{"id":10436,"date":"2025-03-19T03:48:07","date_gmt":"2025-03-19T03:48:07","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10436"},"modified":"2025-03-19T03:48:08","modified_gmt":"2025-03-19T03:48:08","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%a5%9e%e7%b5%8c%e7%b3%bb%e7%96%be%e6%82%a3%ef%bc%9a%e4%ba%88%e9%98%b2%e3%81%a8%e6%b2%bb%e7%99%82%e3%81%ae%e6%96%b0%e3%81%97%e3%81%84%e3%82%a2%e3%83%97%e3%83%ad","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%a5%9e%e7%b5%8c%e7%b3%bb%e7%96%be%e6%82%a3%ef%bc%9a%e4%ba%88%e9%98%b2%e3%81%a8%e6%b2%bb%e7%99%82%e3%81%ae%e6%96%b0%e3%81%97%e3%81%84%e3%82%a2%e3%83%97%e3%83%ad\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u795e\u7d4c\u7cfb\u75be\u60a3\uff1a\u4e88\u9632\u3068\u6cbb\u7642\u306e\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1"},"content":{"rendered":"\n<p>\u795e\u7d4c\u7cfb\u75be\u60a3\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3001\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u306a\u3069\u3001\u591a\u5c90\u306b\u308f\u305f\u308b\u75c7\u72b6\u3068\u9032\u884c\u30d1\u30bf\u30fc\u30f3\u3092\u6301\u3064\u75be\u60a3\u7fa4\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u591a\u304f\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u7406\u89e3\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u65b0\u3057\u3044\u4e88\u9632\u6cd5\u3084\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 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class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 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class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30b1\u30df\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u3092\u7528\u3044\u305f\u6cbb\u7642\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u795e\u7d4c\u907a\u4f1d\u75c5\u306e\u4e2d\u306b\u306f\u3001\u9175\u7d20\u306e\u6a5f\u80fd\u4e0d\u5168\u304c\u539f\u56e0\u3067\u767a\u75c7\u3059\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u75be\u60a3\u306b\u5bfe\u3057\u3066\u3001\u57fa\u8cea\u3084\u53cd\u5fdc\u7523\u7269\u306b\u985e\u4f3c\u3057\u305f\u69cb\u9020\u3092\u6301\u3064\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3092\u30b1\u30df\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u4f7f\u7528\u3057\u3001\u5909\u7570\u3057\u305f\u9175\u7d20\u306e\u7d30\u80de\u5185\u5b89\u5b9a\u6027\u3092\u9ad8\u3081\u3001\u6d3b\u6027\u3092\u56de\u5fa9\u3055\u305b\u308b\u8a66\u307f\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u03b2-\u30ac\u30e9\u30af\u30c8\u30b7\u30c9\u30fc\u30b7\u30b9\u3084\u30d5\u30a1\u30d6\u30ea\u30fc\u75c5\u306a\u3069\u306e\u30e9\u30a4\u30bd\u30be\u30fc\u30e0\u75c5\u306b\u304a\u3044\u3066\u3001\u30b1\u30df\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u306e\u9069\u7528\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u5f93\u6765\u306e\u9175\u7d20\u88dc\u5145\u7642\u6cd5\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u3068\u306f\u7570\u306a\u308b\u8996\u70b9\u304b\u3089\u3001\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30c8\u30ec\u30cf\u30ed\u30fc\u30b9\u306b\u3088\u308b\u795e\u7d4c\u5909\u6027\u4e88\u9632<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/27263496_m-1024x683.jpg\" alt=\"\n\u8eca\u6905\u5b50\u306b\u4e57\u308b\u9ad8\u9f62\u8005\u7537\u6027\u3068\u5973\u6027\u306e\u4ecb\u8b77\u58eb\" class=\"wp-image-10449\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27263496_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27263496_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27263496_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27263496_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27263496_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 