{"id":12630,"date":"2025-04-04T09:22:36","date_gmt":"2025-04-04T09:22:36","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=12630"},"modified":"2025-04-04T09:23:53","modified_gmt":"2025-04-04T09:23:53","slug":"acnevulgaris","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/acnevulgaris\/","title":{"rendered":"\u30cb\u30ad\u30d3\u306f\u907a\u4f1d\u3059\u308b\uff1f\u6700\u65b0\u7814\u7a76\u3067\u898b\u3048\u305f\u201c\u808c\u8352\u308c\u4f53\u8cea\u201d\u306e\u907a\u4f1d\u5b50\u30ea\u30b9\u30af"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<p>\u5c0b\u5e38\u6027\u3056\u7621\uff08acne vulgaris\uff09\u306f\u3001\u6bdb\u5305\u3068\u305d\u308c\u306b\u4ed8\u968f\u3059\u308b\u76ae\u8102\u817a\u304b\u3089\u306a\u308b\u300c\u6bdb\u5305\u76ae\u8102\u817a\u30e6\u30cb\u30c3\u30c8\uff08pilosebaceous unit\uff09\u300d\u306e\u708e\u75c7\u306b\u3088\u308a\u767a\u75c7\u3059\u308b\u591a\u56e0\u5b50\u7684\u306a\u76ae\u819a\u75be\u60a3\u3067\u3059\u3002\u9762\u76b0\uff08comedone\uff09\u3001\u4e18\u75b9\uff08papule\uff09\u3001\u81bf\u75b1\uff08pustule\uff09\u3001\u786c\u7d50\uff08nodule\uff09\u3001\u56a2\u816b\uff08cyst\uff09\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u76ae\u819a\u75c5\u5909\u3092\u5448\u3057\u307e\u3059\u3002\u7279\u306b\u9854\u9762\u3001\u9838\u90e8\u3001\u80f8\u90e8\u3001\u80cc\u90e8\u306a\u3069\u76ae\u8102\u817a\u304c\u6d3b\u767a\u306a\u90e8\u4f4d\u306b\u597d\u767a\u3057\u3001\u601d\u6625\u671f\u306e\u30db\u30eb\u30e2\u30f3\u5909\u5316\u306b\u4f34\u3063\u3066\u767a\u75c7\u3059\u308b\u306e\u304c\u4e00\u822c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3329714_s.jpg\" alt=\"\u30de\u30b9\u30af\" class=\"wp-image-12757\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3329714_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3329714_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e16\u754c\u7684\u306b\u6700\u3082\u6709\u75c5\u7387\u306e\u9ad8\u3044\u76ae\u819a\u75be\u60a3\u3067\u3042\u308a\u3001\u601d\u6625\u671f\u306e\u7d0485\uff05\u304c\u4f55\u3089\u304b\u306e\u3056\u7621\u3092\u7d4c\u9a13\u3057\u3001\u305d\u306e\u3046\u3061\u7d048\uff05\u304c\u91cd\u75c7\u578b\u3067\u3042\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u30022019\u5e74\u306e\u300c\u4e16\u754c\u75be\u75c5\u8ca0\u8377\uff08Global Burden of Disease, GBD\uff09\u300d\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u3056\u7621\u306f\u5168\u4e16\u754c\u3067\u7d04500\u4e07\u306e\u969c\u5bb3\u8abf\u6574\u751f\u547d\u5e74\uff08disability-adjusted life years, DALYs\uff09\u3092\u3082\u305f\u3089\u3057\u3066\u304a\u308a\u3001\u5bfe\u8c61\u5e74\u9f62\u306e\u4e2d\u5fc3\u306f15\u301c49\u6b73\u3067\u3001\u4e7e\u766c\u3084\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306a\u3069\u4ed6\u306e\u6162\u6027\u708e\u75c7\u6027\u76ae\u819a\u75be\u60a3\u3088\u308a\u3082\u9ad8\u3044\u8ca0\u62c5\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u91cd\u75c7\u3056\u7621\u306f\u7622\u75d5\u5f62\u6210\u3092\u4f34\u3046\u3053\u3068\u304c\u591a\u304f\u3001\u7279\u306b\u6210\u4eba\u3067\u306f\u6c38\u4e45\u7684\u306a\u76ae\u819a\u969c\u5bb3\u306b\u52a0\u3048\u3001\u3046\u3064\u75c5\u3001\u4e0d\u5b89\u969c\u5bb3\u3001\u81ea\u6bba\u5ff5\u616e\u306a\u3069\u306e\u7cbe\u795e\u7684\u5f71\u97ff\u304c\u5f37\u304f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3056\u7621\u306e\u3042\u308b\u82e5\u5e74\u8005\u306f\u3001\u3056\u7621\u306e\u306a\u3044\u540c\u5e74\u4ee3\u3068\u6bd4\u8f03\u3057\u3066\u6700\u59273\u500d\u306e\u7cbe\u795e\u75be\u60a3\u30ea\u30b9\u30af\u304c\u3042\u308b\u3068\u3055\u308c\u3001\u5b66\u696d\u3084\u4ed5\u4e8b\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