{"id":12630,"date":"2025-04-04T09:22:36","date_gmt":"2025-04-04T09:22:36","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=12630"},"modified":"2026-07-18T01:46:29","modified_gmt":"2026-07-18T01:46:29","slug":"acnevulgaris","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/acnevulgaris\/","title":{"rendered":"\u30cb\u30ad\u30d3\u306f\u907a\u4f1d\u3059\u308b\uff1f\u6700\u65b0\u7814\u7a76\u3067\u898b\u3048\u305f\u201c\u808c\u8352\u308c\u4f53\u8cea\u201d\u306e\u907a\u4f1d\u5b50\u30ea\u30b9\u30af"},"content":{"rendered":"\n<div class=\"wp-block-group\" style=\"border-color:#e8734a;border-width:2px;border-radius:10px;padding-top:20px;padding-right:22px;padding-bottom:20px;padding-left:22px\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n\n<p><strong>\ud83d\udccc \u3053\u306e\u8a18\u4e8b\u3067\u308f\u304b\u308b\u3053\u3068<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30cb\u30ad\u30d3\u30fb\u808c\u8352\u308c\u4f53\u8cea\u304c\u300c\u907a\u4f1d\u3059\u308b\u300d\u3068\u3044\u3048\u308b\u79d1\u5b66\u7684\u6839\u62e0\uff08\u53cc\u5b50\u7814\u7a76\u3067\u907a\u4f1d\u7387\u306f\u7d0480\uff05\uff09<\/li>\n\n\n\n<li>\u30cb\u30ad\u30d3\u306e\u767a\u75c7\u306b\u95a2\u308f\u308b\u4ee3\u8868\u7684\u306a\u907a\u4f1d\u5b50\u3068SNP\uff08TGFB2\u30fbEDAR\u306a\u306946\u30ab\u6240\uff09<\/li>\n\n\n\n<li>\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u3042\u3063\u3066\u3082\u3001\u751f\u6d3b\u7fd2\u6163\u3068\u76ae\u819a\u79d1\u30b1\u30a2\u3067\u808c\u8352\u308c\u3092\u6539\u5584\u3067\u304d\u308b\u7406\u7531<\/li>\n\n\n\n<li>\u300c\u3046\u3061\u306f\u5bb6\u65cf\u307f\u3093\u306a\u808c\u304c\u5f31\u3044\u300d\u3092\u79d1\u5b66\u7684\u306b\u7406\u89e3\u3057\u3001\u4eca\u65e5\u304b\u3089\u59cb\u3081\u3089\u308c\u308b\u5bfe\u7b56<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p>\u300c\u30cb\u30ad\u30d3\u304c\u3067\u304d\u3084\u3059\u3044\u4f53\u8cea\u3063\u3066\u907a\u4f1d\u3059\u308b\u306e\uff1f\u300d\u2014\u2014\u89aa\u5b50\u3067\u30cb\u30ad\u30d3\u3084\u808c\u8352\u308c\u306b\u60a9\u3080\u65b9\u304b\u3089\u3001\u79c1\u304c\u3088\u304f\u53d7\u3051\u308b\u8cea\u554f\u3067\u3059\u3002\u7d50\u8ad6\u304b\u3089\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002<strong>\u30cb\u30ad\u30d3\u30fb\u808c\u8352\u308c\u306e\u306a\u308a\u3084\u3059\u3055\u306b\u306f\u5f37\u3044\u907a\u4f1d\u7684\u80cc\u666f\u304c\u3042\u308a\u3001\u53cc\u5b50\u7814\u7a76\u3067\u306f\u907a\u4f1d\u7387\u304c\u7d0480\uff05\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<\/strong>\u3002\u305f\u3060\u3057\u907a\u4f1d\u306f\u300c\u306a\u308a\u3084\u3059\u3055\u300d\u3092\u6c7a\u3081\u308b\u3060\u3051\u3002\u751f\u6d3b\u7fd2\u6163\u3084\u9069\u5207\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3001\u76ae\u819a\u79d1\u3067\u306e\u6cbb\u7642\u306b\u3088\u3063\u3066\u3001\u808c\u306e\u72b6\u614b\u306f\u5341\u5206\u306b\u5909\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8a18\u4e8b\u3067\u306f\u30012022\u5e74\u306b\u767a\u8868\u3055\u308c\u305f61\u4e07\u4eba\u898f\u6a21\u306e\u6700\u65b0\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u3082\u3068\u306b\u3001\u30cb\u30ad\u30d3\u30fb\u808c\u8352\u308c\u4f53\u8cea\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u3092\u3001\u5c02\u9580\u7528\u8a9e\u3092\u304b\u307f\u304f\u3060\u304d\u306a\u304c\u3089\u89e3\u8aac\u3057\u307e\u3059\u3002\u8aad\u307f\u7d42\u3048\u308b\u9803\u306b\u306f\u3001\u5bb6\u65cf\u306e\u808c\u8cea\u306b\u3068\u3089\u308f\u308c\u305a\u300c\u81ea\u5206\u306b\u5408\u3063\u305f\u5bfe\u7b56\u300d\u3092\u9078\u3079\u308b\u306f\u305a\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30cb\u30ad\u30d3\u30fb\u808c\u8352\u308c\u4f53\u8cea\u306f\u907a\u4f1d\u3059\u308b\uff1f\u53cc\u5b50\u7814\u7a76\u304c\u793a\u3059\u907a\u4f1d\u738780\uff05<\/h2>\n\n\n\n<p><strong>\u30cb\u30ad\u30d3\u306e\u306a\u308a\u3084\u3059\u3055\u306f\u3001\u53cc\u5b50\u7814\u7a76\u3067\u907a\u4f1d\u7387\u304c\u7d0480\uff05\u3068\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u4f53\u8cea\u306e\u5927\u90e8\u5206\u304c\u907a\u4f1d\u3067\u8aac\u660e\u3067\u304d\u307e\u3059\u3002<\/strong>\u3053\u308c\u306f\u8eab\u9577\u3084\u4f53\u91cd\u306e\u907a\u4f1d\u7387\u306b\u3082\u5339\u6575\u3059\u308b\u9ad8\u3055\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5c0b\u5e38\u6027\u3056\u7621\uff08acne vulgaris\uff09\u306f\u3001\u6bdb\u7a74\u3068\u76ae\u8102\u817a\u304b\u3089\u306a\u308b\u300c\u6bdb\u5305\u76ae\u8102\u817a\u30e6\u30cb\u30c3\u30c8\uff08pilosebaceous