{"id":10967,"date":"2025-04-02T02:55:58","date_gmt":"2025-04-02T02:55:58","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=10967"},"modified":"2025-04-02T04:59:00","modified_gmt":"2025-04-02T04:59:00","slug":"tcf7l2diabetes2","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/tcf7l2diabetes2\/","title":{"rendered":"2\u578b\u7cd6\u5c3f\u75c5\uff08Diabetes Mellitus; Type 2 Diabetes\uff09\u306e\u30ea\u30b9\u30af\u3092\u5de6\u53f3\u3059\u308b\u907a\u4f1d\u5b50\u300eTCF7L2\u300f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32259478_s.jpg\" alt=\"\u306f\u3061\u307f\u3064\" class=\"wp-image-11006\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32259478_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32259478_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>2\u578b\u7cd6\u5c3f\u75c5\uff08Type 2 diabetes; T2D\uff09\u306f\u4e16\u754c\u7684\u306b\u6025\u901f\u306b\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c25\u5e74\u9593\u3067\u60a3\u8005\u6570\u306f\u7d042\u500d\u306e3\u51042500\u4e07\u4eba\u306b\u9054\u3059\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u5897\u52a0\u306e\u4e3b\u306a\u539f\u56e0\u306f\u3001\u98df\u751f\u6d3b\u3084\u8eab\u4f53\u6d3b\u52d5\u306e\u6e1b\u5c11\u3068\u3044\u3063\u305f\u751f\u6d3b\u7fd2\u6163\u306e\u5909\u5316\u304c\u907a\u4f1d\u7684\u8981\u7d20\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u306b\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u3069\u306e\u3088\u3046\u306a\u907a\u4f1d\u7684\u5909\u7570\u304c\u4e00\u8cab\u3057\u3066T2D\u306b\u95a2\u9023\u3059\u308b\u304b\u3092\u7279\u5b9a\u3059\u308b\u306e\u306f\u56f0\u96e3\u3067\u3042\u3063\u305f\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u8ee2\u5199\u56e0\u5b507\u69d82\uff08transcription factor-7\u2013like 2; TCF7L2\uff09\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u4e00\u5869\u57fa\u591a\u578b\uff08Single Nucleotide Polymorphisms; SNPs\uff09\u304c\u3001T2D\u304a\u3088\u3073\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u969c\u5bb3\u3068\u5f37\u304f\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002TCF7L2\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u306e\u6210\u9577\u3084\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308bWnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306b\u95a2\u308f\u308a\u3001\u03b2\u30ab\u30c6\u30cb\u30f3\uff08\u03b2-catenin\uff09\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u3001\u8840\u7cd6\u5024\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u91cd\u8981\u306a\u30db\u30eb\u30e2\u30f3\u524d\u99c6\u4f53\u3067\u3042\u308b\u30d7\u30ed\u30b0\u30eb\u30ab\u30b4\u30f3\uff08proglucagon\uff09\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3059\u308b\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"494\" height=\"333\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/Transcription-factor-7-like-2AF-Q9NQB0-F1.png\" alt=\"Transcription factor 7-like 2\" class=\"wp-image-10976\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/Transcription-factor-7-like-2AF-Q9NQB0-F1.png 494w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/Transcription-factor-7-like-2AF-Q9NQB0-F1-300x202.png 300w\" sizes=\"(max-width: 494px) 100vw, 494px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs7903146-hgtIdeo_genome_38e0de_c9f150-1024x25.png\" alt=\"rs7903146 \" class=\"wp-image-10983\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7903146-hgtIdeo_genome_38e0de_c9f150-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7903146-hgtIdeo_genome_38e0de_c9f150-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7903146-hgtIdeo_genome_38e0de_c9f150-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7903146-hgtIdeo_genome_38e0de_c9f150.