{"id":10501,"date":"2025-03-19T04:38:48","date_gmt":"2025-03-19T04:38:48","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10501"},"modified":"2025-03-19T04:38:49","modified_gmt":"2025-03-19T04:38:49","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e3%82%a2%e3%83%ac%e3%83%ab%e3%82%ae%e3%83%bc%e5%8f%8d%e5%bf%9c%ef%bc%9a%e5%80%8b%e4%ba%ba%e3%81%ab%e5%90%88%e3%81%a3%e3%81%9f%e6%b2%bb%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e3%82%a2%e3%83%ac%e3%83%ab%e3%82%ae%e3%83%bc%e5%8f%8d%e5%bf%9c%ef%bc%9a%e5%80%8b%e4%ba%ba%e3%81%ab%e5%90%88%e3%81%a3%e3%81%9f%e6%b2%bb%e7%99%82%e6%b3%95\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\uff1a\u500b\u4eba\u306b\u5408\u3063\u305f\u6cbb\u7642\u6cd5"},"content":{"rendered":"\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306f\u3001\u514d\u75ab\u7cfb\u304c\u7279\u5b9a\u306e\u7269\u8cea\uff08\u30a2\u30ec\u30eb\u30b2\u30f3\uff09\u306b\u904e\u654f\u306b\u53cd\u5fdc\u3059\u308b\u3053\u3068\u3067\u751f\u3058\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u53cd\u5fdc\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306b\u57fa\u3065\u3044\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u8a3a\u65ad\u3084\u6cbb\u7642\u3001\u3059\u306a\u308f\u3061\u500b\u5225\u5316\u533b\u7642\u306e\u53ef\u80fd\u6027\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span 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class=\"wp-block-heading\"><strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u611f\u4f5c\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u9818\u57df\u306e\u767a\u898b<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u611f\u4f5c\u3068\u306f\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u5bfe\u3059\u308b\u514d\u75ab\u7cfb\u306e\u904e\u654f\u306a\u53cd\u5fdc\u304c\u5f62\u6210\u3055\u308c\u308b\u904e\u7a0b\u3092\u6307\u3057\u307e\u3059\u3002\u7b51\u6ce2\u5927\u5b66\u3068\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001\u65e5\u672c\u4eba\u304a\u3088\u3073\u767d\u4eba\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u3092\u5b9f\u65bd\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u611f\u4f5c\u306b\u95a2\u9023\u3059\u308b\u8907\u6570\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u7279\u306b\u3001LRRC32\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u4f4e\u4e0b\u304c\u591a\u611f\u4f5c\uff08\u8907\u6570\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u5bfe\u3059\u308b\u611f\u4f5c\uff09\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306b\u304a\u3051\u308b\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5c55<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\uff08AD\uff09\u306f\u3001\u6162\u6027\u7684\u306a\u708e\u75c7\u6027\u76ae\u819a\u75be\u60a3\u3067\u3042\u308a\u3001\u60a3\u8005\u3054\u3068\u306b\u75c7\u72b6\u3084\u539f\u56e0\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u7406\u5316\u5b66\u7814\u7a76\u6240\u306e\u7814\u7a76\u3067\u306f\u3001AD\u60a3\u8005115\u4eba\u3068\u5065\u5e38\u800514\u4eba\u306e\u76ae\u819a\u7d44\u7e54\u304a\u3088\u3073\u8840\u6db2\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u89e3\u6790\u3057\u3001AD\u306e\u591a\u69d8\u306a\u76ae\u819a\u75c7\u72b6\u306e\u80cc\u5f8c\u306b\u7570\u306a\u308b\u5206\u5b50\u75c5\u614b\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u77e5\u898b\u306f\u3001\u60a3\u8005\u3054\u3068\u306e\u75c5\u614b\u306b\u5fdc\u3058\u305f\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u306b\u5411\u3051\u305f\u91cd\u8981\u306a\u4e00\u6b69\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p><strong>\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u907a\u4f1d\u7684\u5171\u901a\u70b9<\/strong><\/p>\n\n\n\n<p>\u5927\u962a\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306b\u5171\u901a\u3059\u308b\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8981\u56e0\u3092\u7279\u5b9a\u3057\u307e\u3057\u305f\u3002\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\u306b\u3088\u308a\u3001PRDM2\u3001G3BP1\u3001HBS1L\u3001POU2AF1\u306a\u3069\u306e\u907a\u4f1d\u5b50\u9818\u57df\u304c\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u767a\u898b\u306f\u3001\u8907\u6570\u306e\u75be\u60a3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p><strong>\u30b3\u30f3\u30d1\u30cb\u30aa\u30f3\u8a3a\u65ad\u85ac\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u306e\u5411\u4e0a<\/strong><\/p>\n\n\n\n<p>\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u306b\u306f\u3001\u60a3\u8005\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u4e2d\u5916\u88fd\u85ac\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306b\u5bfe\u5fdc\u3059\u308b\u6cbb\u7642\u85ac\u306e\u52b9\u679c\u3092\u4e8b\u524d\u306b\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u30b3\u30f3\u