{"id":11093,"date":"2025-04-02T04:48:49","date_gmt":"2025-04-02T04:48:49","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=11093"},"modified":"2025-04-04T08:53:06","modified_gmt":"2025-04-04T08:53:06","slug":"asdasp","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/asdasp\/","title":{"rendered":"\u81ea\u9589\u75c7\u306f\u907a\u4f1d\u5b50\u3067\u6c7a\u307e\u308b\uff1f\u77e5\u3063\u3066\u304a\u304d\u305f\u3044ASD\u3068\u907a\u4f1d\u306e\u6df1\u3044\u95a2\u4fc2"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3702632_s.jpg\" alt=\"ASD\" class=\"wp-image-11256\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3702632_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3702632_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3\uff08Autism Spectrum Disorders; ASDs\uff09\u306f\u3001\u793e\u4f1a\u7684\u76f8\u4e92\u4f5c\u7528\u3084\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306b\u56f0\u96e3\u3092\u4f34\u3044\u3001\u7e70\u308a\u8fd4\u3057\u306e\u884c\u52d5\u3084\u3053\u3060\u308f\u308a\u884c\u52d5\u304c\u7279\u5fb4\u306e\u8907\u96d1\u306a\u795e\u7d4c\u767a\u9054\u969c\u5bb3\u3067\u3042\u308b\u3002\u300c\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u300d\u3068\u3044\u3046\u7528\u8a9e\u306f\u3001\u81ea\u9589\u75c7\u3068\u8a3a\u65ad\u3055\u308c\u308b\u4eba\u3005\u304c\u62b1\u3048\u308b\u8ab2\u984c\u3084\u5f37\u307f\u306b\u5e45\u5e83\u3044\u500b\u4eba\u5dee\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u907a\u4f1d\u7684\u8981\u56e0\u304cASD\u306e\u767a\u75c7\u306b\u5927\u304d\u304f\u95a2\u4e0e\u3059\u308b\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308b\u304c\u3001\u7279\u5b9a\u306e\u5171\u901a\u3059\u308b\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u7279\u5b9a\u306f\u3001\u591a\u304f\u306e\u7570\u306a\u308b\u907a\u4f1d\u5b50\u5909\u7570\u304c\u305d\u308c\u305e\u308c\u6bd4\u8f03\u7684\u5c0f\u3055\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u305f\u3081\u306b\u96e3\u3057\u3044\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<p>\u81ea\u9589\u75c7\u306e\u907a\u4f1d\u5b66\u7814\u7a76\u3067\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3068\u4e00\u5869\u57fa\u591a\u578b\uff08Single Nucleotide Polymorphism; SNP\uff09\u304c\u7279\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002SNP\u3068\u306f\u3001DNA\u914d\u5217\u306e\u4e00\u90e8\u304c1\u3064\u306e\u5869\u57fa\u3060\u3051\u5909\u5316\u3057\u305f\u4e00\u822c\u7684\u306a\u907a\u4f1d\u7684\u591a\u69d8\u6027\u306e\u3053\u3068\u3067\u3042\u308b\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs4307059-hgtIdeo_genome_37adb8_cbbfb0-1024x25.png\" alt=\"rs4307059\" class=\"wp-image-11135\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs4307059-hgtIdeo_genome_37adb8_cbbfb0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs4307059-hgtIdeo_genome_37adb8_cbbfb0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs4307059-hgtIdeo_genome_37adb8_cbbfb0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs4307059-hgtIdeo_genome_37adb8_cbbfb0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u67d3\u8272\u4f535p14.1\uff1a\u795e\u7d4c\u7d30\u80de\u9593\u306e\u63a5\u7740\uff08\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u76f8\u4e92\u306b\u63a5\u7d9a\u3057\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u3092\u53d6\u308b\u30d7\u30ed\u30bb\u30b9\uff09\u306b\u95a2\u4e0e\u3059\u308b\u30ab\u30c9\u30d8\u30ea\u30f3\uff08cadherin\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308bCDH9\u304a\u3088\u3073CDH10\u907a\u4f1d\u5b50\u9593\u306b\u4f4d\u7f6e\u3059\u308bSNP\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u7279\u306b\u91cd\u8981\u306aSNP\u306frs4307059\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"948\" height=\"535\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9Y6N8-F1-1.png\" alt=\"Cadherin-10\" class=\"wp-image-11150\" style=\"width:634px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9Y6N8-F1-1.png 948w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9Y6N8-F1-1-300x169.