{"id":12357,"date":"2025-04-04T07:27:52","date_gmt":"2025-04-04T07:27:52","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=12357"},"modified":"2025-04-04T08:53:02","modified_gmt":"2025-04-04T08:53:02","slug":"osteoporosis","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/osteoporosis\/","title":{"rendered":"\u9aa8\u304c\u3082\u308d\u304f\u306a\u308b\u306e\u306f\u907a\u4f1d\u306e\u305b\u3044\uff1fLRP5\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u9aa8\u6298\u30fb\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30ea\u30b9\u30af\u306b\u95a2\u4fc2\u3057\u3066\u3044\u305f\uff01"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<p>\u9aa8\u6298\u306f\u3001\u4e3b\u306b\u9aa8\u91cf\u306e\u6e1b\u5c11\u306b\u3088\u308b\u9aa8\u306e\u5f37\u5ea6\u4f4e\u4e0b\u3092\u539f\u56e0\u3068\u3057\u3066\u767a\u751f\u3057\u3001\u4e16\u754c\u7684\u306b\u6df1\u523b\u306a\u5065\u5eb7\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u9aa8\u6298\u306f\u3001\u969c\u5bb3\u3084\u7f79\u60a3\u7387\u3001\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u306b\u52a0\u3048\u3066\u3001\u533b\u7642\u8cbb\u306e\u5897\u5927\u306b\u3082\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u75ab\u5b66\u7684\u306b\u306f\u3001\u4e16\u754c\u4eba\u53e3\u306e\u7d0420\uff05\u304c\u751f\u6daf\u306e\u3046\u3061\u306b\u5c11\u306a\u304f\u3068\u3082\u4e00\u5ea6\u306f\u9aa8\u6298\u3092\u7d4c\u9a13\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/30356949_s.jpg\" alt=\"\u3060\u308c\u306e\" class=\"wp-image-12431\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30356949_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30356949_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u9aa8\u6298\u306e\u4e3b\u306a\u539f\u56e0\u3068\u306a\u308b\u306e\u304c\u300c\u9aa8\u7c97\u3057\u3087\u3046\u75c7\uff08osteoporosis\uff09\u300d\u3067\u3059\u3002\u3053\u308c\u306f\u9aa8\u5bc6\u5ea6\uff08bone mineral density: BMD\uff09\u306e\u4f4e\u4e0b\u3068\u9aa8\u7d44\u7e54\u306e\u9032\u884c\u6027\u306e\u52a3\u5316\u3092\u7279\u5fb4\u3068\u3057\u3001\u81ea\u899a\u75c7\u72b6\u306e\u306a\u3044\u307e\u307e\u9032\u884c\u3059\u308b\u300c\u30b5\u30a4\u30ec\u30f3\u30c8\u30c7\u30a3\u30b8\u30fc\u30ba\uff08silent disease\uff09\u300d\u3068\u3055\u308c\u307e\u3059\u3002\u5168\u4e16\u754c\u30677,500\u4e07\u4eba\u4ee5\u4e0a\u304c\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306b\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u591a\u304f\u304c\u8a3a\u65ad\u3055\u308c\u306a\u3044\u307e\u307e\u904e\u3054\u3057\u3066\u304a\u308a\u3001\u9aa8\u6298\u3092\u304d\u3063\u304b\u3051\u306b\u521d\u3081\u3066\u767a\u898b\u3055\u308c\u308b\u3053\u3068\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306f\u591a\u56e0\u5b50\u7684\u75be\u60a3\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u75c7\u306b\u306f\u74b0\u5883\u56e0\u5b50\u3068\u907a\u4f1d\u7684\u7d20\u56e0\u306e\u53cc\u65b9\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u65e2\u77e5\u306e\u74b0\u5883\u56e0\u5b50\u306b\u306f\u3001\u904b\u52d5\u4e0d\u8db3\u3001\u6804\u990a\u4e0d\u826f\u3001\u55ab\u7159\u3001\u52a0\u9f62\u3001\u5438\u53ce\u4e0d\u826f\u75c7\u5019\u7fa4\u3001\u305d\u3057\u3066HIV\u611f\u67d3\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u6700\u8fd1\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u52a0\u3048\u3001\u9aa8\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u591a\u578b\uff08genetic polymorphism\uff09\u304c\u75be\u60a3\u306e\u611f\u53d7\u6027\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/30356857_s.jpg\" alt=\"\u3042\u3001\u3082\u3069\u3055\u306a\u3044\u3068\" class=\"wp-image-12424\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30356857_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30356857_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u306a\u304b\u3067\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u53d7\u5bb9\u4f53\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea5\uff08low-density