{"id":10552,"date":"2025-03-19T04:59:39","date_gmt":"2025-03-19T04:59:39","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10552"},"modified":"2025-03-19T04:59:40","modified_gmt":"2025-03-19T04:59:40","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e9%85%b8%e5%8c%96%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%ef%bc%9a%e3%82%a8%e3%82%a4%e3%82%b8%e3%83%b3%e3%82%b0%e3%82%92%e9%98%b2%e3%81%90%e3%83%92%e3%83%b3%e3%83%88","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e9%85%b8%e5%8c%96%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%ef%bc%9a%e3%82%a8%e3%82%a4%e3%82%b8%e3%83%b3%e3%82%b0%e3%82%92%e9%98%b2%e3%81%90%e3%83%92%e3%83%b3%e3%83%88\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff1a\u30a8\u30a4\u30b8\u30f3\u30b0\u3092\u9632\u3050\u30d2\u30f3\u30c8"},"content":{"rendered":"\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u8001\u5316\u3084\u95a2\u9023\u75be\u60a3\u306e\u4e3b\u8981\u306a\u8981\u56e0\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306e\u904e\u5270\u306a\u751f\u6210\u306f\u3001DNA\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u8102\u8cea\u306a\u3069\u306e\u7d30\u80de\u6210\u5206\u3092\u640d\u50b7\u3057\u3001\u7d30\u80de\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3084\u7d30\u80de\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u640d\u50b7\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3001\u8001\u5316\u73fe\u8c61\u3084\u304c\u3093\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u6027\u3001\u305d\u3057\u3066\u30a8\u30a4\u30b8\u30f3\u30b0\u3092\u9632\u3050\u305f\u3081\u306e\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u63a2\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-fb65287a-7fff-1f27-32fa-0b470000759c\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. 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id=\"docs-internal-guid-fb65287a-7fff-1f27-32fa-0b470000759c\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<p><strong>3. 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\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u76ae\u819a\u8001\u5316<\/strong><\/p>\n\n\n\n<p>\u76ae\u819a\u306f\u5916\u90e8\u74b0\u5883\u306b\u76f4\u63a5\u3055\u3089\u3055\u308c\u308b\u305f\u3081\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u7d44\u7e54\u3067\u3059\u3002\u7d2b\u5916\u7dda\u306f\u6d3b\u6027\u9178\u7d20\u3084\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3092\u4ecb\u3057\u3066\u76ae\u819a\u306b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8272\u7d20\u7d30\u80de\u306e\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u523a\u6fc0\u3068\u89d2\u5316\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u640d\u50b7\u306f\u30b7\u30df\u5f62\u6210\u306b\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u523a\u6fc0\u306f\u30b7\u30ef\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u3082\u76ae\u819a\u8001\u5316\u306e\u8981\u56e0\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001AGEs\uff08\u7cd6\u5316\u6700\u7d42\u7523\u7269\uff09\u306e\u84c4\u7a4d\u304c\u76ae\u819a\u306e\u5f3e\u529b\u6027\u4f4e\u4e0b\u3084\u305f\u308b\u307f\u3092\u5f15\u304d\u8d77\u3053\u3059\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. 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style=\"font-size:20px\"><strong>6. \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u5bff\u547d\u5ef6\u9577<\/strong><\/p>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u5bff\u547d\u304c\u5ef6\u3073\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9178\u7d20\u306e\u4f7f\u7528\u91cf\u306e\u4f4e\u3044\u74b0\u5883\u4e0b\u3067\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u8d77\u3053\u308a\u306b\u304f\u304f\u306a\u308a\u3001\u5bff\u547d\u3082\u5ef6\u3073\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u98df\u4e8b\u3084\u751f\u6d3b\u30b9\u30bf\u30a4\u30eb\u306e\u5de5\u592b\u306b\u3088\u308a\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u5f0a\u5bb3\u3092\u5bfe\u7b56\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7. \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u8001\u5e74\u6027\u75be\u60a3<\/strong><\/h3>\n\n\n\n<p>\u751f\u4f53\u5185\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u8001\u5e74\u6027\u75be\u60a3\u306e\u767a\u75c7\u6a5f\u69cb\u306e\u89e3\u660e\u3068\u4e88\u9632\u306b\u95a2\u3059\u308b\u7814\u7a76\u3082\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u96fb\u5b50\u4f1d\u9054\u7cfb\u8907\u5408\u4f53II\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3067\u3042\u308bSDHC\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304b\u3089\u81ea\u7136\u306a\u72b6\u614b\u3067\u6d3b\u6027\u9178\