unit\uff09\u300d\u306e\u708e\u75c7\u3067\u8d77\u3053\u308b\u3001\u591a\u304f\u306e\u8981\u56e0\u304c\u304b\u3089\u307f\u5408\u3046\u76ae\u819a\u75be\u60a3\u3067\u3059\u3002\u9762\u76b0\uff08\u30b3\u30e1\u30c9\uff09\u3001\u8d64\u3044\u4e18\u75b9\u3001\u81bf\u3092\u3082\u3063\u305f\u81bf\u75b1\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u808c\u30c8\u30e9\u30d6\u30eb\u3068\u3057\u3066\u73fe\u308c\u307e\u3059\u3002\u76ae\u8102\u817a\u304c\u6d3b\u767a\u306a\u9854\u30fb\u9996\u30fb\u80f8\u30fb\u80cc\u4e2d\u306b\u3067\u304d\u3084\u3059\u304f\u3001\u601d\u6625\u671f\u306e\u30db\u30eb\u30e2\u30f3\u5909\u5316\u3068\u3068\u3082\u306b\u59cb\u307e\u308b\u306e\u304c\u4e00\u822c\u7684\u3067\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3021992_s.jpg\" alt=\"\u53cc\u5b50\u7814\u7a76\u3067\u30cb\u30ad\u30d3\u306e\u907a\u4f1d\u7387\u3092\u8abf\u3079\u308b\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-12276\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3021992_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3021992_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<p>\u53cc\u5b50\u7814\u7a76\u3067\u306f\u3001\u3056\u7621\u306e\u767a\u75c7\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u7684\u306a\u5bc4\u4e0e\u7387\uff08\u907a\u4f1d\u7387\uff09\u306f\u7d0480\uff05\u3068\u4e00\u8cab\u3057\u3066\u9ad8\u304f\u3001\u660e\u78ba\u306a\u907a\u4f1d\u7684\u80cc\u666f\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u5375\u6027\u53cc\u751f\u5150\u306f\u907a\u4f1d\u5b50\u304c\u307b\u307c\u540c\u3058\u305f\u3081\u3001\u4e8c\u5375\u6027\u53cc\u751f\u5150\u3068\u6bd4\u3079\u3066\u30cb\u30ad\u30d3\u306e\u4e00\u81f4\u7387\u304c\u9ad8\u3044\u307b\u3069\u300c\u907a\u4f1d\u306e\u5f71\u97ff\u304c\u5927\u304d\u3044\u300d\u3068\u5224\u65ad\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u79c1\u81ea\u8eab\u3001\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3067\u300c\u601d\u6625\u671f\u306e\u9803\u3001\u6bcd\u3082\u540c\u3058\u5834\u6240\u306b\u30cb\u30ad\u30d3\u304c\u3067\u304d\u3066\u3044\u305f\u300d\u3068\u3044\u3046\u8a71\u3092\u4f55\u5ea6\u3082\u805e\u3044\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u300c\u5bb6\u65cf\u3067\u4f3c\u308b\u300d\u3068\u3044\u3046\u5b9f\u611f\u306f\u3001\u6c7a\u3057\u3066\u6c17\u306e\u305b\u3044\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5b9f\u969b\u3001\u5316\u7ca7\u54c1\u7814\u7a76\u8005\u306e<a href=\"https:\/\/x.com\/natsunatsu_7722\" target=\"_blank\" rel=\"noopener\">@natsunatsu_7722<\/a>\u3055\u3093\u3082\u3001\u7d041,500\u7d44\u306e\u53cc\u5b50\u3092\u5bfe\u8c61\u306b\u3057\u305f\u7814\u7a76\u3092\u5f15\u7528\u3057\u300c\u30cb\u30ad\u30d3\u306e\u539f\u56e0\u306e\u591a\u304f\u306f\u907a\u4f1d\u306b\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u300d\u3068\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u751f\u6d3b\u7fd2\u6163\u3060\u3051\u304c\u539f\u56e0\u3067\u306f\u306a\u3044\u3001\u3068\u3044\u3046\u306e\u306f\u5c02\u9580\u5bb6\u306e\u9593\u3067\u3082\u5171\u6709\u3055\u308c\u305f\u898b\u65b9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30cb\u30ad\u30d3\u306f\u4e16\u754c\u3067\u6700\u3082\u591a\u3044\u76ae\u819a\u75be\u60a3\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u601d\u6625\u671f\u306e\u7d0485\uff05\u304c\u4f55\u3089\u304b\u306e\u3056\u7621\u3092\u7d4c\u9a13\u3057\u3001\u305d\u306e\u3046\u3061\u7d048\uff05\u304c\u91cd\u75c7\u578b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u91cd\u75c7\u306e\u30cb\u30ad\u30d3\u306f\u7622\u75d5\uff08\u30cb\u30ad\u30d3\u8de1\uff09\u3092\u6b8b\u3057\u3084\u3059\u304f\u3001\u6c17\u5206\u306e\u843d\u3061\u8fbc\u307f\u3084\u4e0d\u5b89\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3060\u304b\u3089\u3053\u305d\u300c\u4f53\u8cea\u3060\u304b\u3089\u300d\u3068\u3042\u304d\u3089\u3081\u305a\u3001\u65e9\u3081\u306b\u5411\u304d\u5408\u3046\u4fa1\u5024\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u30cb\u30ad\u30d3\u30fb\u808c\u8352\u308c\u306b\u95a2\u308f\u308b\u8981\u56e0\u3068\u5bfe\u7b56\u306e\u65e9\u898b\u8868<\/h2>\n\n\n\n<p><strong>\u30cb\u30ad\u30d3\u30fb\u808c\u8352\u308c\u306f\u300c\u76ae\u8102\u30fb\u6bdb\u5305\u306e\u69cb\u9020\u30fb\u76ae\u819a\u30d0\u30ea\u30a2\u30fb\u708e\u75c7\u30fb\u30db\u30eb\u30e2\u30f3\u300d\u3068\u3044\u3046\u8907\u6570\u306e\u8981\u56e0\u304c\u91cd\u306a\u3063\u3066\u8d77\u3053\u308a\u3001\u305d\u308c\u305e\u308c\u306b\u5bfe\u7b56\u304c\u3042\u308a\u307e\u3059\u3002<\/strong>\u81ea\u5206\u304c\u3069\u306e\u30bf\u30a4\u30d7\u306b\u8fd1\u3044\u304b\u3092\u77e5\u308b\u3068\u3001\u30b1\u30a2\u306e\u512a\u5148\u9806\u4f4d\u304c\u898b\u3048\u3066\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>\u95a2\u308f\u308b\u8981\u56e0<\/th><th>\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u30fb\u4ed5\u7d44\u307f<\/th><th>\u4f53\u8cea\u306e\u50be\u5411<\/th><th>\u4eca\u65e5\u304b\u3089\u3067\u304d\u308b\u5bfe\u7b56<\/th><\/tr><\/thead><tbody><tr><td>\u76ae\u8102\u306e\u5206\u6ccc\u91cf<\/td><td>\u30db\u30eb\u30e2\u30f3\u5fdc\u7b54\u30fb\u6bdb\u5305\u76ae\u8102\u817a\u30e6\u30cb\u30c3\u30c8<\/td><td>\u76ae\u8102\u304c\u591a\u304f\u30c6\u30ab\u308a\u3084\u3059\u3044<\/td><td>\u6d17\u3044\u3059\u304e\u3092\u907f\u3051\u3001\u4f4e\u523a\u6fc0\u306e\u6d17\u9854\u306b\u3059\u308b<\/td><\/tr><tr><td>\u6bdb\u5305\uff08\u6bdb\u7a74\uff09\u306e\u69cb\u9020<\/td><td>EDAR\u30fbWNT10A<\/td><td>\u6bdb\u7a74\u304c\u8a70\u307e\u308a\u3084\u3059\u3044<\/td><td>\u89d2\u8cea\u30b1\u30a2\u3068\u30ce\u30f3\u30b3\u30e1\u30c9\u30b8\u30a7\u30cb\u30c3\u30af\u88fd\u54c1<\/td><\/tr><tr><td>\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd<\/td><td>TGFB2\u30fbCSTA<\/td><td>\u4e7e\u71e5\u30fb\u808c\u8352\u308c\u3057\u3084\u3059\u3044<\/td><td>\u4fdd\u6e7f\u3092\u5fb9\u5e95\u3057\u3001\u6469\u64e6\u3092\u907f\u3051\u308b<\/td><\/tr><tr><td>\u708e\u75c7\u306e\u8d77\u3053\u3057\u3084\u3059\u3055<\/td><td>IL36RN\u306a\u3069\u514d\u75ab\u95a2\u9023\u907a\u4f1d\u5b50<\/td><td>\u8d64\u307f\u3084\u708e\u75c7\u304c\u9577\u5f15\u304f<\/td><td>\u60aa\u5316\u3059\u308b\u524d\u306b\u76ae\u819a\u79d1\u3092\u53d7\u8a3a\u3059\u308b<\/td><\/tr><tr><td>\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9<\/td><td>\u30db\u30eb\u30e2\u30f3\u5fdc\u7b54\u7cfb<\/td><td>\u751f\u7406\u524d\u3084\u601d\u6625\u671f\u306b\u60aa\u5316<\/td><td>\u7761\u7720\u30fb\u98df\u4e8b\u30fb\u30b9\u30c8\u30ec\u30b9\u3092\u6574\u3048\u308b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>\u808c\u8cea\u305d\u306e\u3082\u306e\u306e\u30bf\u30a4\u30d7\u5206\u3051\u306b\u3064\u3044\u3066\u306f\u3001\u59c9\u59b9\u8a18\u4e8b\u306e<a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%ae%e7%a0%94%e7%a9%b6%e3%81%8c%e6%98%8e%e3%81%8b%e3%81%99%e8%82%8c%e8%b3%aa%e3%81%ae%e9%81%95%e3%81%84\/\" target=\"_blank\" rel=\"noopener\">\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u304c\u660e\u304b\u3059\u808c\u8cea\u306e\u9055\u3044<\/a>\u3067\u3082\u8a73\u3057\u304f\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002\u3042\u308f\u305b\u3066\u8aad\u3080\u3068\u3001\u81ea\u5206\u306e\u808c\u30bf\u30a4\u30d7\u3078\u306e\u7406\u89e3\u304c\u6df1\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30cb\u30ad\u30d3\u30fb\u808c\u8352\u308c\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3068SNP<\/h2>\n\n\n\n<p><strong>\u6700\u65b0\u306e\u89e3\u6790\u3067\u306f\u3001\u30cb\u30ad\u30d3\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u5ea7\u306f43\u30ab\u6240\u30fb46\u500b\u306eSNP\u304c\u7279\u5b9a\u3055\u308c\u3001\u76ae\u819a\u306e\u69cb\u9020\u3068\u514d\u75ab\u306e\u4e21\u65b9\u304c\u4f53\u8cea\u3092\u5de6\u53f3\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/strong>\u3053\u3053\u3067\u306f\u4ee3\u8868\u7684\u306a\u907a\u4f1d\u5b50\u3092\u3001\u306f\u305f\u3089\u304d\u3068\u3042\u308f\u305b\u3066\u898b\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>SNP\uff08Single Nucleotide Polymorphism\uff1a\u4e00\u5869\u57fa\u591a\u578b\uff09\u3068\u306f\u3001\u907a\u4f1d\u5b50\u306e\u305f\u3063\u305f1\u6587\u5b57\u306e\u500b\u4eba\u5dee\u306e\u3053\u3068\u3002\u3053\u306e\u5c0f\u3055\u306a\u9055\u3044\u304c\u3001\u30cb\u30ad\u30d3\u306e\u3067\u304d\u3084\u3059\u3055\u306b\u5f71\u97ff\u3057\u307e\u3059\u30022022\u5e74\u306e\u5927\u898f\u6a21\u7814\u7a76\u3067\u306f\u300143\u306e\u907a\u4f1d\u5b50\u5ea7\u306746\u306eSNP\u304c\u3056\u7621\u3068\u95a2\u9023\u3057\u3001\u305d\u306e\u3046\u306129\u30ab\u6240\u306f\u4e16\u754c\u3067\u521d\u3081\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00-1024x25.png\" alt=\"\u30cb\u30ad\u30d3\u95a2\u9023SNP rs1256580\u306e\u67d3\u8272\u4f53\u4e0a\u306e\u4f4d\u7f6e\" class=\"wp-image-12651\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1256580-hgtIdeo_genome_388b0e_fa0d00.