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\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u8a8d\u77e5\u75c7\u3068\u907a\u4f1d\u7684\u8981\u56e0\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n
APOE\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7<\/strong><\/h5>\n\n\n\n

\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\uff08AD\uff09\u306f\u3001\u8a8d\u77e5\u75c7\u306e\u4e2d\u3067\u3082\u6700\u3082\u4e00\u822c\u7684\u306a\u30bf\u30a4\u30d7\u3067\u3042\u308a\u3001\u305d\u306e\u30ea\u30b9\u30af\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066APOE\uff08\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30afE\uff09\u907a\u4f1d\u5b50<\/strong>\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306bAPOE\u306e\u03b54\u30a2\u30ec\u30eb\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u30922\u500d\u304b\u308912\u500d\u306b\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002APOE\u03b54\u30922\u3064\u6301\u3064\u5834\u5408\u3001\u30ea\u30b9\u30af\u306f\u3055\u3089\u306b\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aNational Institute on Aging – APOE and Alzheimer\u2019s Disease<\/a><\/p>\n\n\n\n

\u4ed6\u306e\u30ea\u30b9\u30af\u907a\u4f1d\u5b50<\/strong><\/h5>\n\n\n\n

APOE\u4ee5\u5916\u306b\u3082\u3001TREM2\u3084CLU\u3001PICALM\u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u304c\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002TREM2\u306e\u5909\u7570\u306f\u3001\u8133\u5185\u306e\u708e\u75c7\u53cd\u5fdc\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u308c\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u9032\u884c\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001CLU\u3084PICALM\u306f\u3001\u8133\u5185\u3067\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u3084\u9664\u53bb\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u305e\u308c\u306e\u6a5f\u80fd\u7570\u5e38\u304c\u75c5\u6c17\u306e\u767a\u75c7\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aNature Genetics – Common variants at ABCA7, MS4A, and EPHA1 are associated with Alzheimer\u2019s disease<\/a><\/p>\n\n\n\n

\n <\/p>\n
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\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

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\u8fd1\u5e74\u3001\u591a\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08Polygenic Risk Score, PRS\uff09\u304c\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u6d3b\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002PRS\u306f\u8907\u6570\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306e\u5f71\u97ff\u3092\u7d71\u5408\u7684\u306b\u8a55\u4fa1\u3059\u308b\u65b9\u6cd5\u3067\u3001\u500b\u4eba\u306e\u30ea\u30b9\u30af\u3092\u3088\u308a\u6b63\u78ba\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u7279\u306b\u3001APOE\u03b54\u3092\u6301\u305f\u306a\u3044\u4eba\u3067\u3082\u3001\u4ed6\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u30b1\u30fc\u30b9\u304c\u3042\u308b\u305f\u3081\u3001\u5305\u62ec\u7684\u306a\u89e3\u6790\u304c\u91cd\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u306e\u5fdc\u7528<\/strong><\/h5>\n\n\n\n

\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08NGS\uff09\u6280\u8853\u306f\u3001\u5168\u30b2\u30ce\u30e0\u3092\u8fc5\u901f\u304b\u3064\u4f4e\u30b3\u30b9\u30c8\u3067\u89e3\u6790\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u6280\u8853\u306b\u3088\u308a\u3001\u5f93\u6765\u306f\u767a\u898b\u304c\u96e3\u3057\u304b\u3063\u305f\u5e0c\u5c11\u306a\u907a\u4f1d\u5b50\u5909\u7570\u3082\u7279\u5b9a\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u65b0\u305f\u306a\u5149\u304c\u5f53\u3066\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001SORL1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
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\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

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\u8a8d\u77e5\u75c7\u4e88\u9632\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u6d3b\u7528<\/strong><\/h4>\n\n\n\n
\u65e9\u671f\u8a3a\u65ad\u3068\u500b\u5225\u5316\u533b\u7642<\/strong><\/h5>\n\n\n\n

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\n <\/p>\n
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\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h4>\n\n\n\n
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\u907a\u4f1d\u5b50\u3068\u904b\u52d5<\/strong><\/h5>\n\n\n\n

