{"id":12189,"date":"2025-04-04T06:46:50","date_gmt":"2025-04-04T06:46:50","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=12189"},"modified":"2025-04-04T08:53:03","modified_gmt":"2025-04-04T08:53:03","slug":"warriorworrier","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/warriorworrier\/","title":{"rendered":"\u300c\u6226\u58eb\u300d\u3068\u300c\u5fc3\u914d\u6027\u300d\u306f\u907a\u4f1d\u5b50\u3067\u6c7a\u307e\u308b\uff1fCOMT\u907a\u4f1d\u5b50\u304c\u5de6\u53f3\u3059\u308b\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3068\u611f\u60c5\u306e\u9055\u3044"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<p>\u4eba\u9593\u306e\u884c\u52d5\u306f\u3001\u907a\u4f1d\u7684\u7d20\u56e0\uff08genetic makeup\uff09\u3068\u795e\u7d4c\u751f\u7269\u5b66\u7684\u6a5f\u69cb\uff08neurobiological mechanisms\uff09\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u885d\u52d5\u6027\uff08impulsivity\uff09\u3001\u4e0d\u5b89\u50be\u5411\uff08anxiety\uff09\u3001\u8a8d\u77e5\u7684\u67d4\u8edf\u6027\uff08cognitive flexibility\uff09\u306a\u3069\u591a\u304f\u306e\u884c\u52d5\u7279\u6027\u306f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u304c\u3001\u8fd1\u5e74\u306e\u8a8d\u77e5\u795e\u7d4c\u79d1\u5b66\u304a\u3088\u3073\u907a\u4f1d\u5b66\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u795e\u7d4c\u56de\u8def\u306e\u6a5f\u80fd\u306b\u76f4\u63a5\u5f71\u97ff\u3092\u53ca\u307c\u3059\u907a\u4f1d\u5b50\u5909\u7570\uff08gene variants\uff09\u304c\u540c\u5b9a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5909\u7570\u306f\u3001\u611f\u60c5\u5236\u5fa1\u3001\u8a18\u61b6\u3001\u6ce8\u610f\u3001\u304a\u3088\u3073\u884c\u52d5\uff08behavior\uff09\u306b\u304a\u3051\u308b\u500b\u4eba\u5dee\u3092\u5f62\u4f5c\u308b\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/2786203_s.jpg\" alt=\"\u6226\u58eb\" class=\"wp-image-12217\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2786203_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2786203_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u305d\u306e\u4ee3\u8868\u4f8b\u304c\u3001\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u907a\u4f1d\u5b50\uff08catechol-O-methyltransferase gene\u3001\u7565\u79f0\uff1aCOMT\uff09\u3067\u3059\u3002COMT\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\uff08dopamine\uff09\u3092\u542b\u3080\u30ab\u30c6\u30b3\u30fc\u30eb\u30a2\u30df\u30f3\uff08catecholamines\uff09\u306e\u4ee3\u8b1d\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>COMT\u9175\u7d20\uff08COMT enzyme\uff09\u306f\u3001\u524d\u982d\u524d\u76ae\u8cea\uff08prefrontal cortex\u3001\u7565\u79f0\uff1aPFC\uff09\u306b\u304a\u3044\u3066\u7279\u306b\u91cd\u8981\u3067\u3059\u3002\u524d\u982d\u524d\u76ae\u8cea\u306f\u610f\u601d\u6c7a\u5b9a\u3001\u4f5c\u696d\u8a18\u61b6\u3001\u611f\u60c5\u5236\u5fa1\u306a\u3069\u306e\u5b9f\u884c\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u524d\u982d\u524d\u76ae\u8cea\u3067\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff08dopamine transporter\uff09\u306e\u5bc6\u5ea6\u304c\u4ed6\u306e\u8133\u9818\u57df\u3088\u308a\u3082\u4f4e\u3044\u305f\u3081\u3001COMT\u306b\u3088\u308b\u9175\u7d20\u5206\u89e3\u304c\u30c9\u30fc\u30d1\u30df\u30f3\u6fc3\u5ea6\u306e\u4e3b\u8981\u306a\u5236\u5fa1\u6a5f\u69cb\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u306b\u7531\u6765\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"687\" height=\"511\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P21964-F1.png\" alt=\"Catechol O-methyltransferase\" class=\"wp-image-12224\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P21964-F1.png 687w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P21964-F1-300x223.png 300w\" sizes=\"(max-width: 687px) 100vw, 687px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>COMT\u907a\u4f1d\u5b50\u306b\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u52b9\u7387\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u4e00\u5869\u57fa\u591a\u578b\uff08single nucleotide polymorphism\u3001\u7565\u79f0\uff1aSNP\uff09\u304c\u5b58\u5728\u3057\u3001\u3053\u306e\u907a\u4f1d\u7684\u5909\u7570\u304c\u8a8d\u77e5\u7684\u304a\u3088\u3073\u611f\u60c5\u7684\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u9055\u3044\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u9055\u3044\u306b\u57fa\u3065\u3044\u3066\u3001\u300c\u30ef\u30fc\u30ea\u30a2\u30fc\uff08\u6226\u58eb\u578b\u3001warrior\uff09\u300d\u5bfe\u300c\u30ef\u30fc\u30ea\u30a2\u30fc\uff08\u5fc3\u914d\u578b\u3001worrier\uff09\u300d\u3068\u3044\u3046\u6982\u5ff5\u30e2\u30c7\u30eb\u304c\u63d0\u5531\u3055\u308c\u3001\u907a\u4f1d\u7684\u7d20\u56e0\u306b\u57fa\u3065\u304f\u884c\u52d5\u7279\u6027\u306e\u7406\u89e3\u306b\u5f79\u7acb\u3066\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<p>COMT\u907a\u4f1d\u5b50\uff08catechol-O-methyltransferase