u4f4e\u4e0b\u3068\u3082\u95a2\u9023\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/22082341_s.jpg\" alt=\"\u307f\u306a\u3044\u3067\" class=\"wp-image-12644\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22082341_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22082341_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e7e\u766c\u3084\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306a\u3069\u306e\u708e\u75c7\u6027\u76ae\u819a\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u898f\u6cbb\u7642\u6cd5\u306f\u9032\u6b69\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3056\u7621\u6cbb\u7642\u306e\u9078\u629e\u80a2\u306f\u4f9d\u7136\u3068\u3057\u3066\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6a19\u6e96\u6cbb\u7642\u306b\u306f\u3001\u5c40\u6240\u3042\u308b\u3044\u306f\u5168\u8eab\u6027\u306e\u6297\u83cc\u85ac\u3001\u30ec\u30c1\u30ce\u30a4\u30c9\u3001\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u3001\u5149\u7dda\u7642\u6cd5\u306a\u3069\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u4e2d\u3067\u3082\u6700\u3082\u52b9\u679c\u7684\u3068\u3055\u308c\u308b\u306e\u304c\u30a4\u30bd\u30c8\u30ec\u30c1\u30ce\u30a4\u30f3\uff08isotretinoin\uff09\u3067\u3042\u308a\u3001\u8868\u76ae\u5206\u5316\u306e\u6b63\u5e38\u5316\u3068\u76ae\u8102\u5206\u6ccc\u306e\u6291\u5236\u3092\u901a\u3058\u3066\u5bdb\u89e3\u3092\u5c0e\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u53e3\u5507\u708e\u3084\u76ae\u819a\u306e\u4e7e\u71e5\u3001\u7b4b\u8089\u75db\u3001\u982d\u75db\u3068\u3044\u3063\u305f\u526f\u4f5c\u7528\u304c\u3042\u308a\u3001\u3055\u3089\u306b\u50ac\u5947\u5f62\u6027\uff08teratogenicity\uff09\u3082\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u91cd\u75c7\u4f8b\u306b\u9650\u5b9a\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3088\u308a\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u306a\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u306e\u958b\u767a\u304c\u55ab\u7dca\u306e\u8ab2\u984c\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3021992_s.jpg\" alt=\"\u3075\u305f\u3054\" class=\"wp-image-12276\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3021992_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3021992_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u53cc\u751f\u5150\u7814\u7a76\u3067\u306f\u3001\u3056\u7621\u306e\u7f79\u60a3\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u7684\u5bc4\u4e0e\u7387\uff08\u907a\u4f1d\u7387\uff09\u306f\u7d0480\uff05\u3068\u4e00\u8cab\u3057\u3066\u9ad8\u304f\u3001\u660e\u78ba\u306a\u907a\u4f1d\u7684\u80cc\u666f\u304c\u5b58\u5728\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u884c\u308f\u308c\u305f\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08Genome-Wide Association Study, GWAS\uff09\u3067\u306f\u3001\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u96c6\u56e3\u306b\u304a\u3044\u306615\u30ab\u6240\u3001\u6f22\u6c11\u65cf\u306b\u304a\u3044\u30662\u30ab\u6240\u3001\u8a0817\u30ab\u6240\u306e\u95a2\u9023\u907a\u4f1d\u5b50\u5ea7\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3056\u7621\u306e\u907a\u4f1d\u7684\u5168\u4f53\u50cf\u306f\u672a\u89e3\u660e\u306e\u307e\u307e\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated Genes &amp; SNPs<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u8a0843\u306e\u907a\u4f1d\u5b50\u5ea7\u306b\u304a\u3044\u306646\u306e\u72ec\u7acb\u3057\u305f\u4e00\u5869\u57fa\u591a\u578b\uff08SNP: Single Nucleotide