{"id":10318,"date":"2025-03-19T03:02:51","date_gmt":"2025-03-19T03:02:51","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10318"},"modified":"2025-03-19T03:02:52","modified_gmt":"2025-03-19T03:02:52","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%8c%e7%a4%ba%e3%81%99%e7%97%85%e6%b0%97%e3%81%ae%e5%89%8d%e5%85%86%e3%81%a8%e6%97%a9%e6%9c%9f%e5%af%be%e5%bf%9c%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%8c%e7%a4%ba%e3%81%99%e7%97%85%e6%b0%97%e3%81%ae%e5%89%8d%e5%85%86%e3%81%a8%e6%97%a9%e6%9c%9f%e5%af%be%e5%bf%9c%e6%b3%95\/","title":{"rendered":"\u907a\u4f1d\u5b50\u304c\u793a\u3059\u75c5\u6c17\u306e\u524d\u5146\u3068\u65e9\u671f\u5bfe\u5fdc\u6cd5"},"content":{"rendered":"\n

\u8fd1\u5e74\u306e\u30b2\u30ce\u30e0\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3066\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u65e9\u671f\u5bfe\u5fdc\u3092\u56f3\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u691c\u51fa\u306f\u3001\u75be\u60a3\u306e\u65e9\u671f\u767a\u898b\u3084\u4e88\u9632\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

1. \u907a\u4f1d\u5b50\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308b\u65e9\u671f\u30ea\u30b9\u30af\u8a55\u4fa1<\/strong><\/p>\n\n\n\n

\u30b9\u30bf\u30f3\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u3068\u82f1\u56fd\u306e\u533b\u7642\u4f01\u696dGenomics\u304c\u5171\u540c\u3067\u884c\u3063\u305f\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4e73\u304c\u3093\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u306a\u3069\u306e\u4e00\u822c\u7684\u306a\u75be\u60a3\u306b\u3088\u308b\u65e9\u671f\u6b7b\u4ea1\u3092\u6700\u592725\uff05\u6e1b\u5c11\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u82f1\u56fd\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u306e40\u4e07\u4eba\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3001\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u3092\u7528\u3044\u30669\u3064\u306e\u75be\u60a3\u306e\u9ad8\u30ea\u30b9\u30af\u7fa4\u3092\u7279\u5b9a\u3057\u307e\u3057\u305f\u3002\u9ad8\u30ea\u30b9\u30af\u7fa4\u306f\u3001\u4e00\u822c\u7684\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u958b\u59cb\u5e74\u9f62\u3088\u308a\u5e73\u574712.4\u5e74\u65e9\u304f\u540c\u7b49\u306e\u30ea\u30b9\u30af\u30ec\u30d9\u30eb\u306b\u9054\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u3001\u65e9\u671f\u4ecb\u5165\u306e\u91cd\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n

2. \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u7528\u3044\u305f\u75be\u60a3\u306e\u65e9\u671f\u8a3a\u65ad<\/strong><\/p>\n\n\n\n

\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u691c\u51fa\u306f\u3001\u75be\u60a3\u306e\u65e9\u671f\u8a3a\u65ad\u3084\u9032\u884c\u5ea6\u306e\u8a55\u4fa1\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u624b\u6bb5\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u6771\u4eac\u5de5\u696d\u5927\u5b66\u306e\u7814\u7a76\u3067\u306f\u3001DNA\u6db2\u6ef4\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u304c\u3093\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bmiRNA\u3092\u9ad8\u611f\u5ea6\u306b\u691c\u51fa\u3059\u308b\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u6280\u8853\u306f\u3001\u8907\u6570\u306emiRNA\u3092\u540c\u6642\u306b\u691c\u51fa\u3057\u3001\u304c\u3093\u306e\u65e9\u671f\u767a\u898b\u3084\u8a3a\u65ad\u306b\u6d3b\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 <\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

3. \u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u65b0\u305f\u306a\u8a3a\u65ad\u6cd5\u306e\u958b\u767a<\/strong><\/p>\n\n\n\n

\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u65e9\u671f\u8a3a\u65ad\u306b\u3082\u3001\u907a\u4f1d\u5b50\u3084\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u9806\u5929\u5802\u5927\u5b66\u306e\u7814\u7a76\u3067\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u306a\u3069\u306e\u60a3\u8005\u306e\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3059\u308b\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u30b7\u30fc\u30c9\u304c\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u8a3a\u65ad\u304a\u3088\u3073\u9451\u5225\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u767a\u898b\u306f\u3001\u8840\u6db2\u691c\u67fb\u306b\u3088\u308b\u7c21\u4fbf\u306a\u8a3a\u65ad\u65b9\u6cd5\u306e\u78ba\u7acb\u306b\u5411\u3051\u305f\u91cd\u8981\u306a\u4e00\u6b69\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

4. \u30b2\u30ce\u30e0\u533b\u7642\u306e\u63a8\u9032\u3068\u5b9f\u7528\u5316\u306b\u5411\u3051\u305f\u53d6\u308a\u7d44\u307f<\/strong><\/p>\n\n\n\n