lipoprotein receptor-related protein 5: LRP5\uff09\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u9aa8\u5f62\u6210\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046\u300cWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\uff08Wnt\/\u03b2-catenin signaling pathway\uff09\u300d\u306e\u5171\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u9aa8\u82bd\u7d30\u80de\uff08osteoblast\uff09\u306e\u5897\u6b96\u3068\u5206\u5316\u3092\u5236\u5fa1\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001LRP5\u306e\u6a5f\u80fd\u969c\u5bb3\u306f\u9aa8\u5f62\u6210\u306e\u4f4e\u4e0b\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u306b\u76f4\u7d50\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"687\" height=\"531\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1-2.png\" alt=\"Low-density lipoprotein receptor-related protein 5\" class=\"wp-image-12417\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1-2.png 687w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1-2-300x232.png 300w\" sizes=\"(max-width: 687px) 100vw, 687px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7279\u306b\u3001LRP5\u907a\u4f1d\u5b50\u306e18\u756a\u76ee\u306e\u30a8\u30af\u30bd\u30f3\u306b\u4f4d\u7f6e\u3059\u308b\u4e00\u5869\u57fa\u591a\u578b\uff08single nucleotide polymorphism: SNP\uff09\u3067\u3042\u308brs3736228 C&gt;T\uff08\u5225\u540d\uff1aA1330V\uff09\u306f\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u611f\u53d7\u6027\u306b\u95a2\u4e0e\u3059\u308b\u5019\u88dc\u907a\u4f1d\u5b50\u591a\u578b\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u306f\u3001\u5341\u4e8c\u6307\u8178\u306e\u30af\u30ed\u30e0\u89aa\u548c\u6027\u7d30\u80de\u306b\u304a\u3051\u308b\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u6c34\u9178\u5316\u9175\u7d201\uff08tryptophan hydroxylase 1: Tph1\uff09\u306e\u767a\u73fe\u3092\u5236\u9650\u3057\u3001\u9aa8\u5f62\u6210\u3084\u9aa8\u5bc6\u5ea6\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u3001\u3053\u308c\u307e\u3067rs3736228 C>T\u591a\u578b\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u30fb\u9aa8\u6298\u3068\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u7dcf\u5408\u7684\u306b\u8a55\u4fa1\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u3053\u306e\u30ae\u30e3\u30c3\u30d7\u3092\u57cb\u3081\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3001LRP5\u907a\u4f1d\u5b50\u591a\u578b\u3068\u9aa8\u95a2\u9023\u75be\u60a3\u3068\u306e\u95a2\u9023\u6027\u3092\u7d71\u8a08\u7684\u306b\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<p>LRP5\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u53d7\u5bb9\u4f53\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u819c\u8cab\u901a\u578b\u306e\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u9aa8\u7d44\u7e54\u3001\u4e73\u817a\u3001\u5185\u76ae\u7d30\u80de\u3001\u5e79\u7d30\u80de\u306a\u3069\u591a\u69d8\u306a\u7d44\u7e54\u3067\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f11\u756a\u67d3\u8272\u4f53\u306eq13.4\u9818\u57df\u306b\u4f4d\u7f6e\u3057\u3001\u5168\u9577\u7d04160\u30ad\u30ed\u30d9\u30fc\u30b9\uff08kb\uff09\u300123\u306e\u30a8\u30af\u30bd\u30f3\u306822\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u304b\u3089\u69cb\u6210\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"746\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo11-MfXYKRXEMYKXQCOeHMAAAeVQ.png\" alt=\"chromo11\" class=\"wp-image-12403\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo11-MfXYKRXEMYKXQCOeHMAAAeVQ.png 746w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo11-MfXYKRXEMYKXQCOeHMAAAeVQ-300x201.png 300w\" sizes=\"(max-width: 746px) 100vw, 746px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>LRP5\u306f\u3001\u30d5\u30ea\u30ba\u30eb\u30c9\u53d7\u5bb9\u4f53\uff08Frizzled