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class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u95a2\u9023\u75be\u60a3\u306e\u767a\u75c7\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30b9\u30c8\u30ec\u30b9\u30d5\u30eb\u306a\u30e9\u30a4\u30d5\u30a4\u30d9\u30f3\u30c8\u3068\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u3001\u3046\u3064\u72b6\u614b\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u65b0\u305f\u306b\u540c\u5b9a\u3055\u308c\u305fBMP2\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30d5\u30eb\u306a\u51fa\u6765\u4e8b\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u3046\u3064\u72b6\u614b\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u89aa\u5b50\u95a2\u4fc2\u3068\u907a\u4f1d\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u3001\u5b50\u4f9b\u306e\u8133\u306e\u767a\u9054\u3084\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6bcd\u89aa\u306e\u53d7\u5bb9\u6027\u3068FKBP5\u907a\u4f1d\u5b50\u306e\u591a\u578b\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u3001\u5b50\u4f9b\u306e\u8996\u5e8a\u3084\u5927\u8133\u57fa\u5e95\u6838\u306e\u7070\u767d\u8cea\u4f53\u7a4d\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30b9\u30c8\u30ec\u30b9\u3068\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/32045302_m-1024x683.jpg\" alt=\"\n\u8003\u3048\u3054\u3068\u3092\u3059\u308b\u30a8\u30d7\u30ed\u30f3\u59ff\u306e\u5973\u6027\" class=\"wp-image-10472\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32045302_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32045302_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32045302_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32045302_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32045302_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u304c\u79c1\u305f\u3061\u306e\u4f53\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306f\u3001\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u306f\u3001\u795e\u7d4c\u7d30\u80de\u9593\u3067\u60c5\u5831\u3092\u4f1d\u9054\u3059\u308b\u5316\u5b66\u7269\u8cea\u3067\u3042\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u3092\u8abf\u7bc0\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u7279\u306b\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u3001\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306e4\u3064\u304c\u30b9\u30c8\u30ec\u30b9\u3068\u95a2\u9023\u304c\u6df1\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-caf10467-7fff-e83d-62cd-a4c10ad390bd\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h3>\n\n\n\n<p>\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306f\u3001\u526f\u814e\u76ae\u8cea\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308a\u3001\u4f53\u304c\u30b9\u30c8\u30ec\u30b9\u306b\u9069\u5fdc\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u308b\u3068\u3001\u8133\u306e\u8996\u5e8a\u4e0b\u90e8\u2014\u4e0b\u5782\u4f53\u2014\u526f\u814e\u7cfb\uff08HPA\u8ef8\uff09\u304c\u6d3b\u6027\u5316\u3057\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5206\u6ccc\u304c\u4fc3\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u308a\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5206\u6ccc\u91cf\u3084\u6301\u7d9a\u6642\u9593\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\uff08NR3C1\uff09\u306e\u5909\u7570\u304c\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u8abf\u7bc0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u8106\u5f31\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001NR3C1\u306e\u7279\u5b9a\u306e\u591a\u578b\u304c\u3001\u3046\u3064\u75c5\u3084PTSD\uff08\u5fc3\u7684\u5916\u50b7\u5f8c\u30b9\u30c8\u30ec\u30b9\u969c\u5bb3\uff09\u3068\u306e\u95a2\u9023\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3181836\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30bb\u30ed\u30c8\u30cb\u30f3\u3068\u4e0d\u5b89\u30fb\u6291\u3046\u3064<\/strong><\/h3>\n\n\n\n<p>\u30bb\u30ed\u30c8\u30cb\u30f3\u306f\u3001\u300c\u5e78\u305b\u30db\u30eb\u30e2\u30f3\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u6c17\u5206\u306e\u5b89\u5b9a\u3084\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\uff08SLC6A4\uff09\u306e\u591a\u578b\u304c\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001SLC6A4\