{"id":10032,"date":"2025-03-14T08:28:43","date_gmt":"2025-03-14T08:28:43","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10032"},"modified":"2025-03-14T08:28:44","modified_gmt":"2025-03-14T08:28:44","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%a1%80%e5%9c%a7%ef%bc%9a%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%97%a9%e6%9c%9f%e7%99%ba%e8%a6%8b%e3%81%a8%e5%af%be%e5%bf%9c%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%a1%80%e5%9c%a7%ef%bc%9a%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e6%97%a9%e6%9c%9f%e7%99%ba%e8%a6%8b%e3%81%a8%e5%af%be%e5%bf%9c%e6%b3%95\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u8840\u5727\uff1a\u30ea\u30b9\u30af\u306e\u65e9\u671f\u767a\u898b\u3068\u5bfe\u5fdc\u6cd5"},"content":{"rendered":"\n<p>\u8840\u5727\u306f\u907a\u4f1d\u3068\u74b0\u5883\u8981\u56e0\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u8907\u96d1\u306a\u751f\u7406\u6a5f\u80fd\u3067\u3059\u3002\u7279\u306b\u9ad8\u8840\u5727\u306f\u3001\u4e16\u754c\u4e2d\u3067\u591a\u304f\u306e\u4eba\u3005\u304c\u62b1\u3048\u308b\u5065\u5eb7\u30ea\u30b9\u30af\u3067\u3042\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u305d\u306e\u767a\u75c7\u306b\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u30b2\u30ce\u30e0\u7814\u7a76\u306b\u3088\u308a\u3001\u9ad8\u8840\u5727\u3068\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u304c\u591a\u6570\u7279\u5b9a\u3055\u308c\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u53ef\u80fd\u6027\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u8840\u5727\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u3092\u8a73\u3057\u304f\u89e3\u8aac\u3057\u3001\u30ea\u30b9\u30af\u306e\u65e9\u671f\u767a\u898b\u65b9\u6cd5\u3084\u5bfe\u5fdc\u7b56\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u8840\u5727\u3068\u907a\u4f1d\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u8840\u5727\u306f\u3001\u5fc3\u81d3\u304c\u8840\u6db2\u3092\u9001\u308a\u51fa\u3059\u529b\u3068\u8840\u7ba1\u306e\u62b5\u6297\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8981\u56e0\u306f\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u90e8\u5206\u7684\u306b\u5236\u5fa1\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u5909\u7570\u304c\u9ad8\u8840\u5727\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u7387\u3068\u306f\uff1f<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u7387\u3068\u306f\u3001\u3042\u308b\u7279\u6027\u304c\u3069\u306e\u7a0b\u5ea6\u907a\u4f1d\u306b\u3088\u3063\u3066\u8aac\u660e\u3067\u304d\u308b\u304b\u3092\u793a\u3059\u6307\u6a19\u3067\u3059\u3002\u9ad8\u8840\u5727\u306e\u907a\u4f1d\u7387\u306f30\uff5e50%\u3068\u63a8\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u74b0\u5883\u8981\u56e0\uff08\u98df\u751f\u6d3b\u3084\u904b\u52d5\u7fd2\u6163\uff09\u3068\u4e26\u3093\u3067\u907a\u4f1d\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9ad8\u8840\u5727\u3068\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u7814\u7a76<\/strong><\/h3>\n\n\n\n<p>\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u306b\u3088\u308a\u3001\u591a\u304f\u306e\u907a\u4f1d\u5b50\u304c\u8840\u5727\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u4ee5\u4e0b\u306b\u3001\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u9ad8\u8840\u5727\u306b\u95a2\u9023\u3059\u308b\u4e3b\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\uff08AGT\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>AGT\u907a\u4f1d\u5b50\u306f\u3001\u8840\u5727\u3092\u8abf\u7bc0\u3059\u308b\u30db\u30eb\u30e2\u30f3\u300c\u30ec\u30cb\u30f3-\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\uff08RAS\uff09\u300d\u306e\u4e00\u90e8\u3092\u69cb\u6210\u3059\u308b\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\u306e\u751f\u6210\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\uff08M235T\u5909\u7570\uff09\u304c\u9ad8\u8840\u5727\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff08ACE\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>ACE\u907a\u4f1d\u5b50\u306f\u3001\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3I\u3092\u8840\u7ba1\u53ce\u7e2e\u4f5c\u7528\u306e\u5f37\u3044\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u306b\u5909\u63db\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u633f\u5165\/\u6b20\u5931\uff08I\/D\uff09\u591a\u578b\u304c\u8840\u5727\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. ATP2B1\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>ATP2B1\u907a\u4f1d\u5b50\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u8f38\u9001\u3092\u5236\u5fa1\u3057\u3001\u8840\u7ba1\u306e\u53ce\u7e2e\u3084\u5f1b\u7de9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002GWAS\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u3068\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. NPPA\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>NPPA\u907a\u4f1d\u5b50\u306f\u3001\u5fc3\u81d3\u3067\u5408\u6210\u3055\u308c\u308b\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9\uff08ANP\uff09\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u8840\u7ba1\u306e\u62e1\u5f35\u3084\u30ca\u30c8\u30ea\u30a6\u30e0\u6392\u51fa\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u8840\u5727\u306e\u8abf\u7bc0\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u306e\u65e9\u671f\u767a\u898b<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/24056100_m-1024x681.jpg\" alt=\"\" class=\"wp-image-10047\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24056100_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24056100_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24056100_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24056100_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/24056100_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u3092\u89e3\u6790\u3059\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u666e\u53ca\u3057\u3001\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u30e1\u30ea\u