\u57df<\/strong><\/p>\n\n\n\n<p>\u672c\u75be\u60a3\u306f\u30015\u756a\u67d3\u8272\u4f53\u9577\u8155\u306e\u300c22.2\u300d\u3068\u3044\u3046\u4f4d\u7f6e\u306b\u5b58\u5728\u3059\u308b<strong>APC\u907a\u4f1d\u5b50<\/strong>\uff08Adenomatous Polyposis Coli\u907a\u4f1d\u5b50\uff09\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3010\u30b2\u30ce\u30e0\u4e0a\u306e\u8a73\u7d30\u3068APC\u907a\u4f1d\u5b50\u306e\u5f79\u5272\u3011<\/p>\n\n\n\n<p>APC\u907a\u4f1d\u5b50\u306f\u3001\u5f37\u529b\u306a**\u300c\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u300d**\u3067\u3059\u3002\u7d30\u80de\u306e\u5897\u6b96\u3092\u5236\u5fa1\u3059\u308b\u300cWnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u300d\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u30d6\u30ec\u30fc\u30ad\u5f79\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6b63\u5e38\u306a\u50cd\u304d:<\/strong> \u7d30\u80de\u5185\u306e\u03b2-\u30ab\u30c6\u30cb\u30f3\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u3057\u3001\u7d30\u80de\u304c\u5fc5\u8981\u4ee5\u4e0a\u306b\u5897\u6b96\u3059\u308b\u306e\u3092\u9632\u304e\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>FAP\u306e\u72b6\u614b:<\/strong> \u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u308a\u30d6\u30ec\u30fc\u30ad\u304c\u58ca\u308c\u308b\u3068\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u304c\u84c4\u7a4d\u3057\u3001\u5927\u8178\u7c98\u819c\u7d30\u80de\u304c\u7570\u5e38\u306b\u5897\u6b96\u3057\u3066\u300c\u817a\u816b\uff08\u30dd\u30ea\u30fc\u30d7\uff09\u300d\u304c\u591a\u767a\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u591a\u6bb5\u968e\u767a\u304c\u3093:<\/strong> FAP\u306e\u60a3\u8005\u69d8\u306f\u3001\u751f\u307e\u308c\u3064\u304d\u7247\u65b9\u306e<em>APC<\/em>\u907a\u4f1d\u5b50\u306b\u50b7\u304c\u3042\u308b\u305f\u3081\u3001\u3082\u3046\u7247\u65b9\u306e\u907a\u4f1d\u5b50\u306b\u50b7\u304c\u3064\u304f\u3068\uff08Second hit\uff09\u3001\u77ac\u304f\u9593\u306b\u30dd\u30ea\u30fc\u30d7\u304c\u304c\u3093\u5316\u3078\u3068\u7a81\u304d\u9032\u307f\u307e\u3059\u3002\u3053\u308c\u3092\u300cKnudson\u306e2\u30d2\u30c3\u30c8\u7406\u8ad6\u300d\u3068\u547c\u3073\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u767a\u751f\u983b\u5ea6<\/strong><\/h2>\n\n\n\n<p><strong>\u7d048,000\u4eba \u301c 17,000\u4eba\u306b1\u4eba<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6027\u5dee:<\/strong> \u7537\u5973\u5dee\u306f\u306a\u304f\u3001\u4eba\u7a2e\u3092\u554f\u308f\u305a\u767a\u75c7\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5927\u8178\u304c\u3093\u5168\u4f53\u306b\u304a\u3051\u308b\u5272\u5408:<\/strong> \u5168\u5927\u8178\u304c\u3093\u60a3\u8005\u306e\u7d041\uff05\u672a\u6e80\u3092\u5360\u3081\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u306e\u5272\u5408:<\/strong> \u7d0475\uff05\u301c80\uff05\u306f\u89aa\u304b\u3089\u306e\u907a\u4f1d\u3067\u3059\u304c\u3001\u6b8b\u308a\u306e\u7d0420\uff05\u301c25\uff05\u306f\u5bb6\u65cf\u306b\u75c5\u6b74\u304c\u306a\u3044**\u300c\u65b0\u751f\u7a81\u7136\u5909\u7570\u300d**\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u81e8\u5e8a\u7684\u7279\u5fb4\uff08\