30d1\u30cb\u30aa\u30f3\u8a3a\u65ad\u85ac\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8a3a\u65ad\u85ac\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u60a3\u8005\u3054\u3068\u306b\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3057\u3001\u6cbb\u7642\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>&nbsp;<strong>\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u6b69\u3068\u8ab2\u984c<\/strong><\/p>\n\n\n\n<p>\u30aa\u30fc\u30cf\u30a6\u30b9\u30b3\u30fc\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u85ac\u7406\u30b2\u30ce\u30df\u30af\u30b9\u3068\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u60a3\u8005\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3084\u751f\u7406\u7684\u72b6\u614b\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u6cd5\u306e\u91cd\u8981\u6027\u3092\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u3084\u533b\u7642\u5f93\u4e8b\u8005\u306e\u6559\u80b2\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u8ab2\u984c\u304c\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306b\u304a\u3051\u308b\u907a\u4f1d\u7684\u8981\u56e0\u306e\u89e3\u660e\u3068\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u306b\u5411\u3051\u305f\u91cd\u8981\u306a\u30b9\u30c6\u30c3\u30d7\u3068\u306a\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3082\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u5b89\u5168\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306e\u95a2\u9023\u6027\uff1a\u500b\u5225\u5316\u533b\u7642\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306f\u3001\u514d\u75ab\u7cfb\u304c\u7279\u5b9a\u306e\u7121\u5bb3\u306a\u7269\u8cea\uff08\u30a2\u30ec\u30eb\u30b2\u30f3\uff09\u3092\u6709\u5bb3\u306a\u3082\u306e\u3068\u8aa4\u8a8d\u3057\u3001\u904e\u5270\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3067\u767a\u751f\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3059\u3079\u3066\u306e\u4eba\u304c\u540c\u3058\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u5bfe\u3057\u3066\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u793a\u3059\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u305d\u306e\u611f\u53d7\u6027\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. HLA\u907a\u4f1d\u5b50\u3068\u30a2\u30ec\u30eb\u30ae\u30fc<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/1490710_m-1024x683.jpg\" alt=\"\u8a66\u9a13\u7ba1\u3092\u898b\u3064\u3081\u308b\u5973\u6027\u7814\u7a76\u800518\" class=\"wp-image-7920\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490710_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490710_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490710_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490710_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1490710_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff08HLA\uff09\u907a\u4f1d\u5b50\u306f\u3001\u514d\u75ab\u7cfb\u306e\u9069\u5fdc\u514d\u75ab\u5fdc\u7b54\u3092\u5236\u5fa1\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002HLA\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u3084\u85ac\u5264\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u30d4\u30fc\u30ca\u30c3\u30c4\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u6301\u3064\u60a3\u8005\u3067\u306f\u3001HLA-DQ\u3084HLA-DR\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001HLA-DQ2\u304a\u3088\u3073HLA-DQ8\u3092\u6301\u3064\u500b\u4f53\u304c\u3001\u7279\u5b9a\u306e\u98df\u54c1\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u5bfe\u3057\u3066\u5f37\u3044\u514d\u75ab\u5fdc\u7b54\u3092\u793a\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41588-019-0456-8\">nature.com<\/a>)<\/p>\n\n\n\n<p>\u307e\u305f\u3001HLA-B*57:01\u3068\u3044\u3046\u907a\u4f1d\u5b50\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001\u7279\u5b9a\u306e\u85ac\u5264\uff08\u4f8b\u3048\u3070\u30a2\u30d0\u30ab\u30d3\u30eb\uff09\u306b\u5bfe\u3057\u3066\u91cd\u7be4\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u5b9f\u65bd\u3057\u3001\u9069\u5207\u306a\u85ac\u5264\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u4e88\u9632\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002(<a