{"id":10362,"date":"2025-03-19T03:14:08","date_gmt":"2025-03-19T03:14:08","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10362"},"modified":"2025-03-19T03:14:10","modified_gmt":"2025-03-19T03:14:10","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e9%aa%a8%e3%81%ae%e5%81%a5%e5%ba%b7%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e7%b4%a0%e3%81%8c%e5%8f%8a%e3%81%bc%e3%81%99%e5%bd%b1%e9%9f%bf","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e9%aa%a8%e3%81%ae%e5%81%a5%e5%ba%b7%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e7%b4%a0%e3%81%8c%e5%8f%8a%e3%81%bc%e3%81%99%e5%bd%b1%e9%9f%bf\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u9aa8\u306e\u5065\u5eb7\uff1a\u907a\u4f1d\u7684\u8981\u7d20\u304c\u53ca\u307c\u3059\u5f71\u97ff"},"content":{"rendered":"\n<p>\u9aa8\u306e\u5065\u5eb7\u306f\u3001\u6211\u3005\u306e\u5168\u4f53\u7684\u306a\u5065\u5eb7\u72b6\u614b\u3084\u751f\u6d3b\u306e\u8cea\u306b\u76f4\u7d50\u3057\u3066\u3044\u307e\u3059\u3002\u9aa8\u7c97\u9b06\u75c7\u306a\u3069\u306e\u9aa8\u95a2\u9023\u75be\u60a3\u306f\u3001\u9ad8\u9f62\u5316\u793e\u4f1a\u306b\u304a\u3044\u3066\u307e\u3059\u307e\u3059\u91cd\u8981\u306a\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u306f\u3001\u74b0\u5883\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3082\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u9aa8\u306e\u5065\u5eb7\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3001\u6700\u65b0\u306e\u7814\u7a76\u7d50\u679c\u3092\u4ea4\u3048\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-16354dda-7fff-cf01-fb75-a4aa0140c9e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9aa8\u7c97\u9b06\u75c7\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u9aa8\u7c97\u9b06\u75c7\u306f\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3068\u9aa8\u7d44\u7e54\u306e\u52a3\u5316\u306b\u3088\u308a\u3001\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u75be\u60a3\u3067\u3059\u3002\u65e5\u672c\u3067\u306f\u300150\u6b73\u4ee5\u4e0a\u306e\u5973\u6027\u306e\u7d043\u4eba\u306b1\u4eba\u304c\u9aa8\u7c97\u9b06\u75c7\u3092\u767a\u75c7\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u75be\u60a3\u306e\u767a\u75c7\u306b\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u3084\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306a\u3069\u306e\u74b0\u5883\u8981\u56e0\u306b\u52a0\u3048\u3066\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>SH3BP2\u907a\u4f1d\u5b50\u306e\u5f79\u5272<\/strong><\/h4>\n\n\n\n<p><strong>SH3BP2<\/strong>\uff08SH3\u30c9\u30e1\u30a4\u30f3\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea2\uff09\u306f\u3001\u9aa8\u4ee3\u8b1d\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30a2\u30c0\u30d7\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u907a\u4f1d\u6027\u9aa8\u75be\u60a3\u3067\u3042\u308b\u30c1\u30a7\u30eb\u30d3\u30ba\u30e0\u306e\u539f\u56e0\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30c1\u30a7\u30eb\u30d3\u30ba\u30e0\u306f\u3001\u5e7c\u5150\u671f\u306b\u767a\u75c7\u3057\u3001\u9854\u9762\u9aa8\u306e\u708e\u75c7\u3084\u5909\u5f62\u3092\u7279\u5fb4\u3068\u3059\u308b\u75be\u60a3\u3067\u3059\u3002SH3BP2\u306f\u3001\u9aa8\u82bd\u7d30\u80de\u3084\u7834\u9aa8\u7d30\u80de\u306e\u5206\u5316\u3068\u6a5f\u80fd\u306b\u5fc5\u9808\u306e\u56e0\u5b50\u3067\u3042\u308a\u3001\u305d\u306e\u5909\u7570\u306f\u9aa8\u4ee3\u8b1d\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u5d29\u3057\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u767a\u75c7\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 <\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>FONG\u907a\u4f1d\u5b50\u306e\u767a\u898b<\/strong><\/h4>\n\n\n\n<p>\u7406\u5316\u5b66\u7814\u7a76\u6240\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u65b0\u305f\u306a\u907a\u4f1d\u5b50<strong>FONG<\/strong>\u304c\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u76f8\u95a2\u89e3\u6790\u306b\u3088\u308a\u30012\u756a\u67d3\u8272\u4f53\u9577\u8155\u4e0a\u306eSNP\u3067\u3042\u308brs7605378\u304c\u9aa8\u7c97\u9b06\u75c7\u3068\u5f37\u304f\u76f8\u95a2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306eSNP\u5468\u8fba\u306b\u306f\u65e2\u77e5\u306e\u907a\u4f1d\u5b50\u304c\u5b58\u5728\u3057\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u65b0\u305f\u306bFONG\u907a\u4f1d\u5b50\u304c\u767a\u898b\u3055\u308c\u3001\u305d\u306e\u6a5f\u80fd\u89e3\u660e\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff08VDR\uff09\u907a\u4f1d\u5b50\u3068\u9aa8\u5bc6\u5ea6<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u3092\u4fc3\u9032\u3057\u3001\u9aa8\u306e\u5f62\u6210\u3068\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u6804\u990a\u7d20\u3067\u3059\u3002<strong>\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\uff08VDR\uff09\u907a\u4f1d\u5b50<\/strong>\u306e\u591a\u578b\u306f\u3001\u9aa8\u5bc6\u5ea6\u306e\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306eVDR\u907a\u4f1d\u5b50\u591a\u578b\u3092\u6301\u3064\u500b\u4eba\u306f\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 