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>rs1256580\uff08TGFB2\u907a\u4f1d\u5b50\u30011q41\uff09<\/strong>\uff1a\u539f\u56e0\u5019\u88dc\u3067\u3042\u308b\u78ba\u7387\uff08\u5f8c\u65b9\u78ba\u7387\uff09\u304c0.9962\u3068\u975e\u5e38\u306b\u9ad8\u3044SNP\u3067\u3059\u3002TGFB2\u306f\u4e0a\u76ae\u7d44\u7e54\u306e\u6210\u9577\u3084\u5206\u5316\u3092\u5236\u5fa1\u3057\u3001\u76ae\u819a\u30d0\u30ea\u30a2\u306e\u5f62\u6210\u3084\u50b7\u306e\u6cbb\u308a\u306b\u95a2\u308f\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>rs260643\uff08EDAR\u907a\u4f1d\u5b50\u30012q12.3\uff09<\/strong>\uff1aEDAR\u306f\u6bdb\u9aea\u30fb\u6c57\u817a\u30fb\u6b6f\u306a\u3069\u3001\u76ae\u819a\u307e\u308f\u308a\u306e\u7d44\u7e54\u3065\u304f\u308a\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3059\u3002\u9aea\u306e\u30ab\u30fc\u30eb\u3068\u3082\u95a2\u9023\u3057\u30011\u3064\u306e\u907a\u4f1d\u5b50\u304c\u8907\u6570\u306e\u898b\u305f\u76ee\u306b\u5f71\u97ff\u3059\u308b\u300c\u591a\u9762\u7684\u8868\u73fe\u578b\u300d\u3092\u793a\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>rs74333950\uff08WNT10A\u907a\u4f1d\u5b50\u30012q35\uff09<\/strong>\uff1a\u6bdb\u5305\u306e\u767a\u751f\u3084\u76ae\u8102\u817a\u306e\u6a5f\u80fd\u8abf\u6574\u306b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3001\u9aea\u8cea\u3084\u8131\u6bdb\u75c7\u3068\u306e\u95a2\u9023\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>rs6842241\uff08EDNRA\u907a\u4f1d\u5b50\u8fd1\u508d\u30014q31.22\uff09<\/strong>\uff1a\u30ea\u30b9\u30af\u3068\u306a\u308b\u578b\u306fEDNRA\uff08\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3\u53d7\u5bb9\u4f53A\u578b\uff09\u306e\u306f\u305f\u3089\u304d\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3001\u5f8c\u65b9\u78ba\u7387\u306f0.98\u3067\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>rs17265703\uff08CSTA\u907a\u4f1d\u5b50\u30013q21.1\uff09<\/strong>\uff1aCSTA\u306f\u76ae\u819a\u7d30\u80de\u3069\u3046\u3057\u306e\u63a5\u7740\u3092\u4fdd\u3064\u56e0\u5b50\u3067\u3059\u3002\u306f\u305f\u3089\u304d\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u89d2\u5316\u7570\u5e38\u3084\u76ae\u819a\u306e\u306f\u304c\u308c\u3092\u8d77\u3053\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>rs6735739\uff08IL36RN\u907a\u4f1d\u5b50\u8fd1\u508d\u30012q13\uff09<\/strong>\uff1aIL36RN\u306f\u708e\u75c7\u3092\u6291\u3048\u308b\u56e0\u5b50\u3067\u3001\u306f\u305f\u3089\u304d\u306e\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u76ae\u819a\u306e\u708e\u75c7\u306e\u3057\u3084\u3059\u3055\u306b\u95a2\u308f\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u307b\u304b\u3001\u7d30\u80de\u63a5\u7740\u30fb\u514d\u75ab\u30fb\u4e0a\u76ae\u306e\u5206\u5316\u306b\u95a2\u308f\u308b\u591a\u304f\u306e\u907a\u4f1d\u5b50\uff08LAMC2\u3001LGR6\u3001GLI2\u3001PRDM1\u3001FGF10\u306a\u3069\uff09\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u30cb\u30ad\u30d3\u304c\u300c\u76ae\u819a\u306e\u69cb\u9020\u300d\u3068\u300c\u514d\u75ab\u300d\u306e\u4e21\u9762\u304b\u3089\u751f\u307e\u308c\u308b\u4f53\u8cea\u3067\u3042\u308b\u3053\u3068\u304c\u3046\u304b\u304c\u3048\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"488\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1-1024x488.png\" alt=\"EDAR\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7acb\u4f53\u69cb\u9020\u30e2\u30c7\u30eb\" class=\"wp-image-12707\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1-1024x488.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1-300x143.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1-768x366.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9UNE0-F1.png 1046w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u907a\u4f1d\u3060\u3051\u3067\u6c7a\u307e\u3089\u306a\u3044\uff5c\u751f\u6d3b\u7fd2\u6163\u3068\u76ae\u819a\u79d1\u30b1\u30a2\u3067\u808c\u306f\u5909\u3048\u3089\u308c\u308b<\/h2>\n\n\n\n<p><strong>\u907a\u4f1d\u7387\u304c\u9ad8\u304f\u3066\u3082\u3001\u5b9f\u969b\u306b\u30cb\u30ad\u30d3\u304c\u51fa\u308b\u304b\u3069\u3046\u304b\u306f\u751f\u6d3b\u7fd2\u6163\u3068\u9069\u5207\u306a\u30b1\u30a2\u3067\u5927\u304d\u304f\u5909\u308f\u308a\u307e\u3059\u3002<\/strong>\u907a\u4f1d\u306f\u300c\u8d77\u3053\u308a\u3084\u3059\u3055\u300d\u3067\u3042\u3063\u3066\u300c\u5fc5\u305a\u8d77\u3053\u308b\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u6700\u65b0\u7814\u7a76\u3067\u3082\u3001\u6709\u610f\u306aSNP\u3067\u8aac\u660e\u3067\u304d\u308b\u30cb\u30ad\u30d3\u306e\u5272\u5408\u306f6\uff05\u7a0b\u5ea6\u3001SNP\u5168\u4f53\u3092\u5408\u308f\u305b\u305f\u907a\u4f1d\u7387\u3082\u7d0423\uff05\u306b\u3068\u3069\u307e\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u6b8b\u308a\u306e\u5927\u90e8\u5206\u306f\u76ae\u8102\u30fb\u30db\u30eb\u30e2\u30f3\u30fb\u7761\u7720\u30fb\u98df\u4e8b\u30fb\u30b9\u30ad\u30f3\u30b1\u30a2\u3068\u3044\u3063\u305f\u3001\u5f8c\u304b\u3089\u6574\u3048\u3089\u308c\u308b\u8981\u7d20\u304c\u5360\u3081\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u79c1\u81ea\u8eab\u3001\u808c\u306e\u898b\u305f\u76ee\u3092\u5de6\u53f3\u3059\u308b\u306e\u306f\u300c\u907a\u4f1d\u3088\u308a\u3001\u751f\u307e\u308c\u305f\u5f8c\u306b\u3069\u308c\u3060\u3051\u6574\u3048\u308b\u304b\u300d\u3060\u3068\u611f\u3058\u3066\u3044\u307e\u3059\u3002\u7f8e\u5bb9\u306b\u304f\u308f\u3057\u3044<a