{"id":11710,"date":"2025-04-04T01:36:39","date_gmt":"2025-04-04T01:36:39","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=11710"},"modified":"2025-04-04T08:53:04","modified_gmt":"2025-04-04T08:53:04","slug":"fto","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/fto\/","title":{"rendered":"\u300c\u592a\u308a\u3084\u3059\u3055\u300d\u306f\u907a\u4f1d\u3067\u6c7a\u307e\u308b\uff1fFTO\u907a\u4f1d\u5b50\u304c\u6559\u3048\u3066\u304f\u308c\u308b\u80a5\u6e80\u306e\u65b0\u5e38\u8b58"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u80cc\u666f\uff5cBackground<\/strong><\/h2>\n\n\n\n<p>\u80a5\u6e80\u306f\u4e16\u754c\u7684\u306a\u5065\u5eb7\u5371\u6a5f\u3067\u3042\u308a\u30012\u578b\u7cd6\u5c3f\u75c5\uff08type 2 diabetes mellitus\uff09\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\uff08cardiovascular disease\uff09\u3001\u9ad8\u8840\u5727\uff08hypertension\uff09\u3001\u8133\u5352\u4e2d\uff08stroke\uff09\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\uff08metabolic syndrome\uff09\u3001\u3055\u3089\u306b\u8907\u6570\u306e\u304c\u3093\uff08\u305f\u3068\u3048\u3070\u5927\u8178\u304c\u3093\u3001\u4e73\u304c\u3093\u3001\u5b50\u5bae\u5185\u819c\u304c\u3093\uff09\u3092\u542b\u3080\u591a\u304f\u306e\u6162\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u8457\u3057\u304f\u9ad8\u3081\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23530957_s.jpg\" alt=\"\u3069\u3069\u3093\" class=\"wp-image-11750\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23530957_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23530957_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u80a5\u6e80\u306f\u901a\u5e38\u3001\u300c\u4f53\u683c\u6307\u6570\uff08BMI\uff1aBody Mass Index\uff09\u300d\u306b\u3088\u3063\u3066\u5b9a\u91cf\u5316\u3055\u308c\u3001\u4f53\u91cd\uff08kg\uff09\u3092\u8eab\u9577\uff08m\uff09\u306e\u4e8c\u4e57\u3067\u5272\u308b\u3053\u3068\u3067\u7b97\u51fa\u3055\u308c\u307e\u3059\u3002BMI\u304c25 kg\/m\u00b2\u4ee5\u4e0a\u306e\u5834\u5408\u306f\u904e\u4f53\u91cd\uff08overweight\uff09\u300130 kg\/m\u00b2\u4ee5\u4e0a\u306f\u80a5\u6e80\uff08obesity\uff09\u3068\u5206\u985e\u3055\u308c\u3001\u3053\u308c\u3089\u306e\u6307\u6a19\u306f\u75ab\u5b66\u7814\u7a76\u306b\u304a\u3044\u3066\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u30022003\u301c2004\u5e74\u306e\u7c73\u56fd\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u3001\u4eba\u53e3\u306e\u7d0466\uff05\u304cBMI 25\u4ee5\u4e0a\u3067\u3042\u308a\u3001\u305d\u306e\u3046\u306132\uff05\u304c\u80a5\u6e80\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u9ad8\u30ab\u30ed\u30ea\u30fc\u306a\u98df\u751f\u6d3b\u3084\u8eab\u4f53\u6d3b\u52d5\u306e\u4e0d\u8db3\u3068\u3044\u3063\u305f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u8981\u56e0\u304c\u80a5\u6e80\u306e\u4e3b\u56e0\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u907a\u4f1d\u7684\u7d20\u56e0\uff08genetic predisposition\uff09\u3082\u500b\u4eba\u306e\u80a5\u6e80\u30ea\u30b9\u30af\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u5375\u6027\u30fb\u4e8c\u5375\u6027\u53cc\u751f\u5150\u7814\u7a76\uff08twin studies\uff09\u3084\u990a\u5b50\u7e01\u7d44\u7814\u7a76\uff08adoption studies\uff09\u3067\u306f\u3001\u4f53\u91cd\u8abf\u7bc0\u306b\u95a2\u3059\u308b\u5f37\u3044\u907a\u4f1d\u7684\u5f71\u97ff\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u3053\u308c\u307e\u3067\u306b\u5b9f\u65bd\u3055\u308c\u3066\u304d\u305f\u5019\u88dc\u907a\u4f1d\u5b50\u7814\u7a76\uff08candidate gene studies\uff09\u3084\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790\uff08GWAS\uff1agenome-wide association