{"id":10248,"date":"2025-03-18T06:48:18","date_gmt":"2025-03-18T06:48:18","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10248"},"modified":"2025-03-18T06:48:19","modified_gmt":"2025-03-18T06:48:19","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e4%bd%93%e6%b8%a9%e8%aa%bf%e7%af%80%ef%bc%9a%e5%81%a5%e5%ba%b7%e7%ae%a1%e7%90%86%e3%81%ab%e5%bd%b9%e7%ab%8b%e3%81%a4%e7%9f%a5%e8%ad%98","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e4%bd%93%e6%b8%a9%e8%aa%bf%e7%af%80%ef%bc%9a%e5%81%a5%e5%ba%b7%e7%ae%a1%e7%90%86%e3%81%ab%e5%bd%b9%e7%ab%8b%e3%81%a4%e7%9f%a5%e8%ad%98\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u4f53\u6e29\u8abf\u7bc0\uff1a\u5065\u5eb7\u7ba1\u7406\u306b\u5f79\u7acb\u3064\u77e5\u8b58"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u306f\u3058\u3081\u306b<\/strong><\/h2>\n\n\n\n<p>\u4f53\u6e29\u306f\u751f\u547d\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u8981\u7d20\u3067\u3042\u308a\u3001\u79c1\u305f\u3061\u306e\u4f53\u306f\u5916\u90e8\u74b0\u5883\u306e\u5909\u5316\u306b\u9069\u5fdc\u3057\u306a\u304c\u3089\u4f53\u6e29\u3092\u4e00\u5b9a\u306b\u4fdd\u3064\u4ed5\u7d44\u307f\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4f53\u6e29\u8abf\u7bc0\u6a5f\u80fd\u306f\u3001\u795e\u7d4c\u7cfb\u3084\u30db\u30eb\u30e2\u30f3\u7cfb\u306e\u50cd\u304d\u306b\u52a0\u3048\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u4f53\u6e29\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u304c\u500b\u4eba\u306e\u9069\u5fdc\u80fd\u529b\u3084\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u907a\u4f1d\u5b50\u304c\u3069\u306e\u3088\u3046\u306b\u4f53\u6e29\u8abf\u7bc0\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u307e\u305f\u3001\u305d\u308c\u304c\u5065\u5eb7\u7ba1\u7406\u306b\u3069\u306e\u3088\u3046\u306b\u5f79\u7acb\u3064\u306e\u304b\u3092\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u8abf\u7bc0\u306e\u57fa\u672c\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u306e\u7dad\u6301\u3068\u305d\u306e\u91cd\u8981\u6027<\/strong><\/h3>\n\n\n\n<p>\u4eba\u9593\u306e\u6b63\u5e38\u306a\u4f53\u6e29\u306f**\u7d0436.5\u301c37.5\u2103**\u306e\u7bc4\u56f2\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u7bc4\u56f2\u3092\u8d85\u3048\u3066\u4f53\u6e29\u304c\u4e0a\u6607\uff08\u9ad8\u4f53\u6e29\u30fb\u767a\u71b1\uff09\u307e\u305f\u306f\u4f4e\u4e0b\uff08\u4f4e\u4f53\u6e29\uff09\u3059\u308b\u3068\u3001\u4f53\u306e\u6a5f\u80fd\u306b\u6df1\u523b\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f53\u6e29\u306f\u3001\u4e3b\u306b\u4ee5\u4e0b\u306e3\u3064\u306e\u65b9\u6cd5\u3067\u8abf\u7bc0\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u71b1\u7523\u751f<\/strong>\uff1a\u7b4b\u8089\u306e\u53ce\u7e2e\uff08\u9707\u3048\uff09\u3084\u4ee3\u8b1d\u6d3b\u52d5\u306b\u3088\u3063\u3066\u4f53\u71b1\u3092\u751f\u307f\u51fa\u3059\u3002<\/li>\n\n\n\n<li><strong>\u71b1\u653e\u6563<\/strong>\uff1a\u767a\u6c57\u3084\u76ae\u819a\u306e\u8840\u6d41\u8abf\u7bc0\u3092\u901a\u3058\u3066\u4f53\u71b1\u3092\u653e\u6563\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u884c\u52d5\u8abf\u7bc0<\/strong>\uff1a\u5bd2\u3044\u3068\u304d\u306b\u539a\u7740\u3092\u3059\u308b\u3001\u6691\u3044\u3068\u304d\u306b\u65e5\u9670\u306b\u5165\u308b\u306a\u3069\u306e\u884c\u52d5\u306b\u3088\u3063\u3066\u9069\u5fdc\u3059\u308b\u3002<\/li>\n<\/ol>\n\n\n\n<p>\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u5236\u5fa1\u3059\u308b\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u306e\u304c<strong>\u8996\u5e8a\u4e0b\u90e8<\/strong>\u3067\u3042\u308a\u3001\u3053\u3053\u306b\u306f\u4f53\u6e29\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u5b50\u304c\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9254\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29217899_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. TRP\u30c1\u30e3\u30cd\u30eb\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>TRP\uff08Transient Receptor Potential\uff09\u30c1\u30e3\u30cd\u30eb\u306f\u3001\u6e29\u5ea6\u5909\u5316\u3092\u611f\u77e5\u3059\u308b\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u74b0\u5883\u6e29\u5ea6\u306b\u5fdc\u3058\u305f\u751f\u7406\u7684\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>TRP\u30c1\u30e3\u30cd\u30eb<\/strong><\/td><td><strong>\u611f\u77e5\u3059\u308b\u6e29\u5ea6\u7bc4\u56f2<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><\/tr><tr><td>TRPV1<\/td><td>43\u2103\u4ee5\u4e0a\uff08\u9ad8\u6e29\uff09<\/td><td>\u71b1\u523a\u6fc0\u306e\u611f\u77e5\u3001\u75db\u899a\u3068\u306e\u95a2\u9023<\/td><\/tr><tr><td>TRPM8<\/td><td>25\u2103\u4ee5\u4e0b\uff08\u4f4e\u6e29\uff09<\/td><td>\u51b7\u611f\u306e\u611f\u77e5\u3001\u5bd2\u51b7\u523a\u6fc0\u3078\u306e\u9069\u5fdc<\/td><\/tr><tr><td>TRPA1<\/td><td>\u6975\u7aef\u306a\u51b7\u6e29\uff080\u2103\u4ee5\u4e0b\uff09<\/td><td>\u5bd2\u51b7\u523a\u6fc0\u306b\u3088\u308b\u75db\u899a\u5fdc\u7b54<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>TRPV1<\/strong>\u306f\u30ab\u30d7\u30b5\u30a4\u30b7\u30f3\uff08\u5510\u8f9b\u5b50\u306e\u8f9b\u307f\u6210\u5206\uff09\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u8f9b\u3044\u3082\u306e\u3092\u98df\u3079\u308b\u3068\u4f53\u6e29\u304c\u4e0a\u304c\u308b\u306e\u306f\u3053\u306e\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u306b\u3088\u308b\u3082\u306e\u3067\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2756323\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001<strong>TRPM8<\/strong>\u306f\u30df\u30f3\u30c8\u6210\u5206\uff08\u30e1\u30f3\u30c8\u30fc\u30eb\uff09\u306b\u53cd\u5fdc\u3057\u3001\u51b7\u611f\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u5bd2\u3055\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. UCP\uff08\u8131\u5171\u5f79\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>UCP\uff08Uncoupling