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\/><\/figure>\n\n\n\n<p>\u30c8\u30ec\u30cf\u30ed\u30fc\u30b9\u306f\u3001\u81ea\u7136\u754c\u306b\u5b58\u5728\u3059\u308b\u4e8c\u7cd6\u985e\u3067\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u3092\u6291\u5236\u3057\u3001\u795e\u7d4c\u5909\u6027\u3092\u4e88\u9632\u3059\u308b\u52b9\u679c\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7406\u5316\u5b66\u7814\u7a76\u6240\u306e\u7814\u7a76\u3067\u306f\u3001\u30c8\u30ec\u30cf\u30ed\u30fc\u30b9\u304c\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3001\u30dd\u30ea\u30b0\u30eb\u30bf\u30df\u30f3\u5a92\u4ecb\u6027\u306e\u75c5\u7406\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u5206\u5b50\u5b89\u5b9a\u5316\u306b\u3088\u308b\u795e\u7d4c\u5909\u6027\u4e88\u9632\u306e\u53ef\u80fd\u6027\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\u3001\u4ed6\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3078\u306e\u5fdc\u7528\u3082\u671f\u5f85\u3055\u308c\u3066\u304a\u308a\u3001\u65b0\u3057\u3044\u6cbb\u7642\u6226\u7565\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>RNA\u5e72\u6e09\uff08RNAi\uff09\u306b\u3088\u308b\u907a\u4f1d\u5b50\u6cbb\u7642<\/strong><\/h2>\n\n\n\n<p>RNA\u5e72\u6e09\uff08RNAi\uff09\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u6280\u8853\u3067\u3042\u308a\u3001\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u5909\u7570\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u751f\u6210\u3055\u308c\u308b\u75be\u60a3\u306b\u5bfe\u3057\u3066\u6709\u52b9\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u3067\u306f\u3001HTT\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u7570\u5e38\u306a\u30cf\u30f3\u30c1\u30f3\u30c1\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u4e0d\u5168\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002RNAi\u6280\u8853\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001HTT\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306a\u767a\u73fe\u3092\u6291\u5236\u3057\u3001\u795e\u7d4c\u5909\u6027\u3092\u8efd\u6e1b\u3059\u308b\u8a66\u307f\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001ALS\uff08\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff09\u3067\u306f\u3001SOD1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u5909\u7570\u304c\u75c5\u614b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002RNAi\u6280\u8853\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001SOD1\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u4fdd\u8b77\u3092\u56f3\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001RNAi\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u6cbb\u7642\u85ac\u304cALS\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u306b\u9032\u3093\u3067\u304a\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u6cbb\u7642\u306e\u9078\u629e\u80a2\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30de\u30a4\u30af\u30edRNA\uff08miRNA\uff09\u3068\u795e\u7d4c\u7cfb\u75be\u60a3<\/strong><\/h2>\n\n\n\n<p>\u30de\u30a4\u30af\u30edRNA\uff08miRNA\uff09\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5fae\u8abf\u6574\u3059\u308b\u5c0f\u3055\u306aRNA\u5206\u5b50\u3067\u3042\u308a\u3001\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306emiRNA\u304c\u795e\u7d4c\u7d30\u80de\u306e\u751f\u5b58\u3084\u30b7\u30ca\u30d7\u30b9\u53ef\u5851\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u3001miR-29\u3084miR-146\u304c\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u84c4\u7a4d\u3084\u795e\u7d4c\u708e\u75c7\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306emiRNA\u306e\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u3001\u75c5\u614b\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u306f\u3001miR-133b\u304c\u30c9\u30fc\u30d1\u30df\u30f3\u795e\u7d4c\u7d30\u80de\u306e\u751f\u5b58\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002miR-133b\u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u795e\u7d4c\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u904b\u52d5\u969c\u5bb3\u304c\u9032\u884c\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001miR-133b\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u795e\u7d4c\u5909\u6027\u75be\u60a3<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1024x683.jpg\" alt=\"\uff24\uff2e\uff21\uff14\uff15\" class=\"wp-image-8664\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39742_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u306f\u3001DNA\u306e\u5869\u57fa\u914d\u5217\u3092\u5909\u3048\u305a\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u3053\u3068\u3092\u6307\u3057\u307e\u3059\u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u591a\u304f\u3067\u306f\u3001DNA\u30e1\u30c1\u30eb\u5316\u3084\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u306e\u7570\u5e38\u304c\u75c5\u614b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