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001TCF7L2\u907a\u4f1d\u5b50\u5185\u306e3\u3064\u306eSNP\uff08rs7903146\u3001rs12255372\u3001rs10885406\uff09\u306b\u7279\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u308b\u3002SNP\u3068\u306f\u3001DNA\u306e\u7279\u5b9a\u306e\u4f4d\u7f6e\u306b\u304a\u3051\u308b1\u3064\u306e\u5869\u57fa\u306e\u9055\u3044\u3092\u6307\u3059\u4e00\u822c\u7684\u306a\u907a\u4f1d\u7684\u5909\u7570\u3067\u3042\u308b\u3002\u305d\u306e\u4e2d\u3067rs7903146\u3068rs12255372\u306f\u5f37\u3044\u9023\u9396\u4e0d\u5e73\u8861\uff08linkage disequilibrium; D\u2032 = 0.86\uff09\u3092\u793a\u3057\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u5171\u306b\u907a\u4f1d\u3055\u308c\u3084\u3059\u3044\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3002\u5b9f\u969b\u306bT2D\u3092\u767a\u75c7\u3057\u305f\u4eba\u3067\u306f\u3001rs7903146\u304a\u3088\u3073rs12255372\u306eT\u30a2\u30ec\u30eb\uff08T allele\uff09\u306e\u983b\u5ea6\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\u3002\u307e\u305f\u3001rs10885406\u3068rs7903146\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u89e3\u6790\u3059\u308b\u3068\u3001HapA\u3001HapAB\u3001HapB\u3068\u547c\u3070\u308c\u308b\u7570\u306a\u308b\u907a\u4f1d\u5b50\u578b\u306e\u30b0\u30eb\u30fc\u30d7\uff08haplotypes\uff09\u304c\u5f62\u6210\u3055\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u306f\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3001\u7cd6\u4ee3\u8b1d\u306a\u3069\u306e\u4ee3\u8b1d\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"751\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo10-MfWJbAGNbIDBSDYCOYAAAIJN.png\" alt=\"chromo10\" class=\"wp-image-10990\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo10-MfWJbAGNbIDBSDYCOYAAAIJN.png 751w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo10-MfWJbAGNbIDBSDYCOYAAAIJN-300x200.png 300w\" sizes=\"(max-width: 751px) 100vw, 751px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods <figure class=\"wp-block-image aligncenter\"><\/figure><\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/29217423_s.jpg\" alt=\"\u70ad\u6c34\u5316\u7269\" class=\"wp-image-11020\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29217423_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29217423_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u306e\u30de\u30eb\u30e1\u4e88\u9632\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08Malm\u00f6 Preventive Project; MPP\u30017,061\u540d\uff09\u3068\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306e\u30dc\u30c8\u30cb\u30a2\u7814\u7a76\uff08Botnia study\u30012,651\u540d\uff09\u3068\u3044\u30462\u3064\u306e\u5927\u898f\u6a21\u306a\u524d\u5411\u304d\u7814\u7a76\u306e\u53c2\u52a0\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u53c2\u52a0\u8005\u306f\u907a\u4f1d\u5b50\u578b\u3092\u89e3\u6790\u3055\u308c\uff08genotyped\uff09\u3001\u6700\u592722\u5e74\u9593\u8ffd\u8de1\u8abf\u67fb\u3055\u308c\u3066\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3092\u78ba\u8a8d\u3057\u305f\u3002\u7dcf\u5408\u7684\u306a\u4ee3\u8b1d\u8a55\u4fa1\u3068\u3057\u3066\u3001\u7d4c\u53e3\u30d6\u30c9\u30a6\u7cd6\u8ca0\u8377\u8a66\u9a13\uff08oral glucose tolerance test; OGTT\uff1a\u7cd6\u6442\u53d6\u5f8c\u306e\u8840\u7cd6\u5fdc\u7b54\u3092\u8a55\u4fa1\u3059\u308b\u691c\u67fb\uff09\u3001\u9759\u8108\u5185\u30d6\u30c9\u30a6\u7cd6\u8ca0\u8377\u8a66\u9a13\uff08intravenous glucose tolerance test; IVGTT\uff1a\u9759\u8108\u5185\u306b\u7cd6\u3092\u6ce8\u5165\u3057\u305f\u969b\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u8840\u7cd6\u306e\u5fdc\u7b54\u3092\u8a55\u4fa1\u3059\u308b\u691c\u67fb\uff09\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u8a55\u4fa1\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u5bfe\u3059\u308b\u4f53\u306e\u53cd\u5fdc\u6027\uff09\u306e\u8a55\u4fa1\u3001\u809d\u7cd6\u7523\u751f\u91cf\uff08\u809d\u81d3\u304c\u7523\u751f\u3059\u308b\u7cd6\u306e\u91cf\uff09\u306e\u8a55\u4fa1\u3092\u884c\u3063\u305f\u3002\u307e\u305f\u3001\u6b7b\u5f8c\u63d0\u4f9b\u8005\u306e\u81b5\u5cf6\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3059\u308b\u7d30\u80de\u7fa4\uff09\u3092\u7cd6\u5c3f\u75c5\u975e\u7f79\u60a3\u800519\u540d\u3068\u7cd6\u5c3f\u75c5\u7f79\u60a3\u80057\u540d\u304b\u3089\u63a1\u53d6\u3057\u3001TCF7L2\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u3092\u89e3\u6790\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u907a\u4f1d\u5b50\u3092\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3059\u308b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\uff08adenoviral vector\uff09\u3092\u7528\u3044\u3066\u3001\u4eba\u306e\u81b5\u5cf6\u3067\u5b9f\u9a13\u7684\u306bTCF7L2\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u3001\u305d\u306e\u5f71\u97ff\u3092\u8abf\u3079\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"878\" height=\"794\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/Figure-5.