Protein\uff09\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u3092\u8abf\u7bc0\u3057\u3001<strong>\u71b1\u7523\u751f<\/strong>\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u307e\u3059\u3002\u7279\u306b<strong>UCP1<\/strong>\u306f\u3001\u8910\u8272\u8102\u80aa\u7d44\u7e54\u306b\u304a\u3044\u3066\u71b1\u3092\u751f\u307f\u51fa\u3059\u5f79\u5272\u3092\u6301\u3061\u3001\u5bd2\u51b7\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>UCP\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u767a\u73fe\u90e8\u4f4d<\/strong><\/td><\/tr><tr><td>UCP1<\/td><td>\u975e\u3075\u308b\u3048\u71b1\u7523\u751f\u3092\u4fc3\u9032<\/td><td>\u8910\u8272\u8102\u80aa\u7d30\u80de<\/td><\/tr><tr><td>UCP2<\/td><td>\u4ee3\u8b1d\u8abf\u7bc0\u3001\u708e\u75c7\u5236\u5fa1<\/td><td>\u591a\u304f\u306e\u7d44\u7e54<\/td><\/tr><tr><td>UCP3<\/td><td>\u7b4b\u8089\u3067\u306e\u71b1\u7523\u751f<\/td><td>\u9aa8\u683c\u7b4b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>UCP1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u4eba<\/strong>\u306f\u3001\u5bd2\u51b7\u74b0\u5883\u3067\u3082\u4f53\u6e29\u3092\u7dad\u6301\u3057\u3084\u3059\u304f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u91cf\u304c\u591a\u3044\u305f\u3081\u592a\u308a\u306b\u304f\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u9006\u306bUCP1\u306e\u907a\u4f1d\u7684\u5909\u7570\u306b\u3088\u3063\u3066\u6d3b\u6027\u304c\u4f4e\u3044\u3068\u3001\u5bd2\u3055\u306b\u5f31\u304f\u306a\u308a\u3001\u80a5\u6e80\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2649-6\">nature.com<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. CLOCK\u907a\u4f1d\u5b50\u3068\u6982\u65e5\u30ea\u30ba\u30e0<\/strong><\/h3>\n\n\n\n<p>\u4f53\u6e29\u306f\u4e00\u65e5\u306e\u30ea\u30ba\u30e0\uff08\u6982\u65e5\u30ea\u30ba\u30e0\uff09\u306b\u5f93\u3063\u3066\u5909\u5316\u3057\u3001\u671d\u65b9\u306f\u4f4e\u304f\u3001\u5348\u5f8c\u306b\u304b\u3051\u3066\u4e0a\u6607\u3057\u3001\u591c\u9593\u306b\u518d\u3073\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u3053\u306e\u30ea\u30ba\u30e0\u306f<strong>CLOCK\u907a\u4f1d\u5b50<\/strong>\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>\u306f\u3001\u4f53\u6e29\u30ea\u30ba\u30e0\u306e\u4e71\u308c\u3060\u3051\u3067\u306a\u304f\u3001\u7761\u7720\u969c\u5bb3\u3084\u4ee3\u8b1d\u7570\u5e38\u3068\u3082\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u30b7\u30d5\u30c8\u30ef\u30fc\u30af\uff08\u591c\u52e4\uff09\u306e\u591a\u3044\u4eba\u3067\u306f\u3001CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u4f53\u6e29\u8abf\u7bc0\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u308a\u3084\u3059\u3044\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1389945719303153\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u8abf\u7bc0\u306b\u95a2\u9023\u3059\u308b\u75be\u60a3\u3068\u907a\u4f1d<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"700\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4822366_m-1024x700.jpg\" alt=\"\" class=\"wp-image-10108\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4822366_m-1024x700.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4822366_m-300x205.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4822366_m-768x525.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4822366_m-1536x1050.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4822366_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4f4e\u4f53\u6e29\u75c7\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u4f4e\u4f53\u6e29\u75c7\uff08Hypothermia\uff09\u306f\u3001\u4f53\u6e29\u304c35\u2103\u4ee5\u4e0b\u306b\u4f4e\u4e0b\u3059\u308b\u72b6\u614b\u3092\u6307\u3057\u3001<strong>UCP1\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u4f4e\u4e0b<\/strong>\u3084<strong>TRPM8\u306e\u611f\u53d7\u6027\u4f4e\u4e0b<\/strong>\u304c\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u5bd2\u51b7\u5730\u306b\u4f4f\u3080\u4eba\u3005\u306e\u9593\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u304c\u81ea\u7136\u9078\u629e\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u767a\u71b1\u306e\u500b\u4eba\u5dee<\/strong><\/h3>\n\n\n\n<p>\u98a8\u90aa\u3084\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306b\u304b\u304b\u3063\u305f\u969b\u306b\u767a\u71b1\u3057\u3084\u3059\u3044\u304b\u3069\u3046\u304b\u306f\u3001<strong>\u514d\u75ab\u5fdc\u7b54\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong>\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u767a\u71b1\u3068\u306e\u95a2\u9023<\/strong><\/td><\/tr><tr><td>IL6<\/td><td>\u514d\u75ab\u5fdc\u7b54\u306e\u8abf\u6574<\/td><td>IL6\u304c\u9ad8\u3044\u3068\u767a\u71b1\u3057\u3084\u3059\u3044<\/td><\/tr><tr><td>TNF\u03b1<\/td><td>\u708e\u75c7\u53cd\u5fdc\u306e\u4fc3\u9032<\/td><td>TNF\u03b1\u306e\u904e\u5270\u7523\u751f\u3067\u9ad8\u71b1\u304c\u51fa\u3084\u3059\u3044<\/td><\/tr><tr><td>PGE2<\/td><td>\u767a\u71b1\u306e\u8abf\u7bc0<\/td><td>PGE2\u304c\u9ad8\u3044\u3068\u89e3\u71b1\u3057\u306b\u304f\u3044<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001\u540c\u3058\u611f\u67d3\u75c7\u3067\u3082\u767a\u71b1\u306e\u7a0b\u5ea6\u306b\u500b\u4eba\u5dee\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3902171\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u8abf\u7bc0\u3068\u74b0\u5883\u9069\u5fdc\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9ad8\u6e29\u74b0\u5883\u3078\u306e\u9069\u5fdc\u3068\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u4eba\u9593\u306f\u9032\u5316\u306e\u904e\u7a0b\u3067\u7570\u306a\u308b\u6c17\u5019\u6761\u4ef6\u306b\u9069\u5fdc\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u305f\u907a\u4f1d\u7684\u5909\u7570\u304c\u84c4\u7a4d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001**\u6691\u71b1\u74b0\u5883\uff08\u9ad8\u6e29\u591a\u6e7f\u306a\u5730\u57df\uff09**\u3067\u306f\u3001\u4f53\u6e29\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u9078\u629e\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. HSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>HSP\uff08Heat Shock Proteins\uff09\u306f\u3001\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u640d\u50b7\u3092\u53d7\u3051\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4fee\u5fa9\u3057\u3001\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u5f79\u5272\u3092\u6301\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>HSP\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u9ad8\u6e29\u74b0\u5883\u3067\u306e\u9069\u5fdc<\/strong><\/td><\/tr><tr><td>HSP70<\/td><td>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u305f\u305f\u307f\u3068\u4fee\u5fa9<\/td><td>\u767a\u6c57\u306e\u4fc3\u9032\u3001\u71b1\u8010\u6027\u5411\u4e0a<\/td><\/tr><tr><td>HSP90<\/td><td>\u514d\u75ab\u5fdc\u7b54\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/td><td>\u9ad8\u6e29\u4e0b\u3067\u306e\u7d30\u80de\u4fdd\u8b77<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u7279\u306bHSP70\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3001\u9ad8\u6e29\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u305f\u3081\u306b\u81ea\u7136\u9078\u629e\u3092\u53d7\u3051\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30d5\u30ea\u30ab\u3084\u5357\u30a2\u30b8\u30a2\u306e\u4e00\u90e8\u306e\u6c11\u65cf\u3067\u306f\u3001HSP70\u306e\u767a\u73fe\u304c\u9ad8\u307e\u308a\u3001\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u5f37\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41598-018-19222-2\">nature.com<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. EDAR\u907a\u4f1d\u5b50\u3068\u6c57\u817a\u306e\u767a\u9054<\/strong><\/h4>\n\n\n\n<p>EDAR\uff08Ectodysplasin