{"id":11842,"date":"2025-04-04T02:36:30","date_gmt":"2025-04-04T02:36:30","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=11842"},"modified":"2025-04-04T08:53:04","modified_gmt":"2025-04-04T08:53:04","slug":"rs6983267","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/rs6983267\/","title":{"rendered":"\u304c\u3093\u306e\u30ea\u30b9\u30af\u306f\u907a\u4f1d\u5b50\u3067\u6c7a\u307e\u308b\uff1f\u8907\u6570\u306e\u304c\u3093\u3068\u95a2\u9023\u3059\u308b\u201crs6983267\u201d\u3068\u306f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u80cc\u666f\uff5cBackground<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff1aGenome-Wide Association Studies\uff09\u306b\u3088\u3063\u3066\u3001\u4e73\u304c\u3093\u3001\u524d\u7acb\u817a\u304c\u3093\u3001\u5927\u8178\u304c\u3093\u306a\u3069\u306e\u767a\u304c\u3093\u611f\u53d7\u6027\u306b\u95a2\u9023\u3059\u308b\u8907\u6570\u306e\u67d3\u8272\u4f53\u9818\u57df\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u9818\u57df\u306f\u3001\u304c\u3093\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u5171\u901a\u306e\u907a\u4f1d\u7684\u5909\u7570\uff08\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff09\u3092\u542b\u3093\u3067\u304a\u308a\u3001\u305d\u306e\u591a\u304f\u306f\u7279\u5b9a\u306e\u304c\u3093\u7a2e\u306b\u7279\u7570\u7684\u306a\u95a2\u9023\u3092\u793a\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs6983267-hgtIdeo_genome_1d0410_f3afb0-1024x25.png\" alt=\"rs6983267\" class=\"wp-image-11852\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6983267-hgtIdeo_genome_1d0410_f3afb0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6983267-hgtIdeo_genome_1d0410_f3afb0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6983267-hgtIdeo_genome_1d0410_f3afb0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6983267-hgtIdeo_genome_1d0410_f3afb0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u4f8b\u5916\u7684\u306b\u8907\u6570\u306e\u304c\u3093\u7a2e\u3068\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u9818\u57df\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u304c\u67d3\u8272\u4f538\u756a\u9577\u8155\u306e8q24\u9818\u57df\u3067\u3042\u308a\u3001\u3053\u3053\u306b\u4f4d\u7f6e\u3059\u308b\u4e00\u5869\u57fa\u591a\u578b\uff08SNP\uff1aSingle Nucleotide Polymorphism\uff09\u3067\u3042\u308brs6983267\u306f\u3001\u524d\u7acb\u817a\u304c\u3093\u304a\u3088\u3073\u5927\u8178\u304c\u3093\u306e\u4e21\u65b9\u3068\u72ec\u7acb\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u8907\u6570\u306e\u304c\u3093\u7a2e\u306b\u95a2\u4e0e\u3059\u308bSNP\u306f\u3001\u300c\u591a\u81d3\u5668\u611f\u53d7\u6027\u30de\u30fc\u30ab\u30fc\u300d\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"751\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo8-MfXTfDeCFUXXUDGZLIAAAYbb.png\" alt=\"chromo8\" class=\"wp-image-11894\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo8-MfXTfDeCFUXXUDGZLIAAAYbb.png 751w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo8-MfXTfDeCFUXXUDGZLIAAAYbb-300x200.png 300w\" sizes=\"(max-width: 751px) 100vw, 