{"id":11418,"date":"2025-04-02T09:04:05","date_gmt":"2025-04-02T09:04:05","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=11418"},"modified":"2025-04-04T08:53:05","modified_gmt":"2025-04-04T08:53:05","slug":"aggression","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/aggression\/","title":{"rendered":"\u653b\u6483\u6027\u306f\u907a\u4f1d\u3067\u6c7a\u307e\u308b\uff1f\u3042\u306a\u305f\u306e\u6027\u683c\u306b\u5f71\u97ff\u3059\u308b\u201c\u4f53\u5185\u30b9\u30a4\u30c3\u30c1\u201d\u306e\u6b63\u4f53\u3068\u306f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<p>\u653b\u6483\u6027\uff08Aggressiveness\uff09\u306f\u3001\u52d5\u7269\u3084\u4eba\u9593\u3092\u542b\u3080\u591a\u304f\u306e\u7a2e\u306b\u304a\u3044\u3066\u3001\u751f\u5b58\u306b\u4e0d\u53ef\u6b20\u306a\u6a5f\u80fd\u3092\u679c\u305f\u3059\u8907\u96d1\u3067\u907a\u4f1d\u7684\u306a\u884c\u52d5\u7279\u6027\u3067\u3059\u3002\u7e04\u5f35\u308a\u306e\u9632\u885b\u3001\u5b50\u5b6b\u306e\u4fdd\u8b77\u3001\u793e\u4f1a\u7684\u968e\u5c64\u306e\u7dad\u6301\u306a\u3069\u3001\u7a2e\u306e\u4fdd\u5b58\u306b\u95a2\u308f\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u52d5\u7269\u884c\u52d5\u5b66\uff08ethology\uff09\u306e\u7814\u7a76\u3067\u306f\u3001\u653b\u6483\u6027\u304c\u4f4e\u3059\u304e\u308b\u3068\u500b\u4f53\u3084\u96c6\u56e3\u306e\u751f\u5b58\u9069\u5fdc\u304c\u56f0\u96e3\u3068\u306a\u308a\u3001\u4e00\u65b9\u3067\u904e\u5270\u306a\u653b\u6483\u6027\u3082\u793e\u4f1a\u7684\u30fb\u751f\u7269\u5b66\u7684\u306b\u6709\u5bb3\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u793e\u4f1a\u6027\u3092\u6301\u3064\u7a2e\u3067\u306f\u3001\u968e\u5c64\u69cb\u9020\u304c\u653b\u6483\u6027\u306e\u6291\u5236\u6a5f\u69cb\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32259941_s.jpg\" alt=\"\u5b50\u4f9b\u306b\u5bfe\u3059\u308b\u5371\u967a\u3092\u611f\u3058\u305f\u3089\u653b\u6483\u6027\u7206\u4e0a\u304c\u308a\u307e\u3059\" class=\"wp-image-11442\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32259941_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32259941_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u73fe\u4ee3\u4eba\u793e\u4f1a\u306b\u304a\u3044\u3066\u306f\u3001\u5236\u5fa1\u3055\u308c\u306a\u3044\u653b\u6483\u6027\u304c\u6df1\u523b\u306a\u793e\u4f1a\u554f\u984c\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u8eab\u4f53\u7684\u307e\u305f\u306f\u8a00\u8a9e\u7684\u66b4\u529b\u3068\u3057\u3066\u8868\u51fa\u3057\u307e\u3059\u3002\u4eba\u306e\u653b\u6483\u6027\u306f\u3001\u885d\u52d5\u7684\uff08\u5916\u7684\u523a\u6fc0\u306b\u3088\u308b\uff09\u304a\u3088\u3073\u75c5\u7406\u7684\uff08\u6c17\u5206\u969c\u5bb3\u3084\u4e0d\u5b89\u969c\u5bb3\u306b\u4f34\u3046\uff09\u306b\u5206\u985e\u3055\u308c\u3001\u8907\u6570\u306e\u5185\u7684\u30fb\u5916\u7684\u8981\u56e0\u306b\u3088\u308a\u8907\u96d1\u306b\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u591a\u304f\u306e\u7814\u7a76\u304c\u306a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u653b\u6483\u6027\u306e\u6c7a\u5b9a\u907a\u4f1d\u5b50\u306f\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u306e\u80cc\u666f\u306b\u306f\u3001\u795e\u7d4c\u5185\u5206\u6ccc\u7cfb\uff08neuroendocrine system\uff09\u3084\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08epigenetics\uff09\u306a\u3069\u3001\u907a\u4f1d\u7684\u304b\u3064\u591a\u56e0\u5b50\u7684\u306a\u8abf\u7bc0\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u5b58\u5728\u304c\u3042\u308a\u3001\u907a\u4f1d\u5b66\u7684\u89e3\u660e\u304c\u96e3\u3057\u3044\u8981\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/24019077_s.jpg\" alt=\"\u66b4\u529b\u3092\u632f\u308b\u5973\u6027\u306b\u7c21\u5358\u306b\u62d2\u3081\u306a\u3044\" class=\"wp-image-11449\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24019077_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24019077_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u56fd\u969b\u7684\u306a\u30b2\u30ce\u30e0\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u300c1000 Genomes Project\u300d\u306e\u767b\u5834\u306b\u3088\u308a\u3001\u30d2\u30c8\u96c6\u56e3\u306b\u304a\u3051\u308b\u5927\u898f\u6a21\u306a\u907a\u4f1d\u7684\u5909\u7570\u3001\u7279\u306b\u4e00\u5869\u57fa\u591a\u578b\uff08Single