A receptor\uff09\u907a\u4f1d\u5b50\u306f\u3001\u76ae\u819a\u306e\u6c57\u817a\u3084\u6bdb\u9aea\u306e\u767a\u9054\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\uff08370A\uff09\u306f\u3001\u6771\u30a2\u30b8\u30a2\u3084\u30a2\u30e1\u30ea\u30ab\u5148\u4f4f\u6c11\u306b\u591a\u304f\u898b\u3089\u308c\u3001<strong>\u767a\u6c57\u80fd\u529b\u306e\u5411\u4e0a<\/strong>\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>EDAR\u5909\u7570<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u95a2\u9023\u3059\u308b\u9069\u5fdc<\/strong><\/td><\/tr><tr><td>370A<\/td><td>\u6c57\u817a\u306e\u6570\u304c\u5897\u52a0<\/td><td>\u9ad8\u6e29\u591a\u6e7f\u74b0\u5883\u3067\u306e\u71b1\u653e\u6563\u52b9\u7387\u5411\u4e0a<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>EDAR\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u3088\u308a\u591a\u304f\u306e\u6c57\u3092\u304b\u304f\u3053\u3068\u3067\u52b9\u7387\u7684\u306b\u4f53\u6e29\u3092\u4e0b\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u6691\u3044\u74b0\u5883\u3067\u306e\u751f\u5b58\u306b\u6709\u5229\u3060\u3063\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002929716302714\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5bd2\u51b7\u74b0\u5883\u3078\u306e\u9069\u5fdc\u3068\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u5bd2\u51b7\u74b0\u5883\u3067\u306f\u3001\u4f53\u6e29\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306e\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u5909\u7570\u304c\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. LEPR\u907a\u4f1d\u5b50\u3068\u8102\u80aa\u4ee3\u8b1d<\/strong><\/h4>\n\n\n\n<p>LEPR\uff08Leptin Receptor\uff09\u907a\u4f1d\u5b50\u306f\u3001\u8102\u80aa\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3057\u3001\u4f53\u6e29\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\u306f\u3001\u5bd2\u51b7\u5730\u306e\u6c11\u65cf\u306b\u591a\u304f\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>LEPR\u5909\u7570<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u95a2\u9023\u3059\u308b\u9069\u5fdc<\/strong><\/td><\/tr><tr><td>Arg109Lys<\/td><td>\u8102\u80aa\u84c4\u7a4d\u306e\u4fc3\u9032<\/td><td>\u4f4e\u6e29\u74b0\u5883\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4fdd\u6301<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u76ae\u4e0b\u8102\u80aa\u306e\u84c4\u7a4d\u304c\u5897\u52a0\u3057\u3001\u5bd2\u51b7\u74b0\u5883\u3067\u306e\u4f53\u6e29\u7dad\u6301\u304c\u5bb9\u6613\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5544383\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. UCP1\u907a\u4f1d\u5b50\u3068\u8910\u8272\u8102\u80aa<\/strong><\/h4>\n\n\n\n<p>\u8910\u8272\u8102\u80aa\u7d44\u7e54\uff08BAT\uff09\u306f\u3001\u71b1\u7523\u751f\u3092\u884c\u3046\u7279\u5225\u306a\u8102\u80aa\u7d44\u7e54\u3067\u3042\u308a\u3001\u5bd2\u51b7\u74b0\u5883\u3067\u306e\u9069\u5fdc\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u71b1\u7523\u751f\u3092\u5236\u5fa1\u3059\u308b\u306e\u304c**UCP1\uff08Uncoupling Protein 1\uff09**\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>UCP1\u5909\u7570<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u95a2\u9023\u3059\u308b\u9069\u5fdc<\/strong><\/td><\/tr><tr><td>-3826A\/G<\/td><td>\u8910\u8272\u8102\u80aa\u306e\u6d3b\u6027\u5411\u4e0a<\/td><td>\u4f4e\u6e29\u74b0\u5883\u3067\u306e\u71b1\u7523\u751f\u5897\u52a0<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u5bd2\u51b7\u5730\uff08\u4f8b\uff1a\u5317\u6b27\u3084\u30b7\u30d9\u30ea\u30a2\uff09\u306e\u4f4f\u6c11\u3067\u306f\u3001UCP1\u306e\u7279\u5b9a\u306e\u5909\u7570\u3092\u6301\u3064\u5272\u5408\u304c\u9ad8\u304f\u3001\u4f4e\u6e29\u4e0b\u3067\u3082\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u52b9\u7387\u3088\u304f\u71b1\u306b\u5909\u63db\u3067\u304d\u308b\u80fd\u529b\u304c\u9032\u5316\u7684\u306b\u7372\u5f97\u3055\u308c\u3066\u3044\u307e\u3059\u3002(genome.jp)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u8abf\u7bc0\u306e\u500b\u4eba\u5dee\u3068\u907a\u4f1d\u7684\u80cc\u666f<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/3290619_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9840\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3290619_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3290619_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3290619_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3290619_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3290619_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u57fa\u790e\u4f53\u6e29\u306e\u500b\u4eba\u5dee<\/strong><\/h3>\n\n\n\n<p>\u57fa\u790e\u4f53\u6e29\uff08\u5b89\u9759\u6642\u306e\u4f53\u6e29\uff09\u306f\u500b\u4eba\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u305d\u306e\u5dee\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u4f53\u6e29\u3078\u306e\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>THRA<\/td><td>\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u306e\u8abf\u7bc0<\/td><td>\u4ee3\u8b1d\u7387\u3068\u4f53\u6e29\u306e\u8abf\u7bc0<\/td><\/tr><tr><td>RORA<\/td><td>\u4f53\u5185\u6642\u8a08\u306e\u8abf\u7bc0<\/td><td>\u4f53\u6e29\u306e\u6982\u65e5\u30ea\u30ba\u30e0\u3078\u306e\u5f71\u97ff<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>THRA\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u57fa\u790e\u4ee3\u8b1d\u304c\u5909\u5316\u3057\u3001\u901a\u5e38\u3088\u308a\u9ad8\u3044\u307e\u305f\u306f\u4f4e\u3044\u4f53\u6e29\u3092\u6301\u3064\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23479631\/\">pubmed.ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u4f53\u6e29\u3068\u6027\u5dee<\/strong><\/h3>\n\n\n\n<p>\u6027\u5225\u306b\u3088\u3063\u3066\u3082\u4f53\u6e29\u8abf\u7bc0\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306b\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5973\u6027\u306f\u4e00\u822c\u7684\u306b<strong>\u76ae\u4e0b\u8102\u80aa\u304c\u591a\u304f<\/strong>\u3001\u71b1\u3092\u4fdd\u6301\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li>\u7537\u6027\u306f<strong>\u7b4b\u8089\u91cf\u304c\u591a\u304f<\/strong>\u3001\u71b1\u7523\u751f\u80fd\u529b\u304c\u9ad8\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3<\/strong>\uff08\u5973\u6027\u30db\u30eb\u30e2\u30f3\uff09\u304c\u4f53\u6e29\u8abf\u7bc0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\u3001<strong>\u6708\u7d4c\u5468\u671f\u306b\u3088\u3063\u3066\u4f53\u6e29\u304c\u5909\u52d5<\/strong>\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001PGR\uff08\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50\u306f\u3001\u5973\u6027\u306e\u4f53\u6e29\u8abf\u7bc0\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u6392\u5375\u5f8c\u306e\u9ad8\u6e29\u671f\u3092\u5f15\u304d\u8d77\u3053\u3059\u8981\u56e0\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0306453019300152\">sciencedirect.com<\/a>)<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u75c5\u6c17\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u767a\u71b1\u3057\u3084\u3059\u3044\u4eba\u3068\u3057\u306b\u304f\u3044\u4eba\u306e\u9055\u3044<\/strong><\/h3>\n\n\n\n<p>\u611f\u67d3\u75c7\u306b\u304b\u304b\u3063\u305f\u969b\u306e\u767a\u71b1\u306e\u3057\u3084\u3059\u3055\u306f\u3001<strong>\u514d\u75ab\u7cfb\u306e\u907a\u4f1d\u5b50<\/strong>\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>IL1B<\/td><td>\u708e\u75c7\u4fc3\u9032\u3001\u767a\u71b1\u306e\u5f37\u3055\u3092\u6c7a\u5b9a<\/td><\/tr><tr><td>TNF\u03b1<\/td><td>\u708e\u75c7\u53cd\u5fdc\u3092\u6d3b\u6027\u5316<\/td><\/tr><tr><td>PTGS2<\/td><td>\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u306e\u5408\u6210\u3092\u8abf\u6574<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u767a\u71b1\u3057\u3084\u3059\u3044\u4eba\u3068\u3057\u306b\u304f\u3044\u4eba\u304c\u5206\u304b\u308c\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7340271\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u4f4e\u4f53\u6e29\u75c7\u306b\u306a\u308a\u3084\u3059\u3044\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u5bd2\u51b7\u74b0\u5883\u306b\u5f31\u3044\u4eba\u306f\u3001UCP1\u3084LEPR\u306e\u907a\u4f1d\u7684\u5909\u7570\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306bUCP1\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u3068\u3001\u4f53\u6e29\u3092\u7dad\u6301\u3059\u308b\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u4f4e\u4f53\u6e29\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u8abf\u7bc0\u3068\u907a\u4f1d\u7684\u75be\u60a3<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/4373847_m-1024x683.jpg\" alt=\"\" class=\"wp-image-1114\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4373847_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4373847_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4373847_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4373847_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/4373847_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u5bb6\u65cf\u6027\u5bd2\u51b7\u81ea\u5df1\u708e\u75c7\u75c7\u5019\u7fa4\uff08FCAS\uff09<\/strong><\/h3>\n\n\n\n<p>\u5bb6\u65cf\u6027\u5bd2\u51b7\u81ea\u5df1\u708e\u75c7\u75c7\u5019\u7fa4\uff08FCAS\uff09\u306f\u3001\u5bd2\u51b7\u523a\u6fc0\u306b\u3088\u3063\u3066\u767a\u75c7\u3059\u308b\u81ea\u5df1\u708e\u75c7\u6027\u75be\u60a3\u3067\u3001<strong>NLRP3\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u304c\u539f\u56e0\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002NLRP3\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u5236\u5fa1\u3059\u308b\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\uff08\u708e\u75c7\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\uff09\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>NLRP3<\/td><td>\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316<\/td><td>\u5bd2\u51b7\u523a\u6fc0\u306b\u3088\u308b\u904e\u5270\u306a\u708e\u75c7\u53cd\u5fdc<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>FCAS\u60a3\u8005\u306f\u3001\u5bd2\u3055\u306b\u3055\u3089\u3055\u308c\u308b\u3068<strong>\u767a\u71b1\u3001\u95a2\u7bc0\u75db\u3001\u76ae\u819a\u767a\u75b9<\/strong>\u306a\u3069\u306e\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u3063\u3066\u708e\u75c7\u53cd\u5fdc\u304c\u5236\u5fa1\u3067\u304d\u306a\u304f\u306a\u308b\u305f\u3081\u3001\u4f4e\u6e29\u74b0\u5883\u3067\u5f37\u3044\u514d\u75ab\u5fdc\u7b54\u304c\u751f\u3058\u308b\u306e\u3067\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5709513\/\">nih.gov<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u7570\u5e38\u3068\u4f53\u6e29\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08T3\u3001T4\uff09\u306f\u3001\u57fa\u790e\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3057\u3001\u4f53\u6e29\u8abf\u7bc0\u306b\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\uff08\u30d0\u30bb\u30c9\u30a6\u75c5\uff09\u3068\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>\u30d0\u30bb\u30c9\u30a6\u75c5\u306f\u3001<strong>TSHR\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u7532\u72b6\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08TSH\uff09\u53d7\u5bb9\u4f53\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u904e\u5270\u306a\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u4e3b\u306a\u75c7\u72b6<\/strong><\/td><\/tr><tr><td>TSHR<\/td><td>\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u5897\u52a0<\/td><td>\u767a\u6c57\u3001\u52d5\u60b8\u3001\u4f53\u6e29\u4e0a\u6607<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u30d0\u30bb\u30c9\u30a6\u75c5\u306e\u60a3\u8005\u306f<strong>\u4f53\u6e29\u304c\u9ad8\u304f\u3001\u6c57\u3092\u304b\u304d\u3084\u3059\u3044<\/strong>\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925820303498\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\uff08\u6a4b\u672c\u75c5\uff09\u3068\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>\u6a4b\u672c\u75c5\u306f\u3001<strong>TPO\u907a\u4f1d\u5