{"id":10207,"date":"2025-03-17T08:52:31","date_gmt":"2025-03-17T08:52:31","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10207"},"modified":"2025-03-17T08:52:32","modified_gmt":"2025-03-17T08:52:32","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e4%bb%a3%e8%ac%9d%e7%96%be%e6%82%a3%e3%81%ae%e4%ba%88%e6%b8%ac%ef%bc%9a%e6%9c%80%e6%96%b0%e3%81%ae%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e4%bb%a3%e8%ac%9d%e7%96%be%e6%82%a3%e3%81%ae%e4%ba%88%e6%b8%ac%ef%bc%9a%e6%9c%80%e6%96%b0%e3%81%ae%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u4ee3\u8b1d\u75be\u60a3\u306e\u4e88\u6e2c\uff1a\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u3068\u4ee3\u8b1d\u75be\u60a3\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u4ee3\u8b1d\u75be\u60a3\u306f\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306a\u3069\u306e\u75be\u60a3\u7fa4\u3092\u6307\u3057\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u76f8\u4e92\u306b\u4f5c\u7528\u3057\u3066\u767a\u75c7\u3057\u307e\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u4ee3\u8b1d\u6a5f\u80fd\u306e\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306b\u306f<strong>TCF7L2\u907a\u4f1d\u5b50<\/strong>\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/ng\/\">\u53c2\u8003: Nature Genetics<\/a>)<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u80a5\u6e80\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066<strong>FTO\u907a\u4f1d\u5b50<\/strong>\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u98df\u6b32\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u96e3\u3057\u304f\u306a\u308a\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u91cf\u304c\u5897\u52a0\u3059\u308b\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u4ee3\u8b1d\u75be\u60a3\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8981\u56e0<\/strong><\/h2>\n\n\n\n<p>\u4ee3\u8b1d\u75be\u60a3\u306e\u767a\u75c7\u306b\u306f\u3001\u5358\u4e00\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3060\u3051\u3067\u306a\u304f\u3001\u8907\u6570\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u591a\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08Polygenic Risk Score: PRS\uff09\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u75be\u60a3\u30ea\u30b9\u30af\u3092\u3088\u308a\u9ad8\u7cbe\u5ea6\u306b\u4e88\u6e2c\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3068\u74b0\u5883\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3066\u3082\u3001\u9069\u5207\u306a\u751f\u6d3b\u7fd2\u6163\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u3067\u75be\u60a3\u306e\u767a\u75c7\u3092\u4e88\u9632\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>FTO\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\u3067\u3082\u3001\u9069\u5207\u306a\u98df\u4e8b\u3068\u904b\u52d5\u3092\u7d99\u7d9a\u3059\u308b\u3053\u3068\u3067\u3001\u80a5\u6e80\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(\u53c2\u8003: The Lancet Diabetes &amp; Endocrinology)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u9032\u6b69\u3068\u4e88\u6e2c\u7cbe\u5ea6\u306e\u5411\u4e0a<\/strong><\/h2>\n\n\n\n<p>\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08NGS\uff09\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3057\u3001\u4ee3\u8b1d\u75be\u60a3\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09<\/strong><\/h3>\n\n\n\n<p>GWAS\u306f\u3001\u5927\u898f\u6a21\u306a\u96c6\u56e3\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u7279\u5b9a\u306e\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7279\u5b9a\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002\u4f8b\u3048\u3070\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066<strong>TCF7L2\u3001KCNJ11\u3001PPARG<\/strong>\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(\u53c2\u8003: Genome Medicine)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u4ee3\u8b1d\u75be\u60a3<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306fDNA\u914d\u5217\u3060\u3051\u3067\u306a\u304f\u3001\u74b0\u5883\u8981\u56e0\u306b\u3088\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\uff08DNA\u30e1\u30c1\u30eb\u5316\u3001\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\uff09\u306b\u3088\u3063\u3066\u3082\u8abf\u7bc0\u3055\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u306e\u98df\u751f\u6d3b\u304c\u80ce\u5150\u306e\u4ee3\u8b1d\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u4e3b\u8981\u306a\u4ee3\u8b1d\u75be\u60a3\u3068\u95a2\u9023\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"434\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/2399658_s.jpg\" alt=\"\" class=\"wp-image-1245\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2399658_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/2399658_s-300x203.