Nucleotide Polymorphism; SNP\uff09\u306e\u540c\u5b9a\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002SNP\u306f\u3001\u75be\u60a3\u306e\u611f\u53d7\u6027\u3001\u85ac\u5264\u53cd\u5fdc\u3001\u884c\u52d5\u7279\u6027\u3068\u3044\u3063\u305f\u591a\u69d8\u306a\u8868\u73fe\u578b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u91cd\u8981\u306a\u30de\u30fc\u30ab\u30fc\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306aSNP\u3092\u7ba1\u7406\u30fb\u89e3\u6790\u3059\u308b\u305f\u3081\u3001\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9\u30b2\u30ce\u30e0\uff08reference genome\uff09\u3092\u57fa\u76e4\u3068\u3057\u305f\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08\u4f8b\uff1adbSNP\u3001Ensembl\u3001UCSC Genome Browser\uff09\u304c\u6d3b\u7528\u3055\u308c\u3066\u304a\u308a\u3001SNP\u304c\u3069\u306e\u3088\u3046\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3084\u6a5f\u80fd\u3092\u5909\u5316\u3055\u305b\u308b\u304b\u3092\u691c\u8a3c\u3059\u308b\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/SNP-1024x576.jpg\" alt=\"SNP\" class=\"wp-image-11464\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SNP-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SNP-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SNP-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SNP-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SNP.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<p class=\"has-text-align-center\"><a href=\"https:\/\/www.genome.gov\/genetics-glossary\/Single-Nucleotide-Polymorphisms-SNPs\"><sup><em> \u4e00\u5869\u57fa\u591a\u578b<\/em><\/sup> <sup><em>(SNPs; <em>Single nucleotide polymorphisms<\/em>)<\/em>. (April 2, 2025). Retrieved 2 April 2025, from https:\/\/www.genome.gov\/genetics-glossary\/Single-Nucleotide-Polymorphisms-SNPs<\/sup><\/a><\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>SNP\u306e\u4e2d\u3067\u3082\u3001\u7279\u306b\u8ee2\u5199\u8abf\u7bc0\u9818\u57df\uff08regulatory region\uff09\u306b\u5b58\u5728\u3059\u308b\u5909\u7570\u306f\u3001\u653b\u6483\u6027\u306e\u3088\u3046\u306a\u591a\u56e0\u5b50\u7684\uff08polygenic\uff09\u6027\u8cea\u306b\u95a2\u9023\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5bfe\u3057\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30fc\u30c9\u9818\u57df\u306eSNP\u306f\u3001\u5358\u4e00\u907a\u4f1d\u5b50\u75be\u60a3\uff08monogenic disorder\uff09\u306b\u304a\u3044\u3066\u6a5f\u80fd\u3084\u69cb\u9020\u306e\u7834\u7dbb\u306b\u76f4\u7d50\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u56e0\u679c\u95a2\u4fc2\u306e\u89e3\u660e\u306b\u6709\u7528\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u8ee2\u5199\u958b\u59cb\u70b9\u306e\u4e0a\u6d41\u7d04\u221270\uff5e\u221220\u5869\u57fa\uff08bp\uff09\u306b\u5b58\u5728\u3059\u308bTATA\u30dc\u30c3\u30af\u30b9\u3068\u547c\u3070\u308c\u308b\u9818\u57df\u306b\u6ce8\u76ee\u3057\u307e\u3057\u305f\u3002TATA\u30dc\u30c3\u30af\u30b9\u306f\u3001TATA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08TATA-binding protein; TBP\uff09\u304c\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306e\u8ee2\u5199\u958b\u59cb\u3092\u8a98\u5c0e\u3059\u308b\u6975\u3081\u3066\u91cd\u8981\u306a\u9818\u57df\u3067\u3042\u308a\u3001\u305d\u306e\u69cb\u9020\u304c\u4fdd\u5b88\u7684\u304b\u3064\u89e3\u6790\u3057\u3084\u3059\u3044\u3053\u3068\u304b\u3089\u3001\u8a08\u7b97\u4e88\u6e2c\u306b\u9069\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"778\" height=\"474\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P20226-F1.png\" alt=\"TATA-box-binding protein\" class=\"wp-image-11478\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P20226-F1.png 778w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P20226-F1-300x183.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P20226-F1-768x468.