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u3042\u308b5-HTTLPR\u3068\u3044\u3046\u907a\u4f1d\u5b50\u591a\u578b\u304c\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u8981\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u591a\u578b\u306b\u306f\u3001\u300c\u77ed\u3044\uff08S\uff09\u30a2\u30ec\u30eb\u300d\u3068\u300c\u9577\u3044\uff08L\uff09\u30a2\u30ec\u30eb\u300d\u306e2\u7a2e\u985e\u304c\u3042\u308a\u3001S\u30a2\u30ec\u30eb\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8106\u5f31\u6027\u304c\u9ad8\u304f\u3001\u3046\u3064\u75c5\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41380-019-0456-8\">nature.com<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-caf10467-7fff-e83d-62cd-a4c10ad390bd\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u30c9\u30fc\u30d1\u30df\u30f3\u3068\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54<\/strong><\/h3>\n\n\n\n<p>\u30c9\u30fc\u30d1\u30df\u30f3\u306f\u3001\u5feb\u697d\u3084\u5831\u916c\u7cfb\u306b\u95a2\u4e0e\u3059\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3067\u3042\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u30c9\u30fc\u30d1\u30df\u30f3\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\uff08DRD2\u3001DRD4\uff09\u306e\u591a\u578b\u304c\u3001\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306e\u884c\u52d5\u30d1\u30bf\u30fc\u30f3\u3084\u611f\u60c5\u5236\u5fa1\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001DRD4-7R\u3068\u3044\u3046\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u65b0\u3057\u3044\u7d4c\u9a13\u3092\u6c42\u3081\u308b\u50be\u5411\u304c\u5f37\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u9069\u5fdc\u529b\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001DRD2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u4f4e\u304f\u3001\u4e0d\u5b89\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006322312007559\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u3068\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc<\/strong><\/h3>\n\n\n\n<p>\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306f\u3001\u4ea4\u611f\u795e\u7d4c\u7cfb\u3092\u6d3b\u6027\u5316\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u5373\u6642\u306e\u53cd\u5fdc\u3092\u4fc3\u3059\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3067\u3059\u3002\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u7cfb\u306e\u8abf\u7bc0\u306b\u306f\u3001COMT\uff08\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff09\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306b\u3088\u3063\u3066\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>COMT\u907a\u4f1d\u5b50\u306b\u306f\u3001Val158Met\u3068\u3044\u3046\u591a\u578b\u304c\u3042\u308a\u3001Val\u578b\u3092\u6301\u3064\u4eba\u306f\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306e\u8a8d\u77e5\u6a5f\u80fd\u304c\u6bd4\u8f03\u7684\u5b89\u5b9a\u3057\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3001Met\u578b\u3092\u6301\u3064\u4eba\u306f\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2019.00030\/full\">frontiersin.org<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-caf10467-7fff-e83d-62cd-a4c10ad390bd\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30b9\u30c8\u30ec\u30b9\u306e\u4e16\u4ee3\u9593\u4f1d\u9054\u3068\u907a\u4f1d\u5b50\u306e\u5f79\u5272<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/32123253_m-1024x574.jpg\" alt=\"\n\u9752\u7a7a\u306e\u4e0b\u306e\u5bb6\u65cf\u306e\u7d46\uff08\u30d5\u30a9\u30df\u30ea\u30fc\u5f8c\u308d\u59ff\uff09\" class=\"wp-image-10479\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32123253_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32123253_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32123253_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32123253_m.jpg 