u75c7\u72b6\uff09<\/strong><\/h2>\n\n\n\n<p>FAP\u306e\u6700\u5927\u306e\u7279\u5fb4\u306f\u3001\u5927\u8178\u306b\u300c\u7d68\u6bef\uff08\u3058\u3085\u3046\u305f\u3093\uff09\u300d\u3092\u6577\u304d\u8a70\u3081\u305f\u3088\u3046\u306b\u767a\u751f\u3059\u308b\u5927\u91cf\u306e\u30dd\u30ea\u30fc\u30d7\u3067\u3059\u3002\u307e\u305f\u3001\u5927\u8178\u4ee5\u5916\u306b\u3082\u5168\u8eab\u306b\u3055\u307e\u3056\u307e\u306a\u75c5\u5909\u304c\u73fe\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u5927\u8178\u75c5\u5909<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u817a\u816b\uff08\u30dd\u30ea\u30fc\u30d7\uff09\u306e\u591a\u767a:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u601d\u6625\u671f\uff0810\u4ee3\u524d\u534a\uff09\u9803\u304b\u3089\u5927\u8178\u5185\u306b\u30dd\u30ea\u30fc\u30d7\u304c\u767a\u751f\u3057\u59cb\u3081\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5178\u578b\u4f8b:<\/strong> 100\u500b\u4ee5\u4e0a\u3001\u591a\u304f\u306f\u6570\u5343\u500b\u306b\u53ca\u3076\u30dd\u30ea\u30fc\u30d7\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u81ea\u899a\u75c7\u72b6:<\/strong> \u521d\u671f\u306f\u7121\u75c7\u72b6\u3067\u3059\u3002\u30dd\u30ea\u30fc\u30d7\u304c\u5897\u5927\u30fb\u304c\u3093\u5316\u3059\u308b\u3068\u3001\u8840\u4fbf\u3001\u4e0b\u75e2\u3001\u8179\u75db\u306a\u3069\u306e\u75c7\u72b6\u304c\u51fa\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5927\u8178\u304c\u3093\u3078\u306e\u9032\u884c:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6cbb\u7642\uff08\u5927\u8178\u5168\u6458\u8853\uff09\u3092\u884c\u308f\u306a\u3044\u5834\u5408\u3001<strong>40\u6b73\u307e\u3067\u306b\u7d0450\uff05\u300160\u6b73\u307e\u3067\u306b\u307b\u307c100\uff05\u306e\u78ba\u7387\u3067\u5927\u8178\u304c\u3093\u3092\u767a\u75c7<\/strong>\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u6d88\u5316\u7ba1\u306e\u817a\u816b\u5916\u75c5\u5909<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u80c3\u5e95\u817a\u30dd\u30ea\u30dd\u30fc\u30b7\u30b9:<\/strong> \u80c3\u306b\u591a\u6570\u306e\u826f\u6027\u30dd\u30ea\u30fc\u30d7\uff08\u80c3\u5e95\u817a\u30dd\u30ea\u30fc\u30d7\uff09\u304c\u3067\u304d\u307e\u3059\u304c\u3001\u304c\u3093\u5316\u306e\u30ea\u30b9\u30af\u306f\u6bd4\u8f03\u7684\u4f4e\u3044\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u5341\u4e8c\u6307\u8178\u817a\u816b\u30fb\u5341\u4e8c\u6307\u8178\u304c\u3093:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u60a3\u8005\u69d8\u306e\u7d0450\uff05\u301c90\uff05\u306b\u898b\u3089\u308c\u307e\u3059\u3002\u5927\u8178\u6458\u51fa\u5f8c\u306e\u60a3\u8005\u69d8\u306b\u304a\u3044\u3066\u3001\u4e3b\u8981\u306a\u6b7b\u56e0\u306e\u4e00\u3064\u3068\u306a\u308b\u305f\u3081\u3001\u5b9a\u671f\u7684\u306a\u80c3\u30ab\u30e1\u30e9\u691c\u67fb\u304c\u5fc5\u9808\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u7279\u306b\u5341\u4e8c\u6307\u8178\u4e73\u982d\u90e8\uff08\u80c6\u6c41\u306e\u51fa\u53e3\uff09\u4ed8\u8fd1\u306b\u3067\u304d\u3084\u3059\u304f\u3001\u304c\u3093\u5316\u306e\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u7279\u5fb4\u7684\u306a\u817a\u816b\u5916\u75c7\u72b6\uff08Gardner\u75c7\u5019\u7fa4\u306e\u8981\u7d20\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30c7\u30b9\u30e2\u30a4\u30c9\u816b\u760d:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8179\u58c1\u3084\u8179\u8154\u5185\uff08\u8178\u9593\u819c\uff09\u306b\u3067\u304d\u308b\u7dda\u7dad\u6027\u306e\u816b\u760d\u3067\u3059\u3002\u826f\u6027\u3067\u3059\u304c\u6d78\u6f64\u6027\u304c\u5f37\u304f\u3001\u8178\u9589\u585e\u3084\u8840\u7ba1\u5727\u8feb\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u5927\u8178\u5207\u9664\u624b\u8853\u5f8c\u306b\u767a\u751f\u3057\u3084\u3059\u304f\u3001FAP\u60a3\u8005\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u6700\u3082\u56f0\u96e3\u306a\u5408\u4f75\u75c7\u306e\u4e00\u3064\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u9aa8\u816b:<\/strong> \u4e0b\u984e\u9aa8\uff08\u3042\u3054\u306e\u9aa8\uff09\u306b\u3088\u304f\u898b\u3089\u308c\u3001\u6b6f\u79d1\u306e\u30ec\u30f3\u30c8\u30b2\u30f3\u3067\u5076\u7136\u767a\u898b\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8edf\u90e8\u7d44\u7e54\u816b\u760d:<\/strong> \u7c89\u7624\uff08\u30a2\u30c6\u30ed\u30fc\u30de\uff09\u3001\u7dda\u7dad\u816b\u3001\u8102\u80aa\u816b\u306a\u3069\u304c\u76ae\u819a\u306b\u591a\u767a\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>CHRPE\uff08\u5148\u5929\u6027\u7db2\u819c\u8272\u7d20\u4e0a\u76ae\u80a5\u5927\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7db2\u819c\u306b\u9ed2\u3044\u6591\u70b9\u304c\u898b\u3089\u308c\u308b\u3082\u306e\u3067\u3001\u8996\u529b\u306b\u306f\u5f71\u97ff\u3057\u307e\u305b\u3093\u304c\u3001FAP\u306e\u65e9\u671f\u8a3a\u65ad\u306b\u5f79\u7acb\u3064\u30b5\u30a4\u30f3\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u539f\u56e0<\/strong><\/h2>\n\n\n\n<p><strong>APC\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08\u5e38\u67d3\u8272\u4f53\u9855\u6027\u907a\u4f1d\u5f62\u5f0f\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5f62\u5f0f:<\/strong><strong>\u5e38\u67d3\u8272\u4f53\u9855\u6027\uff08\u512a\u6027\uff09\u907a\u4f1d<\/strong>\u3067\u3059\u3002\n<ul class=\"wp-block-list\">\n<li>\u89aa\u304cFAP\u306e\u5834\u5408\u3001\u7537\u5973\u554f\u308f\u305a\u5b50\u4f9b\u306b\u306f50\uff05\u306e\u78ba\u7387\u3067\u907a\u4f1d\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u3092\u53d7\u3051\u7d99\u3044\u3060\u5834\u5408\u3001\u307b\u307c\u78ba\u5b9f\u306b\uff08\u6d78\u900f\u7387\u307b\u307c100\uff05\uff09\u30dd\u30ea\u30dd\u30fc\u30b7\u30b9\u3092\u767a\u75c7\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u578b-\u8868\u73fe\u578b\u76f8\u95a2:<\/strong>\n<ul class=\"wp-block-list\">\n<li><em>APC<\/em>\u907a\u4f1d\u5b50\u306e\u300c\u3069\u306e\u90e8\u5206\u300d\u306b\u5909\u7570\u304c\u3042\u308b\u304b\u306b\u3088\u3063\u3066\u3001\u75c7\u72b6\u306e\u91cd\u3055\u3084\u30c7\u30b9\u30e2\u30a4\u30c9\u816b\u760d\u306e\u306a\u308a\u3084\u3059\u3055\u304c\u3042\u308b\u7a0b\u5ea6\u4e88\u6e2c\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\u3001\u907a\u4f1d\u5b50\u306e\u672b\u7aef\u5074\u306e\u5909\u7570\u306f\u300c\u6e1b\u8870\u578b\uff08AFAP\uff09\u300d\u306b\u306a\u308a\u3084\u3059\u3044\