{"id":12439,"date":"2025-04-04T07:55:56","date_gmt":"2025-04-04T07:55:56","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=12439"},"modified":"2025-04-04T08:53:02","modified_gmt":"2025-04-04T08:53:02","slug":"arrowtotheknee","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/arrowtotheknee\/","title":{"rendered":"\u3072\u3056\u306e\u75db\u307f\u3001\u907a\u4f1d\u5b50\u306e\u305b\u3044\u304b\u3082\uff1f\u819d\u95a2\u7bc0\u75c7\u3068GDF5\u907a\u4f1d\u5b50\u306e\u610f\u5916\u306a\u95a2\u4fc2"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u80cc\u666f\uff5cBackground<\/strong><\/h2>\n\n\n\n<p>\u819d\u95a2\u7bc0\u75c7\uff08knee osteoarthritis\uff09\u306f\u3001\u4e16\u754c\u4e2d\u306e\u4e2d\u9ad8\u5e74\u5c64\u306b\u591a\u304f\u307f\u3089\u308c\u308b\u6700\u3082\u4e00\u822c\u7684\u306a\u7b4b\u9aa8\u683c\u7cfb\u75be\u60a3\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u95a2\u7bc0\u8edf\u9aa8\u306e\u9032\u884c\u6027\u306e\u5909\u6027\u3001\u9aa8\u306e\u518d\u69cb\u7bc9\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u7279\u5fb4\u3068\u3057\u3001\u6162\u6027\u7684\u306a\u75bc\u75db\u3084\u3053\u308f\u3070\u308a\u3001\u53ef\u52d5\u57df\u306e\u5236\u9650\u3001\u6700\u7d42\u7684\u306b\u306f\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3053\u306e\u75be\u60a3\u306f\u3001\u533b\u7642\u6a5f\u95a2\u306e\u53d7\u8a3a\u4ef6\u6570\u3001\u4eba\u5de5\u95a2\u7bc0\u7f6e\u63db\u8853\u306e\u65bd\u884c\u4ef6\u6570\u3001\u9577\u671f\u30b1\u30a2\u306e\u9700\u8981\u306a\u3069\u3092\u901a\u3058\u3066\u3001\u4fdd\u5065\u533b\u7642\u8cc7\u6e90\u306b\u5927\u304d\u306a\u8ca0\u62c5\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23521036_s.jpg\" alt=\"hiza\" class=\"wp-image-12469\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23521036_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23521036_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u819d\u95a2\u7bc0\u75c7\u306e\u767a\u75c7\u306b\u306f\u3001\u52a0\u9f62\u5909\u5316\u3001\u6a5f\u68b0\u7684\u8ca0\u8377\u3001\u708e\u75c7\u3001\u4ee3\u8b1d\u7570\u5e38\uff08\u4f8b\uff1a\u80a5\u6e80\uff09\u306a\u3069\u306e\u8907\u6570\u306e\u56e0\u5b50\u304c\u95a2\u4e0e\u3057\u307e\u3059\u304c\u3001\u8fd1\u5e74\u3067\u306f\u907a\u4f1d\u7684\u7d20\u56e0\u306e\u91cd\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u53cc\u5b50\u7814\u7a76\u3084\u5bb6\u65cf\u96c6\u7a4d\u6027\u306e\u7814\u7a76\u304b\u3089\u306f\u3001\u819d\u95a2\u7bc0\u75c7\u306e\u611f\u53d7\u6027\u306e40\u301c65\uff05\u304c\u907a\u4f1d\u7684\u8981\u56e0\u306b\u8d77\u56e0\u3059\u308b\u3068\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u6570\u591a\u304f\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS: genome-wide association study\uff09\u304c\u884c\u308f\u308c\u3001\u75be\u60a3\u611f\u53d7\u6027\u306b\u95a2\u4e0e\u3059\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3084\u907a\u4f1d\u5b50\u591a\u578b\u306e\u540c\u5b9a\u304c\u9032\u3081\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"601\" height=\"670\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P43026-F1.png\" alt=\"Growth\/differentiation factor 5\" class=\"wp-image-12476\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P43026-F1.png 601w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P43026-F1-269x300.png 269w\" sizes=\"(max-width: 601px) 100vw, 601px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u305d\u306e\u4e2d\u3067\u3082\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001GDF5\uff08Growth Differentiation Factor 