751px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u53ef\u80fd\u6027\u3092\u3055\u3089\u306b\u691c\u8a0e\u3059\u308b\u305f\u3081\u3001\u672c\u7814\u7a76\u3067\u306f\u30dd\u30fc\u30e9\u30f3\u30c9\u4eba\u96c6\u56e3\u306b\u304a\u3044\u3066\u300111\u7a2e\u985e\u306e\u4ee3\u8868\u7684\u306a\u304c\u3093\u306b\u7f79\u60a3\u3057\u305f7,665\u4eba\u306e\u60a3\u8005\u304a\u3088\u30731,910\u4eba\u306e\u5bfe\u7167\u8005\uff08\u304c\u3093\u65e2\u5f80\u306e\u306a\u3044\u8005\uff09\u3092\u5bfe\u8c61\u306b\u3001rs6983267\u306e\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\uff08\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\uff09\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u30dd\u30fc\u30e9\u30f3\u30c9\u306f\u907a\u4f1d\u7684\u5747\u8cea\u6027\u304c\u9ad8\u304f\u3001<em>BRCA1<\/em>\u3001<em>NBS1<\/em>\u3001<em>CHEK2<\/em>\u3068\u3044\u3063\u305f\u304c\u3093\u95a2\u9023\u907a\u4f1d\u5b50\u306b\u304a\u3051\u308b\u5275\u59cb\u8005\u5909\u7570\uff08founder mutation\uff09\u304c\u7279\u5b9a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u95a2\u9023\u89e3\u6790\u306b\u9069\u3057\u305f\u96c6\u56e3\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u7126\u70b9\u3092\u5f53\u3066\u305frs6983267\u306f\u3001\u67d3\u8272\u4f538q24.21\u306b\u4f4d\u7f6e\u3059\u308bSNP\u3067\u3042\u308a\u3001\u304c\u3093\u306e\u9818\u57df\u5897\u5e45\uff08gene amplification\uff09\u304c\u3057\u3070\u3057\u3070\u8a8d\u3081\u3089\u308c\u308b\u300c\u907a\u4f1d\u5b50\u5bc6\u5ea6\u306e\u4f4e\u3044\uff08gene-poor\uff09\u300d\u9818\u57df\u306b\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u9818\u57df\u306f\u7d0419\u30ad\u30ed\u5869\u57fa\uff08kb\uff09\u306e\u9577\u3055\u3092\u6301\u3061\u3001\u5f37\u3044\u9023\u9396\u4e0d\u5e73\u8861\uff08LD\uff1aLinkage Disequilibrium\uff09\u72b6\u614b\u306b\u3042\u308a\u3001\u8fd1\u63a5\u3059\u308bSNP\u304c\u4e00\u7dd2\u306b\u907a\u4f1d\u3055\u308c\u3084\u3059\u3044\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"670\" height=\"662\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q06416-F1.png\" alt=\"Putative POU domain, class 5, transcription factor 1B\" class=\"wp-image-11901\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q06416-F1.png 670w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q06416-F1-300x296.png 300w\" sizes=\"(max-width: 670px) 100vw, 670px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>rs6983267\u306e\u8fd1\u508d\u306b\u306f\u3001\u6a5f\u80fd\u4e0d\u660e\u306e\u7591\u4f3c\u907a\u4f1d\u5b50\u3067\u3042\u308b<em>POU5F1P1<\/em>\u3068\u3001\u7d30\u80de\u306e\u5897\u6b96\u3084\u816b\u760d\u5316\u306b\u6df1\u304f\u95a2\u308f\u308b\u65e2\u77e5\u306e\u764c\u539f\u907a\u4f1d\u5b50\uff08oncogene\uff09<em>MYC<\/em>\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<em>MYC<\/em>\u306f\u591a\u304f\u306e\u304c\u3093\u3067\u904e\u5270\u767a\u73fe\u3042\u308b\u3044\u306f\u5897\u5e45\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u304c\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306frs6983267\u306e\u907a\u4f1d\u5b50\u578b\u3068<em>MYC<\/em>\u3084<em>POU5F1P1<\/em>\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u3068\u306e\u9593\u306b\u76f4\u63a5\u7684\u306a\u76f8\u95a2\u95a2\u4fc2\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u5927\u8178\u304c\u3093\u7d44\u7e54\u3067\u306frs6983267\u5ea7\u4f4d\u306b\u304a\u3051\u308b\u5bfe\u7acb\u907a\u4f1d\u5b50\u306e\u4e0d\u5747\u8861\uff08allelic