u3068\u3044\u3063\u305f\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8a3a\u65ad\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u81e8\u5e8a\u6240\u898b\uff08\u5185\u8996\u93e1\uff09\u3068\u5bb6\u7cfb\u5185\u3067\u306e\u767a\u75c7\u72b6\u6cc1\u3001\u305d\u3057\u3066\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5927\u8178\u5185\u8996\u93e1\u691c\u67fb\uff08\u30b3\u30ed\u30ce\u30b9\u30b3\u30d4\u30fc\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6700\u3082\u78ba\u5b9f\u306a\u691c\u67fb\u3067\u3059\u3002\u5927\u8178\u5185\u306b100\u500b\u4ee5\u4e0a\u306e\u30dd\u30ea\u30fc\u30d7\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u82e5\u5e74\u5c64\uff0810\u4ee3\uff09\u304b\u3089\u306e\u5b9a\u671f\u7684\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5bb6\u7cfb\u8abf\u67fb:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8840\u7e01\u8005\u306b\u5927\u8178\u304c\u3093\u3084\u591a\u767a\u30dd\u30ea\u30fc\u30d7\u306e\u60a3\u8005\u69d8\u304c\u3044\u306a\u3044\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u8840\u6db2\u304b\u3089DNA\u3092\u62bd\u51fa\u3057\u3001<em>APC<\/em>\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u8abf\u3079\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u672c\u4eba\u306e\u8a3a\u65ad\u78ba\u5b9a\u3060\u3051\u3067\u306a\u304f\u3001\u8840\u7e01\u8005\u304c\u5909\u7570\u3092\u53d7\u3051\u7d99\u3044\u3067\u3044\u308b\u304b\uff08\u672a\u767a\u75c7\u4fdd\u56e0\u8005\u306e\u8a3a\u65ad\uff09\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4e0a\u90e8\u6d88\u5316\u7ba1\u5185\u8996\u93e1\uff08\u80c3\u30ab\u30e1\u30e9\uff09:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u80c3\u3084\u5341\u4e8c\u6307\u8178\u306e\u75c5\u5909\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u5b9a\u671f\u7684\u306b\u884c\u308f\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<p>FAP\u306e\u6cbb\u7642\u306e\u57fa\u672c\u306f\u3001**\u300c\u5927\u8178\u304c\u3093\u306b\u306a\u308b\u524d\u306e\u4e88\u9632\u7684\u5927\u8178\u5207\u9664\u8853\u300d**\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u5916\u79d1\u7684\u624b\u8853\uff08\u5927\u8178\u5168\u6458\u8853\uff09<\/strong><\/p>\n\n\n\n<p>\u5927\u8178\u304c\u3093\u3092\u5b8c\u5168\u306b\u4e88\u9632\u3059\u308b\u305f\u3081\u3001\u30dd\u30ea\u30fc\u30d7\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u306a\u304f\u306a\u308b\u6642\u671f\uff08\u901a\u5e3810\u4ee3\u5f8c\u534a\u301c20\u4ee3\uff09\u306b\u624b\u8853\u3092\u691c\u8a0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5927\u8178\u5168\u6458\u30fb\u56de\u8178\u56a2\u809b\u9580\uff08\u7ba1\uff09\u543b\u5408\u8853\uff08IPAA \/ IAAA\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5927\u8178\uff08\u7d50\u8178\u3068\u76f4\u8178\uff09\u3092\u3059\u3079\u3066\u53d6\u308a\u9664\u304d\u3001\u5c0f\u8178\uff08\u56de\u8178\uff09\u3067\u4fbf\u3092\u6e9c\u3081\u308b\u888b\uff08\u56de\u8178\u56a2\uff09\u3092\u4f5c\u3063\u3066\u809b\u9580\u306b\u3064\u306a\u3050\u65b9\u6cd5\u3067\u3059\u3002\u4eba\u5de5\u809b\u9580\u306b\u306a\u3089\u305a\u306b\u3001\u81ea\u7136\u306a\u6392\u4fbf\u6a5f\u80fd\u3092\u6b8b\u