5\uff09\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306f\u95a2\u7bc0\u3084\u9aa8\u683c\u7cfb\u306e\u767a\u751f\u30fb\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u306f\u3001GDF5\u907a\u4f1d\u5b50\u5185\u306e\u7279\u5b9a\u306e\u4e00\u5869\u57fa\u591a\u578b\uff08SNP: single nucleotide polymorphism\uff09\u3067\u3042\u308brs143383\u304c\u3001\u819d\u95a2\u7bc0\u75c7\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u95a2\u9023\u304c\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u6709\u610f\u6c34\u6e96\uff08p &lt; 5\u00d710\u207b\u2078\uff09\u3092\u8d85\u3048\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08\u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/strong><\/h2>\n\n\n\n<p>GDF5\uff08\u6210\u9577\u5206\u5316\u56e0\u5b505\uff09\u907a\u4f1d\u5b50\u306f\u3001TGF-\u03b2\uff08Transforming Growth Factor-beta\uff09\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5206\u5b50\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u7d30\u80de\u306e\u5897\u6b96\u30fb\u5206\u5316\u30fb\u7d44\u7e54\u5f62\u6210\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002GDF5\u306f\u7279\u306b\u9aa8\u7aef\u6210\u9577\u677f\u3001\u95a2\u7bc0\u8edf\u9aa8\u3001\u6ed1\u819c\u69cb\u9020\u306a\u3069\u3001\u9aa8\u3084\u95a2\u7bc0\u306e\u767a\u751f\u30fb\u7dad\u6301\u306b\u91cd\u8981\u306a\u90e8\u4f4d\u3067\u9ad8\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u306f\u3001GDF5\u304c\u9771\u5e2f\u3001\u8171\u3001\u9aa8\u306e\u640d\u50b7\u6cbb\u7652\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs143383-hgtIdeo_genome_1fc398_f8e480-1024x25.png\" alt=\"rs143383\" class=\"wp-image-12455\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs143383-hgtIdeo_genome_1fc398_f8e480-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs143383-hgtIdeo_genome_1fc398_f8e480-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs143383-hgtIdeo_genome_1fc398_f8e480-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs143383-hgtIdeo_genome_1fc398_f8e480.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>rs143383\u306f\u3001GDF5\u907a\u4f1d\u5b50\u306e5&#8217;\u975e\u7ffb\u8a33\u9818\u57df\uff085\u2032 UTR\uff09\u306b\u4f4d\u7f6e\u3059\u308b\u6a5f\u80fd\u7684SNP\u3067\u3059\u30025\u2032 UTR\u306f\u7ffb\u8a33\u3092\u958b\u59cb\u3059\u308b\u524d\u306e\u907a\u4f1d\u5b50\u914d\u5217\u3067\u3042\u308a\u3001mRNA\u306e\u5b89\u5b9a\u6027\u3084\u7ffb\u8a33\u52b9\u7387\u3092\u8abf\u7bc0\u3059\u308b\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u591a\u578b\u306fT\uff08\u30c1\u30df\u30f3\uff09\u3068C\uff08\u30b7\u30c8\u30b7\u30f3\uff09\u306e\u7f6e\u63db\u306b\u3088\u3063\u3066\u69cb\u6210\u3055\u308c\u3001T\u30a2\u30ec\u30eb\u3092\u6301\u3064\u500b\u4f53\u3067\u306fGDF5\u306e\u767a\u73fe\u91cf\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u95a2\u7bc0\u69cb\u9020\u306e\u7dad\u6301\u306b\u5fc5\u8981\u306aGDF5\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cf\u304c\u6e1b\u5c11\u3057\u3001\u95a2\u7bc0\u75c7\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"737\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo20-MfXYXZHdJJZZYCKNDQAAABaX.png\" alt=\"chromo20\" class=\"wp-image-12462\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo20-MfXYXZHdJJZZYCKNDQAAABaX.png 737w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo20-MfXYXZHdJJZZYCKNDQAAABaX-300x204.png 300w\" sizes=\"(max-width: 737px) 100vw, 737px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306ers143383 