\u65e5\u672c\u3067\u306f\u3001\u5168\u30b2\u30ce\u30e0\u89e3\u6790\u7b49\u306e\u6210\u679c\u3092\u5e83\u304f\u60a3\u8005\u306b\u9084\u5143\u3059\u308b\u305f\u3081\u3001\u7523\u5b66\u30b3\u30f3\u30bd\u30fc\u30b7\u30a2\u30e0\u3068\u9023\u643a\u3057\u305f\u53d6\u308a\u7d44\u307f\u304c\u63a8\u9032\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u5c0f\u5150\u304c\u3093\u3001\u5e0c\u5c11\u304c\u3093\u3001\u96e3\u6cbb\u6027\u304c\u3093\u306a\u3069\u306b\u5bfe\u3059\u308b\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3084\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u63a8\u9032\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u53d6\u308a\u7d44\u307f\u306f\u3001\u5168\u30b2\u30ce\u30e0\u89e3\u6790\u7b49\u306e\u6210\u679c\u3092\u533b\u7642\u73fe\u5834\u306b\u5c0e\u5165\u3057\u3001\u304c\u3093\u3084\u96e3\u75c5\u306e\u514b\u670d\u3092\u76ee\u6307\u3059\u3082\u306e\u3067\u3059\u3002 <\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

5. \u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u306b\u3088\u308b\u514d\u75ab\u75be\u60a3\u306e\u7406\u89e3<\/strong><\/p>\n\n\n\n

\u5927\u962a\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30b7\u30f3\u30b0\u30eb\u30bb\u30ebRNA\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u7528\u3044\u3066\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u75be\u60a3\u306b\u95a2\u3059\u308b\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u6210\u679c\u3092\u307e\u3068\u3081\u3001\u81e8\u5e8a\u5fdc\u7528\u3078\u306e\u8996\u70b9\u304b\u3089\u89e3\u8aac\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7dcf\u8aac\u3067\u306f\u3001\u75be\u60a3\u3054\u3068\u306b\u7d30\u80de\u96c6\u56e3\u306e\u5909\u5316\u3092\u7dcf\u62ec\u3057\u3001\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3084\u6cbb\u7642\u6a19\u7684\u3068\u306a\u308b\u60c5\u5831\u3092\u62bd\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u81a8\u5927\u306a\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u30c7\u30fc\u30bf\u3092\u6271\u3046\u4e0a\u3067\u3001\u60a3\u8005\u3092\u610f\u8b58\u3057\u305f\u81e8\u5e8a\u7684\u8996\u70b9\u306e\u91cd\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

6. \u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306b\u3088\u308b\u304c\u3093\u306e\u5305\u62ec\u7684\u89e3\u6790<\/strong><\/p>\n\n\n\n

\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306f\u3001\u304c\u3093\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u691c\u51fa\u3057\u3001\u5305\u62ec\u7684\u306a\u30b2\u30ce\u30e0\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u53d6\u5f97\u3059\u308b\u624b\u6cd5\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u6297\u60aa\u6027\u816b\u760d\u85ac\u306e\u9078\u629e\u3084\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u63a8\u9032\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

7. \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u7cbe\u88fd\u6cd5\u306e\u958b\u767a\u306b\u3088\u308b\u75be\u60a3\u306e\u65e9\u671f\u767a\u898b<\/strong><\/p>\n\n\n\n

\"\nMRI\u691c\u67fb17\"<\/figure>\n\n\n\n

\u75be\u60a3\u306b\u3088\u3063\u3066\u751f\u4f53\u5185\u306e\u5b58\u5728\u91cf\u304c\u5909\u5316\u3059\u308b\u7269\u8cea\u3092\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u547c\u3073\u3001\u3053\u308c\u3089\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u9ad8\u7cbe\u5ea6\u306b\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u7cbe\u88fd\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6280\u8853\u306f\u3001\u304c\u3093\u3084\u547c\u5438\u5668\u75be\u60a3\u3001\u795e\u7d4c\u75be\u60a3\u306a\u3069\u3001\u69d8\u3005\u306a\u75be\u60a3\u306e\u65e9\u671f\u767a\u898b\u306b\u5f79\u7acb\u3064\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

8. \u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u306e\u65b0\u898f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u767a\u898b<\/strong><\/p>\n\n\n\n

\u5e83\u5cf6\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001ALS\u60a3\u8005\u306e\u9aa8\u683c\u7b4b\u5185\u306b\u3042\u308b\u7b4b\u5185\u795e\u7d4c\u675f\u306b\u3001ALS\u306e\u75c5\u614b\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bTDP-43\u304c\u7570\u5e38\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u767a\u898b\u306f\u3001ALS\u306e\u65e9\u671f\u8a3a\u65ad\u3092\u53ef\u80fd\u3068\u3059\u308b\u65b0\u305f\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u5909\u7570\u3068\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u95a2\u9023\u6027<\/strong><\/h3>\n\n\n\n

\u751f\u6d3b\u7fd2\u6163\u75c5\u306f\u3001\u74b0\u5883\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u767a\u75c7\u30ea\u30b9\u30af\u304c\u5de6\u53f3\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u7cd6\u5c3f\u75c5\u3084\u9ad8\u8840\u5727\u3001\u8102\u8cea\u7570\u5e38\u75c7\u3068\u3044\u3063\u305f\u75be\u60a3\u306f\u3001\u591a\u56e0\u5b50\u907a\u4f1d\uff08\u8907\u6570\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3059\u308b\uff09\u306b\u3088\u308b\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

1. TCF7L2\u907a\u4f1d\u5b50\u3068\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af<\/strong><\/h4>\n\n\n\n

TCF7L2\uff08\u8ee2\u5199\u56e0\u5b507\u69d82\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5927\u304d\u304f\u5de6\u53f3\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\uff08rs7903146\uff09\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c2\u500d\u4ee5\u4e0a\u306b\u306a\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3042\u308b\u7814\u7a76\u3067\u306f\u3001TCF7L2\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u91cf\u304c\u4f4e\u4e0b\u3057\u3001\u8840\u7cd6\u5024\u306e\u8abf\u7bc0\u304c\u56f0\u96e3\u306b\u306a\u308b\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u767a\u898b\u306b\u3088\u308a\u3001\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u3005\u306b\u5bfe\u3057\u3066\u3001\u3088\u308a\u65e9\u3044\u6bb5\u968e\u3067\u98df\u4e8b\u7642\u6cd5\u3084\u904b\u52d5\u7642\u6cd5\u3092\u5c0e\u5165\u3059\u308b\u91cd\u8981\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

2. AGT\u907a\u4f1d\u5b50\u3068\u9ad8\u8840\u5727<\/strong><\/h4>\n\n\n\n

\u9ad8\u8840\u5727\u306e\u767a\u75c7\u306b\u306f\u3001\u814e\u81d3\u3067\u306e\u30ca\u30c8\u30ea\u30a6\u30e0\u30fb\u6c34\u5206\u30d0\u30e9\u30f3\u30b9\u3092\u8abf\u7bc0\u3059\u308b\u30db\u30eb\u30e2\u30f3\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u306e\u304c AGT\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\uff09\u907a\u4f1d\u5b50<\/strong> \u3067\u3059\u3002AGT\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\uff08M235T\uff09\u306f\u3001\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\u306e\u7523\u751f\u91cf\u3092\u5897\u52a0\u3055\u305b\u3001\u7d50\u679c\u3068\u3057\u3066\u8840\u5727\u3092\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u98df\u5869\u306e\u6442\u53d6\u91cf\u304c\u591a\u3044\u5834\u5408\u306b\u7279\u306b\u9ad8\u8840\u5727\u3092\u767a\u75c7\u3057\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u305f\u3081\u3001\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u306f\u6e1b\u5869\u3092\u5fc3\u304c\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

3. APOE\u907a\u4f1d\u5b50\u3068\u8102\u8cea\u7570\u5e38\u75c7<\/strong><\/h4>\n\n\n\n

APOE\uff08\u30a2\u30dd\u30ea\u30dd\u30d7\u30ed\u30c6\u30a4\u30f3E\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u7279\u306bE4\u30a2\u30ec\u30eb\u3092\u6301\u3064\u4eba\u306f\u8102\u8cea\u7570\u5e38\u75c7\u3084\u52d5\u8108\u786c\u5316\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

APOE\u306eE4\u578b\u3092\u6301\u3064\u4eba\u306f\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u60aa\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308a\u3084\u3059\u304f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001E2\u578b\u3092\u6301\u3064\u4eba\u306f\u9006\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u304f\u306a\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001E4\u30a2\u30ec\u30eb\u3092\u6301\u3064\u4eba\u304c\u98fd\u548c\u8102\u80aa\u9178\u3092\u591a\u304f\u6442\u53d6\u3059\u308b\u3068\u3001\u52d5\u8108\u786c\u5316\u306e\u9032\u884c\u304c\u52a0\u901f\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001APOE\u907a\u4f1d\u5b50\u306e\u30bf\u30a4\u30d7\u306b\u5fdc\u3058\u305f\u98df\u4e8b\u6307\u5c0e\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u898b\u76f4\u3057\u304c\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u9632\u306b\u5f79\u7acb\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\n\n\n\n

\u304c\u3093\u767a\u75c7\u30ea\u30b9\u30af\u3068\u907a\u4f1d\u5b50\u30de\u30fc\u30ab\u30fc<\/strong><\/h3>\n\n\n\n
\"\u4ecb\u8b77\u65bd\u8a2d\u3067\u66ae\u3089\u3059\u9ad8\u9f62\u8005\u5973\u6027\u3068\u533b\u5e2b\"<\/figure>\n\n\n\n

\u304c\u3093\u306f\u591a\u56e0\u5b50\u75be\u60a3\u3067\u3042\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u76f8\u4e92\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u65e9\u671f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3084\u4e88\u9632\u7b56\u306e\u7b56\u5b9a\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