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff092\u578b\u7cd6\u5c3f\u75c5<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u9023\u907a\u4f1d\u5b50<\/strong>: <strong>TCF7L2\u3001KCNJ11\u3001PPARG\u3001SLC30A8<\/strong><\/li>\n\n\n\n<li><strong>\u5f71\u97ff<\/strong>: \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u4f4e\u4e0b\u3001\u8840\u7cd6\u5024\u306e\u4e0a\u6607<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09\u8102\u8cea\u7570\u5e38\u75c7<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u9023\u907a\u4f1d\u5b50<\/strong>: <strong>APOA5\u3001LDLR\u3001PCSK9<\/strong><\/li>\n\n\n\n<li><strong>\u5f71\u97ff<\/strong>: \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u306e\u7570\u5e38\u3001\u52d5\u8108\u786c\u5316\u306e\u30ea\u30b9\u30af\u5897\u52a0<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff083\uff09\u9ad8\u8840\u5727<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u9023\u907a\u4f1d\u5b50<\/strong>: <strong>AGT\u3001ACE\u3001NOS3<\/strong><\/li>\n\n\n\n<li><strong>\u5f71\u97ff<\/strong>: \u8840\u5727\u306e\u8abf\u7bc0\u7570\u5e38\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u306e\u5897\u52a0<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\u3068\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6d3b\u7528<\/strong><\/h2>\n\n\n\n<p>\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u6700\u9069\u306a\u6cbb\u7642\u3084\u751f\u6d3b\u7fd2\u6163\u3092\u63d0\u6848\u3059\u308b\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\u304c\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u7cd6\u5024\u306e\u7ba1\u7406<\/strong>: <strong>TCF7L2\u907a\u4f1d\u5b50\u5909\u7570<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u7cd6\u8cea\u5236\u9650\u3084\u9069\u5ea6\u306a\u904b\u52d5\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u7ba1\u7406<\/strong>: <strong>PCSK9\u907a\u4f1d\u5b50\u5909\u7570<\/strong>\u3092\u6301\u3064\u4eba\u306b\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u304c\u52b9\u679c\u7684\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u98df\u4e8b\u7642\u6cd5<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u7684\u306a\u4ee3\u8b1d\u80fd\u529b\u306b\u5fdc\u3058\u3066\u3001\u6700\u9069\u306a\u6804\u990a\u6442\u53d6\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>LCT\u907a\u4f1d\u5b50\u5909\u7570<\/strong>\u3092\u6301\u3064\u4eba\u306f\u4e73\u7cd6\u4e0d\u8010\u75c7\u306e\u305f\u3081\u3001\u4e73\u88fd\u54c1\u306e\u6442\u53d6\u3092\u63a7\u3048\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u4e88\u9632\u533b\u7642\u306e\u6700\u524d\u7dda\uff1a\u751f\u6d3b\u7fd2\u6163\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/22138195_m-1024x683.jpg\" alt=\"\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u30fb\u904b\u52d5\u3059\u308b\u5973\u6027\" class=\"wp-image-9599\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22138195_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22138195_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22138195_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22138195_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22138195_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5834\u5408\u3067\u3082\u3001\u9069\u5207\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u3067\u75be\u60a3\u3092\u4e88\u9632\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09\u904b\u52d5\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p><strong>ACE\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>\u306b\u3088\u3063\u3066\u3001\u6301\u4e45\u529b\u578b\u3068\u77ac\u767a\u529b\u578b\u306e\u904b\u52d5\u9069\u6027\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u9069\u5207\u306a\u904b\u52d5\u7fd2\u6163\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u4ee3\u8b1d\u306e\u52b9\u7387\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09\u98df\u751f\u6d3b\u3068\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u304c\u8c4a\u5bcc\u306a\u98df\u54c1\uff08\u9b5a\u3001\u30ca\u30c3\u30c4\u985e\uff09\u306f\u3001\u907a\u4f1d\u7684\u306b\u8102\u8cea\u7570\u5e38\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306e\u5065\u5eb7\u7dad\u6301\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u4eca\u5f8c\u306e\u5c55\u671b\u3068\u7814\u7a76\u306e\u65b9\u5411\u6027<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u75be\u60a3\u4e88\u6e2c<\/strong><\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u9032\u6b69\u306b\u3088\u308b\u4ee3\u8b1d\u75be\u60a3\u306e\u514b\u670d<\/strong><\/li>\n\n\n\n<li><strong>\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\uff08CRISPR\uff09\u306b\u3088\u308b\u75be\u60a3\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u53ef\u80fd\u6027<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c\u3092\u3082\u3068\u306b\u3001\u4eca\u5f8c\u306f\u3088\u308a\u7cbe\u5bc6\u306a\u75be\u60a3\u4e88\u6e2c\u3084\u500b\u5225\u5316\u533b\u7642\u304c\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306f\u3001\u7cd6\u5c3f\u75c5\u3084\u80a5\u6e80\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u305d\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09IRS1\u907a\u4f1d\u5b50\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/strong><\/h3>\n\n\n\n<p><strong>IRS1\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u57fa\u8cea1\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u7d30\u80de\u306b\u4fe1\u53f7\u3092\u4f1d\u3048\u308b\u969b\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002(<a href=\"https:\/\/diabetesjournals.org\/\">\u53c2\u8003: Diabetes