gene\uff09\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\uff08dopamine\uff09\u3001\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\uff08epinephrine\uff09\u3001\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\uff08norepinephrine\uff09\u3068\u3044\u3063\u305f\u30ab\u30c6\u30b3\u30fc\u30eb\u30a2\u30df\u30f3\uff08catecholamines\uff09\u306b\u30e1\u30c1\u30eb\u57fa\u3092\u4ed8\u52a0\u3059\u308b\u3053\u3068\u3067\u305d\u308c\u3089\u3092\u4e0d\u6d3b\u6027\u5316\u3059\u308bCOMT\u9175\u7d20\uff08catechol-O-methyltransferase enzyme\uff09\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"755\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo4.png\" alt=\"chromo4\" class=\"wp-image-12240\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo4.png 755w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo4-300x199.png 300w\" sizes=\"(max-width: 755px) 100vw, 755px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u306b\u304a\u3051\u308b\u4ee3\u8868\u7684\u306a\u4e00\u5869\u57fa\u591a\u578b\uff08single nucleotide polymorphism\u3001\u7565\u79f0\uff1aSNP\uff09\u306f\u3001\u30b3\u30c9\u30f3158\uff08codon 158\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u53c2\u7167\u756a\u53f7\u3067\u306fcodon 108\uff09\u306b\u304a\u3051\u308b\u30b0\u30a2\u30cb\u30f3\uff08guanine\uff09\u304b\u3089\u30a2\u30c7\u30cb\u30f3\uff08adenine\uff09\u3078\u306e\u7f6e\u63db\u3067\u3042\u308a\u3001\u3053\u308c\u306b\u3088\u308a\u30a2\u30df\u30ce\u9178\u3067\u3042\u308b\u30d0\u30ea\u30f3\uff08valine\u3001Val\uff09\u304c\u30e1\u30c1\u30aa\u30cb\u30f3\uff08methionine\u3001Met\uff09\u306b\u7f6e\u304d\u63db\u308f\u308a\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u306f\u300cVal158Met\u300d\u307e\u305f\u306f\u300crs4680\u300d\u3068\u3057\u3066\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs4680-hgtIdeo_genome_3864d5_f79c70-1024x25.png\" alt=\"rs4680\" class=\"wp-image-12233\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs4680-hgtIdeo_genome_3864d5_f79c70-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs4680-hgtIdeo_genome_3864d5_f79c70-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs4680-hgtIdeo_genome_3864d5_f79c70-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs4680-hgtIdeo_genome_3864d5_f79c70.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u4e00\u5869\u57fa\u306e\u7f6e\u63db\u306fCOMT\u9175\u7d20\u306e\u6d3b\u6027\u3092\u5927\u304d\u304f\u5909\u5316\u3055\u305b\u307e\u3059\u3002Val158\u578b\uff08Val158 variant\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u9ad8\u6d3b\u6027\u578b\u306eCOMT\u3092\u6301\u3061\u3001\u7279\u306b\u524d\u982d\u524d\u76ae\u8cea\u306b\u304a\u3051\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u5206\u89e3\u304c\u901f\u304f\u9032\u307f\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u3053\u306e\u9818\u57df\u3067\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u57fa\u790e\u30ec\u30d9\u30eb\u306f\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001Met158\u578b\uff08Met158 variant\uff09\u3092\u6301\u3064\u4eba\u306f\u3001\u4f4e\u6d3b\u6027\u578b\u306eCOMT\u3092\u6301\u3061\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5206\u89e3\u304c\u9045\u3044\u305f\u3081\u3001\u524d\u982d\u524d\u76ae\u8cea\u3067\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u6fc3\u5ea6\u306f\u9ad8\u304f\u4fdd\u305f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31935910_s.jpg\" alt=\"\u30b9\u30c8\u30ec\u30b9\" class=\"wp-image-12248\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31935910_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31935910_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u795e\u7d4c\u5316\u5b66\u7684\u9055\u3044\u306f\u3001\u8a8d\u77e5\u6a5f\u80fd\u3084\u611f\u60c5\u53cd\u5fdc\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002Val158\u578b\u306e\u4eba\u3005\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\uff08stress