305b\u308b\u305f\u3081\u3001\u73fe\u5728\u306e\u6a19\u6e96\u7684\u306a\u8853\u5f0f\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u7d50\u8178\u5168\u6458\u30fb\u56de\u8178\u76f4\u8178\u543b\u5408\u8853\uff08IRA\uff09\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u76f4\u8178\u306e\u30dd\u30ea\u30fc\u30d7\u304c\u5c11\u306a\u3044\u5834\u5408\u306b\u3001\u76f4\u8178\u3092\u6b8b\u3057\u3066\u5c0f\u8178\u3092\u3064\u306a\u3050\u65b9\u6cd5\u3067\u3059\u3002\u624b\u8853\u306f\u6bd4\u8f03\u7684\u5bb9\u6613\u3067\u3059\u304c\u3001\u6b8b\u3063\u305f\u76f4\u8178\u304b\u3089\u304c\u3093\u304c\u3067\u304d\u308b\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u8853\u5f8c\u306e\u53b3\u91cd\u306a\u5185\u8996\u93e1\u30c1\u30a7\u30c3\u30af\u304c\u5fc5\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u5185\u8996\u93e1\u7684\u6cbb\u7642<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5341\u4e8c\u6307\u8178\u306e\u30dd\u30ea\u30fc\u30d7\u306b\u5bfe\u3057\u3066\u306f\u3001\u5927\u304d\u304f\u306a\u3063\u305f\u3082\u306e\u3084\u764c\u5316\u304c\u7591\u308f\u308c\u308b\u3082\u306e\u3092\u5185\u8996\u93e1\u3067\u5207\u9664\uff08EMR\/ESD\uff09\u3057\u3001\u7d4c\u904e\u3092\u89b3\u5bdf\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u85ac\u7269\u7642\u6cd5\uff08\u5316\u5b66\u4e88\u9632\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NSAIDs\uff08\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac\uff09:<\/strong> \u30b9\u30ea\u30f3\u30c0\u30af\u3084\u30bb\u30ec\u30b3\u30ad\u30b7\u30d6\u306a\u3069\u304c\u3001\u30dd\u30ea\u30fc\u30d7\u306e\u6570\u3092\u4e00\u6642\u7684\u306b\u6e1b\u3089\u3059\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u304c\u3093\u306e\u4e88\u9632\u52b9\u679c\u306f\u5b8c\u5168\u3067\u306f\u306a\u304f\u3001\u3042\u304f\u307e\u3067\u624b\u8853\u307e\u3067\u306e\u5f85\u6a5f\u671f\u9593\u306e\u88dc\u52a9\u7684\u306a\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30c7\u30b9\u30e2\u30a4\u30c9\u816b\u760d\u306e\u6cbb\u7642:<\/strong> \u6297\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u85ac\u3001NSAIDs\u3001\u5206\u5b50\u6a19\u7684\u85ac\u3001\u3042\u308b\u3044\u306f\u4f4e\u7528\u91cf\u6297\u304c\u3093\u5264\u304c\u691c\u8a0e\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>4. \u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\uff08\u8853\u5f8c\u306e\u5b9a\u671f\u691c\u67fb\uff09<\/strong><\/p>\n\n\n\n<p>\u624b\u8853\u3092\u3057\u3066\u7d42\u308f\u308a\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6b8b\u5b58\u76f4\u8178\u30fb\u56de\u8178\u56a2\u306e\u691c\u67fb:<\/strong> \u5e741\u301c2\u56de\u3001\u5185\u8996\u93e1\u3067\u30c1\u30a7\u30c3\u30af\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u4e0a\u90e8\u6d88\u5316\u7ba1\u691c\u67fb:<\/strong> 