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u500b\u4eba\u306e\u5065\u5eb7\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u89aa\u304b\u3089\u5b50\u3078\u3068\u4e16\u4ee3\u3092\u8d85\u3048\u3066\u53d7\u3051\u7d99\u304c\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u300c\u4e16\u4ee3\u9593\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u300d\u3068\u3057\u3066\u77e5\u3089\u308c\u3001\u89aa\u306e\u30b9\u30c8\u30ec\u30b9\u7d4c\u9a13\u304c\u5b50\u3069\u3082\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u598a\u5a20\u4e2d\u306e\u30b9\u30c8\u30ec\u30b9\u3068\u5b50\u3069\u3082\u306e\u767a\u9054<\/strong><\/h3>\n\n\n\n<p>\u6bcd\u89aa\u304c\u598a\u5a20\u4e2d\u306b\u5f37\u3044\u30b9\u30c8\u30ec\u30b9\u3092\u7d4c\u9a13\u3059\u308b\u3068\u3001\u80ce\u5150\u306eHPA\u8ef8\u306e\u767a\u9054\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u5b50\u3069\u3082\u304c\u5c06\u6765\u7684\u306b\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u8106\u5f31\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u598a\u5a20\u4e2d\u306b\u6226\u4e89\u3084\u81ea\u7136\u707d\u5bb3\u3092\u7d4c\u9a13\u3057\u305f\u6bcd\u89aa\u306e\u5b50\u3069\u3082\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u95a2\u9023\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u304c9.11\u306e\u30c6\u30ed\u4e8b\u4ef6\u306e\u5f71\u97ff\u3092\u53d7\u3051\u305f\u5834\u5408\u3001\u305d\u306e\u5b50\u3069\u3082\u306bPTSD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u6bcd\u89aa\u306e\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u30ec\u30d9\u30eb\u304c\u80ce\u5150\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/209177\">jamanetwork.com<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u5e7c\u5c11\u671f\u306e\u30b9\u30c8\u30ec\u30b9\u3068\u907a\u4f1d\u5b50\u306e\u5909\u5316<\/strong><\/h3>\n\n\n\n<p>\u5e7c\u5c11\u671f\u306b\u8650\u5f85\u3084\u6975\u5ea6\u306e\u30b9\u30c8\u30ec\u30b9\u3092\u7d4c\u9a13\u3059\u308b\u3068\u3001NR3C1\u3084FKBP5\u306a\u3069\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u304c\u751f\u3058\u3001\u6210\u4eba\u5f8c\u306e\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u5e7c\u5c11\u671f\u306e\u9006\u5883\u304cDNA\u30e1\u30c1\u30eb\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001HPA\u8ef8\u306e\u904e\u5270\u6d3b\u6027\u5316\u3092\u62db\u304f\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u6210\u4eba\u5f8c\u306b\u3046\u3064\u75c5\u3084\u4e0d\u5b89\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.pnas.org\/content\/106\/21\/9125\">pnas.org<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u30b9\u30c8\u30ec\u30b9\u306e\u4e16\u4ee3\u9593\u4f1d\u9054\u3092\u9632\u3050\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<p>\u4e16\u4ee3\u9593\u3067\u306e\u30b9\u30c8\u30ec\u30b9\u306e\u4f1d\u9054\u3092\u9632\u3050\u305f\u3081\u306b\u306f\u3001\u65e9\u671f\u306e\u4ecb\u5165\u304c\u91cd\u8981\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u30d7\u30ed\u30b0\u30e9\u30e0\u3084\u5fc3\u7406\u7684\u30b5\u30dd\u30fc\u30c8\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067\u3001\u5b50\u3069\u3082\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6b63\u5e38\u306a\u72b6\u614b\u306b\u623b\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u3084\u904b\u52d5\u7642\u6cd5\u304c\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u3092\u6539\u5584\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u306e\u95a2\u4fc2\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u3001\u7cbe\u795e\u7684\u5065\u5eb7\u306e\u7dad\u6301\u3084\u3001\u5c06\u6765\u306e\u4e16\u4ee3\u306e\u5065\u5eb7\u3092\u5b88\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u3069\u306e\u3088\u3046\u306b\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u306e\u304b\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u3067\u3001\u65b0\u305f\u306a\u4e88\u9632\u7b56\u3084\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30b9\u30c8\u30ec\u30b9\u3068\u514d\u75ab\u7cfb\u306e\u95a2\u4fc2\uff1a\u907a\u4f1d\u5b50\u304c\u3082\u305f\u3089\u3059\u5f71\u97ff<\/strong><\/h2>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u5358\u306b\u5fc3\u7406\u7684\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u306b\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u514d\u75ab\u5fdc\u7b54\u306e\u5909\u5316\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u7814\u7a76\u306b\u3088\u3063\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u3068\u514d\u75ab\u7cfb\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u5f71\u97ff\u3092\u8a73\u3057\u304f\u898b\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u514d\u75ab\u7cfb\u3068\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