href=\"https:\/\/x.com\/sora_onenight\" target=\"_blank\" rel=\"noopener\">@sora_onenight<\/a>\u3055\u3093\u3082\u3001\u808c\u8352\u308c\u3084\u30cb\u30ad\u30d3\u306f\u76ae\u819a\u79d1\u3067\u306e\u6cbb\u7642\u3067\u6539\u5584\u3067\u304d\u3001\u907a\u4f1d\u306e\u5f53\u305f\u308a\u5916\u308c\u3088\u308a\u5f8c\u5929\u7684\u306b\u3069\u3053\u307e\u3067\u8a70\u3081\u3089\u308c\u308b\u304b\u306e\u65b9\u304c\u5927\u304d\u3044\u3068\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8003\u3048\u65b9\u306b\u306f\u5f37\u304f\u5171\u611f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u65e5\u304b\u3089\u610f\u8b58\u3057\u305f\u3044\u30dd\u30a4\u30f3\u30c8\u3092\u6319\u3052\u307e\u3059\u3002\u307e\u305a\u306f\u7761\u7720\u3068\u98df\u4e8b\u306e\u30ea\u30ba\u30e0\u3092\u6574\u3048\u3001\u76ae\u8102\u3084\u708e\u75c7\u306e\u60aa\u5316\u8981\u56e0\u3092\u6e1b\u3089\u3059\u3053\u3068\u3002\u6b21\u306b\u3001\u6d17\u3044\u3059\u304e\u305a\u4fdd\u6e7f\u3092\u4fdd\u3064\u3053\u3068\u3002\u4e7e\u71e5\u306f\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5f31\u3081\u3001\u304b\u3048\u3063\u3066\u808c\u8352\u308c\u3092\u62db\u304d\u307e\u3059\u3002\u305d\u3057\u3066\u708e\u75c7\u3084\u81bf\u3092\u3082\u3063\u305f\u30cb\u30ad\u30d3\u304c\u7d9a\u304f\u3068\u304d\u306f\u3001\u5e02\u8ca9\u54c1\u3067\u7c98\u3089\u305a\u76ae\u819a\u79d1\u3092\u53d7\u8a3a\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u30cb\u30ad\u30d3\u8de1\u306b\u306a\u308b\u524d\u306e\u53d7\u8a3a\u304c\u3001\u5c06\u6765\u306e\u808c\u3092\u5b88\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u654f\u611f\u3067\u8352\u308c\u3084\u3059\u3044\u808c\u306e\u30b1\u30a2\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%8c%e6%95%99%e3%81%88%e3%82%8b%e8%82%8c%e3%81%ae%e6%95%8f%e6%84%9f%e3%81%95%e3%81%a8%e9%81%a9%e5%88%87%e3%81%aa%e3%82%b1%e3%82%a2\/\" target=\"_blank\" rel=\"noopener\">\u907a\u4f1d\u5b50\u304c\u6559\u3048\u308b\u808c\u306e\u654f\u611f\u3055\u3068\u9069\u5207\u306a\u30b1\u30a2<\/a>\u3001\u81ea\u5206\u306e\u808c\u8cea\u306b\u5408\u3046\u624b\u9806\u9078\u3073\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/column-gene-skin-relationship-care-hiroclinic\/\" target=\"_blank\" rel=\"noopener\">\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u308f\u304b\u308b\u808c\u8cea\u3068\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u9078\u3073\u65b9<\/a>\u3067\u5177\u4f53\u7684\u306b\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31473475_s.jpg\" alt=\"\u808c\u30c8\u30e9\u30d6\u30eb\u304c\u843d\u3061\u7740\u3044\u3066\u7b11\u9854\u306e\u5973\u6027\" class=\"wp-image-12721\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31473475_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31473475_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/\">\u81ea\u5206\u306e\u808c\u30fb\u4f53\u8cea\u306e\u907a\u4f1d\u30ea\u30b9\u30af\u3092\u30c1\u30a7\u30c3\u30af\u3057\u3066\u307f\u308b<\/a><\/div>\n<\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u6700\u65b0\u7814\u7a76\u304b\u3089\u308f\u304b\u3063\u305f\u3053\u3068\uff5c\u8003\u5bdf<\/h2>\n\n\n\n<p><strong>\u3053\u306e\u7814\u7a76\u306f\u3001\u30cb\u30ad\u30d3\u95a2\u9023\u306e\u907a\u4f1d\u5b50\u5ea7\u3092\u5f93\u6765\u306e\u7d044\u500d\u306b\u5e83\u3052\u3001\u76ae\u819a\u306e\u69cb\u9020\u3068\u5168\u8eab\u306e\u708e\u75c7\u306e\u4e21\u65b9\u304c\u4f53\u8cea\u306b\u95a2\u308f\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/strong><\/p>\n\n\n\n<p>\u7279\u306bEDAR\u3084WNT10A\u3068\u3044\u3063\u305f\u6bdb\u5305\u306e\u69cb\u9020\u3068\u5206\u5316\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u5ea7\u304c\u5f37\u304f\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u76ae\u819a\u3084\u76ae\u8102\u817a\u306e\u5f62\u3065\u304f\u308a\u304c\u30cb\u30ad\u30d3\u767a\u75c7\u306b\u6df1\u304f\u95a2\u308f\u308b\u3053\u3