1. BRCA1\/BRCA2\u907a\u4f1d\u5b50\u3068\u4e73\u304c\u3093\u30fb\u5375\u5de3\u304c\u3093<\/strong><\/h4>\n\n\n\n

BRCA1\u304a\u3088\u3073BRCA2\u907a\u4f1d\u5b50<\/strong> \u306e\u5909\u7570\u306f\u3001\u4e73\u304c\u3093\u304a\u3088\u3073\u5375\u5de3\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5927\u5e45\u306b\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001BRCA1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u306f\u300180\u6b73\u307e\u3067\u306b\u4e73\u304c\u3093\u3092\u767a\u75c7\u3059\u308b\u78ba\u7387\u304c50\uff5e70%\u306b\u9054\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u308c\u306b\u3088\u308a\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u4eba\u3005\u306f\u5b9a\u671f\u7684\u306aMRI\u691c\u67fb\u3084\u4e88\u9632\u7684\u4e73\u623f\u5207\u9664\u624b\u8853\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u306e\u767a\u75c7\u3092\u56de\u907f\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

2. TP53\u907a\u4f1d\u5b50\u3068\u304c\u3093\u5168\u822c<\/strong><\/h4>\n\n\n\n

TP53\uff08\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\uff09<\/strong> \u306f\u3001DNA\u640d\u50b7\u3092\u4fee\u5fa9\u3057\u3001\u7d30\u80de\u306e\u7570\u5e38\u5897\u6b96\u3092\u9632\u3050\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u751f\u3058\u308b\u3068\u3001\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u5927\u5e45\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7279\u306b\u3001TP53\u306e\u5909\u7570\u306f\u30ea\u30fb\u30d5\u30e9\u30a6\u30e1\u30cb\u75c7\u5019\u7fa4\u3068\u3044\u3046\u907a\u4f1d\u6027\u304c\u3093\u75c7\u5019\u7fa4\u306b\u95a2\u9023\u3057\u3001\u4e73\u304c\u3093\u3001\u767d\u8840\u75c5\u3001\u8133\u816b\u760d\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\n\n\n\n

\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u75be\u60a3\u306e\u4e88\u9632\u3068\u6cbb\u7642<\/strong><\/h3>\n\n\n\n

\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u7279\u5b9a\u3055\u308c\u305f\u5834\u5408\u3001\u305d\u306e\u5909\u7570\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u3067\u75be\u60a3\u306e\u767a\u75c7\u3092\u9632\u3050\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001CRISPR-Cas9<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306f\u3001\u75be\u60a3\u30ea\u30b9\u30af\u3092\u6301\u3064\u907a\u4f1d\u5b50\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u52a0\u901f\u3055\u305b\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

1. CRISPR-Cas9\u306b\u3088\u308b\u907a\u4f1d\u6027\u75be\u60a3\u306e\u6cbb\u7642<\/strong><\/h4>\n\n\n\n

CRISPR-Cas9\u306f\u3001\u7279\u5b9a\u306eDNA\u914d\u5217\u3092\u5207\u65ad\u30fb\u4fee\u6b63\u3067\u304d\u308b\u6280\u8853\u3067\u3042\u308a\u3001\u907a\u4f1d\u6027\u75be\u60a3\u306e\u6839\u672c\u7684\u306a\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001\u938c\u72b6\u8d64\u8840\u7403\u75c7\u306e\u539f\u56e0\u907a\u4f1d\u5b50\uff08HBB\u907a\u4f1d\u5b50\uff09\u306e\u5909\u7570\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u3067\u3001\u75c7\u72b6\u3092\u6839\u672c\u7684\u306b\u6539\u5584\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u907a\u4f1d\u6027\u306e\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u306b\u5bfe\u3057\u3066\u3082\u3001CRISPR\u6280\u8853\u3092\u7528\u3044\u305f\u6cbb\u7642\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u7b4b\u8089\u306e\u518d\u751f\u304c\u78ba\u8a8d\u3055\u308c\u308b\u306a\u3069\u3001\u5b9f\u7528\u5316\u306b\u5411\u3051\u305f\u9032\u5c55\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

2. \u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u73fe\u72b6\u3068\u672a\u6765<\/strong><\/h4>\n\n\n\n

\u73fe\u5728\u3001\u7c73\u56fdFDA\u306f\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u627f\u8a8d\u3092\u62e1\u5927\u3057\u3066\u304a\u308a\u3001\u907a\u4f1d\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u9769\u65b0\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5b9f\u73fe\u3057\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\uff08SMA\uff09\u306e\u6cbb\u7642\u85ac Zolgensma<\/strong> \u306f\u30011\u56de\u306e\u6295\u4e0e\u3067\u6839\u672c\u6cbb\u7642\u3092\u76ee\u6307\u3059\u907a\u4f1d\u5b50\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u75be\u60a3\u306e\u4e88\u9632\u30fb\u8a3a\u65ad\u30fb\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u304c\u5927\u304d\u304f\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306e\u6280\u8853\u9769\u65b0\u306b\u3088\u308a\u3001\u3088\u308a\u591a\u304f\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u500b\u5225\u5316\u533b\u7642\u304c\u5b9f\u73fe\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u7cfb\u306e\u95a2\u4fc2\uff1a\u611f\u67d3\u75c7\u3078\u306e\u611f\u53d7\u6027\u3068\u9632\u5fa1\u529b<\/strong><\/h3>\n\n\n\n
\"\n\u30de\u30b9\u30af\u3092\u3064\u3051\u308b\u5973\u6027\u3000\u611f\u67d3\u5bfe\u7b56\"<\/figure>\n\n\n\n