u3067\u306f\u3001\u7279\u5b9a\u306e\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u30d1\u30bf\u30fc\u30f3\u304c\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30d2\u30b9\u30c8\u30f3\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\uff08HDAC\uff09\u963b\u5bb3\u5264\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u7570\u5e38\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6b63\u5e38\u5316\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308b\u8a66\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u3001DNA\u30e1\u30c1\u30eb\u5316\u306e\u5909\u5316\u304c\u8133\u5185\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u84c4\u7a4d\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002DNA\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08DNMT\uff09\u963b\u5bb3\u5264\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u7570\u5e38\u306aDNA\u30e1\u30c1\u30eb\u5316\u3092\u4fee\u6b63\u3057\u3001\u75c5\u614b\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u518d\u751f\u533b\u7642<\/strong><\/h2>\n\n\n\n<p>\u795e\u7d4c\u5e79\u7d30\u80de\uff08NSC\uff09\u306f\u3001\u65b0\u3057\u3044\u795e\u7d4c\u7d30\u80de\u3092\u751f\u307f\u51fa\u3059\u80fd\u529b\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u810a\u9ac4\u640d\u50b7\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u518d\u751f\u533b\u7642\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u7523\u751f\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6e1b\u5c11\u304c\u4e3b\u306a\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u304c\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u79fb\u690d\u3059\u308b\u3053\u3068\u3067\u3001\u65b0\u3057\u3044\u30c9\u30fc\u30d1\u30df\u30f3\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u88dc\u5145\u3057\u3001\u75c7\u72b6\u306e\u6539\u5584\u3092\u56f3\u308b\u8a66\u307f\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001iPS\u7d30\u80de\u7531\u6765\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u79fb\u690d\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u304c\u958b\u59cb\u3055\u308c\u3066\u304a\u308a\u3001\u5c06\u6765\u7684\u306a\u5b9f\u7528\u5316\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>ALS\u3067\u306f\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u810a\u9ac4\u306b\u79fb\u690d\u3059\u308b\u3053\u3068\u3067\u3001\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u751f\u5b58\u3092\u52a9\u3051\u3001\u75be\u60a3\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u8a66\u307f\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u5e79\u7d30\u80de\u304c\u653e\u51fa\u3059\u308b\u795e\u7d4c\u6804\u990a\u56e0\u5b50\u304c\u795e\u7d4c\u7d30\u80de\u306e\u4fdd\u8b77\u306b\u5f79\u7acb\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u7814\u7a76\u306e\u9032\u5c55\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u795e\u7d4c\u75be\u60a3\u306e\u4e88\u9632<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u30ef\u30af\u30c1\u30f3\u306f\u3001\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3057\u3066\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u3001\u75be\u60a3\u306e\u767a\u75c7\u3092\u9632\u3050\u6280\u8853\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u611f\u67d3\u75c7\u306e\u4e88\u9632\u306b\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u6cbb\u7642\u3084\u4e88\u9632\u306b\u3082\u5fdc\u7528\u3055\u308c\u59cb\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u3067\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3092\u6a19\u7684\u3068\u3057\u305f\u30ef\u30af\u30c1\u30f3\u304c\u8a66\u9a13\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u7cfb\u304c\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3092\u6392\u9664\u3057\u3001\u75c5\u614b\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-7d4724ce-7fff-b07d-c68d-f31b5f041b0a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u7814\u7a76\u30ea\u30f3\u30af<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>RNA\u5e72\u6e09\u306b\u3088\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6cbb\u7642<\/strong><strong><br><\/strong><a href=\"https:\/\/www.nature.com\/articles\/nrd.2016.85\"> RNA interference therapies for neurodegenerative