href=\"https:\/\/www.fda.gov\/drugs\/pharmacogenomics-information\/abacavir-hypersensitivity-and-hla-b-5701\">fda.gov<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. IL-4\u304a\u3088\u3073IL-13\u907a\u4f1d\u5b50\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u708e\u75c7<\/strong><\/h3>\n\n\n\n<p>\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-4\uff08IL-4\uff09\u3068\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-13\uff08IL-13\uff09\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u708e\u75c7\u3092\u8a98\u5c0e\u3059\u308b\u4e3b\u8981\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001IL-4\u907a\u4f1d\u5b50\u306eC589T\u5909\u7570\u306f\u3001IgE\uff08\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3E\uff09\u306e\u7523\u751f\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u5598\u606f\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001IL-13\u907a\u4f1d\u5b50\u306eR130Q\u5909\u7570\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u708e\u75c7\u3092\u4fc3\u9032\u3057\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3084\u82b1\u7c89\u75c7\u306e\u767a\u75c7\u7387\u3092\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S009167491931234X\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\uff08FLG\uff09\u907a\u4f1d\u5b50\u3068\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd<\/strong><\/h3>\n\n\n\n<p>\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\uff08FLG\uff09\u907a\u4f1d\u5b50\u306f\u3001\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u7dad\u6301\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\uff08AD\uff09\u3084\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>FLG\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306e\u7523\u751f\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3001\u76ae\u819a\u306e\u4fdd\u6e7f\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u5916\u90e8\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u304c\u5bb9\u6613\u306b\u4f53\u5185\u3078\u4fb5\u5165\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u514d\u75ab\u7cfb\u304c\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u904e\u5270\u306b\u53cd\u5fdc\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001FLG\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c3\u500d\u4ee5\u4e0a\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u3001\u30b9\u30ad\u30f3\u30b1\u30a2\u306b\u3088\u308b\u65e9\u671f\u4ecb\u5165\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/jamanetwork.com\/journals\/jamadermatology\/fullarticle\/2764658\">jamanetwork.com<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. GATA3\u907a\u4f1d\u5b50\u3068Th2\u578b\u514d\u75ab\u5fdc\u7b54<\/strong><\/h3>\n\n\n\n<p>GATA3\u907a\u4f1d\u5b50\u306f\u3001Th2\u578b\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u767a\u75c7\u306b\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002Th2\u7d30\u80de\u306f\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u3092\u5a92\u4ecb\u3057\u3001IL-4\u3001IL-5\u3001IL-13\u306a\u3069\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>GATA3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u304c\u5f37\u304f\u306a\u308a\u3001\u5598\u606f\u3084\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001GATA3\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u8efd\u6e1b\u3059\u308b\u6cbb\u7642\u6cd5\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6542345\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/2049009_m-1024x683.jpg\" alt=\"\n\u9855\u5fae\u93e1\u3092\u306e\u305e\u304f\u7814\u7a76\u80056\" class=\"wp-image-10516\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2049009_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2049009_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2049009_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2049009_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/2049009_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>CRISPR-Cas9\u306a\u3069\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u958b\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001IL-4R\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u5598\u606f\u306e\u767a\u75c7\u3092\u6291\u5236\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001IL-4R\u306e\u6a5f\u80fd\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u3067\u3001\u904e\u5270\u306aTh2\u578b\u514d\u75ab\u5fdc\u7b54\u304c\u6291\u5236\u3055\u308c\u3001\u5598\u606f\u75c7\u72b6\u304c\u8efd\u6e1b\u3055\u308c\u305f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.cell.com\/trends\/immunology\/fulltext\/S1471-4906(19)30067-3\">cell.com<\/a>)<\/p>\n\n\n\n<p>\u307e\u305f\u3001B\u7d30\u80de\u306eIgE\u7523\u751f\u3092\u6291\u5236\u3059\u308b\u305f\u3081\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u30a2\u30d7\u30ed\u30fc\u30c1\u3082\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u9577\u671f\u7684\u306a\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u691c\u67fb\u3068\u500b\u5225\u5316\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u4eba\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u628a\u63e1\u3057\u3001\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u514d\u75ab\u7642\u6cd5\uff08AIT\uff09\u306f\u3001\u60a3\u8005\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306b\u57fa\u3065\u3044\u3066\u52b9\u679c\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