\u7814\u7a76\u306b\u3088\u308c\u3070\u3001\u5b9a\u671f\u7684\u306a\u904b\u52d5\u306fAPOE\u03b54\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u3063\u3066\u3082\u8a8d\u77e5\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u904b\u52d5\u304c\u8133\u5185\u306e\u8840\u6d41\u3092\u6539\u5584\u3057\u3001\u795e\u7d4c\u6210\u9577\u56e0\u5b50\uff08BDNF\uff09\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u90e8\u5206\u7684\u306b\u7de9\u548c\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aJournal of Alzheimer\u2019s Disease – Physical Exercise and APOE Genotype<\/a><\/p>\n\n\n\n

\n <\/p>\n
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\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

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\n\n\n\n

\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3068\u8a8d\u77e5\u75c7\u6cbb\u7642\u306e\u53ef\u80fd\u6027<\/strong><\/h4>\n\n\n\n
\"\u8eca\u3044\u3059\u306b\u4e57\u3063\u305f\u9ad8\u9f62\u8005\n\"<\/figure>\n\n\n\n
CRISPR-Cas9\u306b\u3088\u308b\u6cbb\u7642\u6cd5<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3067\u3042\u308bCRISPR-Cas9\u306f\u3001\u8a8d\u77e5\u75c7\u6cbb\u7642\u306e\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u5207\u308a\u958b\u3044\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4e3b\u8981\u306a\u539f\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u84c4\u7a4d\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u9818\u57df\u3092\u7de8\u96c6\u3059\u308b\u7814\u7a76\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002\u3053\u306e\u6280\u8853\u306f\u3001\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u6839\u672c\u7684\u306b\u4fee\u6b63\u3059\u308b\u53ef\u80fd\u6027\u3092\u6301\u3061\u3001\u5c06\u6765\u7684\u306a\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u7de8\u96c6<\/strong><\/h5>\n\n\n\n

CRISPR\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u7279\u5b9a\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u4fee\u98fe\u3092\u64cd\u4f5c\u3059\u308b\u8a66\u307f\u3082\u59cb\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3057\u3001\u75c5\u6c17\u306e\u9032\u884c\u3092\u6291\u5236\u3059\u308b\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u907a\u4f1d\u5b50\u7814\u7a76\u3068\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u8ab2\u984c<\/strong><\/h4>\n\n\n\n
\u30c7\u30fc\u30bf\u306e\u516c\u5e73\u6027\u3068\u591a\u69d8\u6027<\/strong><\/h5>\n\n\n\n

\u73fe\u5728\u3001\u591a\u304f\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u306f\u6b27\u7c73\u306e\u4eba\u53e3\u3092\u4e2d\u5fc3\u306b\u884c\u308f\u308c\u3066\u304a\u308a\u3001\u4ed6\u306e\u4eba\u7a2e\u3084\u5730\u57df\u306b\u304a\u3051\u308b\u30c7\u30fc\u30bf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4e0d\u5747\u8861\u3092\u662f\u6b63\u3057\u3001\u3088\u308a\u591a\u69d8\u306a\u30c7\u30fc\u30bf\u3092\u53ce\u96c6\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u502b\u7406\u7684\u8ab2\u984c<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u969b\u306b\u306f\u3001\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77\u3084\u60c5\u5831\u306e\u9069\u5207\u306a\u5229\u7528\u306b\u95a2\u3059\u308b\u502b\u7406\u7684\u554f\u984c\u304c\u4f34\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u304c\u4fdd\u967a\u3084\u96c7\u7528\u3067\u5dee\u5225\u7684\u306b\u5229\u7528\u3055\u308c\u306a\u3044\u3088\u3046\u3001\u53b3\u683c\u306a\u30eb\u30fc\u30eb\u3068\u6cd5\u7684\u67a0\u7d44\u307f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u7ba1\u7406\u306b\u304a\u3051\u308b\u65b0\u3057\u3044\u7814\u7a76\u52d5\u5411<\/strong><\/h4>\n\n\n\n
\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u7cfb\u306e\u95a2\u4fc2<\/strong><\/h5>\n\n\n\n