u7d20\u3092\u904e\u5270\u306b\u7523\u751f\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u8001\u5316\u3084\u8001\u4eba\u6027\u75be\u60a3\u306e\u89e3\u660e\u3068\u4e88\u9632\u3092\u76ee\u6307\u3059\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-fb65287a-7fff-1f27-32fa-0b470000759c\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u907a\u4f1d\u5b50\u5909\u7570\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/39740_m-1024x683.jpg\" alt=\"\n\uff24\uff2e\uff21\uff14\uff13\" class=\"wp-image-10560\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39740_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39740_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39740_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39740_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/39740_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u8a98\u767a\u3057\u3001\u304c\u3093\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u5909\u7570\u306f\u901a\u5e38\u3001DNA\u4fee\u5fa9\u6a5f\u69cb\u306b\u3088\u3063\u3066\u4fee\u6b63\u3055\u308c\u307e\u3059\u304c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u3053\u306e\u4fee\u5fa9\u6a5f\u69cb\u304c\u7834\u7dbb\u3057\u3001\u7d30\u80de\u306e\u7570\u5e38\u5897\u6b96\u3084\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. p53\u907a\u4f1d\u5b50\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>p53\u306f\u300c\u30b2\u30ce\u30e0\u306e\u5b88\u8b77\u8005\u300d\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001DNA\u640d\u50b7\u3092\u691c\u51fa\u3057\u3001\u4fee\u5fa9\u3092\u4fc3\u9032\u3057\u305f\u308a\u3001\u7d30\u80de\u6b7b\uff08\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff09\u3092\u8a98\u5c0e\u3057\u305f\u308a\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5f37\u307e\u308b\u3068\u3001p53\u81ea\u4f53\u304c\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u3001\u305d\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0\u304cp53\u306e\u5909\u7570\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u305d\u308c\u304c\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u6297\u9178\u5316\u7269\u8cea\u306e\u6442\u53d6\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u3048\u308b\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u304c\u3001\u304c\u3093\u4e88\u9632\u306b\u304a\u3044\u3066\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/oxidative-stress\">cancer.gov<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-fb65287a-7fff-1f27-32fa-0b470000759c\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff08mtDNA\uff09\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u907a\u4f1d\u7269\u8cea\u306e\u4e00\u3064\u3067\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u3092\u62c5\u3046\u91cd\u8981\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u3067\u3059\u304c\u3001\u305d\u306e\u4ee3\u8b1d\u904e\u7a0b\u3067\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u304c\u767a\u751f\u3057\u307e\u3059\u3002\u3053\u306eROS\u304cmtDNA\u3092\u640d\u50b7\u3059\u308b\u3068\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u306e\u52b9\u7387\u304c\u60aa\u5316\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u306e\u8001\u5316\u304c\u52a0\u901f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u52a0\u9f62\u306b\u4f34\u3044mtDNA\u306e\u640d\u50b7\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u6297\u9178\u5316\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3084\u85ac\u5264\u304cmtDNA\u640d\u50b7\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2649-4\">nature.com<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-fb65287a-7fff-1f27-32fa-0b470000759c\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9<\/strong><\/h2>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u306f\u3001DNA\u306e\u5869\u57fa\u914d\u5217\u3092\u5909\u3048\u308b\u3053\u3068\u306a\u304f\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u4ed5\u7d44\u307f\u3067\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001DNA\u30e1\u30c1\u30eb\u5316\u3084\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3001\u30de\u30a4\u30af\u30edRNA\u306e\u767a\u73fe\u5909\u5316\u3092\u901a\u3058\u3066\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. DNA\u30e1\u30c1\u30eb\u5316\u3068\u8001\u5316<\/strong><\/h3>\n\n\n\n<p>DNA\u30e1\u30c1\u30eb\u5316\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u3067\u3059\u304c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5897\u52a0\u3059\u308b\u3068\u7570\u5e38\u306aDNA\u30e1\u30c1\u30eb\u5316\u304c\u751f\u3058\u3001\u8001\u5316\u304c\u52a0\u901f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u55ab\u7159\u3084\u5927\u6c17\u6c5a\u67d3\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u9818\u57df\u306eDNA\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u3092\u5909\u5316\u3055\u305b\u3001\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304cSIRT1\u907a\u4f1d\u5b50\uff08\u9577\u5bff\u907a\u4f1d\u5b50\uff09\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u306e\u8001\u5316\u304c\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.pnas.org\/content\/116\/16\/7789\">pnas.org<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54<\/strong><\/h3>\n\n\n\n<p>\u30d2\u30b9\u30c8\u30f3\u306fDNA\u3092\u5dfb\u304d\u53d6\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u305d\u306e\u5316\u5b66\u4fee\u98fe\uff08\u30a2\u30bb\u30c1\u30eb\u5316\u3001\u30e1\u30c1\u30eb\u5316\u306a\u3069\uff09\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u306e\u30d1\u30bf\u30fc\u30f3\u3092\u5909\u5316\u3055\u305b\u3001\u6297\u9178\u5316\u5fdc\u7b54\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001Nrf2\uff08Nuclear factor erythroid 2-related factor 2\uff09\u3068\u3044\u3046\u8ee2\u5199\u56e0\u5b50\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u6297\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u307e\u3059\u304c\u3001\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u306e\u5909\u5316\u306b\u3088\u3063\u3066Nrf2\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u7d30\u80de\u306e\u6297\u9178\u5316\u80fd\u529b\u304c\u4f4e\u4e0b\u3057\u3001\u8001\u5316\u304c\u52a0\u901f\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584915000575\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u6804\u990a<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/25476853_m-1024x683.jpg\" alt=\"\n\u30ab\u30e9\u30d5\u30eb\u306a\u30df\u30cb\u30c8\u30de\u30c8\" class=\"wp-image-10567\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25476853_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25476853_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25476853_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25476853_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/25476853_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u98df\u4e8b\u3084\u6804\u990a\u7d20\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3064\u98df\u54c1\u3084\u6804\u990a\u7d20\u3092\u9069\u5207\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306f\u5f37\u529b\u306a\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3061\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u7d30\u80de\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u8d64\u30ef\u30a4\u30f3\u3084\u30d6\u30c9\u30a6\u306b\u542b\u307e\u308c\u308b\u6210\u5206\uff09\u306f\u3001SIRT1\u3092\u6d3b\u6027\u5316\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u3092\u9045\u3089\u305b\u308b\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u7dd1\u8336\u306b\u542b\u307e\u308c\u308b\u30ab\u30c6\u30ad\u30f3\u3084\u3001\u30c0\u30fc\u30af\u30c1\u30e7\u30b3\u30ec\u30fc\u30c8\u306b\u542b\u307e\u308c\u308b\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3082\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u5236\u3059\u308b\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u98df\u54c1\u3092\u65e5\u5e38\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u304b\u3089\u7d30\u80de\u3092\u4fdd\u8b77\u3057\u3001\u8001\u5316\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/academic.oup.com\/nutrition\/article\/34\/9\/1197\/5040035\">nutrition.org<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30d3\u30bf\u30df\u30f3\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3C\u3001\u30d3\u30bf\u30df\u30f3E\u3001\u30d3\u30bf\u30df\u30f3A\uff08\u30d9\u30fc\u30bf\u30ab\u30ed\u30c6\u30f3\uff09\u306f\u3001\u4ee3\u8868\u7684\u306a\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308a\u3001\u7d30\u80de\u819c\u3084DNA\u3092\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u304b\u3089\u5b88\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3C<\/strong>\uff08\u67d1\u6a58\u985e\u3001\u30a4\u30c1\u30b4\u3001\u30d4\u30fc\u30de\u30f3\u306a\u3069\uff09\u306f\u3001\u6c34\u6eb6\u6027\u6297\u9178\u5316\u7269\u8cea\u3068\u3057\u3066\u3001\u8840\u6db2\u4e2d\u306e\u6d3b\u6027\u9178\u7d20\u3092\u7121\u5bb3\u5316\u3059\u308b\u50cd\u304d\u3092\u6301\u3061\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3E<\/strong>\uff08\u30ca\u30c3\u30c4\u985e\u3001\u30a2\u30dc\u30ab\u30c9\u3001\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306a\u3069\uff09\u306f\u3001\u8102\u6eb6\u6027\u6297\u9178\u5316\u7269\u8cea\u3068\u3057\u3066\u7d30\u80de\u819c\u3092\u4fdd\u8b77\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3A\