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08\u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1575244_s-1.jpg\" alt=\"\u8abf\u3079\u308b\" class=\"wp-image-11485\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1575244_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1575244_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u653b\u6483\u6027\u3068\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u308bSNP\u3092\u63a2\u7d22\u3059\u308b\u305f\u3081\u3001\u672c\u7814\u7a76\u3067\u306f\u4ee5\u4e0b\u306e2\u6bb5\u968e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63a1\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>SNP_TATA_Comparator<\/strong>\uff1a\u30d2\u30c8\u907a\u4f1d\u5b50\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u304a\u3051\u308bSNP\u304cTBP\u306e\u7d50\u5408\u89aa\u548c\u6027\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u6570\u5024\u7684\u306b\u8a55\u4fa1\u3059\u308bWeb\u30d9\u30fc\u30b9\u306e\u30c4\u30fc\u30eb\u3002<\/li>\n\n\n\n<li><strong>PubMed\u3092\u7528\u3044\u305f\u6587\u732e\u691c\u7d22<\/strong>\uff1a\u653b\u6483\u6027\u306b\u95a2\u9023\u3059\u308b\u30ad\u30fc\u30ef\u30fc\u30c9\u3092\u7528\u3044\u3066\u3001SNP\u3068\u884c\u52d5\u8868\u73fe\u578b\u306e\u95a2\u4fc2\u3092\u793a\u3059\u7814\u7a76\u3084\u75c7\u4f8b\u5831\u544a\u3092\u8abf\u67fb\u3002<\/li>\n<\/ol>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u5168\u4f53\u306733\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u5b58\u5728\u3059\u308b493\u306eSNP\u3092\u8a55\u4fa1\u3057\u305f\u7d50\u679c\u3001\u305d\u306e\u3046\u306128\uff08\u7d046%\uff09\u304cTBP\u306e\u7d50\u5408\u89aa\u548c\u6027\u306b\u6709\u610f\u306a\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u3068\u4e88\u6e2c\u3055\u308c\u3001\u653b\u6483\u6027\u306b\u95a2\u9023\u3059\u308b\u5019\u88dcSNP\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306eSNP\u304c\u95a2\u4e0e\u3059\u308b\u4ee3\u8868\u7684\u306a\u907a\u4f1d\u5b50\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"1001\" height=\"594\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P20226-F1-1.png\" alt=\"TBP hydrophobicity\" class=\"wp-image-11492\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P20226-F1-1.png 1001w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P20226-F1-1-300x178.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P20226-F1-1-768x456.png 768w\" sizes=\"(max-width: 1001px) 100vw, 1001px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31944675_s.jpg\" alt=\"\u7768\u3093\u3067\u308b\u5973\u6027\" class=\"wp-image-11499\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31944675_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31944675_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GH1\uff08\u6210\u9577\u30db\u30eb\u30e2\u30f31; Growth Hormone 1\uff09<\/strong>\uff1ars11568827\u3001rs796237787 \u306a\u3069\uff08\u4f4e\u8eab\u9577\u75c7\u5019\u7fa4\u3068\u7cbe\u795e\u75c7\u72b6\u306b\u95a2\u9023\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs11568827-hgtIdeo_genome_318879_cf5770-1024x25.png\" alt=\"rs11568827\" class=\"wp-image-11506\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs11568827-hgtIdeo_genome_318879_cf5770-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs11568827-hgtIdeo_genome_318879_cf5770-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs11568827-hgtIdeo_genome_318879_cf5770-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs11568827-hgtIdeo_genome_318879_cf5770.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL1B\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f31\u03b2\uff09<\/strong>\uff1ars1143627\u3001rs549858786\uff08\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u6cbb\u7642\u3084\u900f\u6790\u4e2d\u306e\u653b\u6483\u6027\u3068\u95a2\u9023\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs1143627-hgtIdeo_genome_31cfa0_cf59a0-1024x25.png\" alt=\"rs1143627\" class=\"wp-image-11513\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1143627-hgtIdeo_genome_31cfa0_cf59a0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1143627-hgtIdeo_genome_31cfa0_cf59a0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1143627-hgtIdeo_genome_31cfa0_cf59a0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1143627-hgtIdeo_genome_31cfa0_cf59a0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SOD1\uff08\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc1\uff09<\/strong>\uff1ars7277748\uff08ALS\