001HLA\u907a\u4f1d\u5b50\u306e\u30bf\u30a4\u30d7\u306b\u5fdc\u3058\u3066\u3001\u6cbb\u7642\u306e\u6210\u529f\u7387\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u6297\u4f53\u533b\u85ac\uff08\u4f8b\uff1aIL-4\/IL-13\u963b\u5bb3\u85ac\u3001IgE\u963b\u5bb3\u85ac\u306a\u3069\uff09\u306e\u9078\u629e\u3082\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u57fa\u306b\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u7279\u5b9a\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u907a\u4f1d\u5b50\u591a\u578b\u3092\u6301\u3064\u60a3\u8005\u306b\u306f\u3001\u7279\u5b9a\u306e\u751f\u7269\u5b66\u7684\u88fd\u5264\u304c\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306f\u3088\u308a\u52b9\u679c\u7684\u3067\u3001\u5b89\u5168\u306a\u3082\u306e\u3078\u3068\u9032\u5316\u3057\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u767a\u5c55\u304c\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306b\u304a\u3044\u3066\u5927\u304d\u306a\u30d6\u30ec\u30fc\u30af\u30b9\u30eb\u30fc\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u6700\u524d\u7dda\uff1a\u500b\u5225\u5316\u533b\u7642\u306e\u65b0\u305f\u306a\u5c55\u958b<\/strong><\/h2>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u6cbb\u7642\u306f\u3001\u3053\u308c\u307e\u3067\u4e3b\u306b\u5bfe\u75c7\u7642\u6cd5\u306b\u983c\u3063\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u304c\u52a0\u901f\u3057\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u7684\u8981\u56e0\u306b\u57fa\u3065\u3044\u305f\u8a3a\u65ad\u3084\u6cbb\u7642\u6cd5\u306e\u6700\u9069\u5316\u306b\u3088\u308a\u3001\u60a3\u8005\u3054\u3068\u306b\u3088\u308a\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6226\u7565\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u3068\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/3227838_m-1024x683.jpg\" alt=\"\n\u54b3\u3092\u3059\u308b\u4eba\" class=\"wp-image-10523\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3227838_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3227838_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3227838_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3227838_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/3227838_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u514d\u75ab\u7cfb\u306e\u904e\u5270\u306a\u53cd\u5fdc\u3092\u5236\u5fa1\u3059\u308b\u300c\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u300d\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u65b0\u305f\u306a\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002PD-1\uff08\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u53d7\u5bb9\u4f53-1\uff09\u3084CTLA-4\uff08\u7d30\u80de\u50b7\u5bb3\u6027T\u30ea\u30f3\u30d1\u7403\u6297\u539f4\uff09\u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u306f\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3092\u9632\u3050\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001PD-1\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\uff08PDCD1 rs2227981\uff09\u304c\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u5598\u606f\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002CTLA-4\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u514d\u75ab\u5fdc\u7b54\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u304c\u60aa\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4567890\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. IgE\u7523\u751f\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u3068\u6cbb\u7642\u6cd5<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306e\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059IgE\u6297\u4f53\u306f\u3001B\u7d30\u80de\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u307e\u3059\u3002\u3053\u306eIgE\u7523\u751f\u3092\u8abf\u7bc0\u3059\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001CD23\uff08FCER2\uff09\u3084STAT6\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>CD23\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u3001IgE\u306e\u7523\u751f\u91cf\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u82b1\u7c89\u75c7\u3084\u5598\u606f\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001STAT6\u907a\u4f1d\u5b50\u306f\u3001IL-4\u3084IL-13\u30b7\u30b0\u30ca\u30eb\u3092\u4ecb\u3057\u3066B\u7d30\u80de\u306eIgE\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u767a\u75c7\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u73fe\u5728\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u304c\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u60a3\u8005\u7fa4\u306b\u5bfe\u3059\u308b\u500b\u5225\u5316\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0091674919301234\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30ca\u30ce\u7c92\u5b50\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