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9Y6N8-F1-1-768x433.png 768w\" sizes=\"(max-width: 948px) 100vw, 948px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs2518352-hgtIdeo_genome_25f84a_cbdbb0-1024x25.png\" alt=\"rs2518352\" class=\"wp-image-11164\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2518352-hgtIdeo_genome_25f84a_cbdbb0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2518352-hgtIdeo_genome_25f84a_cbdbb0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2518352-hgtIdeo_genome_25f84a_cbdbb0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2518352-hgtIdeo_genome_25f84a_cbdbb0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>BH4\uff08\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u30d3\u30aa\u30d7\u30c6\u30ea\u30f3\uff09\u7d4c\u8def\u907a\u4f1d\u5b50\uff1a\u3053\u306e\u751f\u5316\u5b66\u7684\u7d4c\u8def\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3084\u30c9\u30fc\u30d1\u30df\u30f3\u306a\u3069\u8133\u306e\u60c5\u5831\u4f1d\u9054\u306b\u91cd\u8981\u306a\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3092\u5408\u6210\u3059\u308b\u3002PTS\u907a\u4f1d\u5b50\u306eSNP\uff08rs2518352\u3001rs3819331\uff09\u304a\u3088\u3073SPR\u907a\u4f1d\u5b50\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u521d\u671f\u7814\u7a76\u3067\u81ea\u9589\u75c7\u3068\u306e\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"940\" height=\"315\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q03393-F1.png\" alt=\"6-pyruvoyl tetrahydrobiopterin synthase\" class=\"wp-image-11157\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q03393-F1.png 940w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q03393-F1-300x101.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q03393-F1-768x257.png 768w\" sizes=\"(max-width: 940px) 100vw, 940px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs3923890-hgtIdeo_genome_268c35_cbe3b0-1024x25.png\" alt=\"rs3923890\" class=\"wp-image-11178\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs3923890-hgtIdeo_genome_268c35_cbe3b0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs3923890-hgtIdeo_genome_268c35_cbe3b0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs3923890-hgtIdeo_genome_268c35_cbe3b0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs3923890-hgtIdeo_genome_268c35_cbe3b0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>ROBO\u907a\u4f1d\u5b50\u7fa4\uff1aROBO\u907a\u4f1d\u5b50\u306f\u8ef8\u7d22\uff08axon\u3001\u795e\u7d4c\u7d30\u80de\u306e\u9577\u3044\u4f38\u9577\u90e8\u4f4d\uff09\u306e\u8a98\u5c0e\u306b\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308a\u51fa\u3057\u3001\u9069\u5207\u306a\u795e\u7d4c\u56de\u8def\u5f62\u6210\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002ROBO3\u907a\u4f1d\u5b50\uff08\u4f8b\uff1ars3923890\u3001rs7925879\u3001rs4606490\u3001rs3802905\uff09\u304a\u3088\u3073ROBO4\u907a\u4f1d\u5b50\uff08rs6590109\uff09\u306eSNP\u304c\u81ea\u9589\u75c7\u3068\u306e\u95a2\u9023\u3092\u793a\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"695\" height=\"678\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q96MS0-F1.png\" alt=\"Roundabout