1\u301c3\u5e74\u3054\u3068\u306b\u80c3\u30fb\u5341\u4e8c\u6307\u8178\u306e\u30c1\u30a7\u30c3\u30af\u3092\u884c\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0<\/strong><\/h2>\n\n\n\n<p>FAP\u306f\u300c\u5bb6\u65cf\u306e\u75c5\u6c17\u300d\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u672a\u767a\u75c7\u306e\u8840\u7e01\u8005\u3078\u306e\u652f\u63f4:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u304a\u5b50\u69d8\u304c\u5909\u7570\u3092\u53d7\u3051\u7d99\u3044\u3067\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u77e5\u308b\u3053\u3068\u3067\u3001\u9069\u5207\u306a\u6642\u671f\u304b\u3089\u5b9a\u671f\u691c\u67fb\u3092\u59cb\u3081\u3001\u304c\u3093\u306b\u306a\u308b\u306e\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5fc3\u7406\u7684\u30b5\u30dd\u30fc\u30c8:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u3078\u306e\u4e0d\u5b89\u3001\u624b\u8853\u3078\u306e\u845b\u85e4\u3001\u82e5\u5e74\u3067\u306e\u767a\u75c7\u306b\u5bfe\u3059\u308b\u7cbe\u795e\u7684\u30b1\u30a2\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u51fa\u751f\u524d\u8a3a\u65ad\u30fb\u7740\u5e8a\u524d\u8a3a\u65ad:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5e0c\u671b\u3055\u308c\u308b\u5834\u5408\u306b\u306f\u3001\u5c02\u9580\u306e\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u3068\u306e\u76f8\u8ac7\u304c\u5fc5\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>Familial adenomatous polyposis (FAP) \u306f\u3001\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3067\u5927\u8178\u306b\u5927\u91cf\u306e\u30dd\u30ea\u30fc\u30d7\u304c\u3067\u304d\u3001\u653e\u7f6e\u3059\u308b\u3068\u5c06\u6765\u7684\u306b\u5fc5\u305a\u5927\u8178\u304c\u3093\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u75c5\u6c17\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u300c\u304c\u3093\u306b\u306a\u308b\u78ba\u7387\u304c100\uff05\u300d\u3068\u805e\u304f\u3068\u3001\u975e\u5e38\u306b\u6050\u308d\u3057\u304f\u611f\u3058\u3089\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u8996\u70b9\u3092\u5909\u3048\u308c\u3070\u3001**\u300c\u9069\u5207\u306b\u691c\u67fb\u3092\u53d7\u3051\u3001\u9069\u5207\u306a\u6642\u671f\u306b\u624b\u8853\u3092\u3059\u308c\u3070\u3001\u78ba\u5b9f\u306b\u304c\u3093\u3092\u9632\u3052\u308b\u75c5\u6c17\u300d**\u3067\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u73fe\u4ee3\u306e\u533b\u5b66\u3067\u306f\u300110\u4ee3\u304b\u3089\u5b9a\u671f\u7684\u306b\u30ab\u30e1\u30e9\u691c\u67fb\u3092\u884c\u3044\u3001\u304c\u3093\u304c\u3067\u304d\u308b\u524d\u306b\u4e88\u9632\u7684\u624b\u8853\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u591a\u304f\u306e\u60a3\u8005\u69d8\u304c\u666e\u901a\u306e\u65b9\u3068\u5909\u308f\u3089\u306a\u3044\u5bff\u547d\u3092\u5168\u3046\u3057\u3001\u793e\u4f1a\u3067\u6d3b\u8e8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3054\u81ea\u8eab\u3084\u3054\u5bb6\u65cf\u304cFAP\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3089\u3001\u4e00\u4eba\u3067\u62b1\u3048\u8fbc\u307e\u305a\u3001\u907a\u4f1d\u533b\u7642\u306e\u5c02\u9580\u30c1\u30fc\u30e0\u3084\u5916\u79d1\u533b\u3068\u624b\u3092\u53d6\u308a\u5408\u3044\u307e\u3057\u3087\u3046\u3002\u6b63\u3057\u3044\u77e5\u8b58\u3092\u6301\u3061\u3001\u5b9a\u671f\u7684\u306a\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u3092\u7d9a\u3051\u3066\u3044\u304f\u3053\u3068\u304c\u3001\u5065\u3084\u304b\u306a\u672a\u6765\u3092\u5b88\u308b\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Bussey, H. J.