{"id":12520,"date":"2025-04-04T08:42:29","date_gmt":"2025-04-04T08:42:29","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=12520"},"modified":"2025-04-04T08:53:01","modified_gmt":"2025-04-04T08:53:01","slug":"agawnt10a","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/agawnt10a\/","title":{"rendered":"\u7537\u6027\u578b\u8131\u6bdb\u75c7\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u3064\u3044\u306b\u7279\u5b9a\uff1fWNT\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3068\u306e\u610f\u5916\u306a\u95a2\u4fc2\u3068\u306f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<p>\u7537\u6027\u578b\u8131\u6bdb\u75c7\uff08androgenetic alopecia\uff1aAGA\uff09\u306f\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u6700\u3082\u4e00\u822c\u7684\u306a\u8131\u6bdb\u75c7\u3067\u3042\u308a\u3001\u7279\u306b\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u7537\u6027\u3067\u306f80\u6b73\u307e\u3067\u306b\u7d0480\uff05\u304c\u767a\u75c7\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002AGA\u306f\u982d\u9aea\u306e\u9032\u884c\u6027\u306e\u8584\u6bdb\u3092\u7279\u5fb4\u3068\u3057\u3001\u6bdb\u9aea\u306e\u6210\u9577\u5468\u671f\uff08\u30d8\u30a2\u30b5\u30a4\u30af\u30eb\uff09\u306b\u304a\u3051\u308b\u5909\u5316\u3001\u7279\u306b\u6210\u9577\u671f\uff08anagen\uff09\u306e\u77ed\u7e2e\u3068\u4f11\u6b62\u671f\uff08telogen\uff09\u306e\u5ef6\u9577\u304c\u305d\u306e\u4e2d\u5fc3\u7684\u306a\u8981\u56e0\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/25387670_s.jpg\" alt=\"AGA\" class=\"wp-image-12530\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25387670_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/25387670_s-300x169.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>AGA\u306e\u767a\u75c7\u306b\u306f\u8907\u6570\u306e\u56e0\u5b50\u304c\u95a2\u4e0e\u3057\u307e\u3059\u304c\u3001\u907a\u4f1d\u7684\u7d20\u56e0\u3068\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\uff08\u7537\u6027\u30db\u30eb\u30e2\u30f3\uff09\u306e\u5f71\u97ff\u304c\u4e3b\u8981\u306a\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u53cc\u751f\u5150\u7814\u7a76\u306b\u3088\u308a\u3001AGA\u306e\u907a\u4f1d\u7387\u306f\u7d0480\uff05\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u306b\u8907\u6570\u306e\u5019\u88dc\u907a\u4f1d\u5b50\u89e3\u6790\u304a\u3088\u3073\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08genome-wide association study\uff1aGWAS\uff09\u306b\u3088\u3063\u3066\u30018\u3064\u306e\u7570\u306a\u308b\u67d3\u8272\u4f53\u9818\u57df\u306b\u304a\u3051\u308b\u4e00\u5869\u57fa\u591a\u578b\uff08single-nucleotide polymorphism\uff1aSNP\uff09\u3068AGA\u3068\u306e\u6709\u610f\u306a\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001X\u67d3\u8272\u4f53\u4e0a\u306b\u5b58\u5728\u3059\u308b\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\uff08androgen receptor\uff1aAR\uff09\u304a\u3088\u3073EDA2R\uff08ectodysplasin A2 receptor\uff09\u907a\u4f1d\u5b50\u9818\u57df\u3068\u306e\u95a2\u9023\u304c\u6700\u3082\u5f37\u304f\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3084\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u76f4\u63a5\u7684\u306a\u5f71\u97ff\u306f\u307e\u3060\u660e\u78ba\u306b\u306f\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"687\" height=\"551\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P10275-F1-1.png\" alt=\"androgen receptor\" class=\"wp-image-12537\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P10275-F1-1.png 687w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P10275-F1-1-300x241.png 300w\" sizes=\"(max-width: 687px) 100vw, 687px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u305d\u308c\u3067\u3082\u3001\u65e2\u77e5\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u8aac\u660e\u3055\u308c\u308b\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306f\u5168\u4f53\u306e\u4e00\u90e8\u306b\u3068\u3069\u307e\u308a\u3001\u672a\u89e3\u660e\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u4ee5\u524d\u306e\u30e1\u30bf\u89e3\u6790\u306b\u304a\u3044\u3066\u300c\u793a\u5506\u7684\u95a2\u9023\u300d\uff08P\u5024\u304c5 \u00d7 