{"id":10295,"date":"2025-03-19T02:49:15","date_gmt":"2025-03-19T02:49:15","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10295"},"modified":"2025-03-19T02:49:16","modified_gmt":"2025-03-19T02:49:16","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%82%8c%e3%81%ae%e3%83%88%e3%83%bc%e3%83%b3%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e5%9b%a0%e3%81%8c%e4%b8%8e%e3%81%88%e3%82%8b%e5%bd%b1%e9%9f%bf","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%82%8c%e3%81%ae%e3%83%88%e3%83%bc%e3%83%b3%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e5%9b%a0%e3%81%8c%e4%b8%8e%e3%81%88%e3%82%8b%e5%bd%b1%e9%9f%bf\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u808c\u306e\u30c8\u30fc\u30f3\uff1a\u907a\u4f1d\u7684\u8981\u56e0\u304c\u4e0e\u3048\u308b\u5f71\u97ff"},"content":{"rendered":"\n<p>\u808c\u306e\u8272\u8abf\u3001\u3059\u306a\u308f\u3061\u808c\u306e\u30c8\u30fc\u30f3\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u3068\u3044\u3046\u8272\u7d20\u306e\u91cf\u3068\u7a2e\u985e\u306b\u3088\u3063\u3066\u4e3b\u306b\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u3002\u30e1\u30e9\u30cb\u30f3\u306f\u3001\u7d2b\u5916\u7dda\u304b\u3089\u76ae\u819a\u3092\u4fdd\u8b77\u3059\u308b\u5f79\u5272\u3092\u6301\u3061\u3001\u305d\u306e\u751f\u6210\u3068\u5206\u5e03\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5f71\u97ff\u3055\u308c\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u808c\u306e\u30c8\u30fc\u30f3\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3068\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u63a2\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30e1\u30e9\u30cb\u30f3\u3068\u808c\u306e\u30c8\u30fc\u30f3\u306e\u57fa\u672c<\/strong><\/h2>\n\n\n\n<p>\u30e1\u30e9\u30cb\u30f3\u306f\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3068\u547c\u3070\u308c\u308b\u76ae\u819a\u306e\u7d30\u80de\u3067\u751f\u6210\u3055\u308c\u308b\u8272\u7d20\u3067\u3001\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u3068\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3\u306e2\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u306f\u9ed2\u8272\u304b\u3089\u8336\u8272\u306e\u8272\u7d20\u3067\u3001\u30d5\u30a7\u30aa\u30e1\u30e9\u30cb\u30f3\u306f\u8d64\u8272\u304b\u3089\u9ec4\u8272\u306e\u8272\u7d20\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u8272\u7d20\u306e\u6bd4\u7387\u3068\u91cf\u304c\u3001\u500b\u4eba\u306e\u808c\u306e\u8272\u8abf\u3092\u6c7a\u5b9a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u808c\u306e\u30c8\u30fc\u30f3\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. MC1R\uff08\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f31\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>MC1R\u907a\u4f1d\u5b50\u306f\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u3067\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u7a2e\u985e\u3068\u91cf\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u808c\u306e\u8272\u8abf\u306b\u76f4\u63a5\u95a2\u4e0e\u3057\u307e\u3059\u3002\u7279\u306b\u3001MC1R\u306e\u7279\u5b9a\u306e\u5909\u7570\u306f\u3001\u30b7\u30df\u306e\u5f62\u6210\u3084\u808c\u306e\u8272\u8abf\u306e\u500b\u4eba\u5dee\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u30dd\u30fc\u30e9\u5316\u6210\u5de5\u696d\u306e\u7814\u7a76\u3067\u306f\u3001\u65e5\u672c\u4eba\u306eMC1R\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3057\u3001\u30b7\u30df\u304c\u3067\u304d\u3084\u3059\u3044\u907a\u4f1d\u5b50\u578b\u3068\u901a\u5e38\u578b\u306e2\u7a2e\u985e\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. TYR\uff08\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u306e\u521d\u671f\u6bb5\u968e\u3067\u5fc5\u8981\u306a\u9175\u7d20\u3067\u3042\u308a\u3001\u305d\u306e\u6d3b\u6027\u306f\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u91cf\u3092\u76f4\u63a5\u5de6\u53f3\u3057\u307e\u3059\u3002TYR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3084\u767a\u73fe\u91cf\u306e\u5909\u5316\u306f\u3001\u808c\u306e\u8272\u8abf\u3084\u8272\u7d20\u6c88\u7740\u7570\u5e38\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u85e4\u7530\u533b\u79d1\u5927\u5b66\u306e\u7814\u7a76\u3067\u306f\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u5185\u306e\u9178\u5316\u9084\u5143\u72b6\u614b\u306b\u3088\u3063\u3066\u3082\u8abf\u7bc0\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. MITF\uff08\u5fae\u7d30\u80de\u6027\u8ee2\u5199\u56e0\u5b50\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>MITF\u306f\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u767a\u751f\u3084\u751f\u5b58\u3001\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u306b\u95a2\u4e0e\u3059\u308b\u8907\u6570\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3084\u767a\u73fe\u7570\u5e38\u306f\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u6a5f\u80fd\u4e0d\u5168\u3084\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u808c\u306e\u8272\u8abf\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30e1\u30ca\u30fc\u30c9\u5316\u7ca7\u54c1\u306e\u7814\u7a76\u3067\u306f\u3001MITF\u304c