30c3\u30c8<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u65e9\u671f\u767a\u898b<\/strong>\uff1a\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3092\u65e9\u3081\u306b\u958b\u59cb\u3067\u304d\u308b\u3002<\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u533b\u7642<\/strong>\uff1a\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u304d\u3001\u3088\u308a\u9069\u5207\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3067\u304d\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5bb6\u65cf\u3078\u306e\u5f71\u97ff<\/strong>\uff1a\u5bb6\u65cf\u306b\u3082\u540c\u69d8\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u4e88\u9632\u7b56\u3092\u691c\u8a0e\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u4e00\u822c\u7684\u306b\u4ee5\u4e0b\u306e\u624b\u9806\u3067\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u553e\u6db2\u3084\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u5b9f\u65bd<\/li>\n\n\n\n<li>\u9ad8\u8840\u5727\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u7279\u5b9a<\/li>\n\n\n\n<li>\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u4e88\u9632\u7b56\u3092\u63d0\u6848<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306b\u57fa\u3065\u304f\u9ad8\u8840\u5727\u306e\u5bfe\u5fdc\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u9ad8\u8840\u5727\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u6301\u3064\u5834\u5408\u3067\u3082\u3001\u9069\u5207\u306a\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u3067\u767a\u75c7\u3092\u9632\u3050\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6e1b\u5869<\/strong>\uff1a\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u6442\u53d6\u91cf\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u8840\u5727\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3002<\/li>\n\n\n\n<li><strong>\u9069\u5ea6\u306a\u904b\u52d5<\/strong>\uff1a\u6709\u9178\u7d20\u904b\u52d5\u3092\u5b9a\u671f\u7684\u306b\u884c\u3046\u3053\u3068\u3067\u8840\u5727\u306e\u5b89\u5b9a\u3092\u4fc3\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong>\uff1a\u7791\u60f3\u3084\u6df1\u547c\u5438\u3092\u53d6\u308a\u5165\u308c\u3001\u81ea\u5f8b\u795e\u7d4c\u3092\u6574\u3048\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u85ac\u7269\u7642\u6cd5\u306e\u500b\u5225\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304d\u3001\u6700\u9069\u306a\u964d\u5727\u5264\u3092\u9078\u629e\u3059\u308b\u500b\u5225\u5316\u533b\u7642\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001ACE\u907a\u4f1d\u5b50\u306b\u95a2\u9023\u3059\u308b\u9ad8\u8840\u5727\u306b\u306fACE\u963b\u5bb3\u85ac\u304c\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u8840\u5727\u8abf\u7bc0<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1024x683.jpg\" alt=\"\u5869\u30b5\u30d0\u5b9a\u98df\" class=\"wp-image-9733\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/5080812_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u306f\u3001DNA\u914d\u5217\u306e\u5909\u5316\u3092\u4f34\u308f\u305a\u306b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u98df\u4e8b\u3084\u904b\u52d5\u3001\u74b0\u5883\u8981\u56e0\u304c\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8840\u5727\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5f71\u97ff\u3092\u53d7\u3051\u308b\u8981\u56e0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6804\u990a\u72b6\u614b<\/strong>\uff08\u7279\u5b9a\u306e\u30d3\u30bf\u30df\u30f3\u3084\u30df\u30cd\u30e9\u30eb\u306e\u6442\u53d6\uff09<\/li>\n\n\n\n<li><strong>\u904b\u52d5\u7fd2\u6163<\/strong>\uff08\u9069\u5ea6\u306a\u904b\u52d5\u304c\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u6574\uff09<\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9<\/strong>\uff08\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5f71\u97ff\uff09<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u6700\u65b0\u306e\u7814\u7a76\u7d50\u679c\u3068\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u3068\u9ad8\u8840\u5727\u306e\u95a2\u9023\u6027\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/ng.784\">Genome-wide association studies identify multiple loci associated with blood pressure<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3549197\/\">Genetic variants in the renin-angiotensin system and their impact on hypertension<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0163725819301559\">Epigenetic modifications and their role in hypertension<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8003\u616e\u3057\u305f\u98df\u4e8b\u7642\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u9ad8\u8840\u5727\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u6301\u3064\u5834\u5408\u3001\u9069\u5207\u306a\u98df\u4e8b\u7642\u6cd5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u307e\u3059\u3002\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u6804\u990a\u5b66\uff08\u30cb\u30e5\u30fc\u30c8\u30ea\u30b2\u30ce\u30df\u30af\u30b9\uff09\u306f\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u306b\u9069\u3057\u305f\u98df\u4e8b\u3092\u9078\u629e\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u5206\u91ce\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>DASH\u98df\u3068\u907a\u4f1d\u7684\u9069\u5fdc<\/strong><\/h3>\n\n\n\n<p>DASH\uff08Dietary Approaches to Stop