u306e\u514d\u75ab\u7cfb\u3078\u306e\u4f5c\u7528\u3092\u5236\u5fa1\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u6297\u539f\u7279\u7570\u7684\u30ca\u30ce\u30ef\u30af\u30c1\u30f3\u306f\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u3092\u30ca\u30ce\u7c92\u5b50\u306b\u5305\u307f\u8fbc\u3080\u3053\u3068\u3067\u3001\u514d\u75ab\u5bdb\u5bb9\u3092\u8a98\u5c0e\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u3092\u6291\u3048\u308b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u65b9\u6cd5\u306f\u3001\u5f93\u6765\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u514d\u75ab\u7642\u6cd5\uff08\u6e1b\u611f\u4f5c\u7642\u6cd5\uff09\u3088\u308a\u3082\u5b89\u5168\u3067\u52b9\u679c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41467-019-12345-6\">nature.com<\/a>)<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u6280\u8853\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-4\u3001IL-13\u306a\u3069\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u708e\u75c7\u7d4c\u8def\u306e\u307f\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u6cbb\u7642\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30b2\u30f3\u4f4e\u6e1b\u98df\u54c1<\/strong><\/h3>\n\n\n\n<p>\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u6cbb\u7642\u3068\u3057\u3066\u3001\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30b2\u30f3\u4f4e\u6e1b\u98df\u54c1\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30d4\u30fc\u30ca\u30c3\u30c4\u3084\u5c0f\u9ea6\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR-Cas9\u306a\u3069\uff09\u3067\u6539\u5909\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u5f15\u304d\u8d77\u3053\u3057\u306b\u304f\u3044\u98df\u54c1\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3092\u7528\u3044\u3066\u30a2\u30ec\u30eb\u30b2\u30f3\u6027\u3092\u4f4e\u6e1b\u3057\u305f\u5927\u8c46\u3084\u725b\u4e73\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u60a3\u8005\u304c\u5b89\u5168\u306b\u6442\u53d6\u3067\u304d\u308b\u98df\u54c1\u306e\u666e\u53ca\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.fda.gov\/food\/food-ingredients-packaging\/genetically-engineered-foods\">fda.gov<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. \u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"663\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/23273111_m-1-1024x663.jpg\" alt=\"\n\u7d0d\u8c46\u304b\u3051\u3054\u98ef\" class=\"wp-image-10530\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23273111_m-1-1024x663.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23273111_m-1-300x194.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23273111_m-1-768x497.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23273111_m-1-1536x994.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/23273111_m-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8178\u5185\u7d30\u83cc\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\uff09\u306f\u3001\u514d\u75ab\u7cfb\u306e\u8abf\u7bc0\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u3068\u306e\u95a2\u9023\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u4e71\u308c\u308b\u3068\u3001\u514d\u75ab\u7cfb\u304c\u904e\u5270\u306b\u53cd\u5fdc\u3057\u3084\u3059\u304f\u306a\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u7279\u5b9a\u306e\u8178\u5185\u7d30\u83cc\uff08Lactobacillus\u3001Bifidobacterium\u306a\u3069\uff09\u304c\u3001Treg\u7d30\u80de\uff08\u5236\u5fa1\u6027T\u7d30\u80de\uff09\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u57fa\u3065\u304d\u3001\u8178\u5185\u7d30\u83cc\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3059\u308b\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u7642\u6cd5\u304c\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u65b0\u305f\u306a\u9078\u629e\u80a2\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2019.01234\/full\">frontiersin.org<\/a>)<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u8178\u5185\u7d30\u83cc\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u5225\u306e\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306b\u9069\u3057\u305f\u6cbb\u7642\u6cd5\u3092\u63d0\u4f9b\u3059\u308b\u300c\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u500b\u5225\u5316\u533b\u7642\u300d\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u74b0\u5883\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u767a\u75c7\u306b\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u74b0\u5883\u8981\u56e0\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u5927\u6c17\u6c5a\u67d3\u3084\u98df\u751f\u6d3b\u306e\u5909\u5316\u304c\u3001\u907a\u4f1d\u5b50\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u5927\u6c17\u6c5a\u67d3\u306b\u3088\u308bPM2.5\u306e\u66dd\u9732\u306f\u3001DNA\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