{"id":11271,"date":"2025-04-02T05:53:19","date_gmt":"2025-04-02T05:53:19","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=11271"},"modified":"2025-04-04T08:53:05","modified_gmt":"2025-04-04T08:53:05","slug":"tallglassofwater","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/tallglassofwater\/","title":{"rendered":"\u8eab\u9577\u306f\u907a\u4f1d\u3067\u3069\u3053\u307e\u3067\u6c7a\u307e\u308b\uff1f20\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u660e\u3089\u304b\u306b\u3057\u305f\u6210\u9577\u306e\u3057\u304f\u307f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"428\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/25972378_s.jpg\" alt=\"\u30ad\u30ea\u30f3\" class=\"wp-image-11299\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25972378_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25972378_s-300x201.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u6210\u4eba\u8eab\u9577\uff08adult height\uff09\u306f\u4ee3\u8868\u7684\u306a\u591a\u907a\u4f1d\u5b50\u5f62\u8cea\uff08polygenic trait\uff09\u306e\u4e00\u4f8b\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u591a\u6570\u306e\u907a\u4f1d\u5b50\u304c\u5c11\u3057\u305a\u3064\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u307e\u3059\u3002\u8eab\u9577\u306f\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306b\u7406\u60f3\u7684\u306a\u5bfe\u8c61\u3067\u3042\u308a\u3001\u6b63\u78ba\u304b\u3064\u5bb9\u6613\u306b\u6e2c\u5b9a\u53ef\u80fd\u3067\u3001\u96c6\u56e3\u5185\u3067\u89b3\u5bdf\u3055\u308c\u308b\u8eab\u9577\u306e\u3070\u3089\u3064\u304d\u306e\u6700\u592790%\u304c\u907a\u4f1d\u7684\u8981\u7d20\u306b\u3088\u3063\u3066\u8aac\u660e\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u9ad8\u3044\u907a\u4f1d\u7387\uff08heritability\uff09\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u5bb6\u65cf\u5185\u3067\u907a\u4f1d\u5b50\u304c\u5171\u306b\u53d7\u3051\u7d99\u304c\u308c\u308b\u3053\u3068\u3092\u8abf\u3079\u308b\u9023\u9396\u89e3\u6790\uff08linkage study\uff09\u3084\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u8eab\u9577\u306b\u95a2\u9023\u3059\u308b\u3068\u4eee\u8aac\u3092\u7acb\u3066\u3066\u8abf\u3079\u308b\u5019\u88dc\u907a\u4f1d\u5b50\u7814\u7a76\uff08candidate gene study\uff09\u3067\u306f\u3001\u4e00\u822c\u7684\u306a\u8eab\u9577\u306e\u5dee\u3092\u751f\u3080\u5177\u4f53\u7684\u306a\u907a\u4f1d\u5b50\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u306f\u96e3\u822a\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u6700\u8fd1\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08Genome-Wide Association: GWA\uff09\u306b\u3088\u308a\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u306e\u6570\u5341\u4e07\u7b87\u6240\u306b\u304a\u3088\u3076\u907a\u4f1d\u5b50\u5909\u7570\u3092\u540c\u6642\u306b\u8abf\u67fb\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u4eba\u9593\u306e\u6210\u9577\u3068\u767a\u9054\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1968959_s.jpg\" alt=\"\u8eab\u9577\u5dee\" class=\"wp-image-11308\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1968959_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1968959_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u6700\u521d\u306b\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u306e13,665\u4eba\u3092\u5bfe\u8c61\u306b\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWA\uff09\u3092\u5b9f\u65bd\u3057\u3001\u305d\u306e\u5f8c\u3055\u3089\u306b16,482\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c2\u6bb5\u968e\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u6210\u4eba\u306e\u8eab\u9577\u3068\u6709\u610f\u306b\u95a2\u9023\u3059\u308b\uff08\u5076\u7136\u3067\u3042\u308b\u78ba\u7387\u304c\u6975\u3081\u3066\u4f4e\u3044\u3053\u3068\u3092\u793a\u3059P &lt; 5 \u00d7 10\u207b\u2077\uff0920\u306e\u72ec\u7acb\u3057\u305f\u4e00\u5869\u57fa\u591a\u578b\uff08Single Nucleotide Polymorphism: SNP\uff09\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u3046\u306110\u500b\u306eSNP\u306f\u7279\u306b\u5f37\u529b\u306a\u95a2\u9023\uff08P &lt; 1 \u00d7 10\u207b\u00b9\u2070\uff09\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306eSNP\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306f\u3001\u4ee5\u4e0b\u306e\u91cd\u8981\u306a\u751f\u7269\u5b66\u7684\u7d4c\u8def\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30cf\u30ea\u30cd\u30ba\u30df\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\uff08Hedgehog