Hypertension\uff09\u98df\u306f\u3001\u9ad8\u8840\u5727\u306e\u4e88\u9632\u3068\u7ba1\u7406\u306b\u6709\u52b9\u306a\u98df\u4e8b\u7642\u6cd5\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8003\u616e\u3057\u306a\u304c\u3089\u4ee5\u4e0b\u306e\u30dd\u30a4\u30f3\u30c8\u3092\u610f\u8b58\u3059\u308b\u3068\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u8840\u5727\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ab\u30ea\u30a6\u30e0\u306e\u6442\u53d6\u3092\u5897\u3084\u3059<\/strong>\uff08ATP2B1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u7279\u306b\u91cd\u8981\uff09<\/li>\n\n\n\n<li><strong>\u5869\u5206\u611f\u53d7\u6027\u306b\u5fdc\u3058\u305f\u30ca\u30c8\u30ea\u30a6\u30e0\u5236\u9650<\/strong>\uff08ACE\u907a\u4f1d\u5b50\u5909\u7570\u306e\u3042\u308b\u4eba\u306f\u5869\u5206\u306b\u654f\u611f\uff09<\/li>\n\n\n\n<li><strong>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8003\u3048\u308b<\/strong>\uff08\u8840\u7ba1\u306e\u5065\u5eb7\u3092\u7dad\u6301\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u5225\u306e\u98df\u4e8b\u63a8\u5968<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u98df\u4e8b<\/strong><\/td><\/tr><tr><td><strong>ACE<\/strong><\/td><td>\u5869\u5206\u611f\u53d7\u6027\u304c\u9ad8\u3044<\/td><td>\u6e1b\u5869\u98df\u3001\u30ab\u30ea\u30a6\u30e0\u30fb\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u8c4a\u5bcc\u306a\u98df\u4e8b<\/td><\/tr><tr><td><strong>AGT<\/strong><\/td><td>\u30ec\u30cb\u30f3-\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u306e\u6d3b\u6027\u304c\u9ad8\u3044<\/td><td>\u6297\u9178\u5316\u7269\u8cea\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u30d9\u30ea\u30fc\u985e\u3001\u30ca\u30c3\u30c4\uff09<\/td><\/tr><tr><td><strong>ATP2B1<\/strong><\/td><td>\u30ab\u30eb\u30b7\u30a6\u30e0\u8f38\u9001\u306e\u8abf\u6574\u304c\u5fc5\u8981<\/td><td>\u30ab\u30eb\u30b7\u30a6\u30e0\u30fb\u30ab\u30ea\u30a6\u30e0\u304c\u591a\u3044\u98df\u54c1\uff08\u4e73\u88fd\u54c1\u3001\u8449\u7269\u91ce\u83dc\uff09<\/td><\/tr><tr><td><strong>NPPA<\/strong><\/td><td>\u30ca\u30c8\u30ea\u30a6\u30e0\u6392\u6cc4\u80fd\u529b\u306e\u4f4e\u4e0b<\/td><td>\u5869\u5206\u5236\u9650\u3068\u9069\u5ea6\u306a\u6c34\u5206\u88dc\u7d66<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u7269\u7406\u7684\u6d3b\u52d5\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9254\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306f\u904b\u52d5\u3078\u306e\u53cd\u5fdc\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u306b\u3001\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u306f\u3001\u9069\u5207\u306a\u904b\u52d5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u5225\u306e\u904b\u52d5\u9069\u5fdc\u6027<\/strong><\/h3>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001ACE\u907a\u4f1d\u5b50\u3084NOS3\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u904b\u52d5\u306b\u3088\u308b\u8840\u5727\u6539\u5584\u52b9\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u904b\u52d5<\/strong><\/td><\/tr><tr><td><strong>ACE\uff08I\/D\u591a\u578b\uff09<\/strong><\/td><td>I\u578b\u306f\u6301\u4e45\u529b\u5411\u4e0a\u3001D\u578b\u306f\u7b4b\u529b\u5411\u4e0a\u306b\u95a2\u9023<\/td><td>\u6301\u4e45\u7cfb\u904b\u52d5\uff08\u30b8\u30e7\u30ae\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\uff09<\/td><\/tr><tr><td><strong>NOS3\uff08\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528\uff09<\/strong><\/td><td>\u8840\u7ba1\u306e\u62e1\u5f35\u80fd\u529b\u306b\u5f71\u97ff<\/td><td>HIIT\u3084\u8efd\u3044\u6709\u9178\u7d20\u904b\u52d5<\/td><\/tr><tr><td><strong>AGT<\/strong><\/td><td>\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u304c\u9ad8\u3044<\/td><td>\u30e8\u30ac\u3084\u30b9\u30c8\u30ec\u30c3\u30c1\u3092\u542b\u3080\u904b\u52d5<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u904b\u52d5\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u904b\u52d5\u306f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u6709\u9178\u7d20\u904b\u52d5\u3092\u5b9a\u671f\u7684\u306b\u884c\u3046\u3053\u3068\u3067\u3001\u8840\u5727\u3092\u4e0a\u6607\u3055\u305b\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u6291\u5236\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg\" alt=\"\" class=\"wp-image-9460\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u8840\u5727\u4e0a\u6607\u306e\u5927\u304d\u306a\u8981\u56e0\u3067\u3042\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8010\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>COMT\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h3>\n\n\n\n<p>COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u3001\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\uff09\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>COMT\u907a\u4f1d\u5b50\u578b<\/strong><\/td><td><strong>\u7279\u5fb4<\/strong><\/td><td><strong>\u63a8\u5968\u3055\u308c\u308b\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u6cd5<\/strong><\/td><\/tr><tr><td><strong>Val\/Val<\/strong><\/td><td>\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u9ad8\u3044<\/td><td>\u6709\u9178\u7d20\u904b\u52d5\u3084\u7791\u60f3<\/td><\/tr><tr><td><strong>Met\/Met<\/strong><\/td><td>\u30b9\u30c8\u30ec\u30b9\u306b\u654f\u611f<\/td><td>\u30e8\u30ac\u3001\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9<\/td><\/tr><tr><td><strong>Val\/Met<\/strong><\/td><td>\u4e2d\u9593\u7684\u306a\u7279\u6027<\/td><td>\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u751f\u6d3b\u7fd2\u6163<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30b9\u30c8\u30ec\u30b9\u8efd\u6e1b\u306b\u5f79\u7acb\u3064\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u7791\u60f3<\/strong>\uff08\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3092\u4f4e\u6e1b\uff09<\/li>\n\n\n\n<li><strong>\u6df1\u547c\u5438\u6cd5<\/strong>\uff08\u81ea\u5f8b\u795e\u7d4c\u3092\u6574\u3048\u308b\uff09<\/li>\n\n\n\n<li><strong>\u30ea\u30ba\u30e0\u904b\u52d5<\/strong>\uff08\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3084\u30c0\u30f3\u30b9\u306a\u3069\uff09<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u9ad8\u8840\u5727\u6cbb\u7642\u306e\u672a\u6765<\/strong><\/h2>\n\n\n\n<p>CRISPR-Cas9\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u9ad8\u8840\u5727\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3092\u76f4\u63a5\u4fee\u6b63\u3059\u308b\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u306e\u53ef\u80fd\u6027<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AGT\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u6574\u3057\u3001\u904e\u5270\u306a\u8840\u5727\u4e0a\u6607\u3092\u9632\u3050<\/strong><\/li>\n\n\n\n<li><strong>ACE\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u4fee\u6b63\u3057\u3001\u8840\u7ba1\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b<\/strong><\/li>\n\n\n\n<li><strong>ATP2B1\u907a\u4f1d\u5b50\u306e\u8abf\u6574\u306b\u3088\u308a\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30d0\u30e9\u30f3\u30b9\u3092\u6700\u9069\u5316<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u502b\u7406\u7684\u8ab2\u984c\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u7de8\u96c6\u304c\u4eba\u9593\u306e\u5065\u5eb7\u306b\u4e0e\u3048\u308b\u9577\u671f\u7684\u5f71\u97ff\u306e\u8a55\u4fa1\u304c\u5fc5\u8981<\/li>\n\n\n\n<li>\u533b\u7642\u502b\u7406\u3068\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u4fdd\u8b77\u306e\u91cd\u8981\u6027<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u5b9f\u7528\u5316\u306b\u5411\u3051\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u9032\u884c<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u6700\u65b0\u306e\u7814\u7a76\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u3068\u8840\u5727\u306e\u95a2\u4fc2\u304c\u307e\u3059\u307e\u3059\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u7814\u7a76\u304c\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41588-019-0355-3\"><strong>Large-scale GWAS study identifies new hypertension-associated loci<\/strong><\/a><\/li>\n\n\n\n<li><strong>The role of epigenetics in hypertension<\/strong><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-021-21048-5\"><strong>CRISPR-based genome editing for hypertension treatment<\/strong><\/a><\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u500b\u5225\u5316\u533b\u7642\u304c\u767a\u5c55\u3057\u3001\u9ad8\u8840\u5727\u306e\u4e88\u9632\u3084\u6cbb\u7642\u304c\u3088\u308a\u52b9\u679c\u7684\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/27532021_m-1024x768.jpg\" alt=\"\u4fdd\u80b2\u5712\u3067\u4ef2\u826f\u304f\u904a\u3076\u5712\u5150\u306e\u5f8c\u308d\u59ff\" class=\"wp-image-9807\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27532021_m-1024x768.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27532021_m-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27532021_m-768x576.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27532021_m-1536x1152.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27532021_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9ad8\u8840\u5727\u306e\u767a\u75c7\u306f\u3001\u907a\u4f1d\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u74b0\u5883\u8981\u56e0\u3068\u3082\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u5834\u5408\u3067\u3082\u3001\u751f\u6d3b\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u98df\u4e8b\u3068\u907a\u4f1d\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u7684\u306b\u5869\u5206\u611f\u53d7\u6027\u304c\u9ad8\u3044\u4eba\u306f\u3001\u5869\u5206\u6442\u53d6\u91cf\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u8840\u5727\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001AGT\u907a\u4f1d\u5b50\u3084ACE\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u6e1b\u5869\u3092\u610f\u8b58\u3057\u305f\u98df\u4e8b\u3092\u53d6\u308b\u3053\u3068\u3067\u3001\u9ad8\u8840\u5727\u3092\u4e88\u9632\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5869\u5206\u5236\u9650\u304c\u6709\u52b9\u306a\u907a\u4f1d\u5b50<\/strong>: ACE, AGT<\/li>\n\n\n\n<li><strong>\u30ab\u30ea\u30a6\u30e0\u6442\u53d6\u304c\u6709\u52b9\u306a\u907a\u4f1d\u5b50<\/strong>: ATP2B1, WNK1<\/li>\n<\/ul>\n\n\n\n<p>\u307e\u305f\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\uff08\u7dd1\u8336\u3001\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u3001\u8d64\u30ef\u30a4\u30f3\u306a\u3069\uff09\u306f\u3001\u8840\u7ba1\u3092\u4fdd\u8b77\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u305f\u3081\u3001\u907a\u4f1d\u7684\u306b\u8840\u5727\u304c\u9ad8\u304f\u306a\u308a\u3084\u3059\u3044\u4eba\u306b\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u904b\u52d5\u3068\u907a\u4f1d\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u3001\u904b\u52d5\u306e\u52b9\u679c\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001ACE\u907a\u4f1d\u5b50\u306eD\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u7b4b\u30c8\u30ec\uff09\u306b\u3088\u308b\u8840\u5727\u6539\u5584\u52b9\u679c\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001I\u578b\u3092\u6301\u3064\u4eba\u306f\u6709\u9178\u7d20\u904b\u52d5\uff08\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3084\u30b8\u30e7\u30ae\u30f3\u30b0\uff09\u304c\u3088\u308a\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6301\u4e45\u7cfb\u904b\u52d5\u304c\u6709\u52b9\u306a\u907a\u4f1d\u5b50<\/strong>: ACE I\u578b, NOS3<\/li>\n\n\n\n<li><strong>\u7b4b\u30c8\u30ec\u304c\u6709\u52b9\u306a\u907a\u4f1d\u5b50<\/strong>: ACE D\u578b, ACTN3<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u9069\u5207\u306a\u904b\u52d5\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u3001\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u767a\u5c55\u3068\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/1490661_m-1024x683.jpg\" alt=\"\u533b\u8005\u3068\u89aa\u5b502\" class=\"wp-image-8696\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490661_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490661_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490661_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490661_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490661_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u533b\u7642\uff08\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\uff09\u304c\u767a\u5c55\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u30b5\u30fc\u30d3\u30b9\u306e\u9032\u5316<\/strong><\/h3>\n\n\n\n<p>\u73fe\u5728\u3001\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u30ad\u30c3\u30c8\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u81ea\u5b85\u3067\u7c21\u5358\u306b\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u4ee3\u8868\u7684\u306a\u691c\u67fb\u30b5\u30fc\u30d3\u30b9\u306b\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>23andMe<\/strong>\uff08\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u3092\u542b\u3080\u5065\u5eb7\u30ea\u30b9\u30af\u89e3\u6790\uff09<\/li>\n\n\n\n<li><strong>MyHeritage