T\u30a2\u30ec\u30eb\u306f\u3001\u3053\u308c\u307e\u3067\u30a2\u30b8\u30a2\u4eba\u96c6\u56e3\u3067\u306e\u819d\u95a2\u7bc0\u75c7\u3068\u306e\u95a2\u9023\u304c\u8907\u6570\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u518d\u73fe\u6027\u306e\u9ad8\u3044\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u6b27\u5dde\u7cfb\u96c6\u56e3\u3067\u306f\u305d\u306e\u52b9\u679c\u304c\u6bd4\u8f03\u7684\u5c0f\u3055\u3044\u50be\u5411\u306b\u3042\u308b\u305f\u3081\u3001\u591a\u6c11\u65cf\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5927\u898f\u6a21\u30e1\u30bf\u89e3\u6790\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001GDF5\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u5b58\u5728\u3059\u308brs143383\u591a\u578b\u304c\u3001\u819d\u95a2\u7bc0\u75c7\u306e\u30ea\u30b9\u30af\u3068\u6709\u610f\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u3001T\u30a2\u30ec\u30eb\u3092\u6301\u3064\u500b\u4f53\u3067\u306f\u819d\u95a2\u7bc0\u75c7\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c17\uff05\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\uff08\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff091.17\u300195\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff091.12\u301c1.23\uff09\u3001\u3053\u306e\u95a2\u9023\u306f\u7d71\u8a08\u5b66\u7684\u306b\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u6709\u610f\u6c34\u6e96\uff08p = 6.2\u00d710\u207b\u00b9\u00b9\uff09\u3092\u6e80\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u89e3\u6790\u5bfe\u8c61\u3092\u6b27\u5dde\u7cfb\u96c6\u56e3\u306b\u9650\u5b9a\u3057\u3066\u3082\u540c\u69d8\u306e\u95a2\u9023\u304c\u78ba\u8a8d\u3055\u308c\uff08p = 8.3\u00d710\u207b\u2079\uff09\u3001\u4eba\u7a2e\u306b\u4f9d\u5b58\u3057\u306a\u3044\u666e\u904d\u7684\u306a\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1230231_s.jpg\" alt=\"\u3072\u3056\" class=\"wp-image-12448\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1230231_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1230231_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u611f\u5ea6\u5206\u6790\u3068\u3057\u3066\u3001\u30cf\u30fc\u30c7\u30a3\u30fb\u30ef\u30a4\u30f3\u30d9\u30eb\u30b0\u5e73\u8861\uff08Hardy\u2013Weinberg equilibrium\uff09\u306b\u9055\u53cd\u3057\u3066\u3044\u305f1\u7814\u7a76\u3092\u9664\u5916\u3057\u305f\u5834\u5408\u3001\u95a2\u9023\u6027\u306f\u3055\u3089\u306b\u5f37\u307e\u308a\uff08OR 1.18\u3001p = 4.1\u00d710\u207b\u00b9\u00b9\uff09\u3001\u672c\u7d50\u679c\u306e\u9811\u5065\u6027\u304c\u88cf\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u6027\u5225\u306b\u3088\u308b\u5c64\u5225\u89e3\u6790\u3067\u306f\u3001\u5973\u6027\u306b\u304a\u3051\u308b\u52b9\u679c\u91cf\uff08OR 1.19\uff09\u304c\u7537\u6027\uff08OR 1.14\uff09\u3088\u308a\u3084\u3084\u5927\u304d\u3044\u50be\u5411\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u304c\u3001\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u6027\u5dee\u3092\u554f\u308f\u305a\u5b89\u5b9a\u3057\u305f\u95a2\u9023\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7814\u7a76\u9593\u306e\u7570\u8cea\u6027\uff08heterogeneity\uff09\u306f\u691c\u51fa\u3055\u308c\u305a\u3001\u7d50\u679c\u306e\u4e00\u8cab\u6027\u3068\u4fe1\u983c\u6027\u304c\u5f37\u8abf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"572\" height=\"637\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P43026-F1-1.png\" alt=\"Growth\/differentiation factor 5\" class=\"wp-image-12483\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P43026-F1-1.png 572w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P43026-F1-1-269x300.png 