-Colocalization-of-TCF7L2-expression-with-insulin-in-pancreatic-isletsA\u2013D.-Screenshot-2025-04-02-114608.png\" alt=\"Figure 5. Colocalization of TCF7L2 expression with insulin in pancreatic islets(A\u2013D). \" class=\"wp-image-11027\" style=\"width:326px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/Figure-5.-Colocalization-of-TCF7L2-expression-with-insulin-in-pancreatic-isletsA\u2013D.-Screenshot-2025-04-02-114608.png 878w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/Figure-5.-Colocalization-of-TCF7L2-expression-with-insulin-in-pancreatic-isletsA\u2013D.-Screenshot-2025-04-02-114608-300x271.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/Figure-5.-Colocalization-of-TCF7L2-expression-with-insulin-in-pancreatic-isletsA\u2013D.-Screenshot-2025-04-02-114608-768x695.png 768w\" sizes=\"(max-width: 878px) 100vw, 878px\" \/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1934596\/figure\/F5\/\" data-type=\"link\" data-id=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1934596\/figure\/F5\/\"><sup><strong>\u81b5\u5cf6\u306b\u304a\u3051\u308b TCF7L2 \u767a\u73fe\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5171\u5c40\u5728<\/strong><\/sup><br><\/a><sup>\u30d2\u30c8\u81b5\u5cf6\uff08\u9ec4\u8272\uff09\uff08D\uff09\u306b\u304a\u3051\u308bRhodZin\uff08\u8d64\uff09\uff08B\uff09\u3068TCF7L2\uff08\u7dd1\uff09\uff08C\uff09\u306e\u4e8c\u91cd\u67d3\u8272<\/sup><\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>SNP rs7903146\u306eT\u30a2\u30ec\u30eb\u4fdd\u6709\u8005\u306f\u3001\u4e21\u7814\u7a76\u3068\u3082T2D\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\uff08MPP\u3067\u306e\u30aa\u30c3\u30ba\u6bd4\uff08Odds Ratio; OR\uff09=1.58\u3001\u30dc\u30c8\u30cb\u30a2\u7814\u7a76\u3067\u306eOR=1.61\uff09\u3002\u3053\u308c\u306f\u975e\u4fdd\u6709\u8005\u3068\u6bd4\u8f03\u3057\u3066\u7d0460%\u9ad8\u3044\u30ea\u30b9\u30af\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3053\u306eT\u30a2\u30ec\u30eb\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u306e\u4f4e\u4e0b\u3001\u30a4\u30f3\u30b9\u30ea\u30ce\u30b8\u30a7\u30cb\u30c3\u30af\u30a4\u30f3\u30c7\u30c3\u30af\u30b9\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u80fd\u529b\u3092\u793a\u3059\u6307\u6a19\uff09\u306e\u4f4e\u4e0b\u3001\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u4f5c\u7528\uff08\u8178\u7ba1\u30db\u30eb\u30e2\u30f3\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u4f5c\u7528\uff09\u306e\u6e1b\u5f31\u3001\u809d\u7cd6\u7523\u751f\u91cf\u306e\u5897\u52a0\uff08\u809d\u81d3\u306b\u3088\u308b\u7cd6\u7523\u751f\u91cf\u306e\u4e0a\u6607\uff09\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3055\u3089\u306b\u3001\u7d4c\u53e3\u7cd6\u8ca0\u8377\u8a66\u9a13\uff08OGTT\uff09\u304a\u3088\u3073\u30a2\u30eb\u30ae\u30cb\u30f3\u523a\u6fc0\u8a66\u9a13\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u8a55\u4fa1\u6cd5\u306e\u4e00\u3064\uff09\u306b\u304a\u3051\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u91cf\u306f\u3001\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u578b\u4fdd\u6709\u8005\u3067\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3002\u307e\u305f\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u81b5\u5cf6\u3067\u306f\u3001TCF7L2\u306e\u767a\u73fe\u304c\u975e\u7cd6\u5c3f\u75c5\u8005\u306b\u6bd4\u30795\u500d\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u7279\u306bTT\u907a\u4f1d\u5b50\u578b\uff08T\u30a2\u30ec\u30eb\u30922\u3064\u4fdd\u6709\u3059\u308b\u578b\uff09\u306e\u4fdd\u6709\u8005\u3067\u9855\u8457\u3060\u3063\u305f\u3002\u5b9f\u9a13\u7684\u306bTCF7L2\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u3001\u30d2\u30c8\u81b5\u5cf6\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u540c\u69d8\u306b\u4f4e\u4e0b\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/25860874_s.jpg\" alt=\"\u3042\u3081\u3061\u3083\u3093\u306f\u98df\u3079\u306a\u304f\u3066\u3082\u898b\u308b\u3060\u3051\u3067\u3044\u3044\" class=\"wp-image-11050\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25860874_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25860874_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001TCF7L2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3001\u7279\u306bSNP