uff08\u30d9\u30fc\u30bf\u30ab\u30ed\u30c6\u30f3\uff09<\/strong>\uff08\u30cb\u30f3\u30b8\u30f3\u3001\u304b\u307c\u3061\u3083\u3001\u307b\u3046\u308c\u3093\u8349\u306a\u3069\uff09\u306f\u3001\u76ae\u819a\u3084\u7c98\u819c\u306e\u4fdd\u8b77\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6804\u990a\u7d20\u3092\u30d0\u30e9\u30f3\u30b9\u3088\u304f\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u6291\u3048\u3001\u5065\u5eb7\u7684\u306a\u8001\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u7d30\u80de\u4fee\u5fa9\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/h2>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u640d\u50b7\u3092\u53d7\u3051\u305f\u7d30\u80de\u306f\u3001\u81ea\u5df1\u4fee\u5fa9\u6a5f\u69cb\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u30c0\u30e1\u30fc\u30b8\u3092\u4fee\u5fa9\u3057\u3088\u3046\u3068\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u306fDNA\u4fee\u5fa9\u6a5f\u69cb\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08\u81ea\u98df\u4f5c\u7528\uff09\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u7d30\u80de\u6b7b\uff09\u306e3\u3064\u306e\u4e3b\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. DNA\u4fee\u5fa9\u6a5f\u69cb\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>DNA\u4fee\u5fa9\u6a5f\u69cb\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u767a\u751f\u3057\u305fDNA\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u305f\u3081\u306b\u50cd\u304d\u307e\u3059\u3002\u4e3b\u306aDNA\u4fee\u5fa9\u6a5f\u69cb\u306b\u306f\u3001\u5869\u57fa\u9664\u53bb\u4fee\u5fa9\uff08BER\uff09\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u9664\u53bb\u4fee\u5fa9\uff08NER\uff09\u3001\u30df\u30b9\u30de\u30c3\u30c1\u4fee\u5fa9\uff08MMR\uff09\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 \u5869\u57fa\u9664\u53bb\u4fee\u5fa9\uff08BER\uff09<br><\/strong> \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u640d\u50b7\u3092\u53d7\u3051\u305fDNA\u5869\u57fa\uff088-\u30aa\u30ad\u30bd\u30b0\u30a2\u30cb\u30f3\u306a\u3069\uff09\u306f\u3001BER\u6a5f\u69cb\u306b\u3088\u3063\u3066\u4fee\u5fa9\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001OGG1\uff088-\u30aa\u30ad\u30bd\u30b0\u30a2\u30cb\u30f3DNA\u30b0\u30ea\u30b3\u30b7\u30e9\u30fc\u30bc\uff09\u306a\u3069\u306e\u4fee\u5fa9\u9175\u7d20\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001OGG1\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u7a81\u7136\u5909\u7570\u306e\u84c4\u7a4d\u304c\u9032\u307f\u3001\u304c\u3093\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5642568\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<p><strong>\u2461 \u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u9664\u53bb\u4fee\u5fa9\uff08NER\uff09<\/strong><strong><br><\/strong> NER\u306f\u3001\u7d2b\u5916\u7dda\u3084\u5316\u5b66\u7269\u8cea\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308bDNA\u306e\u5927\u304d\u306a\u640d\u50b7\u3092\u4fee\u5fa9\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002XPA\u3001XPB\u3001XPC\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u304c\u3042\u308b\u3068\u3001\u76ae\u819a\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2462 \u30df\u30b9\u30de\u30c3\u30c1\u4fee\u5fa9\uff08MMR\uff09<\/strong><strong><br><\/strong> MMR\u306f\u3001DNA\u8907\u88fd\u6642\u306e\u30a8\u30e9\u30fc\u3092\u4fee\u6b63\u3059\u308b\u6a5f\u69cb\u3067\u3042\u308a\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u7a81\u7136\u5909\u7570\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3082\u6301\u3061\u307e\u3059\u3002MLH1\u3084MSH2\u3068\u3044\u3063\u305f\u907a\u4f1d\u5b50\u304c\u3053\u306e\u6a5f\u69cb\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306f\u907a\u4f1d\u6027\u5927\u8178\u304c\u3093\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/30097146_m-1024x683.jpg\" alt=\"\n\u5065\u5eb7\u98df\u6750\" class=\"wp-image-10574\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30097146_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30097146_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30097146_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30097146_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/30097146_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08\u81ea\u98df\u4f5c\u7528\uff09\u306f\u3001\u7d30\u80de\u5185\u306e\u640d\u50b7\u3057\u305f\u30aa\u30eb\u30ac\u30cd\u30e9\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u30fb\u518d\u5229\u7528\u3059\u308b\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308a\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u30c0\u30e1\u30fc\u30b8\u304b\u3089\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 \u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u95a2\u9023\u907a\u4f1d\u5b50\uff08ATG\uff09<\/strong><strong><br><\/strong> \u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001ATG5\u3001ATG7\u3001LC3\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001ATG7\u907a\u4f1d\u5b50\u304c\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u5909\u6027\u304c\u9032\u884c\u3057\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(17)30234-6\">cell.com<\/a>)<\/p>\n\n\n\n<p><strong>\u2461 mTOR\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3068\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc<\/strong><strong><br><\/strong> mTOR\uff08\u54fa\u4e73\u985e\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u30b7\u30b0\u30ca\u30eb\u306f\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6291\u5236\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u9ad8\u307e\u308b\u3068\u3001mTOR\u304c\u6291\u5236\u3055\u308c\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u3067\u7d30\u80de\u306e\u30c0\u30e1\u30fc\u30b8\u4fee\u5fa9\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002\u9006\u306b\u3001\u9ad8\u8102\u80aa\u98df\u306a\u3069\u3067mTOR\u306e\u6d3b\u6027\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u6291\u5236\u3055\u308c\u3001\u7d30\u80de\u8001\u5316\u304c\u9032\u884c\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-fb65287a-7fff-1f27-32fa-0b470000759c\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u640d\u50b7\u304c\u4fee\u5fa9\u4e0d\u80fd\u306a\u7d30\u80de\u3092\u9069\u5207\u306b\u6392\u9664\u3059\u308b\u4ed5\u7d44\u307f\u3067\u3042\u308a\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 Bcl-2\u30d5\u30a1\u30df\u30ea\u30fc\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong> \u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u3068\u3057\u3066\u3001Bcl-2\u30d5\u30a1\u30df\u30ea\u30fc\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002Bcl-2\u306f\u6297\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001Bax\u3084Bak\u306f\u30d7\u30ed\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u907a\u4f1d\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5897\u52a0\u3059\u308b\u3068\u3001Bax\/Bak\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u7d30\u80de\u6b7b\u304c\u8a98\u5c0e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2461 p53\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9<\/strong><strong><br><\/strong> p53\u306f\u3001DNA\u640d\u50b7\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u7d30\u80de\u306e\u7570\u5e38\u3092\u611f\u77e5\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002p53\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u640d\u50b7\u7d30\u80de\u304c\u9069\u5207\u306b\u6392\u9664\u3055\u308c\u305a\u3001\u304c\u3093\u5316\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u5bfe\u7b56\u3068\u3057\u3066\u306e\u751f\u6d3b\u7fd2\u6163<\/strong><\/h2>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u6291\u3048\u308b\u305f\u3081\u306b\u306f\u3001\u9069\u5207\u306a\u751f\u6d3b\u7fd2\u6163\u304c\u91cd\u8981\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u65b9\u6cd5\u304c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b\u306b\u5f79\u7acb\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u98df\u4e8b\u306b\u3088\u308b\u6297\u9178\u5316\u5bfe\u7b56<\/strong><\/h3>\n\n\n\n<p>\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3064\u6804\u990a\u7d20\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u8efd\u6e1b\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d3\u30bf\u30df\u30f3C<\/strong>\uff08\u67d1\u6a58\u985e\u3001\u30ad\u30a6\u30a4\u3001\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\uff09<\/li>\n\n\n\n<li><strong>\u30d3\u30bf\u30df\u30f3E<\/strong>\uff08\u30a2\u30fc\u30e2\u30f3\u30c9\u3001\u30d2\u30de\u30ef\u30ea\u306e\u7a2e\u3001\u30a2\u30dc\u30ab\u30c9\uff09<\/li>\n\n\n\n<li><strong>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb<\/strong>\uff08\u8d64\u30ef\u30a4\u30f3\u3001\u30ab\u30ab\u30aa\u3001\u7dd1\u8336\uff09<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178<\/strong>\uff08\u30b5\u30fc\u30e2\u30f3\u3001\u4e9c\u9ebb\u4ec1\u6cb9\u3001\u30af\u30eb\u30df\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6804\u990a\u7d20\u306f\u3001\u6d3b\u6027\u9178\u7d20\u306e\u4e2d\u548c\u3084DNA\u4fee\u5fa9\u306e\u4fc3\u9032\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.nutrition.org\/publications\/nutrition-research\/\">nutrition.org<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u904b\u52d5\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>\u9069\u5ea6\u306a\u904b\u52d5\u306f\u3001\u6297\u9178\u5316\u9175