269w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4ee5\u4e0a\u304b\u3089\u3001GDF5 rs143383\u306f\u6a5f\u80fd\u7684\u306a\u907a\u4f1d\u7684\u591a\u578b\u3067\u3042\u308a\u3001\u819d\u95a2\u7bc0\u75c7\u306e\u907a\u4f1d\u7684\u7d20\u56e0\u3068\u3057\u3066\u5f37\u529b\u304b\u3064\u518d\u73fe\u6027\u306e\u9ad8\u3044\u8a3c\u62e0\u3092\u6301\u3064\u3053\u3068\u304c\u660e\u78ba\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306e\u30ea\u30b9\u30af\u4e88\u6e2c\u3084\u6cbb\u7642\u6a19\u7684\u306e\u691c\u8a0e\u306b\u304a\u3044\u3066\u3001GDF5\u306e\u5f79\u5272\u306f\u91cd\u8981\u306a\u3082\u306e\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u82f1\u56fd\u3001\u30a8\u30b9\u30c8\u30cb\u30a2\u3001\u30aa\u30e9\u30f3\u30c0\u306e3\u304b\u56fd\u304b\u3089\u5f97\u3089\u308c\u305f\u8907\u6570\u306e\u72ec\u7acb\u30b3\u30db\u30fc\u30c8\u3092\u7d71\u5408\u3057\u3001\u819d\u95a2\u7bc0\u75c7\u3068rs143383\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u65b0\u305f\u306b\u53ce\u96c6\u3055\u308c\u305f\u819d\u95a2\u7bc0\u75c7\u60a3\u80052,235\u4f8b\u304a\u3088\u3073\u5bfe\u7167\u7fa43,303\u4f8b\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3001\u3055\u3089\u306bChingford Study\uff08259\u4f8b\u306e\u60a3\u8005\u3001509\u4f8b\u306e\u5bfe\u7167\uff09\u304a\u3088\u3073\u904e\u53bb\u306b\u767a\u8868\u3055\u308c\u305f\u5927\u898f\u6a21\u30e1\u30bf\u89e3\u6790\u306e\u7d50\u679c\u3092\u52a0\u3048\u3001\u5168\u4f53\u306e\u89e3\u6790\u5bfe\u8c61\u3092\u62e1\u5927\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/2307286_s.jpg\" alt=\"\u30ef\u30b7\u306b\u819d\u3092\u4efb\u305b\u306a\" class=\"wp-image-12490\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2307286_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2307286_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u82f1\u56fd\u304a\u3088\u3073\u30a8\u30b9\u30c8\u30cb\u30a2\u306e\u30b5\u30f3\u30d7\u30eb\u306f\u3001Kbioscience\u793e\uff08\u82f1\u56fd\u30d8\u30ea\u30d5\u30a9\u30fc\u30c9\u30b7\u30e3\u30fc\uff09\u306b\u3088\u308a\u65e2\u5b58\u306e\u624b\u6cd5\u3067\u907a\u4f1d\u5b50\u578b\u89e3\u6790\u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u30ed\u30c3\u30c6\u30eb\u30c0\u30e0\u7814\u7a76\uff08Rotterdam Study III\uff09\u3067\u306f\u3001\u3059\u3067\u306b\u69cb\u7bc9\u3055\u308c\u305f\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304b\u3089\u8a72\u5f53\u30c7\u30fc\u30bf\u304c\u62bd\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u653e\u5c04\u7dda\u8a3a\u65ad\u3084\u81e8\u5e8a\u8a55\u4fa1\u306e\u624b\u6cd5\u306b\u3064\u3044\u3066\u306f\u3001\u5148\u884c\u6587\u732e\u3067\u8a73\u7d30\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6700\u7d42\u7684\u306b\u3001\u6b27\u5dde\u7cfb\u88ab\u9a13\u8005\u304b\u3089\u306f10,103\u540d\u306e\u5bfe\u7167\u30686,861\u540d\u306e\u819d\u95a2\u7bc0\u75c7\u60a3\u8005\u3001\u30a2\u30b8\u30a2\u7cfb\u88ab\u9a13\u8005\u304b\u3089\u306f1,844\u540d\u306e\u5bfe\u7167\u3068718\u540d\u306e\u60a3\u8005\u3092\u542b\u3080\u3001\u5341\u5206\u306a\u7d71\u8a08\u5b66\u7684\u691c\u51fa\u529b\uff0886\uff05\uff09\u3092\u5099\u3048\u305f\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u304c\u69cb\u7bc9\u3055\u308c\u307e\u3057\u305f\uff08\u52b9\u679c\u91cfOR 