b50<\/strong>\u306e\u7570\u5e38\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001\u57fa\u790e\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u4e3b\u306a\u75c7\u72b6<\/strong><\/td><\/tr><tr><td>TPO<\/td><td>\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5408\u6210\u4f4e\u4e0b<\/td><td>\u51b7\u3048\u6027\u3001\u75b2\u52b4\u611f\u3001\u4f4e\u4f53\u6e29<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u6a4b\u672c\u75c5\u306e\u60a3\u8005\u306f\u3001\u4e00\u822c\u7684\u306b<strong>\u4f53\u6e29\u304c\u4f4e\u304f\u3001\u5bd2\u3055\u306b\u5f31\u3044<\/strong>\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7074180\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/3881852_m-1024x683.jpg\" alt=\"\u30de\u30e9\u30bd\u30f3\" class=\"wp-image-2975\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3881852_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3881852_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3881852_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3881852_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/3881852_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u4f53\u6e29\u8abf\u7bc0\u306b\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u4ed5\u7d44\u307f\u304c\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u304c\u3001\u71b1\u7523\u751f\u3084\u4f53\u6e29\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff08mtDNA\uff09\u3068\u4f53\u6e29\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u3001\u7d30\u80de\u5185\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\uff08ATP\uff09\u3092\u7523\u751f\u3059\u308b\u91cd\u8981\u306a\u5668\u5b98\u3067\u3042\u308a\u3001\u305d\u306e\u6a5f\u80fd\u306f**mtDNA\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff09**\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>mtDNA\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u4f53\u6e29\u8abf\u7bc0\u3078\u306e\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>ND1<\/td><td>\u96fb\u5b50\u4f1d\u9054\u7cfb\u306e\u8abf\u7bc0<\/td><td>ATP\u7523\u751f\u52b9\u7387\u3068\u71b1\u7523\u751f\u306b\u95a2\u4e0e<\/td><\/tr><tr><td>COX1<\/td><td>\u9178\u7d20\u5229\u7528\u306e\u8abf\u6574<\/td><td>\u4ee3\u8b1d\u7387\u306e\u8abf\u7bc0<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u7279\u5b9a\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001<strong>\u4ee3\u8b1d\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u4f53\u6e29\u304c\u4f4e\u304f\u306a\u308b<\/strong>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(genome.jp)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. PGC-1\u03b1\u907a\u4f1d\u5b50\u3068\u904b\u52d5\u306b\u3088\u308b\u4f53\u6e29\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>PGC-1\u03b1\uff08Peroxisome proliferator-activated receptor gamma coactivator 1-alpha\uff09\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u751f\u6210\u3068\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\u3001\u904b\u52d5\u306b\u3088\u308b\u4f53\u6e29\u8abf\u7bc0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u904b\u52d5\u6642\u306e\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>PGC-1\u03b1<\/td><td>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5897\u52a0<\/td><td>\u71b1\u7523\u751f\u306e\u4fc3\u9032<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u9ad8\u3044\u3068\u3001\u904b\u52d5\u6642\u306b\u52b9\u7387\u3088\u304f\u71b1\u3092\u7523\u751f\u3057\u3001\u4f53\u6e29\u3092\u7dad\u6301\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u9006\u306b\u3001\u767a\u73fe\u304c\u4f4e\u3044\u3068\u3001\u904b\u52d5\u6642\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u304c\u4f4e\u4e0b\u3057\u3001\u5bd2\u51b7\u74b0\u5883\u3067\u306e\u8010\u6027\u304c\u5f31\u304f\u306a\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6352106\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u85ac\u7269\u306e\u4f53\u6e29\u3078\u306e\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-1024x683.jpg\" alt=\"\u85ac\u3068\u6c34\" class=\"wp-image-8601\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31831804_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u85ac\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306b\u3082\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u89e3\u71b1\u93ae\u75db\u5264\u3084\u8208\u596e\u5264\u306e\u5f71\u97ff\u306f\u3001\u4ee3\u8b1d\u9175\u7d20\u306e\u907a\u4f1d\u7684\u591a\u578b\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. CYP2C9\u907a\u4f1d\u5b50\u3068\u89e3\u71b1\u93ae\u75db\u5264\u306e\u4ee3\u8b1d<\/strong><\/h3>\n\n\n\n<p>CYP2C9\u306f\u3001<strong>\u30a4\u30d6\u30d7\u30ed\u30d5\u30a7\u30f3\u3084\u30a2\u30b9\u30d4\u30ea\u30f3<\/strong>\u306a\u3069\u306e\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac\uff08NSAIDs\uff09\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50\u5909\u7570<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u85ac\u7269\u306e\u52b9\u679c<\/strong><\/td><\/tr><tr><td>CYP2C9*2<\/td><td>\u4ee3\u8b1d\u9045\u5ef6<\/td><td>\u52b9\u679c\u304c\u9577\u7d9a\u304d\u3059\u308b\u304c\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u5897\u52a0<\/td><\/tr><tr><td>CYP2C9*3<\/td><td>\u4ee3\u8b1d\u80fd\u529b\u4f4e\u4e0b<\/td><td>\u85ac\u306e\u84c4\u7a4d\u306b\u3088\u308b\u526f\u4f5c\u7528\u5897\u52a0<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>CYP2C9\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u89e3\u71b1\u5264\u306e\u52b9\u679c\u304c\u5f37\u304f\u51fa\u305f\u308a\u3001\u526f\u4f5c\u7528\u304c\u51fa\u3084\u3059\u304f\u306a\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u6295\u4e0e\u91cf\u306e\u8abf\u6574\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002(fda.gov)<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. COMT\u907a\u4f1d\u5b50\u3068\u30ab\u30d5\u30a7\u30a4\u30f3\u611f\u53d7\u6027<\/strong><\/h3>\n\n\n\n<p>\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u4ea4\u611f\u795e\u7d4c\u3092\u523a\u6fc0\u3057\u3001\u4f53\u6e29\u3092\u4e00\u6642\u7684\u306b\u4e0a\u6607\u3055\u305b\u308b\u4f5c\u7528\u3092\u6301\u3061\u307e\u3059\u3002\u3053\u306e\u4ee3\u8b1d\u306b\u306f\u3001<strong>COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong>\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50\u5909\u7570<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><td><strong>\u30ab\u30d5\u30a7\u30a4\u30f3\u611f\u53d7\u6027<\/strong><\/td><\/tr><tr><td>COMT