\u7d20\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3092\u6539\u5584\u3059\u308b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5<\/strong>\uff08\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3001\u30b8\u30e7\u30ae\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\uff09<\/li>\n\n\n\n<li><strong>\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff08\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u904e\u5ea6\u306a\u904b\u52d5\u306f\u9006\u306b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5897\u52a0\u3055\u305b\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u5f37\u5ea6\u3068\u983b\u5ea6\u3067\u884c\u3046\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sportsmedicine.org\/research\/oxidative-stress-and-exercise\">sportsmedicine.com<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/29475248_m-1024x683.jpg\" alt=\"\n\u76ee\u67c4\u3092\u7791\u3063\u3066\u7791\u60f3\u3059\u308b\u7537\u6027\" class=\"wp-image-10581\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29475248_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29475248_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29475248_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29475248_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/29475248_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u3082\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u539f\u56e0\u3068\u306a\u308b\u305f\u3081\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7791\u60f3\u3084\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u306e\u5b9f\u8df5<\/li>\n\n\n\n<li>\u826f\u8cea\u306a\u7761\u7720\u306e\u78ba\u4fdd<\/li>\n\n\n\n<li>\u793e\u4f1a\u7684\u306a\u3064\u306a\u304c\u308a\u3092\u7dad\u6301<\/li>\n<\/ul>\n\n\n\n<p>\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u3053\u3068\u3067\u3001\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5206\u6ccc\u304c\u6291\u5236\u3055\u308c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.psychologytoday.com\/us\/blog\/mindful-living\/2023\/how-stress-affects-aging\">psychologytoday.com<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u795e\u7d4c\u5909\u6027\u75be\u60a3<\/strong><\/h2>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306b\u7279\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u3068\u9032\u884c\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8133\u306f\u5927\u91cf\u306e\u9178\u7d20\u3092\u6d88\u8cbb\u3059\u308b\u305f\u3081\u3001\u6d3b\u6027\u9178\u7d20\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u84c4\u7a4d\u3057\u3084\u3059\u3044\u81d3\u5668\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u306f\u3001\u03b2\u30a2\u30df\u30ed\u30a4\u30c9\uff08A\u03b2\uff09\u306e\u84c4\u7a4d\u3068\u795e\u7d4c\u7d30\u80de\u306e\u5909\u6027\u306b\u3088\u3063\u3066\u7279\u5fb4\u3065\u3051\u3089\u308c\u308b\u75be\u60a3\u3067\u3059\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304cA\u03b2\u306e\u84c4\u7a4d\u3092\u4fc3\u9032\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u6a5f\u80fd\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 Nrf2\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54<\/strong><strong><br><\/strong> Nrf2\uff08Nuclear factor erythroid 2-related factor 2\uff09\u306f\u3001\u6297\u9178\u5316\u5fdc\u7b54\u3092\u5236\u5fa1\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u7d30\u80de\u306e\u9632\u5fa1\u6a5f\u69cb\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u60a3\u8005\u3067\u306fNrf2\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3066\u304a\u308a\u3001\u6297\u9178\u5316\u9175\u7d20\u306e\u767a\u73fe\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3067\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u304c\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6591147\/\">ncbi.nlm.nih.gov<\/a>)<\/p>\n\n\n\n<p><strong>\u2461 \u30d3\u30bf\u30df\u30f3E\u3068\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528<\/strong><strong><br><\/strong> \u30d3\u30bf\u30df\u30f3E\u3084\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306a\u3069\u306e\u6297\u9178\u5316\u7269\u8cea\u306f\u3001\u795e\u7d4c\u7d30\u80de\u3092\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u4fdd\u8b77\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u7dd1\u8336\u306b\u542b\u307e\u308c\u308b\u30ab\u30c6\u30ad\u30f3\u306f\u3001A\u03b2\u306e\u51dd\u96c6\u3092\u6291\u5236\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u751f\u5b58\u7387\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd<\/strong><\/h3>\n\n\n\n<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\uff08PD\uff09\u306f\u3001\u9ed2\u8cea\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u795e\u7d4c\u7d30\u80de\u306e\u5909\u6027\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u75c7\u306b\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 