1.15\u4ee5\u4e0a\u3092\u691c\u51fa\u53ef\u80fd\uff09\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31944675_s.jpg\" alt=\"\u7768\u3093\u3067\u308b\u5973\u6027\" class=\"wp-image-11499\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31944675_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31944675_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3059\u3079\u3066\u306e\u7814\u7a76\u3067\u306f\u3001\u502b\u7406\u5be9\u67fb\u59d4\u54e1\u4f1a\u306b\u3088\u308b\u627f\u8a8d\u304c\u53d6\u5f97\u3055\u308c\u3001\u53c2\u52a0\u8005\u304b\u3089\u306e\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30fb\u30b3\u30f3\u30bb\u30f3\u30c8\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u7d50\u679c\uff5cResults<\/strong><\/h2>\n\n\n\n<p>\u30e1\u30bf\u89e3\u6790\u306e\u7d50\u679c\u3001rs143383 T\u30a2\u30ec\u30eb\u304c\u819d\u95a2\u7bc0\u75c7\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u6709\u610f\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u5168\u30b5\u30f3\u30d7\u30eb\u3067\u306e\u30aa\u30c3\u30ba\u6bd4\u306f1.17\uff0895\uff05CI 1.12\u301c1.23\uff09\u3001p\u5024\u306f6.2\u00d710\u207b\u00b9\u00b9\u306b\u9054\u3057\u307e\u3057\u305f\u3002\u6b27\u5dde\u7cfb\u88ab\u9a13\u8005\u306e\u307f\u3067\u306e\u89e3\u6790\u306b\u304a\u3044\u3066\u3082p = 8.3\u00d710\u207b\u2079\u3068\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u6709\u610f\u6c34\u6e96\uff08p &lt; 5\u00d710\u207b\u2078\uff09\u3092\u5927\u304d\u304f\u4e0b\u56de\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg\" alt=\"\" class=\"wp-image-11365\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Hardy\u2013Weinberg\u5e73\u8861\u306b\u9055\u53cd\u3057\u3066\u3044\u305f1\u7814\u7a76\u3092\u9664\u5916\u3057\u305f\u5834\u5408\u3001\u95a2\u9023\u6027\u306f\u3055\u3089\u306b\u5f37\u307e\u308a\uff08OR 1.18\u3001p = 4.1\u00d710\u207b\u00b9\u00b9\uff09\u3001\u95a2\u9023\u306e\u78ba\u5b9f\u6027\u304c\u5897\u3057\u307e\u3057\u305f\u3002\u6027\u5225\u3054\u3068\u306e\u5206\u6790\u3067\u306f\u3001\u7537\u6027\u3067\u306eOR\u304c1.14\uff08p = 1.6\u00d710\u207b\u00b3\uff09\u3001\u5973\u6027\u3067\u306eOR\u304c1.19\uff08p = 3.7\u00d710\u207b\u2076\uff09\u3068\u3001\u4e21\u7fa4\u306b\u304a\u3044\u3066\u6709\u610f\u306a\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1265778_s.jpg\" alt=\"\u3072\u3056\" class=\"wp-image-12498\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1265778_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1265778_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5404\u7814\u7a76\u306b\u304a\u3051\u308b\u30a2\u30ec\u30eb\u983b\u5ea6\u3084OR\u3082\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u4f8b\u3048\u3070Chingford Study\u3067\u306f\u3001T\u30a2\u30ec\u30eb\u983b\u5ea6\u304c\u60a3\u8005\u7fa4\u306767.6%\u3001\u5bfe\u7167\u7fa4\u306759.5%\u3001\u30aa\u30c3\u30ba\u6bd4\u306f1.42\uff0895% CI 1.13\u301c1.77\uff09\u3068\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u7814\u7a76\u9593\u3067\u306e\u52b9\u679c\u65b9\u5411\u304c\u4e00\u8cab\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u652f\u6301\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7d50\u8ad6\uff5cConclusion<\/strong><\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001GDF5\u907a\u4f1d\u5b50\u306ers143383\u591a\u578b\u304c\u819d\u95a2\u7bc0\u75c7\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u95a2\u9023\u3092\u6301\u3064\u3053\u3068\u304c\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u6709\u610f\u6c34\u6e96\u3092\u6e80\u305f\u3059\u5f62\u3067\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u95a2\u9023\u306f\u8907\u6570\u306e\u72ec\u7acb\u3057\u305f\u30b3\u30db\u30fc\u30c8\u3067\u518d\u73fe\u3055\u308c\u3001\u6027\u5225\u3084\u4eba\u7a2e\u306b\u95a2\u308f\u3089\u305a\u4e00\u8cab\u3057\u3066\