receptors\uff09\u3068\u5171\u306bWnt\u30ea\u30ac\u30f3\u30c9\u3092\u8a8d\u8b58\u3059\u308b\u5171\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u9aa8\u5f62\u6210\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u9aa8\u82bd\u7d30\u80de\u306e\u5206\u5316\u3068\u9aa8\u4ee3\u8b1d\u306e\u8abf\u7bc0\u304c\u884c\u308f\u308c\u308b\u305f\u3081\u3001\u9aa8\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u5b58\u5728\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"687\" height=\"507\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1-1.png\" alt=\"Low-density lipoprotein receptor-related protein 5\" class=\"wp-image-12410\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1-1.png 687w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1-1-300x221.png 300w\" sizes=\"(max-width: 687px) 100vw, 687px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>rs3736228 C>T\u591a\u578b\u306f\u3001LRP5\u30bf\u30f3\u30d1\u30af\u8cea\u306e1330\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u304c\u30a2\u30e9\u30cb\u30f3\uff08A\uff09\u304b\u3089\u30d0\u30ea\u30f3\uff08V\uff09\u3078\u3068\u7f6e\u63db\u3055\u308c\u308b\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u3067\u3042\u308a\uff08A1330V\uff09\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6a5f\u69cb\u3092\u5f31\u4f53\u5316\u3055\u305b\u3001\u9aa8\u5bc6\u5ea6\u4f4e\u4e0b\u3084\u9aa8\u5f62\u6210\u969c\u5bb3\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u672cSNP\u306f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3084\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u304a\u3051\u308b\u6a5f\u80fd\u7684\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff08functional biomarker\uff09\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff5cDiscussion<\/h2>\n\n\n\n<p>\u672c\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u7d50\u679c\u3001LRP5 rs3736228 C>T\u591a\u578b\u304c\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u304a\u3088\u3073\u9aa8\u6298\u306e\u611f\u53d7\u6027\u4e0a\u6607\u3068\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u7279\u306b\u3001\u30a2\u30ec\u30eb\u30e2\u30c7\u30eb\u304a\u3088\u3073\u30db\u30e2\u63a5\u5408\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u8a72\u5f53\u591a\u578b\u3092\u6709\u3059\u308b\u30ad\u30e3\u30ea\u30a2\u306b\u304a\u3051\u308b\u30aa\u30c3\u30ba\u6bd4\uff08odds ratio: OR\uff09\u306f\u6709\u610f\u306b\u9ad8\u304f\u3001\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs3736228-hgtIdeo_genome_371bc_f87b10-1024x25.png\" alt=\"rs3736228\" class=\"wp-image-12396\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs3736228-hgtIdeo_genome_371bc_f87b10-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs3736228-hgtIdeo_genome_371bc_f87b10-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs3736228-hgtIdeo_genome_371bc_f87b10-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs3736228-hgtIdeo_genome_371bc_f87b10.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u591a\u578b\u306e\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001LRP5\u304cWnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u901a\u3058\u3066\u9aa8\u82bd\u7d30\u80de\u306e\u5206\u5316\u3084\u9aa8\u91cf\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u70b9\u306b\u3042\u308a\u307e\u3059\u3002rs3736228 C&gt;T\u306e\u3088\u3046\u306a\u6a5f\u80fd\u4f4e\u4e0b\u578b\u5909\u7570\u306f\u3001\u3053\u306e\u7d4c\u8def\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u59a8\u3052\u3001\u9aa8\u5f62\u6210\u3092\u6291\u5236\u3057\u3001\u9aa8\u306e\u8106\u5f31\u6027\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eba\u7a2e\u5225\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306f\u3001Caucasian\uff08\u767d\u4eba\uff09\u96c6\u56e3\u306b\u304a\u3044\u3066\u306f\u6709\u610f\u306a\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u304c\u3001Asian\uff08\u30a2\u30b8\u30a2\u4eba\uff09\u96c6\u56e3\u3067\u306f\u7d71\u8a08\u7684\u6709\u610f\u6027\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u907