diseases<br><\/a><\/li>\n\n\n\n<li><strong>\u30de\u30a4\u30af\u30edRNA\u3068\u795e\u7d4c\u75be\u60a3<\/strong><strong><br><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4310531\/\"> MicroRNAs in neurodegenerative diseases<br><\/a><\/li>\n\n\n\n<li><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5<\/strong><strong><br><\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41574-019-0174-x\"> Epigenetic mechanisms in Alzheimer&#8217;s disease<br><\/a><\/li>\n\n\n\n<li><strong>\u795e\u7d4c\u5e79\u7d30\u80de\u79fb\u690d\u306b\u3088\u308b\u6cbb\u7642<\/strong><strong><br><\/strong><a href=\"https:\/\/stemcellsjournals.onlinelibrary.wiley.com\/doi\/full\/10.1002\/stem.227\"> Neural stem cells in regenerative medicine<br><\/a><\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u6cbb\u7642<\/strong><strong><br><\/strong><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.01893\/full\"> Alzheimer&#8217;s disease vaccines: Current status and future directions<br><\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u5408\u6210\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg\" alt=\"\" class=\"wp-image-9460\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31748166_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u5408\u6210\u3084\u5206\u89e3\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>\u30c1\u30ed\u30b7\u30f3\u6c34\u9178\u5316\u9175\u7d20\uff08TH\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3057\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5408\u6210\u306b\u95a2\u308f\u308b<strong>TPH2\uff08\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u6c34\u9178\u5316\u9175\u7d202\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u3001\u3046\u3064\u75c5\u3084\u4e0d\u5b89\u969c\u5bb3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002TPH2\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u30ec\u30d9\u30eb\u304c\u4f4e\u304f\u306a\u308a\u3084\u3059\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001<strong>COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u30c9\u30fc\u30d1\u30df\u30f3\u3084\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306e\u5206\u89e3\u3092\u8abf\u7bc0\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3088\u3063\u3066\u601d\u8003\u306e\u67d4\u8edf\u6027\u3084\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001COMT\u306e\u300c\u4f4e\u6d3b\u6027\u578b\u300d\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u304c\u9577\u304f\u8133\u5185\u306b\u7559\u307e\u308a\u3084\u3059\u304f\u3001\u8a18\u61b6\u529b\u304c\u9ad8\u3044\u4e00\u65b9\u3067\u30b9\u30c8\u30ec\u30b9\u306b\u5f31\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30cb\u30e5\u30fc\u30ed\u30d7\u30e9\u30b9\u30c6\u30a3\u30b7\u30c6\u30a3<\/strong><\/h2>\n\n\n\n<p>\u30cb\u30e5\u30fc\u30ed\u30d7\u30e9\u30b9\u30c6\u30a3\u30b7\u30c6\u30a3\uff08\u795e\u7d4c\u53ef\u5851\u6027\uff09\u306f\u3001\u8133\u304c\u74b0\u5883\u3084\u7d4c\u9a13\u306b\u5fdc\u3058\u3066\u5909\u5316\u3059\u308b\u80fd\u529b\u3092\u6307\u3057\u3001\u5b66\u7fd2\u3084\u8a18\u61b6\u3001\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001<strong>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u907a\u4f1d\u5b50<\/strong> \u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>BDNF\u306f\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3084\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u8133\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u306b\u3001BDNF\u306e\u300cVal66Met\u300d\u591a\u578b\u306f\u3001\u8a18\u61b6\u529b\u3084\u8a8d\u77e5\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u3082\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>BDNF\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u3001\u904b\u52d5\u3084\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3001\u7279\u5b9a\u306e\u6804\u990a\u7d20\uff08\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3084\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u795e\u7d4c\u53ef\u5851\u6027\u3092\u5f37\u5316\u3057\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u4e88\u9632\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u7761\u7720\u969c\u5bb3<\/strong><\/h2>\n\n\n\n<p>\u7761\u7720\u306e\u8cea\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u90e8\u5206\u304c\u5927\u304d\u304f\u3001\u7279\u306b<strong>PER\uff08Period\uff09\