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8a55\u4fa1\u3001\u500b\u5225\u5316\u533b\u7642\u3001\u306a\u3089\u3073\u306bGDF5\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6226\u7565\u306e\u958b\u767a\u306b\u304a\u3044\u3066\u3001\u672c\u591a\u578b\u306f\u91cd\u8981\u306a\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/5006293_s.jpg\" alt=\"\u3072\u3056\u3041\" class=\"wp-image-12505\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/5006293_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/5006293_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/strong><\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>GDF5, rs143383, \u819d\u95a2\u7bc0\u75c7, \u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790, \u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50, \u4e00\u5869\u57fa\u591a\u578b<br>GDF5, rs143383, knee osteoarthritis, genome-wide association study, genetic risk factor, single nucleotide polymorphism (SNP)<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31753901_s.jpg\" alt=\"\u30d2\u30b6\" class=\"wp-image-12512\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31753901_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31753901_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1136\/ard.2010.134155\">Valdes, A. M., Evangelou, E., Kerkhof, H. J., Tamm, A., Doherty, S. A., Kisand, K., Tamm, A., Kerna, I., Uitterlinden, A., Hofman, A., Rivadeneira, F., Cooper, C., Dennison, E. M., Zhang, W., Muir, K. R., Ioannidis, J. P., Wheeler, M., Maciewicz, R. A., van Meurs, J. B., Arden, N. K., \u2026 Doherty, M. (2011). The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.\u00a0<em>Annals of the rheumatic diseases<\/em>,\u00a0<em>70<\/em>(5), 873\u2013875. https:\/\/doi.org\/10.1136\/ard.2010.134155<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u4fe1\u983c\u306e\u907a\u4f1d\u5b50\u691c\u67fb<\/p>\n<p class=\"btn\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u819d\u95a2\u7bc0\u75c7\uff08knee osteoarthritis\uff09\u306f\u3001\u4e16\u754c\u4e2d\u306e\u4e2d\u9ad8\u5e74\u5c64\u306b\u591a\u304f\u307f\u3089\u308c\u308b\u6700\u3082\u4e00\u822c\u7684\u306a\u7b4b\u9aa8\u683c\u7cfb\u75be\u60a3\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u95a2\u7bc0\u8edf\u9aa8\u306e\u9032\u884c\u6027\u306e\u5909\u6027\u3001\u9aa8\u306e\u518d\u69cb\u7bc9\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u7279\u5fb4\u3068\u3057\u3001\u6162\u6027\u7684\u306a\u75bc\u75db\u3084 [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":12441,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[237],"tags":[406,262,402,242,405,403,225,404,401,400,408,59,337,36,222,410,409,407],"class_list":["post-12439","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-paper","tag-gdf5","tag-gwas","tag-rs143383","tag-snp","tag-tgf-","tag-403","tag-225","tag-404","tag-401","tag-400","tag-408","tag-59","tag-337","tag-gene-testing","tag-222","tag-410","tag-409","tag-407"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=12439"}],"version-history":[{"count":3,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12439\/revisions"}],"predecessor-version":[{"id":12519,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12439\/revisions\/12519"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/12441"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=12439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=12439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=12439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}