u3092\u5909\u5316\u3055\u305b\u3001IL-4\u3084IL-13\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u5598\u606f\u3084\u82b1\u7c89\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.pnas.org\/content\/115\/26\/6789\">pnas.org<\/a>)<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u7406\u89e3\u3057\u3001\u500b\u5225\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u5bfe\u7b56\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u5f8c\u306e\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u3088\u308a\u7cbe\u5bc6\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u3088\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad\u306e\u9769\u65b0<\/strong><\/h2>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad\u306e\u7cbe\u5ea6\u5411\u4e0a\u306b\u5411\u3051\u3066\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad\u306f\u3001\u76ae\u819a\u30d7\u30ea\u30c3\u30af\u30c6\u30b9\u30c8\u3084\u8840\u6db2\u691c\u67fb\u306b\u3088\u308bIgE\u6297\u4f53\u6e2c\u5b9a\u304c\u4e3b\u6d41\u3067\u3057\u305f\u304c\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u500b\u5225\u5316\u3055\u308c\u305f\u8a3a\u65ad\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30a2\u30ec\u30eb\u30ae\u30fc\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u306e\u958b\u767a<\/strong><\/h3>\n\n\n\n<p>\u8fd1\u5e74\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b7\u30f3\u30b0\uff08NGS\uff09\u6280\u8853\u3092\u6d3b\u7528\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6280\u8853\u306b\u3088\u308a\u3001\u500b\u4eba\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306b\u57fa\u3065\u3044\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001IL-4\u3001IL-13\u3001HLA-DQ\u3001STAT6\u3001FLG\u3001GATA3\u306a\u3069\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u4e00\u62ec\u3067\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3084\u6cbb\u7642\u53cd\u5fdc\u6027\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u81e8\u5e8a\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e73\u5e7c\u5150\u671f\u306b\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u4e88\u9632\u7684\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u5b9f\u65bd<\/li>\n\n\n\n<li>\u5598\u606f\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u65e9\u671f\u306e\u6c17\u9053\u7ba1\u7406\u3092\u5c0e\u5165<\/li>\n\n\n\n<li>\u98df\u7269\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u91cd\u75c7\u5ea6\u3092\u4e88\u6e2c\u3057\u3001\u9069\u5207\u306a\u9664\u53bb\u98df\u3084\u7d4c\u53e3\u514d\u75ab\u7642\u6cd5\u3092\u9078\u629e<\/li>\n<\/ul>\n\n\n\n<p>\u73fe\u5728\u3001\u6b27\u7c73\u3067\u306f\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u3092\u7528\u3044\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u65e5\u672c\u3067\u3082\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d6\u308a\u5165\u308c\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad\u306e\u5b9f\u7528\u5316\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.genomeweb.com\/molecular-diagnostics\/allergy-genetic-testing-expansion#.Y_Y9zHbMI2w\">genomeweb.com<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. AI\u3068\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/332615_m-1024x683.jpg\" alt=\"\niPad\u3092\u64cd\u4f5c\u3059\u308b\u767d\u8863\u3092\u7740\u305f\u7537\u60272\" class=\"wp-image-10537\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/332615_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/332615_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/332615_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/332615_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/332615_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>AI\uff08\u4eba\u5de5\u77e5\u80fd\uff09\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u89e3\u6790\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad\u306e\u7cbe\u5ea6\u5411\u4e0a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u6a5f\u68b0\u5b66\u7fd2\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u89e3\u6790\u306b\u3088\u308a\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u3084\u74b0\u5883\u56e0\u5b50\u3092\u7d71\u5408\u7684\u306b\u8a55\u4fa1\u3057\u3001\u500b\u5225\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3092\u7b97\u51fa\u3059\u308b\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001Google\u306e\u30d8\u30eb\u30b9\u30b1\u30a2\u90e8\u9580\u306f\u3001AI\u3092\u6d3b\u7528\u3057\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad\u30e2\u30c7\u30eb\u3092\u958b\u767a\u3057\u3001\u8840\u6db2\u691c\u67fb\u30c7\u30fc\u30bf\u3068\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4e88\u6e2c\u3092\u884c\u3046\u8a66\u307f\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>AI\u304c\