Polymorphism\uff09\u304c\u3056\u7621\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3001\u305d\u306e\u3046\u306129\u5ea7\u306f\u65b0\u898f\u306b\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u65e2\u5831\u306e17\u5ea7\u306e\u3046\u306114\u5ea7\u306b\u304a\u3044\u3066\u95a2\u9023\u3092\u518d\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31753903_s-1.jpg\" alt=\"\u30d5\u30a7\u30b9\" class=\"wp-image-12700\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31753903_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31753903_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4ee3\u8868\u7684\u306aSNP\u3068\u95a2\u9023\u907a\u4f1d\u5b50\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3067\u3059\uff1a<\/p>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00-1024x25.png\" alt=\"rs1256580\" class=\"wp-image-12651\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs1256580\uff08TGFB2\u907a\u4f1d\u5b50\u30011q41\uff09<\/strong>\uff1a\u5f8c\u65b9\u78ba\u7387\uff08posterior probability\uff090.9962\u3068\u975e\u5e38\u306b\u9ad8\u304f\u3001\u539f\u56e0\u5019\u88dc\u5909\u7570\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002TGFB2\u306f\u300cTransforming Growth Factor Beta 2\u300d\u306e\u7565\u3067\u3001\u4e0a\u76ae\u7d44\u7e54\u306e\u6210\u9577\u3084\u5206\u5316\u3092\u5236\u5fa1\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3059\u3002\u76ae\u819a\u30d0\u30ea\u30a2\u306e\u5f62\u6210\u3084\u5275\u50b7\u6cbb\u7652\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs260643-hgtIdeo_genome_38ced9_fa0fb0-1024x25.png\" alt=\"rs260643\" class=\"wp-image-12658\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs260643-hgtIdeo_genome_38ced9_fa0fb0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs260643-hgtIdeo_genome_38ced9_fa0fb0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs260643-hgtIdeo_genome_38ced9_fa0fb0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs260643-hgtIdeo_genome_38ced9_fa0fb0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs260643\uff08EDAR\u907a\u4f1d\u5b50\u30012q12.3\uff09<\/strong>\uff1a\u5f8c\u65b9\u78ba\u73870.9581\u3067\u3001\u30a4\u30f3\u30c8\u30ed\u30f3\u5185\u306e\u8ee2\u5199\u56e0\u5b50\u7d50\u5408\u90e8\u4f4d\u306b\u4f4d\u7f6e\u3057\u307e\u3059\u3002EDAR\uff08Ectodysplasin A Receptor\uff09\u306f\u6bdb\u9aea\u3001\u6c57\u817a\u3001\u6b6f\u306a\u3069\u306e\u5916\u80da\u8449\u7531\u6765\u7d44\u7e54\u306e\u5f62\u6210\u306b\u5fc5\u8981\u3067\u3001\u907a\u4f1d\u6027\u75be\u60a3\u300c\u5916\u80da\u8449\u5f62\u6210\u7570\u5e38\u75c7\uff08ectodermal dysplasia\uff09\u300d\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u306eSNP\u306f\u9aea\u306e\u30ab\u30fc\u30eb\u3068\u3082\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u591a\u9762\u7684\u8868\u73fe\u578b\uff08pleiotropy\uff09\u3092\u793a\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs74333950-hgtIdeo_genome_25f008_fa11d0-1024x25.png\" alt=\"rs74333950\" class=\"wp-image-12665\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs74333950-hgtIdeo_genome_25f008_fa11d0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs74333950-hgtIdeo_genome_25f008_fa11d0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs74333950-hgtIdeo_genome_25f008_fa11d0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs74333950-hgtIdeo_genome_25f008_fa11d0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs74333950\uff08WNT10A\u907a\u4f1d\u5b50\u30012q35\uff09<\/strong>\uff1aWNT\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u6bdb\u5305\u306e\u767a\u751f\u3084\u76ae\u8102\u817a\u6a5f\u80fd\u306e\u8abf\u6574\u306b\u91cd\u8981\u3067\u3059\u3002\u8131\u6bdb\u75c7\u3001\u9aea\u8cea\u3001\u5916\u80da\u8449\u5f62\u6210\u7570\u5e38\u3068\u306e\u95a2\u9023\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs6842241-hgtIdeo_genome_262cbf_fa1470-1024x25.png\" alt=\"rs6842241\" class=\"wp-image-12672\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6842241-hgtIdeo_genome_262cbf_fa1470-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6842241-hgtIdeo_genome_262cbf_fa1470-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6842241-hgtIdeo_genome_262cbf_fa1470-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6842241-hgtIdeo_genome_262cbf_fa1470.