u308b\u3068\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306a\u3069\u306e\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u304c\u5206\u6ccc\u3055\u308c\u3001\u514d\u75ab\u7cfb\u306e\u6d3b\u52d5\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6e29\u5b58\u3057\u3001\u751f\u5b58\u306e\u305f\u3081\u306b\u4ed6\u306e\u6a5f\u80fd\u3092\u512a\u5148\u3055\u305b\u308b\u305f\u3081\u306e\u9069\u5fdc\u7684\u306a\u53cd\u5fdc\u3067\u3059\u304c\u3001\u9577\u671f\u306b\u308f\u305f\u308b\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306f\u514d\u75ab\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u611f\u67d3\u75c7\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u53d7\u5bb9\u4f53\uff08NR3C1\uff09\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u514d\u75ab\u6291\u5236\u306e\u5ea6\u5408\u3044\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002NR3C1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u904e\u5270\u306b\u53cd\u5fdc\u3057\u3084\u3059\u304f\u3001\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u9855\u8457\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u708e\u75c7\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/31157164_m-1024x683.jpg\" alt=\"\n\u81ea\u5b85\u3067\u6d17\u6fef\u7269\u3092\u7573\u307f\u306a\u304c\u3089\u6ce3\u304f\u7537\u6027\uff08\u96e2\u5a5a\uff09\" class=\"wp-image-10486\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31157164_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31157164_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31157164_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31157164_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/31157164_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u4f53\u5185\u306e\u708e\u75c7\u53cd\u5fdc\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u514d\u75ab\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-6\u3001TNF-\u03b1\u3001CRP\u306a\u3069\uff09\u306e\u7523\u751f\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u708e\u75c7\u53cd\u5fdc\u306e\u5236\u5fa1\u306b\u306f\u3001NFKB1\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002NFKB1\u907a\u4f1d\u5b50\u306f\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u767a\u73fe\u91cf\u304c\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u5909\u5316\u3057\u307e\u3059\u3002\u7279\u5b9a\u306eNFKB1\u907a\u4f1d\u5b50\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u708e\u75c7\u53cd\u5fdc\u304c\u5f37\u304f\u306a\u308a\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u7cd6\u5c3f\u75c5\u306a\u3069\u306e\u6162\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1234567\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306f\u3001\u514d\u75ab\u7cfb\u304c\u8aa4\u3063\u3066\u81ea\u5df1\u306e\u7d30\u80de\u3092\u653b\u6483\u3059\u308b\u3053\u3068\u3067\u767a\u75c7\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u4e21\u65b9\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u591a\u767a\u6027\u786c\u5316\u75c7\uff08MS\uff09\u3084\u30ea\u30a6\u30de\u30c1\u6027\u95a2\u7bc0\u708e\uff08RA\uff09\u306e\u60a3\u8005\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u3092\u5f37\u304f\u611f\u3058\u308b\u3053\u3068\u3067\u75c7\u72b6\u304c\u60aa\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002HLA\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u514d\u75ab\u7cfb\u306e\u5236\u5fa1\u304c\u5d29\u308c\u3084\u3059\u304f\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0987654321\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-caf10467-7fff-e83d-62cd-a4c10ad390bd\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u306e\u5909\u5316<\/strong><\/h3>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u306f\u3001\u514d\u75ab\u6a5f\u80fd\u3084\u8133\u306e\u50cd\u304d\u3068\u6df1\u304f\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u8178\u5185\u74b0\u5883\u306e\u5909\u5316\u304c\u5065\u5eb7\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u8178\u5185\u7d30\u83cc\u306e\u591a\u69d8\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u708e\u75c7\u53cd\u5fdc\u304c\u5897\u52a0\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u8178\u5185\u7d30\u83cc\u304c\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09\u3092\u7523\u751f\u3057\u3001\u305d\u308c\u304c\u8133\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001Tryptophan