imbalance\uff09\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u816b\u760d\u5185\u3067\u306f\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u3067\u3042\u308bG\u30a2\u30ec\u30eb\u304c\u9078\u629e\u7684\u306b\u4fdd\u6301\u3055\u308c\u308b\u50be\u5411\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u540c\u9818\u57df\u304c\u4f53\u7d30\u80de\u5909\u7570\u306b\u3088\u308b\u304c\u3093\u9032\u5c55\u306b\u304a\u3051\u308b\u30bf\u30fc\u30b2\u30c3\u30c8\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001rs6983267\u306f\u76f4\u63a5\u7684\u306a\u539f\u56e0\u5909\u7570\u3067\u306f\u306a\u3044\u306b\u305b\u3088\u3001\u5b9f\u969b\u306e\u75be\u60a3\u539f\u56e0\u3068\u306a\u308b\u5909\u7570\u3068\u9023\u9396\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u3053\u306e\u9818\u57df\u306f\u304c\u3093\u306b\u304a\u3044\u3066\u67d3\u8272\u4f53\u518d\u69cb\u6210\uff08chromosomal rearrangement\uff09\u304c\u983b\u767a\u3059\u308b\u3053\u3068\u304b\u3089\u3001rs6983267\u304c\u67d3\u8272\u4f53\u4e0d\u5b89\u5b9a\u6027\uff08chromosomal instability\uff09\u3092\u4fc3\u3059\u8106\u5f31\u90e8\u4f4d\uff08fragile site\uff09\u3092\u793a\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"217\" height=\"313\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/7T1Z.png\" alt=\"Myc proto-oncogene protein\" class=\"wp-image-11915\" style=\"width:133px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/7T1Z.png 217w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/7T1Z-208x300.png 208w\" sizes=\"(max-width: 217px) 100vw, 217px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001rs6983267\u304c\u524d\u7acb\u817a\u304c\u3093\uff08\u30db\u30e2\u63a5\u5408\u578b\u306b\u304a\u3051\u308b\u30aa\u30c3\u30ba\u6bd4\uff3bOR\uff3d1.8\uff09\u304a\u3088\u3073\u5927\u8178\u304c\u3093\uff08\u540c OR = 1.4\uff09\u306e\u611f\u53d7\u6027\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3053\u3068\u3092\u3001\u3053\u308c\u307e\u3067\u306e\u5831\u544a\u3068\u540c\u69d8\u306b\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306eOR\u5024\u306f\u3001\u4ed6\u306e\u6c11\u65cf\u96c6\u56e3\u306b\u304a\u3051\u308b\u7814\u7a76\u3068\u4e00\u81f4\u3057\u3066\u304a\u308a\u3001\u3053\u306eSNP\u306e\u52b9\u679c\u304c\u4eba\u7a2e\u3092\u8d85\u3048\u3066\u4e00\u8cab\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4006480_s.jpg\" alt=\"\u304c\u3093\" class=\"wp-image-11922\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4006480_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4006480_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001rs6983267\u306f\u814e\u304c\u3093\uff08OR = 1.52\uff09\u3001\u7532\u72b6\u817a\u304c\u3093\uff08OR = 1.37\uff09\u3001\u5589\u982d\u304c\u3093\uff08OR = 