citeturn0search6<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>HLA\u907a\u4f1d\u5b50\u3068\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1<\/strong><\/h3>\n\n\n\n<p><strong>HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50<\/strong>\u306f\u3001\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308b\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff08RA\uff09\u306e\u767a\u75c7\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002HLA\u907a\u4f1d\u5b50\u306f\u3001RA\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306e\u7d0430\uff05\u3092\u5360\u3081\u308b\u3068\u3055\u308c\u3001\u7279\u5b9a\u306eHLA\u30bf\u30a4\u30d7\u3092\u6301\u3064\u4eba\u306f\u3001RA\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u500b\u5225\u5316\u533b\u7642\u306e\u53ef\u80fd\u6027<\/strong><\/h3>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306e\u89e3\u660e\u306f\u3001\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u57fa\u3065\u304f\u4e88\u9632\u7b56\u3084\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u5224\u660e\u3057\u305f\u5834\u5408\u3001\u65e9\u671f\u304b\u3089\u306e\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3084\u9069\u5207\u306a\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u3001\u5b9a\u671f\u7684\u306a\u9aa8\u5bc6\u5ea6\u691c\u67fb\u306e\u5b9f\u65bd\u306a\u3069\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u4e88\u9632\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u6cbb\u7642\u6cd5\u3084\u85ac\u5264\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u6027\u3092\u4e88\u6e2c\u3057\u3001\u6700\u9069\u306a\u6cbb\u7642\u8a08\u753b\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u6cbb\u7642\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3057\u3001\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u3092\u6700\u5c0f\u5316\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9aa8\u306e\u6210\u9577\u3068\u767a\u9054\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/28871795_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9084\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28871795_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28871795_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28871795_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28871795_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/28871795_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9aa8\u306e\u6210\u9577\u3068\u767a\u9054\u306f\u3001\u5e7c\u5c11\u671f\u304b\u3089\u6210\u4eba\u671f\u306b\u304b\u3051\u3066\u591a\u304f\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3059\u308b\u8907\u96d1\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u3002\u7279\u306b\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u3084\u9aa8\u306e\u5f62\u6210\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u304c\u3001\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u306e\u5f37\u5ea6\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. COL1A1\u907a\u4f1d\u5b50\u3068\u9aa8\u5bc6\u5ea6<\/strong><\/h4>\n\n\n\n<p><strong>COL1A1\uff08\u30b3\u30e9\u30fc\u30b2\u30f3I\u578b\u03b11\u9396\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u9aa8\u306e\u4e3b\u8981\u306a\u69cb\u6210\u8981\u7d20\u3067\u3042\u308bI\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\uff08rs1800012\uff09\u306f\u3001\u9aa8\u5bc6\u5ea6\u306e\u6e1b\u5c11\u3084\u9aa8\u6298\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001rs1800012\u306eG\u7b49\u4f4d\u4f53\u3092\u6301\u3064\u500b\u4eba\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5408\u6210\u304c\u6e1b\u5c11\u3057\u3001\u9aa8\u306e\u5f37\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-69072-2\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u3092\u610f\u8b58\u3059\u308b\u3053\u3068\u3067\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. RUNX2\u907a\u4f1d\u5b50\u3068\u9aa8\u82bd\u7d30\u80de\u306e\u5f62\u6210<\/strong><\/h4>\n\n\n\n<p><strong>RUNX2\uff08Runt\u95a2\u9023\u8ee2\u5199\u56e0\u5b502\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u9aa8\u82bd\u7d30\u80de\u306e\u5206\u5316\u3092\u5236\u5fa1\u3057\u3001\u9aa8\u306e\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002RUNX2\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u9aa8\u306e\u6210\u9577\u304c\u9045\u308c\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001RUNX2\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u9aa8\u7c97\u9b06\u75c7\u3084\u4f4e\u9aa8\u91cf\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u9aa8\u6298\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.cell.com\/fulltext\/S0092-8674(14)00120-5\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u6b63\u5e38\u306b\u50cd\u304f\u305f\u3081\u306b\u306f\u3001\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3084\u4e9c\u925b\u3068\u3044\u3063\u305f\u30df\u30cd\u30e9\u30eb\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u98df\u4e8b\u306b\u3088\u308b\u88dc\u7d66\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. FGFR3\u907a\u4f1d\u5b50\u3068\u8edf\u9aa8\u306e\u767a\u9054<\/strong><\/h4>\n\n\n\n<p><strong>FGFR3\uff08\u7dda\u7dad\u82bd\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u53d7\u5bb9\u4f533\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u9aa8\u7aef\u8edf\u9aa8\u306e\u767a\u9054\u306b\u95a2\u4e0e\u3057\u3001\u6210\u9577\u904e\u7a0b\u3067\u9aa8\u306e\u9577\u3055\u3092\u6c7a\u5b9a\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u751f\u3058\u308b\u3068\u3001\u8edf\u9aa8\u306