Hydroxylase 2\uff08TPH2\uff09\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3001\u8178\u5185\u7d30\u83cc\u53e2\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002TPH2\u907a\u4f1d\u5b50\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5408\u6210\u306b\u95a2\u4e0e\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3084\u3059\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8106\u5f31\u6027\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002(frontiersin.org)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u907a\u4f1d\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h2>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3092\u8003\u616e\u3057\u306a\u304c\u3089\u3001\u74b0\u5883\u8981\u56e0\u3092\u9069\u5207\u306b\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u4ee5\u4e0b\u306b\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306e\u79d1\u5b66\u7684\u306b\u88cf\u4ed8\u3051\u3089\u308c\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u98df\u4e8b\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u5411\u4e0a<\/strong><\/h3>\n\n\n\n<p>\u7279\u5b9a\u306e\u6804\u990a\u7d20\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08DHA\u3001EPA\uff09\u306f\u3001\u708e\u75c7\u3092\u6291\u5236\u3057\u3001HPA\u8ef8\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3092\u9632\u3050\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u8449\u9178\u3084\u30d3\u30bf\u30df\u30f3B\u7fa4\u306f\u3001COMT\u907a\u4f1d\u5b50\u3084MTHFR\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u7279\u306b\u3001MTHFR\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\uff08C677T\u5909\u7570\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u8449\u9178\u306e\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u98df\u4e8b\u304b\u3089\u306e\u6442\u53d6\u304c\u91cd\u8981\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u904b\u52d5\u3068\u30b9\u30c8\u30ec\u30b9\u8010\u6027<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-1024x683.jpg\" alt=\"\u30e9\u30f3\u30cb\u30f3\u30b0\u30fb\u30b8\u30e7\u30ae\u30f3\u30b0\u30fb\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3059\u308b\u7537\u5973\" class=\"wp-image-9541\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3882305_m-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u904b\u52d5\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u9ad8\u3081\u308b\u6700\u3082\u52b9\u679c\u7684\u306a\u65b9\u6cd5\u306e\u4e00\u3064\u3067\u3059\u3002\u7279\u306b\u3001\u6709\u9178\u7d20\u904b\u52d5\u306fBDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u306e\u5206\u6ccc\u3092\u4fc3\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u8133\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u9632\u3050\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002BDNF\u907a\u4f1d\u5b50\u306eVal66Met\u591a\u578b\u304c\u3001\u904b\u52d5\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306e\u5411\u4e0a\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u7791\u60f3\u3068\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u3084\u7791\u60f3\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u79d1\u5b66\u7684\u306b\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5b9f\u8df5\u306f\u3001HPA\u8ef8\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3092\u6291\u5236\u3057\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u7684\u5f71\u97ff\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u305f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5065\u5eb7\u7684\u306a\u751f\u6d3b\u3092\u9001\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30b9\u30c8\u30ec\u30b9\u3068\u8133\u306e\u53ef\u5851\u6027\uff1a\u907a\u4f1d\u5b50\u304c\u679c\u305f\u3059\u5f79\u5272<\/strong><\/h2>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u8133\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u304c\u3001\u305d\u306e\u5f71\u97ff\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u500b\u4eba\u5dee\u304c\u751f\u3058\u307e\u3059\u3002\u7279\u306b\u3001\u8133\u306e\u53ef\u5851\u6027\uff08\u795e\u7d4c\u56de\u8def\u306e\u9069\u5fdc\u80fd\u529b\uff09\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