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u653b\u6483\u6027\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs7277748-hgtIdeo_genome_31ecfc_cf5ba0-1024x25.png\" alt=\"rs7277748\" class=\"wp-image-11520\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7277748-hgtIdeo_genome_31ecfc_cf5ba0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7277748-hgtIdeo_genome_31ecfc_cf5ba0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7277748-hgtIdeo_genome_31ecfc_cf5ba0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7277748-hgtIdeo_genome_31ecfc_cf5ba0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>StAR\uff08\u30b9\u30c6\u30ed\u30a4\u30c9\u751f\u6210\u6025\u6027\u8abf\u7bc0\u30bf\u30f3\u30d1\u30af\u8cea\uff09<\/strong>\uff1ars544850971\u3001rs16887226\uff08\u9ad8\u9f62\u5973\u6027\u306e\u653b\u6483\u6027\u30fb\u7cd6\u5c3f\u75c5\u30fb\u9ad8\u8840\u5727\u3068\u95a2\u9023\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs544850971-hgtIdeo_genome_32261f_cf5dd0-1024x25.png\" alt=\"rs544850971\" class=\"wp-image-11527\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs544850971-hgtIdeo_genome_32261f_cf5dd0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs544850971-hgtIdeo_genome_32261f_cf5dd0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs544850971-hgtIdeo_genome_32261f_cf5dd0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs544850971-hgtIdeo_genome_32261f_cf5dd0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NOS2\uff08\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d202\uff09<\/strong>\uff1a\u221251 T\u2192C\uff08\u925b\u66dd\u9732\u74b0\u5883\u4e0b\u306e\u6027\u5dee\u653b\u6483\u6027\u30fb\u3066\u3093\u304b\u3093\u3068\u95a2\u9023\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/NOS2-hgtIdeo_genome_cd84d_cf5fa0-1024x25.png\" alt=\"NOS2\" class=\"wp-image-11534\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/NOS2-hgtIdeo_genome_cd84d_cf5fa0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/NOS2-hgtIdeo_genome_cd84d_cf5fa0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/NOS2-hgtIdeo_genome_cd84d_cf5fa0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/NOS2-hgtIdeo_genome_cd84d_cf5fa0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ESR2\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u03b2\uff09<\/strong>\uff1ars35036378\u3001rs766797386\uff08\u30d3\u30b9\u30d5\u30a7\u30ce\u30fc\u30ebA\u66dd\u9732\u5150\u306b\u304a\u3051\u308b\u653b\u6483\u6027\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs35036378-hgtIdeo_genome_d1f81_cf6150-1024x25.png\" alt=\"rs35036378\" class=\"wp-image-11541\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs35036378-hgtIdeo_genome_d1f81_cf6150-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs35036378-hgtIdeo_genome_d1f81_cf6150-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs35036378-hgtIdeo_genome_d1f81_cf6150-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs35036378-hgtIdeo_genome_d1f81_cf6150.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HBB\/HBD\uff08\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u03b2\/\u03b4\uff09<\/strong>\uff1a\u8907\u6570\u306eSNP\uff08\u30b5\u30e9\u30bb\u30df\u30a2\u3068\u5c0f\u5150\u306e\u653b\u6483\u6027\u306b\u95a2\u9023\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/HBB-hgtIdeo_genome_d49fb_cf6310-1024x25.png\" alt=\"HBB\" class=\"wp-image-11548\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/HBB-hgtIdeo_genome_d49fb_cf6310-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/HBB-hgtIdeo_genome_d49fb_cf6310-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/HBB-hgtIdeo_genome_d49fb_cf6310-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/HBB-hgtIdeo_genome_d49fb_cf6310.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PGR\uff08\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u53d7\u5bb9\u4f53\uff09<\/strong>\uff1ars10895068\uff08\u80a5\u6e80\u5973\u6027\u306b\u304a\u3051\u308b\u653b\u6483\u6027\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs10895068-hgtIdeo_genome_d80ef_cf6580-1024x25.png\" alt=\"rs10895068\" class=\"wp-image-11555\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs10895068-hgtIdeo_genome_d80ef_cf6580-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs10895068-hgtIdeo_genome_d80ef_cf6580-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs10895068-hgtIdeo_genome_d80ef_cf6580-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs10895068-hgtIdeo_genome_d80ef_cf6580.