1.39\uff09\u3068\u3082\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u3053\u306eSNP\u304c\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u306e\u3042\u308b\u304c\u3093\u7a2e\u304c\u5f93\u6765\u3088\u308a\u3082\u5e83\u7bc4\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u30893\u3064\u306e\u304c\u3093\u306b\u3064\u3044\u3066\u306f\u3001\u75c7\u4f8b\u6570\u304c\u5c11\u306a\u304b\u3063\u305f\u305f\u3081\u7d71\u8a08\u7684\u6709\u610f\u6027\u306f\u9650\u754c\u7684\u3067\u3057\u305f\u304c\u3001\u6709\u610f\u50be\u5411\u306f\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u4ed6\u306e\u304c\u3093\u7a2e\uff08\u4e73\u304c\u3093\u3001\u5375\u5de3\u304c\u3093\u3001\u8180\u80f1\u304c\u3093\u3001\u80c3\u304c\u3093\u3001\u80ba\u304c\u3093\u3001\u76ae\u819a\u304c\u3093\uff09\u3067\u306f\u7d71\u8a08\u7684\u306a\u6709\u610f\u6027\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u30db\u30e2\u63a5\u5408\u4f53\u306b\u304a\u3051\u308bOR\u306f\u3044\u305a\u308c\u30821.0\u3092\u4e0a\u56de\u3063\u3066\u304a\u308a\u3001\u5f31\u3044\u5f71\u97ff\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u306f\u5426\u5b9a\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u7279\u306b\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001\u5bb6\u65cf\u6b74\u3068\u306e\u95a2\u9023\u6027\u3067\u3059\u30028\u3064\u306e\u304c\u3093\u7a2e\u306b\u3064\u3044\u3066\u5bb6\u65cf\u6b74\u306e\u60c5\u5831\u304c\u5229\u7528\u53ef\u80fd\u3067\u3042\u308a\u3001\u305d\u306e\u3046\u30616\u7a2e\uff08\u524d\u7acb\u817a\u3001\u4e73\u623f\u3001\u8180\u80f1\u3001\u5589\u982d\u3001\u80ba\u3001\u76ae\u819a\uff09\u304c\u3093\u3067\u306f\u3001\u7b2c\u4e00\u5ea6\u8fd1\u89aa\u8005\u306b\u304c\u3093\u60a3\u8005\u304c\u3044\u308b\u30b1\u30fc\u30b9\u3067\u30db\u30e2\u63a5\u5408\u4f53\u306eOR\u304c\u9ad8\u304f\u306a\u308b\u50be\u5411\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u55ab\u7159\u3068\u95a2\u9023\u306e\u6df1\u3044\u304c\u3093\uff08\u8180\u80f1\u304c\u3093\u3001\u5589\u982d\u304c\u3093\u3001\u80ba\u304c\u3093\uff09\u306b\u304a\u3044\u3066\u306f\u3001\u3053\u306e\u5dee\u304c\u7279\u306b\u9855\u8457\u3067\u3057\u305f\u3002\u305f\u3068\u3048\u3070\u3001\u8180\u80f1\u304c\u3093\u3067\u306f\u5bb6\u65cf\u6b74\u3042\u308a\u306e\u30db\u30e2\u63a5\u5408\u4f53OR\u304c1.89\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u5bb6\u65cf\u6b74\u306a\u3057\u3067\u306f0.86\u306b\u3068\u3069\u307e\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1068745_s.jpg\" alt=\"\u308a\u307c\u3093\" class=\"wp-image-11929\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1068745_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1068745_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u524d\u7acb\u817a\u304c\u3093\u306e\u75c7\u4f8b\uff08n = 993\uff09\u306b\u304a\u3044\u3066\u3001\u816b\u760d\u306e\u60aa\u6027\u5ea6\u3092\u793a\u3059\u30b0\u30ea\u30fc\u30bd\u30f3\u30b9\u30b3\u30a2\uff08Gleason Score\uff09\u5225\u306b\u89e3\u6790\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u9ad8\u60aa\u6027\u5ea6\uff08\u30b9\u30b3\u30a28\u4ee5\u4e0a\uff09\u306e\u816b\u760d\u3067G\u30a2\u30ec\u30eb\u306eOR\u306f1.71\u3068\u3001\u4f4e\u301c\u4e2d\u7b49\u5ea6\uff08\u30b9\u30b3\u30a27\u4ee5\u4e0b\uff09\u306e\u816b\u760d\uff08OR = 