{"id":10265,"date":"2025-03-19T02:36:02","date_gmt":"2025-03-19T02:36:02","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10265"},"modified":"2025-03-19T02:36:07","modified_gmt":"2025-03-19T02:36:07","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3d%e5%90%b8%e5%8f%8e%ef%bc%9a%e3%82%b5%e3%83%97%e3%83%aa%e9%81%b8%e3%81%b3%e3%81%ae%e5%9f%ba%e6%ba%96","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3d%e5%90%b8%e5%8f%8e%ef%bc%9a%e3%82%b5%e3%83%97%e3%83%aa%e9%81%b8%e3%81%b3%e3%81%ae%e5%9f%ba%e6%ba%96\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u30d3\u30bf\u30df\u30f3D\u5438\u53ce\uff1a\u30b5\u30d7\u30ea\u9078\u3073\u306e\u57fa\u6e96"},"content":{"rendered":"\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u9aa8\u306e\u5065\u5eb7\u3084\u514d\u75ab\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u6804\u990a\u7d20\u3067\u3059\u304c\u3001\u305d\u306e\u5438\u53ce\u3084\u5229\u7528\u52b9\u7387\u306b\u306f<strong>\u907a\u4f1d\u7684\u8981\u56e0<\/strong>\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u3084\u5438\u53ce\u306b\u95a2\u308f\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5fc5\u8981\u91cf\u3084\u52b9\u679c\u306b\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001<strong>\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u3001\u4e3b\u8981\u306a\u95a2\u9023\u907a\u4f1d\u5b50\u3001\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u9078\u3073\u306e\u30dd\u30a4\u30f3\u30c8<\/strong>\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002\u79d1\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u6226\u7565\u3092\u77e5\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u5065\u5eb7\u7ba1\u7406\u3092\u5b9f\u8df5\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u30d3\u30bf\u30df\u30f3D\u306e\u5f79\u5272\u3068\u4ee3\u8b1d\u30d7\u30ed\u30bb\u30b9<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.1 \u30d3\u30bf\u30df\u30f3D\u306e\u751f\u7406\u7684\u5f79\u5272<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u91cd\u8981\u306a\u6a5f\u80fd\u3092\u679c\u305f\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nrendo.2017.104\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9aa8\u306e\u5065\u5eb7\u7dad\u6301<\/strong>\uff1a\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u3092\u4fc3\u9032\u3057\u3001\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u514d\u75ab\u6a5f\u80fd\u306e\u8abf\u6574<\/strong>\uff1a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u3002<\/li>\n\n\n\n<li><strong>\u6297\u708e\u75c7\u4f5c\u7528<\/strong>\uff1a\u6162\u6027\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u5065\u5eb7\u3092\u30b5\u30dd\u30fc\u30c8\u3002<\/li>\n\n\n\n<li><strong>\u7b4b\u8089\u6a5f\u80fd\u306e\u7dad\u6301<\/strong>\uff1a\u7b4b\u529b\u4f4e\u4e0b\u3092\u9632\u304e\u3001\u904b\u52d5\u80fd\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u98df\u4e8b\u304b\u3089\u6442\u53d6\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u7d2b\u5916\u7dda\uff08UVB\uff09\u3092\u6d74\u3073\u308b\u3053\u3068\u3067\u76ae\u819a\u3067\u5408\u6210<\/strong> \u3055\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u500b\u3005\u306e\u4f53\u5185\u3067\u306e\u5438\u53ce\u3084\u6d3b\u6027\u5316\u306e\u52b9\u7387\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1.2 \u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u30d7\u30ed\u30bb\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u306f\u3001\u4ee5\u4e0b\u306e3\u3064\u306e\u30b9\u30c6\u30c3\u30d7\u3067\u9032\u884c\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4047306\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u6442\u53d6\u30fb\u5408\u6210<\/strong>\uff1a\u7d2b\u5916\u7dda\u3092\u6d74\u3073\u308b\u3053\u3068\u3067\u76ae\u819a\u3067\u30d3\u30bf\u30df\u30f3D3\uff08\u30b3\u30ec\u30ab\u30eb\u30b7\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u304c\u751f\u6210\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304b\u3089D2\uff08\u30a8\u30eb\u30b4\u30ab\u30eb\u30b7\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u307e\u305f\u306fD3\u3092\u6442\u53d6\u3002<\/li>\n\n\n\n<li><strong>\u809d\u81d3\u3067\u306e\u5909\u63db<\/strong>\uff1a\u809d\u81d3\u306e\u9175\u7d20 <strong>CYP2R1<\/strong> \u306b\u3088\u3063\u3066 <strong>25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\uff0825(OH)D\uff09<\/strong> \u306b\u5909\u63db\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u814e\u81d3\u3067\u306e\u6d3b\u6027\u5316<\/strong>\uff1a\u814e\u81d3\u306e <strong>CYP27B1<\/strong> \u9175\u7d20\u304c <strong>1,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\uff081,25(OH)\u2082D\uff09<\/strong> \u306b\u5909\u63db\u3057\u3001\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3068\u3057\u3066\u6a5f\u80fd\u3092\u679c\u305f\u3059\u3002<\/li>\n<\/ol>\n\n\n\n<p>\u3053\u306e\u4ee3\u8b1d\u7d4c\u8def\u306e\u3069\u3053\u304b\u306b\u907a\u4f1d\u7684\u306a\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3084\u5229\u7528\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u30d3\u30bf\u30df\u30f3D\u5438\u53ce\u306b\u95a2\u308f\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.1 VDR\u907a\u4f1d\u5b50\uff08\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff09<\/strong><\/h3>\n\n\n\n<p><strong>VDR\uff08Vitamin D Receptor\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u7d30\u80de\u5185\u3067\u306e\u50cd\u304d\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002VDR\u304c\u5341\u5206\u306b\u6a5f\u80fd\u3057\u306a\u3044\u3068\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u9069\u5207\u306b\u4f5c\u7528\u305b\u305a\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u304c\u4f4e\u4e0b\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ejcn2014254\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FokI\u591a\u578b\uff08rs2228570\uff09<\/strong>\uff1aF\u578b\u3092\u6301\u3064\u4eba\u306f\u30d3\u30bf\u30df\u30f3D\u306e\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001ff\u578b\u306e\u4eba\u306f\u611f\u53d7\u6027\u304c\u4f4e\u3044\u3002<\/li>\n\n\n\n<li><strong>TaqI\u591a\u578b\uff08rs731236\uff09<\/strong>\uff1aTT\u578b\u3092\u6301\u3064\u4eba\u306f\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>BsmI\u591a\u578b\uff08rs1544410\uff09<\/strong>\uff1ab\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5229\u7528\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>VDR\u306e\u611f\u53d7\u6027\u304c\u4f4e\u3044\u4eba\u306f\u3001\u901a\u5e38\u3088\u308a\u3082\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u91cf\u3092\u5897\u3084\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.2 