Journal<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u4f4e\u4e0b\u3057\u3001\u8840\u7cd6\u5024\u304c\u4e0a\u6607\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u3001\u8840\u7cd6\u5024\u306e\u8abf\u6574\u304c\u30b9\u30e0\u30fc\u30ba\u306b\u884c\u308f\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09PPARG\u907a\u4f1d\u5b50\u3068\u8102\u80aa\u7d30\u80de\u306e\u5f79\u5272<\/strong><\/h3>\n\n\n\n<p><strong>PPARG\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b3\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u8102\u80aa\u7d30\u80de\u306e\u5f62\u6210\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PPARG\u5909\u7570\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/li>\n\n\n\n<li><strong>PPARG\u6d3b\u6027\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u8102\u80aa\u7d30\u80de\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u304c\u30b9\u30e0\u30fc\u30ba\u306b\u306a\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6700\u9069\u5316\u3059\u308b\u305f\u3081\u306b\u3001\u9069\u5ea6\u306a\u904b\u52d5\u3068\u5065\u5eb7\u7684\u306a\u98df\u4e8b\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u809d\u81d3\u306e\u8102\u80aa\u4ee3\u8b1d\u3068\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31082610_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9231\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31082610_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31082610_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31082610_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31082610_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31082610_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u809d\u81d3\u306e\u8102\u80aa\u84c4\u7a4d\u306f\u3001\u8102\u80aa\u809d\u3084\u809d\u786c\u5909\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u305d\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09PNPLA3\u907a\u4f1d\u5b50\u3068\u8102\u80aa\u809d\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p><strong>PNPLA3\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u95a2\u9023\u30ea\u30d1\u30fc\u30bc3\uff09\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306f\u3001\u809d\u81d3\u306e\u8102\u80aa\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u8102\u80aa\u809d\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/aasldpubs.onlinelibrary.wiley.com\/journal\/15273350\">\u53c2\u8003: Hepatology Journal<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PNPLA3\u5909\u7570\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u8102\u80aa\u304c\u809d\u81d3\u306b\u84c4\u7a4d\u3057\u3084\u3059\u304f\u3001NAFLD\uff08\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u75be\u60a3\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u306e\u4eba\u306f\u3001\u809d\u81d3\u306e\u8102\u80aa\u4ee3\u8b1d\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u3001\u8102\u80aa\u809d\u306b\u306a\u308a\u306b\u304f\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09TM6SF2\u907a\u4f1d\u5b50\u3068\u809d\u75be\u60a3<\/strong><\/h3>\n\n\n\n<p><strong>TM6SF2\u907a\u4f1d\u5b50<\/strong>\u3082\u809d\u81d3\u306e\u8102\u80aa\u84c4\u7a4d\u306b\u95a2\u9023\u3057\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u8102\u80aa\u809d\u3084\u809d\u786c\u5909\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u809d\u81d3\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u9069\u5207\u306a\u98df\u4e8b\u7ba1\u7406\u3068\u5b9a\u671f\u7684\u306a\u904b\u52d5\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4ee3\u8b1d\u7570\u5e38\u306f\u3001\u52d5\u8108\u786c\u5316\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5f37\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09LDLR\u907a\u4f1d\u5b50\u3068\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7<\/strong><\/h3>\n\n\n\n<p><strong>LDLR\uff08\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306f\u3001\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff08FH\uff09\u306e\u539f\u56e0\u3068\u306a\u308a\u3001\u65e9\u671f\u306e\u52d5\u8108\u786c\u5316\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002(\u53c2\u8003: Circulation Journal)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u6392\u51fa\u3055\u308c\u306b\u304f\u304f\u3001\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9069\u5207\u306b\u4ee3\u8b1d\u3055\u308c\u3001\u52d5\u8108\u786c\u5316\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09PCSK9\u907a\u4f1d\u5b50\u3068\u8102\u8cea\u7570\u5e38<\/strong><\/h3>\n\n\n\n<p><strong>PCSK9\u907a\u4f1d\u5b50<\/strong>\u306f\u3001LDL\u53d7\u5bb9\u4f53\u306e\u5206\u89e3\u3092\u8abf\u7bc0\u3057\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u84c4\u7a4d\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b\u3092\u6301\u3064\u4eba<\/strong>\u306f\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u904e\u5270\u306b\u84c4\u7a4d\u3057\u3084\u3059\u304f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4ee3\u8b1d\u304c\u6b63\u5e38\u306b\u884c\u308f\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>PCSK9\u963b\u5bb3\u85ac\u306f\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>11. \u9ad8\u8840\u5727\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h2>\n\n\n\n<p>\u8840\u5727\u306e\u8abf\u7bc0\u306b\u3082\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3001\u9ad8\u8840\u5727\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09AGT\u907a\u4f1d\u5b50\u3068\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb<\/strong><\/h3>\n\n\n\n<p><strong>AGT\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\uff09\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306f\u3001\u8840\u5727\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002(\u53c2\u8003: Hypertension Journal)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AGT\u9ad8\u767a\u73fe\u578b<\/strong>\uff1a\u8840\u5727\u304c\u4e0a\u6607\u3057\u3084\u3059\u304f\u3001\u9ad8\u8840\u5727\u306b\u306a\u308a\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>AGT\u4f4e\u767a\u73fe\u578b<\/strong>\uff1a\u8840\u5727\u306e\u4e0a\u6607\u304c\u6291\u3048\u3089\u308c\u3001\u8840\u7ba1\u306e\u5065\u5eb7\u304c\u7dad\u6301\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09ACE\u907a\u4f1d\u5b50\u3068\u8840\u7ba1\u306e\u5f3e\u529b\u6027<\/strong><\/h3>\n\n\n\n<p><strong>ACE\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u8840\u7ba1\u306e\u53ce\u7e2e\u3068\u62e1\u5f35\u3092\u8abf\u7bc0\u3057\u3001\u8840\u5727\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DD\u578b<\/strong>\uff1a\u8840\u5727\u304c\u4e0a\u304c\u308a\u3084\u3059\u304f\u3001\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>II\u578b<\/strong>\uff1a\u8840\u5727\u304c\u5b89\u5b9a\u3057\u3084\u3059\u304f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306f\u3001\u6e1b\u5869\u98df\u3084\u30ab\u30ea\u30a6\u30e0\u6442\u53d6\u3092\u610f\u8b58\u3057\u305f\u98df\u751f\u6d3b\u3092\u9001\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>12. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u4ee3\u8b1d\u75be\u60a3\u306e\u6cbb\u7642<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"796\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-1024x796.jpg\" alt=\"\u7814\u7a76\u5ba4\u3000\u5973\u6027\" class=\"wp-image-7704\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-1024x796.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-300x233.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-768x597.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-1536x1194.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR-Cas9\u306a\u3069\uff09\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u57fa\u3065\u304f\u75be\u60a3\u306e\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09CRISPR-Cas9\u306b\u3088\u308b\u907a\u4f1d\u5b50\u4fee\u6b63<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PCSK9\u907a\u4f1d\u5b50\u306e\u4fee\u6b63<\/strong>\u306b\u3088\u308a\u3001\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>PPARG\u907a\u4f1d\u5b50\u306e\u8abf\u6574<\/strong>\u306b\u3088\u3063\u3066\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8102\u80aa\u809d\u306e\u4e88\u9632<\/strong>\uff1aPNPLA3\u907a\u4f1d\u5b50\u306e\u8abf\u6574\u306b\u3088\u308b\u8102\u80aa\u84c4\u7a4d\u306e\u6291\u5236\u3002<\/li>\n\n\n\n<li><strong>\u7cd6\u5c3f\u75c5\u6cbb\u7642<\/strong>\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u6700\u9069\u5316\u3059\u308b\u907a\u4f1d\u5b50\u7642\u6cd5\u306e\u958b\u767a\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u304c\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u4ee3\u8b1d\u75be\u60a3\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u304c\u98db\u8e8d\u7684\u306b\u9032\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>13. \u80a5\u6e80\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h2>\n\n\n\n<p>\u80a5\u6e80\u306e\u767a\u75c7\u306b\u306f\u3001\u74b0\u5883\u8981\u56e0\uff08\u98df\u4e8b\u30fb\u904b\u52d5\u4e0d\u8db3\uff09\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3082\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09FTO\u907a\u4f1d\u5b50\u3068\u98df\u6b32\u5236\u5fa1<\/strong><\/h3>\n\n\n\n<p><strong>FTO\uff08Fat mass and obesity-associated\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u98df\u6b32\u306e\u8abf\u6574\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/ng\/\">\u53c2\u8003: Nature Genetics<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u578b\uff08AA\u578b\uff09<\/strong>\uff1a\u98df\u6b32\u304c\u5897\u52a0\u3057\u3084\u3059\u304f\u3001\u80a5\u6e80\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u4e2d\u9593\u578b\uff08AT\u578b\uff09<\/strong>\uff1a\u9069\u5ea6\u306a\u30ea\u30b9\u30af\u304c\u3042\u308b\u304c\u3001\u98df\u4e8b\u7ba1\u7406\u3067\u5f71\u97ff\u3092\u6291\u3048\u3089\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b\uff08TT\u578b\uff09<\/strong>\uff1a\u98df\u6b32\u304c\u5b89\u5b9a\u3057\u3001\u4f53\u91cd\u7ba1\u7406\u304c\u3057\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09LEPR\u907a\u4f1d\u5b50\u3068\u30ec\u30d7\u30c1\u30f3\u611f\u53d7\u6027<\/strong><\/h3>\n\n\n\n<p><strong>LEPR\uff08\u30ec\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u98df\u6b32\u3092\u6291\u5236\u3059\u308b\u30db\u30eb\u30e2\u30f3\u300c\u30ec\u30d7\u30c1\u30f3\u300d\u306e\u50cd\u304d\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b\u3092\u6301\u3064\u4eba<\/strong>\u306f\u3001\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u304c\u9ad8\u307e\u308a\u3001\u6e80\u8179\u611f\u3092\u611f\u3058\u306b\u304f\u304f\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u30ec\u30d7\u30c1\u30f3\u304c\u6b63\u5e38\u306b\u4f5c\u7528\u3057\u3001\u98df\u6b32\u304c\u9069\u5207\u306b\u5236\u5fa1\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3084\u30ab\u30ed\u30ea\u30fc\u6442\u53d6\u91cf\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u3001\u80a5\u6e80\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>14. \u4ee3\u8b1d\u75be\u60a3\u3068\u8178\u5185\u7d30\u83cc\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u306f\u3001\u4ee3\u8b1d\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3001\u8178\u5185\u7d30\u83cc\u306e\u69cb\u6210\u304c\u7570\u306a\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027<\/strong><\/h3>\n\n\n\n<p><strong>FUT2\uff08\u30d5\u30b3\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc2\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u5b9a\u7740\u306b\u95a2\u4e0e\u3057\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u591a\u69d8\u6027\u3092\u6c7a\u5b9a\u3057\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/nmicrobiol\/\">\u53c2\u8003: Nature