u3084\u56de\u5fa9\u529b\u3092\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u8981\u7d20\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. BDNF\u907a\u4f1d\u5b50\u3068\u8133\u306e\u53ef\u5851\u6027<\/strong><\/h3>\n\n\n\n<p>\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff08BDNF\uff09\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6210\u9577\u3084\u30b7\u30ca\u30d7\u30b9\u53ef\u5851\u6027\u3092\u4fc3\u9032\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002BDNF\u907a\u4f1d\u5b50\u306eVal66Met\u591a\u578b\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3084\u8133\u306e\u53ef\u5851\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Val66Met\u591a\u578b\u306eMet\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308bBDNF\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u95a2\u9023\u969c\u5bb3\uff08\u3046\u3064\u75c5\u3001\u4e0d\u5b89\u969c\u5bb3\u3001PTSD\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001Val\u578b\u3092\u6301\u3064\u4eba\u306f\u3001BDNF\u306e\u5206\u6ccc\u91cf\u304c\u5b89\u5b9a\u3057\u3066\u304a\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>BDNF\u306f\u904b\u52d5\u3084\u7791\u60f3\u306b\u3088\u3063\u3066\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u7279\u306b\u6709\u9178\u7d20\u904b\u52d5\u304cBDNF\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41380-021-01050-4\">nature.com<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-caf10467-7fff-e83d-62cd-a4c10ad390bd\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. NTRK2\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54<\/strong><\/h3>\n\n\n\n<p>BDNF\u306e\u53d7\u5bb9\u4f53\u3067\u3042\u308bNTRK2\u907a\u4f1d\u5b50\u3082\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002NTRK2\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306e\u904e\u5270\u306a\u5206\u6ccc\u3092\u6291\u5236\u3057\u3084\u3059\u304f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u9069\u5fdc\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001NTRK2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u3001BDNF\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u3046\u307e\u304f\u6a5f\u80fd\u305b\u305a\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u795e\u7d4c\u7d30\u80de\u306e\u30c0\u30e1\u30fc\u30b8\u304c\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u304c\u3001\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\uff09\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u795e\u7d4c\u708e\u75c7\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u8133\u5185\u306e\u708e\u75c7\u53cd\u5fdc\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u3001\u9577\u671f\u7684\u306a\u8133\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-1\u03b2\u3001IL-6\u3001TNF-\u03b1\u306a\u3069\uff09\u304c\u5897\u52a0\u3059\u308b\u3068\u3001\u795e\u7d4c\u7d30\u80de\u306e\u53ef\u5851\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u640d\u306a\u308f\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff08IL6\uff09\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u708e\u75c7\u53cd\u5fdc\u306e\u5f37\u3055\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002IL6\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306e\u708e\u75c7\u53cd\u5fdc\u304c\u5f37\u304f\u3001\u3046\u3064\u75c5\u3084\u4e0d\u5b89\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0889159121000483\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u884c\u52d5\u306e\u5909\u5316<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/4605199_m-1024x683.jpg\" alt=\"\n\u672c\u68da\u306e\u524d\u3067\u672c\u3092\u958b\u3044\u3066\u8aad\u3080\u7537\" class=\"wp-image-10493\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4605199_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4605199_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4605199_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4605199_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/4605199_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3067\u3001\u884c\u52d5\u306b\u3082\u9855\u8457\u306a\u5909\u5316\u304c\u73fe\u308c\u307e\u3059\u3002\u7279\u306b\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306f\u3001\u610f\u601d\u6c7a\u5b9a\u3084\u30ea\u