studies\uff09\u3067\u306f\u3001\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308b\u80a5\u6e80\u3068\u78ba\u5b9f\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u591a\u578b\u306e\u7279\u5b9a\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002\u5358\u4e00\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u30e2\u30ce\u30b8\u30a7\u30cb\u30c3\u30af\u80a5\u6e80\uff08monogenic obesity\uff09\u306f\u3001\u5c0f\u5150\u671f\u306e\u91cd\u5ea6\u304b\u3064\u65e9\u671f\u767a\u75c7\u578b\u80a5\u6e80\u306e\u7d047\uff05\u3092\u5360\u3081\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u5168\u4eba\u53e3\u306e0.01\uff05\u672a\u6e80\u3068\u3044\u3046\u6975\u3081\u3066\u7a00\u306a\u30b1\u30fc\u30b9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3068\u3048\u3070<strong>GAD2<\/strong>\uff08\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u95a2\u9023\uff09\u3001<strong>ENPP1<\/strong>\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u306b\u95a2\u4e0e\uff09\u3001<strong>INSIG2<\/strong>\uff08\u8102\u8cea\u4ee3\u8b1d\u95a2\u9023\uff09\u306a\u3069\u306e\u907a\u4f1d\u5b50\u306b\u304a\u3044\u3066\u4e00\u90e8\u6709\u671b\u306a\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u591a\u304f\u306e\u7814\u7a76\u3067\u518d\u73fe\u6027\u304c\u306a\u304f\u3001\u7d50\u679c\u306e\u4fe1\u983c\u6027\u306b\u306f\u9650\u754c\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"540\" height=\"568\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9C0B1-F1.png\" alt=\"Alpha-ketoglutarate-dependent dioxygenase FTO\" class=\"wp-image-11820\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9C0B1-F1.png 540w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9C0B1-F1-285x300.png 285w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u304c\u5c0f\u3055\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u591a\u56e0\u5b50\u6027\u80a5\u6e80\uff08polygenic obesity\uff09<strong>\u306e<\/strong>\u907a\u4f1d\u7684\u69cb\u9020\uff08genetic architecture\uff09\u306f\u6975\u3081\u3066\u8907\u96d1\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3046\u3057\u305f\u80cc\u666f\u306e\u306a\u304b\u3001Wellcome Trust Case Control Consortium\uff08WTCCC\uff09\u306e\u7814\u7a76\u306b\u3088\u308a\u3001FTO\u907a\u4f1d\u5b50\uff08fat mass and obesity-associated gene\uff09<strong>\u306b\u3042\u308b<\/strong>\u4e00\u5869\u57fa\u591a\u578b\uff08SNP\uff1asingle nucleotide polymorphism\uff09<strong>\u304cBMI\u304a\u3088\u30732\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u306b\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u3001\u4e21\u8005\u304c\u5171\u901a\u306e<\/strong>\u75c5\u56e0\u7d4c\u8def\uff08etiological pathway\uff09\u3092\u5171\u6709\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/strong><\/h2>\n\n\n\n<p>FTO\u907a\u4f1d\u5b50\uff08fat mass and obesity-associated gene\uff09\u306f\u67d3\u8272\u4f5316q12.2\u306b\u4f4d\u7f6e\u3057\u3001\u80a5\u6e80\u30ea\u30b9\u30af\u3068\u5f37\u304f\u95a2\u9023\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u6838\u9178\u8131\u30e1\u30c1\u30eb\u5316\uff08nucleic acid demethylation\uff09\u306b\u95a2\u4e0e\u3059\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u304a\u308a\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\uff08epigenetics\uff09\u2014\u3059\u306a\u308f\u3061DNA\u914d\u5217\u3092\u5909\u3048\u305a\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u4ed5\u7d44\u307f\u2014\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3712344_s.jpg\" alt=\"\u3082\u3050\u3082\u3050\" class=\"wp-image-11757\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3712344_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3712344_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u306a\u304b\u3067\u3082\u3001rs9939609\u3068\u3044\u3046SNP\u306f\u30a4\u30f3\u30c8\u30ed\u30f31\uff08intron 