Microbiology<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u975e\u6d3b\u6027\u578b\uff08AA\u578b\uff09<\/strong>\uff1a\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u304c\u4f4e\u304f\u3001\u8178\u5185\u74b0\u5883\u304c\u60aa\u5316\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u6d3b\u6027\u578b\uff08GG\u578b\uff09<\/strong>\uff1a\u5584\u7389\u83cc\u306e\u5b9a\u7740\u304c\u826f\u597d\u3067\u3001\u8178\u5185\u74b0\u5883\u304c\u5b89\u5b9a\u3057\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09\u77ed\u9396\u8102\u80aa\u9178\u3068\u4ee3\u8b1d\u8abf\u6574<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u304c\u4f5c\u308a\u51fa\u3059**\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09**\u306f\u3001\u8102\u8cea\u4ee3\u8b1d\u3084\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SCFA\u7523\u751f\u304c\u591a\u3044\u4eba<\/strong>\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u8840\u7cd6\u5024\u304c\u5b89\u5b9a\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>SCFA\u7523\u751f\u304c\u5c11\u306a\u3044\u4eba<\/strong>\u306f\u3001\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u305f\u3081\u306b\u3001\u767a\u9175\u98df\u54c1\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u7d0d\u8c46\uff09\u3001\u98df\u7269\u7e4a\u7dad\uff08\u91ce\u83dc\u3001\u8c46\u985e\uff09\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>15. \u907a\u4f1d\u5b50\u3068\u904b\u52d5\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"682\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/28129899_m-1024x682.jpg\" alt=\"\u30e9\u30f3\u30cb\u30f3\u30b0\u3059\u308b\u7537\u6027\u306e\u8db3\u5143\" class=\"wp-image-3601\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28129899_m-1024x682.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28129899_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28129899_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28129899_m-1536x1023.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/28129899_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u904b\u52d5\u306e\u52b9\u679c\u3082\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09AMPK\u907a\u4f1d\u5b50\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p><strong>AMPK\uff08AMP\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u904b\u52d5\u6642\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u8abf\u6574\u3057\u307e\u3059\u3002(\u53c2\u8003: Journal of Applied Physiology)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u767a\u73fe\u578b<\/strong>\uff1a\u6709\u9178\u7d20\u904b\u52d5\u306e\u52b9\u679c\u304c\u9ad8\u304f\u3001\u6301\u4e45\u529b\u304c\u5411\u4e0a\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u767a\u73fe\u578b<\/strong>\uff1a\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u304c\u52b9\u7387\u7684\u3067\u306a\u304f\u3001\u904b\u52d5\u306e\u9069\u5fdc\u306b\u6642\u9593\u304c\u304b\u304b\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09ACTN3\u907a\u4f1d\u5b50\u3068\u7b4b\u529b<\/strong><\/h3>\n\n\n\n<p><strong>ACTN3\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u901f\u7b4b\u3068\u9045\u7b4b\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>RR\u578b<\/strong>\uff1a\u30b9\u30d7\u30ea\u30f3\u30c8\u3084\u91cd\u91cf\u6319\u3052\u306b\u9069\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>XX\u578b<\/strong>\uff1a\u6301\u4e45\u529b\u7cfb\u306e\u904b\u52d5\u306b\u9069\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3001\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u3001\u4ee3\u8b1d\u3092\u52b9\u7387\u7684\u306b\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>16. \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u4ee3\u8b1d\u75be\u60a3\u306e\u95a2\u9023\u6027<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306f\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09DNA\u30e1\u30c1\u30eb\u5316\u3068\u80a5\u6e80<\/strong><\/h3>\n\n\n\n<p><strong>DNA\u30e1\u30c1\u30eb\u5316<\/strong>\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u4ed5\u7d44\u307f\u306e\u4e00\u3064\u3067\u3059\u3002\u80a5\u6e80\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u3067\u306f\u3001\u8102\u80aa\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316\u304c\u7570\u5e38\u306b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(\u53c2\u8003: Epigenetics Journal)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5065\u5eb7\u7684\u306a\u98df\u751f\u6d3b<\/strong>\u306f\u3001\u30e1\u30c1\u30eb\u5316\u3092\u9069\u5207\u306b\u7dad\u6301\u3057\u3001\u4ee3\u8b1d\u3092\u5b89\u5b9a\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li><strong>\u9ad8\u8102\u80aa\u30fb\u9ad8\u7cd6\u8cea\u306e\u98df\u4e8b<\/strong>\u306f\u3001\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09\u904b\u52d5\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9<\/strong><\/h3>\n\n\n\n<p>\u904b\u52d5\u306b\u3088\u3063\u3066\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u304c\u8d77\u3053\u308a\u3001\u4ee3\u8b1d\u6a5f\u80fd\u304c\u6539\u5584\u3055\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6301\u4e45\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\u306f\u3001\u8102\u80aa\u71c3\u713c\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\u306f\u3001\u7cd6\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>17. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5c55<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-1024x683.jpg\" alt=\"PC\u3067\u4f5c\u696d\u3059\u308b\u533b\u7642\u5f93\u4e8b\u8005\" class=\"wp-image-9562\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31033284_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6cbb\u7642\u3084\u4e88\u9632\u7b56\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09\u591a\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u306e\u6d3b\u7528<\/strong><\/h3>\n\n\n\n<p>**\u591a\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09**\u306f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7d71\u5408\u3057\u3001\u75be\u60a3\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u624b\u6cd5\u3067\u3059\u3002(<a href=\"https:\/\/www.nature.com\/nm\/\">\u53c2\u8003: Nature Medicine<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u30ea\u30b9\u30af\u306e\u4eba<\/strong>\u306b\u306f\u3001\u65e9\u671f\u306e\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3084\u85ac\u7269\u7642\u6cd5\u304c\u63a8\u5968\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u30ea\u30b9\u30af\u306e\u4eba<\/strong>\u3067\u3082\u3001\u5b9a\u671f\u7684\u306a\u5065\u5eb7\u7ba1\u7406\u304c\u91cd\u8981\u3068\u306a\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09AI\u3068\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u878d\u5408<\/strong><\/h3>\n\n\n\n<p>\u4eba\u5de5\u77e5\u80fd\uff08AI\uff09\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u3088\u308a\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u5065\u5eb7\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u304c\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u4e88\u9632\u6226\u7565\u3092\u63d0\u6848<\/strong><\/li>\n\n\n\n<li><strong>\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u3001\u65b0\u305f\u306a\u907a\u4f1d\u5b50\u30de\u30fc\u30ab\u30fc\u3092\u7279\u5b9a<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u3088\u308a\u52b9\u679c\u7684\u306a\u500b\u5225\u5316\u533b\u7642\u304c\u5b9f\u73fe\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>18. \u907a\u4f1d\u5b50\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u5185\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u7523\u751f\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u305d\u306e\u6a5f\u80fd\u306f\u4ee3\u8b1d\u75be\u60a3\u306e\u767a\u75c7\u306b\u5927\u304d\u304f\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09PGC-1\u03b1\u907a\u4f1d\u5b50\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5897\u52a0<\/strong><\/h3>\n\n\n\n<p><strong>PPARGC1A\uff08PGC-1\u03b1\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u6210\u3092\u4fc3\u9032\u3057\u3001\u4ee3\u8b1d\u6a5f\u80fd\u3092\u8abf\u6574\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002(\u53c2\u8003: Cell Metabolism)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u767a\u73fe\u578b<\/strong>\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6570\u304c\u591a\u304f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u304c\u826f\u597d\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u767a\u73fe\u578b<\/strong>\uff1a\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u304c\u60aa\u304f\u3001\u6301\u4e45\u529b\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>PGC-1\u03b1\u3092\u6d3b\u6027\u5316\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u6709\u9178\u7d20\u904b\u52d5\u3084\u6297\u9178\u5316\u98df\u54c1\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09NDUFS4\u907a\u4f1d\u5b50\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5<\/strong><\/h3>\n\n\n\n<p><strong>NDUFS4\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u96fb\u5b50\u4f1d\u9054\u7cfb\u306e\u8907\u5408\u4f53I\u306b\u95a2\u4e0e\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b\u3092\u6301\u3064\u4eba<\/strong>\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u6162\u6027\u7684\u306a\u75b2\u52b4\u3084\u4ee3\u8b1d\u7570\u5e38\u304c\u751f\u3058\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001ATP\u7523\u751f\u304c\u30b9\u30e0\u30fc\u30ba\u306b\u884c\u308f\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u3001\u30d3\u30bf\u30df\u30f3B\u7fa4\u3084\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u306e\u6442\u53d6\u304c\u52b9\u679c\u7684\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>19. \u7532\u72b6\u817a\u6a5f\u80fd\u3068\u4ee3\u8b1d\u75be\u60a3\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306f\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u3084\u4f53\u6e29\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09DIO2\u907a\u4f1d\u5b50\u3068\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u6d3b\u6027<\/strong><\/h3>\n\n\n\n<p><strong>DIO2\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u6d3b\u6027\u5316\u3092\u8abf\u6574\u3057\u3001\u57fa\u790e\u4ee3\u8b1d\u7387\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002(\u53c2\u8003: The Journal of Clinical Endocrinology &amp; Metabolism)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u767a\u73fe\u578b<\/strong>\uff1a\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u6d3b\u6027\u304c\u9ad8\u304f\u3001\u4ee3\u8b1d\u304c\u901f\u3044\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u767a\u73fe\u578b<\/strong>\uff1a\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u304c\u4f4e\u4e0b\u3057\u3001\u4f53\u91cd\u5897\u52a0\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7532\u72b6\u817a\u6a5f\u80fd\u3092\u6700\u9069\u5316\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30e8\u30a6\u7d20\u3084\u30bb\u30ec\u30f3\u3092\u542b\u3080\u98df\u54c1\uff08\u6d77\u85fb\u3001\u30ca\u30c3\u30c4\u985e\uff09\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09TSHR\u907a\u4f1d\u5b50\u3068\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7<\/strong><\/h3>\n\n\n\n<p><strong>TSHR\uff08\u7532\u72b6\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