signaling pathway\uff09<\/strong>: \u767a\u751f\u751f\u7269\u5b66\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046\u7d4c\u8def\u3067\u3042\u308a\u3001\u7d30\u80de\u306e\u6210\u9577\u3084\u5206\u5316\u3001\u7d44\u7e54\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\uff08\u95a2\u9023\u907a\u4f1d\u5b50: IHH\uff08Indian hedgehog\uff09, HHIP\uff08hedgehog interacting protein\uff09, PTCH1\uff08patched homolog 1\uff09\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"640\" height=\"572\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31880169_s.jpg\" alt=\"hedgehog\" class=\"wp-image-11316\" style=\"width:430px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31880169_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31880169_s-300x268.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08extracellular matrix\uff09<\/strong>: \u7d30\u80de\u306e\u5916\u5074\u306b\u3042\u308b\u69cb\u9020\u7684\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3067\u3001\u7d44\u7e54\u306e\u7269\u7406\u7684\u5f37\u5ea6\u3084\u7d30\u80de\u9593\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\uff08\u95a2\u9023\u907a\u4f1d\u5b50: EFEMP1, ADAMTSL3, ACAN\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"879\" height=\"617\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q12805-F1.png\" alt=\"EGF-containing fibulin-like extracellular matrix protein 1\" class=\"wp-image-11323\" style=\"width:574px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q12805-F1.png 879w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q12805-F1-300x211.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q12805-F1-768x539.png 768w\" sizes=\"(max-width: 879px) 100vw, 879px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u304c\u3093\u95a2\u9023\u907a\u4f1d\u5b50\uff08cancer-associated genes\uff09<\/strong>: \u7d30\u80de\u5468\u671f\u306e\u8abf\u7bc0\u3084\u7d30\u80de\u306e\u5206\u5316\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u304c\u3093\u3067\u306f\u3057\u3070\u3057\u3070\u7570\u5e38\u304c\u898b\u3089\u308c\u307e\u3059\uff08\u95a2\u9023\u907a\u4f1d\u5b50: CDK6\uff08cyclin-dependent kinase 6\uff09, HMGA2\uff08high-mobility group AT-hook 2\uff09, DLEU7\uff08deleted in lymphocytic leukemia 7\uff09\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"777\" height=\"599\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q00534-F1.png\" alt=\"Cyclin-dependent kinase 6\" class=\"wp-image-11330\" style=\"width:553px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q00534-F1.png 777w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q00534-F1-300x231.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q00534-F1-768x592.png 768w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7279\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305fSNP\u3068\u3057\u3066\u306f\u4ee5\u4e0b\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CDK6\u907a\u4f1d\u5b50\u5185\u306e<strong>rs2282978<\/strong>\uff08CDK6\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5f71\u97ff; P = 1 \u00d7 10\u207b\u2076\uff09<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs2282978-hgtIdeo_genome_367d73_ccd5d0-1024x25.png\" alt=\"rs2282978\" class=\"wp-image-11337\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2282978-hgtIdeo_genome_367d73_ccd5d0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2282978-hgtIdeo_genome_367d73_ccd5d0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2282978-hgtIdeo_genome_367d73_ccd5d0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2282978-hgtIdeo_genome_367d73_ccd5d0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ANAPC13\u907a\u4f1d\u5b50\u4ed8\u8fd1\u306e<strong>rs10935120<\/strong>\uff08\u4ee3\u7406SNP rs1863913\uff09\uff08ANAPC13\u3068CEP63\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5f71\u97ff\uff09<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs10935120-hgtIdeo_genome_36c1a0_ccd870-1024x25.png\" alt=\"rs10935120\" class=\"wp-image-11344\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs10935120-hgtIdeo_genome_36c1a0_ccd870-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs10935120-hgtIdeo_genome_36c1a0_ccd870-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs10935120-hgtIdeo_genome_36c1a0_ccd870-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs10935120-hgtIdeo_genome_36c1a0_ccd870.