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>CLOCK\u907a\u4f1d\u5b50<\/strong> \u304c\u6982\u65e5\u30ea\u30ba\u30e0\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001PER3\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u3001\u671d\u578b\u30fb\u591c\u578b\u306e\u50be\u5411\u3092\u6c7a\u5b9a\u3057\u3001\u4e00\u90e8\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u6162\u6027\u7684\u306a\u7761\u7720\u4e0d\u8db3\u306b\u9665\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\uff08\u7a81\u7136\u306e\u7720\u6c17\u3084\u8131\u529b\u767a\u4f5c\u3092\u5f15\u304d\u8d77\u3053\u3059\u75be\u60a3\uff09\u306f\u3001HLA-DQB1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u306f\u3001\u514d\u75ab\u7cfb\u306e\u7570\u5e38\u306b\u3088\u308a\u3001\u7761\u7720\u899a\u9192\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308b\u795e\u7d4c\u30da\u30d7\u30c1\u30c9\u300c\u30aa\u30ec\u30ad\u30b7\u30f3\u300d\u304c\u6e1b\u5c11\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u7684\u8981\u56e0\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u7761\u7720\u969c\u5bb3\u306e\u8a3a\u65ad\u3084\u6cbb\u7642\u3092\u3088\u308a\u500b\u5225\u5316\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u5149\u7642\u6cd5\u3084\u30e1\u30e9\u30c8\u30cb\u30f3\u88dc\u5145\u7642\u6cd5\u306e\u9069\u7528\u304c\u3088\u308a\u7cbe\u5bc6\u306b\u884c\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1024x585.jpg\" alt=\"\" class=\"wp-image-9488\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31075536_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u751f\u7523\u3092\u62c5\u3046\u91cd\u8981\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u3067\u3042\u308a\u3001\u305d\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\u7279\u306b\u3001<strong>MT-ND1\u3001MT-ND4\u3001MT-CO1<\/strong> \u306a\u3069\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff08mtDNA\uff09\u306e\u5909\u7570\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u306f\u3001PINK1\u3084PRKN\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u8cea\u306e\u7dad\u6301\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u4e0d\u826f\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u84c4\u7a4d\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d50\u679c\u3001\u795e\u7d4c\u7d30\u80de\u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u306b\u9665\u308a\u3001\u5f90\u3005\u306b\u6a5f\u80fd\u3092\u5931\u3063\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u3084\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306a\u3069\u306e\u88dc\u52a9\u56e0\u5b50\u306e\u6442\u53d6\u304c\u6709\u52b9\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u904b\u52d5\u3084\u65ad\u98df\uff08\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u4fc3\u9032\uff09\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30ea\u30b5\u30a4\u30af\u30eb\u304c\u4fc3\u9032\u3055\u308c\u3001\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u4e88\u9632\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u514d\u75ab\u7cfb\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u767a\u75c7\u306b\u306f\u514d\u75ab\u7cfb\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7279\u306b\u3001<strong>HLA\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>TREM2\u907a\u4f1d\u5b50<\/strong> \u304c\u514d\u75ab\u5fdc\u7b54\u3068\u795e\u7d4c\u5909\u6027\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>TREM2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\uff08\u8133\u306e\u514d\u75ab\u7d30\u80de\uff09\u306e\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u9664\u53bb\u80fd\u529b\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u9032\u884c\u304c\u52a0\u901f\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u95a2\u9023\u306e\u3042\u308bHLA\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u795e\u7d4c\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u514d\u75ab\u8abf\u6574\u7642\u6cd5\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u7814\u7a76\u30ea\u30f3\u30af<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/strong><strong><br><\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41380-020-00915-0\"> Genetics of neurotransmitter systems and neuropsychiatric