068\u3092\u88cf\u3065\u3051\u307e\u3057\u305f\u3002\u307e\u305fIL36RN\u306a\u3069\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\u306f\u3001\u81bf\u75b1\u6027\u4e7e\u766c\u306a\u3069\u306e\u81ea\u5df1\u708e\u75c7\u6027\u76ae\u819a\u75be\u60a3\u3068\u5171\u901a\u3059\u308b\u7d4c\u8def\u3092\u793a\u3057\u3001\u30cb\u30ad\u30d3\u304c\u708e\u75c7\u6027\u75be\u60a3\u306e\u5ef6\u9577\u7dda\u4e0a\u306b\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u30cb\u30ad\u30d3\u306f\u4ee5\u4e0b\u306e\u75be\u60a3\u30fb\u4f53\u8cea\u3068\u3086\u308b\u3084\u304b\u306a\u907a\u4f1d\u7684\u76f8\u95a2\uff08rg\uff09\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u30cb\u30ad\u30d3\u304c\u5358\u306a\u308b\u76ae\u819a\u306e\u554f\u984c\u3067\u306f\u306a\u304f\u3001\u5168\u8eab\u306e\u751f\u7269\u5b66\u7684\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3068\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30af\u30ed\u30fc\u30f3\u75c5\uff1a\u76f8\u95a2\u4fc2\u6570 rg = 0.19<\/li>\n\n\n\n<li>\u7d71\u5408\u5931\u8abf\u75c7\uff1arg = 0.18<\/li>\n\n\n\n<li>\u4e73\u304c\u3093\uff1arg = 0.16<\/li>\n\n\n\n<li>\u53cc\u6975\u6027\u969c\u5bb3\uff1arg = 0.12<\/li>\n\n\n\n<li>\u6162\u6027\u75bc\u75db\uff08\u982d\u75db\u30fb\u95a2\u7bc0\u75db\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u306a\u304a\u3001\u4e2d\u56fd\u30fb\u6f22\u6c11\u65cf\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u305f2\u3064\u306eSNP\u306f\u4eca\u56de\u518d\u73fe\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u4eba\u7a2e\u306b\u3088\u308b\u907a\u4f1d\u7684\u80cc\u666f\u306e\u9055\u3044\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u65e5\u672c\u3092\u542b\u3080\u975e\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u96c6\u56e3\u3067\u306e\u7814\u7a76\u304c\u3053\u308c\u304b\u3089\u5fc5\u8981\u3060\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3458586_s.jpg\" alt=\"\u4eba\u7a2e\u306b\u3088\u308b\u907a\u4f1d\u7684\u80cc\u666f\u306e\u9055\u3044\u3092\u8868\u3059\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-12389\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3458586_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3458586_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<p><strong>\u672c\u7814\u7a76\u306f\u3001\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u96c6\u56e361\u4e07\u4eba\u8d85\u3092\u5bfe\u8c61\u306b\u3057\u305f14\u306eGWAS\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u305f\u5927\u898f\u6a21\u30e1\u30bf\u89e3\u6790\u3067\u3059\u3002<\/strong>\u75c7\u4f8b20,165\u4f8b\u3001\u5bfe\u7167595,231\u4f8b\u3001\u5408\u8a08615,396\u4eba\u304c\u89e3\u6790\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30bf\u89e3\u6790\uff1a\u9006\u5206\u6563\u52a0\u91cd\u6cd5\u3067\u89e3\u6790\u3057\u3001\u983b\u5ea6\u306e\u4f4e\u3044SNP\u3084\u7cbe\u5ea6\u306e\u4f4e\u3044SNP\u3092\u9664\u3044\u305f\u7d04707\u4e07SNP\u3092\u5bfe\u8c61\u306b\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u30d5\u30a1\u30a4\u30f3\u30de\u30c3\u30d4\u30f3\u30b0\uff1a\u5404\u907a\u4f1d\u5b50\u5ea7\u3067\u539f\u56e0\u5019\u88dc\u306eSNP\u3092\u7d5e\u308a\u8fbc\u307f\u3001\u771f\u306e\u539f\u56e0\u309295\uff05\u306e\u78ba\u7387\u3067\u542b\u3080\u300c\u30af\u30ec\u30c7\u30a3\u30d6\u30eb\u30bb\u30c3\u30c8\u300d\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u5171\u5c40\u5728\u89e3\u6790\uff1a\u76ae\u819a\u7d44\u7e54\u3067\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u30c7\u30fc\u30bf\uff08eQTL\uff09\u3092\u4f7f\u3044\u3001GWAS\u306e\u4fe1\u53f7\u3068\u767a\u73fe\u306e\u4fe1\u53f7\u304c\u91cd\u306a\u308b\u304b\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u7387\u3068\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\uff1aSNP\u3092\u3082\u3068\u306b\u3057\u305f\u907a\u4f1d\u7387\u3092\u63a8\u5b9a\u3057\u3001\u5225\u306e\u96c6\u56e3\u3067\u30cb\u30ad\u30d3\u306e\u4e88\u6e2c\u529b\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<p><strong>\u5168\u4f53\u306743\u5ea7\u30fb46\u500b\u306eSNP\u304c\u30cb\u30ad\u30d3\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3001\u3046\u306129\u5ea7\u306f\u65b0\u898f\u767a\u898b\u3067\u3057\u305f\u3002<\/strong>\u91cd\u75c7\u4f8b\u307b\u3069\u907a\u4f1d\u7684\u306a\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>GWAS\u7d50\u679c\uff1a43\u5ea7\u30fb46\u500b\u306e\u72ec\u7acbSNP\u304c\u6709\u610f\u306b\u95a2\u9023\uff08P &lt; 