10\u207b\u2078\u301c10\u207b\u2075\u306e\u7bc4\u56f2\uff09\u3092\u793a\u3057\u305fSNP\u7fa4\u306e\u8ffd\u8a66\u3092\u901a\u3058\u3066\u3001\u65b0\u305f\u306a\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u9818\u57df\u306e\u540c\u5b9a\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08\u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated Genes &amp; SNPs<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u904e\u53bb\u306e\u30e1\u30bf\u89e3\u6790\u3067\u793a\u5506\u7684\u306a\u95a2\u9023\uff085 \u00d7 10\u207b\u2078 &lt; P &lt; 10\u207b\u2075\uff09\u304c\u5831\u544a\u3055\u308c\u305f12\u306e\u907a\u4f1d\u5b50\u9818\u57df\u306b\u7740\u76ee\u3057\u3001\u518d\u73fe\u6027\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u4ee5\u4e0b\u306e4\u3064\u306e\u907a\u4f1d\u5b50\u9818\u57df\u304c\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u3067\u7d71\u8a08\u5b66\u7684\u6709\u610f\u6027\uff08P &lt; 5 \u00d7 10\u207b\u2078\uff09\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"736\" height=\"364\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HAV5-F1.png\" alt=\"Tumor necrosis factor receptor superfamily member 27\" class=\"wp-image-12544\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HAV5-F1.png 736w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HAV5-F1-300x148.png 300w\" sizes=\"(max-width: 736px) 100vw, 736px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u7b2c2\u67d3\u8272\u4f53\u9577\u8155\uff082q35\uff09<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/2q35-hgtIdeo_genome_290672_f96850-1024x25.png\" alt=\"2q35\" class=\"wp-image-12552\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2q35-hgtIdeo_genome_290672_f96850-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2q35-hgtIdeo_genome_290672_f96850-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2q35-hgtIdeo_genome_290672_f96850-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2q35-hgtIdeo_genome_290672_f96850.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<p><strong>\u7b2c5\u67d3\u8272\u4f53\u9577\u8155\uff085q33.3\uff09<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/5q33.3-hgtIdeo_genome_295cfb_f96b30-1024x25.png\" alt=\"5q33.3\" class=\"wp-image-12559\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/5q33.3-hgtIdeo_genome_295cfb_f96b30-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/5q33.3-hgtIdeo_genome_295cfb_f96b30-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/5q33.3-hgtIdeo_genome_295cfb_f96b30-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/5q33.3-hgtIdeo_genome_295cfb_f96b30.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<p>SNP\uff1ars929626\uff08P = 2.12 \u00d7 10\u207b\u00b9\u00b9\u3001OR = 0.84\uff09\u304a\u3088\u3073rs1081073\uff08P = 8.52 \u00d7 10\u207b\u2079\u3001OR = 1.17\uff09<\/p>\n\n\n\n<p>\u3044\u305a\u308c\u3082\u521d\u671fB\u7d30\u80de\u56e0\u5b501\uff08EBF1\uff1aearly B-cell factor 1\uff09\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u5185\u306b\u4f4d\u7f6e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u7b2c3\u67d3\u8272\u4f53\u9577\u8155\uff083q25.1\uff09<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3q25.1-hgtIdeo_genome_299930_f96d70-1024x25.png\" alt=\"3q25.1\" class=\"wp-image-12566\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3q25.1-hgtIdeo_genome_299930_f96d70-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3q25.1-hgtIdeo_genome_299930_f96d70-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3q25.1-hgtIdeo_genome_299930_f96d70-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3q25.1-hgtIdeo_genome_299930_f96d70.