<\/strong> (1975). <em>Familial polyposis coli. Family studies, histopathology, differential diagnosis, and skeletal anomalies.<\/em> Johns Hopkins University Press.\n<ul class=\"wp-block-list\">\n<li>\uff08FAP\u306e\u81e8\u5e8a\u50cf\u3068\u907a\u4f1d\u5b66\u7684\u7279\u5fb4\u3092\u4f53\u7cfb\u5316\u3057\u305f\u8a18\u5ff5\u7891\u7684\u8457\u4f5c\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Groden, J., et al.<\/strong> (1991). <em>Identification and characterization of the familial adenomatous polyposis coli gene.<\/em> Cell.\n<ul class=\"wp-block-list\">\n<li>\uff08\u539f\u56e0\u907a\u4f1d\u5b50APC\u306e\u7279\u5b9a\u306b\u95a2\u3059\u308b\u539f\u8457\u8ad6\u6587\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Kinzler, K. W., et al.<\/strong> (1991). <em>Identification of a gene located at chromosome 5q21 that is mutated in colorectal adenomas and carcinomas.<\/em> Science.\n<ul class=\"wp-block-list\">\n<li>\uff08\u540c\u6642\u671f\u306bAPC\u907a\u4f1d\u5b50\u306e\u91cd\u8981\u6027\u3092\u5831\u544a\u3057\u305f\u91cd\u8981\u6587\u732e\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Jasperson, K. W., et al.<\/strong> (2017). <em>APC-Associated Adenomatous Polyposis.<\/em> GeneReviews\u00ae [Internet].\n<ul class=\"wp-block-list\">\n<li>\uff08\u6700\u65b0\u306e\u7ba1\u7406\u6307\u91dd\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3001\u8a3a\u65ad\u57fa\u6e96\u3092\u7db2\u7f85\u3057\u305f\u4e16\u754c\u7684\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u65e5\u672c\u907a\u4f1d\u6027\u816b\u760d\u5b66\u4f1a<\/strong>: <em>\u907a\u4f1d\u6027\u5927\u8178\u304c\u3093\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3 2024<\/em>.\n<ul class=\"wp-block-list\">\n<li>\uff08\u65e5\u672c\u56fd\u5185\u306b\u304a\u3051\u308b\u6700\u65b0\u306e\u6a19\u6e96\u7684\u8a3a\u7642\u6307\u91dd\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Lynch, H. T., et al.<\/strong> (2003). <em>Hereditary colorectal cancer.<\/em> New England Journal of Medicine.\n<ul class=\"wp-block-list\">\n<li>\uff08\u907a\u4f1d\u6027\u5927\u8178\u304c\u3093\u5168\u4f53\u306e\u30aa\u30fc\u30d0\u30fc\u30d3\u30e5\u30fc\u3068FAP\u306e\u4f4d\u7f6e\u3065\u3051\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<style>\n.entry-content li {\n  text-indent: -1rem !important;\n}\n<\/style>\n<p>\u8a73\u3057\u304f\u306f <a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/clinic\/\">\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u5168\u56fd\u306e\u30af\u30ea\u30cb\u30c3\u30af\u4e00\u89a7<\/a> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-17323","genetic-screening","type-genetic-screening","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/17323","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/genetic-screening"}],"version-history":[{"count":4,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/17323\/revisions"}],"predecessor-version":[{"id":17329,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/genetic-screening\/17323\/revisions\/17329"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=17323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}