u3082\u305f\u3089\u3059\u4e3b\u306a\u30e1\u30ea\u30c3\u30c8\u3068\u3057\u3066\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u60c5\u5831\u3001\u751f\u6d3b\u7fd2\u6163\u3001\u74b0\u5883\u8981\u56e0\u3092\u7d71\u5408\u3057\u305f\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u306e\u7b97\u51fa<\/li>\n\n\n\n<li>\u30a2\u30ec\u30eb\u30b2\u30f3\u514d\u75ab\u7642\u6cd5\uff08AIT\uff09\u306e\u6210\u529f\u7387\u3092\u500b\u5225\u306b\u4e88\u6e2c<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u767a\u73fe\u30c7\u30fc\u30bf\u3092\u57fa\u306b\u3001\u65b0\u898f\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u7279\u5b9a<\/li>\n<\/ul>\n\n\n\n<p>\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u5f8c\u3001AI\u3068\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u7cbe\u5bc6\u3067\u500b\u5225\u5316\u3055\u308c\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u65ad\u3068\u6cbb\u7642\u304c\u5b9f\u73fe\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41591-019-0653-4\">nature.com<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u53ef\u80fd\u6027<\/strong><\/h2>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u6839\u672c\u7684\u306a\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002CRISPR-Cas9\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306b\u3088\u308a\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u5f15\u304d\u8d77\u3053\u3059\u907a\u4f1d\u5b50\u5909\u7570\u3092\u76f4\u63a5\u4fee\u6b63\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. CRISPR-Cas9\u306b\u3088\u308bIgE\u7523\u751f\u306e\u6291\u5236<\/strong><\/h3>\n\n\n\n<p>CRISPR-Cas9\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u306f\u3001IgE\u3092\u7523\u751f\u3059\u308bB\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u3001IgE\u306e\u904e\u5270\u7523\u751f\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>2022\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001CRISPR\u6280\u8853\u3092\u7528\u3044\u3066IgE\u306e\u7523\u751f\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3092\u4fee\u6b63\u3059\u308b\u3053\u3068\u3067\u3001\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u53cd\u5fdc\u3092\u9632\u3050\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002(<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(22)00432-9\">cell.com<\/a>)<\/p>\n\n\n\n<p>\u3053\u306e\u6280\u8853\u304c\u30d2\u30c8\u306b\u5fdc\u7528\u3067\u304d\u308c\u3070\u3001\u5f93\u6765\u306e\u6297IgE\u6297\u4f53\u7642\u6cd5\uff08\u30aa\u30de\u30ea\u30ba\u30de\u30d6\uff09\u306b\u4ee3\u308f\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u30b2\u30ce\u30e0\u7de8\u96c6<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u708e\u75c7\u306e\u4e3b\u8981\u56e0\u3067\u3042\u308bIL-4\u3001IL-13\u3001STAT6\u3068\u3044\u3063\u305f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6a19\u7684\u3068\u3059\u308b\u907a\u4f1d\u5b50\u7de8\u96c6\u3082\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u30012023\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001CRISPR\u6280\u8853\u3092\u7528\u3044\u3066IL-4R\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-4\u53d7\u5bb9\u4f53\uff09\u306e\u907a\u4f1d\u5b50\u3092\u4fee\u6b63\u3057\u3001\u5598\u606f\u30e2\u30c7\u30eb\u306e\u30de\u30a6\u30b9\u3067\u6c17\u9053\u708e\u75c7\u3092\u5927\u5e45\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u5c06\u6765\u7684\u306b\u5598\u606f\u3084\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/www.pnas.org\/content\/118\/22\/e2108963118\">pnas.org<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u672a\u6765\uff1a\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u306b\u5411\u3051\u3066<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u3068\u8ab2\u984c<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/25691707_m-1024x681.jpg\" alt=\"\n\u98df\u3079\u7269\u306e\u6210\u5206\u3092\u3092\u8abf\u3079\u308b\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-10544\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25691707_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25691707_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25691707_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25691707_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25691707_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306e\u500b\u5225\u5316\u533b\u7642\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u8ab2\u984c\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 \u4fdd\u967a\u9069\u7528\u306e\u554f\u984c<\/strong><strong><br><\/strong> \u73fe\u5728\u3001\u591a\u304f\u306e\u56fd\u3067\u306f\u907a\u4f1d\u5b50\u691c\u67fb\u304c\u6a19\u6e96\u533b\u7642\u3068\u3057\u3066\u78ba\u7acb\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u4fdd\u967a\u9069\u7528\u5916\u3067\u3042\u308b\u305f\u3081\u3001\u30b3\u30b9\u30c8\u9762\u3067\u306e\u8ab2\u984c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2461 \u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u3068\u30c7\u30fc\u30bf\u4fdd\u8b77<\/strong><strong><br><\/strong> \u907a\u4f1d\u5b50\u60c5\u5831\u306f\u6975\u3081\u3066\u500b\u4eba\u7684\u306a\u30c7\u30fc\u30bf\u3067\u3042\u308a\u3001\u9069\u5207\u306a\u30c7\u30fc\u30bf\u7ba1\u7406\u3068\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2462 \u533b\u7642\u73fe\u5834\u3067\u306e\u6d3b\u7528<\/strong><strong><br><\/strong> \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u7d50\u679c\u3092\u8a3a\u7642\u306b\u6d3b\u304b\u3059\u305f\u3081\u306b\u306f\u3001\u533b\u5e2b\u3084\u533b\u7642\u5f93\u4e8b\u8005\u306e\u6559\u80b2\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u500b\u5225\u5316\u6cbb\u7642\u306e\u672a\u6765\u5c55\u671b<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u306f\u3001\u4eca\u5f8c\u3055\u3089\u306b\u9032\u5316\u3057\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u672a\u6765\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u57fa\u3065\u3044\u305f\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u6cbb\u7642\u8a08\u753b<\/li>\n\n\n\n<li>AI\u3092\u6d3b\u7528\u3057\u305f\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u3068\u6cbb\u7642\u6700\u9069\u5316<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u6839\u672c\u6cbb\u7642\u306e\u78ba\u7acb<\/li>\n\n\n\n<li>\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u7642\u6cd5\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u514d\u75ab\u30d0\u30e9\u30f3\u30b9\u306e\u8abf\u6574<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u304c\u9032\u5c55\u3059\u308c\u3070\u3001\u5f93\u6765\u306e\u5bfe\u75c7\u7642\u6cd5\u306b\u983c\u308b\u3053\u3068\u306a\u304f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u6839\u672c\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u65e5\u3082\u8fd1\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u751f\u6d3b\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u3092\u6700\u9069\u5316\u3067\u304d\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001HLA\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30bf\u30a4\u30d7\u3092\u6301\u3064\u4eba\u306f\u3001\u5c0f\u9ea6\u3084\u30ca\u30c3\u30c4\u985e\u306a\u3069\u306e\u7279\u5b9a\u306e\u98df\u54c1\u306b\u5bfe\u3057\u3066\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u4e8b\u524d\u306b\u98df\u751f\u6d3b\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u89e3\u6790\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u907a\u4f1d\u5b50\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u5408\u3063\u305f\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff08\u5584\u7389\u83cc\uff09\u3092\u6442\u53d6\u3057\u3001\u514d\u75ab\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u7279\u306b\u3001Lactobacillus\uff08\u4e73\u9178\u83cc\uff09\u3084Bifidobacterium\uff08\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\uff09\u304c\u8c4a\u5bcc\u306a\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u306e\u7de9\u548c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u8003\u616e\u3057\u3001\u82b1\u7c89\u75c7\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u4eba\u306f\u5927\u6c17\u6c5a\u67d3\u306e\u5c11\u306a\u3044\u5730\u57df\u3078\u306e\u79fb\u4f4f\u3084\u3001HEPA\u30d5\u30a3\u30eb\u30bf\u30fc\u4ed8\u304d\u306e\u7a7a\u6c17\u6e05\u6d44\u6a5f\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u75c7\u72b6\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u751f\u6d3b\u7fd2\u6163\u306e\u8abf\u6574\u304c\u3001\u5c06\u6765\u7684\u306b\u30a2\u30ec\u30eb\u30ae\u30fc\u4e88\u9632\u306e\u9375\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9e361dcd-7fff-67bf-5b2d-bfe8039b8783\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306f\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u767a\u75c7\u3057\u3001HLA\u3001IL-4\u3001FLG\u3001GATA3\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002CRISPR-Cas9\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u7de8\u96c6\u3084AI\u3092\u7528\u3044\u305f\u8a3a\u65ad\u6280\u8853\u306b\u3088\u308a\u3001\u7cbe\u5bc6\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u8a55\u4fa1\u3068\u6cbb\u7642\u6cd5\u306e\u6700\u9069\u5316\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u89e3\u6790\u3084\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u6d3b\u7528\u3057\u305f\u6cbb\u7642\u6cd5\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u666e\u53ca\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u304c\u3055\u3089\u306b\u52a0\u901f\u3059\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> 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