e\u6210\u9577\u304c\u7570\u5e38\u306b\u306a\u308a\u3001\u4f4e\u8eab\u9577\u75c7\u3084\u9aa8\u5f62\u6210\u7570\u5e38\u75c7\uff08\u8edf\u9aa8\u7121\u5f62\u6210\u75c7\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001FGFR3\u306e\u7279\u5b9a\u306e\u5909\u7570\uff08G380R\uff09\u304c\u8edf\u9aa8\u7d30\u80de\u306e\u5897\u6b96\u3092\u6291\u5236\u3057\u3001\u9aa8\u306e\u6210\u9577\u3092\u5236\u9650\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2056-2\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u9aa8\u306e\u6210\u9577\u7570\u5e38\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30db\u30eb\u30e2\u30f3\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u304c\u9aa8\u306e\u5065\u5eb7\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u9aa8\u306e\u5065\u5eb7\u306f\u3001\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306b\u3088\u3063\u3066\u3082\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u7279\u306b\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3084\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff08PTH\uff09\u306f\u3001\u9aa8\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\uff08\u9aa8\u306e\u518d\u69cb\u7bc9\uff09\u306b\u95a2\u4e0e\u3057\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u305d\u306e\u8abf\u7bc0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. ESR1\u907a\u4f1d\u5b50\u3068\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u611f\u53d7\u6027<\/strong><\/h4>\n\n\n\n<p><strong>ESR1\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u03b1\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u50cd\u304d\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u9aa8\u4fdd\u8b77\u4f5c\u7528\u304c\u5f31\u307e\u308a\u3001\u9589\u7d4c\u5f8c\u306e\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u304c\u52a0\u901f\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u3067\u306f\u3001ESR1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\uff08rs4870044\uff09\u304c\u3001\u9aa8\u6298\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.jci.org\/articles\/view\/142254\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u4f5c\u7528\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u9069\u5ea6\u306a\u904b\u52d5\u3084\u30d3\u30bf\u30df\u30f3K2\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. PTH\u907a\u4f1d\u5b50\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u4ee3\u8b1d<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9777\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30532404_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>PTH\uff08\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8840\u4e2d\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3057\u3001\u9aa8\u5438\u53ce\u3068\u9aa8\u5f62\u6210\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002PTH\u306e\u904e\u5270\u306a\u5206\u6ccc\u306f\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>PTH\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs1459015\uff09\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u52b9\u7387\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u9aa8\u4ee3\u8b1d\u7570\u5e38\u306e\u539f\u56e0\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2008027\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30d3\u30bf\u30df\u30f3D\u306e\u9069\u5207\u306a\u6442\u53d6\u304c\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-16354dda-7fff-cf01-fb75-a4aa0140c9e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u98df\u4e8b\u306e\u95a2\u4fc2\uff1a\u6804\u990a\u7d20\u306e\u4ee3\u8b1d\u3068\u9aa8\u306e\u5065\u5eb7<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001\u6804\u990a\u7d20\u306e\u5438\u53ce\u3084\u4ee3\u8b1d\u306e\u52b9\u7387\u304c\u5909\u308f\u308b\u305f\u3081\u3001\u500b\u4eba\u306b\u9069\u3057\u305f\u98df\u4e8b\u6226\u7565\u304c\u9aa8\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u4e0a\u3067\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. GC\u907a\u4f1d\u5b50\u3068\u30d3\u30bf\u30df\u30f3D\u306e\u4ee3\u8b1d<\/strong><\/h4>\n\n\n\n<p><strong>GC\uff08\u30d3\u30bf\u30df\u30f3D\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8840\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u8f38\u9001\u306b\u95a2\u4e0e\u3057\u3001\u305d\u306e\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002GC\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs4588\u304a\u3088\u3073rs7041\uff09\u304c\u3042\u308b\u3068\u3001\u8840\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u30ec\u30d9\u30eb\u304c\u4f4e\u304f\u306a\u308a\u3084\u3059\u304f\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/www.bmj.com\/content\/356\/bmj.i6583\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u6301\u3064\u4eba\u306f\u3001\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u901a\u3058\u3066\u7a4d\u6975\u7684\u306b\u30d3\u30bf\u30df\u30f3D\u3092\u88dc\u7d66\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. LRP5\u907a\u4f1d\u5b50\u3068\u30ab\u30eb\u30b7\u30a6\u30e0\u5438\u53ce<\/strong><\/h4>\n\n\n\n<p><strong>LRP5\uff08\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea5\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u9aa8\u5f62\u6210\u306b\u5fc5\u8981\u306a\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u53d6\u308a\u8fbc\u307f\u