disorders<br><\/a><\/li>\n\n\n\n<li><strong>BDNF\u3068\u795e\u7d4c\u53ef\u5851\u6027<\/strong><strong><br><\/strong><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2020.00257\/full\"> BDNF and synaptic plasticity<br><\/a><\/li>\n\n\n\n<li><strong>\u7761\u7720\u907a\u4f1d\u5b50\u3068\u6982\u65e5\u30ea\u30ba\u30e0<\/strong><strong><br><\/strong><a href=\"https:\/\/academic.oup.com\/sleep\/article\/35\/1\/25\/2709438\"> Circadian genes and sleep disorders<br><\/a><\/li>\n\n\n\n<li><strong>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3068\u795e\u7d4c\u75be\u60a3<\/strong><strong><br><\/strong><a href=\"https:\/\/www.nature.com\/articles\/nrn3474\"> Mitochondrial dysfunction in neurodegeneration<br><\/a><\/li>\n\n\n\n<li><strong>\u514d\u75ab\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5<\/strong><strong><br><\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-0873-9\"> Genetic risk factors for Alzheimer&#8217;s disease<br><\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08\u81ea\u98df\u4f5c\u7528\uff09\u306f\u3001\u7d30\u80de\u304c\u81ea\u8eab\u306e\u4e0d\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u640d\u50b7\u3057\u305f\u5c0f\u5668\u5b98\u3092\u5206\u89e3\u30fb\u30ea\u30b5\u30a4\u30af\u30eb\u3059\u308b\u4ed5\u7d44\u307f\u3067\u3042\u308a\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u4e88\u9632\u3084\u6cbb\u7642\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6d3b\u6027\u306f <strong>ATG\uff08Autophagy-related\uff09\u907a\u4f1d\u5b50\u7fa4<\/strong> \u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u6a5f\u80fd\u7570\u5e38\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>ATG5<\/strong> \u3084 <strong>ATG7<\/strong> \u306e\u5909\u7570\u306b\u3088\u308a\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u3084\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u84c4\u7a4d\u304c\u9032\u307f\u3001\u795e\u7d4c\u7d30\u80de\u304c\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u9006\u306b\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u3057\u3001\u795e\u7d4c\u5909\u6027\u3092\u6291\u3048\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u4fc3\u9032\u3059\u308b\u5316\u5408\u7269\u3068\u3057\u3066\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u3084\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u304c\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u5316\u5408\u7269\u304c\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u30e2\u30c7\u30eb\u52d5\u7269\u306e\u795e\u7d4c\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u65ad\u98df\u3084\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3082\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u6d3b\u6027\u5316\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u5065\u5eb7\u7dad\u6301\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/30819196_m-1-1024x683.jpg\" alt=\"\u773c\u7cbe\u75b2\u52b4\u30fb\u30c9\u30e9\u30a4\u30a2\u30a4\u304c\u8f9b\u3044\u30d3\u30b8\u30cd\u30b9\u30de\u30f3\" class=\"wp-image-6834\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30819196_m-1-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30819196_m-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30819196_m-1-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30819196_m-1-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30819196_m-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306f\u795e\u7d4c\u7cfb\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u3046\u3064\u75c5\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u306f <strong>FKBP5<\/strong> \u3084 <strong>NR3C1\uff08\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff09\u907a\u4f1d\u5b50<\/strong> \u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\u304c\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001<strong>FKBP5\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8<\/strong> \u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306e\u4f5c\u7528\u304c\u904e\u5270\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u308b\u3068\u8133\u306e\u795e\u7d4c\u7d30\u80de\u304c\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3084\u904b\u52d5\u3001\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u306a\u3069\u306e\u4ecb\u5165\u304c\u7279\u306b\u91cd\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001NR3C1