resilience\uff09\u304c\u9ad8\u304f\u3001\u75db\u899a\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u4f4e\u3044\u50be\u5411\u304c\u3042\u308a\u3001\u3053\u308c\u306f\u300c\u6226\u58eb\uff08warrior\uff09\u300d\u578b\u8868\u73fe\u578b\uff08phenotype\uff09\u3068\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u6025\u5897\u304c\u3001\u5f7c\u3089\u306b\u3068\u3063\u3066\u6709\u76ca\u306b\u50cd\u304f\u3053\u3068\u306b\u8d77\u56e0\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001Met158\u578b\u306e\u4eba\u3005\u306f\u3001\u6301\u7d9a\u7684\u306a\u6ce8\u610f\u529b\u3084\u4f5c\u696d\u8a18\u61b6\u3092\u5fc5\u8981\u3068\u3059\u308b\u8ab2\u984c\u306b\u304a\u3044\u3066\u9ad8\u3044\u6210\u7e3e\u3092\u793a\u3059\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u540c\u6642\u306b\u4e0d\u5b89\u3084\u611f\u60c5\u7684\u904e\u53cd\u5fdc\u3092\u793a\u3057\u3084\u3059\u3044\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u9ad8\u3044\u57fa\u790e\u6fc3\u5ea6\u3068\u3001\u305d\u308c\u306b\u4f34\u3046\u8fba\u7e01\u7cfb\uff08limbic system\uff09\u306e\u6d3b\u6027\u5316\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31925610_s.jpg\" alt=\"\u30b9\u30c8\u30ec\u30b9\" class=\"wp-image-12255\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31925610_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31925610_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306e\u77e5\u898b\u306f\u3001COMT Val158Met\u591a\u578b\uff08Val158Met polymorphism\uff09\u304c\u3001\u524d\u982d\u524d\u76ae\u8cea\u306b\u304a\u3051\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u4ee3\u8b1d\u3092\u901a\u3058\u3066\u3001\u500b\u4eba\u306e\u8a8d\u77e5\u3001\u611f\u60c5\u3001\u304a\u3088\u3073\u884c\u52d5\u306e\u9055\u3044\u3092\u5f62\u6210\u3059\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u518d\u78ba\u8a8d\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u300c\u6226\u58eb\u578b\uff08warrior\uff09\u300d\u3068\u300c\u5fc3\u914d\u578b\uff08worrier\uff09\u300d\u3068\u3044\u3046\u67a0\u7d44\u307f\u306f\u3001\u9032\u5316\u8ad6\u7684\u8996\u70b9\u304b\u3089\u898b\u3066\u3082\u8aac\u5f97\u529b\u304c\u3042\u308a\u3001\u306a\u305c\u4e21\u65b9\u306e\u30a2\u30ec\u30eb\uff08alleles\uff09\u304c\u4eba\u985e\u96c6\u56e3\u306b\u5171\u5b58\u3057\u7d9a\u3051\u3066\u3044\u308b\u306e\u304b\u3092\u8aac\u660e\u3059\u308b\u3046\u3048\u3067\u6709\u7528\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/26483860_s.jpg\" alt=\"\u304a\u3061\u3083\" class=\"wp-image-12262\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/26483860_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/26483860_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Val158\u578b\u306e\u9ad8\u6d3b\u6027\u30a2\u30ec\u30eb\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u306e\u591a\u3044\u74b0\u5883\u3084\u5371\u6a5f\u7684\u72b6\u6cc1\u306b\u304a\u3044\u3066\u8fc5\u901f\u306a\u610f\u601d\u6c7a\u5b9a\u3084\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u5fc5\u8981\u3068\u3059\u308b\u5834\u9762\u3067\u9069\u5fdc\u7684\u5229\u70b9\u3092\u6301\u3061\u307e\u3059\u3002\u4e00\u65b9\u3001Met158\u578b\u306e\u4f4e\u6d3b\u6027\u30a2\u30ec\u30eb\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u304c\u5c11\u306a\u304f\u3001\u6ce8\u610f\u3084\u8a18\u61b6\u306e\u7cbe\u5bc6\u3055\u304c\u6c42\u3081\u3089\u308c\u308b\u72b6\u6cc1\u306b\u304a\u3044\u3066\u6709\u5229\u306b\u50cd\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u9032\u5316\u7684\u30d0\u30e9\u30f3\u30b9\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u6a5f\u80fd\u306e\u300c\u9006U\u5b57\u30e2\u30c7\u30eb\uff08inverted-U model of dopamine function\uff09\u300d\u306b\u3088\u308a\u652f\u6301\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u30e2\u30c7\u30eb\u3067\u306f\u3001\u8a8d\u77e5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u6fc3\u5ea6\u304c\u5897\u52a0\u3059\u308b\u306b\u3064\u308c\u3066\u5411\u4e0a\u3057\u307e\u3059\u304c\u3001\u3042\u308b\u95be\u5024\u3092\u8d85\u3048\u308b\u3068\u9006\u306b\u4f4e\u4e0b\u3057\u307e\u3059\u3002Val158\u578b\u306e\u4eba\u306f\u3001\u57fa\u790e\u7684\u306a\u30c9\u30fc\u30d1\u30df\u30f3\u6fc3\u5ea6\u304c\u4f4e\u3044\u305f\u3081\u3001\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u306b\u3088\u308a\u30c9\u30fc\u30d1\u30df\u30f3\u304c\u4e0a\u6607\u3059\u308b\u3068\u3001\u9006U\u5b57\u66f2\u7dda\u306e\u6700\u9069\u57df\u306b\u8fd1\u3065\u304d\u3001\u8a8d\u77e5\u6a5f\u80fd\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001Met158\u578b\u306e\u4eba\u306f\u3059\u3067\u306b\u6700\u9069\u57df\u306b\u8fd1\u3044\u305f\u3081\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u306e\u5897\u52a0\u304c\u904e\u5270\u3068\u306a\u308a\u3001\u304b\u3048\u3063\u3066\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31243182_s-1.jpg\" alt=\"\u5931\u8abf\u75c7\" class=\"wp-image-12269\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31243182_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31243182_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001COMT\u591a\u578b\u306f\u7cbe\u795e\u75be\u60a3\uff08psychiatric