1\uff09\u5185\u306b\u4f4d\u7f6e\u3057\u3001BMI\u306e\u4e0a\u6607\u304a\u3088\u30732\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a4\u30f3\u30c8\u30ed\u30f3\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7ffb\u8a33\u3055\u308c\u306a\u3044\u975e\u30b3\u30fc\u30c9\u9818\u57df\u3067\u3059\u304c\u3001\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\uff08enhancer\uff09\u3084\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u5236\u5fa1\u9818\u57df\u306a\u3069\u306e\u8abf\u7bc0\u914d\u5217\u3092\u542b\u3080\u3053\u3068\u304c\u3042\u308a\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5927\u304d\u304f\u95a2\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306eSNP\u306f\u3001FTO\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f31\u304b\u3089\u30a8\u30af\u30bd\u30f32\u306b\u307e\u305f\u304c\u308b47\u30ad\u30ed\u30d9\u30fc\u30b9\uff08kb\uff09\u306e\u9818\u57df\u5185\u306b\u5b58\u5728\u3059\u308b10\u500b\u306e\u5f37\u304f\u9023\u9396\u3057\u305fSNP\u7fa4\uff08linkage disequilibrium block\uff09\u306e\u4e00\u90e8\u3067\u3042\u308a\u3001r\u00b2\u5024\uff080.52\u301c1.0\uff09\u304c\u9ad8\u3044\u3053\u3068\u304b\u3089\u3001\u3053\u308c\u3089\u306eSNP\u306f\u4e92\u3044\u306b\u5171\u907a\u4f1d\u3057\u3084\u3059\u3044\u72b6\u614b\u306b\u3042\u308a\u307e\u3059\u3002\u4e2d\u3067\u3082rs9939609\u306f\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\u6210\u529f\u7387\uff08genotyping success rate\uff09\u304c100%\u3068\u6700\u3082\u9ad8\u304f\u3001\u7814\u7a76\u5bfe\u8c61\u3068\u3057\u3066\u6709\u7528\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs9939609-hgtIdeo_genome_1a2f1c_f36f00-1024x25.png\" alt=\"rs9939609\" class=\"wp-image-11827\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs9939609-hgtIdeo_genome_1a2f1c_f36f00-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs9939609-hgtIdeo_genome_1a2f1c_f36f00-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs9939609-hgtIdeo_genome_1a2f1c_f36f00-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs9939609-hgtIdeo_genome_1a2f1c_f36f00.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>HapMap\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08\u56fd\u969b\u7684\u306a\u30d2\u30c8\u907a\u4f1d\u7684\u591a\u69d8\u6027\u30de\u30c3\u30d7\uff09\u306b\u3088\u308c\u3070\u3001rs9939609\u306eA\u30a2\u30ec\u30eb\uff08\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff09\u306e\u983b\u5ea6\u306f\u3001\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\uff08CEPH\uff09\u306745%\u3001\u30ca\u30a4\u30b8\u30a7\u30ea\u30a2\u7cfb\uff08Yoruban\uff09\u306752%\u3001\u4e00\u65b9\u3067\u6771\u30a2\u30b8\u30a2\u7cfb\uff08\u4e2d\u56fd\u4eba\u304a\u3088\u3073\u65e5\u672c\u4eba\uff09\u3067\u306f14%\u3068\u3001\u96c6\u56e3\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4812829_s.jpg\" alt=\"\u304a\u306a\u304b\" class=\"wp-image-11764\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4812829_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4812829_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u91cd\u5ea6\u80a5\u6e80\uff08BMI > 40 kg\/m\u00b2\uff09\u306e\u500b\u4f53\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b7\u30fc\u30af\u30a8\u30f3\u30b7\u30f3\u30b0\u7814\u7a76\u3067\u306f\u3001FTO\u907a\u4f1d\u5b50\u5185\u306b\u6a5f\u80fd\u7684\u306a\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u5909\u7570\uff08functional coding