\u514d\u75ab\u7cfb\u306f\u3001\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u69cb\u6210\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b\u8981\u7d20\u306e\u4e00\u3064\u3067\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u307e\u308b\u4e00\u65b9\u3067\u3001\u9006\u306b\u611f\u67d3\u75c7\u3078\u306e\u8010\u6027\u3092\u6301\u3064\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u3092\u542b\u3080\u611f\u67d3\u75c7\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u3084\u56de\u5fa9\u529b\u306b\u3082\u3001\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

1. HLA\u907a\u4f1d\u5b50\u3068\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3078\u306e\u611f\u53d7\u6027<\/strong><\/h4>\n\n\n\n

HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308a\u3001\u7279\u5b9a\u306eHLA\u30bf\u30a4\u30d7\u3092\u6301\u3064\u4eba\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306b\u5bfe\u3057\u3066\u5f37\u3044\u514d\u75ab\u53cd\u5fdc\u3092\u793a\u3059\u4e00\u65b9\u3067\u3001\u5225\u306eHLA\u30bf\u30a4\u30d7\u3092\u6301\u3064\u4eba\u306f\u91cd\u75c7\u5316\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4f8b\u3048\u3070\u3001COVID-19\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u306f\u3001HLA-B46:01\u3092\u6301\u3064\u4eba\u306f\u514d\u75ab\u5fdc\u7b54\u304c\u5f31\u304f\u3001\u611f\u67d3\u5f8c\u306b\u91cd\u75c7\u5316\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001HLA-B<\/em>15:03\u3092\u6301\u3064\u4eba\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u3092\u8fc5\u901f\u306b\u6392\u9664\u3067\u304d\u308b\u305f\u3081\u3001\u8efd\u75c7\u3067\u6e08\u3080\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001HLA\u907a\u4f1d\u5b50\u306e\u30bf\u30a4\u30d7\u3092\u4e8b\u524d\u306b\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u611f\u67d3\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u9069\u5207\u306a\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

2. IFITM3\u907a\u4f1d\u5b50\u3068\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u91cd\u75c7\u5316\u30ea\u30b9\u30af<\/strong><\/h4>\n\n\n\n

IFITM3\uff08\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u8a98\u5c0e\u30c8\u30e9\u30f3\u30b9\u30e1\u30f3\u30d6\u30e9\u30f3\u30bf\u30f3\u30d1\u30af\u8cea3\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u7d30\u80de\u306b\u4fb5\u5165\u3059\u308b\u306e\u3092\u9632\u3050\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\uff08rs12252-C\/C\uff09\u304c\u3042\u308b\u3068\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u3078\u306e\u9632\u5fa1\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u91cd\u75c7\u5316\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u5b9f\u969b\u3001H1N1\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u6642\u306b\u306f\u3001\u91cd\u75c7\u60a3\u8005\u306e\u591a\u304f\u304c\u3053\u306e\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u305f\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001IFITM3\u306e\u907a\u4f1d\u5b50\u578b\u304c\u611f\u67d3\u75c7\u306e\u91cd\u75c7\u5ea6\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u306e\u77e5\u898b\u306f\u3001\u500b\u5225\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u611f\u67d3\u75c7\u4e88\u9632\u7b56\u306e\u7b56\u5b9a\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u8178\u5185\u7d30\u83cc\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\uff1a\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u304c\u75c5\u6c17\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n

\u8178\u5185\u7d30\u83cc\uff08\u8178\u5185\u30d5\u30ed\u30fc\u30e9\uff09\u306e\u69cb\u6210\u306f\u3001\u500b\u4eba\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3042\u308b\u7a0b\u5ea6\u6c7a\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u514d\u75ab\u7cfb\u3084\u4ee3\u8b1d\u7cfb\u3001\u3055\u3089\u306b\u306f\u7cbe\u795e\u7684\u5065\u5eb7\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