vulnerability\uff09\u3068\u306e\u95a2\u9023\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002Val158\u578b\u306f\u3001\u601d\u6625\u671f\u306b\u5927\u9ebb\uff08cannabis\uff09\u3092\u4f7f\u7528\u3057\u305f\u5834\u5408\u306b\u7d71\u5408\u5931\u8abf\u75c7\uff08schizophrenia\uff09\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001Met158\u578b\u306f\u3001\u4e0d\u5b89\u50be\u5411\u3084\u75db\u899a\u904e\u654f\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u3053\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u306f\u7814\u7a76\u306b\u3088\u308a\u7d50\u679c\u304c\u7570\u306a\u308a\u3001\u7279\u306b\u7d71\u5408\u5931\u8abf\u75c7\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u4e00\u8cab\u3057\u305f\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u4e00\u5375\u6027\u53cc\u751f\u5150\uff08monozygotic twins\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u7814\u7a76\uff08epigenetic studies\uff09\u3067\u306f\u3001COMT\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308b\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\uff08methylation patterns\uff09\u306b\u9055\u3044\u304c\u898b\u3089\u308c\u3001\u3053\u308c\u304c\u74b0\u5883\u8981\u56e0\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u907a\u4f1d\u5b50\u578b\uff08genotype\uff1a\u907a\u4f1d\u5b50\u914d\u5217\uff09\u3001\u30a8\u30d4\u30b8\u30a7\u30ce\u30bf\u30a4\u30d7\uff08epigenotype\uff1a\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5316\u5b66\u7684\u8abf\u7bc0\uff09\u3001\u305d\u3057\u3066\u8868\u73fe\u578b\uff08phenotype\uff1a\u89b3\u5bdf\u53ef\u80fd\u306a\u6027\u8cea\uff09\u306e\u9593\u306b\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3021992_s.jpg\" alt=\"\u53cc\u5b50\" class=\"wp-image-12276\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3021992_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3021992_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u89e3\u6790\u3001\u8a8d\u77e5\u6a5f\u80fd\u691c\u67fb\u3001\u6a5f\u80fd\u7684\u795e\u7d4c\u753b\u50cf\u6cd5\u3001\u304a\u3088\u3073\u81e8\u5e8a\u89b3\u5bdf\u3092\u7d71\u5408\u3057\u305f\u5b66\u969b\u7684\u7814\u7a76\u624b\u6cd5\u304c\u63a1\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u53c2\u52a0\u8005\u306f\u3001COMT Val158Met\u4e00\u5869\u57fa\u591a\u578b\u306b\u3064\u3044\u3066\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\u3092\u53d7\u3051\u3001\u5404\u4eba\u306e\u9175\u7d20\u6d3b\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968180_s.jpg\" alt=\"MRI\" class=\"wp-image-12284\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968180_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968180_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u8133\u6d3b\u52d5\u306e\u8a55\u4fa1\u306b\u306f\u3001\u6a5f\u80fd\u7684\u78c1\u6c17\u5171\u9cf4\u753b\u50cf\u6cd5\uff08functional magnetic resonance imaging\u3001\u7565\u79f0\uff1afMRI\uff09\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002fMRI\u306f\u3001\u795e\u7d4c\u6d3b\u52d5\u306e\u4ee3\u66ff\u6307\u6a19\u3068\u3057\u3066\u8840\u4e2d\u9178\u7d20\u6fc3\u5ea6\u4f9d\u5b58\u4fe1\u53f7\uff08blood-oxygen-level-dependent signal\u3001\u7565\u79f0\uff1aBOLD\u4fe1\u53f7\uff09\u3092\u6e2c\u5b9a\u3059\u308b\u624b\u6cd5\u3067\u3059\u3002\u611f\u60c5\u7684\u304a\u3088\u3073\u8a8d\u77e5\u7684\u8ab2\u984c\u4e2d\u306e\u8133\u9818\u57df\u306e\u6d3b\u6027\u5316\u304c\u3053\u306e\u65b9\u6cd5\u3067\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u8ab2\u984c\u5185\u5bb9\u306b\u306f\u3001\u6ce8\u610f\u306e\u8ee2\u63db\u3092\u8a55\u4fa1\u3059\u308b\u8996\u899a\u30aa\u30c3\u30c9\u30dc\u30fc\u30eb\u30d1\u30e9\u30c0\u30a4\u30e0\u3001\u75db\u899a\u53cd\u5fdc\u306e\u8a55\u4fa1\u3001\u4f5c\u696d\u8a18\u61b6\u8ab2\u984c\u306a\u3069\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u578b\u3054\u3068\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u9055\u3044\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u76ee\u7684\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23844389_s.jpg\" alt=\"\u672c\" class=\"wp-image-12293\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23844389_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23844389_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u4e00\u90e8\u306e\u53c2\u52a0\u8005\u306b\u306f\u30a2\u30f3\u30d5\u30a7\u30bf\u30df\u30f3\uff08amphetamine\