\u8fd1\u5e74\u3001\u514d\u75ab\u7cfb\u3068\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u8133\u5185\u306e\u514d\u75ab\u7d30\u80de\u3067\u3042\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6d3b\u52d5\u304c\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u8abf\u6574\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002TREM2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u50cd\u304d\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067\u8133\u5185\u306e\u8001\u5ec3\u7269\u9664\u53bb\u3092\u59a8\u3052\u3001\u7d50\u679c\u7684\u306b\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u84c4\u7a4d\u3092\u52a9\u9577\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u767a\u898b\u306f\u3001\u8a8d\u77e5\u75c7\u306e\u65b0\u3057\u3044\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u514d\u75ab\u7cfb\u3092\u6d3b\u7528\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u8840\u6db2\u691c\u67fb\u3068\u907a\u4f1d\u5b50\u306e\u7d44\u307f\u5408\u308f\u305b<\/strong><\/h5>\n\n\n\n

\u5f93\u6765\u3001\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u306e\u8a55\u4fa1\u306b\u306f\u8133\u30b9\u30ad\u30e3\u30f3\u3084\u8170\u690e\u7a7f\u523a\u3068\u3044\u3063\u305f\u4fb5\u8972\u7684\u306a\u65b9\u6cd5\u304c\u5fc5\u8981\u3067\u3057\u305f\u304c\u3001\u8840\u6db2\u691c\u67fb\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u7c21\u4fbf\u304b\u3064\u6b63\u78ba\u306a\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7279\u5b9a\u306e\u8840\u4e2d\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\uff09\u306e\u6e2c\u5b9a\u3068\u3001APOE\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u8a8d\u77e5\u75c7\u767a\u75c7\u524d\u306e\u5146\u5019\u3092\u7279\u5b9a\u3059\u308b\u7814\u7a76\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002<\/p>\n\n\n\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aThe Lancet Neurology – Blood biomarkers and Alzheimer\u2019s disease<\/a><\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n
\u7761\u7720\u306e\u8cea\u3068\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u5b50\u7814\u7a76\u306f\u3001\u7761\u7720\u3068\u8a8d\u77e5\u75c7\u306e\u95a2\u9023\u6027\u3092\u6df1\u304f\u7406\u89e3\u3059\u308b\u9375\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u306b\u3088\u308c\u3070\u3001CRY1\u3084PER2\u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u304c\u7761\u7720\u306e\u30ea\u30ba\u30e0\u3084\u8cea\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u305d\u308c\u304c\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u306b\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7761\u7720\u4e0d\u8db3\u3084\u8cea\u306e\u60aa\u3044\u7761\u7720\u306f\u3001\u8133\u5185\u3067\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u84c4\u7a4d\u3092\u52a0\u901f\u3055\u305b\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7761\u7720\u969c\u5bb3\u306e\u907a\u4f1d\u7684\u611f\u53d7\u6027<\/strong><\/h5>\n\n\n\n

\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3001\u7761\u7720\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u3044\u4f53\u8cea\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001ADORA2A\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u4e0d\u7720\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u7761\u7720\u7ba1\u7406\u3084\u4e88\u9632\u7b56\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u8a8d\u77e5\u75c7\u4e88\u9632\u306b\u304a\u3051\u308b\u904b\u52d5\u306e\u5f79\u5272\u3068\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h4>\n\n\n\n
\"\u904b\u52d5\u3059\u308b\u9ad8\u9f62\u8005\"<\/figure>\n\n\n\n
\u6709\u9178\u7d20\u904b\u52d5\u3068\u8133\u306e\u5065\u5eb7<\/strong><\/h5>\n\n\n\n

\u6709\u9178\u7d20\u904b\u52d5\u306f\u3001\u8a8d\u77e5\u75c7\u4e88\u9632\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u624b\u6bb5\u3068\u3057\u3066\u5e83\u304f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u52b9\u679c\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5909\u52d5\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002APOE\u03b54\u30ad\u30e3\u30ea\u30a2\u3067\u3042\u3063\u3066\u3082\u3001\u5b9a\u671f\u7684\u306a\u6709\u9178\u7d20\u904b\u52d5\u304c\u8133\u5185\u306e\u8840\u6d41\u3092\u6539\u5584\u3057\u3001\u6d77\u99ac\u306e\u840e\u7e2e\u3092\u9632\u3050\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u904b\u52d5\u3068BDNF\u907a\u4f1d\u5b50<\/strong><\/h5>\n\n\n\n

BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3084\u4fee\u5fa9\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u904b\u52d5\u306b\u3088\u3063\u3066\u305d\u306e\u7523\u751f\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001BDNF\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u3053\u306e\u52b9\u679c\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5834\u5408\u3001\u904b\u52d5\u91cf\u3084\u904b\u52d5\u306e\u7a2e\u985e\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u6804\u990a\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h4>\n\n\n\n
\u5730\u4e2d\u6d77\u5f0f\u98df\u4e8b\u3068APOE\u907a\u4f1d\u5b50<\/strong><\/h5>\n\n\n\n

\u5730\u4e2d\u6d77\u5f0f\u98df\u4e8b\u306f\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u98df\u4e8b\u6cd5\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u52b9\u679c\u306fAPOE\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7814\u7a76\u306b\u3088\u308c\u3070\u3001APOE\u03b54\u3092\u6301\u3064\u4eba\u3005\u3067\u3082\u3001\u5730\u4e2d\u6d77\u5f0f\u98df\u4e8b\u3092\u9577\u671f\u7684\u306b\u5b9f\u8df5\u3059\u308b\u3053\u3068\u3067\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u304c\u7de9\u3084\u304b\u306b\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u98df\u4e8b\u6cd5\u306b\u306f\u3001\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3001\u9b5a\u3001\u30ca\u30c3\u30c4\u3001\u91ce\u83dc\u3068\u3044\u3063\u305f\u98df\u54c1\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u6804\u990a\u7d20\u306e\u4ee3\u8b1d\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50<\/strong><\/h5>\n\n\n\n

\u7279\u5b9a\u306e\u6804\u990a\u7d20\u306e\u4ee3\u8b1d\u80fd\u529b\u3082\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001MTHFR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u8449\u9178\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u5024\u3092\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u306f\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u60c5\u5831\u3092\u57fa\u306b\u8449\u9178\u3084\u30d3\u30bf\u30df\u30f3B12\u306e\u6442\u53d6\u91cf\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u4e88\u9632\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u53ef\u80fd\u6027<\/strong><\/h4>\n\n\n\n
\u907a\u4f1d\u5b50\u6cbb\u7642\u3068CRISPR\u6280\u8853<\/strong><\/h5>\n\n\n\n

CRISPR-Cas9\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306f\u3001\u8a8d\u77e5\u75c7\u6cbb\u7642\u306e\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u5207\u308a\u958b\u3044\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3084\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u6210\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u306e\u7de8\u96c6\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6280\u8853\u306f\u3001\u907a\u4f1d\u5b50\u306e\u6b20\u9665\u3092\u76f4\u63a5\u4fee\u5fa9\u3059\u308b\u3053\u3068\u3067\u3001\u75c5\u6c17\u306e\u9032\u884c\u3092\u6839\u672c\u7684\u306b\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u85ac\u7269\u7642\u6cd5<\/strong><\/h5>\n\n\n\n

\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u85ac\u7269\u7642\u6cd5\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001HDAC\uff08\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\uff09\u963b\u5bb3\u5264\u306f\u3001\u8a8d\u77e5\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5206\u91ce\u306e\u7814\u7a76\u306f\u307e\u3060\u521d\u671f\u6bb5\u968e\u3067\u3059\u304c\u3001\u5c06\u6765\u7684\u306a\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u793e\u4f1a\u7684\u8981\u56e0\u3068\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u306e\u7d71\u5408<\/strong><\/h4>\n\n\n\n
\u8a8d\u77e5\u75c7\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u30ab\u30b9\u30bf\u30de\u30a4\u30ba<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u8a8d\u77e5\u75c7\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u3001\u5730\u57df\u3084\u793e\u4f1a\u5168\u4f53\u3067\u306e\u5c0e\u5165\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001\u500b\u3005\u306e\u30ea\u30b9\u30af\u8981\u56e0\u306b\u57fa\u3065\u3044\u3066\u904b\u52d5\u3001\u6804\u990a\u3001\u7761\u7720\u7ba1\u7406\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u500b\u5225\u5316\u30d7\u30e9\u30f3\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u7d71\u5408\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u7387\u3092\u5927\u5e45\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n