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs6842241\uff08EDNRA\u907a\u4f1d\u5b50\u8fd1\u508d\u30014q31.22\uff09<\/strong>\uff1a\u3053\u306e\u5909\u7570\u306e\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\uff08risk allele\uff09\u306fEDNRA\uff08\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3\u53d7\u5bb9\u4f53A\u578b\uff09\u306e\u767a\u73fe\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3001\u5f8c\u65b9\u78ba\u7387\u306f0.98\u3067\u3059\u3002EDNRA\u306e\u6a5f\u80fd\u7570\u5e38\u306f\u300c\u984e\u9854\u9762\u7570\u5f62\u6210\uff08mandibulofacial dysostosis\uff09\u300d\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8131\u6bdb\u3092\u4f34\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs17265703-hgtIdeo_genome_269672_fa1740-1024x25.png\" alt=\"rs17265703\" class=\"wp-image-12679\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs17265703-hgtIdeo_genome_269672_fa1740-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs17265703-hgtIdeo_genome_269672_fa1740-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs17265703-hgtIdeo_genome_269672_fa1740-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs17265703-hgtIdeo_genome_269672_fa1740.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs17265703\uff08CSTA\u907a\u4f1d\u5b50\u30013q21.1\uff09<\/strong>\uff1aCSTA\uff08Cystatin A\uff09\u306f\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u963b\u5bb3\u56e0\u5b50\u3067\u3001\u76ae\u819a\u7d30\u80de\u9593\u63a5\u7740\u3092\u7dad\u6301\u3057\u307e\u3059\u3002\u767a\u73fe\u4f4e\u4e0b\u306b\u3088\u308a\u89d2\u5316\u7570\u5e38\u3084\u76ae\u819a\u5265\u96e2\u3092\u8d77\u3053\u3057\u3001\u5265\u96e2\u6027\u76ae\u819a\u75c7\u5019\u7fa4\uff08peeling skin syndrome\uff09\u306e\u539f\u56e0\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:14px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs6735739-hgtIdeo_genome_26d68f_fa1960-1024x25.png\" alt=\"rs6735739\" class=\"wp-image-12686\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6735739-hgtIdeo_genome_26d68f_fa1960-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6735739-hgtIdeo_genome_26d68f_fa1960-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6735739-hgtIdeo_genome_26d68f_fa1960-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs6735739-hgtIdeo_genome_26d68f_fa1960.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs6735739\uff08IL36RN\u907a\u4f1d\u5b50\u8fd1\u508d\u30012q13\uff09<\/strong>\uff1a\u3053\u306eSNP\u306fIL36RN\u306e\u76ae\u819a\u306b\u304a\u3051\u308beQTL\uff08\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u3068SNP\u306e\u95a2\u9023\uff09\u3068\u5171\u5c40\u5728\u3057\u3001\u767a\u73fe\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002IL36RN\u306f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u62ee\u6297\u56e0\u5b50\u3067\u3001\u7a00\u306a\u5909\u7570\u306f\u81bf\u75b1\u6027\u4e7e\u766c\uff08pustular