a\u4f1d\u5b50\u578b\u89e3\u6790\u6cd5\u306b\u304a\u3051\u308b\u9055\u3044\u3082\u7d50\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u304a\u308a\u3001TaqMan\u30a2\u30c3\u30bb\u30a4\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u6709\u610f\u306a\u95a2\u9023\u304c\u89b3\u5bdf\u3055\u308c\u305f\u4e00\u65b9\u3001\u4ed6\u306e\u624b\u6cd5\u3067\u306f\u95a2\u9023\u6027\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3458586_s.jpg\" alt=\"\u4eba\u7a2e\u6ca2\u5c71\u3042\u308a\u307e\u3059\" class=\"wp-image-12389\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3458586_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3458586_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u5236\u9650\u3082\u5b58\u5728\u3057\u307e\u3059\u3002\u307e\u305a\u3001\u89e3\u6790\u5bfe\u8c61\u306eSNP\u304crs3736228 C&gt;T\u306e\u307f\u306b\u9650\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u4ed6\u306eLRP5\u591a\u578b\u3068\u306e\u6bd4\u8f03\u3084\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u306f\u8003\u616e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u5bfe\u8c61\u96c6\u56e3\u304c\u30a2\u30b8\u30a2\u4eba\u3068\u767d\u4eba\u306b\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u3084\u30e9\u30c6\u30f3\u7cfb\u306a\u3069\u4ed6\u306e\u4eba\u7a2e\u96c6\u56e3\u306e\u30c7\u30fc\u30bf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u70b9\u3082\u4eca\u5f8c\u306e\u8ab2\u984c\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u5bb6\u65cf\u6b74\u3084\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u306e\u91cd\u75c7\u5ea6\u3001\u4f75\u5b58\u75be\u60a3\u3068\u3044\u3063\u305f\u81e8\u5e8a\u7684\u80cc\u666f\u60c5\u5831\u304c\u89e3\u6790\u306b\u542b\u307e\u308c\u3066\u3044\u306a\u3044\u70b9\u3001\u6bcd\u96c6\u56e3\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306e\u9650\u754c\u3082\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u3067\u3082\u3001\u672c\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001van Meurs\u3089\u3084Ferrari\u3089\u306e\u5148\u884c\u7814\u7a76\u3068\u3082\u6574\u5408\u7684\u3067\u3042\u308a\u3001LRP5\u591a\u578b\u304c\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u304a\u3088\u3073\u9aa8\u6298\u306e\u907a\u4f1d\u7684\u6c7a\u5b9a\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"687\" height=\"511\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1.png\" alt=\"Low-density lipoprotein receptor-related protein 5\" class=\"wp-image-12382\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1.png 687w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-O75197-F1-300x223.png 300w\" sizes=\"(max-width: 687px) 100vw, 687px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<p>\u6587\u732e\u691c\u7d22\u306f\u30012014\u5e744\u670830\u65e5\u307e\u3067\u306b\u767a\u8868\u3055\u308c\u305f\u82f1\u8a9e\u304a\u3088\u3073\u4e2d\u56fd\u8a9e\u6587\u732e\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001PubMed\u3001MEDLINE\u3001Embase\u3001Cochrane Library\u306a\u3069\u306e\u96fb\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304a\u3088\u3073\u4e2d\u56fd\u306e\u6587\u732e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u6a2a\u65ad\u7684\u306b\u691c\u7d22\u3057\u307e\u3057\u305f\u3002\u691c\u7d22\u8a9e\u306b\u306f\u300c\u9aa8\u6298\uff08fracture\uff09\u300d\u300c\u9aa8\u7c97\u3057\u3087\u3046\u75c7\uff08osteoporosis\uff09\u300d\u300cLRP5\u300d\u306a\u3069\u306e\u533b\u5b66\u4e3b\u984c\u8a9e\uff08MeSH\uff09\u304a\u3088\u3073\u81ea\u7531\u8a9e\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002\u52a0\u3048\u3066\u3001\u53c2\u8003\u6587\u732e\u306e\u624b\u52d5\u691c\u7d22\u3082\u5b9f\u65bd\u3057\u3001\u7db2\u7f85\u7684\u306a\u53ce\u96c6\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23844389_s.jpg\" alt=\"\u672c\" class=\"wp-image-12293\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23844389_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23844389_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7d44\u307f\u5165\u308c\u57fa\u6e96\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a(1) \u30b1\u30fc\u30b9\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7814\u7a76\u3067\u3042\u308b\u3053\u3068\u3001(2) LRP5 