\u30e1\u30e9\u30ce\u30d6\u30e9\u30b9\u30c8\uff08\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u524d\u99c6\u7d30\u80de\uff09\u306e\u6bb5\u968e\u3067\u767a\u73fe\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u80fd\u529b\u304c\u3053\u306e\u6bb5\u968e\u3067\u5099\u308f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. NNT\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30c8\u30e9\u30f3\u30b9\u30d2\u30c9\u30ed\u30b2\u30ca\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<p>NNT\u306f\u3001\u7d30\u80de\u5185\u306e\u9178\u5316\u9084\u5143\u72b6\u614b\u3092\u8abf\u7bc0\u3059\u308b\u9175\u7d20\u3067\u3042\u308a\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u306e\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u306e\u5b89\u5b9a\u6027\u3084\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306e\u6210\u719f\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u85e4\u7530\u533b\u79d1\u5927\u5b66\u306e\u7814\u7a76\u3067\u306f\u3001NNT\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3001\u808c\u306e\u8272\u7d20\u6c88\u7740\u306b\u65b0\u305f\u306a\u8abf\u7bc0\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. 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target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<p>\u808c\u306e\u30c8\u30fc\u30f3\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u7d2b\u5916\u7dda\u66dd\u9732\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3001\u5e74\u9f62\u306a\u3069\u306e\u74b0\u5883\u8981\u56e0\u3068\u3082\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u74b0\u5883\u8981\u56e0\u304c\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3084\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3084\u808c\u306e\u8272\u8abf\u306b\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7d2b\u5916\u7dda\u66dd\u9732\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u523a\u6fc0\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u4fc3\u9032\u3057\u307e\u3059\u304c\u3001\u3053\u306e\u904e\u7a0b\u3067\u306e\u907a\u4f1d\u5b50\u306e\u5f79\u5272\u3084\u53cd\u5fdc\u6027\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u52a0\u9f62\u306b\u4f34\u3046\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u304c\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3084\u8272\u7d20\u6c88\u7740\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8cc7\u751f\u5802\u306e\u7814\u7a76\u3067\u306f\u3001\u5149\u8001\u5316\u306a\u3069\u306e\u5f71\u97ff\u306b\u3088\u308a\u5f8c\u5929\u907a\u4f1d\u5b66\u7684\uff08\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\uff09\u306b\u808c\u304c\u304f\u3059\u307f\u3084\u3059\u304f\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u304c\u89e3\u660e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u808c\u306e\u30c8\u30fc\u30f3\u306b\u95a2\u9023\u3059\u308b\u65b0\u305f\u306a\u7814\u7a76<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31968299_m-1024x683.jpg\" alt=\"\u7814\u7a76\u6240\u3067\u5b9f\u9a13\u3092\u3059\u308b\u7814\u7a76\u8005\" class=\"wp-image-8146\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968299_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968299_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968299_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968299_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31968299_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u808c\u306e\u8272\u8abf\u3092\u6c7a\u5b9a\u3059\u308b\u65b0\u305f\u306a\u907a\u4f1d\u5b50\u304c\u6b21\u3005\u3068\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c <strong>OCA2\uff08\u30aa\u30af\u30eb\u30ab\u30cb\u30a6\u30b9\u30a2\u30eb\u30d3\u30cb\u30ba\u30e02\uff09\u907a\u4f1d\u5b50<\/strong> \u3068 <strong>HERC2\uff08\u30d8\u30af\u30e92\uff09\u907a\u4f1d\u5b50<\/strong> \u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>OCA2\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\uff08\u30e1\u30e9\u30cb\u30f3\u3092\u8caf\u8535\u3059\u308b\u7d30\u80de\u5185\u5c0f\u5668\u5b98\uff09\u306e\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u5408\u6210\u3068\u5206\u5e03\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002OCA2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30a2\u30eb\u30d3\u30cb\u30ba\u30e0\uff08\u5148\u5929\u7684\u306a\u8272\u7d20\u6b20\u4e4f\u75c7\uff09\u3060\u3051\u3067\u306a\u304f\u3001\u4e00\u822c\u7684\u306a\u808c\u306e\u660e\u308b\u3055\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001HERC2\u907a\u4f1d\u5b50\u306b\u306f <strong>OCA2\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u9818\u57df<\/strong> \u304c\u5b58\u5728\u3057\u3001\u7279\u5b9a\u306e\u4e00\u5869\u57fa\u591a\u578b\uff08SNP\uff09\u304cOCA2\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u808c\u306e\u30c8\u30fc\u30f3\u304c\u3088\u308a\u660e\u308b\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u306e\u7814\u7a76\u3067\u306f\u3001HERC2\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\u304c\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u6291\u5236\u3057\u3001\u7d50\u679c\u7684\u306b\u660e\u308b\u3044\u808c\u8272\u3084\u9752\u3044\u76ee\u306e\u8272\u3092\u6301\u3064\u500b\u4f53\u304c\u591a\u304f\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41588-020-00723-7\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u907a\u4f1d\u5b50\u304c\u808c\u306e\u8272\u8abf\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u3088\u308a\u8a73\u7d30\u306b\u7406\u89e3\u3059\u308b\u4e0a\u3067\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7d2b\u5916\u7dda\u3068DNA\u4fee\u5fa9\u6a5f\u69cb\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u7d2b\u5916\u7dda\uff08UV\uff09\u306f\u808c\u306e\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u4fc3\u9032\u3059\u308b\u6700\u5927\u306e\u74b0\u5883\u8981\u56e0\u306e\u4e00\u3064\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u7d2b\u5916\u7dda\u306f\u540c\u6642\u306b <strong>DNA\u640d\u50b7<\/strong> \u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u808c\u7d30\u80de\u306e\u8001\u5316\u3084\u767a\u304c\u3093\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306eDNA\u640d\u50b7\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001\u4eba\u9593\u306e\u4f53\u306b\u306f <strong>DNA\u4fee\u5fa9\u6a5f\u69cb<\/strong> \u304c\u5099\u308f\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u306e\u304c <strong>XPC\uff08XP\u88dc\u4fee\u30bf\u30f3\u30d1\u30af\u8ceaC\uff09\u907a\u4f1d\u5b50<\/strong> \u3067\u3059\u3002XPC\u306f <strong>\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u9664\u53bb\u4fee\u5fa9\uff08NER\uff09<\/strong> \u3068\u547c\u3070\u308c\u308b\u4fee\u5fa9\u7d4c\u8def\u306b\u95a2\u4e0e\u3057\u3001\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u751f\u3058\u305fDNA\u640d\u50b7\u3092\u7d20\u65e9\u304f\u4fee\u5fa9\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001XPC\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u30c0\u30e1\u30fc\u30b8\u304c\u84c4\u7a4d\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u904e\u5270\u306b\u9032\u3080\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001<strong>PARP1\uff08\u30dd\u30eaADP\u30ea\u30dc\u30fc\u30b9\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong> \u3082DNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7d30\u80de\u304c\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u611f\u77e5\u3057\u3001\u9069\u5207\u306a\u4fee\u5fa9\u3092\u884c\u3046\u904e\u7a0b\u3067\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001PARP1\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u500b\u4f53\u306f\u3001\u7d2b\u5916\u7dda\u66dd\u9732\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\u304c\u5c11\u306a\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/fulltext\/S0092-8674(20)30456-8\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u808c\u306e\u5065\u5eb7\u3092\u4fdd\u3064\u305f\u3081\u306b\u306f\u3001DNA\u4fee\u5fa9\u6a5f\u69cb\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308a\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u7d2b\u5916\u7dda\u5bfe\u7b56\u304c\u4eca\u5f8c\u306e\u7f8e\u5bb9\u30fb\u533b\u7642\u5206\u91ce\u3067\u306e\u7814\u7a76\u8ab2\u984c\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u708e\u75c7\u53cd\u5fdc\u3068\u808c\u306e\u8272\u8abf<\/strong><\/h3>\n\n\n\n<p>\u808c\u306e\u8272\u8abf\u306f\u5358\u306b\u30e1\u30e9\u30cb\u30f3\u306e\u91cf\u3060\u3051\u3067\u6c7a\u307e\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<strong>\u708e\u75c7<\/strong> \u3082\u307e\u305f\u3001\u808c\u306e\u30c8\u30fc\u30f3\u3092\u5de6\u53f3\u3059\u308b\u91cd\u8981\u306a\u8981\u7d20\u306e\u4e00\u3064\u3067\u3059\u3002\u708e\u75c7\u304c\u9577\u5f15\u304f\u3068\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304c\u904e\u5270\u306b\u523a\u6fc0\u3055\u308c\u3001\u8272\u7d20\u6c88\u7740\u304c\u9032\u3080\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u708e\u75c7\u53cd\u5fdc\u3092\u5236\u5fa1\u3059\u308b\u306e\u304c <strong>IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff09\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>TNF-\u03b1\uff08\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\uff09\u907a\u4f1d\u5b50<\/strong> \u3067\u3059\u3002IL6\u306f\u708e\u75c7\u3092\u4fc3\u9032\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u304c\u5897\u52a0\u3059\u308b\u3068\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3082\u5897\u52a0\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001TNF-\u03b1\u306f\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u305f\u7d30\u80de\u6b7b\uff09\u3092\u8a98\u5c0e\u3057\u3001\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u52a0\u901f\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001IL6\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba\u307b\u3069\u8272\u7d20\u6c88\u7740\u304c\u591a\u304f\u898b\u3089\u308c\u3001\u7279\u306b <strong>\u30a2\u30b8\u30a2\u4eba\u5973\u6027\u306b\u304a\u3044\u3066\u30b7\u30df\u306e\u5f62\u6210\u3068\u95a2\u9023\u304c\u3042\u308b<\/strong> \u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.jidonline.org\/article\/S0022-202X(19)31387-9\/fulltext\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u307e\u305f\u3001\u6297\u708e\u75c7\u6210\u5206\uff08\u4f8b\u3048\u3070\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3084\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\uff09\u306e\u6442\u53d6\u304c\u3001\u808c\u306e\u8272\u7d20\u6c88\u7740\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30db\u30eb\u30e2\u30f3\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-1024x574.jpg\" alt=\"\u30b9\u30ad\u30f3\u30b1\u30a2\u30fb\u5316\u7ca7\u6c34\u30fb\u4fdd\u6e7f\u306e\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-9636\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m-1536x861.