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>LEP\uff08\u30ec\u30d7\u30c1\u30f3\uff09<\/strong>\uff1ars201381696\u3001rs200487063\u3001rs34104384\uff08\u80a5\u6e80\u306b\u4f34\u3046\u653b\u6483\u6027\u3001\u5b9f\u9a13\u7684\u306b\u691c\u8a3c\uff09<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs201381696-hgtIdeo_genome_dbb63_cf6760-1024x25.png\" alt=\"rs201381696\" class=\"wp-image-11562\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs201381696-hgtIdeo_genome_dbb63_cf6760-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs201381696-hgtIdeo_genome_dbb63_cf6760-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs201381696-hgtIdeo_genome_dbb63_cf6760-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs201381696-hgtIdeo_genome_dbb63_cf6760.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001TBP\u7d50\u5408\u90e8\u4f4d\u306b\u304a\u3051\u308bSNP\u306e\u89aa\u548c\u6027\u5909\u5316\u304b\u3089\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5909\u5316\u3092\u4e88\u6e2c\u3057\u3001\u305d\u308c\u3092\u901a\u3058\u3066\u653b\u6483\u6027\u3068\u95a2\u4fc2\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5019\u88dcSNP\u30de\u30fc\u30ab\u30fc\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002493\u500b\u306eSNP\u306e\u3046\u30616%\u306e\u307f\u304cTBP\u7d50\u5408\u89aa\u548c\u6027\u306b\u6709\u610f\u306a\u5909\u5316\u3092\u793a\u3057\u307e\u3057\u305f\u304c\u3001\u6b8b\u308a\u306eSNP\u3082\u4ed6\u306e\u8ee2\u5199\u56e0\u5b50\u306e\u7d50\u5408\u90e8\u4f4d\u306a\u3069\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u5225\u306e\u30c4\u30fc\u30eb\u3084\u624b\u6cd5\u3067\u306e\u8ffd\u52a0\u89e3\u6790\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31654070_s.jpg\" alt=\"KO\" class=\"wp-image-11569\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31654070_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31654070_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u3053\u3067\u63d0\u793a\u3055\u308c\u305f\u5019\u88dcSNP\u306f\u3001\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u5909\u7570\uff08causative mutation\uff09\u3067\u306f\u306a\u304f\u3001\u653b\u6483\u6027\u306a\u3069\u591a\u56e0\u5b50\u6027\u5f62\u8cea\u306b\u5bfe\u3059\u308b\u4e88\u6e2c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08genomic biomarker\uff09\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u3001\u500b\u5225\u5316\u533b\u7642\uff08personalized medicine\uff09\u306b\u304a\u3051\u308b\u4e88\u9632\u30fb\u6cbb\u7642\u306e\u6307\u91dd\u3068\u306a\u308a\u5f97\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs201381696\uff08LEP\uff09<\/strong>\u3092\u4fdd\u6709\u3059\u308b10\u6b73\u306e\u653b\u6483\u7684\u306a\u5973\u5150\u306f\u3001\u601d\u6625\u671f\u306e\u80a5\u6e80\u3084\u5fc3\u8840\u7ba1\u5408\u4f75\u75c7\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306e\u751f\u6d3b\u7fd2\u6163\u6539\u5584\uff08\u98df\u4e8b\u30fb\u904b\u52d5\uff09\u3092\u65e9\u671f\u306b\u958b\u59cb\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"428\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/30226224_s.jpg\" alt=\"\u512a\u3057\u3044\u5473\u304b\u3089\u512a\u3057\u3044\u6027\u683c\u3078\" class=\"wp-image-11576\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30226224_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30226224_s-300x201.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs1143627\uff08IL1B\uff09<\/strong>\u3092\u4fdd\u6709\u3059\u308b\u60a3\u8005\u306b\u306f\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u6cbb\u7642\u3068\u4e26\u884c\u3057\u3066\u6297\u653b\u6483\u6027\u85ac\u306e\u51e6\u65b9\u304c\u6709\u7528\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"776\" height=\"666\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/7I1B.png\" alt=\"7I1B\" class=\"wp-image-11583\" style=\"width:662px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/7I1B.png 776w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/7I1B-300x257.