1. FUT2\u907a\u4f1d\u5b50\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u69cb\u6210<\/strong><\/h4>\n\n\n\n

FUT2\uff08\u30d5\u30b3\u30fc\u30b9\u8ee2\u79fb\u9175\u7d202\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8178\u5185\u7d30\u83cc\u306e\u5b9a\u7740\u306b\u95a2\u4e0e\u3057\u3001\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u3068\u8178\u5185\u74b0\u5883\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002FUT2\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\uff08\u300c\u30ce\u30f3\u30b7\u30fc\u30af\u30ec\u30bf\u30fc\u300d\u3068\u547c\u3070\u308c\u308b\uff09\u306f\u3001\u8178\u5185\u306e\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306e\u5272\u5408\u304c\u4f4e\u304f\u3001\u6d88\u5316\u5668\u7cfb\u306e\u611f\u67d3\u75c7\u306b\u304b\u304b\u308a\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u30ce\u30f3\u30b7\u30fc\u30af\u30ec\u30bf\u30fc\u306e\u4eba\u306f\u30af\u30ed\u30b9\u30c8\u30ea\u30b8\u30a6\u30e0\u30fb\u30c7\u30a3\u30d5\u30a3\u30b7\u30eb\u611f\u67d3\u75c7\uff08CDI\uff09\u306e\u30ea\u30b9\u30af\u304c2\u500d\u4ee5\u4e0a\u9ad8\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u304c\u611f\u67d3\u75c7\u306e\u4e88\u9632\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u6442\u53d6\u3084\u98df\u751f\u6d3b\u306e\u6539\u5584\u306b\u3088\u3063\u3066\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

2. TLR4\u907a\u4f1d\u5b50\u3068\u8178\u5185\u708e\u75c7<\/strong><\/h4>\n\n\n\n
\"\n\u5bb6\u306b\u3044\u308b\u9ad8\u9f62\u8005\u306e\u7537\u6027\uff08\u304a\u8179\uff09\"<\/figure>\n\n\n\n

TLR4\uff08\u30c8\u30eb\u69d8\u53d7\u5bb9\u4f534\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8178\u5185\u306e\u75c5\u539f\u83cc\u3092\u691c\u77e5\u3057\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u6d3b\u6027\u5316\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u514d\u75ab\u5fdc\u7b54\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3055\u308c\u3001\u6162\u6027\u7684\u306a\u8178\u5185\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u6f70\u760d\u6027\u5927\u8178\u708e\u3084\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u60a3\u8005\u3067\u306f\u3001TLR4\u306e\u5909\u7570\u7387\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u8178\u5185\u306e\u514d\u75ab\u53cd\u5fdc\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0\u306e\u4e00\u3064\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u306e\u7814\u7a76\u306f\u3001\u8178\u5185\u74b0\u5883\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u305f\u9069\u5207\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u7cbe\u795e\u75be\u60a3\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u9023\u6027\uff1a\u907a\u4f1d\u5b50\u304c\u793a\u3059\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u30ea\u30b9\u30af<\/strong><\/h3>\n\n\n\n

\u7cbe\u795e\u75be\u60a3\u306f\u3001\u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u7684\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u7d71\u5408\u5931\u8abf\u75c7\u3001\u53cc\u6975\u6027\u969c\u5bb3\u3001\u3046\u3064\u75c5\u306a\u3069\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u304c\u7279\u5b9a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

1. COMT\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h4>\n\n\n\n

COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30c9\u30fc\u30d1\u30df\u30f3\u3084\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\uff09\u306e\u5206\u89e3\u306b\u95a2\u4e0e\u3057\u3001\u7cbe\u795e\u7684\u306a\u8010\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u907a\u4f1d\u5b50\u306b\u306fVal\/Met\u591a\u578b\u304c\u5b58\u5728\u3057\u3001Val\u578b\u3092\u6301\u3064\u4eba\u306f\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8010\u6027\u304c\u9ad8\u3044\u50be\u5411\u304c\u3042\u308a\u3001Met\u578b\u3092\u6301\u3064\u4eba\u306f\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u4e0d\u5b89\u969c\u5bb3\u3084\u3046\u3064\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u500b\u4eba\u306e\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u8a55\u4fa1\u3057\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u30b1\u30a2\u3092\u6700\u9069\u5316\u3059\u308b\u305f\u3081\u306e\u6307\u6a19\u3068\u3057\u3066\u6d3b\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

2. BDNF\u907a\u4f1d\u5b50\u3068\u3046\u3064\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af<\/strong><\/h4>\n\n\n\n

BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3068\u53ef\u5851\u6027\u3092\u4fc3\u9032\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001BDNF\u306e\u7279\u5b9a\u306e\u5909\u7570\uff08Val66Met\uff09\u304c\u3042\u308b\u3068\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u3046\u3064\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3042\u308b\u7814\u7a76\u3067\u306f\u3001BDNF\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30d5\u30eb\u306a\u74b0\u5883\u306b\u7f6e\u304b\u308c\u305f\u969b\u306b\u3001\u6291\u3046\u3064\u75c7\u72b6\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u7684\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u7cbe\u795e\u75be\u60a3\u306e\u767a\u75c7\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u304c\u7cbe\u795e\u7684\u306a\u5065\u5eb7\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u3001\u4eca\u5f8c\u306f\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u7cbe\u795e\u533b\u7642\u306e\u767a\u5c55\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\u907a\u4f1d\u5b50\u3068\u7761\u7720\uff1a\u4f53\u5185\u6642\u8a08\u304c\u5065\u5eb7\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n