variants\uff09\u306f\u78ba\u8a8d\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u5909\u7570\u306e\u5f71\u97ff\u306f\u907a\u4f1d\u5b50\u5236\u5fa1\u9818\u57df\uff08regulatory variants\uff09\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002FTO\u306e\u8fd1\u508d\u306b\u306fKIAA1005\u907a\u4f1d\u5b50\uff08\u5225\u540dRPGRIP1L\uff09\u304c\u9006\u65b9\u5411\u306b\u8ee2\u5199\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u304cFTO\u9818\u57df\u306e\u8abf\u7bc0\u4f5c\u7528\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u660e\u78ba\u306a\u6a5f\u5e8f\u306f\u307e\u3060\u78ba\u5b9a\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001rs9939609\u306eA\u30a2\u30ec\u30eb\u304cBMI\u304a\u3088\u3073\u80a5\u6e80\u30ea\u30b9\u30af\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u4e00\u8cab\u6027\u306e\u3042\u308b\u518d\u73fe\u53ef\u80fd\u306a\u8a3c\u62e0\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u95a2\u9023\u306f7\u6b73\u9803\u304b\u3089\u691c\u51fa\u53ef\u80fd\u3067\u3042\u308a\u3001\u751f\u6daf\u306b\u308f\u305f\u3063\u3066\u4f53\u8102\u80aa\u91cf\uff08adiposity\uff09\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"715\" height=\"755\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9C0B1-F1-1.png\" alt=\"Alpha-ketoglutarate-dependent dioxygenase FTO\" class=\"wp-image-11834\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9C0B1-F1-1.png 715w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9C0B1-F1-1-284x300.png 284w\" sizes=\"(max-width: 715px) 100vw, 715px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>FTO\u306e\u52b9\u679c\u306f\u52a0\u7b97\u7684\uff08additive\uff09\u3067\u3042\u308a\u3001A\u30a2\u30ec\u30eb\u30921\u30b3\u30d4\u30fc\u6301\u3064\u3054\u3068\u306bBMI\u304c\u6bb5\u968e\u7684\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002FTO\u30682\u578b\u7cd6\u5c3f\u75c5\u3068\u306e\u95a2\u9023\u306fBMI\u3092\u4ecb\u3057\u3066\u5a92\u4ecb\u3055\u308c\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u8102\u80aa\u84c4\u7a4d\u3053\u305d\u304c\u7cd6\u5c3f\u75c5\u767a\u75c7\u306e\u4e2d\u5fc3\u7684\u306a\u8981\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u5f37\u8abf\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8eab\u4f53\u8a08\u6e2c\uff08anthropometry\uff09\u304a\u3088\u3073\u30c7\u30e5\u30a2\u30eb\u30a8\u30cd\u30eb\u30ae\u30fcX\u7dda\u5438\u53ce\u6cd5\uff08DEXA\uff1adual-energy X-ray absorptiometry\uff09\u306b\u3088\u308b\u89e3\u6790\u306e\u7d50\u679c\u3001A\u30a2\u30ec\u30eb\u306b\u3088\u308a\u5897\u52a0\u3059\u308b\u306e\u306f\u4e3b\u306b\u8102\u80aa\u91cf\uff08fat mass\uff09\u3067\u3042\u308a\u3001\u9664\u8102\u80aa\u91cf\uff08lean mass\uff09\u3084\u8eab\u9577\uff08height\uff09\u3001\u9aa8\u5bc6\u5ea6\uff08bone density\uff09\u306b\u306f\u5927\u304d\u306a\u5f71\u97ff\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4812811_s.jpg\" alt=\"\u304a\u3059\u308f\u308a\" class=\"wp-image-11785\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4812811_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4812811_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u96c6\u56e3\u69cb\u9020\uff08population stratification\uff09\u306b\u3088\u308b\u4ea4\u7d61\u304c\u306a\u3044\u3088\u3046\u53b3\u5bc6\u306b\u7ba1\u7406\u3055\u308c\u3066\u304a\u308a\u3001\u5206\u6790\u5bfe\u8c61\u306f\u3059\u3079\u3066\u767d\u4eba\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u96c6\u56e3\u3068\u3057\u3001\u5730\u57df\u5dee\u3084\u907a\u4f1d\u7684\u80cc\u666f\u306e\u504f\u308a\u3092\u4e3b\u6210\u5206\u5206\u6790\uff08principal component