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/24281301_s.jpg\" alt=\"\u5973\u6027\u8eab\u9577\u5dee\" class=\"wp-image-11351\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24281301_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24281301_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306f\u3001\u4eba\u9593\u306e\u8eab\u9577\u304c\u591a\u6570\u306e\u907a\u4f1d\u7684\u5909\u7570\u306b\u3088\u3063\u3066\u69cb\u6210\u3055\u308c\u308b\u3053\u3068\u3092\u518d\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u5404\u907a\u4f1d\u7684\u5909\u7570\u306e\u5f71\u97ff\u306f\u5c0f\u3055\u304f\uff08\u5404\u5bfe\u7acb\u907a\u4f1d\u5b50\u3054\u3068\u306b\u7d040.2\u301c0.6cm\uff09\u3001\u7279\u5b9a\u3055\u308c\u305f20\u306eSNP\u304c\u8aac\u660e\u3059\u308b\u8eab\u9577\u306e\u3070\u3089\u3064\u304d\u306f\u5168\u4f53\u306e\u7d043%\u306b\u3068\u3069\u307e\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u7a00\u306a\u907a\u4f1d\u7684\u5909\u7570\u3084\u30b3\u30d4\u30fc\u6570\u591a\u578b\uff08Copy Number Polymorphism: \u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u6570\u304c\u7570\u306a\u308b\u5909\u7570\uff09\u3092\u542b\u3080\u3001\u591a\u6570\u306e\u672a\u767a\u898b\u306e\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u91cf\u7684\u5f62\u8cea\uff08quantitative trait: \u8907\u6570\u306e\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u8981\u56e0\u306b\u5f71\u97ff\u3055\u308c\u308b\u5f62\u8cea\uff09\u306e\u907a\u4f1d\u7684\u8907\u96d1\u3055\u3092\u793a\u3057\u3001\u3055\u3089\u306a\u308b\u5927\u898f\u6a21\u306a\u89e3\u6790\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg\" alt=\"\" class=\"wp-image-11365\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u4e8c\u6bb5\u968e\u306e\u65b9\u6cd5\u3092\u63a1\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7b2c1\u6bb5\u968e\uff08GWA\uff09<\/strong>: \u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u306e13,665\u4eba\u304b\u3089\u5f97\u3089\u308c\u305f6\u3064\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u7d0450\u4e07\u7b87\u6240\u306eSNP\u3092\u540c\u6642\u306b\u89e3\u6790\u3067\u304d\u308bAffymetrix 500K\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u30c1\u30c3\u30d7\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u89e3\u6790\u7cbe\u5ea6\u3092\u9ad8\u3081\u308b\u305f\u3081\u53b3\u5bc6\u306a\u54c1\u8cea\u7ba1\u7406\u3092\u884c\u3044\u3001\u907a\u4f1d\u7684\u80cc\u666f\u306b\u3088\u308b\u5f71\u97ff\uff08population stratification\uff09\u3092\u88dc\u6b63\u3059\u308b\u7d71\u8a08\u624b\u6cd5\uff08EIGENSTRAT\uff09\u3092\u7528\u3044\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u7b2c2\u6bb5\u968e\uff08Follow-up\uff09<\/strong>: \u7b2c1\u6bb5\u968e\u3067\u7279\u5b9a\u3055\u308c\u305f39\u306e\u5019\u88dcSNP\u3092\u5bfe\u8c61\u306b\u8ffd\u52a0\u306716,482\u4eba\u306e\u89e3\u6790\u3092\u884c\u3044\u3001\u6709\u610f\u6027\uff08P &lt; 0.005\uff09\u3092\u793a\u3057\u305fSNP\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u907a\u4f1d\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\uff08gene-gene interaction\uff09\u3084\u6027\u5dee\u3001\u52a0\u9f62\u306e\u5f71\u97ff\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3078\u306e\u5f71\u97ff\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/24328543_s.jpg\" alt=\"\u30b5\u30a4\u30ba\" class=\"wp-image-11409\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24328543_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24328543_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u89e3\u6790\u306e\u7d50\u679c\u300120\u306eSNP\u304c\u8eab\u9577\u306e\u5dee\u306b\u95a2\u9023\u3059\u308b\u3068\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306eSNP\u304c\u8aac\u660e\u3059\u308b\u8eab\u9577\u306e\u3070\u3089\u3064\u304d\u306f\u7d043%\u3067\u3001\u591a\u304f\u306e\u300c\u9ad8\u8eab\u9577\u300d\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u6301\u3064\u7fa4\u3068\u305d\u3046\u3067\u306a\u3044\u7fa4