3092\u5236\u5fa1\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u9aa8\u306e\u5f37\u5ea6\u3084\u9aa8\u5bc6\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u7279\u306b\u5c0f\u5150\u671f\u306e\u9aa8\u767a\u80b2\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001LRP5\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u52b9\u7387\u304c\u4f4e\u304f\u3001\u6210\u9577\u671f\u306b\u304a\u3044\u3066\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u304f\u306a\u308b\u30ea\u30b9\u30af\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0309-5\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u7d50\u679c\u3092\u8e0f\u307e\u3048\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u6301\u3064\u4eba\u306b\u5bfe\u3057\u3066\u306f\u3001\u4e73\u88fd\u54c1\u3084\u30ab\u30eb\u30b7\u30a6\u30e0\u5f37\u5316\u98df\u54c1\u306e\u6442\u53d6\u304c\u52e7\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u3068\u9aa8\u306e\u5065\u5eb7\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u3001\u500b\u5225\u5316\u533b\u7642\u3084\u6804\u990a\u5b66\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u3055\u3089\u306b\u8a73\u7d30\u306a\u9aa8\u306e\u5065\u5eb7\u7ba1\u7406\u65b9\u6cd5\u304c\u78ba\u7acb\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9aa8\u6298\u30ea\u30b9\u30af\u3068\u907a\u4f1d\u7684\u8981\u56e0\uff1a\u907a\u4f1d\u5b50\u304c\u793a\u3059\u9aa8\u306e\u5f37\u5ea6\u3068\u56de\u5fa9\u529b<\/strong><\/h3>\n\n\n\n<p>\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u306f\u3001\u9aa8\u5bc6\u5ea6\u3060\u3051\u3067\u306a\u304f\u3001\u9aa8\u306e\u5fae\u7d30\u69cb\u9020\u3084\u56de\u5fa9\u529b\u306b\u3088\u3063\u3066\u3082\u6c7a\u307e\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7279\u6027\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u9aa8\u6298\u306e\u767a\u751f\u3084\u6cbb\u7652\u901f\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. SOST\u907a\u4f1d\u5b50\u3068\u9aa8\u5f62\u6210\u306e\u6291\u5236<\/strong><\/h4>\n\n\n\n<p><strong>SOST\uff08\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u9aa8\u306e\u5f62\u6210\u3092\u6291\u5236\u3059\u308b\u5f79\u5272\u3092\u6301\u3061\u3001\u7279\u306b\u9aa8\u5bc6\u5ea6\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u3067\u3059\u3002SOST\u304c\u904e\u5270\u306b\u767a\u73fe\u3059\u308b\u3068\u3001\u9aa8\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\uff08\u9aa8\u306e\u518d\u69cb\u7bc9\uff09\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u5bc6\u5ea6\u304c\u6e1b\u5c11\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u3067\u306f\u3001SOST\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs851054\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u5bc6\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-76023-1\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3001\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u306e\u5229\u7528\u304c\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-16354dda-7fff-cf01-fb75-a4aa0140c9e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. LRP4\u907a\u4f1d\u5b50\u3068\u9aa8\u6298\u306e\u56de\u5fa9\u529b<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4552752_m-1024x683.jpg\" alt=\"\n\u8db3\u3092\u602a\u6211\u3057\u305f\u7537\u6027\" class=\"wp-image-10370\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4552752_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4552752_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4552752_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4552752_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4552752_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>LRP4\uff08\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea4\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30b9\u30af\u30ec\u30ed\u30b9\u30c1\u30f3\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u9aa8\u306e\u5f62\u6210\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002LRP4\u306e\u5909\u7570\u306f\u3001\u9aa8\u6298\u5f8c\u306e\u56de\u5fa9\u901f\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001LRP4\u306e\u5909\u7570\uff08rs6485947\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u9aa8\u6298\u306e\u6cbb\u7652\u901f\u5ea6\u304c\u9045\u304f\u3001\u9aa8\u306e\u5fae\u7d30\u69cb\u9020\u304c\u5f31\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0223569\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u30ea\u30cf\u30d3\u30ea\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u958b\u767a\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9aa8\u306e\u5fae\u7d30\u69cb\u9020\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u9023\u6027<\/strong><\/h3>\n\n\n\n<p>\u9aa8\u5bc6\u5ea6\u306f\u9aa8\u306e\u5065\u5eb7\u3092\u8a55\u4fa1\u3059\u308b\u91cd\u8981\u306a\u6307\u6a19\u3067\u3059\u304c\u3001\u9aa8\u306e\u5f37\u5ea6\u306f\u5358\u306a\u308b\u5bc6\u5ea6\u3060\u3051\u3067\u306f\u6c7a\u307e\u308a\u307e\u305b\u3093\u3002\u9aa8\u306e\u5fae\u7d30\u69cb\u9020\u3001\u3059\u306a\u308f\u3061\u9aa8\u6881\uff08\u30c8\u30e9\u30d9\u30ad\u30e5\u30e9\u30fc\uff09\u3068\u76ae\u8cea\u9aa8\u306e\u539a\u307f\u304c\u3001\u9aa8\u306e\u8010\u4e45\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. CTSK\u907a\u4f1d\u5b50\u3068\u7834\u9aa8\u7d30\u80de\u306e\u6d3b\u6027\u5316<\/strong><