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/7I1B-768x659.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs35036378\uff08ESR2\uff09<\/strong>\u3092\u6301\u3064\u5150\u7ae5\u304c\u3044\u308b\u5bb6\u5ead\u3067\u306f\u3001\u73a9\u5177\u306a\u3069\u306e\u30d3\u30b9\u30d5\u30a7\u30ce\u30fc\u30ebA\uff08BPA\uff09\u542b\u6709\u88fd\u54c1\u3078\u306e\u6ce8\u610f\u304c\u4fc3\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4444608_s.jpg\" alt=\"BPA\" class=\"wp-image-11590\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4444608_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4444608_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NOS2\u907a\u4f1d\u5b50\u306e\u221251 T\u2192C\u5909\u7570<\/strong>\u3092\u6301\u3064\u7537\u6027\u306f\u3001\u925b\u66dd\u9732\u304c\u653b\u6483\u6027\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8003\u616e\u3057\u3066\u751f\u6d3b\u74b0\u5883\u3092\u898b\u76f4\u3059\u5fc5\u8981\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/22975239_s.jpg\" alt=\"\u925b\" class=\"wp-image-11597\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22975239_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22975239_s-300x169.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306eSNP\u306b\u95a2\u3059\u308b\u6587\u732e\u306f\u3001\u533b\u5b66\u3001\u85ac\u7406\u5b66\u3001\u907a\u4f1d\u5b66\u3001\u5fc3\u7406\u5b66\u3001\u74b0\u5883\u79d1\u5b66\u306a\u3069\u3001\u591a\u304f\u306e\u5206\u91ce\u306b\u307e\u305f\u304c\u308b\u77e5\u898b\u306b\u57fa\u3065\u3044\u3066\u304a\u308a\u3001\u653b\u6483\u6027\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u591a\u5206\u91ce\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u91cd\u8981\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u5404SNP\u306e\u5b9f\u9a13\u691c\u8a3c\u3092\u884c\u3046\u305f\u3081\u306e\u5b9a\u91cf\u6307\u6a19\u3068\u3057\u3066\u3001TBP\u3068DNA\u3068\u306e\u7d50\u5408\u89aa\u548c\u6027\uff08\u5e73\u8861\u89e3\u96e2\u5b9a\u6570\uff1aKd\uff09\u3092\u30ca\u30ce\u30e2\u30eb\u6fc3\u5ea6\uff08nM\uff09\u5358\u4f4d\u3067\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001<strong>in vitro\uff08\u8a66\u9a13\u7ba1\u5185\uff09\u304a\u3088\u3073\u81e8\u5e8a\u7814\u7a76<\/strong>\u306b\u304a\u3051\u308b\u691c\u8a3c\u8a2d\u8a08\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d30\u80de\u57f9\u990a\u3068\u30ec\u30dd\u30fc\u30bf\u30fc\u30a2\u30c3\u30bb\u30a4<\/h3>\n\n\n\n<p>LEP\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5909\u5316\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u30d2\u30c8\u7d50\u8178\u817a\u764c\u7d30\u80de\u682aHCT116\u3068\u4e73\u817a\u764c\u7d30\u80de\u682aMCF-7\u3092\u4f7f\u7528\u3002SNP rs201381696\u306e\u5148\u7956\u578b\u304a\u3088\u3073\u30de\u30a4\u30ca\u30fc\u30a2\u30ec\u30eb\u3092\u542b\u3080\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u914d\u5217\u3092pGL4.10\u30d9\u30af\u30bf\u30fc\u306b\u7d44\u307f\u8fbc\u307f\u3001\u30eb\u30b7\u30d5\u30a7\u30e9\u30fc\u30bc\uff08Luciferase\uff09\u3092\u30ec\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\u3068\u3057\u3066\u767a\u73fe\u3055\u305b\u305f\u3002\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\u5f8c24\u6642\u9593\u3067\u3001\u767a\u5149\u91cf\u306b\u3088\u308a\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u6d3b\u6027\u3092\u5b9a\u91cf\u5316\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"425\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3451700_s.jpg\" alt=\"\u86cd\" class=\"wp-image-11604\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3451700_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3451700_s-300x199.