\u7761\u7720\u306e\u8cea\u3084\u30ea\u30ba\u30e0\u306f\u3001\u74b0\u5883\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u6982\u65e5\u30ea\u30ba\u30e0\uff08\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\uff09<\/strong> \u3092\u8abf\u6574\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u304c\u3001\u7761\u7720\u969c\u5bb3\u3084\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

1. PER3\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u8cea<\/strong><\/h4>\n\n\n\n
\"\n\u3042\u304f\u3073\u3092\u3059\u308b\u30d3\u30b8\u30cd\u30b9\u30de\u30f3\"<\/figure>\n\n\n\n

PER3\uff08Period Circadian Regulator 3\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u305d\u306e\u9577\u3055\u304c\u7761\u7720\u306e\u8cea\u3084\u30d1\u30bf\u30fc\u30f3\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002PER3\u907a\u4f1d\u5b50\u306b\u306f\u9577\u3044\u578b\uff08PER3 5\/5\uff09\u3068\u77ed\u3044\u578b\uff08PER3 4\/4\uff09\u304c\u3042\u308a\u3001\u907a\u4f1d\u7684\u306bPER3 5\/5\u3092\u6301\u3064\u4eba\u306f\u3001\u65e9\u5bdd\u65e9\u8d77\u304d\u306e\u50be\u5411\u304c\u5f37\u304f\u3001\u6df1\u3044\u7761\u7720\u3092\u3068\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001PER3 4\/4\u3092\u6301\u3064\u4eba\u306f\u591c\u578b\u306e\u50be\u5411\u304c\u3042\u308a\u3001\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001PER3\u907a\u4f1d\u5b50\u306e\u77ed\u7e2e\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u6162\u6027\u7684\u306a\u7761\u7720\u4e0d\u8db3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3084\u6c17\u5206\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

2. CLOCK\u907a\u4f1d\u5b50\u3068\u4f53\u5185\u6642\u8a08\u306e\u4e71\u308c<\/strong><\/h4>\n\n\n\n

CLOCK\uff08Circadian Locomotor Output Cycles Kaput\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u4f53\u5185\u6642\u8a08\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u4e71\u308c\u3068\u7761\u7720\u969c\u5bb3\u306e\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u9045\u5bdd\u9045\u8d77\u304d\u306e\u50be\u5411\u304c\u5f37\u307e\u308a\u3001\u793e\u4f1a\u7684\u6642\u5dee\u307c\u3051\uff08Social Jetlag\uff09\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u7279\u306b\u3001rs1801260\u3068\u3044\u3046SNP\uff08\u5358\u5869\u57fa\u591a\u578b\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u30ba\u30ec\u304c\u5927\u304d\u304f\u3001\u30b7\u30d5\u30c8\u30ef\u30fc\u30af\uff08\u591c\u52e4\uff09\u306a\u3069\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u3092\u6301\u3064\u4eba\u306f\u3001\u898f\u5247\u7684\u306a\u7761\u7720\u7fd2\u6163\u3092\u5fc3\u304c\u3051\u308b\u3053\u3068\u3067\u3001\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

3. MTNR1B\u907a\u4f1d\u5b50\u3068\u30e1\u30e9\u30c8\u30cb\u30f3\u5206\u6ccc<\/strong><\/h4>\n\n\n\n

MTNR1B\uff08\u30e1\u30e9\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f531B\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u3068\u3044\u3046\u7761\u7720\u30db\u30eb\u30e2\u30f3\u306e\u50cd\u304d\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u304c\u9045\u308c\u3001\u591c\u66f4\u304b\u3057\u306e\u50be\u5411\u304c\u5f37\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001MTNR1B\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3068\u3082\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u4e71\u308c\u304c\u8840\u7cd6\u5024\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u907a\u4f1d\u7684\u306b\u591c\u578b\u306e\u50be\u5411\u3092\u6301\u3064\u4eba\u304c\u3001\u8840\u7cd6\u5024\u306e\u7ba1\u7406\u3092\u610f\u8b58\u3059\u308b\u3053\u3068\u3067\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n

\u904b\u52d5\u80fd\u529b\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\uff1a\u30b9\u30dd\u30fc\u30c4\u9069\u6027\u306e\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n

\u904b\u52d5\u80fd\u529b\u306f\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3060\u3051\u3067\u306a\u304f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u8fd1\u5e74\u306e\u30b2\u30ce\u30e0\u7814\u7a76\u3067\u306f\u3001ACTN3<\/strong> \u3084 ACE<\/strong> \u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u30b9\u30dd\u30fc\u30c4\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

1. ACTN3\u907a\u4f1d\u5b50\u3068\u7b4b\u7e4a\u7dad\u306e\u30bf\u30a4\u30d7<\/strong><\/h4>\n\n\n\n

ACTN3\uff08\u30a2\u30eb\u30d5\u30a1\u30a2\u30af\u30c1\u30cb\u30f33\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u901f\u7b4b\u7e4a\u7dad\uff08\u30d5\u30a1\u30b9\u30c8\u30c4\u30a4\u30c3\u30c1\u7b4b\uff09\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u77ed\u8ddd\u96e2\u8d70\u3084\u30d1\u30ef\u30fc\u7cfb\u30b9\u30dd\u30fc\u30c4\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u5de6\u53f3\u3059\u308b\u8981\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