\/h4>\n\n\n\n<p><strong>CTSK\uff08\u30ab\u30c6\u30d7\u30b7\u30f3K\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u7834\u9aa8\u7d30\u80de\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3001\u9aa8\u306e\u5438\u53ce\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002CTSK\u306e\u6d3b\u6027\u304c\u9ad8\u3059\u304e\u308b\u3068\u3001\u9aa8\u304c\u904e\u5270\u306b\u5206\u89e3\u3055\u308c\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u3067\u306f\u3001CTSK\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs12084041\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u7834\u9aa8\u7d30\u80de\u306e\u6d3b\u52d5\u304c\u6d3b\u767a\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u7279\u306b\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306b\u304a\u3044\u3066\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u304c\u9855\u8457\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.689456\/full\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u907a\u4f1d\u5b50\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u85ac\u5264\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. BMP2\u907a\u4f1d\u5b50\u3068\u9aa8\u306e\u518d\u751f\u80fd\u529b<\/strong><\/h4>\n\n\n\n<p><strong>BMP2\uff08\u9aa8\u5f62\u6210\u30bf\u30f3\u30d1\u30af\u8cea2\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u9aa8\u306e\u6210\u9577\u3084\u4fee\u5fa9\u306b\u5fc5\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u9aa8\u6298\u6cbb\u7642\u3084\u518d\u751f\u533b\u7642\u306e\u5206\u91ce\u3067\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002BMP2\u306e\u767a\u73fe\u304c\u4f4e\u3044\u3068\u3001\u9aa8\u306e\u5f62\u6210\u304c\u9045\u308c\u3001\u9aa8\u6298\u306e\u6cbb\u7652\u304c\u9577\u5f15\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001BMP2\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\uff08rs2273073\uff09\u304c\u9aa8\u6298\u306e\u6cbb\u7652\u901f\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41536-020-00103-y\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u9aa8\u306e\u4fee\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-16354dda-7fff-cf01-fb75-a4aa0140c9e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u52a0\u9f62\u3068\u9aa8\u306e\u5065\u5eb7\uff1a\u907a\u4f1d\u5b50\u306b\u3088\u308b\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<p>\u52a0\u9f62\u306b\u4f34\u3046\u9aa8\u306e\u5909\u5316\u306f\u3001\u5358\u306a\u308b\u751f\u6d3b\u7fd2\u6163\u306e\u5f71\u97ff\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u3082\u5de6\u53f3\u3055\u308c\u307e\u3059\u3002\u7279\u306b\u3001\u9aa8\u306e\u8001\u5316\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u5b50\u3084\u3001\u52a0\u9f62\u306b\u4f34\u3046\u9aa8\u5bc6\u5ea6\u306e\u6e1b\u5c11\u3092\u6291\u5236\u3059\u308b\u907a\u4f1d\u5b50\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. KL\u907a\u4f1d\u5b50\u3068\u9aa8\u306e\u8001\u5316\u6291\u5236<\/strong><\/h4>\n\n\n\n<p><strong>KL\uff08\u30af\u30ed\u30c8\u30fc\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u52a0\u9f62\u306b\u4f34\u3046\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u6291\u5236\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002KL\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u9aa8\u306e\u8001\u5316\u304c\u52a0\u901f\u3057\u3001\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001KL\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs9536314\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u4e00\u822c\u7684\u306a\u52a0\u9f62\u3088\u308a\u3082\u65e9\u304f\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u6298\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.jci.org\/articles\/view\/127572\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u77e5\u898b\u306f\u3001KL\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u7dad\u6301\u3059\u308b\u65b9\u6cd5\u3092\u63a2\u308b\u7814\u7a76\u306e\u91cd\u8981\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. FOXO3\u907a\u4f1d\u5b50\u3068\u6297\u9178\u5316\u4f5c\u7528<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/27545643_m-1024x574.jpg\" alt=\"\n\u85ac\u5264\u5e2b\u306e\u624b\u5143\u30a4\u30e1\u30fc\u30b803\" class=\"wp-image-10377\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27545643_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27545643_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27545643_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27545643_m-1536x861.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27545643_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>FOXO3\uff08Forkhead box