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">DNA\u914d\u5217\u89e3\u6790<\/h3>\n\n\n\n<p>\u30d2\u30c8\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9\u30b2\u30ce\u30e0\u304b\u3089\u53d6\u5f97\u3057\u305f\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u914d\u5217\u3092<strong>BioPerl<\/strong>\u30e9\u30a4\u30d6\u30e9\u30ea\u3067\u51e6\u7406\u3057\u3001\u221270\uff5e\u221220 bp\u306e\u9818\u57df\u306b\u4f4d\u7f6e\u3059\u308bSNP\u3092<strong>SNP_TATA_Comparator<\/strong>\u3067\u89e3\u6790\u3002TBP\u306e\u7d50\u5408\u89aa\u548c\u6027\u5909\u5316\u3092\u7d71\u8a08\u7684\u306b\u6bd4\u8f03\u3057\u3001\u6709\u610f\u5dee\u306e\u3042\u308b\u5909\u7570\u3092\u62bd\u51fa\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32049334_s.jpg\" alt=\"\u30cf\u30b0\" class=\"wp-image-11611\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32049334_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32049334_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\u691c\u7d22<\/h3>\n\n\n\n<p>\u5404SNP\u306e\u5f71\u97ff\u304c\u81e8\u5e8a\u7684\u306b\u653b\u6483\u6027\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u3001<strong>NCBI<\/strong>\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u30672\u6bb5\u968e\u306e\u30ad\u30fc\u30ef\u30fc\u30c9\u691c\u7d22\u3092\u5b9f\u65bd\u3002\u4e00\u6b21\u691c\u7d22\u3067\u306f\u3001\u653b\u6483\u6027\u304c\u75c7\u72b6\u3068\u3057\u3066\u542b\u307e\u308c\u308b\u75be\u60a3\u3092\u62bd\u51fa\u3057\u3001\u4e8c\u6b21\u691c\u7d22\u3067\u306f\u305d\u306e\u75be\u60a3\u3068\u8a72\u5f53SNP\u3068\u306e\u95a2\u9023\u6587\u732e\u3092\u8abf\u67fb\u3002\u75c7\u4f8b\u5831\u544a\u3001\u30ec\u30d3\u30e5\u30fc\u8ad6\u6587\u3001\u5b9f\u9a13\u30c7\u30fc\u30bf\u306a\u3069\u3092\u53ce\u96c6\u3057\u3001\u8868\u5f62\u5f0f\u3067\u6574\u7406\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31952038_s-1.jpg\" alt=\"\u304a\u8aad\u307f\u3057\u307e\u3059\" class=\"wp-image-11618\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31952038_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31952038_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GH1\u95a2\u9023SNP<\/strong>\uff1a\u4f4e\u8eab\u9577\u75c7\u5019\u7fa4\u3084\u7cbe\u795e\u7684\u4e0d\u5b89\u5b9a\u3055\u3068\u306e\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>IL1B rs1143627<\/strong>\uff1a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u6cbb\u7642\u3084\u900f\u6790\u4e2d\u306e\u653b\u6483\u6027\u5897\u52a0\u306b\u95a2\u4e0e\u3002<\/li>\n\n\n\n<li><strong>SOD1 rs7277748<\/strong>\uff1aALS\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u6cbb\u7642\u4e2d\u306e\u653b\u6483\u6027\u306b\u95a2\u9023\u3002<\/li>\n\n\n\n<li><strong>StAR rs544850971<\/strong>\uff1a\u9ad8\u9f62\u5973\u6027\u306e\u7cd6\u5c3f\u75c5\u30fb\u9ad8\u8840\u5727\u30fb\u653b\u6483\u6027\u3068\u306e\u95a2\u9023\u304c\u4e88\u6e2c\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>NOS2 \u221251 T\u2192C<\/strong>\uff1a\u925b\u66dd\u9732\u4e0b\u306e\u7537\u6027\u306b\u304a\u3051\u308b\u653b\u6483\u6027\u5897\u52a0\u3092\u4e88\u6e2c\u3002<\/li>\n\n\n\n<li><strong>ESR2 rs35036378<\/strong>\uff1a\u30d3\u30b9\u30d5\u30a7\u30ce\u30fc\u30ebA\u66dd\u9732\u306b\u3088\u308b\u5c0f\u5150\u306e\u653b\u6483\u6027\u306b\u95a2\u4e0e\u3002<\/li>\n\n\n\n<li><strong>HBB\/HBD SNP\u7fa4<\/strong>\uff1a\u30b5\u30e9\u30bb\u30df\u30a2\u3068\u653b\u6483\u6027\u306e\u4f75\u767a\u3002<\/li>\n\n\n\n<li><strong>PGR rs10895068<\/strong>\uff1a\u80a5\u6e80\u5973\u6027\u306e\u653b\u6483\u7684\u50be\u5411\u306b\u95a2\u4e0e\u3002<\/li>\n\n\n\n<li><strong>LEP SNP\u7fa4<\/strong>\uff1a\u907a\u4f1d\u5b50\u767a\u73fe\u6291\u5236\u304c\u5b9f\u9a13\u7684\u306b\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u80a5\u6e80\u3068\u653b\u6483\u6027\u306e\u95a2\u9023\u306b\u5bc4\u4e0e\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31736353_s.jpg\" alt=\"\u304a\u3089\u3088\" class=\"wp-image-11625\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31736353_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31736353_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u4e88\u6e2c\u3055\u308c\u305f28\u500b\u306e\u653b\u6483\u6027\u95a2\u9023\u5019\u88dcSNP\u30de\u30fc\u30ab\u30fc\u306f\u3001\u81e8\u5e8a\u7684\u691c\u8a3c\u3092\u7d4c\u308b\u3053\u3068\u3067\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u4e00\u74b0\u3068\u3057\u3066\u4e88\u9632\u3084\u6cbb\u7642\u306b\u6d3b\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\u533b\u5e2b\u306b\u3088\u308b\u6cbb\u7642\u8a08\u753b\u306e\u6700\u9069\u5316\u3060\u3051\u3067\u306