rs7903146\u306f\u3001\u4e3b\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u306e\u969c\u5bb3\u3092\u901a\u3058\u3066T2D\u306e\u30ea\u30b9\u30af\u3092\u5f37\u529b\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002\u3053\u306e\u969c\u5bb3\u306f\u8178\u81b5\u8ef8\uff08enteroinsular axis; \u8178\u3068\u81b5\u81d3\u9593\u306e\u60c5\u5831\u4f1d\u9054\u7d4c\u8def\uff09\u306e\u4e71\u308c\u3084\u3001\u7279\u306bGIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u30da\u30d7\u30c1\u30c9\uff09\u306e\u4f5c\u7528\u5909\u5316\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u809d\u7cd6\u7523\u751f\u91cf\u306e\u5897\u52a0\u3082\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u578b\u4fdd\u6709\u8005\u306e\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u8981\u56e0\u3067\u3042\u308b\u3002\u81b5\u5cf6\u306b\u304a\u3051\u308bTCF7L2\u306e\u904e\u5270\u767a\u73fe\u304c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4f4e\u4e0b\u3092\u76f4\u63a5\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002\u4eca\u56de\u306e\u7d50\u679c\u306f\u3001TCF7L2\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u306e\u4f4e\u4e0b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u4ee3\u511f\u7684\u306b\u5897\u52a0\u3055\u305b\u308b\u8907\u96d1\u306a\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32252259_s.jpg\" alt=\"\u7cd6\u8cea\u5236\u9650\u3057\u3066\u3082\u7f8e\u5473\u3057\u3044\u3082\u306e\u304c\u3042\u308a\u307e\u3059\" class=\"wp-image-11057\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32252259_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32252259_s-300x169.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>TCF7L2\u306e\u907a\u4f1d\u7684\u5909\u7570\u3001\u7279\u306bSNP rs7903146\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u969c\u5bb3\u3001\u8178\u81b5\u8ef8\u306e\u4e71\u308c\u3001\u809d\u7cd6\u7523\u751f\u306e\u5897\u52a0\u306a\u3069\u3092\u901a\u3058\u3066T2D\u767a\u75c7\u3092\u5f37\u529b\u306b\u4e88\u6e2c\u3059\u308b\u3002\u81b5\u5cf6\u306b\u304a\u3051\u308bTCF7L2\u306e\u767a\u73fe\u5897\u52a0\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u969c\u5bb3\u306b\u76f4\u63a5\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u672c\u907a\u4f1d\u5b50\u304c\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u65b0\u305f\u306a\u6a19\u7684\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>2\u578b\u7cd6\u5c3f\u75c5, Type 2 diabetes (T2D), TCF7L2\u907a\u4f1d\u5b50, TCF7L2 gene, \u4e00\u5869\u57fa\u591a\u578b, Single Nucleotide Polymorphisms (SNPs), \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc, insulin secretion, \u8178\u81b5\u8ef8, enteroinsular axis, \u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u4f5c\u7528, incretin effect, \u809d\u7cd6\u7523\u751f, hepatic glucose production, \u81b5\u5cf6, pancreatic islets, \u907a\u4f1d\u7684\u30ea\u30b9\u30af, genetic risk, \u03b2\u7d30\u80de\u6a5f\u80fd, \u03b2-cell function<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1172\/JCI30706\">Lyssenko, V., Lupi, R., Marchetti, P., Del Guerra, S., Orho-Melander, M., Almgren, P., Sj\u00f6gren, M., Ling, C., Eriksson, K. F., Lethagen, A. L., Mancarella, R., Berglund, G., Tuomi, T., Nilsson, P., Del Prato, S., &amp; Groop, L. (2007). Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.&nbsp;The Journal of clinical investigation,&nbsp;117(8), 2155\u20132163. https:\/\/doi.org\/10.1172\/JCI30706<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco&nbsp;Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). 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