1.32\uff09\u3088\u308a\u9ad8\u3044\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u3053\u306e\u5dee\u306f\u7d71\u8a08\u7684\u306b\u6709\u610f\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001rs6983267\u304c\u591a\u81d3\u5668\u306b\u304a\u3051\u308b\u767a\u304c\u3093\u611f\u53d7\u6027\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u3066\u3044\u307e\u3059\u3002\u3053\u306eSNP\u306e\u5f79\u5272\u306f\u3001\u67d3\u8272\u4f53\u4e0d\u5b89\u5b9a\u6027\u306e\u4fc3\u9032\u3001\u3042\u308b\u3044\u306f\u9060\u4f4d\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5236\u5fa1\u306a\u3069\u3001\u5e83\u6c4e\u306a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u901a\u3058\u305f\u3082\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30dd\u30fc\u30e9\u30f3\u30c9\u4eba\u96c6\u56e3\u304b\u3089\u53ce\u96c6\u3057\u305f11\u7a2e\u985e\u306e\u304c\u3093\u306b\u7f79\u60a3\u3057\u305f7,665\u4eba\u306e\u60a3\u8005\u3068\u3001\u304c\u3093\u65e2\u5f80\u306e\u306a\u30441,910\u4eba\u306e\u5bfe\u7167\u8005\u3092\u5bfe\u8c61\u306brs6983267\u306e\u907a\u4f1d\u5b50\u578b\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u304c\u3093\u60a3\u8005\u306e\u9078\u5b9a\u306f\u5e74\u9f62\u3084\u5bb6\u65cf\u6b74\u306b\u3088\u3089\u305a\u3001\u5168\u56fd\u306e\u75c5\u9662\u304b\u3089\u5e45\u5e83\u304f\u53ce\u96c6\u3055\u308c\u307e\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u53c2\u52a0\u8005\u306f\u6587\u66f8\u306b\u3088\u308b\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30fb\u30b3\u30f3\u30bb\u30f3\u30c8\u3092\u63d0\u4f9b\u3057\u3001\u672c\u7814\u7a76\u306f\u30dd\u30e1\u30e9\u30cb\u30a2\u533b\u79d1\u5927\u5b66\u306e\u502b\u7406\u5be9\u67fb\u59d4\u54e1\u4f1a\u306e\u627f\u8a8d\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg\" alt=\"\" class=\"wp-image-11365\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u304c\u3093\u75c7\u4f8b\u306e\u5185\u8a33\u3068\u5e73\u5747\u5e74\u9f62\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u524d\u7acb\u817a\u304c\u3093\uff1a1,885\u4f8b\uff08\u5e73\u5747\u5e74\u9f62 67.4\u6b73\uff09<\/li>\n\n\n\n<li>\u4e73\u304c\u3093\uff1a1,006\u4f8b\uff0856.4\u6b73\uff09<\/li>\n\n\n\n<li>\u5375\u5de3\u304c\u3093\uff1a618\u4f8b\uff0854.4\u6b73\uff09<\/li>\n\n\n\n<li>\u7d50\u8178\u304c\u3093\uff1a779\u4f8b\uff0863.4\u6b73\uff09<\/li>\n\n\n\n<li>\u814e\u304c\u3093\uff1a465\u4f8b\uff0857.5\u6b73\uff09<\/li>\n\n\n\n<li>\u8180\u80f1\u304c\u3093\uff1a303\u4f8b\uff0862.6\u6b73\uff09<\/li>\n\n\n\n<li>\u5589\u982d\u304c\u3093\uff1a400\u4f8b\uff0848.4\u6b73\uff09<\/li>\n\n\n\n<li>\u80ba\u304c\u3093\uff1a738\u4f8b\uff0861.4\u6b73\uff09<\/li>\n\n\n\n<li>\u60aa\u6027\u9ed2\u8272\u816b\uff08\u76ae\u819a\u304c\u3093\uff09\uff1a498\u4f8b\uff0853.4\u6b73\uff09<\/li>\n\n\n\n<li>\u80c3\u304c\u3093\uff1a488\u4f8b\uff0858.5\u6b73\uff09<\/li>\n\n\n\n<li>\u7532\u72b6\u817a\u304c\u3093\uff1a485\u4f8b\uff0848.4\u6b73\uff09<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u5bfe\u7167\u7fa4\u306f2\u3064\u306e\u7570\u306a\u308b\u96c6\u56e3\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u3044\u305a\u308c\u3082\u304c\u3093\u65e2\u5f80\u3092\u6301\u305f\u305a\u3001\u5bb6\u65cf\u6b74\u60c5\u5831\u3082\u53ce\u96c6\u3055\u308c\u307e\u3057\u305f\u3002DNA\u306f\u672b\u68a2\u8840\uff085\u301c10 