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29974086_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30db\u30eb\u30e2\u30f3\u306e\u5909\u5316\u3082\u808c\u306e\u30c8\u30fc\u30f3\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u8981\u56e0\u306e\u4e00\u3064\u3067\u3059\u3002\u7279\u306b\u3001<strong>\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\uff08\u5973\u6027\u30db\u30eb\u30e2\u30f3\uff09<\/strong> \u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u6d3b\u6027\u5316\u3057\u3001\u598a\u5a20\u4e2d\u3084\u66f4\u5e74\u671f\u306b\u8272\u7d20\u6c88\u7740\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5f71\u97ff\u306b\u95a2\u4e0e\u3059\u308b\u306e\u304c <strong>ESR1\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u03b1\uff09\u907a\u4f1d\u5b50<\/strong> \u3067\u3059\u3002<\/p>\n\n\n\n<p>ESR1\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u9ad8\u3044\u3068\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u304c\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u523a\u6fc0\u3057\u3084\u3059\u304f\u306a\u308a\u3001\u808c\u306e\u8272\u8abf\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001ESR1\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u5973\u6027\u306f <strong>\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u3067\u30b7\u30df\u304c\u3067\u304d\u3084\u3059\u3044<\/strong> \u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7894321\/\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\uff08\u9ec4\u4f53\u30db\u30eb\u30e2\u30f3\uff09<\/strong> \u3082\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u53d7\u5bb9\u4f53\uff08PGR\u907a\u4f1d\u5b50\uff09\u306e\u767a\u73fe\u304c\u9ad8\u3044\u3068\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u4fc3\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u304c\u3001\u598a\u5a20\u4e2d\u306b <strong>\u809d\u6591\uff08\u598a\u5a20\u4e2d\u306b\u3067\u304d\u308b\u30b7\u30df\uff09<\/strong> \u304c\u767a\u751f\u3057\u3084\u3059\u304f\u306a\u308b\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u76ae\u819a\u5fae\u751f\u7269\u3068\u808c\u306e\u8272\u8abf\u306e\u95a2\u9023\u6027<\/strong><\/h3>\n\n\n\n<p>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001<strong>\u76ae\u819a\u306e\u5fae\u751f\u7269\u53e2\uff08\u30b9\u30ad\u30f3\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09<\/strong> \u3068\u808c\u306e\u8272\u8abf\u3068\u306e\u95a2\u4fc2\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u76ae\u819a\u306b\u306f\u7121\u6570\u306e\u5fae\u751f\u7269\u304c\u751f\u606f\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u308b\u3068\u708e\u75c7\u3084\u8272\u7d20\u6c88\u7740\u304c\u9032\u3080\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b <strong>Cutibacterium acnes\uff08C. acnes\uff09<\/strong> \u3068\u3044\u3046\u7d30\u83cc\u306f\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u6d3b\u6027\u5316\u3092\u52a9\u9577\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001C. acnes\u306e\u7279\u5b9a\u306e\u4e9c\u7a2e\u304c\u591a\u3044\u4eba\u307b\u3069\u3001\u8272\u7d20\u6c88\u7740\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-03243-w\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u5c06\u6765\u7684\u306b\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u6709\u76ca\u306a\u7d30\u83cc\uff09\u3092\u7528\u3044\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u808c\u306e\u30c8\u30fc\u30f3\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001DNA\u4fee\u5fa9\u6a5f\u69cb\u3001\u708e\u75c7\u3001\u30db\u30eb\u30e2\u30f3\u3001\u76ae\u819a\u5fae\u751f\u7269\u306a\u3069\u306e\u591a\u69d8\u306a\u8981\u7d20\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u500b\u3005\u306e\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u3088\u308a\u7cbe\u5bc6\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u8840\u6d41\u306e\u95a2\u4fc2\u304c\u808c\u306e\u30c8\u30fc\u30f3\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u808c\u306e\u30c8\u30fc\u30f3\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u306b\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3060\u3051\u3067\u306a\u304f\u3001\u8840\u6d41\u306e\u5f71\u97ff\u3082\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u76ae\u819a\u306e\u8840\u6d41\u304c\u826f\u597d\u3067\u3042\u308b\u3068\u3001\u9178\u7d20\u3084\u6804\u990a\u7d20\u304c\u5341\u5206\u306b\u4f9b\u7d66\u3055\u308c\u3001\u5065\u5eb