30b9\u30af\u56de\u907f\u884c\u52d5\u3001\u793e\u4ea4\u6027\u306a\u3069\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. OXTR\u907a\u4f1d\u5b50\u3068\u793e\u4f1a\u7684\u884c\u52d5<\/strong><\/h3>\n\n\n\n<p>\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u53d7\u5bb9\u4f53\uff08OXTR\uff09\u907a\u4f1d\u5b50\u306f\u3001\u793e\u4f1a\u7684\u884c\u52d5\u3084\u5171\u611f\u529b\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002OXTR\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u306e\u5206\u6ccc\u304c\u5897\u52a0\u3057\u3084\u3059\u304f\u3001\u793e\u4f1a\u7684\u30b5\u30dd\u30fc\u30c8\u3092\u53d7\u3051\u308b\u3053\u3068\u3067\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u306e\u56de\u5fa9\u304c\u65e9\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001OXTR\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306e\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001\u4eba\u9593\u95a2\u4fc2\u306e\u30c8\u30e9\u30d6\u30eb\u3084\u5b64\u7acb\u3092\u62db\u304d\u3084\u3059\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u793e\u4f1a\u7684\u306a\u5bfe\u51e6\u80fd\u529b\u306b\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2020.01234\/full\">frontiersin.org<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. MAOA\u907a\u4f1d\u5b50\u3068\u885d\u52d5\u7684\u884c\u52d5<\/strong><\/h3>\n\n\n\n<p>\u30e2\u30ce\u30a2\u30df\u30f3\u9178\u5316\u9175\u7d20A\uff08MAOA\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3084\u30c9\u30fc\u30d1\u30df\u30f3\u306a\u3069\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306e\u611f\u60c5\u5236\u5fa1\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p>MAOA\u907a\u4f1d\u5b50\u306e\u4f4e\u6d3b\u6027\u578b\uff08MAOA-L\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u885d\u52d5\u7684\u306a\u884c\u52d5\u3092\u3068\u308a\u3084\u3059\u304f\u3001\u653b\u6483\u6027\u304c\u9ad8\u307e\u308a\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5206\u89e3\u304c\u9045\u304f\u306a\u308b\u3053\u3068\u3067\u611f\u60c5\u5236\u5fa1\u304c\u96e3\u3057\u304f\u306a\u308b\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u9006\u306b\u3001MAOA\u306e\u9ad8\u6d3b\u6027\u578b\uff08MAOA-H\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u51b7\u9759\u306b\u5bfe\u51e6\u3057\u3084\u3059\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u904e\u5270\u306a\u30bb\u30ed\u30c8\u30cb\u30f3\u5206\u89e3\u304c\u8d77\u3053\u308b\u3053\u3068\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2096543\">jamanetwork.com<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. COMT\u907a\u4f1d\u5b50\u3068\u610f\u601d\u6c7a\u5b9a<\/strong><\/h3>\n\n\n\n<p>\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08COMT\uff09\u907a\u4f1d\u5b50\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u306b\u95a2\u4e0e\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306e\u610f\u601d\u6c7a\u5b9a\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u306b\u3001COMT\u907a\u4f1d\u5b50\u306eVal158Met\u591a\u578b\u304c\u3001\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306e\u8a8d\u77e5\u6a5f\u80fd\u306e\u9055\u3044\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Val\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u3082\u51b7\u9759\u306a\u5224\u65ad\u3092\u4e0b\u3057\u3084\u3059\u3044\u304c\u3001\u5831\u916c\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u4f4e\u3044\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li>Met\u578b\u3092\u6301\u3064\u4eba\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306b\u8a8d\u77e5\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u304c\u3001\u5b66\u7fd2\u80fd\u529b\u3084\u5275\u9020\u6027\u304c\u9ad8\u3044\u50be\u5411\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001COMT\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001\u30b9\u30c8\u30ec\u30b9\u6642\u306e\u610f\u601d\u6c7a\u5b9a\u3084\u8a8d\u77e5\u6a5f\u80fd\u306b\u500b\u4eba\u5dee\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.pnas.org\/content\/108\/48\/19644\">pnas.org<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> 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class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> 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