cc\uff09\u304b\u3089\u62bd\u51fa\u3057\u3001\u5236\u9650\u9175\u7d20\u65ad\u7247\u9577\u591a\u578b\u6cd5\uff08RFLP-PCR\uff09\u3092\u7528\u3044\u3066rs6983267\u306e\u907a\u4f1d\u5b50\u578b\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u4f7f\u7528\u3057\u305f\u30d7\u30e9\u30a4\u30de\u30fc\u3068\u5236\u9650\u9175\u7d20\uff08NmuCI\uff09\u306f\u4fe1\u983c\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u7121\u4f5c\u70ba\u62bd\u51fa\u3055\u308c\u305f\u30b5\u30f3\u30d7\u30eb\u306e\u518d\u89e3\u6790\u306b\u3088\u308a99.5\u301c100\uff05\u306e\u4e00\u81f4\u7387\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32254140_s-1.jpg\" alt=\"\u767d\u8863\" class=\"wp-image-11943\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32254140_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32254140_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7d71\u8a08\u89e3\u6790\u306b\u306f2\u00d72\u306e\u5206\u5272\u8868\u306b\u57fa\u3065\u304f\u30aa\u30c3\u30ba\u6bd4\u306e\u7b97\u51fa\u3092\u884c\u3044\u3001\u30d5\u30a3\u30c3\u30b7\u30e3\u30fc\u306e\u6b63\u78ba\u78ba\u7387\u691c\u5b9a\u3067\u7d71\u8a08\u7684\u6709\u610f\u6027\u3092\u5224\u5b9a\u3057\u307e\u3057\u305f\uff08P\u5024&lt;0.05\uff09\u3002\u591a\u91cd\u691c\u5b9a\u88dc\u6b63\u306f\u884c\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u7d50\u679c\uff5cResults<\/strong><\/h2>\n\n\n\n<p>rs6983267\u306eG\u30a2\u30ec\u30eb\u306f\u3001\u4ee5\u4e0b\u306e5\u3064\u306e\u304c\u3093\u7a2e\u3067\u6709\u610f\u306b\u9ad8\u3044\u30aa\u30c3\u30ba\u6bd4\u3092\u793a\u3057\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u524d\u7acb\u817a\u304c\u3093\uff1aOR = 1.43\uff08P = 10\u207b\u2079\uff09<\/li>\n\n\n\n<li>\u7d50\u8178\u304c\u3093\uff1aOR = 1.13\uff08P = 0.01\uff09<\/li>\n\n\n\n<li>\u814e\u304c\u3093\uff1aOR = 1.43\uff08P = 0.007\uff09<\/li>\n\n\n\n<li>\u7532\u72b6\u817a\u304c\u3093\uff1aOR = 1.27\uff08P = 0.04\uff09<\/li>\n\n\n\n<li>\u5589\u982d\u304c\u3093\uff1aOR = 1.23\uff08P = 0.04\uff09<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"388\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32195582_s.jpg\" alt=\"\u304a\u306a\u304b\" class=\"wp-image-11950\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32195582_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32195582_s-300x182.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u80c3\u304c\u3093\u3092\u9664\u304f\u3059\u3079\u3066\u306e\u304c\u3093\u7a2e\u3067\u3001G\u30a2\u30ec\u30eb\u306e\u30db\u30e2\u63a5\u5408\u4f53\u306b\u304a\u3051\u308bOR\u304c\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u3088\u308a\u3082\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u4ed6\u306e\u304c\u3093\u7a2e\uff08\u4e73\u304c\u3093\u3001\u5375\u5de3\u304c\u3093\u3001\u8180\u80f1\u304c\u3093\u3001\u80c3\u304c\u3093\u3001\u80ba\u304c\u3093\u3001\u60aa\u6027\u9ed2\u8272\u816b\uff09\u306b\u304a\u3044\u3066\u3082\u3001\u30db\u30e2\u63a5\u5408\u4f53\u306eOR\u306f1.0\u3092\u4e0a\u56de\u3063\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u7d71\u8a08\u7684\u306a\u6709\u610f\u6027\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u5bb6\u65cf\u6b74\u306e\u5f71\u97ff\u306b\u95a2\u3059\u308b\u89e3\u6790\u3067\u306f\u30016\u3064\u306e\u304c\u3093\u7a2e\uff08\u524d\u7acb\u817a\u3001\u4e73\u623f\u3001\u8180\u80f1\u3001\u5589\u982d\u3001\u80ba\u3001\u76ae\u819a\uff09\u306b\u304a\u3044\u3066\u3001\u7b2c\u4e00\u5ea6\u8fd1\u89aa\u8005\u306b\u304c\u3093\u6b74\u306e\u3042\u308b\u75c7\u4f8b\u3067\u306f\u3001rs6983267\u30db\u30e2\u63a5\u5408\u4f53\u306eOR\u304c\u660e\u3089\u304b\u306b\u9ad8\u3044\u50be\u5411\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u55ab\u7159\u95a2\u9023\u304c\u3093\u3067\u306f\u5dee\u304c\u5927\u304d\u304f\u3001\u305f\u3068\u3048\u3070\u8180\u80f1\u304c\u3093\u3067\u306f\u5bb6\u65cf\u6b74\u3042\u308a\u3067\u306eOR\u304c1.89\u3001\u5bb6\u65cf\u6b74\u306a\u3057\u3067\u306eOR\u304c0.86\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23563732_s.jpg\" alt=\"\u5bb6\u65cf\" class=\"wp-image-11957\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23563732_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23563732_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7d50\u8ad6\uff5cConclusion<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001rs6983267\u304c\u8907\u6570\u306e\u304c\u3093\u7a2e\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u304f\u793a\u5506\u3059\u308b\u7d50\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u524d\u7acb\u817a\u304a\u3088\u3073\u7d50\u8178\u304c\u3093\u306b\u52a0\u3048\u3001\u814e\u304c\u3093\u3001\u7532\u72b6\u817a\u304c\u3093\u3001\u5589\u982d\u304c\u3093\u3068\u306e\u6709\u610f\u306a\u95a2\u9023\u6027\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u5404\u304c\u3093\u7a2e\u3067\u306e\u500b\u3005\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306f\u4e2d\u7b49\u5ea6\u3067\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u3053\u306eSNP\u306e\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08G\u30a2\u30ec\u30eb\uff09\u306e\u4fdd\u6709\u983b\u5ea6\u304c\u9ad8\u3044\u3053\u3068\uff08\u30dd\u30fc\u30e9\u30f3\u30c9\u96c6\u56e3\u3067\u7d0448%\uff09\u304b\u3089\u3001\u5168\u4f53\u3068\u3057\u3066\u306e\u516c\u8846\u885b\u751f\u4e0a\u306e\u5f71\u97ff\u306f\u7121\u8996\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31974029_s.jpg\" alt=\"\u306f\u30fc\u3068\" class=\"wp-image-11964\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31974029_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31974029_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u975e\u30b3\u30fc\u30c9\u9818\u57df\u306b\u4f4d\u7f6e\u3059\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001rs6983267\u306f\u816b\u760d\u751f\u7269\u5b66\u4e0a\u91cd\u8981\u306a<em>MYC<\/em>\u907a\u4f1d\u5b50\u8fd1\u508d\u306b\u5b58\u5728\u3057\u3001\u307e\u305f\u67d3\u8272\u4f538q\u306b\u304a\u3051\u308b\u518d\u69cb\u6210\u304c\u591a\u304f\u306e\u304c\u3093\u3067\u89b3\u5bdf\u3055\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u3053\u306eSNP\u304c\u67d3\u8272\u4f53\u4e0d\u5b89\u5b9a\u6027\u306e\u6307\u6a19\u307e\u305f\u306f\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5bb6\u65cf\u6b74\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3082\u8003\u616e\u3059\u308b\u3068\u3001rs6983267\u306f\u4e00\u822c\u7684\u306a\u304c\u3093\u30ea\u30b9\u30af\u3092\u793a\u3059\u6709\u7528\u306a\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u4eca\u5f8c\u306e\u6a5f\u80fd\u7684\u89e3\u6790\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/strong><\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>rs6983267, 