306f\u3001\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001\u6162\u6027\u7684\u306a\u75b2\u52b4\u3084\u4f53\u91cd\u5897\u52a0\u304c\u751f\u3058\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u304c\u9069\u5207\u306b\u5206\u6ccc\u3055\u308c\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u30d0\u30e9\u30f3\u30b9\u304c\u7dad\u6301\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u9069\u5207\u306a\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3084\u9069\u5ea6\u306a\u904b\u52d5\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>20. \u30d3\u30bf\u30df\u30f3D\u3068\u4ee3\u8b1d\u6a5f\u80fd\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-1024x681.jpg\" alt=\"\" class=\"wp-image-9680\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/22271584_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u9aa8\u306e\u5065\u5eb7\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u4ee3\u8b1d\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09VDR\u907a\u4f1d\u5b50\u3068\u30d3\u30bf\u30df\u30f3D\u611f\u53d7\u6027<\/strong><\/h3>\n\n\n\n<p><strong>VDR\uff08\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u4f5c\u7528\u3092\u8abf\u7bc0\u3057\u3001\u9aa8\u5bc6\u5ea6\u3084\u514d\u75ab\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/journal\/bone-reports\">\u53c2\u8003: Bone Reports<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u767a\u73fe\u578b<\/strong>\uff1a\u30d3\u30bf\u30df\u30f3D\u306e\u52b9\u679c\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u9aa8\u5bc6\u5ea6\u304c\u7dad\u6301\u3055\u308c\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u767a\u73fe\u578b<\/strong>\uff1a\u30d3\u30bf\u30df\u30f3D\u306e\u4f5c\u7528\u304c\u5f31\u304f\u3001\u9aa8\u7c97\u9b06\u75c7\u3084\u4ee3\u8b1d\u7570\u5e38\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09CYP2R1\u907a\u4f1d\u5b50\u3068\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p><strong>CYP2R1\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3057\u3001\u8840\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u5438\u53ce\u304c\u4f4e\u4e0b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u304c\u9069\u5207\u306b\u884c\u308f\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306e\u9069\u5207\u306a\u6442\u53d6\uff08\u9b5a\u3001\u5375\u3001\u65e5\u5149\u6d74\uff09\u304c\u3001\u5065\u5eb7\u7dad\u6301\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>21. \u751f\u6d3b\u7fd2\u6163\u75c5\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u76f8\u4e92\u306b\u4f5c\u7528\u3057\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u767a\u75c7\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09\u55ab\u7159\u3068\u4ee3\u8b1d\u75be\u60a3\u306e\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p>\u55ab\u7159\u306f\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u4ee3\u8b1d\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002(\u53c2\u8003: Tobacco Control Journal)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CYP1A1\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u30bf\u30d0\u30b3\u306e\u6709\u5bb3\u7269\u8cea\u3092\u89e3\u6bd2\u3057\u306b\u304f\u304f\u3001\u304c\u3093\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002<\/li>\n\n\n\n<li><strong>GSTT1\u907a\u4f1d\u5b50\u306e\u6b20\u640d<\/strong>\u306f\u3001\u6d3b\u6027\u9178\u7d20\u306e\u89e3\u6bd2\u80fd\u529b\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7981\u7159\u306b\u3088\u3063\u3066\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09\u30a2\u30eb\u30b3\u30fc\u30eb\u4ee3\u8b1d\u3068\u907a\u4f1d\u7684\u500b\u4f53\u5dee<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u4ee3\u8b1d\u80fd\u529b\u306f\u3001\u907a\u4f1d\u7684\u306b\u6c7a\u307e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ALDH2\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u5206\u89e3\u304c\u9045\u304f\u3001\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>ADH1B\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u7d20\u65e9\u304f\u5206\u89e3\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u9069\u91cf\u306e\u98f2\u9152\u3092\u5fc3\u304c\u3051\u308b\u3053\u3068\u3067\u3001\u4ee3\u8b1d\u3078\u306e\u60aa\u5f71\u97ff\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>22. \u814e\u6a5f\u80fd\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u9023\u6027<\/strong><\/h2>\n\n\n\n<p>\u814e\u81d3\u306e\u6a5f\u80fd\u3082\u907a\u4f1d\u7684\u8981\u56e0\u306b\u5f71\u97ff\u3055\u308c\u3001\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u306e\u30ea\u30b9\u30af\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09APOL1\u907a\u4f1d\u5b50\u3068\u814e\u75be\u60a3\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n<p><strong>APOL1\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306f\u3001\u814e\u75be\u60a3\u306e\u767a\u75c7\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002(\u53c2\u8003: Journal of the American Society of