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<p>SNP\uff1ars7648585\uff08P = 1.79 \u00d7 10\u207b\u00b9\u2070\u3001OR = 1.19\uff09\u3001rs4679955\uff08P = 1.20 \u00d7 10\u207b\u2079\u3001OR = 1.18\uff09<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306f\u3001SUCNR1\uff08succinate receptor 1\uff09\u304a\u3088\u3073MBNL1\uff08muscleblind-like splicing regulator 1\uff09\u3068\u3044\u30462\u3064\u306e\u907a\u4f1d\u5b50\u9593\u306e\u30a4\u30f3\u30bf\u30fc\u30b8\u30a7\u30cb\u30c3\u30af\u9818\u57df\u306b\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u7b2c12\u67d3\u8272\u4f53\u77ed\u8155\uff0812p12.1\uff09<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/12p12.1-hgtIdeo_genome_29cf45_f96ff0-1024x25.png\" alt=\"12p12.1\" class=\"wp-image-12573\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/12p12.1-hgtIdeo_genome_29cf45_f96ff0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/12p12.1-hgtIdeo_genome_29cf45_f96ff0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/12p12.1-hgtIdeo_genome_29cf45_f96ff0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/12p12.1-hgtIdeo_genome_29cf45_f96ff0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<p>SNP\uff1ars9668810\uff08P = 1.09 \u00d7 10\u207b\u00b9\u2070\u3001OR = 1.21\uff09\u3001rs7975017\uff08P = 4.03 \u00d7 10\u207b\u00b9\u2070\u3001OR = 1.21\uff09<\/p>\n\n\n\n<p>\u3044\u305a\u308c\u3082\u3001SSPN\uff08sarcospan\uff09\u3068ITPR2\uff08inositol 1,4,5-triphosphate receptor type 2\uff09\u306e\u9593\u306b\u4f4d\u7f6e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e3b\u8981SNP\uff1ars7349332\uff08P = 3.55 \u00d7 10\u207b\u00b9\u2075\u3001\u30aa\u30c3\u30ba\u6bd4 [odds ratio\uff1aOR] = 1.34\u300195\uff05\u4fe1\u983c\u533a\u9593 [confidence interval\uff1aCI]\uff1a1.27\u20131.42\uff09<\/p>\n\n\n\n<p>\u3053\u306eSNP\u306fWNT10A\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u5185\u306b\u4f4d\u7f6e\u3057\u307e\u3059\u3002WNT10A\u306fWNT\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\u3001\u7d30\u80de\u9593\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3059\u308b\u5206\u6ccc\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u88dc\u8db3SNP\uff1ars10193725\uff08P = 1.46 \u00d7 10\u207b\u00b9\u2070\u3001OR = 0.80\uff09\u306f\u3001rs7349332\u306e\u7d0430 kb\u4e0a\u6d41\u306b\u3042\u308a\u3001WNT6\u907a\u4f1d\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u5185\u306b\u4f4d\u7f6e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001rs7349332\uff08WNT10A\u306b\u4f4d\u7f6e\u3059\u308bSNP\uff09\u306eT\u30a2\u30ec\u30eb\uff08AGA\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff09\u306f\u3001\u72ec\u7acb\u3057\u305f2\u3064\u306eGWAS\u3067\u5dfb\u304d\u6bdb\uff08hair curl\uff09\u3068\u306e\u95a2\u9023\u3082\u793a\u3055\u308c\u3066\u304a\u308a\u3001WNT\u7d4c\u8def\uff08WNT signaling\uff09\u306e\u91cd\u8907\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"740\" height=\"405\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9GZT5-F1.png\" alt=\"WNT10A\" class=\"wp-image-12580\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9GZT5-F1.png 740w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9GZT5-F1-300x164.png 300w\" sizes=\"(max-width: 740px) 100vw, 740px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u540c\u5b9a\u3055\u308c\u305frs7349332\uff082q35\uff09\u306b\u304a\u3051\u308b\u5f37\u3044\u95a2\u9023\u306f\u3001WNT10A\u304cAGA\u306e\u75c5\u56e0\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u907a\u4f1d\u5b66\u7684\u306b\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3059\u3002WNT10A\u306fWNT\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u3067\u3001\u80da\u767a\u751f\u306b\u304a\u3051\u308b\u7d30\u80de\u5206\u5316\u3084\u81d3\u5668\u5f62\u6210\u3001\u307e\u305f\u6210\u4eba\u7d44\u7e54\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u56e0\u5b50\u3092\u30b3\u30fc\u30c9\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"772\" height=\"449\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9GZT5-F1-1.png\" alt=\"WNT10A\" class=\"wp-image-12587\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9GZT5-F1-1.png 772w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9GZT5-F1-1-300x174.