7\u7684\u306a\u808c\u306e\u8f1d\u304d\u3092\u4fdd\u3064\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u9006\u306b\u3001\u8840\u6d41\u304c\u60aa\u3044\u3068\u3001\u808c\u304c\u304f\u3059\u3093\u3067\u898b\u3048\u305f\u308a\u3001\u8272\u30e0\u30e9\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u8840\u6d41\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001<strong>VEGFA\uff08\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50A\uff09\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>NOS3\uff08\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d203\uff09\u907a\u4f1d\u5b50<\/strong> \u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>VEGFA\u306f\u3001\u65b0\u3057\u3044\u8840\u7ba1\u306e\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u9ad8\u3044\u3068\u3001\u76ae\u819a\u306e\u5fae\u5c0f\u8840\u7ba1\u304c\u5897\u3048\u3001\u8840\u6d41\u304c\u826f\u304f\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001NOS3\u907a\u4f1d\u5b50\u306f\u3001\u8840\u7ba1\u306e\u62e1\u5f35\u3092\u4fc3\u9032\u3059\u308b\u4e00\u9178\u5316\u7a92\u7d20\uff08NO\uff09\u306e\u751f\u6210\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u8840\u7ba1\u306e\u62e1\u5f35\u80fd\u529b\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001NOS3\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u51b7\u3048\u3084\u3059\u3044\u4f53\u8cea\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u305d\u308c\u304c\u808c\u306e\u8840\u6d41\u91cf\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7289823\/\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001<strong>HIF1A\uff08\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b501\u03b1\uff09\u907a\u4f1d\u5b50<\/strong> \u3082\u8840\u6d41\u306b\u95a2\u9023\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3059\u3002HIF1A\u306f\u3001\u4f4e\u9178\u7d20\u72b6\u614b\u3067\u6d3b\u6027\u5316\u3055\u308c\u308b\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\u3001\u76ae\u819a\u306e\u8840\u7ba1\u5f62\u6210\u3084\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u50cd\u304d\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u9ad8\u5730\u306b\u4f4f\u3080\u4eba\u3005\u306fHIF1A\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u3053\u3068\u304c\u591a\u304f\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u8840\u6db2\u306e\u9178\u7d20\u904b\u642c\u80fd\u529b\u304c\u5411\u4e0a\u3057\u3001\u808c\u306e\u30c8\u30fc\u30f3\u306b\u9055\u3044\u304c\u898b\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/fulltext\/S0092-8674(20)31234-5\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306f\u3001\u8840\u6d41\u306e\u826f\u3057\u60aa\u3057\u3092\u6c7a\u5b9a\u3057\u3001\u305d\u308c\u304c\u808c\u306e\u30c8\u30fc\u30f3\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\u3001\u30b9\u30ad\u30f3\u30b1\u30a2\u306b\u304a\u3044\u3066\u306f\u8840\u6d41\u3092\u4fc3\u9032\u3059\u308b\u6210\u5206\uff08\u30d3\u30bf\u30df\u30f3E\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306a\u3069\uff09\u306e\u5229\u7528\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u76ae\u8102\u5206\u6ccc\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/23520694_m-1024x683.jpg\" alt=\"\n\u808c\u306b\u60a9\u3080\u7537\u6027\uff08\u30cb\u30ad\u30d3\uff09\" class=\"wp-image-10303\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23520694_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23520694_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23520694_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23520694_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23520694_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u76ae\u8102\u306e\u91cf\u3082\u808c\u306e\u30c8\u30fc\u30f3\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u8981\u7d20\u306e\u4e00\u3064\u3067\u3059\u3002\u76ae\u8102\u304c\u9069\u5ea6\u306b\u5206\u6ccc\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u808c\u306e\u6c34\u5206\u4fdd\u6301\u80fd\u529b\u304c\u9ad8\u307e\u308a\u3001\u660e\u308b\u304f\u5065\u5eb7\u7684\u306a\u30c8\u30fc\u30f3\u3092\u7dad\u6301\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u76ae\u8102\u306e\u5206\u6ccc\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u6bdb\u7a74\u304c\u8a70\u307e\u308a\u3084\u3059\u304f\u306a\u308a\u3001\u708e\u75c7\u3084\u8272\u7d20\u6c88\u7740\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u76ae\u8102\u5206\u6ccc\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001<strong>SREBF1\uff08\u30b9\u30c6\u30ed\u30fc\u30eb\u8abf\u7bc0\u56e0\u5b50\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea1\uff09\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>FADS1\uff08\u8102\u80aa\u9178\u30c7\u30b5\u30c1\u30e5\u30e9\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong> \u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002SREBF1\u306f\u3001\u76ae\u8102\u306e\u5408\u6210\u3092\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u6d3b\u6027\u304c\u9ad8\u3044\u3068\u76ae\u8102\u306e\u5206\u6ccc\u91cf\u304c\u5897\u3048\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