\u306e\u9593\u306b\u306f\u7d045cm\u306e\u5dee\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u3084\u5e74\u9f62\u306b\u3088\u308b\u9055\u3044\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u3053\u308c\u3089\u306e\u5909\u7570\u306f\u4e3b\u306b\u6210\u9577\u671f\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u5f71\u97ff\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u30021\u3064\u306eSNP\uff08rs6440003\uff09\u306f\u5973\u6027\u3067\u3084\u3084\u5f37\u3044\u5f71\u97ff\u3092\u793a\u3057\u307e\u3057\u305f\u304c\u3001\u66f4\u306a\u308b\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1191695_s.jpg\" alt=\"\u307f\u3093\u306a\u9055\u3063\u3066\u307f\u3093\u306a\u3044\u3044\" class=\"wp-image-11372\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1191695_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1191695_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u300113,665\u4eba\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWA\uff09\u30c7\u30fc\u30bf\u306816,482\u4eba\u306e\u8ffd\u52a0\u89e3\u6790\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u6210\u4eba\u306e\u8eab\u9577\u306b\u95a2\u4e0e\u3059\u308b20\u306e\u30b2\u30ce\u30e0\u9818\u57df\uff08\u907a\u4f1d\u5b50\u5ea7\uff09\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u9818\u57df\u306b\u306f\u3001\u6210\u9577\u3084\u7d30\u80de\u5206\u5316\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u907a\u4f1d\u5b50\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u30d2\u30c8\u306e\u6b63\u5e38\u306a\u6210\u9577\u904e\u7a0b\u3092\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u65b0\u305f\u306a\u624b\u304c\u304b\u308a\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u540c\u5b9a\u3055\u308c\u305fSNP\u306e\u591a\u304f\u306f\u3001\u7d30\u80de\u5468\u671f\uff08cell cycle\uff09\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08extracellular matrix\uff09\u3001\u30cf\u30ea\u30cd\u30ba\u30df\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\uff08Hedgehog signaling\uff09\u3001\u67d3\u8272\u4f53\u69cb\u9020\u306e\u518d\u7de8\u6210\u3084\u30af\u30ed\u30de\u30c1\u30f3\u8abf\u7bc0\uff08chromatin remodeling\uff09\u306a\u3069\u3001\u8907\u6570\u306e\u751f\u7269\u5b66\u7684\u6a5f\u69cb\u3068\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\u306f\u304c\u3093\u3068\u3082\u95a2\u9023\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u6b63\u5e38\u306a\u8eab\u4f53\u767a\u9054\u3068\u816b\u760d\u5f62\u6210\u3068\u306e\u9593\u306b\u5171\u901a\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/22512259_s.jpg\" alt=\"\u306f\u308a\u306d\u305a\u307f\u304e\u3085\u3046\u3046\" class=\"wp-image-11387\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22512259_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22512259_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u3053\u308c\u3089\u306e20\u306eSNP\u306f\u5408\u308f\u305b\u3066\u8eab\u9577\u306e\u3070\u3089\u3064\u304d\u306e\u7d043%\u3057\u304b\u8aac\u660e\u3067\u304d\u305a\u3001\u4ed6\u306b\u3082\u591a\u304f\u306e\u5171\u901a\u5909\u7570\uff08common variants\uff09\u3084\u7a00\u306a\u5909\u7570\uff08rare variants\uff09\u3001\u69cb\u9020\u5909\u7570\uff08structural variants\uff09\u304c\u3001\u672a\u3060\u306b\u767a\u898b\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30d2\u30c8\u306e\u8eab\u9577\u306e\u907a\u4f1d\u7684\u30a2\u30fc\u30ad\u30c6\u30af\u30c1\u30e3\uff08genetic architecture\uff09\u304c\u975e\u5e38\u306b\u8907\u96d1\u3067\u3042\u308b\u3053\u3068\u304c\u518d\u8a8d\u8b58\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306a\u308b\u767a\u898b\u306e\u305f\u3081\u306b\u306f\u3001\u3088\u308a\u5927\u898f\u6a21\u306a\u7814\u7a76\u96c6\u56e3\u3068\u89e3\u6790\u624b\u6cd5\u306e\u9ad8\u5ea6\u5316\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u672c\u7814\u7a76\u306f\u3001\u65e2\u5b58\u306e\u9023\u9396\u89e3\u6790\u306e\u7d50\u679c\u3068\u672cGWA\u7814\u7a76\u306e\u7d50\u679c\u3068\u306e\u9593\u306b\u660e\u78ba\u306a\u91cd\u306a\u308a\u304c\u306a\u3044\u3053\u3068\u304b\u3089\u3001GWA\u3067\u691c\u51fa\u3055\u308c\u308b\u5171\u901a\u5909\u7570\u3068\u3001\u9023\u9396\u89e3\u6790\u3067\u898b\u3064\u304b\u308b\u9ad8\u6d78\u900f\u7387\u306e\u7a00\u306a\u5909\u7570\u3068\u306f\u7570\u306a\u308b\u907a\u4f1d\u7684\u5c64\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"428\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31840123_s.jpg\" alt=\"\u30ec\u30c3\u30b5\u30fc\u30d1\u30f3\u30c0\" class=\"wp-image-11395\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31840123_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31840123_s-300x201.