Val\/Val<\/td><td>\u4ee3\u8b1d\u304c\u901f\u3044<\/td><td>\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u306b\u304f\u3044<\/td><\/tr><tr><td>COMT Met\/Met<\/td><td>\u4ee3\u8b1d\u304c\u9045\u3044<\/td><td>\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>COMT\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u6442\u53d6\u5f8c\u306e\u4f53\u6e29\u4e0a\u6607\u306e\u7a0b\u5ea6\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(journals.plos.org)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u5bd2\u51b7\u8010\u6027\u306e\u9032\u5316\u7684\u9069\u5fdc<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30a4\u30cc\u30a4\u30c3\u30c8\u306e\u907a\u4f1d\u7684\u9069\u5fdc<\/strong><\/h3>\n\n\n\n<p>\u5bd2\u51b7\u5730\u306b\u4f4f\u3080\u30a4\u30cc\u30a4\u30c3\u30c8\u306e\u4eba\u3005\u306f\u3001\u6975\u7aef\u306a\u4f4e\u6e29\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u305f\u3081\u306e\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>\u8102\u80aa\u4ee3\u8b1d\u3068\u71b1\u7523\u751f\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong>\u304c\u9078\u629e\u7684\u306b\u9032\u5316\u3057\u305f\u3053\u3068\u304c\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30a4\u30cc\u30a4\u30c3\u30c8\u306b\u7279\u6709\u306e\u907a\u4f1d\u5b50\u5909\u7570<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u9069\u5fdc\u306e\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>TBX15<\/td><td>\u76ae\u4e0b\u8102\u80aa\u306e\u5206\u5e03\u8abf\u6574<\/td><td>\u672b\u68a2\u306e\u71b1\u640d\u5931\u3092\u9632\u3050<\/td><\/tr><tr><td>WARS2<\/td><td>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u8abf\u6574<\/td><td>\u4f53\u6e29\u7dad\u6301\u306e\u305f\u3081\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u52b9\u7387\u5411\u4e0a<\/td><\/tr><tr><td>CPT1A<\/td><td>\u8102\u80aa\u9178\u306e\u9178\u5316\u4fc3\u9032<\/td><td>\u8102\u80aa\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u5229\u7528\u3057\u3084\u3059\u304f\u3059\u308b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>TBX15\u907a\u4f1d\u5b50<\/strong>\u306e\u5909\u7570\u306f\u3001<strong>\u624b\u8db3\u306e\u76ae\u4e0b\u8102\u80aa\u306e\u5206\u5e03\u3092\u5909\u3048\u308b<\/strong>\u3053\u3068\u3067\u71b1\u640d\u5931\u3092\u6700\u5c0f\u9650\u306b\u3057\u3001\u4f4e\u6e29\u74b0\u5883\u4e0b\u3067\u3082\u4f53\u6e29\u3092\u7dad\u6301\u3057\u3084\u3059\u304f\u306a\u308b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/ncomms9805\">nature.com<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30b7\u30d9\u30ea\u30a2\u5148\u4f4f\u6c11\u306e\u5bd2\u51b7\u9069\u5fdc<\/strong><\/h3>\n\n\n\n<p>\u30b7\u30d9\u30ea\u30a2\u5148\u4f4f\u6c11\u3082\u307e\u305f\u3001\u5bd2\u51b7\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u305f\u3081\u306e\u907a\u4f1d\u7684\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>UCP1\u3068\u95a2\u9023\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u907a\u4f1d\u5b50<\/strong>\u304c\u3001\u5bd2\u3055\u3078\u306e\u8010\u6027\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b7\u30d9\u30ea\u30a2\u5148\u4f4f\u6c11\u306b\u898b\u3089\u308c\u308b\u907a\u4f1d\u7684\u9069\u5fdc<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u9069\u5fdc\u306e\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>PRDM16<\/td><td>\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u5206\u5316\u8abf\u7bc0<\/td><td>\u71b1\u7523\u751f\u3092\u4fc3\u9032<\/td><\/tr><tr><td>ADRB3<\/td><td>\u03b23\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u8abf\u6574<\/td><td>\u8102\u80aa\u71c3\u713c\u3092\u4fc3\u9032\u3057\u3001\u4f53\u6e29\u7dad\u6301<\/td><\/tr><tr><td>LEPR<\/td><td>\u30ec\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\u306e\u8abf\u7bc0<\/td><td>\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u6700\u9069\u5316<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>PRDM16\u306f\u3001\u8910\u8272\u8102\u80aa\u7d44\u7e54\uff08BAT\uff09\u306e\u767a\u9054\u3092\u4fc3\u3057\u3001\u5bd2\u51b7\u74b0\u5883\u4e0b\u3067\u3082\u52b9\u7387\u7684\u306b\u4f53\u6e29\u3092\u7dad\u6301\u3067\u304d\u308b\u3088\u3046\u306b\u50cd\u304d\u307e\u3059\u3002(cell.com)<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u71b1\u4e2d\u75c7\u306e\u30ea\u30b9\u30af<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31193193_m-1024x683.jpg\" alt=\"\" class=\"wp-image-10257\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31193193_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31193193_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31193193_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31193193_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31193193_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u71b1\u4e2d\u75c7\u306e\u611f\u53d7\u6027\u3068\u907a\u4f1d<\/strong><\/h3>\n\n\n\n<p>\u71b1\u4e2d\u75c7\u306b\u304b\u304b\u308a\u3084\u3059\u3044\u304b\u3069\u3046\u304b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>\u8840\u6db2\u5faa\u74b0\u3001\u6c57\u306e\u8abf\u7bc0\u3001\u708e\u75c7\u53cd\u5fdc\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong>\u304c\u3001\u71b1\u4e2d\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u71b1\u4e2d\u75c7\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u71b1\u4e2d\u75c7\u30ea\u30b9\u30af\u3078\u306e\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>HSP70<\/td><td>\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\u306e\u7523\u751f<\/td><td>HSP70\u306e\u767a\u73fe\u304c\u4f4e\u3044\u3068\u71b1\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u4e0b<\/td><\/tr><tr><td>ACE<\/td><td>\u8840\u7ba1\u306e\u53ce\u7e2e\u30fb\u62e1\u5f35\u8abf\u6574<\/td><td>ACE\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3067\u8840\u5727\u8abf\u6574\u80fd\u529b\u304c\u7570\u306a\u308b<\/td><\/tr><tr><td>NPPA<\/td><td>\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9\u306e\u8abf\u7bc0<\/td><td>\u4f53\u6db2\u30d0\u30e9\u30f3\u30b9\u306e\u8abf\u6574\u3001\u8131\u6c34\u9632\u6b62<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>HSP70\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba\u306f\u3001\u71b1\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u7d30\u80de\u640d\u50b7\u304b\u3089\u306