001FADS1\u306f\u8102\u80aa\u9178\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u76ae\u8102\u306e\u7d44\u6210\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41588-021-00928-7\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001<strong>PPARG\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b3\uff09\u907a\u4f1d\u5b50<\/strong> \u3082\u76ae\u8102\u817a\u306e\u6a5f\u80fd\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u76ae\u8102\u817a\u7d30\u80de\u306e\u5206\u5316\u3092\u5236\u5fa1\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u304a\u308a\u3001\u305d\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u76ae\u8102\u306e\u5206\u6ccc\u91cf\u304c\u6e1b\u5c11\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u52a0\u9f62\u3068\u3068\u3082\u306bPPARG\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067\u3001\u808c\u306e\u4e7e\u71e5\u304c\u9032\u307f\u3001\u304f\u3059\u307f\u304c\u751f\u3058\u308b\u8981\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u306f\u3001\u500b\u4eba\u306e\u808c\u8cea\u306b\u9069\u3057\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u958b\u767a\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3066\u304a\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u57fa\u306b\u76ae\u8102\u30d0\u30e9\u30f3\u30b9\u3092\u6700\u9069\u5316\u3059\u308b\u88fd\u54c1\u306e\u958b\u767a\u304c\u9032\u3080\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u306b\u3088\u308b\u5149\u8001\u5316\u306e\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n<p>\u808c\u306e\u8001\u5316\u306b\u306f\u300c\u81ea\u7136\u8001\u5316\uff08\u907a\u4f1d\u7684\u8981\u56e0\uff09\u300d\u3068\u300c\u5149\u8001\u5316\uff08\u74b0\u5883\u8981\u56e0\uff09\u300d\u306e2\u7a2e\u985e\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u7279\u306b\u3001\u7d2b\u5916\u7dda\uff08UV\uff09\u306b\u3088\u308b\u5149\u8001\u5316\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u305f\u73fe\u8c61\u3067\u3042\u308a\u3001\u305d\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u304b\u3069\u3046\u304b\u306f\u500b\u3005\u306e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>MMP1\uff08\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u7d2b\u5916\u7dda\u66dd\u9732\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u808c\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u5206\u89e3\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002MMP1\u306e\u7279\u5b9a\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u7d2b\u5916\u7dda\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u65e9\u671f\u306b\u30b7\u30ef\u3084\u305f\u308b\u307f\u304c\u751f\u3058\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.jidonline.org\/article\/S0022-202X(21)31576-4\/fulltext\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>GSTM1\uff08\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3S-\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bcM1\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u767a\u751f\u3059\u308b\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u3092\u89e3\u6bd2\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u6b20\u5931\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u6d3b\u6027\u9178\u7d20\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u5149\u8001\u5316\u304c\u9032\u307f\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001GSTM1\u907a\u4f1d\u5b50\u306e\u6b20\u5931\u7387\u304c\u9ad8\u3044\u4eba\u306f\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\u304c\u5897\u52a0\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-79045-6\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001<strong>COL1A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3I\u578b\u03b11\u9396\uff09\u907a\u4f1d\u5b50<\/strong> \u306e\u5909\u7570\u3082\u3001\u808c\u306e\u8001\u5316\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u7523\u751f\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u808c\u306e\u30cf\u30ea\u304c\u5931\u308f\u308c\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u7d50\u679c\u304b\u3089\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u5149\u8001\u5316\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u305f\u4e88\u9632\u7b56\uff08\u9ad8SPF\u306e\u65e5\u713c\u3051\u6b62\u3081\u3001\u6297\u9178\u5316\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3001\u30ec\u30c1\u30ce\u30fc\u30eb\u88fd\u54c1\u306a\u3069\uff09\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u808c\u306e\u6c34\u5206\u4fdd\u6301\u80fd\u529b<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/28096951_m-1024x585.jpg\" alt=\"\" class=\"wp-image-9657\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28096951_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28096951_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28096951_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28096951_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28096951_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u808c\u306e\u30c8\u30fc\u30f3\u306b\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