PINK1\u3068\u30d1\u30fc\u30ad\u30f3\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong> PINK1\uff08PTEN-induced kinase 1\uff09\u3068Parkin\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u54c1\u8cea\u7ba1\u7406\u3092\u62c5\u3046\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u640d\u50b7\u3092\u611f\u77e5\u3057\u3001\u7570\u5e38\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u9664\u53bb\u3059\u308b\u5f79\u5272\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u60a3\u8005\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30c0\u30e1\u30fc\u30b8\u304c\u84c4\u7a4d\u3057\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.nature.com\/articles\/s41586-021-03827-9\">nature.com<\/a>)<\/p>\n\n\n\n<p><strong>\u2461 CoQ10\uff08\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\uff09\u306b\u3088\u308b\u6cbb\u7642\u6226\u7565<\/strong><strong><br><\/strong> CoQ10\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u96fb\u5b50\u4f1d\u9054\u7cfb\u3067\u50cd\u304f\u91cd\u8981\u306a\u88dc\u9175\u7d20\u3067\u3042\u308a\u3001\u5f37\u529b\u306a\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3057\u3066\u3001CoQ10\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u81e8\u5e8a\u7814\u7a76\u3067\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u304c\u3093<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/03\/32172955_m-1024x585.jpg\" alt=\"\n\u75c5\u9662\u306b\u5165\u9662\u3059\u308b\u30b7\u30cb\u30a2\u7537\u6027\" class=\"wp-image-10588\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32172955_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32172955_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32172955_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32172955_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/03\/32172955_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u304c\u3093\u306e\u767a\u751f\u306b\u304a\u3044\u3066\u4e8c\u9762\u6027\u3092\u6301\u3064\u8981\u56e0\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u306fDNA\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3057\u767a\u304c\u3093\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u4e00\u65b9\u3067\u3001\u304c\u3093\u7d30\u80de\u304c\u751f\u5b58\u3059\u308b\u305f\u3081\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u6d3b\u6027\u9178\u7d20\u3068\u767a\u304c\u3093<\/strong><\/h3>\n\n\n\n<p>\u6d3b\u6027\u9178\u7d20\uff08ROS\uff09\u306fDNA\u640d\u50b7\u3092\u8a98\u767a\u3057\u3001\u7a81\u7136\u5909\u7570\u306e\u84c4\u7a4d\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u7279\u306b\u3001\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\uff08p53\u306a\u3069\uff09\u304cROS\u306b\u3088\u308b\u640d\u50b7\u3092\u53d7\u3051\u308b\u3068\u3001\u7d30\u80de\u306e\u5897\u6b96\u5236\u5fa1\u304c\u5931\u308f\u308c\u3001\u304c\u3093\u5316\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 p53\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><strong><br><\/strong> p53\u306f\u7d30\u80de\u5468\u671f\u3092\u5236\u5fa1\u3057\u3001DNA\u640d\u50b7\u304c\u4fee\u5fa9\u4e0d\u80fd\u306a\u5834\u5408\u306b\u306f\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001p53\u304c\u5909\u7570\u3059\u308b\u3068\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u6291\u5236\u3067\u304d\u306a\u304f\u306a\u308a\u3001\u60aa\u6027\u5316\u304c\u9032\u884c\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u9ad8\u30ec\u30d9\u30eb\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304cp53\u306e\u5909\u7570\u3092\u8a98\u5c0e\u3057\u3001\u3053\u308c\u304c\u80ba\u304c\u3093\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/cancerres.aacrjournals.org\/content\/75\/15\/3023\">cancerres.aacrjournals.org<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u304c\u3093\u7d30\u80de\u3068\u6297\u9178\u5316\u30b7\u30b0\u30ca\u30eb<\/strong><\/h3>\n\n\n\n<p>\u304c\u3093\u7d30\u80de\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u305f\u3081\u3001Nrf2\u306a\u3069\u306e\u6297\u9178\u5316\u30b7\u30b0\u30ca\u30eb\u3092\u904e\u5270\u306b\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u304c\u3093\u7d30\u80de\u306f\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u3092\u56de\u907f\u3057\u3001\u751f\u5b58\u7387\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 