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4ee5\u4e0a\u3088\u308a\u3001\u672c\u7814\u7a76\u306f\u6210\u4eba\u8eab\u9577\u306e\u907a\u4f1d\u7684\u6c7a\u5b9a\u8981\u56e0\u306e\u4e00\u90e8\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u4eca\u5f8c\u306e\u30d2\u30c8\u6210\u9577\u3001\u751f\u7269\u5b66\u7684\u767a\u9054\u3001\u304a\u3088\u3073\u95a2\u9023\u3059\u308b\u75be\u60a3\u7814\u7a76\u306b\u5bfe\u3057\u3066\u91cd\u8981\u306a\u51fa\u767a\u70b9\u3068\u306a\u308b\u77e5\u898b\u3092\u63d0\u4f9b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/25039671_s.jpg\" alt=\"\u3071\u3093\u3060\" class=\"wp-image-11402\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25039671_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25039671_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u6210\u4eba\u8eab\u9577, adult height, \u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790, genome-wide association analysis, \u4e00\u5869\u57fa\u591a\u578b, single nucleotide polymorphism (SNP), \u907a\u4f1d\u7684\u5909\u7570, genetic variation, \u30cf\u30ea\u30cd\u30ba\u30df\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def, Hedgehog signaling pathway, \u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9, extracellular matrix, \u304c\u3093\u95a2\u9023\u907a\u4f1d\u5b50, cancer-associated genes, \u907a\u4f1d\u7387, heritability, \u91cf\u7684\u5f62\u8cea, quantitative traits, \u907a\u4f1d\u5b50\u767a\u73fe, gene expression, \u7d71\u8a08\u7684\u6709\u610f\u6027, statistical significance, \u907a\u4f1d\u5b50\u9593\u76f8\u4e92\u4f5c\u7528, gene-gene interactions<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/ng.121\">Weedon, M. N., Lango, H., Lindgren, C. M., Wallace, C., Evans, D. M., Mangino, M., Freathy, R. M., Perry, J. R., Stevens, S., Hall, A. S., Samani, N. J., Shields, B., Prokopenko, I., Farrall, M., Dominiczak, A., Diabetes Genetics Initiative, Wellcome Trust Case Control Consortium, Johnson, T., Bergmann, S., Beckmann, J. S., \u2026 Frayling, T. M. (2008). Genome-wide association analysis identifies 20 loci that influence adult height.\u00a0<em>Nature genetics<\/em>,\u00a0<em>40<\/em>(5), 575\u2013583. https:\/\/doi.org\/10.1038\/ng.121<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u6210\u4eba\u8eab\u9577\uff08adult height\uff09\u306f\u4ee3\u8868\u7684\u306a\u591a\u907a\u4f1d\u5b50\u5f62\u8cea\uff08polygenic trait\uff09\u306e\u4e00\u4f8b\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u591a\u6570\u306e\u907a\u4f1d\u5b50\u304c\u5c11\u3057\u305a\u3064\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u307e\u3059\u3002\u8eab\u9577\u306f\u907a\u4f1d\u5b66\u7684\u7814\u7a76 [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":11292,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[267,265,275,268,262,273,280,272,283,242,282,266,249,281,276,225,264,277,269,271,279,263,59,284,274,270],"class_list":["post-11271","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-acan","tag-adamtsl3","tag-cdk6","tag-efemp1","tag-gwas","tag-hhip","tag-hmga2","tag-ihh","tag-ptch1","tag-snp","tag-282","tag-266","tag-249","tag-281","tag-276","tag-225","tag-264","tag-277","tag-269","tag-271","tag-279","tag-263","tag-59","tag-284","tag-274","tag-270"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11271","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=11271"}],"version-history":[{"count":5,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11271\/revisions"}],"predecessor-version":[{"id":11417,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11271\/revisions\/11417"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/11292"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=11271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=11271"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=11271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}