homolog 3\" class=\"wp-image-11171\" style=\"width:667px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q96MS0-F1.png 695w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q96MS0-F1-300x293.png 300w\" sizes=\"(max-width: 695px) 100vw, 695px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs12537269-hgtIdeo_genome_26ca39_cbe780-1024x25.png\" alt=\"rs12537269\" class=\"wp-image-11185\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs12537269-hgtIdeo_genome_26ca39_cbe780-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs12537269-hgtIdeo_genome_26ca39_cbe780-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs12537269-hgtIdeo_genome_26ca39_cbe780-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs12537269-hgtIdeo_genome_26ca39_cbe780.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>IMMP2L\u304a\u3088\u3073DOCK4\u907a\u4f1d\u5b50\uff08\u67d3\u8272\u4f537q\u4e0a\u306eAUTS1\u907a\u4f1d\u5b50\u5ea7\uff09\uff1aIMMP2L\u907a\u4f1d\u5b50\u306f\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u751f\u7523\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u306b\u3001DOCK4\u907a\u4f1d\u5b50\u306f\u795e\u7d4c\u63a5\u7d9a\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002SNP\u3068\u3057\u3066IMMP2L\u306ers12537269\u304a\u3088\u3073DOCK4\u306ers2217262\u304c\u7279\u5b9a\u3055\u308c\u3001\u3055\u3089\u306b\u30b3\u30d4\u30fc\u6570\u591a\u578b\uff08Copy Number Variation; CNV\uff09\u3068\u3044\u3046\u69cb\u9020\u7684\u907a\u4f1d\u5b50\u5909\u7570\u3082\u95a2\u9023\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"535\" height=\"531\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q96T52-F1.png\" alt=\"Mitochondrial inner membrane protease subunit 2\" class=\"wp-image-11192\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q96T52-F1.png 535w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q96T52-F1-300x298.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q96T52-F1-150x150.png 150w\" sizes=\"(max-width: 535px) 100vw, 535px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs6766410-hgtIdeo_genome_3abf07_cbecd0-1024x25.png\" alt=\"rs6766410\" class=\"wp-image-11199\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6766410-hgtIdeo_genome_3abf07_cbecd0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6766410-hgtIdeo_genome_3abf07_cbecd0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6766410-hgtIdeo_genome_3abf07_cbecd0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6766410-hgtIdeo_genome_3abf07_cbecd0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>HTR3C\u907a\u4f1d\u5b50\uff08\u67d3\u8272\u4f533q25-27\uff09\uff1aHTR3C\u306f\u30bb\u30ed\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f53\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3092\u30b3\u30fc\u30c9\u3057\u3001\u795e\u7d4c\u4f1d\u9054\u3084\u6c17\u5206\u8abf\u7bc0\u306b\u91cd\u8981\u3067\u3042\u308b\u3002\u91cd\u8981\u306aSNP\u306frs6766410\uff08N163K\uff09\u304a\u3088\u3073rs6807362\uff08G405A\uff09\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"846\" height=\"560\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q8WXA8-F1.png\" alt=\"5-hydroxytryptamine receptor 3C\" class=\"wp-image-11206\" style=\"width:674px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q8WXA8-F1.png 846w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q8WXA8-F1-300x199.