psoriasis\uff09\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u305d\u306e\u4ed6\u3001\u7d30\u80de\u63a5\u7740\u3001\u514d\u75ab\u5fdc\u7b54\u3001\u4e0a\u76ae\u5206\u5316\u306b\u95a2\u4e0e\u3059\u308b\u591a\u304f\u306e\u907a\u4f1d\u5b50\uff08LAMC2, LGR6, GLI2, PRDM1, FGF10\u306a\u3069\uff09\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3056\u7621\u306e\u75c5\u614b\u306b\u306f\u76ae\u819a\u69cb\u9020\u3068\u514d\u75ab\u306e\u53cc\u65b9\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4373847_s.jpg\" alt=\"minaide\" class=\"wp-image-12693\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4373847_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4373847_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001\u3056\u7621\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u5ea7\u306e\u540c\u5b9a\u6570\u3092\u5f93\u6765\u306e4\u500d\u306b\u62e1\u5927\u3057\u305f\u70b9\u3067\u3001\u907a\u4f1d\u7684\u7406\u89e3\u306b\u5927\u304d\u306a\u9032\u5c55\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002\u7279\u306bEDAR\u304a\u3088\u3073WNT10A\u3068\u3044\u3063\u305f\u6bdb\u5305\u306e\u69cb\u9020\u3068\u5206\u5316\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u5ea7\u304c\u5f37\u304f\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u76ae\u819a\u304a\u3088\u3073\u76ae\u8102\u817a\u306e\u5f62\u614b\u7684\u7279\u6027\u304c\u3056\u7621\u306e\u767a\u75c7\u306b\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"488\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1-1024x488.png\" alt=\"Tumor necrosis factor receptor superfamily member EDAR\" class=\"wp-image-12707\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1-1024x488.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1-300x143.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1-768x366.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1.png 1046w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001IL36RN\u3092\u542b\u3080\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u306f\u81bf\u75b1\u6027\u4e7e\u766c\u306a\u3069\u306e\u81ea\u5df1\u708e\u75c7\u6027\u76ae\u819a\u75be\u60a3\u3068\u3082\u5171\u901a\u3059\u308b\u7d4c\u8def\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u3056\u7621\u304c\u708e\u75c7\u6027\u75be\u60a3\u306e\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u4e0a\u306b\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"670\" height=\"584\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UBH0-F1.png\" alt=\"Interleukin-36 receptor antagonist protein\" class=\"wp-image-12714\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UBH0-F1.png 670w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UBH0-F1-300x261.png 300w\" sizes=\"(max-width: 670px) 100vw, 670px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u3056\u7621\u3068\u4ee5\u4e0b\u306e\u75be\u60a3\u30fb\u8868\u73fe\u578b\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u907a\u4f1d\u7684\u76f8\u95a2\uff08genetic correlation\uff09\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30af\u30ed\u30fc\u30f3\u75c5\uff08Crohn&#8217;s disease\uff09\uff1a\u76f8\u95a2\u4fc2\u6570rg = 0.19<\/li>\n\n\n\n<li>\u7d71\u5408\u5931\u8abf\u75c7\uff08schizophrenia\uff09\uff1arg = 0.18<\/li>\n\n\n\n<li>\u4e73\u304c\u3093\uff08breast cancer\uff09\uff1arg = 0.16<\/li>\n\n\n\n<li>\u53cc\u6975\u6027\u969c\u5bb3\uff08bipolar disorder\uff09\uff1arg = 