e\u56de\u5fa9\u304c\u901f\u304f\u3001\u71b1\u4e2d\u75c7\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u5f37\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002(journals.physiology.org)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u6c57\u306e\u5206\u6ccc\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u6c57\u3092\u304b\u304d\u3084\u3059\u3044\u304b\u3069\u3046\u304b\u3082\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u7279\u306b\u3001<strong>\u6c57\u817a\u306e\u767a\u9054\u3084\u6c34\u5206\u30d0\u30e9\u30f3\u30b9\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong>\u304c\u3001\u767a\u6c57\u80fd\u529b\u3092\u6c7a\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u767a\u6c57\u80fd\u529b\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u767a\u6c57\u80fd\u529b\u3078\u306e\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>AQP5<\/td><td>\u6c34\u30c1\u30e3\u30cd\u30eb\u306e\u8abf\u7bc0<\/td><td>AQP5\u306e\u767a\u73fe\u304c\u9ad8\u3044\u3068\u767a\u6c57\u80fd\u529b\u304c\u5411\u4e0a<\/td><\/tr><tr><td>EDAR<\/td><td>\u6c57\u817a\u306e\u767a\u9054\u8abf\u7bc0<\/td><td>EDAR\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u6c57\u817a\u306e\u6570\u304c\u5897\u52a0<\/td><\/tr><tr><td>CFTR<\/td><td>\u5869\u5206\u30d0\u30e9\u30f3\u30b9\u306e\u8abf\u6574<\/td><td>CFTR\u306e\u7570\u5e38\u3067\u5869\u5206\u55aa\u5931\u304c\u5897\u52a0\u3057\u3084\u3059\u3044<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>EDAR\u306e\u7279\u5b9a\u306e\u5909\u7570\u3092\u6301\u3064\u6771\u30a2\u30b8\u30a2\u7cfb\u306e\u4eba\u3005\u306f\u3001\u6c57\u817a\u306e\u6570\u304c\u591a\u304f\u3001\u6691\u71b1\u74b0\u5883\u3067\u3082\u52b9\u7387\u3088\u304f\u4f53\u6e29\u3092\u4e0b\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002929716302714\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u4f53\u6e29\u8abf\u7bc0\u306e\u500b\u5225\u5316\u533b\u7642<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u5065\u5eb7\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u4f53\u6e29\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u7684\u7279\u5fb4\u3092\u8abf\u3079\u3001\u500b\u5225\u5316\u533b\u7642\u306b\u5fdc\u7528\u3059\u308b\u8a66\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u5206\u304b\u308b\u3053\u3068<\/strong><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u71b1\u4e2d\u75c7\u3084\u5bd2\u51b7\u9069\u5fdc\u306e\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/li>\n\n\n\n<li><strong>\u6700\u9069\u306a\u904b\u52d5\u30fb\u30c0\u30a4\u30a8\u30c3\u30c8\u30d7\u30e9\u30f3\u306e\u63d0\u6848<\/strong>\uff08UCP1\u907a\u4f1d\u5b50\u306e\u767a\u73fe\uff09<\/li>\n\n\n\n<li><strong>\u9069\u5207\u306a\u6c34\u5206\u30fb\u96fb\u89e3\u8cea\u6442\u53d6\u91cf\u306e\u63a8\u5968<\/strong>\uff08NPPA\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff09<\/li>\n<\/ol>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001UCP1\u306e\u767a\u73fe\u304c\u4f4e\u3044\u4eba\u306f\u3001\u5bd2\u51b7\u74b0\u5883\u3067\u306e\u904b\u52d5\u6642\u306b\u7279\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u9069\u5207\u306a\u9632\u5bd2\u5bfe\u7b56\u3092\u884c\u3046\u3053\u3068\u3067\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u307e\u3059\u3002(<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/scientists-use-crispr-correct-genetic-mutation-mice\">nih.gov<\/a>)<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u4f53\u6e29\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>CRISPR-Cas9\u306a\u3069\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u4f53\u6e29\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3057\u3001\u5bd2\u51b7\u9069\u5fdc\u3084\u71b1\u4e2d\u75c7\u8010\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u53ef\u80fd\u306a\u907a\u4f1d\u5b50\u7de8\u96c6\u306e\u5fdc\u7528\u4f8b<\/strong><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>UCP1\u306e\u6d3b\u6027\u3092\u5897\u5f37\u3057\u3001\u5bd2\u51b7\u9069\u5fdc\u3092\u5411\u4e0a<\/strong><\/li>\n\n\n\n<li><strong>HSP70\u306e\u767a\u73fe\u3092\u9ad8\u3081\u3001\u71b1\u4e2d\u75c7\u8010\u6027\u3092\u5411\u4e0a<\/strong><\/li>\n\n\n\n<li><strong>EDAR\u907a\u4f1d\u5b50\u3092\u8abf\u6574\u3057\u3001\u767a\u6c57\u80fd\u529b\u3092\u6700\u9069\u5316<\/strong><\/li>\n<\/ol>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u307e\u3060\u521d\u671f\u6bb5\u968e\u3067\u3059\u304c\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u304c\u9032\u6b69\u3059\u308b\u3053\u3068\u3067\u3001\u5c06\u6765\u7684\u306b\u306f\u74b0\u5883\u9069\u5fdc\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002(sciencemag.org)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u8abf\u7bc0\u3068\u7761\u7720\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/30195756_m-1024x574.jpg\" alt=\"\" class=\"wp-image-1774\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30195756_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30195756_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30195756_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30195756_m-1536x861.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30195756_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u4f53\u6e29\u30ea\u30ba\u30e0\u3068\u907a\u4f1d<\/strong><\/h3>\n\n\n\n<p>\u4eba\u9593\u306e\u4f53\u6e29\u306f\u3001\u6982\u65e5\u30ea\u30ba\u30e0\uff08\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\uff09\u306b\u5f93\u3063\u3066\u5909\u5316\u3057\u3001<strong>\u65e5\u4e2d\u306b\u9ad8\u304f\u3001\u591c\u9593\u306b\u4f4e\u304f<\/strong>\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30ea\u30ba\u30e0\u3092\u8abf\u7bc0\u3059\u308b\u4e3b\u306a\u907a\u4f1d\u5b50\u304c\u3001<strong>CLOCK\u907a\u4f1d\u5b50\u7fa4<\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u4f53\u6e29\u30ea\u30ba\u30e0\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>CLOCK<\/td><td>\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u8abf\u6574<\/td><td>\u7761\u7720\u30fb\u899a\u9192\u30b5\u30a4\u30af\u30eb\u306e\u7dad\u6301<\/td><\/tr><tr><td>PER2<\/td><td>\u4f53\u6e29\u306e\u65e5\u5185\u5909\u52d5\u306e\u5236\u5fa1<\/td><td>\u5909\u7570\u306b\u3088\u308a\u4f53\u6e29\u30ea\u30ba\u30e0\u304c\u5d29\u308c\u308b<\/td><\/tr><tr><td>BMAL1<\/td><td>\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u306e\u8abf\u6574<\/td