5\u00d710\u207b\u2078\uff09\u3002\u3046\u306129\u5ea7\u306f\u65b0\u898f\u306b\u540c\u5b9a\u3002<\/li>\n\n\n\n<li>\u518d\u73fe\u6027\uff1a\u65e2\u583117\u5ea7\u306e\u3046\u306114\u5ea7\u3067\u518d\u73fe\u3002\u6f22\u6c11\u65cf\u7531\u6765\u306e2\u5ea7\u306f\u518d\u73fe\u3055\u308c\u305a\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u7387\uff1a\u6709\u610fSNP\u3067\u8aac\u660e\u3067\u304d\u308b\u5272\u5408\u306f6.01\uff05\u3001SNP\u5168\u4f53\u306e\u907a\u4f1d\u7387\u306f22.95\uff05\u3002<\/li>\n\n\n\n<li>\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\uff1a\u4e2d\u7b49\u5ea6\u301c\u91cd\u75c7\u306e\u30cb\u30ad\u30d3\u7fa4\u306f\u7121\u75c7\u72b6\u7fa4\u3088\u308a\u5e73\u5747\u30b9\u30b3\u30a2\u304c\u6709\u610f\u306b\u9ad8\u304f\u3001\u91cd\u75c7\u4f8b\u3067\u306e\u4e88\u6e2c\u7cbe\u5ea6\uff08AUC\uff09\u306f0.719\u306b\u9054\u3057\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"416\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32186194_s.jpg\" alt=\"\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u7d50\u679c\u3092\u5206\u6790\u3059\u308b\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-12728\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32186194_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32186194_s-300x195.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u307e\u3068\u3081\uff5c\u907a\u4f1d\u3092\u77e5\u308a\u3001\u4eca\u65e5\u304b\u3089\u3067\u304d\u308b\u808c\u8352\u308c\u5bfe\u7b56\u3078<\/h2>\n\n\n\n<p>\u30cb\u30ad\u30d3\u30fb\u808c\u8352\u308c\u4f53\u8cea\u306b\u306f\u7d0480\uff05\u3068\u3044\u3046\u9ad8\u3044\u907a\u4f1d\u7684\u80cc\u666f\u304c\u3042\u308a\u3001\u6700\u65b0\u7814\u7a76\u3067\u306f46\u3082\u306e\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u304c\u7279\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u6bdb\u5305\u306e\u69cb\u9020\u30fb\u76ae\u819a\u30d0\u30ea\u30a2\u30fb\u514d\u75ab\u30fb\u30db\u30eb\u30e2\u30f3\u306a\u3069\u3001\u8907\u6570\u306e\u4ed5\u7d44\u307f\u304c\u91cd\u306a\u3063\u3066\u4f53\u8cea\u3092\u3064\u304f\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u308c\u3067\u3082\u3001\u907a\u4f1d\u306f\u3042\u304f\u307e\u3067\u300c\u306a\u308a\u3084\u3059\u3055\u300d\u3002\u751f\u6d3b\u7fd2\u6163\u3092\u6574\u3048\u3001\u808c\u306b\u5408\u3063\u305f\u30b1\u30a2\u3092\u7d9a\u3051\u3001\u5fc5\u8981\u306a\u3068\u304d\u306b\u76ae\u819a\u79d1\u3092\u983c\u308c\u3070\u3001\u808c\u306e\u72b6\u614b\u306f\u7740\u5b9f\u306b\u5909\u3048\u3089\u308c\u307e\u3059\u3002\u300c\u5bb6\u65cf\u307f\u3093\u306a\u808c\u304c\u5f31\u3044\u304b\u3089\u300d\u3068\u3042\u304d\u3089\u3081\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u81ea\u5206\u306e\u4f53\u8cea\u3092\u77e5\u308b\u3053\u3068\u3053\u305d\u3001\u5bfe\u7b56\u306e\u7b2c\u4e00\u6b69\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u808c\u306e\u8272\u3068\u907a\u4f1d\u306e\u95a2\u4fc2\u3092\u77e5\u308a\u305f\u3044\u65b9\u306f<a href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e8%82%8c%e3%81%ae%e3%83%88%e3%83%bc%e3%83%b3%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e5%9b%a0%e3%81%8c%e4%b8%8e%e3%81%88%e3%82%8b%e5%bd%b1%e9%9f%bf\/\" target=\"_blank\" rel=\"noopener\">\u808c\u306e\u8272\u306f\u907a\u4f1d\u3067\u6c7a\u307e\u308b\uff1f\u30e1\u30e9\u30cb\u30f3\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/a>\u3082\u3042\u308f\u305b\u3066\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link has-vivid-red-background-color has-background wp-element-button\" href=\"https:\/\/www.hiro-clinic.or.jp\/gene\/\">\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u81ea\u5206\u306e\u808c\u30fb\u4f53\u8cea\u306e\u30ea\u30b9\u30af\u3092\u77e5\u308b\uff08\u30d2\u30ed\u30af\u30ea\u30cb\u30c3\u30af\u306e\u907a\u4f1d\u5b50\u691c\u67fb\uff09<\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u3088\u304f\u3042\u308b\u8cea\u554f\uff08FAQ\uff09<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u30cb\u30ad\u30d3\u306f\u907a\u4f1d\u3057\u307e\u3059\u304b\uff1f<\/h3>\n\n\n\n<p>\u306f\u3044\u3001\u30cb\u30ad\u30d3\u306e\u306a\u308a\u3084\u3059\u3055\u306b\u306f\u5f37\u3044\u907a\u4f1d\u7684\u80cc\u666f\u304c\u3042\u308a\u307e\u3059\u3002\u53cc\u5b50\u7814\u7a76\u3067\u306f\u907a\u4f1d\u7387\u304c\u7d0480\uff05\u3068\u5831\u544a\u3055\u308c\u30012022\u5e74\u306e\u5927\u898f\u6a21\u89e3\u6790\u3067\u306f46\u306e\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u304c\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u907a\u4f1d\u306f\u300c\u306a\u308a\u3084\u3059\u3055\u300d\u3092\u793a\u3059\u3082\u306e\u3067\u