0.12<\/li>\n\n\n\n<li>\u6162\u6027\u75bc\u75db\uff08\u982d\u75db\u3001\u95a2\u7bc0\u75db\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u30db\u30eb\u30e2\u30f3\u5fdc\u7b54\u3001\u514d\u75ab\u7cfb\u3001\u795e\u7d4c\u7cbe\u795e\u6a5f\u80fd\u306a\u3069\u3001\u3056\u7621\u306e\u767a\u75c7\u306b\u591a\u69d8\u306a\u751f\u7269\u5b66\u7684\u7d4c\u8def\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3458586_s.jpg\" alt=\"\u4eba\u7a2e\u6ca2\u5c71\u3042\u308a\u307e\u3059\" class=\"wp-image-12389\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3458586_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3458586_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u306a\u304a\u3001\u4e2d\u56fd\u30fb\u6f22\u6c11\u65cf\u306b\u304a\u3044\u3066\u5831\u544a\u3055\u308c\u305f2\u3064\u306eSNP\uff081q24.2\u300111p11.2\uff09\u306f\u672c\u7814\u7a76\u3067\u306f\u518d\u73fe\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u4eba\u7a2e\u9593\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306e\u9055\u3044\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u975e\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u96c6\u56e3\u306b\u304a\u3051\u308b\u7814\u7a76\u306e\u5fc5\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u305f9\u3064\u306e\u72ec\u7acb\u3057\u305f\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u304b\u308914\u306eGWAS\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3092\u7d71\u5408\u3057\u305f\u30e1\u30bf\u89e3\u6790\u3067\u3059\u3002\u3056\u7621\u306e\u5b9a\u7fa9\u306f\u3001\u76ae\u819a\u79d1\u533b\u306b\u3088\u308b\u8a3a\u65ad\u3001\u96fb\u5b50\u30ab\u30eb\u30c6\u306e\u75c5\u540d\u30b3\u30fc\u30c9\u3001\u3042\u308b\u3044\u306f\u81ea\u5df1\u7533\u544a\u306e\u3044\u305a\u308c\u304b\u3067\u5224\u5b9a\u3055\u308c\u3001\u75c7\u4f8b20,165\u4f8b\u3001\u5bfe\u7167\u7fa4595,231\u4f8b\u3001\u5408\u8a08615,396\u4eba\u304c\u89e3\u6790\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg\" alt=\"\" class=\"wp-image-11365\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u89e3\u6790\u306f\u4ee5\u4e0b\u306e\u624b\u9806\u3067\u884c\u308f\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e1\u30bf\u89e3\u6790<\/strong>\uff1aMETAL\u3092\u7528\u3044\u305f\u9006\u5206\u6563\u52a0\u91cd\u6cd5\u306b\u3088\u308a\u89e3\u6790\u3002MAF\uff08\u6700\u5c0f\u5bfe\u7acb\u907a\u4f1d\u5b50\u983b\u5ea6\uff091\uff05\u672a\u6e80\u304a\u3088\u3073\u30a4\u30f3\u30d4\u30e5\u30c6\u30fc\u30b7\u30e7\u30f3\u7cbe\u5ea60.7\u672a\u6e80\u306eSNP\u3092\u9664\u5916\u3057\u30019\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u4ee5\u4e0a\u3067\u691c\u51fa\u3055\u308c\u305f\u7d04707\u4e07SNP\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u30d5\u30a1\u30a4\u30f3\u30de\u30c3\u30d4\u30f3\u30b0<\/strong>\uff1aWakefield\u306e\u8fd1\u4f3c\u30d9\u30a4\u30ba\u56e0\u5b50\uff08Approximate Bayes Factor\uff09\u3092\u7528\u3044\u3066\u5404\u5ea7\u306e\u539f\u56e0\u5019\u88dcSNP\u3092\u7279\u5b9a\u3057\u300195\uff05\u306e\u78ba\u7387\u3067\u771f\u306e\u539f\u56e0\u5909\u7570\u3092\u542b\u3080\u300c\u30af\u30ec\u30c7\u30a3\u30d6\u30eb\u30bb\u30c3\u30c8\uff08credible set\uff09\u300d\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u5171\u5c40\u5728\u89e3\u6790\uff08Colocalisation\uff09<\/strong>\uff1aGTEx\uff08Genotype-Tissue Expression\uff09v8\u306e\u76ae\u819a\u7d44\u7e54\u306b\u304a\u3051\u308beQTL\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3001coloc\u30d1\u30c3\u30b1\u30fc\u30b8\u306b\u3088\u308aGWAS\u4fe1\u53f7\u3068eQTL\u4fe1\u53f7\u306e\u91cd\u306a\u308a\u3092\u691c\u8a3c\u3002\u5f8c\u65b9\u78ba\u73870.5\u8d85\u3092\u6709\u610f\u306a\u5171\u5c40\u5728\u3068\u5b9a\u7fa9\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u7387\u3068\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\uff08Polygenic Risk Score, PRS\uff09<\/strong>\uff1aLD\u30b9\u30b3\u30a2\u56de\u5e30\u306b\u3088\u308aSNP\u30d9\u30fc\u30b9\u907a\u4f1d\u7387\uff08h\u00b2_SNP\uff09\u3092\u63a8\u5b9a\u3002\u3055\u3089\u306b\u72ec\u7acb\u30b3\u30db\u30fc\u30c8\uff08PISA\u7814\u7a76\u3001N = 