uff09\u306a\u3069\u306e\u85ac\u7406\u5b66\u7684\u4ecb\u5165\u304c\u884c\u308f\u308c\u3001\u907a\u4f1d\u5b50\u578b\u306b\u4f9d\u5b58\u3057\u305f\u30c9\u30fc\u30d1\u30df\u30f3\u30b7\u30b0\u30ca\u30eb\u304a\u3088\u3073\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u304c\u8abf\u67fb\u3055\u308c\u307e\u3057\u305f\u3002\u30a2\u30f3\u30d5\u30a7\u30bf\u30df\u30f3\u306f\u30b7\u30ca\u30d7\u30b9\u9593\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u4f5c\u7528\u304c\u3042\u308a\u3001\u8ab2\u984c\u9042\u884c\u6210\u7e3e\u3084\u524d\u982d\u524d\u76ae\u8cea\u306e\u6d3b\u6027\u5909\u5316\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u305d\u306e\u5f71\u97ff\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u52a0\u3048\u3066\u3001COMT\u306e\u907a\u4f1d\u7684\u5909\u7570\u304c\u884c\u52d5\u306b\u3069\u306e\u3088\u3046\u306b\u73fe\u308c\u308b\u304b\u3092\u793a\u3059\u305f\u3081\u3001\u4e8b\u4f8b\u7d39\u4ecb\u3082\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305f\u3068\u3048\u3070\u3001\u540c\u3058\u5bb6\u5ead\u74b0\u5883\u3067\u80b2\u3063\u305f\u4e8c\u5375\u6027\u53cc\u751f\u5150\u306e\u4e00\u65b9\u306f\u30b9\u30ea\u30eb\u3092\u8ffd\u3044\u6c42\u3081\u308b\u885d\u52d5\u7684\u306a\u6027\u683c\u3001\u3082\u3046\u4e00\u65b9\u306f\u614e\u91cd\u3067\u5185\u7701\u7684\u306a\u6027\u683c\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u9055\u3044\u304c\u300c\u6226\u58eb\u578b\u300d\u3068\u300c\u5fc3\u914d\u578b\u300d\u306e\u67a0\u7d44\u307f\u306b\u4e00\u81f4\u3057\u3066\u3044\u305f\u3053\u3068\u304c\u7d39\u4ecb\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31944675_s.jpg\" alt=\"\u7768\u3093\u3067\u308b\u5973\u6027\" class=\"wp-image-11499\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31944675_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31944675_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<p>fMRI\u3092\u7528\u3044\u305f\u795e\u7d4c\u753b\u50cf\u89e3\u6790\u3067\u306f\u3001Val158\u578b\uff08Val158 carriers\uff09\u306e\u88ab\u9a13\u8005\u306b\u304a\u3044\u3066\u3001\u80cc\u5916\u5074\u524d\u982d\u524d\u76ae\u8cea\uff08dorsolateral prefrontal cortex\u3001\u7565\u79f0\uff1adlPFC\uff09\u3001\u524d\u5e2f\u72b6\u76ae\u8cea\uff08anterior cingulate cortex\u3001\u7565\u79f0\uff1aACC\uff09\u3001\u304a\u3088\u3073\u88dc\u8db3\u904b\u52d5\u91ce\uff08supplementary motor area\u3001\u7565\u79f0\uff1aSMA\uff09\u3068\u3044\u3063\u305f\u9818\u57df\u306b\u304a\u3051\u308bBOLD\u4fe1\u53f7\u306e\u632f\u5e45\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u524d\u982d\u524d\u76ae\u8cea\u3067\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u6fc3\u5ea6\u304c\u4f4e\u3044\u305f\u3081\u3001\u8a8d\u77e5\u5236\u5fa1\u56de\u8def\uff08cognitive control circuits\uff09\u306e\u52d5\u54e1\u304c\u52b9\u7387\u7684\u306b\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/335065_s.jpg\" alt=\"\u3053\u3076\u3057\" class=\"wp-image-12300\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/335065_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/335065_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u74b0\u5883\u3084\u85ac\u7406\u5b66\u7684\u523a\u6fc0\uff08\u305f\u3068\u3048\u3070\u30a2\u30f3\u30d5\u30a7\u30bf\u30df\u30f3\uff09\u4e0b\u3067\u306f\u3001Val158\u578b\u306e\u88ab\u9a13\u8005\u306b\u304a\u3044\u3066\u8a8d\u77e5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u5411\u4e0a\u3057\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u7cfb\u306e\u67d4\u8edf\u306a\u5fdc\u7b54\u6027\uff08flexible dopaminergic system\uff09\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/29244367_s.jpg\" alt=\"\u304b\u305f\" class=\"wp-image-12307\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29244367_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29244367_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e00\u65b9\u3001Met158\u578b\uff08Met158 carriers\uff09\u306e\u88ab\u9a13\u8005\u3067\u306f\u3001\u5acc\u60aa\u523a\u6fc0\u3078\u306e\u53cd\u5fdc\u3068\u3057\u3066\u3001\u6241\u6843\u4f53\uff08amygdala\uff09\u3084\u6d77\u99ac\uff08hippocampus\uff09\u306a\u3069\u306e\u8fba\u7e01\u7cfb\u69cb\u9020\uff08limbic structures\uff09\u306b\u304a\u3044\u3066\u9ad8\u3044\u57fa\u790e\u7684\u6d3b\u6027\u5316\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u53cd\u5fdc\u306e\u5f37\u3055\u306fMet\u30a2\u30ec\u30eb\u306e\u4fdd\u6709\u6570\u3068\u6b63\u306e\u76f8\u95a2\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u611f\u60c5\u53cd\u5fdc\u6027\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u306e\u7528\u91cf\u4f9d\u5b58\u7684\u52b9\u679c\uff08dose-dependent