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u904e\u5270\u6d3b\u6027\u5316\u3084\u30b9\u30c8\u30ec\u30b9\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u9577\u671f\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u304c\u6d77\u99ac\u306e\u795e\u7d4c\u53ef\u5851\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u8a18\u61b6\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u795e\u7d4c\u708e\u75c7<\/strong><\/h2>\n\n\n\n<p>\u795e\u7d4c\u708e\u75c7\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3092\u542b\u3080\u591a\u304f\u306e\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u75c5\u614b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b <strong>NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0<\/strong> \u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u3001\u795e\u7d4c\u7d30\u80de\u304c\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-1\u03b2\u3084IL-18\uff09\u3092\u904e\u5270\u306b\u653e\u51fa\u3057\u3001\u795e\u7d4c\u640d\u50b7\u3092\u52a0\u901f\u3055\u305b\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>NLRP3\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u795e\u7d4c\u708e\u75c7\u306e\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u6162\u6027\u7684\u306a\u708e\u75c7\u72b6\u614b\u304c\u6301\u7d9a\u3057\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001NLRP3\u306e\u6d3b\u6027\u3092\u6291\u5236\u3059\u308b\u5316\u5408\u7269\uff08\u30ab\u30d5\u30a7\u30a4\u30f3\u3001\u30af\u30eb\u30af\u30df\u30f3\u306a\u3069\uff09\u304c\u708e\u75c7\u6291\u5236\u4f5c\u7528\u3092\u6301\u3061\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u4e88\u9632\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>TREM2\uff08Triggering Receptor Expressed on Myeloid Cells 2\uff09\u907a\u4f1d\u5b50<\/strong> \u306e\u5909\u7570\u306f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6d3b\u6027\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u7570\u5e38\u306a\u6d3b\u6027\u5316\u306f\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u84c4\u7a4d\u3092\u4fc3\u9032\u3057\u3001\u795e\u7d4c\u708e\u75c7\u3092\u60aa\u5316\u3055\u305b\u308b\u305f\u3081\u3001TREM2\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u304c\u73fe\u5728\u958b\u767a\u4e2d\u3067\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u8840\u6db2\u8133\u95a2\u9580\u306e\u6a5f\u80fd<\/strong><\/h2>\n\n\n\n<p>\u8840\u6db2\u8133\u95a2\u9580\uff08BBB\uff09\u306f\u3001\u8133\u3092\u4fdd\u8b77\u3059\u308b\u30d0\u30ea\u30a2\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u6709\u5bb3\u7269\u8cea\u306e\u4fb5\u5165\u3092\u9632\u3050\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001<strong>ABCB1\uff08P-\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u907a\u4f1d\u5b50<\/strong> \u3084 <strong>TJP1\uff08\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u907a\u4f1d\u5b50<\/strong> \u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u3053\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u708e\u75c7\u6027\u56e0\u5b50\u3084\u6709\u5bb3\u7269\u8cea\u304c\u8133\u5185\u306b\u4fb5\u5165\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001ABCB1\u907a\u4f1d\u5b50\u306e\u4f4e\u6d3b\u6027\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u8840\u6db2\u8133\u95a2\u9580\u306e\u6a5f\u80fd\u3092\u5f37\u5316\u3059\u308b\u6804\u990a\u7d20\uff08DHA\u3084\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff09\u3084\u3001\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\uff08\u6297\u9178\u5316\u98df\u54c1\u306e\u6442\u53d6\u3001\u9069\u5ea6\u306a\u904b\u52d5\uff09\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u8178\u5185\u7d30\u83cc\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/27334792_m-1024x574.jpg\" alt=\"\n\u305f\u3063\u3077\u308a\u306e\u30d5\u30eb\u30fc\u30c4\u3068\u30e8\u30fc\u30b0\u30eb\u30c8\" class=\"wp-image-10456\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27334792_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27334792_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27334792_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27334792_m-1536x861.