2,058\uff09\u3092\u7528\u3044\u3066\u3001PRS\u306e\u3056\u7621\u4e88\u6e2c\u80fd\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31473475_s.jpg\" alt=\"\u7b11\u9854\" class=\"wp-image-12721\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31473475_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31473475_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"416\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32186194_s.jpg\" alt=\"\u7d50\u679c\u5206\u6790\" class=\"wp-image-12728\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32186194_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32186194_s-300x195.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GWAS\u7d50\u679c<\/strong>\uff1a\u5168\u4f53\u306743\u5ea7\u300146\u500b\u306e\u72ec\u7acb\u3057\u305fSNP\u304c\u3056\u7621\u3068\u6709\u610f\u306b\u95a2\u9023\uff08P &lt; 5\u00d710\u207b\u2078\uff09\u3002\u3046\u306129\u5ea7\u306f\u65b0\u898f\u306b\u540c\u5b9a\u3002<\/li>\n\n\n\n<li><strong>\u518d\u73fe\u6027<\/strong>\uff1a\u65e2\u5831\u306e17\u5ea7\u306e\u3046\u306114\u5ea7\u3067\u518d\u73fe\u3002\u6f22\u6c11\u65cf\u7531\u6765\u306e2\u5ea7\uff081q24.2\u300111p11.2\uff09\u306f\u518d\u73fe\u3055\u308c\u305a\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u7387<\/strong>\uff1a\n<ul class=\"wp-block-list\">\n<li>GWAS\u6709\u610fSNP\u306b\u3088\u308b\u3056\u7621\u306e\u8cac\u4efb\u5272\u5408\uff1a6.01\uff05<\/li>\n\n\n\n<li>\u7dcfSNP\u30d9\u30fc\u30b9\u907a\u4f1d\u7387\uff08h\u00b2_SNP\uff09\uff1a22.95\uff05\uff08\u6a19\u6e96\u8aa4\u5dee0.02\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2<\/strong>\uff1a\n<ul class=\"wp-block-list\">\n<li>\u6709\u610fSNP\u306b\u57fa\u3065\u304fPRS\u306f2.8\uff05\uff08\u6a19\u6e96\u8aa4\u5dee1.32\uff05\uff09\u3092\u8aac\u660e\u3002<\/li>\n\n\n\n<li>SBayesR\u6cd5\u3067\u306f5.6\uff05\uff08\u6a19\u6e96\u8aa4\u5dee1.79\uff05\uff09\u3092\u8aac\u660e\u3002<\/li>\n\n\n\n<li>\u4e2d\u7b49\u5ea6\uff5e\u91cd\u75c7\u3056\u7621\u7fa4\u306f\u7121\u75c7\u72b6\u7fa4\u306b\u6bd4\u3079\u3001\u5e73\u5747PRS\u304c\u6709\u610f\u306b\u9ad8\u3044\uff08P = 2.4\u00d710\u207b\u00b9\u00b3, P = 1.6\u00d710\u207b\u00b9\u2076\uff09\u3002<\/li>\n\n\n\n<li>\u91cd\u75c7\u4f8b\u3067\u306e\u4e88\u6e2c\u7cbe\u5ea6\uff08AUC\uff09\u306f0.719\u3068\u6700\u9ad8\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001\u3056\u7621\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u5927\u898f\u6a21\u306b\u660e\u3089\u304b\u306b\u3057\u3001\u75be\u60a3\u95a2\u9023\u5ea7\u306e\u6570\u309246\u306b\u62e1\u5927\u3057\u307e\u3057\u305f\u3002\u6bdb\u5305\u3084\u4e0a\u76ae\u69cb\u9020\u306e\u767a\u751f\u7dad\u6301\u3001\u514d\u75ab\u5fdc\u7b54\u306b\u95a2\u4e0e\u3059\u308b\u591a\u6570\u306e\u907a\u4f1d\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3056\u7621\u304c\u76ae\u819a\u69cb\u9020\u7570\u5e38\u3068\u6162\u6027\u708e\u75c7\u306e\u4e21\u9762\u304b\u3089\u5f62\u6210\u3055\u308c\u308b\u591a\u56e0\u5b50\u75be\u60a3\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32128392_s-3.jpg\" alt=\"\u306f\u3060\" class=\"wp-image-12735\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32128392_s-3.