\u516c\u8846\u885b\u751f\u306e\u89b3\u70b9\u304b\u3089\u306e\u53d6\u308a\u7d44\u307f<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068\u516c\u8846\u885b\u751f\u306e\u7d71\u5408\u3082\u9032\u884c\u4e2d\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u7279\u5b9a\u306e\u5730\u57df\u3067\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u907a\u4f1d\u7684\u7279\u5fb4\u304c\u898b\u3089\u308c\u308b\u5834\u5408\u3001\u305d\u306e\u5730\u57df\u5411\u3051\u306b\u6700\u9069\u5316\u3055\u308c\u305f\u4e88\u9632\u7b56\u3092\u63d0\u4f9b\u3059\u308b\u8a66\u307f\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u53d6\u308a\u7d44\u307f\u306f\u3001\u56fd\u30ec\u30d9\u30eb\u3067\u306e\u533b\u7642\u8cbb\u524a\u6e1b\u3084\u793e\u4f1a\u7684\u8ca0\u62c5\u306e\u8efd\u6e1b\u306b\u8ca2\u732e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u8a8d\u77e5\u75c7\u3068\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u878d\u5408<\/strong><\/h4>\n\n\n\n
\u4eba\u5de5\u77e5\u80fd\uff08AI\uff09\u306b\u3088\u308b\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong><\/h5>\n\n\n\n

AI\u6280\u8853\u306f\u3001\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u306e\u7279\u5b9a\u3068\u65e9\u671f\u4e88\u6e2c\u306b\u304a\u3044\u3066\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3001\u751f\u6d3b\u7fd2\u6163\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3066\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306e\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u3092\u3088\u308a\u6b63\u78ba\u306b\u8a55\u4fa1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001AI\u3092\u7528\u3044\u3066APOE\u03b54\u30ad\u30e3\u30ea\u30a2\u306e\u60a3\u8005\u306e\u8133MRI\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u8133\u306e\u69cb\u9020\u7684\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u6280\u8853\u306b\u3088\u308a\u3001\u767a\u75c7\u524d\u306e\u6bb5\u968e\u3067\u306e\u30ea\u30b9\u30af\u8efd\u6e1b\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3068\u8a8d\u77e5\u75c7\u4e88\u9632<\/strong><\/h5>\n\n\n\n

\u8fd1\u5e74\u3001\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3092\u6d3b\u7528\u3057\u305f\u8a8d\u77e5\u75c7\u4e88\u9632\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30c7\u30d0\u30a4\u30b9\u306f\u3001\u5fc3\u62cd\u6570\u3001\u7761\u7720\u30d1\u30bf\u30fc\u30f3\u3001\u904b\u52d5\u91cf\u306a\u3069\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u8a18\u9332\u3057\u3001\u30c7\u30fc\u30bf\u3092\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u7d44\u307f\u5408\u308f\u305b\u3066\u89e3\u6790\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u904b\u52d5\u4e0d\u8db3\u3084\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u305f\u5834\u5408\u306b\u30a2\u30e9\u30fc\u30c8\u3092\u767a\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u65e9\u671f\u306e\u884c\u52d5\u4fee\u6b63\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u672a\u7136\u306b\u9632\u3050\u53d6\u308a\u7d44\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30d0\u30fc\u30c1\u30e3\u30eb\u30ea\u30a2\u30ea\u30c6\u30a3\uff08VR\uff09\u3068\u8a8d\u77e5\u6a5f\u80fd\u8a13\u7df4<\/strong><\/h5>\n\n\n\n

VR\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u8a8d\u77e5\u6a5f\u80fd\u8a13\u7df4\u3082\u3001\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u4eba\u3005\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u4ecb\u5165\u65b9\u6cd5\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7a7a\u9593\u8a8d\u77e5\u3084\u8a18\u61b6\u529b\u3092\u5f37\u5316\u3059\u308b\u305f\u3081\u306e\u30b2\u30fc\u30e0\u5f62\u5f0f\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3092\u5b9a\u671f\u7684\u306b\u884c\u3046\u3053\u3068\u3067\u8133\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3067\u304d\u307e\u3059\u3002VR\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u8a13\u7df4\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u63d0\u4f9b\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u30b0\u30ed\u30fc\u30d0\u30eb\u306a\u8996\u70b9<\/strong><\/h4>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\u4e16\u754c\u898f\u6a21\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u69cb\u7bc9<\/strong><\/h5>\n\n\n\n