8q24, \u764c\u611f\u53d7\u6027\uff08cancer susceptibility\uff09, \u524d\u7acb\u817a\u304c\u3093\uff08prostate cancer\uff09, \u7d50\u8178\u304c\u3093\uff08colon cancer\uff09, \u814e\u81d3\u304c\u3093\uff08kidney cancer\uff09, \u7532\u72b6\u817a\u304c\u3093\uff08thyroid cancer\uff09, \u5589\u982d\u304c\u3093\uff08laryngeal cancer\uff09, \u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08genome-wide association study\uff09, \u4e00\u5869\u57fa\u591a\u578b\uff08SNP, single nucleotide polymorphism\uff09, \u5bb6\u65cf\u6027\u304c\u3093\uff08familial cancer\uff09, \u67d3\u8272\u4f53\u4e0d\u5b89\u5b9a\u6027\uff08chromosomal instability\uff09<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32037717_s.jpg\" alt=\"\u3086\u3073\u3086\u3073\" class=\"wp-image-11971\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32037717_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32037717_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-1838\">Wokolorczyk, D., Gliniewicz, B., Sikorski, A., Zlowocka, E., Masojc, B., Debniak, T., Matyjasik, J., Mierzejewski, M., Medrek, K., Oszutowska, D., Suchy, J., Gronwald, J., Teodorczyk, U., Huzarski, T., Byrski, T., Jakubowska, A., G\u00f3rski, B., van de Wetering, T., Walczak, S., Narod, S. A., \u2026 Cybulski, C. (2008). A range of cancers is associated with the rs6983267 marker on chromosome 8.&nbsp;<em>Cancer research<\/em>,&nbsp;<em>68<\/em>(23), 9982\u20139986. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-1838<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco&nbsp;Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u8fd1\u5e74\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff1aGenome-Wide Association Studies\uff09\u306b\u3088\u3063\u3066\u3001\u4e73\u304c\u3093\u3001\u524d\u7acb\u817a\u304c\u3093\u3001\u5927\u8178\u304c\u3093\u306a\u3069\u306e\u767a\u304c\u3093\u611f\u53d7\u6027\u306b\u95a2\u9023\u3059\u308b\u8907\u6570\u306e\u67d3\u8272\u4f53\u9818\u57df\u304c\u660e\u3089\u304b [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":11887,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[340,262,332,242,336,16,349,338,249,225,335,348,334,343,344,339,341,333,345,337,36,342],"class_list":["post-11842","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-8q24","tag-gwas","tag-rs6983267","tag-snp","tag-336","tag-cancer_prevention","tag-349","tag-338","tag-249","tag-225","tag-335","tag-348","tag-334","tag-8q","tag-344","tag-339","tag-341","tag-333","tag-345","tag-337","tag-gene-testing","tag-342"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=11842"}],"version-history":[{"count":6,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11842\/revisions"}],"predecessor-version":[{"id":11982,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/11842\/revisions\/11982"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/11887"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=11842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=11842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=11842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}