O3\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3061\u3001\u7d30\u80de\u306e\u8001\u5316\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u9aa8\u306e\u8001\u5316\u304c\u65e9\u307e\u308a\u3001\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u3067\u306f\u3001FOXO3\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs2802292\uff09\u304c\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306b\u304a\u3044\u3066\u9aa8\u5bc6\u5ea6\u4f4e\u4e0b\u304c\u9855\u8457\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/academic.oup.com\/endo\/article\/161\/5\/bqaa049\/5813672\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u6297\u9178\u5316\u4f5c\u7528\u306e\u3042\u308b\u98df\u54c1\uff08\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3084\u30d3\u30bf\u30df\u30f3C\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u3001\u9aa8\u306e\u5065\u5eb7\u7dad\u6301\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-16354dda-7fff-cf01-fb75-a4aa0140c9e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u751f\u6d3b\u7fd2\u6163\u306e\u76f8\u4e92\u4f5c\u7528\uff1a\u9aa8\u306e\u5065\u5eb7\u3092\u6700\u9069\u5316\u3059\u308b\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u308b\u9aa8\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u306f\u3001\u74b0\u5883\u8981\u56e0\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u5de5\u592b\u306b\u3088\u3063\u3066\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u7279\u306b\u3001\u9069\u5207\u306a\u904b\u52d5\u3084\u6804\u990a\u6442\u53d6\u304c\u3001\u907a\u4f1d\u7684\u306a\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3092\u88dc\u3046\u624b\u6bb5\u3068\u3057\u3066\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>1. \u9069\u5ea6\u306a\u904b\u52d5<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9aa8\u306b\u9069\u5ea6\u306a\u8ca0\u8377\u3092\u304b\u3051\u308b\u3053\u3068\u3067\u3001\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u5b50\uff08BMP2\u3001RUNX2\uff09\u306e\u767a\u73fe\u3092\u5897\u3084\u3059\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>2. \u6804\u990a\u7ba1\u7406<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30ab\u30eb\u30b7\u30a6\u30e0\u3001\u30d3\u30bf\u30df\u30f3D\u3001\u30d3\u30bf\u30df\u30f3K2\u3001\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3001\u4e9c\u925b\u306e\u9069\u5207\u306a\u6442\u53d6\u304c\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>3. \u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7981\u7159\u3084\u904e\u5ea6\u306a\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u3092\u63a7\u3048\u308b\u3053\u3068\u3067\u3001\u9aa8\u306e\u52a3\u5316\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u7d50\u679c\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u7406\u89e3\u3057\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u9aa8\u306e\u5065\u5eb7\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642\u304c\u9032\u5c55\u3057\u3001\u500b\u3005\u306e\u9aa8\u306e\u7279\u6027\u306b\u5408\u308f\u305b\u305f\u6cbb\u7642\u3084\u4e88\u9632\u7b56\u304c\u958b\u767a\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9aa8\u306e\u5065\u5eb7\u3068\u907a\u4f1d\u7684\u591a\u69d8\u6027\uff1a\u6c11\u65cf\u3054\u3068\u306e\u907a\u4f1d\u7684\u9055\u3044<\/strong><\/h3>\n\n\n\n<p>\u9aa8\u5bc6\u5ea6\u3084\u9aa8\u6298\u30ea\u30b9\u30af\u306f\u3001\u500b\u4eba\u5dee\u3060\u3051\u3067\u306a\u304f\u3001\u6c11\u65cf\u3054\u3068\u306e\u907a\u4f1d\u7684\u9055\u3044\u306b\u3088\u3063\u3066\u3082\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u307e\u3056\u307e\u306a\u7814\u7a76\u306b\u3088\u308a\u3001\u7570\u306a\u308b\u6c11\u65cf\u96c6\u56e3\u306b\u304a\u3044\u3066\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u9aa8\u306e\u5065\u5eb7\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. WNT16\u907a\u4f1d\u5b50\u3068\u9aa8\u5bc6\u5ea6\u306e\u6c11\u65cf\u5dee<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/39699_m-1024x683.jpg\" alt=\"\" class=\"wp-image-9056\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39699_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39699_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39699_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39699_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39699_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>WNT16\uff08\u30a6\u30a3\u30f3\u30c816\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u9aa8\u5bc6\u5ea6\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u7279\u306b\u9aa8\u306e\u5fae\u7d30\u69cb\u9020\u3084\u76ae\u8cea\u9aa8\u306e\u5f37\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u6b27\u7c73\u4eba\u96c6\u56e3\u3067\u306fWNT16\u306eSNP\uff08rs3801387\uff09\u304c\u9aa8\u5bc6\u5ea6\u306e\u9ad8\u4f4e\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u4e00\u65b9\u3001\u30a2\u30b8\u30a2\u4eba\u96c6\u56e3\u3067\u306f\u3053\u306e\u907a\u4f1d\u7684\u591a\u578b\u306e\u5f71\u97ff\u304c\u5f31\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41588-018-0286-7\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u308c\u306f\u3001\u7570\u306a\u308b\u6c11\u65cf\u304c\u6301\u3064\u907a\u4f1d\u7684\u80cc\u666f\u306b\u3088\u3063\u3066\u3001\u9aa8\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u304c\u7570\u306a\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-16354dda-7fff-cf01-fb75-a4aa0140c9e4\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. LGR4\u907a\u4f1d\u5b50\u3068\u9aa8\u6298\u30ea\u30b9\u30af\u306e\u5730\u57df\u5dee<\/strong><\/h4>\n\n\n\n<p><strong>LGR4\uff08\u30ed\u30a4\u30b7\u30f3\u30ea\u30c3\u30c1G\u30d7\u30ed\u30c6\u30a4\u30f3\u5171\u5f79\u53d7\u5bb9\u4f534\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u9aa8\u82bd\u7d30\u80de\u306e\u5206\u5316\u3084\u9aa8\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\uff08rs6484295\uff09\u306f\u3001\u7279\u306b\u30e8\u30fc\u30ed\u30c3\u30d1\u4eba\u96c6\u56e3\u306b\u304a\u3044\u3066\u9aa8\