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\u958b\u767a\u9014\u4e0a\u56fd\u3078\u306e\u5fdc\u7528<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u6210\u679c\u3092\u958b\u767a\u9014\u4e0a\u56fd\u306b\u666e\u53ca\u3055\u305b\u308b\u53d6\u308a\u7d44\u307f\u3082\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5730\u57df\u3067\u306f\u3001\u533b\u7642\u30ea\u30bd\u30fc\u30b9\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u7c21\u4fbf\u306a\u8840\u6db2\u691c\u67fb\u3084\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u57fa\u306b\u3057\u305f\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u91cd\u8981\u3067\u3059\u3002\u307e\u305f\u3001\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5730\u57df\u306b\u304a\u3044\u3066\u3001\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u516c\u8846\u885b\u751f\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\n\n\n\n

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\u5065\u5eb7\u7684\u306a\u98df\u4e8b\u7fd2\u6163<\/strong><\/h5>\n\n\n\n

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\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u3068\u8a8d\u77e5\u75c7\u4e88\u9632<\/strong><\/h5>\n\n\n\n

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\u793e\u4f1a\u7684\u3064\u306a\u304c\u308a\u306e\u91cd\u8981\u6027<\/strong><\/h5>\n\n\n\n

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\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u533b\u7642\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u502b\u7406\u7684\u8ab2\u984c<\/strong><\/h4>\n\n\n\n
\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77\u306e\u5fc5\u8981\u6027<\/strong><\/h5>\n\n\n\n

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\u4fdd\u967a\u3084\u96c7\u7528\u3067\u306e\u5dee\u5225\u30ea\u30b9\u30af<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u5b50\u60c5\u5831\u304c\u4fdd\u967a\u3084\u96c7\u7528\u306b\u304a\u3044\u3066\u5dee\u5225\u7684\u306b\u5229\u7528\u3055\u308c\u308b\u30ea\u30b9\u30af\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u7406\u7531\u306b\u3001\u4fdd\u967a\u6599\u304c\u9ad8\u304f\u8a2d\u5b9a\u3055\u308c\u305f\u308a\u3001\u63a1\u7528\u3067\u4e0d\u5229\u306b\u6271\u308f\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u30ea\u30b9\u30af\u3092\u56de\u907f\u3059\u308b\u305f\u3081\u3001\u5404\u56fd\u3067\u907a\u4f1d\u5b50\u5dee\u5225\u3092\u7981\u6b62\u3059\u308b\u6cd5\u5f8b\u306e\u6574\u5099\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u5207\u308a\u958b\u304f\u672a\u6765<\/strong><\/h4>\n\n\n\n
\u4e88\u9632\u91cd\u8996\u306e\u533b\u7642\u30e2\u30c7\u30eb<\/strong><\/h5>\n\n\n\n

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\u65b0\u85ac\u958b\u767a\u306e\u52a0\u901f<\/strong><\/h5>\n\n\n\n

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\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