Nephrology)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b\u3092\u6301\u3064\u4eba<\/strong>\u306f\u3001\u6162\u6027\u814e\u81d3\u75c5\u3084\u814e\u4e0d\u5168\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u814e\u6a5f\u80fd\u304c\u5b89\u5b9a\u3057\u3066\u7dad\u6301\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u9069\u5207\u306a\u6c34\u5206\u6442\u53d6\u3068\u5869\u5206\u7ba1\u7406\u304c\u3001\u814e\u81d3\u306e\u5065\u5eb7\u3092\u5b88\u308b\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>23. \u7761\u7720\u3068\u4ee3\u8b1d\u306e\u907a\u4f1d\u7684\u95a2\u9023\u6027<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31692558_m-1024x683.jpg\" alt=\"\" class=\"wp-image-8885\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692558_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692558_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692558_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692558_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31692558_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7761\u7720\u306e\u8cea\u3084\u30ea\u30ba\u30e0\u306f\u4ee3\u8b1d\u6a5f\u80fd\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09CLOCK\u907a\u4f1d\u5b50\u3068\u6982\u65e5\u30ea\u30ba\u30e0<\/strong><\/h3>\n\n\n\n<p><strong>CLOCK\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u4f53\u5185\u6642\u8a08\uff08\u6982\u65e5\u30ea\u30ba\u30e0\uff09\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3057\u3001\u4ee3\u8b1d\u6a5f\u80fd\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002(\u53c2\u8003: Sleep Journal)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u7761\u7720\u306e\u30ea\u30ba\u30e0\u304c\u5b89\u5b9a\u3057\u3001\u4ee3\u8b1d\u6a5f\u80fd\u304c\u7dad\u6301\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u9069\u5207\u306a\u5149\u74b0\u5883\u3084\u7761\u7720\u7fd2\u6163\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u3001\u4ee3\u8b1d\u6a5f\u80fd\u306e\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09PER3\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u9577\u3055<\/strong><\/h3>\n\n\n\n<p><strong>PER3\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u7761\u7720\u306e\u9577\u3055\u3084\u8cea\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9577\u578b\u5909\u7570<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u9577\u6642\u9593\u306e\u7761\u7720\u3092\u5fc5\u8981\u3068\u3057\u3001\u7761\u7720\u4e0d\u8db3\u304c\u4ee3\u8b1d\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u77ed\u578b\u5909\u7570<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u77ed\u6642\u9593\u7761\u7720\u3067\u3082\u5f71\u97ff\u3092\u53d7\u3051\u306b\u304f\u3044\u304c\u3001\u9577\u671f\u7684\u306b\u306f\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u591c\u9593\u306e\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3092\u907f\u3051\u3001\u9069\u5207\u306a\u7761\u7720\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>24. \u708e\u75c7\u3068\u4ee3\u8b1d\u75be\u60a3\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h2>\n\n\n\n<p>\u6162\u6027\u708e\u75c7\u306f\u3001\u4ee3\u8b1d\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff081\uff09IL6\u907a\u4f1d\u5b50\u3068\u708e\u75c7\u53cd\u5fdc<\/strong><\/h3>\n\n\n\n<p><strong>IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u8abf\u7bc0\u3057\u3001\u7cd6\u5c3f\u75c5\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002(<a href=\"https:\/\/www.jimmunol.org\/\">\u53c2\u8003: The Journal of Immunology<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u767a\u73fe\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u708e\u75c7\u304c\u904e\u5270\u306b\u306a\u308a\u3001\u4ee3\u8b1d\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u767a\u73fe\u578b<\/strong>\u3067\u306f\u3001\u708e\u75c7\u304c\u9069\u5207\u306b\u5236\u5fa1\u3055\u308c\u3001\u5065\u5eb7\u304c\u7dad\u6301\u3055\u308c\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u30ea\u30b9\u30af\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\uff082\uff09TNF\u907a\u4f1d\u5b50\u3068\u8102\u80aa\u7d30\u80de\u306e\u708e\u75c7<\/strong><\/h3>\n\n\n\n<p><strong>TNF-\u03b1\uff08\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u03b1\uff09\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306f\u3001\u8102\u80aa\u7d30\u80de\u306e\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5909\u7570\u578b<\/strong>\u3092\u6301\u3064\u4eba\u306f\u3001\u80a5\u6e80\u306b\u3088\u308b\u708e\u75c7\u304c\u60aa\u5316\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u901a\u5e38\u578b<\/strong>\u3067\u306f\u3001\u8102\u80aa\u7d30\u80de\u306e\u708e\u75c7\u304c\u9069\u5207\u306b\u5236\u5fa1\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u9069\u5207\u306a\u904b\u52d5\u3068\u6297\u708e\u75c7\u98df\u54c1\u306e\u6442\u53d6\u304c\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u88dc\u3046\u624b\u6bb5\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator 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class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>1. \u907a\u4f1d\u5b50\u3068\u4ee3\u8b1d\u75be\u60a3\u306e\u95a2\u4fc2 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[&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":10208,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"tags":[40,41,53,59,36,49,45,55],"class_list":["post-10207","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-basicknowledge","tag-privacy","tag-personalized-medicine","tag-parent-child-relationship","tag-59","tag-gene-testing","tag-gene-analysis","tag-genetics","tag-genetic-diseases"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=10207"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10207\/revisions"}],"predecessor-version":[{"id":10215,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10207\/revisions\/10215"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/10208"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=10207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=10207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=10207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}