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/27334792_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\u3068\u795e\u7d4c\u7cfb\u306e\u95a2\u4fc2\u306f\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u300c\u8178-\u8133\u76f8\u95a2\u300d\u3068\u3057\u3066\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>FUT2\uff08\u30d5\u30b3\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc2\uff09\u907a\u4f1d\u5b50<\/strong> \u306f\u8178\u5185\u7d30\u83cc\u306e\u69cb\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>FUT2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u8178\u5185\u306e\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u306e\u91cf\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3001\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09\u306e\u7523\u751f\u304c\u4f4e\u4e0b\u3057\u3001\u795e\u7d4c\u708e\u75c7\u304c\u4fc3\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u9032\u884c\u304c\u52a0\u901f\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>LPS\uff08\u30ea\u30dd\u30dd\u30ea\u30b5\u30c3\u30ab\u30e9\u30a4\u30c9\uff09<\/strong> \u3068\u3044\u3046\u8178\u5185\u7d30\u83cc\u7531\u6765\u306e\u708e\u75c7\u56e0\u5b50\u304c\u8840\u6db2\u8133\u95a2\u9580\u3092\u901a\u904e\u3057\u3001\u8133\u5185\u3067\u795e\u7d4c\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u98df\u7269\u7e4a\u7dad\uff09\u3084\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u4e73\u9178\u83cc\u30fb\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u8178\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u7814\u7a76\u30ea\u30f3\u30af<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3068\u795e\u7d4c\u5909\u6027\u75be\u60a3<\/strong><strong><br><\/strong><a href=\"https:\/\/www.nature.com\/articles\/nrn3668\"> Autophagy and neurodegenerative diseases<br><\/a><\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u3068\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u95a2\u4fc2<\/strong><strong><br><\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41380-020-00912-3\"> Stress, genetics, and neuropsychiatric disorders<br><\/a><\/li>\n\n\n\n<li><strong>\u795e\u7d4c\u708e\u75c7\u3068TREM2\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7127387\/\"> TREM2 and neuroinflammation in Alzheimer&#8217;s disease<br><\/a><\/li>\n\n\n\n<li><strong>\u8178\u5185\u7d30\u83cc\u3068\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u95a2\u4fc2<\/strong><strong><br><\/strong><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2020.00023\/full\"> Gut microbiota and neurodegenerative disorders<br><\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u795e\u7d4c\u7cfb\u75be\u60a3\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u304c\u98db\u8e8d\u7684\u306b\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002AI\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u89e3\u6790\u3084\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\uff08CRISPR-Cas9\u3001\u30d9\u30fc\u30b9\u30a8\u30c7\u30a3\u30c6\u30a3\u30f3\u30b0\u306a\u3069\uff09\u3001iPS\u7d30\u80de\u3092\u7528\u3044\u305f\u518d\u751f\u533b\u7642\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6280\u8853\u306f\u3001\u75be\u60a3\u306e\u65e9\u671f\u8a3a\u65ad\u3084\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u3092\u53ef\u80fd\u306b\u3057\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u5b89\u5168\u6027\u3084\u502b\u7406\u7684\u8ab2\u984c\u3001\u30b3\u30b9\u30c8\u306e\u554f\u984c\u306a\u3069\u3001\u89e3\u6c7a\u3059\u3079\u304d\u8ab2\u984c\u3082\u591a\u304f\u3001\u614e\u91cd\u306a\u7814\u7a76\u3068\u9069\u5207\u306a\u30eb\u30fc\u30eb\u4f5c\u308a\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> 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[&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":10442,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10436","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10436","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=10436"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10436\/revisions"}],"predecessor-version":[{"id":10463,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/10436\/revisions\/10463"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/10442"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=10436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=10436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=10436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}