DNA<\/strong>\uff08\u5bb6\u7cfb\u60c5\u5831\u3068\u5065\u5eb7\u30ea\u30b9\u30af\u306e\u5206\u6790\uff09<\/li>\n\n\n\n<li><strong>GeneLife<\/strong>\uff08\u65e5\u672c\u4eba\u5411\u3051\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u30b5\u30fc\u30d3\u30b9\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5c06\u6765\u306e\u5065\u5eb7\u7ba1\u7406\u306b\u5f79\u7acb\u3066\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u500b\u5225\u5316\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u9069\u5207\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001CYP2D6\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u3001\u7279\u5b9a\u306e\u964d\u5727\u5264\u304c\u52b9\u679c\u3092\u793a\u3057\u306b\u304f\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u6cbb\u7642\u3078\u306e\u5f71\u97ff<\/strong><\/td><td><strong>\u9069\u3057\u305f\u964d\u5727\u5264<\/strong><\/td><\/tr><tr><td><strong>ACE<\/strong><\/td><td>RAS\u7cfb\u306e\u5f71\u97ff<\/td><td>ACE\u963b\u5bb3\u85ac<\/td><\/tr><tr><td><strong>CYP2D6<\/strong><\/td><td>\u85ac\u7269\u4ee3\u8b1d\u306e\u9055\u3044<\/td><td>\u03b2\u906e\u65ad\u85ac<\/td><\/tr><tr><td><strong>NPPA<\/strong><\/td><td>\u30ca\u30c8\u30ea\u30a6\u30e0\u6392\u6cc4\u80fd\u529b<\/td><td>\u5229\u5c3f\u5264<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u9069\u5207\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>14. \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u751f\u6d3b\u7fd2\u6163<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-1024x683.jpg\" alt=\"\u30e9\u30f3\u30cb\u30f3\u30b0\u30fb\u30b8\u30e7\u30ae\u30f3\u30b0\u30fb\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3059\u308b\u7537\u5973\" class=\"wp-image-9541\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u306f\u3001DNA\u914d\u5217\u81ea\u4f53\u306f\u5909\u5316\u3055\u305b\u305a\u306b\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u4ed5\u7d44\u307f\u306e\u3053\u3068\u3092\u6307\u3057\u307e\u3059\u3002\u74b0\u5883\u8981\u56e0\uff08\u98df\u4e8b\u30fb\u904b\u52d5\u30fb\u30b9\u30c8\u30ec\u30b9\uff09\u306b\u3088\u3063\u3066\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u304c\u8d77\u3053\u308a\u3001\u8840\u5727\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>DNA\u30e1\u30c1\u30eb\u5316\u3068\u8840\u5727<\/strong><\/h3>\n\n\n\n<p>DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u4ee3\u8868\u7684\u306a\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u6a5f\u69cb\u3067\u3059\u3002\u9ad8\u8840\u5727\u60a3\u8005\u3067\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AGT\u907a\u4f1d\u5b50\u306e\u904e\u5270\u30e1\u30c1\u30eb\u5316<\/strong> \u2192 \u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\u7523\u751f\u306e\u4f4e\u4e0b<\/li>\n\n\n\n<li><strong>ACE\u907a\u4f1d\u5b50\u306e\u4f4e\u30e1\u30c1\u30eb\u5316<\/strong> \u2192 \u8840\u5727\u4e0a\u6607\u306e\u30ea\u30b9\u30af\u5897\u5927<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3068\u8840\u5727\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3082\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5236\u5fa1\u306e\u4e00\u3064\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u30b9\u30c8\u30ec\u30b9\u3084\u4e0d\u898f\u5247\u306a\u751f\u6d3b\u7fd2\u6163\u304c\u30d2\u30b9\u30c8\u30f3\u306e\u5316\u5b66\u4fee\u98fe\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8840\u5727\u3092\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u751f\u6d3b\u7fd2\u6163\u306b\u3088\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u751f\u6d3b\u7fd2\u6163<\/strong><\/td><td><strong>\u5f71\u97ff\u3059\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u6a5f\u69cb<\/strong><\/td><td><strong>\u671f\u5f85\u3055\u308c\u308b\u52b9\u679c<\/strong><\/td><\/tr><tr><td><strong>\u91ce\u83dc\u30fb\u679c\u7269\u306e\u6442\u53d6<\/strong><\/td><td>DNA\u30e1\u30c1\u30eb\u5316\u306e\u6539\u5584<\/td><td>\u8840\u5727\u306e\u5b89\u5b9a\u5316<\/td><\/tr><tr><td><strong>\u9069\u5ea6\u306a\u904b\u52d5<\/strong><\/td><td>\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u306e\u8abf\u6574<\/td><td>\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528\u306e\u5f37\u5316<\/td><\/tr><tr><td><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong><\/td><td>miRNA\u306e\u767a\u73fe\u5236\u5fa1<\/td><td>\u81ea\u5f8b\u795e\u7d4c\u306e\u5b89\u5b9a<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u751f\u6d3b\u7fd2\u6163\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u826f\u597d\u306a\u72b6\u614b\u306b\u4fdd\u3064\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>15. \u6700\u65b0\u306e\u7814\u7a76\u52d5\u5411\u3068\u81e8\u5e8a\u5fdc\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30661311_m-1024x585.jpg\" alt=\"\u8a55\u5224\u306e\u533b\u8005\" class=\"wp-image-8392\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30661311_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30661311_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30661311_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30661311_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30661311_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u9ad8\u8840\u5727\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u306b\u5411\u3051\u305f\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u751f\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>AI\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u89e3\u6790<\/strong><\/h3>\n\n\n\n<p>\u4eba\u5de5\u77e5\u80fd\uff08AI\uff09\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u3088\u308a\u3001\u3053\u308c\u307e\u3067\u306b\u306a\u3044\u7cbe\u5ea6\u3067\