u6298\u30ea\u30b9\u30af\u3068\u5f37\u3044\u76f8\u95a2\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001LGR4\u306e\u6a5f\u80fd\u4f4e\u4e0b\u578b\u5909\u7570\u3092\u6301\u3064\u30e8\u30fc\u30ed\u30c3\u30d1\u4eba\u306f\u3001\u9aa8\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u50be\u5411\u306b\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-021-82506-1\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3057\u304b\u3057\u3001\u65e5\u672c\u4eba\u3092\u542b\u3080\u6771\u30a2\u30b8\u30a2\u7cfb\u306e\u96c6\u56e3\u3067\u306f\u3053\u306e\u5909\u7570\u306e\u983b\u5ea6\u304c\u4f4e\u3044\u305f\u3081\u3001\u9aa8\u6298\u30ea\u30b9\u30af\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306f\u9650\u5b9a\u7684\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. ALDH7A1\u907a\u4f1d\u5b50\u3068\u9aa8\u4ee3\u8b1d\u306e\u9055\u3044<\/strong><\/h4>\n\n\n\n<p><strong>ALDH7A1\uff08\u30a2\u30eb\u30c7\u30d2\u30c9\u8131\u6c34\u7d20\u9175\u7d207A1\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30a2\u30df\u30ce\u9178\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3001\u9aa8\u306e\u5065\u5eb7\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001ALDH7A1\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u30d3\u30bf\u30df\u30f3B6\u306e\u4ee3\u8b1d\u3068\u95a2\u9023\u3057\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u30ea\u30b9\u30af\u3092\u5de6\u53f3\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u306e\u96c6\u56e3\u3067\u306fALDH7A1\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\uff08rs2276749\uff09\u304c\u9ad8\u983b\u5ea6\u3067\u898b\u3089\u308c\u3001\u9aa8\u5bc6\u5ea6\u306e\u7dad\u6301\u306b\u6709\u5229\u306b\u50cd\u3044\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2020.00879\/full\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u7684\u9055\u3044\u304c\u3001\u9aa8\u7c97\u9b06\u75c7\u306e\u767a\u75c7\u7387\u306e\u6c11\u65cf\u5dee\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9aa8\u306e\u5065\u5eb7\u3068\u30b9\u30c8\u30ec\u30b9\u306e\u95a2\u4fc2\uff1a\u907a\u4f1d\u5b50\u304c\u793a\u3059\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54<\/strong><\/h3>\n\n\n\n<p>\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u9aa8\u306e\u5065\u5eb7\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u304c\u904e\u5270\u306b\u5206\u6ccc\u3055\u308c\u308b\u3068\u3001\u9aa8\u5bc6\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5f71\u97ff\u306b\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. NR3C1\u907a\u4f1d\u5b50\u3068\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u611f\u53d7\u6027<\/strong><\/h4>\n\n\n\n<p><strong>NR3C1\uff08\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u4f5c\u7528\u3092\u8abf\u7bc0\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3078\u306e\u611f\u53d7\u6027\u304c\u7570\u306a\u308a\u3001\u305d\u308c\u304c\u9aa8\u306e\u5065\u5eb7\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u3067\u306f\u3001NR3C1\u306e\u7279\u5b9a\u306eSNP\uff08rs6198\uff09\u304c\u3042\u308b\u3068\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5206\u89e3\u304c\u9045\u308c\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u304c\u6301\u7d9a\u3057\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6343125\/\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u304c\u7279\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u9069\u5ea6\u306a\u904b\u52d5\u3084\u30ea\u30e9\u30af\u30bc\u30fc\u30b7\u30e7\u30f3\u304c\u9aa8\u306e\u5065\u5eb7\u7dad\u6301\u306b\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. HSD11B1\u907a\u4f1d\u5b50\u3068\u9aa8\u5438\u53ce\u306e\u4fc3\u9032<\/strong><\/h4>\n\n\n\n<p><strong>HSD11B1\uff08\u30d2\u30c9\u30ed\u30ad\u30b7\u30b9\u30c6\u30ed\u30a4\u30c9\u30c7\u30d2\u30c9\u30ed\u30b2\u30ca\u30fc\u30bc1\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u4f53\u5185\u306e\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u9aa8\u5438\u53ce\u4fc3\u9032\u4f5c\u7528\u304c\u5897\u5f37\u3055\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001HSD11B1\u306ers12086634\u3068\u3044\u3046SNP\u3092\u6301\u3064\u4eba\u306f\u3001\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u304c\u52a0\u901f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1505064\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u30ea\u30b9\u30af\u3092\u6301\u3064\u4eba\u306f\u3001\u9069\u5ea6\u306a\u30ab\u30eb\u30b7\u30a6\u30e0\u6442\u53d6\u3084\u6297\u30b9\u30c8\u30ec\u30b9\u5bfe\u7b56\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u9aa8\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u9aa8\u306e\u5065\u5eb7\u3068\u904b\u52d5\u80fd\u529b\uff1a\u907a\u4f1d\u5b50\u304c\u793a\u3059\u9aa8\u306e\u9069\u5fdc\u6027<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/2170021_m-1024x683.jpg\" alt=\"\u8a66\u5408\u3092\u3059\u308b\u30d0\u30ec\u30fc\u30dc\u30fc\u30eb\u9078\u624b\" class=\"wp-image-9606\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2170021_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2170021_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2170021_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2170021_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2170021_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9aa8\u306e\u5f37