><td>\u7761\u7720\u306e\u8cea\u306b\u5f71\u97ff<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001<strong>\u4f53\u6e29\u30ea\u30ba\u30e0\u304c\u4e71\u308c\u3001\u4e0d\u7720\u75c7\u3084\u6982\u65e5\u30ea\u30ba\u30e0\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u3044<\/strong>\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1389945719303153\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u7761\u7720\u6642\u306e\u4f53\u6e29\u8abf\u7bc0<\/strong><\/h3>\n\n\n\n<p>\u7761\u7720\u4e2d\u306e\u4f53\u6e29\u8abf\u7bc0\u306f\u3001\u6df1\u90e8\u4f53\u6e29\uff08\u5185\u81d3\u3084\u8133\u306e\u6e29\u5ea6\uff09\u3068\u76ae\u819a\u6e29\u5ea6\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u3088\u3063\u3066\u6c7a\u307e\u308a\u307e\u3059\u3002\u7279\u306b\u3001**\u30e1\u30e9\u30c8\u30cb\u30f3\uff08\u7761\u7720\u30db\u30eb\u30e2\u30f3\uff09**\u306e\u5206\u6ccc\u304c\u3001\u4f53\u6e29\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u30b9\u30e0\u30fc\u30ba\u306a\u5165\u7720\u3092\u52a9\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u304c\u4f4e\u3044<\/strong> \u2192 \u4f53\u6e29\u304c\u5341\u5206\u306b\u4f4e\u4e0b\u305b\u305a\u3001\u4e0d\u7720\u306b\u306a\u308a\u3084\u3059\u3044<\/li>\n\n\n\n<li><strong>\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc\u304c\u9ad8\u3044<\/strong> \u2192 \u4f53\u6e29\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u7720\u308a\u304c\u6df1\u304f\u306a\u308b<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u4e0e\u3059\u308b\u306e\u304c\u3001<strong>MTNR1B\u907a\u4f1d\u5b50<\/strong>\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001<strong>\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u304c\u4e0d\u5b89\u5b9a\u306b\u306a\u308a\u3001\u4f53\u6e29\u8abf\u7bc0\u3068\u7761\u7720\u30ea\u30ba\u30e0\u304c\u4e71\u308c\u3084\u3059\u304f\u306a\u308b<\/strong>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4005694\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u51b7\u3048\u6027\u3068\u7761\u7720\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u51b7\u3048\u6027\u306e\u4eba\u306f\u3001\u672b\u7aef\u306e\u8840\u6d41\u304c\u60aa\u3044\u305f\u3081\u3001<strong>\u76ae\u819a\u6e29\u5ea6\u304c\u5341\u5206\u306b\u4e0a\u6607\u305b\u305a\u3001\u5bdd\u3064\u304d\u304c\u60aa\u304f\u306a\u308b<\/strong>\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u73fe\u8c61\u306b\u306f\u3001**NOS3\uff08\u8840\u7ba1\u62e1\u5f35\u3092\u4fc3\u3059\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\uff09**\u306e\u907a\u4f1d\u7684\u5909\u7570\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u907a\u4f1d\u5b50<\/strong><\/td><td><strong>\u5f79\u5272<\/strong><\/td><td><strong>\u5f71\u97ff<\/strong><\/td><\/tr><tr><td>NOS3<\/td><td>\u8840\u7ba1\u62e1\u5f35\u306e\u4fc3\u9032<\/td><td>\u5909\u7570\u304c\u3042\u308b\u3068\u8840\u6d41\u304c\u60aa\u5316\u3057\u3001\u51b7\u3048\u6027\u304c\u5f37\u307e\u308b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>NOS3\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u8840\u6d41\u304c\u6ede\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u5bdd\u308b\u524d\u306b<strong>\u6e29\u304b\u3044\u98f2\u307f\u7269\u3084\u5165\u6d74\u3092\u3057\u3066\u4f53\u6e29\u3092\u4e0a\u3052\u308b\u3068\u3001\u5feb\u7720\u306b\u3064\u306a\u304c\u308a\u3084\u3059\u3044<\/strong>\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002(journals.physiology.org)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h2>\n\n\n\n<p>\u4f53\u6e29\u8abf\u7bc0\u306f\u3001TRP\u30c1\u30e3\u30cd\u30eb\u3084UCP1\u3001CLOCK\u907a\u4f1d\u5b50\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5bd2\u51b7\u74b0\u5883\u3084\u6691\u71b1\u74b0\u5883\u3078\u306e\u9069\u5fdc\u3001\u767a\u71b1\u3084\u4f4e\u4f53\u6e29\u75c7\u306e\u500b\u4eba\u5dee\u3001\u7761\u7720\u306e\u8cea\u3084\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u8abf\u6574\u306b\u3082\u907a\u4f1d\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3084\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u4f53\u6e29\u8abf\u7bc0\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u7279\u5fb4\u3092\u500b\u5225\u306b\u89e3\u6790\u3057\u3001\u9069\u5207\u306a\u5065\u5eb7\u7ba1\u7406\u3084\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u81ea\u5206\u306e\u4f53\u8cea\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u306b\u5408\u3063\u305f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u3001\u5065\u5eb7\u7dad\u6301\u306b\u5f79\u7acb\u3064\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u7c21\u5358\u30fb\u5b89\u5fc3\uff01<br \/><span>\u8ff7\u308f\u305a\u59cb\u3081\u308b\u305f\u3081\u306b<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u306f\u3058\u3081\u306b \u4f53\u6e29\u306f\u751f\u547d\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u8981\u7d20\u3067\u3042\u308a\u3001\u79c1\u305f\u3061\u306e\u4f53\u306f\u5916\u90e8\u74b0\u5883\u306e\u5909\u5316\u306b\u9069\u5fdc\u3057\u306a\u304c\u3089\u4f53\u6e29\u3092\u4e00\u5b9a\u306b\u4fdd\u3064\u4ed5\u7d44\u307f\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4f53\u6e29\u8abf\u7bc0\u6a5f\u80fd\u306f\u3001\u795e\u7d4c\u7cfb\u3084\u30db\u30eb\u30e2\u30f3\u7cfb\u306e\u50cd\u304d\u306b\u52a0\u3048\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002 \u6700 [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":10250,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,1],"tags":[52,40,41,53,59,36,49,34,45,55],"class_list":["post-10248","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-basicknowledge","category-latest-technology","tag-dna-test","tag-privacy","tag-personalized-medicine","tag-parent-child-relationship","tag-59","tag-gene-testing","tag-gene-analysis","tag-genetic-identification","tag-genetics","tag-genetic-diseases"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=10248"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10248\/revisions"}],"predecessor-version":[{"id":10264,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10248\/revisions\/10264"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/10250"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=10248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=10248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=10248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}