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32128392_s-3-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u7cbe\u795e\u75be\u60a3\u3084\u30db\u30eb\u30e2\u30f3\u95a2\u9023\u75be\u60a3\uff08\u4e73\u304c\u3093\u306a\u3069\uff09\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u306e\u907a\u4f1d\u7684\u95a2\u9023\u3082\u660e\u78ba\u3068\u306a\u308a\u3001\u3056\u7621\u304c\u5358\u306a\u308b\u76ae\u819a\u75c5\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u5168\u8eab\u7684\u306a\u751f\u7269\u5b66\u7684\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\u306e\u4e88\u6e2c\u529b\u306f\u9650\u5b9a\u7684\u306a\u304c\u3089\u3082\u3001\u91cd\u75c7\u4f8b\u3067\u306e\u4e88\u6e2c\u7cbe\u5ea6\u304c\u9ad8\u304f\u3001\u4eca\u5f8c\u306e\u4e88\u9632\u7684\u30b1\u30a2\u3084\u500b\u5225\u5316\u533b\u7642\uff08precision medicine\uff09\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u4eca\u5f8c\u306f\u3088\u308a\u591a\u69d8\u306a\u4eba\u7a2e\u30fb\u5e74\u9f62\u30fb\u6027\u5225\u306b\u304a\u3051\u308b\u7814\u7a76\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32045624_s-1.jpg\" alt=\"\u306f\u3060\" class=\"wp-image-12742\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32045624_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32045624_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u4e00\u5869\u57fa\u591a\u578b, \u30a2\u30af\u30cd, \u30cb\u30ad\u30d3, GWAS, \u591a\u56e0\u5b50\u6027\u75be\u60a3, \u7cbe\u5bc6\u533b\u7642, \u30a8\u30f3\u30c9\u30bb\u30ea\u30f3\u53d7\u5bb9\u4f53, \u8102\u817a, \u30db\u30eb\u30e2\u30f3, \u6bdb\u5305, \u7cbe\u795e\u75be\u60a3, \u6162\u6027\u708e\u75c7, \u591a\u578b, \u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2, single nucleotide polymorphism, acne, GWAS, polygenic disorder, precision medicine, endothelin receptor, sebaceous gland, hormone, hair follicle, psychiatric disorder, chronic inflammation, polymorphism, polygenic score<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32158626_s.jpg\" alt=\"\u306a\u3093\u3067\u3084\" class=\"wp-image-12749\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32158626_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32158626_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41467-022-28252-5\">Mitchell, B.L., Saklatvala, J.R., Dand, N.\u00a0<em>et al.<\/em>\u00a0Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.\u00a0<em>Nat Commun<\/em>\u00a0<strong>13<\/strong>, 702 (2022). https:\/\/doi.org\/10.1038\/s41467-022-28252-5<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u5c0b\u5e38\u6027\u3056\u7621\uff08acne vulgaris\uff09\u306f\u3001\u6bdb\u5305\u3068\u305d\u308c\u306b\u4ed8\u968f\u3059\u308b\u76ae\u8102\u817a\u304b\u3089\u306a\u308b\u300c\u6bdb\u5305\u76ae\u8102\u817a\u30e6\u30cb\u30c3\u30c8\uff08pilosebaceous unit\uff09\u300d\u306e\u708e\u75c7\u306b\u3088\u308a\u767a\u75c7\u3059\u308b\u591a\u56e0\u5b50\u7684\u306a\u76ae\u819a\u75be\u60a3\u3067\u3059\u3002\u9762\u76b0\uff08c [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":12634,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[440,446,434,441,262,442,242,445,412,426,439,431,428,443,449,435,429,430,225,432,436,437,427,433,447,444,438,59,448,274],"class_list":["post-12630","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-acne","tag-acne-vulgaris","tag-csta","tag-edar","tag-gwas","tag-il36rn","tag-snp","tag-tgfb2","tag-wnt10a","tag-426","tag-439","tag-431","tag-428","tag-443","tag-449","tag-435","tag-429","tag-430","tag-225","tag-432","tag-436","tag-437","tag-427","tag-433","tag-447","tag-444","tag-438","tag-59","tag-448","tag-274"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=12630"}],"version-history":[{"count":8,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12630\/revisions"}],"predecessor-version":[{"id":12764,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12630\/revisions\/12764"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/12634"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=12630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=12630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=12630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}