a\u304f\u3001\u500b\u4eba\u306e\u751f\u6d3b\u7fd2\u6163\u306e\u9078\u629e\u3084\u74b0\u5883\u8981\u56e0\u3078\u306e\u5bfe\u5fdc\u306b\u3082\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5168\u30b2\u30ce\u30e0\u30ec\u30d9\u30eb\u306e\u30e9\u30f3\u30c9\u30de\u30fc\u30af\u306f\u3001\u653b\u6483\u6027\u3068\u3044\u3046\u8907\u96d1\u306a\u884c\u52d5\u8868\u73fe\u578b\u306e\u80cc\u666f\u306b\u3042\u308b\u907a\u4f1d\u7684\u8981\u7d20\u306e\u7406\u89e3\u3092\u6df1\u5316\u3055\u305b\u308b\u91cd\u8981\u306a\u624b\u304c\u304b\u308a\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31994045_s.jpg\" alt=\"\u305f\u3072\" class=\"wp-image-11632\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31994045_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31994045_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u653b\u6483\u6027\uff5cAggressiveness, \u907a\u4f1d\u5b50\uff5cGene, \u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\uff5cPromoter, TATA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff5cTATA-binding protein, \u4e00\u5869\u57fa\u591a\u578b\uff5cSingle nucleotide polymorphism, \u5019\u88dcSNP\u30de\u30fc\u30ab\u30fc\uff5cCandidate SNP marker, \u30ad\u30fc\u30ef\u30fc\u30c9\u691c\u7d22\uff5cKeyword-based search, \u30a4\u30f3\u30b7\u30ea\u30b3\u4e88\u6e2c\uff5cPrediction in silico<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32029542_s.jpg\" alt=\"pochi\" class=\"wp-image-11435\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32029542_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32029542_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1186\/s12864-016-3353-3\">Chadaeva, I. V., Ponomarenko, M. P., Rasskazov, D. A., Sharypova, E. B., Kashina, E. V., Matveeva, M. Y., Arshinova, T. V., Ponomarenko, P. M., Arkova, O. V., Bondar, N. P., Savinkova, L. K., &amp; Kolchanov, N. A. (2016). Candidate SNP markers of aggressiveness-related complications and comorbidities of genetic diseases are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters.\u00a0<em>BMC genomics<\/em>,\u00a0<em>17<\/em>(Suppl 14), 995. https:\/\/doi.org\/10.1186\/s12864-016-3353-3<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.2210\/rcsb_pdb\/mom_2005_7\">Goodsell, D. S. (2005). Tata-binding protein.\u00a0<em>RCSB Protein Data Bank<\/em>. https:\/\/doi.org\/10.2210\/rcsb_pdb\/mom_2005_7<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u653b\u6483\u6027\uff08Aggressiveness\uff09\u306f\u3001\u52d5\u7269\u3084\u4eba\u9593\u3092\u542b\u3080\u591a\u304f\u306e\u7a2e\u306b\u304a\u3044\u3066\u3001\u751f\u5b58\u306b\u4e0d\u53ef\u6b20\u306a\u6a5f\u80fd\u3092\u679c\u305f\u3059\u8907\u96d1\u3067\u907a\u4f1d\u7684\u306a\u884c\u52d5\u7279\u6027\u3067\u3059\u3002\u7e04\u5f35\u308a\u306e\u9632\u885b\u3001\u5b50\u5b6b\u306e\u4fdd\u8b77\u3001\u793e\u4f1a\u7684\u968e\u5c64\u306e\u7dad\u6301\u306a\u3069\u3001\u7a2e\u306e\u4fdd\u5b58\u306b\u95a2\u308f [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":11456,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[305,242,301,297,303,294,293,304,295,299,289,307,286,290,225,41,302,300,291,308,298,287,296,292,306,285,311,288,36,278,310,309],"class_list":["post-11418","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-als","tag-snp","tag-snp_tata_comparator","tag-tata","tag-tbp","tag-294","tag-293","tag-304","tag-295","tag-299","tag-289","tag-a","tag-286","tag-290","tag-225","tag-personalized-medicine","tag-302","tag-300","tag-291","tag-308","tag-298","tag-287","tag-296","tag-292","tag-306","tag-285","tag-311","tag-288","tag-gene-testing","tag-278","tag-310","tag-309"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=11418"}],"version-history":[{"count":5,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11418\/revisions"}],"predecessor-version":[{"id":11639,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11418\/revisions\/11639"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/11456"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=11418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=11418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=11418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}