CYP2R1\u907a\u4f1d\u5b50\uff08\u30d3\u30bf\u30df\u30f3D\u306e\u809d\u81d3\u3067\u306e\u5909\u63db\uff09<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/27699071_m-1024x683.jpg\" alt=\"\n\u30a8\u30ea\u30f3\u30ae\" class=\"wp-image-10273\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27699071_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27699071_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27699071_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27699071_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27699071_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>CYP2R1\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u809d\u81d3\u3067\u30d3\u30bf\u30df\u30f3D\u3092 <strong>25(OH)D<\/strong> \u306b\u5909\u63db\u3059\u308b\u5f79\u5272\u3092\u62c5\u3044\u307e\u3059\u3002\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u8840\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u304c\u4f4e\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-72670-6\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs10741657\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u3088\u308a\u591a\u304f\u306e\u30d3\u30bf\u30df\u30f3D\u3092\u6442\u53d6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2.3 GC\u907a\u4f1d\u5b50\uff08\u30d3\u30bf\u30df\u30f3D\u8f38\u9001\uff09<\/strong><\/h3>\n\n\n\n<p><strong>GC\u907a\u4f1d\u5b50\uff08\u30b0\u30eb\u30b3\u30b7\u30c9\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u907a\u4f1d\u5b50\uff09<\/strong> \u306f\u3001\u8840\u6db2\u4e2d\u3067\u30d3\u30bf\u30df\u30f3D\u3092\u904b\u642c\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-81461-3\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs4588\u3084rs7041\u306e\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong> \u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u8f38\u9001\u304c\u52b9\u7387\u7684\u306b\u884c\u308f\u308c\u305a\u3001\u8840\u4e2d\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u3053\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u8102\u6eb6\u6027\u306e\u30d3\u30bf\u30df\u30f3D3\u3092\u512a\u5148\u7684\u306b\u6442\u53d6\u3059\u308b\u3068\u3088\u3044\u3002<\/strong><\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u578b\u5225\u306e\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u6226\u7565<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.1 \u907a\u4f1d\u5b50\u578b\u5225\u306e\u63a8\u5968\u6442\u53d6\u91cf<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u30d3\u30bf\u30df\u30f3D\u30921.5\u301c2\u500d\u6442\u53d6<\/strong>\uff08\u98df\u54c1\uff0b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff09<\/li>\n\n\n\n<li><strong>CYP2R1\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u5b9a\u671f\u7684\u306a\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u306e\u6e2c\u5b9a\u304c\u63a8\u5968<\/strong><\/li>\n\n\n\n<li><strong>GC\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3D3\uff08\u30ea\u30dd\u30bd\u30fc\u30e0\u578b\uff09\u3092\u9078\u629e<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3.2 \u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u3073\u65b9<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5438\u53ce\u7387\u3092\u9ad8\u3081\u308b<\/strong> \u2192 <strong>D3\uff08\u30b3\u30ec\u30ab\u30eb\u30b7\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u3092\u9078\u629e<\/strong><\/li>\n\n\n\n<li><strong>\u8102\u6eb6\u6027\u304c\u5fc5\u8981\u306a\u4eba\uff08GC\u907a\u4f1d\u5b50\u5909\u7570\u578b\uff09<\/strong> \u2192 <strong>\u30aa\u30a4\u30eb\u30d9\u30fc\u30b9\u306eD3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u9078\u3076<\/strong><\/li>\n\n\n\n<li><strong>\u65e5\u5149\u5408\u6210\u304c\u96e3\u3057\u3044\u4eba\uff08CYP2R1\u5909\u7570\u578b\uff09<\/strong> \u2192 <strong>\u98df\u4e8b\u3068\u30b5\u30d7\u30ea\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u5fc5\u8981<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u81ea\u8eab\u306e\u907a\u4f1d\u5b50\u578b\u3092\u628a\u63e1\u3057\u3001\u6700\u9069\u306a\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u9078\u3073\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u9aa8\u5bc6\u5ea6\u3084\u514d\u75ab\u6a5f\u80fd\u3092\u6700\u5927\u9650\u306b\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u3068\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u306e\u30ea\u30b9\u30af<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.1 \u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u304c\u4e0d\u8db3\u3059\u308b\u3068\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3001\u7b4b\u529b\u306e\u4f4e\u4e0b\u3001\u3055\u3089\u306b\u306f\u795e\u7d4c\u7cfb\u3084\u5fc3\u8840\u7ba1\u7cfb\u306e\u5065\u5eb7\u306b\u3082\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/nrendo.2017.104\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u306e\u4e3b\u306a\u30ea\u30b9\u30af\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30fb\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u5897\u52a0<\/strong>\uff08\u30ab\u30eb\u30b7\u30a6\u30e0\u5438\u53ce\u306e\u4f4e\u4e0b\u306b\u3088\u308b\uff09<\/li>\n\n\n\n<li><strong>\u514d\u75ab\u6a5f\u80fd\u306e\u4f4e\u4e0b<\/strong>\uff08\u611f\u67d3\u75c7\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4e0a\u6607\uff09<\/li>\n\n\n\n<li><strong>\u7b4b\u8089\u306e\u8870\u3048\u3068\u8ee2\u5012\u30ea\u30b9\u30af\u306e\u5897\u52a0<\/strong>\uff08\u7279\u306b\u9ad8\u9f62\u8005\u3067\u9855\u8457\uff09<\/li>\n\n\n\n<li><strong>\u3046\u3064\u75c7\u72b6\u306e\u60aa\u5316<\/strong>\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u5408\u6210\u306b\u5f71\u97ff\uff09<\/li>\n\n\n\n<li><strong>\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u306e\u4e0a\u6607<\/strong>\uff08\u8840\u5727\u8abf\u6574\u6a5f\u80fd\u306e\u4f4e\u4e0b\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001<strong>VDR\u907a\u4f1d\u5b50\u3084CYP2R1\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong> \u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3084\u6d3b\u6027\u5316\u304c\u4f4e\u4e0b\u3057\u3001\u3053\u308c\u3089\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4.2 \u907a\u4f1d\u5b50\u3068\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u30ea\u30b9\u30af\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9939\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30960299_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u907a\u4f1d\u7684\u8981\u56e0\u306f\u8907\u6570\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u2192 \u30d3\u30bf\u30df\u30f3D\u306e\u7d30\u80de\u5185\u53d7\u5bb9\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u5bc6\u5ea6\u306e\u6e1b\u5c11\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\uff08<a href=\"https:\/\/www.nature.com\/articles\/ejcn2014254\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u2192 \u30d3\u30bf\u30df\u30f3D\u3092\u6d3b\u6027\u5316\u3059\u308b\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u304c\u4f4e\u304f\u306a\u308b\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-72670-6\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u2192 \u30d3\u30bf\u30df\u30f3D\u3092\u904b\u642c\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cf\u304c\u6e1b\u308a\u3001\u4f53\u5185\u306e\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u304c\u4f4e\u4e0b\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-81461-3\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u306b\u610f\u8b58\u3057\u3066\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u3092\u5897\u3084\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u3044\u305f\u751f\u6d3b\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.1 \u98df\u4e8b\u304b\u3089\u306e\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u306e\u5de5\u592b<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u3092\u591a\u304f\u542b\u3080\u98df\u54c1\u3092\u610f\u8b58\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u5b50\u578b\u306b\u95a2\u308f\u3089\u305a\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3092\u7dad\u6301\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u30d3\u30bf\u30df\u30f3D\u3092\u591a\u304f\u542b\u3080\u98df\u54c1<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9b5a\u4ecb\u985e<\/strong>\uff08\u30b5\u30b1\u3001\u30de\u30b0\u30ed\u3001\u30b5\u30d0\uff09<\/li>\n\n\n\n<li><strong>\u5375\u9ec4<\/strong><\/li>\n\n\n\n<li><strong>\u30ad\u30ce\u30b3\u985e<\/strong>\uff08\u7279\u306b\u7d2b\u5916\u7dda\u306b\u3055\u3089\u3057\u305f\u3082\u306e\uff09<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3D\u5f37\u5316\u98df\u54c1<\/strong>\uff08\u725b\u4e73\u3001\u30b7\u30ea\u30a2\u30eb\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u578b\u5225\u306e\u6442\u53d6\u6226\u7565\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 \u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u304c\u60aa\u3044\u305f\u3081\u3001<strong>\u98df\u4e8b\uff0b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u4f75\u7528<\/strong> \u3092\u63a8\u5968\u3002<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 \u809d\u81d3\u3067\u306e\u30d3\u30bf\u30df\u30f3D\u5909\u63db\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001<strong>\u98df\u4e8b\u304b\u3089\u306eD3\u6442\u53d6\u3092\u512a\u5148<\/strong>\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 \u8840\u6db2\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u8f38\u9001\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001<strong>\u8102\u6eb6\u6027\u306eD3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u4f7f\u7528<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.2 \u65e5\u5149\u6d74\u306e\u91cd\u8981\u6027\u3068\u907a\u4f1d\u5b50\u578b\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u7d2b\u5916\u7dda\uff08UVB\uff09\u3092\u6d74\u3073\u308b\u3053\u3068\u3067\u76ae\u819a\u3067\u5408\u6210\u3055\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u3053\u306e\u5408\u6210\u80fd\u529b\u306b\u5dee\u304c\u3042\u308b\u305f\u3081\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u3092\u7406\u89e3\u3057\u305f\u4e0a\u3067\u3001\u65e5\u5149\u6d74\u306e\u7fd2\u6163\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>UVB\u306b\u3088\u308b\u30d3\u30bf\u30df\u30f3D\u5408\u6210\u3092\u9ad8\u3081\u308b\u30dd\u30a4\u30f3\u30c8<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>1\u65e515\u301c30\u5206\u306e\u65e5\u5149\u6d74\u3092\u884c\u3046\uff08\u7279\u306b\u5348\u524d10\u6642\u301c\u5348\u5f8c3\u6642\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u9854\u30fb\u8155\u30fb\u811a\u3092\u9732\u51fa\u3059\u308b<\/strong>\uff08\u8863\u985e\u3084\u65e5\u713c\u3051\u6b62\u3081\u304cUVB\u3092\u906e\u65ad\u3059\u308b\u305f\u3081\uff09<\/li>\n\n\n\n<li><strong>\u30ac\u30e9\u30b9\u8d8a\u3057\u306e\u65e5\u5149\u3067\u306f\u306a\u304f\u3001\u76f4\u63a5\u6d74\u3073\u308b\u3053\u3068\u304c\u5fc5\u8981<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u578b\u5225\u306e\u65e5\u5149\u6d74\u306e\u30dd\u30a4\u30f3\u30c8<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 \u4f53\u5185\u3067\u306e\u5229\u7528\u52b9\u7387\u304c\u4f4e\u3044\u305f\u3081\u3001<strong>\u9577\u3081\u306e\u65e5\u5149\u6d74\uff0830\u5206\u4ee5\u4e0a\uff09<\/strong> \u3092\u63a8\u5968\u3002<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u983b\u7e41\u306a\u65e5\u5149\u6d74\u304c\u5fc5\u8981<\/strong> \u3060\u304c\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u4f75\u7528\u304c\u6709\u52b9\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u904b\u642c\u52b9\u7387\u304c\u4f4e\u3044\u305f\u3081\u3001\u65e5\u5149\u6d74\uff0b\u98df\u4e8b\uff0b\u30b5\u30d7\u30ea\u306e\u30c8\u30ea\u30d7\u30eb\u6226\u7565<\/strong> \u3092\u63a8\u5968\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5.3 \u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u5438\u53ce\u7387\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/23309829_m-1024x683.jpg\" alt=\"\n\u5185\u670d\u85ac\u3092\u670d\u7528\u3059\u308b\u82e5\u3044\u5973\u6027\" class=\"wp-image-10280\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23309829_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23309829_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23309829_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23309829_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23309829_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u7387\u3092\u6700\u5927\u9650\u306b\u9ad8\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u6442\u53d6\u30bf\u30a4\u30df\u30f3\u30b0\u3084\u4ed6\u306e\u6804\u990a\u7d20\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u6700\u9069\u306a\u6442\u53d6\u30bf\u30a4\u30df\u30f3\u30b0<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u98df\u4e8b\u4e2d\u307e\u305f\u306f\u98df\u5f8c\u306b\u6442\u53d6<\/strong>\uff08\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u306a\u306e\u3067\u3001\u98df\u4e8b\u3068\u4e00\u7dd2\u304c\u6700\u3082\u5438\u53ce\u7387\u304c\u9ad8\u3044\uff09<\/li>\n\n\n\n<li><strong>\u671d\u307e\u305f\u306f\u663c\u306b\u6442\u53d6<\/strong>\uff08\u591c\u306e\u6442\u53d6\u306f\u4f53\u5185\u6642\u8a08\u3092\u4e71\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\uff09<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5438\u53ce\u3092\u9ad8\u3081\u308b\u6804\u990a\u7d20\u3068\u306e\u7d44\u307f\u5408\u308f\u305b<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0<\/strong>\uff08\u30d3\u30bf\u30df\u30f3D\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981\uff09<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3K2<\/strong>\uff08\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u9069\u5207\u306a\u5229\u7528\u3092\u4fc3\u9032\uff09<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178<\/strong>\uff08\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3092\u9ad8\u3081\u308b\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u578b\u5225\u306e\u6442\u53d6\u30dd\u30a4\u30f3\u30c8\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u5438\u53ce\u7387\u304c\u4f4e\u3044\u305f\u3081\u3001\u30aa\u30e1\u30ac3\u3068\u7d44\u307f\u5408\u308f\u305b\u308b<\/strong>\u3002<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3068\u4e00\u7dd2\u306b\u6442\u53d6\u3057\u3001\u6d3b\u6027\u5316\u3092\u4fc3\u9032<\/strong>\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u30ea\u30dd\u30bd\u30fc\u30e0\u578b\u30d3\u30bf\u30df\u30f3D3\u3092\u9078\u3076\u3053\u3068\u3067\u5438\u53ce\u52b9\u7387\u3092\u5411\u4e0a<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001<strong>\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u305f\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u6226\u7565\u3092\u7acb\u3066\u308b\u3053\u3068\u3067\u3001\u52b9\u7387\u7684\u306b\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u3092\u7dad\u6301\u3057\u3001\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3067\u304d\u307e\u3059<\/strong>\u3002\u98df\u4e8b\u3001\u65e5\u5149\u6d74\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u6700\u9069\u5316\u3057\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u65b9\u6cd5\u3067\u30d3\u30bf\u30df\u30f3D\u306e\u5065\u5eb7\u52b9\u679c\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u3068\u30d3\u30bf\u30df\u30f3D\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.1 \u9aa8\u5bc6\u5ea6\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306e\u4e0d\u8db3\u306f\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3084\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\u7279\u306b\u3001<strong>VDR\u907a\u4f1d\u5b50\u3084CYP2R1\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u306e\u5065\u5eb7\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-71056-1\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u5225\u306e\u30ea\u30b9\u30af\u3068\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 \u9aa8\u5bc6\u5ea6\u304c\u4f4e\u304f\u306a\u308a\u3084\u3059\u3044\u305f\u3081\u3001<strong>\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30d3\u30bf\u30df\u30f3K2\u3092\u4f75\u7528<\/strong> \u3059\u308b\u3053\u3068\u3067\u9aa8\u306e\u5065\u5eb7\u3092\u5f37\u5316\u3002<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 \u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u305f\u3081\u3001<strong>D3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/strong> \u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 \u8840\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u8f38\u9001\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001<strong>\u9577\u671f\u7684\u306a\u30d3\u30bf\u30df\u30f3D\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u63a8\u5968<\/strong> \u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u63a8\u5968\u3055\u308c\u308b\u9aa8\u5bc6\u5ea6\u5411\u4e0a\u306e\u305f\u3081\u306e\u6804\u990a\u7d20<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3D3<\/strong>\uff08\u9b5a\u4ecb\u985e\u30fb\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff09<\/li>\n\n\n\n<li><strong>\u30ab\u30eb\u30b7\u30a6\u30e0<\/strong>\uff08\u4e73\u88fd\u54c1\u30fb\u30ca\u30c3\u30c4\u985e\u30fb\u8449\u7269\u91ce\u83dc\uff09<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3K2<\/strong>\uff08\u7d0d\u8c46\u30fb\u30c1\u30fc\u30ba\uff09<\/li>\n\n\n\n<li><strong>\u30de\u30b0\u30cd\u30b7\u30a6\u30e0<\/strong>\uff08\u30ca\u30c3\u30c4\u985e\u30fb\u5168\u7c92\u7a40\u7269\uff09<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.2 \u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u30d3\u30bf\u30df\u30f3D\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1024x683.jpg\" alt=\"\u30bf\u30d6\u30ec\u30c3\u30c8\u3092\u64cd\u4f5c\u3059\u308b\u7537\u6027\u533b\u5e2b\" class=\"wp-image-9770\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4803761_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u514d\u75ab\u8abf\u6574\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u514d\u75ab\u8abf\u6574\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-82143-w\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p><strong>\u30d3\u30bf\u30df\u30f3D\u304c\u95a2\u9023\u3059\u308b\u81ea\u5df1\u514d\u75ab\u75be\u60a3<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u591a\u767a\u6027\u786c\u5316\u75c7\uff08MS\uff09<\/strong><\/li>\n\n\n\n<li><strong>1\u578b\u7cd6\u5c3f\u75c5<\/strong><\/li>\n\n\n\n<li><strong>\u30ea\u30a6\u30de\u30c1\u6027\u95a2\u7bc0\u708e<\/strong><\/li>\n\n\n\n<li><strong>\u30af\u30ed\u30fc\u30f3\u75c5<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>VDR\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306e\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u3092\u5b9a\u671f\u7684\u306b\u6e2c\u5b9a<\/strong> \u3057\u3001\u4e0d\u8db3\u304c\u3042\u308c\u3070\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u88dc\u5145\u3002<\/li>\n\n\n\n<li><strong>\u6297\u708e\u75c7\u98df\u54c1\uff08\u30aa\u30e1\u30ac3\u3001\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\u3001\u7dd1\u8336\uff09\u3092\u6442\u53d6<\/strong> \u3057\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u6291\u3048\u308b\u3002<\/li>\n\n\n\n<li><strong>\u9069\u5ea6\u306a\u65e5\u5149\u6d74<\/strong> \u3067\u81ea\u7136\u306a\u30d3\u30bf\u30df\u30f3D\u5408\u6210\u3092\u4fc3\u9032\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6.3 \u30d3\u30bf\u30df\u30f3D\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001<strong>\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u751f\u6210<\/strong> \u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u3046\u3064\u75c5\u3084\u4e0d\u5b89\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u3092\u8abf\u6574\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>SLC6A4\u907a\u4f1d\u5b50\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff09<\/strong> \u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u304c\u7d44\u307f\u5408\u308f\u3055\u308b\u3053\u3068\u3067\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/tp2015249\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p><strong>\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u304c\u95a2\u4e0e\u3059\u308b\u7cbe\u795e\u75be\u60a3<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5b63\u7bc0\u6027\u3046\u3064\u75c5\uff08SAD\uff09<\/strong> \u2192 \u51ac\u5b63\u306e\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u304c\u539f\u56e0<\/li>\n\n\n\n<li><strong>\u4e00\u822c\u7684\u306a\u3046\u3064\u75c5<\/strong> \u2192 \u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u751f\u6210\u4f4e\u4e0b\u306b\u3088\u308b\u30ea\u30b9\u30af\u5897\u52a0<\/li>\n\n\n\n<li><strong>\u4e0d\u5b89\u969c\u5bb3<\/strong> \u2192 \u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u30d0\u30e9\u30f3\u30b9\u306e\u4e71\u308c<\/li>\n<\/ul>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u578b\u5225\u306e\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SLC6A4\u77ed\u7e2e\u578b\uff08S\u578b\uff09\u306e\u4eba<\/strong> \u2192 <strong>\u30d3\u30bf\u30df\u30f3D\uff0b\u30aa\u30e1\u30ac3\u8102\u80aa\u9178<\/strong> \u306e\u6442\u53d6\u3092\u5f37\u5316<\/li>\n\n\n\n<li><strong>VDR\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong> \u2192 <strong>D3\u306e\u9ad8\u7528\u91cf\u6442\u53d6<\/strong>\uff085000IU\u4ee5\u4e0a\u3092\u533b\u5e2b\u3068\u76f8\u8ac7\u306e\u4e0a\u3067\u5b9f\u65bd\uff09<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u5909\u7570\u306e\u4eba<\/strong> \u2192 <strong>\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u8102\u8cea\u3068\u4e00\u7dd2\u306b\u6442\u53d6<\/strong> \u3059\u308b\u3053\u3068\u3067\u5438\u53ce\u7387\u3092\u5411\u4e0a<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-860eb718-7fff-9099-2d43-a215fe761020\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u304f\u30d3\u30bf\u30df\u30f3D\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.1 \u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u306e\u6e2c\u5b9a\u306e\u91cd\u8981\u6027<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308a\u3001\u904e\u5270\u6442\u53d6\u306b\u3088\u308b\u30ea\u30b9\u30af\u3082\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001<strong>\u5b9a\u671f\u7684\u306b\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u3092\u6e2c\u5b9a\u3057\u3001\u9069\u5207\u306a\u91cf\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u91cd\u8981<\/strong> \u3067\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41467-018-07755-6\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p><strong>\u76ee\u5b89\u3068\u306a\u308b\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>30 ng\/mL\uff0875 nmol\/L\uff09\u4ee5\u4e0a<\/strong> \u2192 \u9069\u6b63\u30ec\u30d9\u30eb<\/li>\n\n\n\n<li><strong>20\u201330 ng\/mL\uff0850\u201375 nmol\/L\uff09<\/strong> \u2192 \u3084\u3084\u4e0d\u8db3<\/li>\n\n\n\n<li><strong>20 ng\/mL\uff0850 nmol\/L\uff09\u4ee5\u4e0b<\/strong> \u2192 \u6b20\u4e4f\u72b6\u614b<\/li>\n<\/ul>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u304f\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306e\u983b\u5ea6<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>3\u301c6\u30f6\u6708\u3054\u3068\u306b\u6e2c\u5b9a<\/strong> \u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u6442\u53d6\u91cf\u3092\u8abf\u6574\u3002<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u5b9a\u671f\u7684\u306a\u809d\u6a5f\u80fd\u691c\u67fb\u3068\u4f75\u7528\u3057\u3066\u30c1\u30a7\u30c3\u30af<\/strong>\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u8840\u6db2\u691c\u67fb\u3067\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d9\u30eb\u3082\u6e2c\u5b9a<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7.2 \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30d3\u30bf\u30df\u30f3D\u7ba1\u7406\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29272986_m-1024x683.jpg\" alt=\"\u30c7\u30fc\u30bf\u3084\u30b0\u30e9\u30d5\u3092\u8868\u793a\u3059\u308b\u30e2\u30cb\u30bf\u30fc\" class=\"wp-image-9800\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29272986_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29272986_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29272986_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29272986_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29272986_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u304c\u9032\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u5fdc\u3058\u305f\u30d3\u30bf\u30df\u30f3D\u7ba1\u7406\u304c\u3088\u308a\u7cbe\u5bc6\u306b\u884c\u3048\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002AI\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u30d7\u30e9\u30f3\u3082\u767b\u5834\u3057\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u6804\u990a\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-019-0654-x\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<p><strong>\u672a\u6765\u306e\u30d3\u30bf\u30df\u30f3D\u7ba1\u7406\u306e\u53ef\u80fd\u6027<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb\uff0b\u8840\u6db2\u691c\u67fb\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u500b\u5225\u6700\u9069\u5316<\/strong><\/li>\n\n\n\n<li><strong>\u30b9\u30de\u30fc\u30c8\u30a2\u30d7\u30ea\u3067\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u30d3\u30bf\u30df\u30f3D\u72b6\u614b\u3092\u8ffd\u8de1<\/strong><\/li>\n\n\n\n<li><strong>AI\u306b\u3088\u308b\u500b\u5225\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u51e6\u65b9<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u6700\u65b0\u306e\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u7cbe\u5bc6\u306a\u30d3\u30bf\u30df\u30f3D\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u5065\u5eb7\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001<strong>\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u304f\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u7ba1\u7406\u306f\u3001\u5065\u5eb7\u7dad\u6301\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u306a\u8981\u7d20<\/strong> \u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u3092\u7406\u89e3\u3057\u3001\u98df\u4e8b\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3001\u65e5\u5149\u6d74\u3092\u9069\u5207\u306b\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u6700\u9069\u306a\u5065\u5eb7\u6226\u7565\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>8. \u30d3\u30bf\u30df\u30f3D\u3068\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\uff1a\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3059\u308b\u5185\u5206\u6ccc\u8abf\u6574<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.1 \u30d3\u30bf\u30df\u30f3D\u3068\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001<strong>\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u8abf\u6574<\/strong> \u306b\u3082\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u306b\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3084\u81ea\u5df1\u514d\u75ab\u6027\u7532\u72b6\u817a\u75be\u60a3\uff08\u6a4b\u672c\u75c5\uff09\u3068\u306e\u95a2\u9023\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-018-36168-1\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong> \u306f\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08T3, T4\uff09\u306e\u4ee3\u8b1d\u304c\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001<strong>\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607<\/strong> \u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong> \u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6d3b\u6027\u5316\u304c\u4f4e\u4e0b\u3057\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5bfe\u7b56\u3068\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u6804\u990a\u7d20\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u52b9\u679c\u7684<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e8\u30a6\u7d20\uff08\u6d77\u85fb\u985e\uff09<\/strong> \u2192 \u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u751f\u6210\u3092\u30b5\u30dd\u30fc\u30c8<\/li>\n\n\n\n<li><strong>\u30bb\u30ec\u30f3\uff08\u30d6\u30e9\u30b8\u30eb\u30ca\u30c3\u30c4\uff09<\/strong> \u2192 \u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981<\/li>\n\n\n\n<li><strong>\u4e9c\u925b\uff08\u8d64\u8eab\u8089\u3001\u30ab\u30dc\u30c1\u30e3\u306e\u7a2e\uff09<\/strong> \u2192 \u7532\u72b6\u817a\u6a5f\u80fd\u3092\u6700\u9069\u5316<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-d865ba66-7fff-ceaf-f0ff-e831caff2b74\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.2 \u30d3\u30bf\u30df\u30f3D\u3068\u5973\u6027\u30db\u30eb\u30e2\u30f3\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\uff09\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\uff08\u5973\u6027\u30db\u30eb\u30e2\u30f3\uff09\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3068\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306f\u3001<strong>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u6e1b\u5c11\u3068\u3068\u3082\u306b\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/strong> \u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-68821-w\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u304c\u4f4e\u3044\u3068\u3001VDR\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u4e0b<\/strong> \u3057\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u52b9\u679c\u304c\u6e1b\u5c11\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u5973\u6027<\/strong> \u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u8f38\u9001\u52b9\u7387\u304c\u4f4e\u304f\u306a\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u3088\u308a\u9ad8\u7528\u91cf\u306e\u30d3\u30bf\u30df\u30f3D\u3092\u6442\u53d6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306b\u63a8\u5968\u3055\u308c\u308b\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3D3\u3068K2\u306e\u4f75\u7528<\/strong>\uff08\u30ab\u30eb\u30b7\u30a6\u30e0\u3092\u9aa8\u306b\u9069\u5207\u306b\u904b\u3076\uff09<\/li>\n\n\n\n<li><strong>\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u98df\u54c1<\/strong>\uff08\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u3001\u4e9c\u9ebb\u4ec1\u3001\u30b4\u30de\uff09<\/li>\n\n\n\n<li><strong>\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306e\u7b4b\u30c8\u30ec\uff09<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8.3 \u30d3\u30bf\u30df\u30f3D\u3068\u7537\u6027\u30db\u30eb\u30e2\u30f3\uff08\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff09\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30598399_m-1024x585.jpg\" alt=\"\u935b\u3048\u3089\u308c\u305f\u7537\u6027\u306e\u8155\" class=\"wp-image-9585\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30598399_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30598399_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30598399_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30598399_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30598399_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7537\u6027\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b<strong>\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3<\/strong> \u3082\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4f4e\u3044\u7537\u6027\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5206\u6ccc\u91cf\u304c\u5c11\u306a\u3044\u50be\u5411\u304c\u3042\u308a\u3001\u7b4b\u8089\u91cf\u306e\u6e1b\u5c11\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u304c\u8d77\u3053\u308a\u3084\u3059\u3044\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-018-36372-y\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u7537\u6027<\/strong> \u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6d3b\u6027\u5316\u304c\u4f4e\u3044\u305f\u3081\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u751f\u6210\u304c\u4e0d\u8db3\u3057\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u7537\u6027<\/strong> \u306f\u3001\u7b4b\u529b\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u6301\u4e45\u529b\u3084\u904b\u52d5\u80fd\u529b\u306b\u5f71\u97ff\u304c\u51fa\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u5897\u3084\u3059\u305f\u3081\u306e\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3D3\u30924000IU\u4ee5\u4e0a\u6442\u53d6<\/strong>\uff08\u8840\u4e2d\u6fc3\u5ea6\u3092\u6700\u9069\u5316\uff09<\/li>\n\n\n\n<li><strong>\u4e9c\u925b\u30fb\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u306e\u88dc\u7d66<\/strong>\uff08\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5408\u6210\u3092\u4fc3\u9032\uff09<\/li>\n\n\n\n<li><strong>\u7b4b\u30c8\u30ec\uff0b\u9069\u5ea6\u306a\u6709\u9178\u7d20\u904b\u52d5<\/strong>\uff08\u7279\u306b\u30b9\u30af\u30ef\u30c3\u30c8\u3084\u30c7\u30c3\u30c9\u30ea\u30d5\u30c8\uff09<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-d865ba66-7fff-ceaf-f0ff-e831caff2b74\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>9. \u30d3\u30bf\u30df\u30f3D\u3068\u8178\u5185\u74b0\u5883\uff1a\u8178\u5185\u7d30\u83cc\u3068\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.1 \u8178\u5185\u7d30\u83cc\u3068\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce<\/strong><\/h3>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3068\u4ee3\u8b1d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-019-53743-7\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u308b\u3068\u3001VDR\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3057\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u52b9\u7387\u304c\u4f4e\u4e0b\u3059\u308b<\/strong>\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3D\u306f\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u308b\u305f\u3081\u3001\u76f8\u4e92\u306b\u5f71\u97ff\u3057\u5408\u3046<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u305f\u3081\u306e\u98df\u54c1<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u767a\u9175\u98df\u54c1\uff08\u30e8\u30fc\u30b0\u30eb\u30c8\u3001\u30ad\u30e0\u30c1\u3001\u5473\u564c\uff09<\/strong> \u2192 \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3092\u6539\u5584<\/li>\n\n\n\n<li><strong>\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u30aa\u30ea\u30b4\u7cd6\u3001\u98df\u7269\u7e4a\u7dad\uff09<\/strong> \u2192 \u5584\u7389\u83cc\u3092\u5897\u3084\u3059<\/li>\n\n\n\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/strong> \u2192 \u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3092\u4fc3\u9032<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9.2 \u30d3\u30bf\u30df\u30f3D\u3068\u30ea\u30fc\u30ad\u30fc\u30ac\u30c3\u30c8\u75c7\u5019\u7fa4\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30ea\u30fc\u30ad\u30fc\u30ac\u30c3\u30c8\u75c7\u5019\u7fa4\uff08\u8178\u6f0f\u308c\u75c7\u5019\u7fa4\uff09\u306f\u3001\u8178\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u72b6\u614b\u3067\u3059\u304c\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u3053\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-70674-5\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u306f\u3001\u8178\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u8178\u5185\u74b0\u5883\u304c\u4e71\u308c\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u306f\u3001\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u306e\u904b\u642c\u304c\u3046\u307e\u304f\u3044\u304b\u305a\u3001\u8178\u306e\u708e\u75c7\u30ea\u30b9\u30af\u304c\u4e0a\u304c\u308b\u53ef\u80fd\u6027\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u30ea\u30fc\u30ad\u30fc\u30ac\u30c3\u30c8\u3092\u9632\u3050\u305f\u3081\u306e\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3D3\u3068\u30b0\u30eb\u30bf\u30df\u30f3\u306e\u4f75\u7528<\/strong>\uff08\u8178\u306e\u4fee\u5fa9\u3092\u30b5\u30dd\u30fc\u30c8\uff09<\/li>\n\n\n\n<li><strong>\u6297\u708e\u75c7\u98df\u54c1\uff08\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\u3001\u30b7\u30e7\u30a6\u30ac\u3001\u7dd1\u8336\uff09<\/strong> \u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong>\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5897\u52a0\u304c\u8178\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001<strong>\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3068\u5229\u7528\u52b9\u7387\u306f\u3001\u5358\u306b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3084\u8178\u5185\u74b0\u5883\u3001\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u308b<\/strong> \u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u3001\u500b\u3005\u306e\u4f53\u8cea\u306b\u5408\u3063\u305f\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u65b9\u6cd5\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3001\u6700\u5927\u9650\u306e\u5065\u5eb7\u52b9\u679c\u3092\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-d865ba66-7fff-ceaf-f0ff-e831caff2b74\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>10. \u30d3\u30bf\u30df\u30f3D\u3068\u708e\u75c7\uff1a\u6162\u6027\u708e\u75c7\u30ea\u30b9\u30af\u3092\u907a\u4f1d\u5b50\u304b\u3089\u5206\u6790<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/32157778_m-1024x585.jpg\" alt=\"\n\u7761\u7720\u4e2d\u306b\u82e6\u3057\u305d\u3046\u306a\u8868\u60c5\u3092\u3059\u308b\u7537\u6027\" class=\"wp-image-10287\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32157778_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32157778_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32157778_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32157778_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32157778_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.1 \u30d3\u30bf\u30df\u30f3D\u306e\u6297\u708e\u75c7\u4f5c\u7528\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u304c\u3042\u308a\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u6162\u6027\u708e\u75c7\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-71056-1\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002\u3057\u304b\u3057\u3001\u907a\u4f1d\u7684\u306a\u8981\u56e0\u306b\u3088\u3063\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6297\u708e\u75c7\u4f5c\u7528\u306e\u5f37\u3055\u304c\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6297\u708e\u75c7\u52b9\u679c\u304c\u4f4e\u4e0b\u3057\u3001\u708e\u75c7\u304c\u9577\u5f15\u304d\u3084\u3059\u3044\u3002<\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6d3b\u6027\u5316\u304c\u9045\u308c\u308b\u305f\u3081\u3001\u708e\u75c7\u53cd\u5fdc\u304c\u5236\u5fa1\u3057\u306b\u304f\u3044\u3002<\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u306e\u6fc3\u5ea6\u304c\u4f4e\u304f\u306a\u308a\u3001\u514d\u75ab\u6a5f\u80fd\u306e\u8abf\u6574\u304c\u4e0d\u5341\u5206\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-d865ba66-7fff-ceaf-f0ff-e831caff2b74\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10.2 \u30d3\u30bf\u30df\u30f3D\u3068\u708e\u75c7\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u7ba1\u7406<\/strong><\/h3>\n\n\n\n<p>\u6162\u6027\u7684\u306a\u708e\u75c7\u304c\u95a2\u4e0e\u3059\u308b\u75be\u60a3\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1<\/strong>\uff1a\u81ea\u5df1\u514d\u75ab\u306b\u3088\u308b\u95a2\u7bc0\u306e\u708e\u75c7<\/li>\n\n\n\n<li><strong>\u708e\u75c7\u6027\u8178\u75be\u60a3\uff08IBD\uff09<\/strong>\uff1a\u30af\u30ed\u30fc\u30f3\u75c5\u3084\u6f70\u760d\u6027\u5927\u8178\u708e<\/li>\n\n\n\n<li><strong>\u5fc3\u8840\u7ba1\u75be\u60a3<\/strong>\uff1a\u52d5\u8108\u786c\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u6162\u6027\u708e\u75c7<\/li>\n\n\n\n<li><strong>\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0<\/strong>\uff1a\u5185\u81d3\u8102\u80aa\u306e\u84c4\u7a4d\u3068\u95a2\u9023\u3059\u308b\u708e\u75c7<\/li>\n<\/ul>\n\n\n\n<p><strong>\u907a\u4f1d\u5b50\u578b\u5225\u306e\u708e\u75c7\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>VDR\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3084\u6297\u9178\u5316\u98df\u54c1\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/strong><\/li>\n\n\n\n<li><strong>CYP2R1\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306b\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3092\u4f75\u7528<\/strong><\/li>\n\n\n\n<li><strong>GC\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u4eba<\/strong> \u2192 <strong>\u6297\u708e\u75c7\u4f5c\u7528\u306e\u3042\u308b\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3092\u6d3b\u7528\u3057\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001<strong>\u30d3\u30bf\u30df\u30f3D\u306e\u52b9\u679c\u306f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u708e\u75c7\u3084\u514d\u75ab\u6a5f\u80fd\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059<\/strong>\u3002\u81ea\u5206\u306e\u907a\u4f1d\u5b50\u578b\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u305f\u6804\u990a\u6226\u7565\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306b\u5065\u5eb7\u3092\u7dad\u6301\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-d865ba66-7fff-ceaf-f0ff-e831caff2b74\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306e\u5438\u53ce\u3068\u4ee3\u8b1d\u306b\u306f\u3001<strong>VDR\u3001CYP2R1\u3001GC\u907a\u4f1d\u5b50<\/strong> \u306a\u3069\u304c\u95a2\u4e0e\u3057\u3001\u500b\u3005\u306e\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066\u5fc5\u8981\u306a\u6442\u53d6\u91cf\u3084\u5438\u53ce\u52b9\u7387\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001<strong>\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3001\u514d\u75ab\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3001\u6162\u6027\u708e\u75c7\u306e\u30ea\u30b9\u30af\u5897\u52a0<\/strong> \u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u9069\u5207\u306a\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u65b9\u6cd5\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9078\u3073\u65b9<\/strong> \u3092\u6700\u9069\u5316\u3067\u304d\u3001\u5065\u5eb7\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u307e\u3059\u3002\u98df\u4e8b\u3001\u65e5\u5149\u6d74\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u81ea\u5206\u306e\u907a\u4f1d\u5b50\u306b\u5408\u3063\u305f\u30d3\u30bf\u30df\u30f3D\u7ba1\u7406\u3092\u884c\u3046\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u9aa8\u306e\u5065\u5eb7\u3084\u514d\u75ab\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u6804\u990a\u7d20\u3067\u3059\u304c\u3001\u305d\u306e\u5438\u53ce\u3084\u5229\u7528\u52b9\u7387\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d\u3084\u5438\u53ce\u306b\u95a2\u308f\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u578b\u306b\u3088\u3063\u3066 [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":10266,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10265","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=10265"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10265\/revisions"}],"predecessor-version":[{"id":10294,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10265\/revisions\/10294"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/10266"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=10265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=10265"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=10265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}