\u5ea6\u3084\u67d4\u8edf\u6027\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u9aa8\u306e\u9069\u5fdc\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u904b\u52d5\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u9aa8\u5bc6\u5ea6\u304c\u5909\u5316\u3059\u308b\u304b\u3069\u3046\u304b\u304c\u6c7a\u307e\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. VEGFA\u907a\u4f1d\u5b50\u3068\u9aa8\u8840\u6d41<\/strong><\/h4>\n\n\n\n<p><strong>VEGFA\uff08\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50A\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u8840\u7ba1\u306e\u6210\u9577\u3092\u4fc3\u9032\u3057\u3001\u9aa8\u3078\u306e\u8840\u6d41\u3092\u78ba\u4fdd\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002VEGFA\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u9aa8\u3078\u306e\u8840\u6d41\u304c\u4f4e\u4e0b\u3057\u3001\u904b\u52d5\u306b\u3088\u308b\u9aa8\u5bc6\u5ea6\u306e\u5411\u4e0a\u52b9\u679c\u304c\u5236\u9650\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001VEGFA\u306eSNP\uff08rs699947\uff09\u304c\u3042\u308b\u4eba\u306f\u3001\u904b\u52d5\u306b\u3088\u308b\u9aa8\u306e\u9069\u5fdc\u304c\u5f31\u304f\u3001\u9aa8\u6298\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/japplphysiol.00236.2019\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u907a\u4f1d\u7684\u80cc\u666f\u3092\u8003\u616e\u3057\u305f\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u91cd\u8981\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. ACAN\u907a\u4f1d\u5b50\u3068\u95a2\u7bc0\u306e\u9069\u5fdc\u6027<\/strong><\/h4>\n\n\n\n<p><strong>ACAN\uff08\u30a2\u30b0\u30ea\u30ab\u30f3\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u95a2\u7bc0\u8edf\u9aa8\u306e\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3001\u904b\u52d5\u6642\u306e\u885d\u6483\u5438\u53ce\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u8edf\u9aa8\u306e\u5f3e\u529b\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u9aa8\u3078\u306e\u8ca0\u62c5\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001ACAN\u306e\u5909\u7570\uff08rs1516797\uff09\u304c\u3042\u308b\u3068\u3001\u9577\u6642\u9593\u306e\u904b\u52d5\u306b\u3088\u308b\u95a2\u7bc0\u306e\u52a3\u5316\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-67845-2\">\u53c2\u8003\u8ad6\u6587<\/a>\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u306f\u9aa8\u306e\u5065\u5eb7\u306b\u591a\u9762\u7684\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u304a\u308a\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u4e88\u9632\u30fb\u7ba1\u7406\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u307e\u3068\u3081<\/p>\n\n\n\n<p>\u9aa8\u306e\u5065\u5eb7\u306f\u3001\u9aa8\u5bc6\u5ea6\u3001\u9aa8\u6298\u30ea\u30b9\u30af\u3001\u56de\u5fa9\u529b\u306a\u3069\u3001\u591a\u304f\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u3002<strong>WNT16<\/strong> \u3084 <strong>LGR4<\/strong> \u306f\u9aa8\u5bc6\u5ea6\u306b\u95a2\u4e0e\u3057\u3001<strong>NR3C1<\/strong> \u3084 <strong>HSD11B1<\/strong> \u306f\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u9aa8\u5438\u53ce\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u307e\u305f\u3001<strong>CYP2R1<\/strong> \u3084 <strong>ALPL<\/strong> \u306e\u5909\u7570\u306f\u30d3\u30bf\u30df\u30f3D\u3084\u30ea\u30f3\u306e\u4ee3\u8b1d\u306b\u5f71\u97ff\u3057\u3001\u9aa8\u306e\u30df\u30cd\u30e9\u30eb\u5316\u3092\u8abf\u6574\u3057\u307e\u3059\u3002\u6c11\u65cf\u306b\u3088\u308b\u907a\u4f1d\u7684\u9055\u3044\u3082\u9aa8\u6298\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3057\u3001\u9069\u5207\u306a\u6804\u990a\u6442\u53d6\u3084\u904b\u52d5\u304c\u91cd\u8981\u3067\u3059\u3002\u3055\u3089\u306b\u3001<strong>SP7<\/strong> \u3084 <strong>TGF-\u03b21<\/strong> \u306f\u9aa8\u5f62\u6210\u3084\u6cbb\u7652\u306b\u95a2\u4e0e\u3057\u3001\u9aa8\u6298\u5f8c\u306e\u56de\u5fa9\u901f\u5ea6\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u304c\u9032\u307f\u3001\u9aa8\u7c97\u9b06\u75c7\u3084\u9aa8\u6298\u306e\u4e88\u9632\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9aa8\u306e\u5065\u5eb7\u306f\u3001\u6211\u3005\u306e\u5168\u4f53\u7684\u306a\u5065\u5eb7\u72b6\u614b\u3084\u751f\u6d3b\u306e\u8cea\u306b\u76f4\u7d50\u3057\u3066\u3044\u307e\u3059\u3002\u9aa8\u7c97\u9b06\u75c7\u306a\u3069\u306e\u9aa8\u95a2\u9023\u75be\u60a3\u306f\u3001\u9ad8\u9f62\u5316\u793e\u4f1a\u306b\u304a\u3044\u3066\u307e\u3059\u307e\u3059\u91cd\u8981\u306a\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u306f\u3001\u74b0\u5883\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3082\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044 [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":10363,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10362","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=10362"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10362\/revisions"}],"predecessor-version":[{"id":10384,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10362\/revisions\/10384"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/10363"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=10362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=10362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=10362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}