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q8WXA8-F1-768x508.png 768w\" sizes=\"(max-width: 846px) 100vw, 846px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs1322784-hgtIdeo_genome_27fc75_cbf890-1024x25.png\" alt=\"rs1322784\" class=\"wp-image-11213\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1322784-hgtIdeo_genome_27fc75_cbf890-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1322784-hgtIdeo_genome_27fc75_cbf890-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1322784-hgtIdeo_genome_27fc75_cbf890-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1322784-hgtIdeo_genome_27fc75_cbf890.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>DISC1\u907a\u4f1d\u5b50\uff08\u67d3\u8272\u4f531q42\uff09\uff1aDISC1\uff08Disrupted-in-Schizophrenia 1\uff09\u306f\u8133\u306e\u767a\u9054\u306b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u69d8\u3005\u306a\u7cbe\u795e\u75be\u60a3\u3068\u306e\u95a2\u9023\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u7279\u306b\u30a2\u30b9\u30da\u30eb\u30ac\u30fc\u75c7\u5019\u7fa4\u3068\u306e\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u305fSNP\uff08rs1322784\uff09\u3068\u3001\u30de\u30a4\u30af\u30ed\u30b5\u30c6\u30e9\u30a4\u30c8\u30de\u30fc\u30ab\u30fcD1S2709\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"650\" height=\"539\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9NRI5-F1.png\" alt=\"Disrupted in schizophrenia 1 protein\" class=\"wp-image-11220\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9NRI5-F1.png 650w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9NRI5-F1-300x249.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/30307136_s.jpg\" alt=\"\u30e1\u30ac\u30cd\u5973\u6027\" class=\"wp-image-11228\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30307136_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30307136_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u304b\u3089\u3001\u81ea\u9589\u75c7\u306b\u95a2\u3059\u308b\u907a\u4f1d\u8981\u56e0\u306e\u8907\u96d1\u3055\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u7a00\u306a\u907a\u4f1d\u5b50\u5909\u7570\u3068\u5171\u901a\u3059\u308b\u907a\u4f1d\u5b50\u5909\u7570\u306e\u4e21\u65b9\u304c\u81ea\u9589\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u7279\u306b\u795e\u7d4c\u7d30\u80de\u9593\u306e\u63a5\u7740\uff08CDH9\u3001CDH10\u306a\u3069\uff09\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306b\u3088\u308b\u795e\u7d4c\u4f1d\u9054\uff08HTR3C\uff09\u3001\u8ef8\u7d22\u8a98\u5c0e\uff08ROBO\u907a\u4f1d\u5b50\u7fa4\uff09\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u305f\u3002\u307e\u305fDISC1\u907a\u4f1d\u5b50\u304c\u81ea\u9589\u75c7\u3068\u4ed6\u306e\u7cbe\u795e\u75be\u60a3\u3068\u306e\u907a\u4f1d\u7684\u5171\u901a\u6027\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u3088\u308a\u5e83\u3044\u795e\u7d4c\u767a\u9054\u3078\u306e\u5f71\u97ff\u304c\u8003\u3048\u3089\u308c\u308b\u3002\u4e00\u65b9\u3001BH4\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u5408\u6210\u7d4c\u8def\u306e\u907a\u4f1d\u5b50\u306f\u521d\u671f\u7814\u7a76\u3067\u95a2\u9023\u6027\u304c\u793a\u3055\u308c\u305f\u3082\u306e\u306e\u3001\u518d\u73fe\u6027\u306f\u4f4e\u304f\u3001\u81ea\u9589\u75c7\u7814\u7a76\u306e\u8907\u96d1\u6027\u3068\u591a\u69d8\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s.jpg\" alt=\"ASD\" class=\"wp-image-11235\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7814\u7a76\u3067\u7528\u3044\u3089\u308c\u305f\u4e3b\u306a\u65b9\u6cd5\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08Genome-Wide Association