analysis\uff09\u3084\u5c45\u4f4f\u5730\u306b\u3088\u3063\u3066\u88dc\u6b63\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6b63\u78ba\u306a\u6a5f\u80fd\u7684\u5909\u7570\uff08functional variant\uff09\u3084\u5206\u5b50\u6a5f\u69cb\uff08biological mechanism\uff09\u306f\u672a\u89e3\u660e\u3067\u3059\u304c\u3001FTO\u9818\u57df\u306f\u4eca\u5f8c\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u7814\u7a76\uff08functional studies\uff09\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u6a19\u7684\u3068\u3055\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3084\u904e\u5270\u767a\u73fe\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u3088\u308a\u3001\u80a5\u6e80\u3068\u306e\u5206\u5b50\u7684\u306a\u7d50\u3073\u3064\u304d\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306e\u767a\u898b\u30d5\u30a7\u30fc\u30ba\u3067\u306f\u3001\u82f1\u56fd\u306eWellcome Trust Case Control Consortium\uff08WTCCC\uff09\u306b\u3088\u3063\u3066\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790\uff08GWAS\uff1agenome-wide association study\uff09\u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u89e3\u6790\u3067\u306f\u3001\u82f1\u56fd\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u80051924\u540d\u304a\u3088\u3073\u5bfe\u7167\u7fa42938\u540d\u3092\u5bfe\u8c61\u306b\u3001\u8a08490,032\u500b\u306e\u4e00\u5869\u57fa\u591a\u578b\uff08SNP\uff1asingle nucleotide polymorphism\uff09\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/330945_s.jpg\" alt=\"\u30d4\u30b6\u30fc\" class=\"wp-image-11778\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/330945_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/330945_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u767a\u898b\u7d50\u679c\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u30013757\u540d\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u304a\u3088\u30735346\u540d\u306e\u5bfe\u7167\u8005\u3092\u5bfe\u8c61\u306b\u3057\u305f\u8ffd\u8a66\uff08replication study\uff09\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u306e\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u89e3\u6790\u3067\u306f\u3001\u5e74\u9f6228\u301c74\u6b73\u3001\u5e73\u5747BMI\u304c22.7\u301c27.2\u3067\u3042\u308b\u6b27\u5dde\u6210\u4eba7\u30b3\u30db\u30fc\u30c8\uff08\u5408\u8a0819,424\u540d\uff09\u3068\u3001\u5e74\u9f627\u301c14\u6b73\u3001\u5e73\u5747BMI\u304c16.1\u301c19.2\u306e\u5c0f\u51502\u30b3\u30db\u30fc\u30c8\uff08\u5408\u8a0810,172\u540d\uff09\u304c\u5206\u6790\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\u306f\u3001FTO\u907a\u4f1d\u5b50\u5185\u306ers9939609\u3092\u4e2d\u5fc3\u306b\u884c\u308f\u308c\u3001\u7d71\u8a08\u89e3\u6790\u306b\u306f\u52a0\u7b97\u30e2\u30c7\u30eb\uff08additive model\uff09\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002\u5404\u30b3\u30db\u30fc\u30c8\u3067\u306eBMI\u5024\u3092\u6a19\u6e96\u5316\u3059\u308b\u305f\u3081\u3001Z\u30b9\u30b3\u30a2\u5909\u63db\u304c\u5b9f\u65bd\u3055\u308c\u3001\u3053\u308c\u306b\u3088\u308a\u7570\u306a\u308b\u5e74\u9f62\u5c64\u3084\u6e2c\u5b9a\u57fa\u6e96\u306e\u9055\u3044\u3092\u8abf\u6574\u3057\u3066\u3044\u307e\u3059\u3002\u5168\u4f53\u306e\u52b9\u679c\u63a8\u5b9a\u306b\u306f\u3001\u9006\u5206\u6563\u52a0\u91cd\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08inverse variance meta-analysis\uff09\u304a\u3088\u3073Mantel-Haenszel\u6cd5\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/28825513_s.jpg\" alt=\"\u3053\u3057\" class=\"wp-image-11799\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/28825513_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/28825513_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u8eab\u4f53\u7684\u8a55\u4fa1\u306b\u306f\u3001BMI\u306b\u52a0\u3048\u3001\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u9577\uff08waist