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\"\"<\/figure>\n\n\n\n

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\n\n\n\n

\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u4f4e\u6e1b\u306b\u5411\u3051\u305f\u793e\u4f1a\u7684\u30a4\u30f3\u30d5\u30e9\u306e\u6574\u5099<\/strong><\/h4>\n\n\n\n
\u5730\u57df\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u3092\u6d3b\u7528\u3057\u305f\u4e88\u9632\u7b56<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u3005\u3078\u306e\u30b5\u30dd\u30fc\u30c8\u3092\u5730\u57df\u793e\u4f1a\u5168\u4f53\u3067\u884c\u3046\u53d6\u308a\u7d44\u307f\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u9ad8\u9f62\u8005\u5411\u3051\u306e\u8a8d\u77e5\u6a5f\u80fd\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u3084\u3001\u8a8d\u77e5\u75c7\u4e88\u9632\u306e\u305f\u3081\u306e\u5065\u5eb7\u30bb\u30df\u30ca\u30fc\u3092\u5730\u57df\u3067\u5b9f\u65bd\u3059\u308b\u3053\u3068\u304c\u52b9\u679c\u3092\u4e0a\u3052\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u6d3b\u52d5\u306f\u3001\u5b64\u7acb\u611f\u306e\u8efd\u6e1b\u3084\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u306b\u7e4b\u304c\u308a\u3001\u907a\u4f1d\u5b50\u7684\u306b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u3005\u306b\u3068\u3063\u3066\u3082\u8a8d\u77e5\u75c7\u767a\u75c7\u3092\u4e88\u9632\u3059\u308b\u74b0\u5883\u3065\u304f\u308a\u306e\u4e00\u74b0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u5065\u5eb7\u7ba1\u7406\u306e\u30c7\u30b8\u30bf\u30eb\u5316<\/strong><\/h5>\n\n\n\n

\u30c7\u30b8\u30bf\u30eb\u30c4\u30fc\u30eb\u3092\u6d3b\u7528\u3057\u305f\u8a8d\u77e5\u75c7\u4e88\u9632\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u30a2\u30d7\u30ea\u3092\u5229\u7528\u3057\u3066\u65e5\u3005\u306e\u8a8d\u77e5\u6a5f\u80fd\u3092\u8a18\u9332\u3057\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u63d0\u4f9b\u3059\u308b\u4ed5\u7d44\u307f\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u624b\u8efd\u306b\u30ea\u30b9\u30af\u3092\u628a\u63e1\u3057\u3001\u4e88\u9632\u306b\u5411\u3051\u305f\u884c\u52d5\u3092\u4fc3\u3059\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u516c\u5171\u653f\u7b56\u306e\u91cd\u8981\u6027<\/strong><\/h5>\n\n\n\n

\u8a8d\u77e5\u75c7\u4e88\u9632\u306b\u306f\u3001\u516c\u7684\u6a5f\u95a2\u306e\u652f\u63f4\u3084\u653f\u7b56\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002\u305f\u3068\u3048\u3070\u3001\u653f\u5e9c\u4e3b\u5c0e\u3067\u7121\u6599\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u3084\u5065\u5eb7\u8a3a\u65ad\u3092\u5b9f\u65bd\u3059\u308b\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u5404\u56fd\u3067\u5e83\u304c\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u533b\u7642\u5f93\u4e8b\u8005\u3078\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u5145\u5b9f\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6b63\u3057\u304f\u6d3b\u7528\u3067\u304d\u308b\u4f53\u5236\u304c\u69cb\u7bc9\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u8a8d\u77e5\u75c7\u3068\u907a\u4f1d\u5b50\u306e\u6b21\u4e16\u4ee3\u7814\u7a76<\/strong><\/h4>\n\n\n\n
\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u306e\u6d3b\u7528<\/strong><\/h5>\n\n\n\n

\u907a\u4f1d\u5b50\u7814\u7a76\u306f\u30b2\u30ce\u30e0\u89e3\u6790\u3060\u3051\u3067\u306a\u304f\u3001\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\uff08\u30bf\u30f3\u30d1\u30af\u8cea\u89e3\u6790\uff09\u3001\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\uff08\u4ee3\u8b1d\u7269\u89e3\u6790\uff09\u306a\u3069\u306e\u300c\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u300d\u7814\u7a76\u3078\u3068\u62e1\u5927\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8a8d\u77e5\u75c7\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5168\u4f53\u50cf\u304c\u3088\u308a\u6df1\u304f\u7406\u89e3\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001APOE\u03b54\u30ad\u30e3\u30ea\u30a2\u306e\u8133\u5185\u3067\u3069\u306e\u3088\u3046\u306b\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3059\u308b\u304b\u3092\u3001\u8907\u6570\u306e\u30c7\u30fc\u30bf\u5c64\u304b\u3089\u89e3\u6790\u3059\u308b\u7814\u7a76\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002<\/p>\n\n\n\n

\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u74b0\u5883\u56e0\u5b50\u306e\u7d71\u5408\u7814\u7a76<\/strong><\/h5>\n\n\n\n