Studies; GWAS\uff09\uff1a\u591a\u6570\u306e\u500b\u4eba\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u5206\u6790\u3057\u3001\u75c5\u6c17\u306b\u95a2\u9023\u3059\u308b\u4e00\u822c\u7684\u306a\u907a\u4f1d\u5b50\u5909\u7570\uff08SNP\uff09\u3092\u7279\u5b9a\u3059\u308b\u5927\u898f\u6a21\u306a\u7814\u7a76\u624b\u6cd5\u3002<\/li>\n\n\n\n<li>\u6a19\u7684SNP\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\uff1a\u904e\u53bb\u306e\u7814\u7a76\u3067\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u305f\u7279\u5b9a\u907a\u4f1d\u5b50\u3092\u3001\u5c0f\u898f\u6a21\u306a\u5bb6\u65cf\u30d9\u30fc\u30b9\u306e\u96c6\u56e3\u3067\u8a73\u7d30\u306b\u89e3\u6790\u3059\u308b\u65b9\u6cd5\u3002<\/li>\n\n\n\n<li>\u30b3\u30d4\u30fc\u6570\u591a\u578b\uff08CNV\uff09\u89e3\u6790\uff1a\u907a\u4f1d\u5b50\u306e\u4e00\u90e8\u304c\u91cd\u8907\u307e\u305f\u306f\u6b20\u5931\u3059\u308b\u3088\u3046\u306a\u5927\u898f\u6a21\u306a\u907a\u4f1d\u5b50\u69cb\u9020\u5909\u5316\u3092\u89e3\u6790\u3057\u3001\u75c5\u6c17\u3068\u306e\u95a2\u9023\u3092\u8abf\u3079\u308b\u65b9\u6cd5\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\uff1aRNA\u30ec\u30d9\u30eb\uff08\u907a\u4f1d\u5b50\u306e\u6d3b\u52d5\u72b6\u6cc1\u3092\u793a\u3059\uff09\u3092\u81ea\u9589\u75c7\u7fa4\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3067\u6bd4\u8f03\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u5909\u7570\u304c\u6a5f\u80fd\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b\u624b\u6cd5\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/5034336_s.jpg\" alt=\"ASD\" class=\"wp-image-11242\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/5034336_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/5034336_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u67d3\u8272\u4f535p14.1\u306eSNP rs4307059\u304c\u5168\u30b2\u30ce\u30e0\u30ec\u30d9\u30eb\u3067\u306e\u6709\u610f\u6027\u3092\u793a\u3057\u3001\u81ea\u9589\u75c7\u3068\u306e\u5f37\u3044\u95a2\u9023\u3092\u78ba\u8a8d\uff08P=3.4\u00d710\u207b\u2078\u3001\u30aa\u30c3\u30ba\u6bd4 [OR]=1.19\uff09\u3002\u8907\u6570\u306e\u96c6\u56e3\u3067\u518d\u73fe\u3055\u308c\u305f\u3002<\/li>\n\n\n\n<li>BH4\u7d4c\u8def\u306ePTS\u907a\u4f1d\u5b50SNP\uff08rs2518352 P=0.009; rs3819331 P=0.01\uff09\u306f\u521d\u671f\u306f\u6709\u610f\u3060\u3063\u305f\u304c\u518d\u73fe\u6027\u306b\u4e4f\u3057\u304b\u3063\u305f\u3002<\/li>\n\n\n\n<li>ROBO\u907a\u4f1d\u5b50\u7fa4\u306e\u8907\u6570\u306eSNP\u304c\u81ea\u9589\u75c7\u3068\u95a2\u9023\u3057\u3001\u7279\u306bROBO4\u306eSNP rs6590109\uff08P=0.009\uff09\u304c\u6700\u3082\u5f37\u304b\u3063\u305f\u3002<\/li>\n\n\n\n<li>IMMP2L\uff08rs12537269, P=7.3\u00d710\u207b\u2075\uff09\u304a\u3088\u3073DOCK4\uff08rs2217262, P=9.2\u00d710\u207b\u2074\uff09\u306eSNP\u306fCNV\u89e3\u6790\u3067\u3082\u78ba\u8a8d\u3055\u308c\u3001\u95a2\u9023\u6027\u304c\u9ad8\u304b\u3063\u305f\u3002<\/li>\n\n\n\n<li>HTR3C\u306eSNP\uff08rs6766410\u3001rs6807362; \u4e21\u65b9P=0.0012\uff09\u306f\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u89e3\u6790\u3067\u3055\u3089\u306b\u5f37\u5316\u3055\u308c\u305f\u3002<\/li>\n\n\n\n<li>DISC1\u306eSNP