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u4e88\u6e2c\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u30e2\u30c7\u30eb\u306b\u3088\u308b\u907a\u4f1d\u5b50\u00d7\u74b0\u5883\u30ea\u30b9\u30af\u306e\u89e3\u6790<\/strong><\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316\u6cbb\u7642\u8a08\u753b\u306e\u81ea\u52d5\u751f\u6210<\/strong><\/li>\n<\/ul>\n\n\n\n<p>AI\u306e\u6d3b\u7528\u306b\u3088\u308a\u3001\u3088\u308a\u9ad8\u5ea6\u306a\u500b\u5225\u5316\u533b\u7642\u304c\u5b9f\u73fe\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306e\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<p>CRISPR-Cas9\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308a\u3001\u9ad8\u8840\u5727\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3092\u4fee\u6b63\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AGT\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u8abf\u7bc0<\/strong> \u2192 \u8840\u5727\u306e\u6b63\u5e38\u5316<\/li>\n\n\n\n<li><strong>ATP2B1\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u5f37\u5316<\/strong> \u2192 \u30ab\u30eb\u30b7\u30a6\u30e0\u30d0\u30e9\u30f3\u30b9\u306e\u6539\u5584<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u304c\u5b9f\u7528\u5316\u3055\u308c\u308c\u3070\u3001\u9ad8\u8840\u5727\u306e\u6839\u672c\u7684\u306a\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>16. \u907a\u4f1d\u5b50\u591a\u578b\u3068\u964d\u5727\u85ac\u306e\u9078\u629e<\/strong><\/h2>\n\n\n\n<p>\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u3067\u306f\u3001\u964d\u5727\u85ac\u3092\u7528\u3044\u305f\u85ac\u7269\u7642\u6cd5\u304c\u4e00\u822c\u7684\u3067\u3059\u304c\u3001\u907a\u4f1d\u5b50\u591a\u578b\u306b\u3088\u3063\u3066\u85ac\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306b\u500b\u4eba\u5dee\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u591a\u578b\u3068\u306f\uff1f<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u591a\u578b\uff08SNP: Single Nucleotide Polymorphism\uff09\u306f\u3001DNA\u306e\u7279\u5b9a\u306e\u5869\u57fa\u304c\u500b\u4eba\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u5909\u7570\u306e\u3053\u3068\u3092\u6307\u3057\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u304c\u85ac\u7269\u306e\u52b9\u679c\u3084\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u964d\u5727\u85ac\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u9023<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u964d\u5727\u85ac\u306e\u7a2e\u985e<\/strong><\/td><td><strong>\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u907a\u4f1d\u5b50\u591a\u578b\u306e\u5f71\u97ff<\/strong><\/td><\/tr><tr><td><strong>ACE\u963b\u5bb3\u85ac<\/strong><\/td><td>ACE<\/td><td>ACE I\/D\u591a\u578b\u304c\u85ac\u306e\u52b9\u679c\u306b\u5f71\u97ff<\/td><\/tr><tr><td><strong>ARB\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\uff09<\/strong><\/td><td>AGTR1<\/td><td>AGTR1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u52b9\u679c\u304c\u7570\u306a\u308b<\/td><\/tr><tr><td><strong>\u03b2\u906e\u65ad\u85ac<\/strong><\/td><td>ADRB1, CYP2D6<\/td><td>CYP2D6\u306e\u907a\u4f1d\u7684\u5909\u7570\u306b\u3088\u308a\u4ee3\u8b1d\u901f\u5ea6\u304c\u5909\u5316<\/td><\/tr><tr><td><strong>Ca\u62ee\u6297\u85ac<\/strong><\/td><td>ATP2B1<\/td><td>ATP2B1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u85ac\u7269\u53cd\u5fdc\u306b\u5f71\u97ff<\/td><\/tr><tr><td><strong>\u5229\u5c3f\u5264<\/strong><\/td><td>NPPA, WNK1<\/td><td>\u30ca\u30c8\u30ea\u30a6\u30e0\u6392\u6cc4\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u305f\u3068\u3048\u3070\u3001ACE I\/D\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001ACE\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u304c\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001ARB\u3084Ca\u62ee\u6297\u85ac\u3078\u306e\u5909\u66f4\u304c\u6709\u52b9\u306a\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u85ac\u7269\u4ee3\u8b1d\u9175\u7d20\u3068\u964d\u5727\u85ac\u306e\u52b9\u679c<\/strong><\/h3>\n\n\n\n<p>CYP2D6\u907a\u4f1d\u5b50\u306f\u3001\u03b2\u906e\u65ad\u85ac\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u85ac\u304c\u52b9\u304d\u3059\u304e\u305f\u308a\u3001\u9006\u306b\u52b9\u679c\u304c\u5f31\u304f\u306a\u3063\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3088\u308a\u9069\u3057\u305f\u85ac\u3092\u9078\u629e\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>17. \u8178\u5185\u7d30\u83cc\u3068\u8840\u5727\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8852\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/2355241_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u8178\u5185\u7d30\u83cc\u304c\u8840\u5727\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u306f\u3001\u7279\u5b9a\u306e\u4ee3\u8b1d\u7523\u7269\u3092\u7523\u751f\u3057\u3001\u8840\u7ba1\u6a5f\u80fd\u3084\u708e\u75c7\u53cd\u5fdc\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8178\u5185\u7d30\u83cc\u304c\u8840\u5727\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09\u306e\u7523\u751f<\/strong> \u2192 \u8840\u7ba1\u3092\u62e1\u5f35\u3057\u3001\u8840\u5727\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/li>\n\n\n\n<li><strong>\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u6291\u5236<\/strong> \u2192 \u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b<\/li>\n\n\n\n<li><strong>\u5869\u5206\u611f\u53d7\u6027\u306e\u8abf\u6574<\/strong> \u2192 \u30ca\u30c8\u30ea\u30a6\u30e0\u6392\u6cc4\u306b\u95a2\u4e0e<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9ad8\u8840\u5727\u60a3\u8005\u306e\u8178\u5185\u7d30\u83cc\u306e\u7279\u5fb4<\/strong><\/h3>\n\n\n\n<p>\u9ad8\u8840\u5727\u306e\u4eba\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u5584\u7389\u83cc\uff08Bifidobacterium\u3001Lactobacillus\uff09\u304c\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u708e\u75c7\u3092\u4fc3\u9032\u3059\u308b\u8178\u5185\u7d30\u83cc\uff08Proteobacteria\u306a\u3069\uff09\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8178\u5185\u7d30\u83cc\u3092\u6539\u5584\u3059\u308b\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u6442\u53d6<\/strong>\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u767a\u9175\u98df\u54c1\uff09<\/li>\n\n\n\n<li><strong>\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u6442\u53d6<\/strong>\uff08\u98df\u7269\u7e4a\u7dad\u3001\u30aa\u30ea\u30b4\u7cd6\uff09<\/li>\n\n\n\n<li><strong>\u98df\u751f\u6d3b\u306e\u6539\u5584<\/strong>\uff08\u52a0\u5de5\u98df\u54c1\u3092\u6e1b\u3089\u3057\u3001\u91ce\u83dc\u4e2d\u5fc3\u306e\u98df\u4e8b\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u3001\u8840\u5727\u306e\u7ba1\u7406\u306b\u3082\u826f\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>18. \u907a\u4f1d\u5b50\u30c9\u30ea\u30d5\u30c8\u3068\u8840\u5727\u306e\u9032\u5316\u7684\u80cc\u666f<\/strong><\/h2>\n\n\n\n<p>\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u306f\u3001\u9032\u5316\u306e\u904e\u7a0b\u3067\u3069\u306e\u3088\u3046\u306b\u5f62\u6210\u3055\u308c\u305f\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u907a\u4f1d\u5b50\u30c9\u30ea\u30d5\u30c8\u3084\u81ea\u7136\u9078\u629e\u306e\u5f71\u97ff\u306b\u3088\u308a\u3001\u9ad8\u8840\u5727\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u304c\u96c6\u56e3\u3054\u3068\u306b\u7570\u306a\u308b\u5206\u5e03\u3092\u793a\u3059\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u300c\u7bc0\u7d04\u907a\u4f1d\u5b50\u4eee\u8aac\u300d\u3068\u9ad8\u8840\u5727<\/strong><\/h3>\n\n\n\n<p>\u300c\u7bc0\u7d04\u907a\u4f1d\u5b50\u4eee\u8aac\u300d\u3068\u306f\u3001\u4eba\u985e\u306e\u7956\u5148\u304c\u98e2\u9913\u306b\u9069\u5fdc\u3059\u308b\u305f\u3081\u306b\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u52b9\u7387\u7684\u306b\u4fdd\u6301\u3059\u308b\u907a\u4f1d\u5b50\u3092\u9032\u5316\u3055\u305b\u305f\u3068\u3044\u3046\u8aac\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u73fe\u4ee3\u793e\u4f1a\u3067\u306f\u904e\u5270\u306a\u5869\u5206\u3084\u30ab\u30ed\u30ea\u30fc\u6442\u53d6\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u304c\u9ad8\u8840\u5727\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u6c11\u65cf\u306b\u3088\u308b\u907a\u4f1d\u7684\u591a\u69d8\u6027<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a2\u30d5\u30ea\u30ab\u7cfb<\/strong>\uff1a\u5869\u5206\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u3092\u4fdd\u6301\u3057\u3084\u3059\u3044\uff08AGT\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\uff09<\/li>\n\n\n\n<li><strong>\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb<\/strong>\uff1aACE\u907a\u4f1d\u5b50\u306e\u591a\u578b\u304c\u964d\u5727\u85ac\u306e\u52b9\u679c\u306b\u5f71\u97ff<\/li>\n\n\n\n<li><strong>\u30a2\u30b8\u30a2\u7cfb<\/strong>\uff1aATP2B1\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u304c\u5927\u304d\u304f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u4ee3\u8b1d\u3068\u95a2\u9023<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u306e\u591a\u69d8\u6027\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u53ef\u80fd\u6027\u304c\u5e83\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>19. \u907a\u4f1d\u5b50\u3068\u9ad8\u8840\u5727\u5408\u4f75\u75c7<\/strong><\/h2>\n\n\n\n<p>\u9ad8\u8840\u5727\u306f\u3001\u5358\u306a\u308b\u8840\u5727\u4e0a\u6607\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u3055\u307e\u3056\u307e\u306a\u5408\u4f75\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3059\u308b\u9ad8\u8840\u5727\u306e\u5408\u4f75\u75c7\u306b\u306f\u3001\u5fc3\u75be\u60a3\u3084\u814e\u75be\u60a3\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u75be\u60a3<\/strong><\/td><td><strong>\u95a2\u9023\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><\/tr><tr><td><strong>\u8133\u5352\u4e2d<\/strong><\/td><td>NOS3, MTHFR<\/td><td>\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u306e\u4f4e\u4e0b<\/td><\/tr><tr><td><strong>\u5fc3\u7b4b\u6897\u585e<\/strong><\/td><td>LPA, PCSK9<\/td><td>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u306e\u7570\u5e38<\/td><\/tr><tr><td><strong>\u6162\u6027\u814e\u81d3\u75c5<\/strong><\/td><td>UMOD, APOL1<\/td><td>\u814e\u6a5f\u80fd\u306e\u4f4e\u4e0b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u5834\u5408\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u5408\u4f75\u75c7\u306e\u4e88\u9632\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u30ea\u30b9\u30af\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u5834\u5408\u306f\u65e9\u671f\u691c\u67fb\u3092\u63a8\u5968<\/strong><\/li>\n\n\n\n<li><strong>\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3092\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u57fa\u3065\u3044\u3066\u6700\u9069\u5316<\/strong><\/li>\n\n\n\n<li><strong>\u9ad8\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u3092\u6301\u3064\u5834\u5408\u3001\u7a4d\u6975\u7684\u306a\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u9ad8\u8840\u5727\u3060\u3051\u3067\u306a\u304f\u95a2\u9023\u3059\u308b\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>20. \u907a\u4f1d\u5b50\u7642\u6cd5\u306e\u672a\u6765<\/strong><\/h2>\n\n\n\n<p>\u73fe\u5728\u3001\u9ad8\u8840\u5727\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u7642\u6cd5\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002CRISPR-Cas9\u306a\u3069\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u3092\u8abf\u6574\u3059\u308b\u8a66\u307f\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AGT\u907a\u4f1d\u5b50\u306e\u8abf\u6574<\/strong> \u2192 \u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\u306e\u904e\u5270\u751f\u6210\u3092\u9632\u3050<\/li>\n\n\n\n<li><strong>ATP2B1\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316<\/strong> \u2192 \u8840\u7ba1\u5e73\u6ed1\u7b4b\u306e\u8abf\u6574\u3092\u5f37\u5316<\/li>\n\n\n\n<li><strong>PCSK9\u306e\u5236\u5fa1<\/strong> \u2192 \u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u4e88\u9632<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u304c\u5b9f\u7528\u5316\u3055\u308c\u308c\u3070\u3001\u9ad8\u8840\u5727\u306e\u6839\u672c\u7684\u306a\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>21. \u907a\u4f1d\u5b50\u3068\u9ad8\u8840\u5727\u306b\u95a2\u9023\u3059\u308b\u65b0\u8208\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u65b0\u305f\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u7279\u5b9a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u30ec\u30d9\u30eb\u3084\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6fc3\u5ea6\u5909\u5316\u3092\u6307\u6a19\u3068\u3057\u3066\u304a\u308a\u3001\u65e9\u671f\u8a3a\u65ad\u3084\u500b\u5225\u5316\u533b\u7642\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9ad8\u8840\u5727\u306e\u65b0\u8208\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u4e00\u89a7<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc<\/strong><\/td><td><strong>\u95a2\u9023\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><\/tr><tr><td><strong>miR-143\/145<\/strong><\/td><td>ATP2B1<\/td><td>\u8840\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\u306e\u8abf\u7bc0\u3001\u8840\u5727\u306e\u7dad\u6301<\/td><\/tr><tr><td><strong>NT-proBNP<\/strong><\/td><td>NPPA<\/td><td>\u5fc3\u4e0d\u5168\u3084\u9ad8\u8840\u5727\u306e\u6307\u6a19<\/td><\/tr><tr><td><strong>Angiotensinogen (AGT)<\/strong><\/td><td>AGT<\/td><td>\u30ec\u30cb\u30f3-\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u306e\u6d3b\u6027\u8abf\u6574<\/td><\/tr><tr><td><strong>Circulating free DNA (cfDNA)<\/strong><\/td><td>&#8211;<\/td><td>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u306e\u6307\u6a19<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u6d3b\u7528\u3057\u305f\u8a3a\u65ad\u306e\u53ef\u80fd\u6027<\/strong><\/h3>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001miR-143\/145\u306e\u767a\u73fe\u4f4e\u4e0b\u306f\u8840\u5727\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u65e9\u671f\u306e\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001NT-proBNP\u306e\u6e2c\u5b9a\u306f\u3001\u8840\u5727\u306e\u7570\u5e38\u304c\u5fc3\u8840\u7ba1\u7cfb\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u6709\u7528\u306a\u6307\u6a19\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>22. \u907a\u4f1d\u5b50\u3068\u9ad8\u8840\u5727\u306b\u304a\u3051\u308b\u6027\u5dee<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u3068\u9ad8\u8840\u5727\u306e\u95a2\u4fc2\u306f\u3001\u6027\u5225\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u30db\u30eb\u30e2\u30f3\u306e\u9055\u3044\u3084\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u7537\u5973\u3067\u7570\u306a\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u6027\u5225\u306b\u3088\u308b\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u306e\u9055\u3044<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u8981\u56e0<\/strong><\/td><td><strong>\u7537\u6027<\/strong><\/td><td><strong>\u5973\u6027<\/strong><\/td><\/tr><tr><td><strong>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u5f71\u97ff<\/strong><\/td><td>\u4f4e\u3044<\/td><td>\u9ad8\u3044\uff08\u8840\u7ba1\u62e1\u5f35\u4f5c\u7528\uff09<\/td><\/tr><tr><td><strong>ACE\u907a\u4f1d\u5b50\u306e\u767a\u73fe<\/strong><\/td><td>\u9ad8\u3044<\/td><td>\u4f4e\u3044<\/td><\/tr><tr><td><strong>\u8840\u5727\u4e0a\u6607\u306e\u5e74\u9f62\u50be\u5411<\/strong><\/td><td>40\u4ee3\u4ee5\u964d<\/td><td>\u9589\u7d4c\u5f8c\u306b\u6025\u5897<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306f\u8840\u7ba1\u3092\u62e1\u5f35\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u305f\u3081\u3001\u9589\u7d4c\u524d\u306e\u5973\u6027\u306f\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u9589\u7d4c\u5f8c\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u6e1b\u5c11\u306b\u3088\u308a\u8840\u5727\u304c\u4e0a\u6607\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5973\u6027\u306e\u9ad8\u8840\u5727\u7ba1\u7406\u306b\u306f\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u8003\u616e\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u9ad8\u8840\u5727\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u767a\u75c7\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u8840\u5727\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3084\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u7814\u7a76\u304c\u9032\u307f\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u53ef\u80fd\u6027\u304c\u5e83\u304c\u308b\u4e2d\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3084\u9069\u5207\u306a\u85ac\u7269\u7642\u6cd5\u306e\u9078\u629e\u304c\u91cd\u8981\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u8178\u5185\u7d30\u83cc\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u7814\u7a76\u3082\u9032\u5c55\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u9ad8\u8840\u5727\u7ba1\u7406\u306b\u304a\u3044\u3066\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> 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[&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":10033,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[52,40,41,59,36,49,34,45,55],"class_list":["post-10032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-basicknowledge","tag-dna-test","tag-privacy","tag-personalized-medicine","tag-59","tag-gene-testing","tag-gene-analysis","tag-genetic-identification","tag-genetics","tag-genetic-diseases"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10032","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=10032"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10032\/revisions"}],"predecessor-version":[{"id":10054,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10032\/revisions\/10054"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/10033"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=10032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=10032"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=10032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}