rs3736228 C&gt;T\u591a\u578b\u3068\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u307e\u305f\u306f\u9aa8\u6298\u3068\u306e\u95a2\u9023\u6027\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u3053\u3068\u3001(3) \u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u306e\u8a3a\u65ad\u57fa\u6e96\u3092\u6e80\u305f\u3057\u305f\u75c7\u4f8b\u3067\u3042\u308b\u3053\u3068\u3001(4) \u30b8\u30a7\u30ce\u30bf\u30a4\u30d7\u983b\u5ea6\u306b\u95a2\u3059\u308b\u539f\u30c7\u30fc\u30bf\u304c\u660e\u793a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3001(5) \u5bfe\u7167\u7fa4\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u983b\u5ea6\u304c\u30cf\u30fc\u30c7\u30a3\u30fb\u30ef\u30a4\u30f3\u30d9\u30eb\u30b0\u5e73\u8861\uff08Hardy-Weinberg equilibrium: HWE\uff09\u306b\u5f93\u3063\u3066\u3044\u308b\u3053\u3068\u3001\u306a\u3069\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u306e\u54c1\u8cea\u8a55\u4fa1\u306b\u306fNewcastle-Ottawa Scale\uff08NOS\uff09\u3092\u7528\u3044\u3001\u30b9\u30b3\u30a2\u304c7\u70b9\u4ee5\u4e0a\u306e\u7814\u7a76\u3092\u300c\u9ad8\u54c1\u8cea\u300d\u3068\u3057\u3066\u63a1\u7528\u3057\u307e\u3057\u305f\u30022\u540d\u306e\u72ec\u7acb\u3057\u305f\u67fb\u8aad\u8005\u304c\u30c7\u30fc\u30bf\u62bd\u51fa\u3068\u8a55\u4fa1\u3092\u884c\u3044\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u7b2c\u4e09\u8005\u304c\u4ecb\u5165\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg\" alt=\"\" class=\"wp-image-11365\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7d71\u8a08\u89e3\u6790\u306b\u306fSTATA\uff08Version 12.0\uff09\u3092\u4f7f\u7528\u3057\u30015\u3064\u306e\u907a\u4f1d\u30e2\u30c7\u30eb\uff08\u30a2\u30ec\u30eb\u3001\u512a\u6027\u3001\u52a3\u6027\u3001\u30db\u30e2\u63a5\u5408\u3001\u30d8\u30c6\u30ed\u63a5\u5408\uff09\u306b\u304a\u3044\u3066\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09\u306895\uff05\u4fe1\u983c\u533a\u9593\uff0895% CI\uff09\u3092\u7b97\u51fa\u3057\u307e\u3057\u305f\u3002\u7570\u8cea\u6027\uff08heterogeneity\uff09\u306fCochran\u306eQ\u691c\u5b9a\u304a\u3088\u3073I\u00b2\u7d71\u8a08\u91cf\u306b\u3088\u308a\u8a55\u4fa1\u3057\u3001P\u5024\uff1c0.05\u307e\u305f\u306fI\u00b2\uff1e50\uff05\u3067\u3042\u308c\u3070\u30e9\u30f3\u30c0\u30e0\u52b9\u679c\u30e2\u30c7\u30eb\u3092\u9069\u7528\u3057\u307e\u3057\u305f\u3002\u611f\u5ea6\u5206\u6790\u304a\u3088\u3073\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306e\u8a55\u4fa1\u306b\u306fEgger\u56de\u5e30\u691c\u5b9a\u3068\u30d5\u30a1\u30f3\u30cd\u30eb\u30d7\u30ed\u30c3\u30c8\u3092\u7528\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<p>\u6700\u521d\u306b278\u4ef6\u306e\u6587\u732e\u304c\u62bd\u51fa\u3055\u308c\u3001\u305d\u306e\u3046\u3061\u6700\u7d42\u7684\u306b7\u4ef6\u306e\u30b1\u30fc\u30b9\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7814\u7a76\uff08\u75c7\u4f8b\u6570\uff1a907\u540d\u3001\u5bfe\u7167\u6570\uff1a1,865\u540d\uff09\u304c\u89e3\u6790\u5bfe\u8c61\u3068\u3057\u3066\u9078\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u306e\u3046\u3061\u30012\u4ef6\u306f\u9aa8\u6298\u30015\u4ef6\u306f\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3092\u5bfe\u8c61\u3068\u3057\u3066\u304a\u308a\u30013\u4ef6\u306f\u767d\u4eba\u30014\u4ef6\u306f\u30a2\u30b8\u30a2\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3082\u306e\u3067\u3057\u305f\u3002\u907a\u4f1d\u5b50\u578b\u89e3\u6790\u306b\u306f\u30015\u4ef6\u304cTaqMan\u30a2\u30c3\u30bb\u30a4\u3092\u7528\u3044\u30012\u4ef6\u306f\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u307e\u305f\u306f\u30d4\u30ed\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3092\u7528\u3044\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31952038_s-1.jpg\" alt=\"\u304a\u8aad\u307f\u3057\u307e\u3059\" class=\"wp-image-11618\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31952038_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31952038_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5168\u4f53\u306e\u89e3\u6790\u3067\u306f\u3001rs3736228 