rs1322784\u304c\u30a2\u30b9\u30da\u30eb\u30ac\u30fc\u75c7\u5019\u7fa4\uff08P=0.0058\uff09\u3068\u3001D1S2709\u304c\u81ea\u9589\u75c7\uff08P=0.004\uff09\u3068\u306e\u95a2\u9023\u3092\u793a\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23502599_s-1.jpg\" alt=\"\u304f\u307e\" class=\"wp-image-11249\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23502599_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23502599_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3\u306e\u907a\u4f1d\u7684\u57fa\u76e4\u304c\u975e\u5e38\u306b\u8907\u96d1\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u7279\u5b9a\u3055\u308c\u305f\u907a\u4f1d\u5b50\u7fa4\u306f\u4e3b\u306b\u795e\u7d4c\u56de\u8def\u5f62\u6210\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u63a5\u7d9a\u6027\u3001\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u5408\u6210\u304a\u3088\u3073\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u60c5\u5831\u4f1d\u9054\u7d4c\u8def\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u7279\u306bCDH9\u3001CDH10\u306e\u3088\u3046\u306a\u30cb\u30e5\u30fc\u30ed\u30f3\u9593\u306e\u63a5\u7740\u5206\u5b50\u3084HTR3C\u306b\u3088\u308b\u30bb\u30ed\u30c8\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001ROBO\u907a\u4f1d\u5b50\u7fa4\u306b\u3088\u308b\u8ef8\u7d22\u8a98\u5c0e\u7d4c\u8def\u304c\u81ea\u9589\u75c7\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002\u307e\u305f\u3001DISC1\u907a\u4f1d\u5b50\u306f\u81ea\u9589\u75c7\u3060\u3051\u3067\u306a\u304f\u4ed6\u306e\u7cbe\u795e\u75be\u60a3\u3068\u306e\u907a\u4f1d\u7684\u306a\u95a2\u9023\u6027\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u81ea\u9589\u75c7\u306e\u75c5\u614b\u7406\u89e3\u3092\u3088\u308a\u5e83\u7bc4\u306a\u795e\u7d4c\u767a\u9054\u969c\u5bb3\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u6df1\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u4eca\u5f8c\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u7684\u8981\u56e0\u3092\u3055\u3089\u306b\u8a73\u7d30\u306b\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3088\u308a\u898f\u6a21\u306e\u5927\u304d\u306a\u96c6\u56e3\u3067\u306e\u7814\u7a76\u3084\u3001\u907a\u4f1d\u5b50\u5909\u7570\u306e\u751f\u7269\u5b66\u7684\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u5b9f\u9a13\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u307e\u305f\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u3092\u7db2\u7f85\u3059\u308b\u89e3\u6790\u3068\u7279\u5b9a\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u8a55\u4fa1\u3092\u7d71\u5408\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3001\u81ea\u9589\u75c7\u306e\u4e88\u9632\u3001\u8a3a\u65ad\u3001\u6cbb\u7642\u306e\u65b0\u3057\u3044\u65b9\u6cd5\u3092\u898b\u51fa\u3059\u305f\u3081\u306b\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3\uff08ASD\uff09\u3001\u4e00\u5869\u57fa\u591a\u578b\uff08SNP\uff09\u3001\u907a\u4f1d\u5b66\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u63a5\u7740\u5206\u5b50\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3001\u8ef8\u7d22\u30ac\u30a4\u30c0\u30f3\u30b9\u3001CDH9\u3001CDH10\u3001BH4\u7d4c\u8def\u3001ROBO\u907a\u4f1d\u5b50\u3001IMMP2L\u3001DOCK4\u3001HTR3C\u3001DISC1<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/nature07999\">Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M., Kim, C. E., Hou, C., Frackelton, E., Chiavacci, R., Takahashi, N., Sakurai, T., Rappaport, E., Lajonchere, C. M., Munson, J., Estes, A., \u2026 Hakonarson, H. (2009). Common genetic variants on 5p14.1 associate with autism spectrum disorders.\u00a0<em>Nature<\/em>,\u00a0<em>459<\/em>(7246), 528\u2013533. https:\/\/doi.org\/10.1038\/nature07999<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1111\/j.1601-183X.2009.00521.x\">Schnetz-Boutaud, N. C., Anderson, B. M., Brown, K. D., Wright, H. H., Abramson, R. K., Cuccaro, M. L., Gilbert, J. R., Pericak-Vance, M. A., &amp; Haines, J. L. (2009). Examination of tetrahydrobiopterin pathway genes in autism.