circumference\uff09\u3001\u76ae\u4e0b\u8102\u80aa\u539a\uff08skinfold thickness\uff09\u3001\u304a\u3088\u3073DEXA\uff08dual-energy X-ray absorptiometry\uff09\u306b\u3088\u308b\u8102\u80aa\u91cf\u304a\u3088\u3073\u9664\u8102\u80aa\u91cf\u306e\u6e2c\u5b9a\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u591a\u91cd\u6bd4\u8f03\u306b\u3088\u308b\u507d\u967d\u6027\u3092\u9632\u3050\u305f\u3081\u306bBonferroni\u88dc\u6b63\u304c\u65bd\u3055\u308c\u3001\u7570\u8cea\u6027\uff08heterogeneity\uff09\u306e\u691c\u51fa\u306b\u306fI\u00b2\u7d71\u8a08\u91cf\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\uff08I\u00b2 = 0\uff05\u306f\u7570\u8cea\u6027\u304c\u306a\u3044\u3053\u3068\u3092\u793a\u3059\uff09\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001FTO\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u304c\u3069\u306e\u6642\u70b9\u304b\u3089\u73fe\u308c\u308b\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u82f1\u56fd\u306eAvon Longitudinal Study of Parents and Children\uff08ALSPAC\uff1b\u5bfe\u8c61\u80057477\u540d\uff09\u304a\u3088\u3073\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306eNorthern Finland 1966 Birth Cohort\uff08NFBC1966\uff1b\u5bfe\u8c61\u80054320\u540d\uff09\u306e2\u3064\u306e\u51fa\u751f\u30b3\u30db\u30fc\u30c8\u304c\u7528\u3044\u3089\u308c\u3001\u51fa\u751f\u6642\u4f53\u91cd\u3001BMI\u306e\u7d4c\u6642\u7684\u5909\u5316\u3001\u304a\u3088\u3073\u80a5\u6e80\u306e\u6709\u7121\u3092\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<p>\u3059\u3079\u3066\u306e\u6210\u4eba\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3001rs9939609\u306eA\u30a2\u30ec\u30eb\u306f\u4e00\u8cab\u3057\u3066BMI\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002A\u30a2\u30ec\u30eb1\u30b3\u30d4\u30fc\u3042\u305f\u308a\u306eBMI\u5897\u52a0\u91cf\u306f0.34\u301c0.46 kg\/m\u00b2\u3067\u3042\u308a\u3001\u7d71\u5408\u5e73\u5747\u306f\u7d040.4 kg\/m\u00b2\uff08Z\u30b9\u30b3\u30a2 = 0.10\u300195\uff05\u4fe1\u983c\u533a\u9593\uff1a0.08\u301c0.12\u3001P\u5024 = 2 \u00d7 10\u207b\u00b2\u2070\uff09\u3067\u3057\u305f\u3002AA\u578b\uff08A\u30a2\u30ec\u30eb\u306e\u30db\u30e2\u63a5\u5408\u4f53\uff09\u306e\u5272\u5408\u306f\u7d0416\uff05\u3067\u3042\u308a\u3001TT\u578b\uff08\u975e\u30ea\u30b9\u30af\u578b\uff09\u3068\u6bd4\u8f03\u3057\u3066\u4f53\u91cd\u304c\u5e73\u5747\u3067\u7d043 kg\u91cd\u304f\u3001\u80a5\u6e80\u306e\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09\u306f1.67\u500d\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1665384_s.jpg\" alt=\"\u304a\u3078\u305d\" class=\"wp-image-11806\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1665384_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1665384_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u30011\u30a2\u30ec\u30eb\u3042\u305f\u308a\u306e\u80a5\u6e80\u30ea\u30b9\u30af\u306e\u30aa\u30c3\u30ba\u6bd4\u306f1.31\uff0895\uff05CI\uff1a1.23\u20131.39\u3001P = 6 \u00d7 10\u207b\u00b9\u2076\uff09\u3001\u904e\u4f53\u91cd\uff08overweight\uff09\u306e\u30ea\u30b9\u30af\u306f1.18\uff0895\uff05CI\uff1a1.13\u20131.24\u3001P = 1 \u00d7 10\u207b\u00b9\u00b2\uff09\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u521d\u671f\u306e\u75c7\u4f8b\u5bfe\u7167\u30c7\u30fc\u30bf\u3092\u542b\u3081\u308b\u3068\u3001\u80a5\u6e80\u306eOR\u306f1.32\uff08P = 3 \u00d7 10\u207b\u00b2\u2076\uff09\u3001\u904e\u4f53\u91cd\u306f1.18\uff08P = 2 \u00d7 