C&gt;T\u591a\u578b\u30ad\u30e3\u30ea\u30a2\u306b\u304a\u3051\u308b\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u304a\u3088\u3073\u9aa8\u6298\u30ea\u30b9\u30af\u304c\u30a2\u30ec\u30eb\u30e2\u30c7\u30eb\u3067\u6709\u610f\u306b\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u512a\u6027\u30e2\u30c7\u30eb\u3067\u306f\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08OR = 1.19, 95% CI = 0.97\u20131.46, P = 0.103\uff09\u3002<\/p>\n\n\n\n<p>\u4eba\u7a2e\u5225\u89e3\u6790\u3067\u306f\u3001\u767d\u4eba\u96c6\u56e3\u306b\u304a\u3044\u3066T\u30a2\u30ec\u30eb\u30ad\u30e3\u30ea\u30a2\u306f\u6709\u610f\u306b\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3057\u3066\u304a\u308a\uff08T vs. C: OR = 1.42, P = 0.027; CT + TT vs. CC: OR = 1.56, P = 0.018\uff09\u3001\u30a2\u30b8\u30a2\u4eba\u3067\u306f\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u5bfe\u7167\u7fa4\u306e\u51fa\u5178\u5225\u306b\u307f\u308b\u3068\u3001\u6bcd\u96c6\u56e3\u30d9\u30fc\u30b9\u3067\u306f\u30a2\u30ec\u30eb\u3001\u512a\u6027\u3001\u30db\u30e2\u63a5\u5408\u30e2\u30c7\u30eb\u3067\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u793a\u3055\u308c\u3001\u75c5\u9662\u30d9\u30fc\u30b9\u3067\u306f\u52a3\u6027\u3001\u30db\u30e2\u63a5\u5408\u3001\u30d8\u30c6\u30ed\u63a5\u5408\u30e2\u30c7\u30eb\u3067\u540c\u69d8\u306e\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31406281_s-1.jpg\" alt=\"\u8db3\u305f\u306f\u30ad\u30c3\u30c8\u5927\u4e08\u592b\" class=\"wp-image-12375\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31406281_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31406281_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u75be\u60a3\u306e\u7a2e\u985e\u5225\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306f\u3001\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u3067\u306f\u30a2\u30ec\u30eb\u30e2\u30c7\u30eb\u3067\u3001\u9aa8\u6298\u3067\u306f\u52a3\u6027\u30fb\u30db\u30e2\u30fb\u30d8\u30c6\u30ed\u63a5\u5408\u30e2\u30c7\u30eb\u3067\u6709\u610f\u306a\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002TaqMan\u6cd5\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u306f\u3001\u591a\u304f\u306e\u907a\u4f1d\u30e2\u30c7\u30eb\u3067\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u793a\u3055\u308c\u305f\u4e00\u65b9\u3001\u975eTaqMan\u6cd5\u3067\u306f\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u611f\u5ea6\u5206\u6790\u3067\u306f\u3001\u3044\u305a\u308c\u306e\u5358\u4e00\u7814\u7a76\u3082\u5168\u4f53\u306e\u7d50\u8ad6\u306b\u6c7a\u5b9a\u7684\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306b\u95a2\u3059\u308bEgger\u691c\u5b9a\u3067\u306f\u6709\u610f\u306a\u30d0\u30a4\u30a2\u30b9\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u30a2\u30ec\u30eb\u30e2\u30c7\u30eb: P = 0.908\u3001\u512a\u6027\u30e2\u30c7\u30eb: P = 0.847\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3088\u308a\u3001LRP5\u907a\u4f1d\u5b50\u306ers3736228 C>T\u591a\u578b\u306f\u3001\u7279\u306b\u767d\u4eba\u96c6\u56e3\u306b\u304a\u3044\u3066\u9aa8\u7c97\u3057\u3087\u3046\u75c7\u304a\u3088\u3073\u9aa8\u6298\u306e\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u591a\u578b\u306f\u3001\u9aa8\u95a2\u9023\u75be\u60a3\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3084\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u304a\u3051\u308b\u4e88\u6e2c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u81e8\u5e8a\u7684\u4fa1\u5024\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u4eca\u5f8c\u306f\u4ed6\u306eSNP\u3084\u74b0\u5883\u56e0\u5b50\