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9GZT5-F1-1-768x447.png 768w\" sizes=\"(max-width: 772px) 100vw, 772px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>WNT\u7d4c\u8def\u306e\u8131\u6bdb\u75c7\u3078\u306e\u95a2\u4e0e\u306f\u3001\u904e\u53bb\u306e\u8907\u6570\u306e\u7814\u7a76\u3067\u3082\u6307\u6458\u3055\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u6210\u9577\u671f\uff08anagen\uff09\u3078\u306e\u79fb\u884c\u5236\u5fa1\u306b\u304a\u3051\u308bWNT\u30b7\u30b0\u30ca\u30eb\u306e\u5f79\u5272\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002WNT10A\u306f\u30de\u30a6\u30b9\u6bdb\u5305\u306e\u6210\u9577\u671f\u521d\u671f\u306b\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u30d2\u30c8\u6bdb\u5305\u3067\u3082\u540c\u69d8\u306b\u767a\u73fe\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001rs7349332\u306e\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u3092\u4fdd\u6709\u3059\u308b\u4eba\u3067\u306f\u3001WNT10A\u306e\u767a\u73fe\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08P = 0.03\uff09\u3002\u3053\u308c\u306f\u3001\u4f11\u6b62\u671f\u304b\u3089\u6210\u9577\u671f\u3078\u306e\u79fb\u884c\u304c\u9045\u308c\u305f\u308a\u3001\u6210\u9577\u671f\u304c\u77ed\u7e2e\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3067\u3001AGA\u306b\u304a\u3051\u308b\u30d8\u30a2\u30b5\u30a4\u30af\u30eb\u7570\u5e38\uff08\u6210\u9577\u671f\u6bdb\u5305\u306e\u6e1b\u5c11\u3068\u4f11\u6b62\u671f\u6bdb\u5305\u306e\u5897\u52a0\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"731\" height=\"478\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9ULW2-F1.png\" alt=\"Frizzled-10\" class=\"wp-image-12594\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9ULW2-F1.png 731w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9ULW2-F1-300x196.png 300w\" sizes=\"(max-width: 731px) 100vw, 731px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001FZD10\uff08WNT\u53d7\u5bb9\u4f53\uff09\u3068WNT3\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u907a\u4f1d\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\uff08P = 0.02\uff09\u304c\u691c\u51fa\u3055\u308c\u3066\u304a\u308a\u3001WNT\u7d4c\u8def\u306e\u5e83\u7bc4\u306a\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u81e8\u5e8a\u907a\u4f1d\u5b66\u306e\u89b3\u70b9\u304b\u3089\u3082\u3001WNT10A\u306e\u30db\u30e2\u63a5\u5408\u6027\u5909\u7570\u304c\u758e\u6bdb\u3092\u5448\u3059\u308b\u5e38\u67d3\u8272\u4f53\u52a3\u6027\u75be\u60a3\uff08\u30aa\u30c9\u30f3\u30c8\u30fb\u30aa\u30cb\u30b3\u30fb\u30b8\u30b9\u30d7\u30e9\u30b8\u30a2\uff1aOMIM 257980, OMIM 606268\uff09\u306e\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/FZD10-hgtIdeo_genome_2ccca9_f98c70-1024x25.png\" alt=\"FZD10\" class=\"wp-image-12601\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/FZD10-hgtIdeo_genome_2ccca9_f98c70-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/FZD10-hgtIdeo_genome_2ccca9_f98c70-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/FZD10-hgtIdeo_genome_2ccca9_f98c70-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/FZD10-hgtIdeo_genome_2ccca9_f98c70.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>AGA\u3068\u9aea\u8cea\uff08\u5dfb\u304d\u6bdb\uff09\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u3082\u65b0\u305f\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002rs7349332\u306eT\u30a2\u30ec\u30eb\u306fAGA\u3068\u540c\u6642\u306b\u5dfb\u304d\u6bdb\u3068\u3082\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u304cWNT\u7d4c\u8def\u306b\u7279\u7570\u7684\u306a\u95a2\u9023\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u6b27\u5dde\u7cfb\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u305f2\u3064\u306e\u72ec\u7acb\u3057\u305f\u30b5\u30f3\u30d7\u30eb\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u518d\u73fe\u89e3\u6790 I\uff08Replication I\uff09<\/strong>\uff1a\u30c9\u30a4\u30c4\u4eba\u7537\u6027177\u4f8b\uff08AGA\u3042\u308a\uff09\u304a\u3088\u3073272\u4f8b\uff08AGA\u306a\u3057\uff09\u3092\u5bfe\u8c61\u3002\u6bdb\u9aea\u306e\u72b6\u614b\u306fHamilton\/Norwood\u5206\u985e\u3092\u7528\u3044\u3066\u76ae\u819a\u79d1\u533b\u304c\u8a55\u4fa1\u3002DNA\u62bd\u51fa\u306f\u5869\u6790\u6cd5\u307e\u305f\u306f\u78c1\u6c17\u30d3\u30fc\u30ba\u6cd5\u3092\u7528\u3044\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u518d\u73fe\u89e3\u6790 II\uff08Replication