ACTN3\u907a\u4f1d\u5b50\u306b\u306f\u300cRR\u578b\u300d\u300cRX\u578b\u300d\u300cXX\u578b\u300d\u306e3\u7a2e\u985e\u304c\u3042\u308a\u3001RR\u578b\u306e\u4eba\u306f\u901f\u7b4b\u306e\u5272\u5408\u304c\u9ad8\u304f\u3001\u77ac\u767a\u529b\u3092\u5fc5\u8981\u3068\u3059\u308b\u30b9\u30dd\u30fc\u30c4\u306b\u9069\u6027\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001XX\u578b\u306e\u4eba\u306f\u901f\u7b4b\u306e\u767a\u9054\u304c\u5f31\u304f\u3001\u6301\u4e45\u7cfb\u30b9\u30dd\u30fc\u30c4\u306b\u5411\u3044\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

2. ACE\u907a\u4f1d\u5b50\u3068\u6301\u4e45\u529b<\/strong><\/h4>\n\n\n\n

ACE\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u5fc3\u8840\u7ba1\u6a5f\u80fd\u3084\u6301\u4e45\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002ACE\u907a\u4f1d\u5b50\u306b\u306f\u300cI\u578b\u300d\u300cD\u578b\u300d\u306e\u591a\u578b\u304c\u3042\u308a\u3001I\u578b\u3092\u6301\u3064\u4eba\u306f\u6301\u4e45\u529b\u306b\u512a\u308c\u3001D\u578b\u3092\u6301\u3064\u4eba\u306f\u77ed\u8ddd\u96e2\u7cfb\u306e\u30d1\u30ef\u30fc\u30b9\u30dd\u30fc\u30c4\u306b\u5411\u3044\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30de\u30e9\u30bd\u30f3\u9078\u624b\u3084\u30c8\u30e9\u30a4\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u591a\u304f\u306fACE I\u578b\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u6301\u4e45\u529b\u5411\u4e0a\u306b\u95a2\u4e0e\u3059\u308b\u8981\u7d20\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

3. MSTN\u907a\u4f1d\u5b50\u3068\u7b4b\u8089\u306e\u6210\u9577<\/strong><\/h4>\n\n\n\n
\"\n\u5c4b\u5916\u3067\u8179\u7b4b\u3059\u308b\u7537\u6027\"<\/figure>\n\n\n\n

MSTN\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u7b4b\u8089\u306e\u6210\u9577\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u7b4b\u8089\u91cf\u304c\u5897\u52a0\u3057\u3084\u3059\u304f\u3001\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c\u304c\u5927\u304d\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u5b9f\u969b\u3001MSTN\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u4e00\u822c\u7684\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u3082\u7b4b\u80a5\u5927\u306e\u901f\u5ea6\u304c\u901f\u304f\u3001\u30a6\u30a7\u30a4\u30c8\u30ea\u30d5\u30c6\u30a3\u30f3\u30b0\u3084\u30dc\u30c7\u30a3\u30d3\u30eb\u30c7\u30a3\u30f3\u30b0\u306b\u9069\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n

\u3053\u308c\u3089\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u500b\u4eba\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u306b\u5fdc\u3058\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u3067\u3001\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u306f\u7761\u7720\u306e\u8cea\u3084\u904b\u52d5\u80fd\u529b\u306b\u3082\u6df1\u304f\u95a2\u308f\u3063\u3066\u304a\u308a\u3001\u500b\u4eba\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u9078\u629e\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u3084\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u304c\u3055\u3089\u306b\u9032\u5c55\u3057\u3001\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u3084\u5065\u5eb7\u7ba1\u7406\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n\n\n\n

\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n

\u907a\u4f1d\u5b50\u306f\u3001\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3001\u514d\u75ab\u5fdc\u7b54\u3001\u7761\u7720\u3001\u904b\u52d5\u80fd\u529b\u306a\u3069\u3001\u591a\u304f\u306e\u5065\u5eb7\u8981\u56e0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u75be\u60a3\u306e\u767a\u75c7\u3084\u91cd\u75c7\u5316\u3092\u5de6\u53f3\u3057\u3001\u65e9\u671f\u8a3a\u65ad\u3084\u4e88\u9632\u306b\u6d3b\u7528\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u7761\u7720\u3084\u4f53\u5185\u6642\u8a08\u3001\u30b9\u30dd\u30fc\u30c4\u9069\u6027\u306b\u3082\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3001\u500b\u5225\u5316\u533b\u7642\u3084\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6700\u9069\u5316\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u7cbe\u5bc6\u306a\u5065\u5eb7\u7ba1\u7406\u304c\u5e83\u304c\u308a\u3001\u500b\u4eba\u306b\u6700\u9069\u306a\u533b\u7642\u30fb\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u9078\u629e\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\n <\/p>\n
\n

\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e\u6700\u65b0\u6280\u8853<\/span><\/p>\n

\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n

<\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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