effect\uff09\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306eMet158\u578b\u306e\u88ab\u9a13\u8005\u306f\u3001\u975e\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u4e0b\u3067\u306f\u8a18\u61b6\u8ab2\u984c\u3084\u6ce8\u610f\u5236\u5fa1\u8ab2\u984c\u306b\u304a\u3044\u3066Val158\u578b\u3088\u308a\u3082\u9ad8\u3044\u6210\u7e3e\u3092\u793a\u3057\u307e\u3057\u305f\u304c\u3001\u30b9\u30c8\u30ec\u30b9\u8ca0\u8377\u304c\u52a0\u308f\u308b\u3068\u6210\u7e3e\u304c\u4f4e\u4e0b\u3059\u308b\u50be\u5411\u306b\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31397209_s.jpg\" alt=\"\u30b9\u30c8\u30ec\u30b9\" class=\"wp-image-12314\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u85ac\u7406\u907a\u4f1d\u5b66\u7684\u89e3\u6790\uff08pharmacogenetic findings\uff09\u3082\u9006U\u5b57\u30e2\u30c7\u30eb\u3092\u652f\u6301\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u30a2\u30f3\u30d5\u30a7\u30bf\u30df\u30f3\u6295\u4e0e\u5f8c\u3001Val158\u578b\u3067\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u30ec\u30d9\u30eb\u304c\u6700\u9069\u5024\u306b\u9054\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8a8d\u77e5\u6a5f\u80fd\u304c\u6539\u5584\u3055\u308c\u305f\u4e00\u65b9\u3001Met158\u578b\u3067\u306f\u904e\u5270\u306a\u30c9\u30fc\u30d1\u30df\u30f3\u6fc3\u5ea6\u306b\u3088\u308a\u8a8d\u77e5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u9006\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u30c9\u30fc\u30d1\u30df\u30f3\u904e\u98fd\u548c\u72b6\u614b\uff08dopaminergic oversaturation\uff09\u304c\u8a8d\u77e5\u6a5f\u80fd\u306e\u300c\u4e0b\u964d\u66f2\u7dda\u300d\u306b\u4f4d\u7f6e\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u601d\u6625\u671f\u306b\u5927\u9ebb\u3092\u4f7f\u7528\u3057\u305fVal158\u578b\u306e\u88ab\u9a13\u8005\u306f\u3001\u7d71\u5408\u5931\u8abf\u75c7\u69d8\u75c7\u72b6\uff08schizophrenia-like symptoms\uff09\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u907a\u4f1d\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u3068\u306e\u76f8\u4e92\u4f5c\u7528\uff08gene-environment interaction\uff09\u3092\u793a\u3059\u4e00\u4f8b\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/25470022_s.jpg\" alt=\"\u843d\u3061\u8fbc\u3093\u3060\" class=\"wp-image-12321\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25470022_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25470022_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u4e00\u5375\u6027\u53cc\u751f\u5150\u306b\u304a\u3051\u308bCOMT\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\uff08promoter sites\uff09\u306b\u304a\u3044\u3066\u3001\u30e1\u30c1\u30eb\u5316\uff08methylation\uff09\u30d1\u30bf\u30fc\u30f3\u306e\u5dee\u7570\u304c\u5831\u544a\u3055\u308c\u3001\u7cbe\u795e\u75be\u60a3\u611f\u53d7\u6027\uff08psychiatric susceptibility\uff09\u306e\u5f62\u6210\u306b\u304a\u3044\u3066\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u4fee\u98fe\uff08epigenetic modulation\uff09\u304c\u679c\u305f\u3059\u5f79\u5272\u304c\u5f37\u8abf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<p>\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bcVal158Met\u591a\u578b\u306f\u3001\u4e00\u5869\u57fa\u306e\u5909\u7570\u304c\u3001\u9175\u7d20\u6d3b\u6027\u3001\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u6fc3\u5ea6\u3001\u8133\u6d3b\u52d5\u30d1\u30bf\u30fc\u30f3\u3001\u8a8d\u77e5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3001\u304a\u3088\u3073\u7cbe\u795e\u7684\u8106\u5f31\u6027\u306b\u307e\u3067\u5e83\u7bc4\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3046\u308b\u3053\u3068\u3092\u793a\u3059\u5178\u578b\u7684\u306a\u4f8b\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"687\" height=\"511\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P21964-F1-1.png\" alt=\"Catechol O-methyltransferase\" class=\"wp-image-12328\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P21964-F1-1.png 687w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P21964-F1-1-300x223.png 300w\" sizes=\"(max-width: 687px) 100vw, 687px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3082\u3061\u308d\u3093\u30011\u3064\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3060\u3051\u3067\u4eba\u9593\u306e\u884c\u52d5\u3084\u7cbe\u795e\u75be\u60a3\u306e\u8907\u96d1\u6027\u3059\u3079\u3066\u3092\u8aac\u660e\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001COMT\uff08catechol-O-methyltransferase\uff09\u3068\u3044\u3046\u5206\u5b50\u306f\u3001\u611f\u60c5\u7684\u304a\u3088\u3073\u8a8d\u77e5\u7684\u6a5f\u80fd\u306b\u304a\u3051\u308b\u500b\u4eba\u5dee\u306e\u795e\u7d4c\u751f\u7269\u5b66\u7684\u57fa\u76e4\uff08neurobiological