10\u207b\u00b9\u2077\uff09\u3068\u3001\u3055\u3089\u306b\u6709\u610f\u6027\u304c\u9ad8\u307e\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u5c0f\u5150\u306b\u304a\u3044\u3066\u3082\u3001A\u30a2\u30ec\u30eb\u306f7\u6b73\u6642\u70b9\u3067\u3059\u3067\u306bBMI\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u6642\u70b9\u3067\u306eZ\u30b9\u30b3\u30a2\u306f0.08\uff08P = 3 \u00d7 10\u207b\u2075\uff09\u300111\u6b73\u6642\u70b9\u3067\u306f0.12\uff08P = 7 \u00d7 10\u207b\u2079\uff09\u3067\u3042\u308a\u3001\u3044\u305a\u308c\u3082\u7d040.4 kg\/m\u00b2\u306b\u76f8\u5f53\u3057\u307e\u3059\u300211\u6b73\u6642\u306e\u80a5\u6e80\u30ea\u30b9\u30af\u306eOR\u306f1.35\uff0895\uff05CI\uff1a1.14\u20131.61\u3001P = 6 \u00d7 10\u207b\u2074\uff09\u3001\u904e\u4f53\u91cd\u306eOR\u306f1.27\uff0895\uff05CI\uff1a1.16\u20131.39\u3001P = 2 \u00d7 10\u207b\u2077\uff09\u3067\u3057\u305f\u3002\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306e\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u306f\u300114\u6b73\u6642\u70b9\u3067\u306eBMI\u5897\u52a0\u306f\u3084\u3084\u5c0f\u3055\u3044\u3082\u306e\u306e\u3001Z\u30b9\u30b3\u30a20.05\uff08P = 0.04\uff09\u3068\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1665525_s.jpg\" alt=\"\u3053\u308d\u3093\" class=\"wp-image-11813\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1665525_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1665525_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u8ffd\u52a0\u306e\u8eab\u4f53\u8a08\u6e2c\u30c7\u30fc\u30bf\u3067\u306f\u3001A\u30a2\u30ec\u30eb\u306f\u4f53\u91cd\uff08Z\u30b9\u30b3\u30a2 = 0.09\u3001P = 4 \u00d7 10\u207b\u00b9\u2077\uff09\u3001\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u9577\uff08Z\u30b9\u30b3\u30a2 = 0.08\u3001P = 4 \u00d7 10\u207b\u2079\uff09\u3001\u76ae\u4e0b\u8102\u80aa\u539a\uff08Z\u30b9\u30b3\u30a2 = 0.11\u3001P = 2 \u00d7 10\u207b\u2075\uff09\u306e\u5897\u52a0\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5c0f\u5150\u306b\u304a\u3051\u308bDEXA\u89e3\u6790\u3067\u306f\u3001\u4f53\u91cd\u5897\u52a0\u304c\u4e3b\u306b\u8102\u80aa\u91cf\u306e\u5897\u52a0\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u8102\u80aa\u91cf\u306eZ\u30b9\u30b3\u30a2\u5897\u52a0\uff1a+0.12\u3001P = 6 \u00d7 10\u207b\u00b9\u2070\uff09\u3002\u9664\u8102\u80aa\u91cf\u306e\u5897\u52a0\u306f\u308f\u305a\u304b\uff08+0.04\u3001P = 0.03\uff09\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/330986_s.jpg\" alt=\"\u304a\u3049\" class=\"wp-image-11771\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/330986_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/330986_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001FTO\u907a\u4f1d\u5b50\u5185\u306e\u4e00\u822c\u7684\u306a\u907a\u4f1d\u7684\u5909\u7570\u3067\u3042\u308brs9939609\u304c\u3001\u5c0f\u5150\u671f\u304b\u3089\u9ad8\u9f62\u671f\u306b\u308f\u305f\u308bBMI\u304a\u3088\u3073\u80a5\u6e80\u30ea\u30b9\u30af\u306b\u6709\u610f\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u660e\u78ba\u306b\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306eSNP\u306e\u5f71\u97ff\u306f\u4e3b\u306b\u8102\u80aa\u91cf\u306e\u5897\u52a0\u3092\u901a\u3058\u3066\u73fe\u308c\u3001\u8eab\u9577\u3084\u7b4b\u8089\u91cf\u306e\u5897\u52a0\u3068\u306f\u7121\u95a2\u4fc2\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u7684\u5909\u7570\u306fBMI\u5168\u4f53\u306e\u3070\u3089\u3064\u304d\u306e\u7d041\uff05\u3092\u8aac\u660e\u3057\u3001\u80a5\u6e80\u306b\u95a2\u3059\u308b\u96c6\u56e3\u5bc4\u4e0e\u30ea\u30b9\u30af\uff08population-attributable