\u00a0<em>Genes, brain, and behavior<\/em>,\u00a0<em>8<\/em>(8), 753\u2013757. https:\/\/doi.org\/10.1111\/j.1601-183X.2009.00521.x<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/ajmg.b.30697\">Anitha, A., Nakamura, K., Yamada, K., Suda, S., Thanseem, I., Tsujii, M., Iwayama, Y., Hattori, E., Toyota, T., Miyachi, T., Iwata, Y., Suzuki, K., Matsuzaki, H., Kawai, M., Sekine, Y., Tsuchiya, K., Sugihara, G., Ouchi, Y., Sugiyama, T., Koizumi, K., \u2026 Mori, N. (2008). Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.\u00a0<em>American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics<\/em>,\u00a0<em>147B<\/em>(7), 1019\u20131027. https:\/\/doi.org\/10.1002\/ajmg.b.30697<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/mp.2009.34\">Maestrini, E., Pagnamenta, A. T., Lamb, J. A., Bacchelli, E., Sykes, N. H., Sousa, I., Toma, C., Barnby, G., Butler, H., Winchester, L., Scerri, T. S., Minopoli, F., Reichert, J., Cai, G., Buxbaum, J. D., Korvatska, O., Schellenberg, G. D., Dawson, G., de Bildt, A., Minderaa, R. B., \u2026 IMGSAC (2010). High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.\u00a0<em>Molecular psychiatry<\/em>,\u00a0<em>15<\/em>(9), 954\u2013968. https:\/\/doi.org\/10.1038\/mp.2009.34<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1002\/ajmg.b.30882\">Rehnstr\u00f6m, K., Ylisaukko-oja, T., Nummela, I., Ellonen, P., Kempas, E., Vanhala, R., von Wendt, L., J\u00e4rvel\u00e4, I., &amp; Peltonen, L. (2009). Allelic variants in HTR3C show association with autism.\u00a0<em>American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics<\/em>,\u00a0<em>150B<\/em>(5), 741\u2013746. https:\/\/doi.org\/10.1002\/ajmg.b.30882<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/sj.mp.4002031\">Kilpinen, H., Ylisaukko-Oja, T., Hennah, W., Palo, O. M., Varilo, T., Vanhala, R., Nieminen-von Wendt, T., von Wendt, L., Paunio, T., &amp; Peltonen, L. (2008). Association of DISC1 with autism and Asperger syndrome.\u00a0<em>Molecular psychiatry<\/em>,\u00a0<em>13<\/em>(2), 187\u2013196. https:\/\/doi.org\/10.1038\/sj.mp.4002031<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3\uff08Autism Spectrum Disorders; ASDs\uff09\u306f\u3001\u793e\u4f1a\u7684\u76f8\u4e92\u4f5c\u7528\u3084\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306b\u56f0\u96e3\u3092\u4f34\u3044\u3001\u7e70\u308a\u8fd4\u3057\u306e\u884c\u52d5\u3084\u3053\u3060\u308f\u308a\u884c\u52d5\u304c\u7279\u5fb4\u306e\u8907\u96d1\u306a\u795e\u7d4c\u767a\u9054\u969c [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":11121,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[237],"tags":[248,260,250,247,253,256,261,254,257,242,249,255,252,225,258,246,244,245,251,59,259],"class_list":["post-11093","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-paper","tag-asd","tag-bh4","tag-cdh10","tag-cdh9","tag-disc1","tag-dock4","tag-htr3c","tag-immp2l","tag-robo","tag-snp","tag-249","tag-255","tag-252","tag-225","tag-258","tag-246","tag-244","tag-245","tag-251","tag-59","tag-259"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11093","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=11093"}],"version-history":[{"count":3,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11093\/revisions"}],"predecessor-version":[{"id":11263,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11093\/revisions\/11263"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/11121"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=11093"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=11093"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=11093"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}