basis of individual differences\uff09\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u3001\u975e\u5e38\u306b\u826f\u304f\u7279\u6027\u304c\u89e3\u660e\u3055\u308c\u305f\u624b\u304c\u304b\u308a\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u300c\u6226\u58eb\u578b\uff08warrior\uff09\u300d\u3068\u300c\u5fc3\u914d\u578b\uff08worrier\uff09\u300d\u3068\u3044\u3046\u6bd4\u55a9\u306f\u3001Val158\u578b\uff08Val158 allele\uff09\u3092\u6301\u3064\u4eba\u3005\u304c\u3001\u5373\u5fdc\u7684\u3067\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u304c\u6c42\u3081\u3089\u308c\u308b\u74b0\u5883\u306b\u3088\u308a\u9069\u3057\u3066\u3044\u308b\u4e00\u65b9\u3001Met158\u578b\uff08Met158 allele\uff09\u3092\u6301\u3064\u4eba\u3005\u306f\u3001\u6ce8\u610f\u529b\u3084\u4f5c\u696d\u8a18\u61b6\u3068\u3044\u3063\u305f\u6301\u7d9a\u7684\u306a\u8a8d\u77e5\u52aa\u529b\u304c\u5fc5\u8981\u3068\u3055\u308c\u308b\u72b6\u6cc1\u306b\u304a\u3044\u3066\u9ad8\u3044\u80fd\u529b\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u3092\u7aef\u7684\u306b\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/25769582_s.jpg\" alt=\"gannbatteirukodomo\" class=\"wp-image-12335\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25769582_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25769582_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e21\u30a2\u30ec\u30eb\u304c\u4eba\u985e\u96c6\u56e3\u306b\u5171\u5b58\u3057\u7d9a\u3051\u3066\u3044\u308b\u3053\u3068\u306f\u3001\u305d\u308c\u305e\u308c\u306e\u884c\u52d5\u6226\u7565\u306b\u9032\u5316\u7684\u5229\u70b9\u304c\u5b58\u5728\u3057\u3001\u305d\u308c\u304c\u74b0\u5883\u306e\u8981\u6c42\u306b\u5fdc\u3058\u3066\u767a\u63ee\u3055\u308c\u3066\u304d\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3053\u306e\u3088\u3046\u306a\u5358\u7d14\u306a\u4e8c\u9805\u5bfe\u7acb\u7684\u30e2\u30c7\u30eb\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u8996\u70b9\u3082\u63d0\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u5065\u5eb7\u306a\u4e2d\u56fd\u4eba\u5927\u5b66\u751f\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u306f\u3001COMT rs4680\u591a\u578b\u306b\u304a\u3044\u3066Val\u30a2\u30ec\u30eb\u304c\u3001\u4f5c\u696d\u8a18\u61b6\uff08working memory\uff09\u80fd\u529b\u306e\u9ad8\u3055\u3084\u6d77\u99ac\u4f53\u7a4d\uff08hippocampal volume\uff09\u306e\u5927\u304d\u3055\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001COMT\u907a\u4f1d\u5b50\u591a\u578b\u306e\u52b9\u679c\u304c\u4eba\u7a2e\uff08ethnicity\uff09\u3001\u5e74\u9f62\uff08age\uff09\u3001\u6027\u5225\uff08gender\uff09\u306a\u3069\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u5f97\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u305f\u3068\u3048\u540c\u3058\u907a\u4f1d\u5b50\u30bb\u30c3\u30c8\u3092\u6301\u3063\u3066\u3044\u305f\u3068\u3057\u3066\u3082\u3001\u305d\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\uff08gene expression\uff09\u306f\u3001\u7d4c\u9a13\u3084\u5916\u7684\u523a\u6fc0\u3001\u4ed6\u306e\u907a\u4f1d\u5b50\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u3082\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u70b9\u3082\u898b\u9003\u305b\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u81e8\u5e8a\u7684\u306a\u89b3\u70b9\u304b\u3089\u306f\u3001COMT\u306b\u95a2\u9023\u3057\u305f\u907a\u4f1d\u7684\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u306e\u7406\u89e3\u304c\u3001\u5c06\u6765\u7684\u306b\u500b\u5225\u5316\u3055\u308c\u305f\u7cbe\u795e\u533b\u7642\u306b\u8ca2\u732e\u3059\u308b\u53ef\u80fd\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u73fe\u6642\u70b9\u3067\u306f\u3001\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\uff08genotyping\uff09\u306f\u4e3b\u306b\u7814\u7a76\u306e\u67a0\u7d44\u307f\u306b\u3068\u3069\u307e\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u795e\u7d4c\u907a\u4f1d\u5b66\u3084\u7cbe\u795e\u85ac\u7406\u5b66\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u5c06\u6765\u7684\u306b\u306f\u500b\u4eba\u306e\u795e\u7d4c\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u6226\u7565\u306e\u6700\u9069\u5316\u304c\u53ef\u80fd\u3068\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3537755_s.jpg\" alt=\"\u5dee\u5225\" class=\"wp-image-12342\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3537755_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3537755_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u305