risk\uff09\u306f20.4\uff05\u3068\u7b97\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u516c\u8846\u885b\u751f\u30ec\u30d9\u30eb\u3067\u3082\u7121\u8996\u3067\u304d\u306a\u3044\u5f71\u97ff\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672a\u3060\u305d\u306e\u6b63\u78ba\u306a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4e0d\u660e\u3067\u3059\u304c\u3001FTO\u9818\u57df\u306b\u306f\u8102\u80aa\u84c4\u7a4d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u8abf\u7bc0\u7684\u907a\u4f1d\u5b50\u5909\u7570\uff08regulatory variants\uff09\u304c\u5b58\u5728\u3059\u308b\u3068\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u3001\u8abf\u7bc0\u30a8\u30ec\u30e1\u30f3\u30c8\u306e\u30de\u30c3\u30d4\u30f3\u30b0\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u6a5f\u80fd\u89e3\u6790\u306a\u3069\u304c\u6975\u3081\u3066\u91cd\u8981\u3068\u306a\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u80a5\u6e80\u306e\u6a19\u7684\u578b\u4ecb\u5165\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u80a5\u6e80, \u4f53\u683c\u6307\u6570\uff08BMI\uff09, \u4e00\u5869\u57fa\u591a\u578b, FTO\u907a\u4f1d\u5b50, rs9939609, \u5c0f\u5150\u80a5\u6e80, \u6210\u4eba\u80a5\u6e80, \u907a\u4f1d\u7684\u591a\u578b, \u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9, \u30c7\u30ad\u30b5\u30b9\u30ad\u30e3\u30f3, \u907a\u4f1d\u5b50\u95a2\u9023\u7814\u7a76, obesity, body mass index (BMI), single nucleotide polymorphism, FTO gene, rs9939609, childhood obesity, adult obesity, genetic polymorphism, meta-analysis, DEXA scan, genetic association study<\/sup><\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32029542_s.jpg\" alt=\"pochi\" class=\"wp-image-11435\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32029542_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32029542_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.1141634\">Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R., Elliott, K. S., Lango, H., Rayner, N. W., Shields, B., Harries, L. W., Barrett, J. C., Ellard, S., Groves, C. J., Knight, B., Patch, A. M., Ness, A. R., Ebrahim, S., Lawlor, D. A., \u2026 McCarthy, M. I. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.\u00a0<em>Science (New York, N.Y.)<\/em>,\u00a0<em>316<\/em>(5826), 889\u2013894. https:\/\/doi.org\/10.1126\/science.1141634<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u80a5\u6e80\u306f\u4e16\u754c\u7684\u306a\u5065\u5eb7\u5371\u6a5f\u3067\u3042\u308a\u30012\u578b\u7cd6\u5c3f\u75c5\uff08type 2 diabetes mellitus\uff09\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\uff08cardiovascular disease\uff09\u3001\u9ad8\u8840\u5727\uff08hypertension\uff09\u3001\u8133 [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":11736,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[321,329,326,314,327,324,320,328,325,217,331,225,318,316,317,315,313,322,330,319,323,59,36],"class_list":["post-11710","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-bmi","tag-body-mass-index","tag-fat-mass","tag-fto","tag-genetic-polymorphism","tag-obesity","tag-rs9939609","tag-single-nucleotide-polymorphism","tag-325","tag-217","tag-331","tag-225","tag-318","tag-316","tag-317","tag-315","tag-313","tag-322","tag-330","tag-319","tag-323","tag-59","tag-gene-testing"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=11710"}],"version-history":[{"count":5,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11710\/revisions"}],"predecessor-version":[{"id":11841,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11710\/revisions\/11841"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/11736"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=11710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=11710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=11710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}