II\uff09<\/strong>\uff1a23andMe\u793e\u306e\u500b\u4eba\u30b2\u30ce\u30e0\u30b5\u30fc\u30d3\u30b9\u53c2\u52a0\u8005\u304b\u3089\u62bd\u51fa\u3055\u308c\u305fAGA\u7537\u60272582\u4f8b\u304a\u3088\u3073\u5bfe\u71672389\u4f8b\u3002\u81ea\u5df1\u7533\u544a\u8abf\u67fb\u306b\u57fa\u3065\u304d\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg\" alt=\"\" class=\"wp-image-11365\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>SNP\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u306f\u3001Replication I\u3067\u306fSequenom MassARRAY\u3001Replication II\u3067\u306fIllumina SNP\u30a2\u30ec\u30a4\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u7cbe\u5ea6\u306f90%\u4ee5\u4e0a\u3092\u57fa\u6e96\u3068\u3057\u3001\u4e0d\u9069\u5408\u30c7\u30fc\u30bf\u306f\u9664\u5916\u3057\u307e\u3057\u305f\u3002SNP\u306e\u30a4\u30f3\u30d4\u30e5\u30c6\u30fc\u30b7\u30e7\u30f3\u306b\u306fBeagle\u304a\u3088\u3073Minimac\u3092\u7528\u3044\u30011,000 Genomes\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9\u3068\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u6bdb\u5305\u7d44\u7e54\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u306f\u300120\uff5e40\u6b73\u306e\u30c9\u30a4\u30c4\u4eba\u7537\u597398\u540d\u304b\u3089\u5f8c\u982d\u90e8\u6bdb\u5305\u3092\u63a1\u53d6\u3057\u3001RNA\u3092\u62bd\u51fa\u30fb\u5897\u5e45\u5f8c\u3001Illumina HT-12v4\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u3092\u7528\u3044\u3066\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002P\u5024&lt;0.01\u3067\u691c\u51fa\u3055\u308c\u305f\u907a\u4f1d\u5b50\u306e\u307f\u300c\u767a\u73fe\u3042\u308a\u300d\u3068\u3057\u3066\u6271\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<p>12\u306e\u793a\u5506\u7684\u306a\u907a\u4f1d\u5b50\u9818\u57df\u304b\u3089\u30014\u3064\u306e\u65b0\u898f\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u6709\u610f\u306aAGA\u95a2\u9023\u9818\u57df\u304c\u78ba\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u3082\u5f37\u3044\u95a2\u9023\u306f2q35\u306ers7349332\u3067\u3001WNT10A\u907a\u4f1d\u5b50\u5185\u306b\u4f4d\u7f6e\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs7349332-hgtIdeo_genome_2d17f0_f99180-1024x25.png\" alt=\"rs7349332\" class=\"wp-image-12608\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7349332-hgtIdeo_genome_2d17f0_f99180-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7349332-hgtIdeo_genome_2d17f0_f99180-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7349332-hgtIdeo_genome_2d17f0_f99180-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs7349332-hgtIdeo_genome_2d17f0_f99180.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>WNT10A\u304a\u3088\u3073ITPR2\u306f\u30d2\u30c8\u6bdb\u5305\u3067\u306e\u767a\u73fe\u304c\u78ba\u8a8d\u3055\u308c\u3001\u7279\u306bWNT10A\u3067\u306fAGA\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u3092\u6301\u3064\u88ab\u9a13\u8005\u3067\u6709\u610f\u306a\u767a\u73fe\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\uff08P = 0.03\uff09\u3002\u4e00\u65b9\u3001\u4ed6\u306e\u5019\u88dc\u907a\u4f1d\u5b50\uff08SUCNR1, EBF1\u306a\u3069\uff09\u3067\u306f\u6bdb\u5305\u3067\u306e\u767a\u73fe\u304c\u78ba\u8a8d\u3055\u308c\u305a\u3001\u3055\u3089\u306a\u308b\u6a5f\u80fd\u7684\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"572\" height=\"605\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9BXA5-F1.png\" alt=\"Succinate receptor 1\" class=\"wp-image-12615\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9BXA5-F1.png 572w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9BXA5-F1-284x300.png 284w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001WNT\u95a2\u9023\u907a\u4f1d\u5b50\u540c\u58eb\u306e\u76f8\u4e92\u4f5c\u7528\u89e3\u6790\u3067\u306f\u3001WNT3\u3068FZD10\u3068\u306e\u9593\u3067\u6709\u610f\u306a\u76f8\u4e92\u4f5c\u7528\uff08P = 