\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306f\u3001\u74b0\u5883\u8981\u56e0\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u91cd\u8981\u306a\u5206\u91ce\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u55ab\u7159\u3084\u80a5\u6e80\u3068\u3044\u3063\u305f\u751f\u6d3b\u7fd2\u6163\u304c\u3001\u8a8d\u77e5\u75c7\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u3092\u300c\u30aa\u30f3\u300d\u306b\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u7684\u306b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u3067\u3082\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3092\u901a\u3058\u3066\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u8a8d\u77e5\u75c7\u4e88\u9632\u306e\u305f\u3081\u306e\u6559\u80b2\u3068\u5553\u767a\u6d3b\u52d5<\/strong><\/h4>\n\n\n\n
\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u666e\u53ca\u3068\u30ea\u30c6\u30e9\u30b7\u30fc\u5411\u4e0a<\/strong><\/h5>\n\n\n\n

\u8a8d\u77e5\u75c7\u4e88\u9632\u306e\u53d6\u308a\u7d44\u307f\u3092\u52b9\u679c\u7684\u306b\u9032\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u77e5\u8b58\u306e\u666e\u53ca\u304c\u91cd\u8981\u3067\u3059\u3002\u591a\u304f\u306e\u4eba\u304c\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u8aa4\u89e3\u3057\u305f\u308a\u3001\u4e0d\u5b89\u3092\u611f\u3058\u305f\u308a\u3057\u3066\u3044\u308b\u4e2d\u3001\u6b63\u78ba\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5fc5\u305a\u767a\u75c7\u3092\u610f\u5473\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u5f37\u8abf\u3057\u3001\u65e9\u671f\u306e\u4e88\u9632\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u304c\u52b9\u679c\u3092\u6301\u3064\u3053\u3068\u3092\u5e83\u3081\u308b\u5553\u767a\u6d3b\u52d5\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u9ad8\u9f62\u8005\u3078\u306e\u6559\u80b2\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/h5>\n\n\n\n

\u9ad8\u9f62\u8005\u5411\u3051\u306e\u6559\u80b2\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u306f\u3001\u8a8d\u77e5\u75c7\u4e88\u9632\u306e\u305f\u3081\u306e\u6804\u990a\u3001\u904b\u52d5\u3001\u7761\u7720\u7ba1\u7406\u306b\u52a0\u3048\u3001\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u5065\u5eb7\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u3005\u304c\u81ea\u3089\u306e\u72b6\u6cc1\u3092\u628a\u63e1\u3057\u3001\u9069\u5207\u306a\u884c\u52d5\u3092\u3068\u308b\u3053\u3068\u304c\u4fc3\u9032\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n

\u907a\u4f1d\u5b50\u7814\u7a76\u306f\u3001\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u306e\u7279\u5b9a\u304b\u3089\u4e88\u9632\u7b56\u3001\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u81f3\u308b\u307e\u3067\u3001\u73fe\u4ee3\u533b\u7642\u306b\u9769\u65b0\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u307e\u3059\u3002APOE\u3084TREM2\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u306e\u767a\u898b\u3084\u3001\u591a\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u306e\u6d3b\u7528\u306b\u3088\u308a\u3001\u500b\u3005\u306e\u30ea\u30b9\u30af\u3092\u6b63\u78ba\u306b\u8a55\u4fa1\u3057\u3001\u65e9\u671f\u4e88\u9632\u3084\u500b\u5225\u5316\u533b\u7642\u3092\u5b9f\u73fe\u3059\u308b\u57fa\u76e4\u304c\u6574\u3044\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u4ecb\u5165\u3084\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u5fdc\u7528\u306b\u3088\u308a\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u7de9\u548c\u3059\u308b\u5177\u4f53\u7684\u306a\u65b9\u6cd5\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77\u3084\u516c\u5e73\u6027\u306e\u78ba\u4fdd\u3068\u3044\u3063\u305f\u8ab2\u984c\u306b\u5bfe\u5fdc\u3057\u306a\u304c\u3089\u3001\u6301\u7d9a\u53ef\u80fd\u306a\u8a8d\u77e5\u75c7\u4e88\u9632\u306e\u5b9f\u73fe\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

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