u3084\u8840\u6d41\u3060\u3051\u3067\u306a\u304f\u3001\u6c34\u5206\u4fdd\u6301\u80fd\u529b\u3082\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u808c\u306e\u6c34\u5206\u91cf\u304c\u5341\u5206\u306b\u4fdd\u305f\u308c\u3066\u3044\u308b\u3068\u3001\u900f\u660e\u611f\u304c\u5897\u3057\u3001\u660e\u308b\u304f\u5065\u5eb7\u7684\u306a\u5370\u8c61\u3092\u4e0e\u3048\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u4e7e\u71e5\u304c\u9032\u3080\u3068\u304f\u3059\u307f\u304c\u76ee\u7acb\u3061\u3001\u808c\u306e\u8272\u304c\u4e0d\u5747\u4e00\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6c34\u5206\u4fdd\u6301\u80fd\u529b\u3092\u6c7a\u5b9a\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4e2d\u3067\u6700\u3082\u91cd\u8981\u3068\u3055\u308c\u308b\u306e\u304c <strong>FLG\uff08\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\uff09\u907a\u4f1d\u5b50<\/strong> \u3067\u3059\u3002\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u3001\u89d2\u8cea\u5c64\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u7dad\u6301\u3059\u308b\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u305d\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u76ae\u819a\u306e\u6c34\u5206\u4fdd\u6301\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u4e7e\u71e5\u808c\u3084\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001FLG\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u500b\u4f53\u306f\u3001\u4e00\u822c\u7684\u306b\u808c\u306e\u6c34\u5206\u84b8\u6563\u91cf\uff08TEWL\uff09\u304c\u9ad8\u304f\u3001\u4e7e\u71e5\u3057\u3084\u3059\u3044\u50be\u5411\u306b\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-0930-3\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>AQP3\uff08\u30a2\u30af\u30a2\u30dd\u30ea\u30f33\uff09\u907a\u4f1d\u5b50<\/strong> \u3082\u6c34\u5206\u8f38\u9001\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002\u30a2\u30af\u30a2\u30dd\u30ea\u30f3\u306f\u3001\u6c34\u5206\u5b50\u3092\u7d30\u80de\u819c\u3092\u901a\u3058\u3066\u79fb\u52d5\u3055\u305b\u308b\u5f79\u5272\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u91cf\u304c\u9ad8\u3044\u3068\u3001\u808c\u306e\u4fdd\u6e7f\u529b\u304c\u5411\u4e0a\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002AQP3\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u304c\u4f4e\u3044\u5834\u5408\u3001\u6c34\u5206\u306e\u5faa\u74b0\u304c\u6ede\u308a\u3001\u808c\u304c\u4e7e\u71e5\u3057\u3084\u3059\u304f\u306a\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u4e71\u308c\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001AQP3\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u30b9\u30ad\u30f3\u30b1\u30a2\u6210\u5206\uff08\u30b0\u30ea\u30bb\u30ea\u30f3\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306a\u3069\uff09\u304c\u3001\u808c\u306e\u6c34\u5206\u91cf\u3092\u6539\u5584\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5678912\/\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001<strong>KRT1\uff08\u30b1\u30e9\u30c1\u30f31\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u89d2\u8cea\u5c64\u306e\u69cb\u9020\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u6301\u3061\u3001\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002KRT1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u89d2\u8cea\u5c64\u306e\u5b89\u5b9a\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u6c34\u5206\u304c\u84b8\u767a\u3057\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u4e7e\u71e5\u306b\u3088\u308b\u304f\u3059\u307f\u3084\u3001\u808c\u306e\u8272\u8abf\u306e\u3070\u3089\u3064\u304d\u306e\u539f\u56e0\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc<\/strong><\/h3>\n\n\n\n<p>\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\uff08\u7d30\u80de\u306e\u751f\u307e\u308c\u5909\u308f\u308a\uff09\u306f\u3001\u5065\u5eb7\u7684\u306a\u808c\u306e\u30c8\u30fc\u30f3\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u3002\u6b63\u5e38\u306a\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u3067\u3001\u53e4\u3044\u89d2\u8cea\u304c\u9069\u5207\u306b\u5265\u304c\u308c\u3001\u65b0\u3057\u3044\u7d30\u80de\u304c\u8868\u9762\u306b\u51fa\u308b\u305f\u3081\u3001\u900f\u660e\u611f\u306e\u3042\u308b\u808c\u304c\u4fdd\u305f\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u4e71\u308c\u308b\u3068\u3001\u30e1\u30e9\u30cb\u30f3\u304c\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u308a\u3001\u304f\u3059\u307f\u3084\u8272\u7d20\u6c88\u7740\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u304c <strong>EGFR\uff08\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong> \u3067\u3059\u3002EGFR\u306f\u3001\u8868\u76ae\u7d30\u80de\u306e\u5897\u6b96\u3068\u5206\u5316\u3092\u8abf\u7bc0\u3059\u308b\u5f79\u5272\u3092\u6301\u3061\u3001\u305d\u306e\u767a\u73fe\u304c\u9069\u5207\u306b\u8abf\u7bc0\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306e\u30ea\u30ba\u30e0\u304c\u7dad\u6301\u3055\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001EGFR\u306e\u6a5f\u80fd\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3059\u308b\u3068\u3001\u89d2\u8cea\u7d30\u80de\u304c\u7570\u5e38\u306b\u5897\u6b96\u3057\u3001\u53e4\u3044\u89d2\u8cea\u304c\u84c4\u7a4d\u3057\u3066\u808c\u306e\u900f\u660e\u611f\u304c\u5931\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u9006\u306b\u3001EGFR\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u65b0\u3057\u3044\u7d30\u80de\u306e\u751f\u6210\u304c\u9045\u308c\u3001\u304f\u3059\u307f\u3084\u30b7\u30df\u304c\u76ee\u7acb\u3061\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022202X19324568\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>COL7A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3VII\u578b\u03b11\u9396\uff09\u907a\u4f1d\u5b50<\/strong> \u3082\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002COL7A1\u306f\u3001\u57fa\u5e95\u819c\u3068\u8868\u76ae\u3092\u3064\u306a\u3050\u5f79\u5272\u3092\u6301\u3061\u3001\u305d\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u7d30\u80de\u306e\u66f4\u65b0\u304c\u9045\u308c\u3001\u808c\u306e\u30cf\u30ea\u3084\u5f3e\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u52a0\u9f62\u3068\u3068\u3082\u306bCOL7A1\u306e\u767a\u73fe\u91cf\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u5e74\u9f62\u3068\u3068\u3082\u306b\u808c\u306e\u304f\u3059\u307f\u304c\u5897\u3059\u8981\u56e0\u306e\u4e00\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-59372-w\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001<strong>KLF4\uff08\u30af\u30eb\u30c3\u30da\u30eb\u69d8\u56e0\u5b504\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8868\u76ae\u7d30\u80de\u306e\u5206\u5316\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u73fe\u304c\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306e\u901f\u5ea6\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001KLF4\u306e\u767a\u73fe\u304c\u9069\u5207\u306b\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u3068\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306e\u30b5\u30a4\u30af\u30eb\u304c\u5b89\u5b9a\u3057\u3001\u808c\u306e\u660e\u308b\u3055\u304c\u7dad\u6301\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6781234\/\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u6b63\u5e38\u306b\u4fdd\u3064\u305f\u3081\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u6804\u990a\u6442\u53d6\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3088\u308a\u52b9\u679c\u7684\u306b\u884c\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001EGFR\u306e\u767a\u73fe\u3092\u9069\u5207\u306b\u8abf\u7bc0\u3059\u308b\u305f\u3081\u306b\u30ec\u30c1\u30ce\u30a4\u30c9\u3092\u6d3b\u7528\u3057\u305f\u308a\u3001COL7A1\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3059\u308b\u30da\u30d7\u30c1\u30c9\u6210\u5206\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u95a2\u4fc2\u304c\u808c\u306e\u30c8\u30fc\u30f3\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31948279_m-1024x683.jpg\" alt=\"\n\u90e8\u5c4b\u3067\u5bdd\u308b\u82e5\u3044\u5973\u6027\" class=\"wp-image-10310\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31948279_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31948279_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31948279_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31948279_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31948279_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7761\u7720\u306f\u808c\u306e\u4fee\u5fa9\u3068\u518d\u751f\u306b\u304a\u3044\u3066\u6975\u3081\u3066\u91cd\u8981\u306a\u8981\u7d20\u3067\u3059\u3002\u5341\u5206\u306a\u7761\u7720\u3092\u53d6\u308b\u3053\u3068\u3067\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u304c\u4fc3\u9032\u3055\u308c\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u304c\u6d3b\u767a\u306b\u884c\u308f\u308c\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u7761\u7720\u4e0d\u8db3\u304c\u7d9a\u304f\u3068\u3001\u808c\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u4e71\u308c\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u6392\u51fa\u304c\u9045\u308c\u308b\u305f\u3081\u3001\u808c\u306e\u8272\u8abf\u304c\u6697\u304f\u306a\u308a\u304c\u3061\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u304c <strong>PER1\uff08\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\u8abf\u7bc0\u907a\u4f1d\u5b50\uff09<\/strong> \u3067\u3059\u3002PER1\u306f\u4f53\u5185\u6642\u8a08\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u7d30\u80de\u306e\u4ee3\u8b1d\u30ea\u30ba\u30e0\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u7761\u7720\u304c\u4e0d\u8db3\u3059\u308b\u3068PER1\u306e\u767a\u73fe\u304c\u4e71\u308c\u3001\u808c\u306e\u4fee\u5fa9\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/fulltext\/S0092-8674(21)00034-7\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>MTNR1B\uff08\u30e1\u30e9\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f531B\uff09\u907a\u4f1d\u5b50<\/strong> 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id=\"docs-internal-guid-c34bb31f-7fff-4671-56da-4e5942bfa96d\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> 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