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3001\u3088\u308a\u591a\u69d8\u306a\u4eba\u7a2e\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3001\u81e8\u5e8a\u80cc\u666f\u56e0\u5b50\u3092\u542b\u3081\u305f\u5927\u898f\u6a21\u7814\u7a76\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u7279\u306b\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u3084\u30e9\u30c6\u30f3\u7cfb\u306a\u3069\u4ed6\u306e\u6c11\u65cf\u30b0\u30eb\u30fc\u30d7\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3084\u3001\u8907\u6570\u306eSNP\u3092\u540c\u6642\u306b\u8a55\u4fa1\u3059\u308b\u89e3\u6790\u306b\u3088\u308a\u3001\u672c\u7d50\u679c\u306e\u4e00\u822c\u5316\u53ef\u80fd\u6027\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u4eca\u5f8c\u306e\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4552654_s.jpg\" alt=\"\u3060\u3044\u3058\u3087\u3046\u3070\u306a\u3044\u3051\u3069\u5927\u4e08\u592b\" class=\"wp-image-12368\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4552654_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4552654_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u9aa8\u6298, \u9aa8\u7c97\u3057\u3087\u3046\u75c7, \u4e00\u5869\u57fa\u591a\u578b, LRP5\u907a\u4f1d\u5b50, rs3736228, \u30a2\u30ec\u30eb\u983b\u5ea6, Wnt\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def, \u9aa8\u5bc6\u5ea6, \u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9, fracture, osteoporosis, single nucleotide polymorphism, LRP5 gene, rs3736228, allele frequency, Wnt signaling pathway, bone mineral density, meta-analysis<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32049763_s.jpg\" alt=\"\u767d\u8863\u5973\u6027\" class=\"wp-image-12152\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32049763_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32049763_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1155\/2014\/290531\">Xu, G. Y., Qiu, Y., &amp; Mao, H. J. (2014). Common polymorphism in the LRP5 gene may increase the risk of bone fracture and osteoporosis.\u00a0<em>BioMed research international<\/em>,\u00a0<em>2014<\/em>, 290531. https:\/\/doi.org\/10.1155\/2014\/290531<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). 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G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u9aa8\u6298\u306f\u3001\u4e3b\u306b\u9aa8\u91cf\u306e\u6e1b\u5c11\u306b\u3088\u308b\u9aa8\u306e\u5f37\u5ea6\u4f4e\u4e0b\u3092\u539f\u56e0\u3068\u3057\u3066\u767a\u751f\u3057\u3001\u4e16\u754c\u7684\u306b\u6df1\u523b\u306a\u5065\u5eb7\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u9aa8\u6298\u306f\u3001\u969c\u5bb3\u3084\u7f79\u60a3\u7387\u3001\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u306b\u52a0\u3048\u3066\u3001\u533b\u7642\u8cbb\u306e\u5897\u5927\u306b\u3082\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u75ab\u5b66\u7684\u306b\u306f\u3001\u4e16\u754c [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":12361,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[387,388,394,331,225,59,337,222,395,391,390,392,393,386,396,399,385,398,389,397],"class_list":["post-12357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-lrp5","tag-rs3736228","tag-wnt","tag-331","tag-225","tag-59","tag-337","tag-222","tag-395","tag-391","tag-390","tag-392","tag-393","tag-386","tag-396","tag-399","tag-385","tag-398","tag-389","tag-397"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=12357"}],"version-history":[{"count":4,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12357\/revisions"}],"predecessor-version":[{"id":12438,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12357\/revisions\/12438"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/12361"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=12357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=12357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=12357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}