d\u306e\u4e00\u65b9\u3067\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u578b\u3084\u76ae\u819a\u306e\u8272\u306a\u3069\u3092\u7406\u7531\u306b\u3001\u500b\u4eba\u304c\u504f\u898b\u3084\u5dee\u5225\u306e\u5bfe\u8c61\u3068\u306a\u3089\u306a\u3044\u3088\u3046\u5341\u5206\u306b\u6ce8\u610f\u3092\u6255\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b66\u306f\u79c1\u305f\u3061\u304c\u4e16\u754c\u3092\u3088\u308a\u6df1\u304f\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u5f37\u529b\u306a\u9053\u5177\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u79c1\u305f\u3061\u306f\u6c7a\u3057\u3066\u300c\u907a\u4f1d\u5b50\u305d\u306e\u3082\u306e\u300d\u3084\u300c\u907a\u4f1d\u5b50\u306e\u7523\u7269\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4eba\u306f\u5e38\u306b\u300c\u90e8\u5206\u306e\u7dcf\u548c\u4ee5\u4e0a\uff08more than the sum of their parts\uff09\u300d\u306e\u5b58\u5728\u3067\u3042\u308b\u3053\u3068\u3092\u5fd8\u308c\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"424\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/30299161_s.jpg\" alt=\"\u307f\u306a\u3061\u304c\u3063\u3066\u307f\u306a\u3044\u3044\" class=\"wp-image-12349\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30299161_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30299161_s-300x199.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc, \u30ab\u30c6\u30b3\u30fc\u30eb-O-\u30e1\u30c1\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u907a\u4f1d\u5b50, \u4e00\u5869\u57fa\u591a\u578b, Val158Met, \u30c9\u30fc\u30d1\u30df\u30f3, \u524d\u982d\u524d\u76ae\u8cea, \u6226\u58eb\u578b\u3068\u5fc3\u914d\u578b, \u611f\u60c5\u5236\u5fa1, \u8a18\u61b6, \u6ce8\u610f, \u8a8d\u77e5\u6a5f\u80fd, \u4e0d\u5b89, \u7d71\u5408\u5931\u8abf\u75c7, \u75db\u899a, \u907a\u4f1d\u5b50\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528, catechol-O-methyltransferase, catechol-O-methyltransferase gene, single nucleotide polymorphism, Val158Met, dopamine, prefrontal cortex, warriors and worriers, emotional regulation, memory, attention, cognitive function, anxiety, schizophrenia, pain perception, gene-environment interaction<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32029542_s.jpg\" alt=\"pochi\" class=\"wp-image-11435\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32029542_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32029542_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1017\/s1092852900014863\">Stein, D. J., Newman, T. K., Savitz, J., &amp; Ramesar, R. (2006). Warriors versus worriers: the role of COMT gene variants.\u00a0<em>CNS spectrums<\/em>,\u00a0<em>11<\/em>(10), 745\u2013748. https:\/\/doi.org\/10.1017\/s1092852900014863<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1111\/gbb.12022\">Wang, Y., Li, J., Chen, C., Chen, C., Zhu, B., Moysis, R. K., Lei, X., Li, H., Liu, Q., Xiu, D., Liu, B., Chen, W., Xue, G., &amp; Dong, Q. (2013). COMT rs4680 Met is not always the &#8216;smart allele&#8217;: Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.\u00a0<em>Genes, brain, and behavior<\/em>,\u00a0<em>12<\/em>(3), 323\u2013329. https:\/\/doi.org\/10.1111\/gbb.12022<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u4eba\u9593\u306e\u884c\u52d5\u306f\u3001\u907a\u4f1d\u7684\u7d20\u56e0\uff08genetic makeup\uff09\u3068\u795e\u7d4c\u751f\u7269\u5b66\u7684\u6a5f\u69cb\uff08neurobiological mechanisms\uff09\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u885d\u52d5\u6027\uff08impuls [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":12210,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[371,381,372,325,369,380,364,383,377,225,373,375,376,370,378,374,382,379,384,45],"class_list":["post-12189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-comt","tag-fmri","tag-val158met","tag-325","tag--o-","tag-380","tag-364","tag-383","tag-377","tag-225","tag-373","tag-375","tag-376","tag-370","tag-378","tag-374","tag-382","tag-379","tag-384","tag-genetics"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=12189"}],"version-history":[{"count":6,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12189\/revisions"}],"predecessor-version":[{"id":12356,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12189\/revisions\/12356"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/12210"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=12189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=12189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=12189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}