3001\u5fc5\u305a\u767a\u75c7\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u89aa\u304c\u30cb\u30ad\u30d3\u808c\u3060\u3068\u3001\u5b50\u3069\u3082\u3082\u5fc5\u305a\u30cb\u30ad\u30d3\u306b\u306a\u308a\u307e\u3059\u304b\uff1f<\/h3>\n\n\n\n<p>\u5fc5\u305a\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u907a\u4f1d\u738780\uff05\u306f\u300c\u96c6\u56e3\u5168\u4f53\u3067\u898b\u305f\u3068\u304d\u306e\u907a\u4f1d\u306e\u5bc4\u4e0e\u5ea6\u300d\u3067\u3042\u308a\u3001\u500b\u4eba\u304c\u5fc5\u305a\u767a\u75c7\u3059\u308b\u78ba\u7387\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5bb6\u65cf\u306b\u591a\u3044\u5834\u5408\u306f\u306a\u308a\u3084\u3059\u3044\u50be\u5411\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u751f\u6d3b\u7fd2\u6163\u3084\u30b9\u30ad\u30f3\u30b1\u30a2\u3067\u5927\u304d\u304f\u5dee\u304c\u3064\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u808c\u8352\u308c\u3057\u3084\u3059\u3044\u4f53\u8cea\u306f\u5909\u3048\u3089\u308c\u307e\u3059\u304b\uff1f<\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u305d\u306e\u3082\u306e\u306f\u5909\u3048\u3089\u308c\u307e\u305b\u3093\u304c\u3001\u808c\u306e\u72b6\u614b\u306f\u5909\u3048\u3089\u308c\u307e\u3059\u3002\u7814\u7a76\u3067\u3082SNP\u5168\u4f53\u3067\u8aac\u660e\u3067\u304d\u308b\u5272\u5408\u306f\u7d0423\uff05\u306b\u3068\u3069\u307e\u308a\u3001\u6b8b\u308a\u306f\u7761\u7720\u30fb\u98df\u4e8b\u30fb\u4fdd\u6e7f\u30fb\u76ae\u819a\u79d1\u6cbb\u7642\u306a\u3069\u5f8c\u304b\u3089\u6574\u3048\u3089\u308c\u308b\u8981\u7d20\u3067\u3059\u3002\u60aa\u5316\u3059\u308b\u524d\u306e\u30b1\u30a2\u304c\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u30cb\u30ad\u30d3\u306e\u306a\u308a\u3084\u3059\u3055\u306f\u308f\u304b\u308a\u307e\u3059\u304b\uff1f<\/h3>\n\n\n\n<p>\u73fe\u6642\u70b9\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u300c\u306a\u308a\u3084\u3059\u3055\u306e\u50be\u5411\u300d\u3092\u77e5\u308b\u53c2\u8003\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u767a\u75c7\u3092\u78ba\u5b9a\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\u306e\u4e88\u6e2c\u7cbe\u5ea6\u306f\u91cd\u75c7\u4f8b\u3067\u9ad8\u3044\u4e00\u65b9\u3001\u4e00\u822c\u7684\u306a\u30cb\u30ad\u30d3\u306e\u4e88\u6e2c\u529b\u306f\u307e\u3060\u9650\u5b9a\u7684\u3067\u3059\u3002\u81ea\u5206\u306e\u4f53\u8cea\u50be\u5411\u3092\u77e5\u308a\u3001\u5bfe\u7b56\u306e\u30d2\u30f3\u30c8\u306b\u3059\u308b\u4f7f\u3044\u65b9\u304c\u73fe\u5b9f\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u30cb\u30ad\u30d3\u304c\u907a\u4f1d\u3067\u3082\u3001\u76ae\u819a\u79d1\u306b\u884c\u304f\u610f\u5473\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/h3>\n\n\n\n<p>\u5927\u3044\u306b\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u7684\u306b\u3067\u304d\u3084\u3059\u304f\u3066\u3082\u3001\u708e\u75c7\u3092\u65e9\u304f\u6291\u3048\u308c\u3070\u30cb\u30ad\u30d3\u8de1\u3092\u9632\u3052\u307e\u3059\u3002\u5e02\u8ca9\u54c1\u3067\u6539\u5584\u3057\u306a\u3044\u3001\u708e\u75c7\u3084\u81bf\u3092\u3082\u3063\u305f\u30cb\u30ad\u30d3\u304c\u7d9a\u304f\u5834\u5408\u306f\u3001\u65e9\u3081\u306b\u76ae\u819a\u79d1\u3092\u53d7\u8a3a\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u4f53\u8cea\u3092\u7406\u89e3\u3057\u305f\u3046\u3048\u3067\u306e\u6cbb\u7642\u304c\u3001\u6700\u3082\u9060\u56de\u308a\u306e\u306a\u3044\u5bfe\u7b56\u3067\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41467-022-28252-5\" target=\"_blank\" rel=\"noopener\">Mitchell, B.L., Saklatvala, J.R., Dand, N. <em>et al.<\/em> Genome-wide association meta-analysis identifies 29 new acne susceptibility loci. <em>Nat Commun<\/em> <strong>13<\/strong>, 702 (2022).<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\" target=\"_blank\" rel=\"noopener\">The UniProt Consortium. UniProt: the Universal Protein Knowledgebase in 2025. <em>Nucleic Acids Research<\/em>, 53(D1), D609\u2013D617 (2025).<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\" target=\"_blank\" rel=\"noopener\">Jumper, J. <em>et al.<\/em> Highly accurate protein structure prediction with AlphaFold. <em>Nature<\/em>, 596(7873), 583\u2013589 (2021).<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\" target=\"_blank\" rel=\"noopener\">Cheng, J. <em>et al.<\/em> Accurate proteome-wide missense variant effect prediction with AlphaMissense. <em>Science<\/em>, 381(6664), eadg7492 (2023).<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<script 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