0.02\uff09\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u30012q35\uff08WNT10A\uff09\u30013q25.1\u30015q33.3\u300112p12.1\u306e4\u3064\u306e\u907a\u4f1d\u5b50\u9818\u57df\u304cAGA\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u7279\u306bWNT10A\u306f\u3001\u30d2\u30c8\u6bdb\u5305\u3067\u306e\u767a\u73fe\u304cAGA\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u306b\u3088\u3063\u3066\u6291\u5236\u3055\u308c\u3066\u304a\u308a\u3001WNT\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304cAGA\u306e\u767a\u75c7\u6a5f\u69cb\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u3059\u6709\u529b\u306a\u8a3c\u62e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/24513981_s.jpg\" alt=\"\u304a\u3067\u3053\u3067\u305f\" class=\"wp-image-12622\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24513981_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24513981_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>WNT\u7d4c\u8def\u306f\u591a\u304f\u306e\u767a\u751f\u30fb\u518d\u751f\u95a2\u9023\u75be\u60a3\u306b\u3082\u95a2\u4e0e\u3059\u308b\u305f\u3081\u3001\u4eca\u5f8cAGA\u4ee5\u5916\u306e\u75be\u60a3\u3068\u306e\u95a2\u9023\u89e3\u660e\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u30023q25.1\u304a\u3088\u30735q33.3\u306b\u95a2\u3057\u3066\u306f\u3001\u5177\u4f53\u7684\u306a\u8cac\u4efb\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306b\u306f\u81f3\u3063\u3066\u304a\u3089\u305a\u3001\u518d\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3084\u6a5f\u80fd\u7684\u89e3\u6790\u3092\u901a\u3058\u305f\u8ffd\u52a0\u7814\u7a76\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u7537\u6027\u578b\u8131\u6bdb\u75c7, \u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u6027\u8131\u6bdb\u75c7, WNT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054, \u907a\u4f1d\u7684\u95a2\u9023, SNP, GWAS, rs7349332, WNT10A, \u9aea\u306e\u6bdb\u306e\u5468\u671f, \u30d8\u30a2\u30ab\u30fc\u30eb, androgenetic alopecia, male-pattern baldness, WNT signaling, genetic association, SNP, GWAS, rs7349332, WNT10A, hair cycle, hair curl<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32029542_s.jpg\" alt=\"pochi\" class=\"wp-image-11435\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32029542_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32029542_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/jid.2013.43\">Heilmann, S., Kiefer, A. K., Fricker, N., Drichel, D., Hillmer, A. M., Herold, C., Tung, J. Y., Eriksson, N., Redler, S., Betz, R. C., Li, R., K\u00e1rason, A., Nyholt, D. R., Song, K., Vermeulen, S. H., Kanoni, S., Dedoussis, G., Martin, N. G., Kiemeney, L. A., \u2026 N\u00f6then, M. M. (2013). Androgenetic alopecia: Identification of four genetic risk loci and evidence for the contribution of wnt signaling to its etiology.\u00a0<em>Journal of Investigative Dermatology<\/em>,\u00a0<em>133<\/em>(6), 1489\u20131496. https:\/\/doi.org\/10.1038\/jid.2013.43<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u7537\u6027\u578b\u8131\u6bdb\u75c7\uff08androgenetic alopecia\uff1aAGA\uff09\u306f\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u6700\u3082\u4e00\u822c\u7684\u306a\u8131\u6bdb\u75c7\u3067\u3042\u308a\u3001\u7279\u306b\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u7537\u6027\u3067\u306f80\u6b73\u307e\u3067\u306b\u7d0480\uff05\u304c\u767a\u75c7\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002AGA\u306f\u982d [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":12523,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[415,242,412,394,419,418,425,413,411,424,421,423,414,417,422,59,420,416],"class_list":["post-12520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-aga","tag-snp","tag-wnt10a","tag-wnt","tag-419","tag-418","tag-425","tag-413","tag-411","tag-424","tag-421","tag-423","tag-414","tag-417","tag-422","tag-59","tag-420","tag-416"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=12520"}],"version-history":[{"count":4,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12520\/revisions"}],"predecessor-version":[{"id":12629,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12520\/revisions\/12629"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/12523"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=12520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=12520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=12520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}