Nrf2\u904e\u5270\u6d3b\u6027\u5316\u3068\u5316\u5b66\u7642\u6cd5\u8010\u6027<\/strong><strong><br><\/strong> \u4e00\u90e8\u306e\u304c\u3093\u3067\u306f\u3001Nrf2\u304c\u7570\u5e38\u306b\u6d3b\u6027\u5316\u3057\u3001\u6297\u9178\u5316\u9175\u7d20\u304c\u904e\u5270\u306b\u7523\u751f\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u5316\u5b66\u7642\u6cd5\u306e\u52b9\u679c\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001Nrf2\u306e\u6291\u5236\u5264\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u7d30\u80de\u306e\u8010\u6027\u3092\u514b\u670d\u3059\u308b\u6cbb\u7642\u6226\u7565\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0304383520300155\">sciencedirect.com<\/a>)<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-fb65287a-7fff-1f27-32fa-0b470000759c\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u514d\u75ab\u6a5f\u80fd<\/strong><\/h2>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002\u9069\u5ea6\u306a\u6d3b\u6027\u9178\u7d20\u306f\u75c5\u539f\u4f53\u3092\u653b\u6483\u3059\u308b\u306e\u306b\u5fc5\u8981\u3067\u3059\u304c\u3001\u904e\u5270\u306a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u514d\u75ab\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. T\u7d30\u80de\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>T\u7d30\u80de\u306f\u514d\u75ab\u5fdc\u7b54\u306e\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u304c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u3001T\u7d30\u80de\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3001\u611f\u67d3\u75c7\u3084\u6162\u6027\u708e\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u52a0\u9f62\u306b\u4f34\u3044\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5897\u52a0\u3059\u308b\u3068\u3001T\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u514d\u75ab\u529b\u306e\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460 \u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3068\u514d\u75ab\u6a5f\u80fd<\/strong><strong><br><\/strong> \u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\uff08GSH\uff09\u306f\u3001\u7d30\u80de\u5185\u306e\u4e3b\u8981\u306a\u6297\u9178\u5316\u7269\u8cea\u3067\u3042\u308a\u3001T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001T\u7d30\u80de\u306e\u5897\u6b96\u304c\u963b\u5bb3\u3055\u308c\u3001\u514d\u75ab\u5fdc\u7b54\u304c\u5f31\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2018.01746\/full\">frontiersin.org<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u30d3\u30bf\u30df\u30f3D\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9<\/strong><\/h3>\n\n\n\n<p>\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u514d\u75ab\u7cfb\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u6297\u9178\u5316\u4f5c\u7528\u3082\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0\u3092\u62db\u304d\u3001\u708e\u75c7\u6027\u75be\u60a3\u3084\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306b\u3088\u3063\u3066\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30de\u30fc\u30ab\u30fc\u304c\u4f4e\u4e0b\u3057\u3001\u514d\u75ab\u6a5f\u80fd\u304c\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2770417\">jamanetwork.com<\/a>)<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p><strong>\u307e\u3068\u3081<\/strong><\/p>\n\n\n\n<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u8001\u5316\u3084\u75be\u60a3\u306e\u4e3b\u8981\u306a\u8981\u56e0\u3067\u3042\u308a\u3001DNA\u640d\u50b7\u3001\u795e\u7d4c\u5909\u6027\u3001\u304c\u3093\u3001\u514d\u75ab\u6a5f\u80fd\u4f4e\u4e0b\u306a\u3069\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002p53\u3084Nrf2\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u5236\u5fa1\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3084\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u7d30\u80de\u4fee\u5fa9\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u6297\u9178\u5316\u6804\u990a\u7d20\uff08\u30d3\u30bf\u30df\u30f3C\u30fbE\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff09\u3084\u9069\u5ea6\u306a\u904b\u52d5\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8efd\u6e1b\u306b\u6709\u52b9\u3067\u3059\u3002\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u3084\u65b0\u305f\u306a\u6297\u9178\u5316\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u8001\u5316\u3084\u95a2\u9023\u75be\u60a3\u306e\u4e3b\u8981\u306a\u8981\u56e0\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306e\u904e\u5270\u306a\u751f\u6210\u306f\u3001DNA\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u8102\u8cea\u306a\u3069\u306e\u7d30\u80de\u6210\u5206\u3092\u640d\u50b7\u3057\u3001\u7d30\u80de\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3084\u7d30\u80de\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u640d\u50b7\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3001\u8001\u5316\u73fe 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