{"id":12765,"date":"2025-04-07T00:20:52","date_gmt":"2025-04-07T00:20:52","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=12765"},"modified":"2025-04-07T01:14:46","modified_gmt":"2025-04-07T01:14:46","slug":"cad","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/cad\/","title":{"rendered":"\u5fc3\u7b4b\u6897\u585e\u306e\u907a\u4f1d\u30ea\u30b9\u30af\u306f\u9ad8\u9f62\u3067\u3082\u95a2\u4fc2\u3042\u308b\uff1f\u9577\u5bff\u7814\u7a76\u304c\u660e\u304b\u3059\u201c9p21\u907a\u4f1d\u5b50\u201d\u306e\u5f71\u97ff\u3068\u306f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"737\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo9-MfXaIHKSRcGYMAUENcAAAWbM.png\" alt=\"chromo9\" class=\"wp-image-12781\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo9-MfXaIHKSRcGYMAUENcAAAWbM.png 737w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo9-MfXaIHKSRcGYMAUENcAAAWbM-300x204.png 300w\" sizes=\"(max-width: 737px) 100vw, 737px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u51a0\u52d5\u8108\u75be\u60a3\uff08CAD: Coronary Artery Disease\uff09\u306f\u3001\u52d5\u8108\u786c\u5316\u306b\u3088\u3063\u3066\u51a0\u52d5\u8108\u304c\u72ed\u7a84\u307e\u305f\u306f\u9589\u585e\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u7279\u306b\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u4e3b\u8981\u306a\u6b7b\u4ea1\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS: Genome-Wide Association Studies\uff09\u306b\u3088\u308a\u3001CAD\u306e\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3059\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u5909\u7570\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001\u67d3\u8272\u4f539\u756a\u77ed\u8155\u306ep21\u9818\u57df\uff089p21\uff09\u306b\u4f4d\u7f6e\u3059\u308b\u4e00\u5869\u57fa\u591a\u578b\uff08SNP: Single Nucleotide Polymorphism\uff09\u3067\u3042\u308brs1333049\u304a\u3088\u3073rs10757278\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u4eba\u7a2e\u306b\u304a\u3044\u3066CAD\u304a\u3088\u3073\u5fc3\u7b4b\u6897\u585e\uff08MI: Myocardial Infarction\uff09\u3068\u306e\u5f37\u3044\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs1333049-hgtIdeo_genome_315483_fa7fc0-1024x25.png\" alt=\"rs1333049\" class=\"wp-image-12767\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1333049-hgtIdeo_genome_315483_fa7fc0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1333049-hgtIdeo_genome_315483_fa7fc0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1333049-hgtIdeo_genome_315483_fa7fc0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1333049-hgtIdeo_genome_315483_fa7fc0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u306e\u591a\u304f\u306e\u7814\u7a76\u306f\u4e2d\u5e74\u5c64\u3092\u5bfe\u8c61\u3068\u3057\u3066\u304a\u308a\u30019p21\u907a\u4f1d\u5b50\u591a\u578b\u304c\u9ad8\u9f62\u8005\u306e\u9577\u671f\u7684\u306a\u6b7b\u4ea1\u7387\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u52b9\u679c\u306f\u52a0\u9f62\u3068\u3068\u3082\u306b\u5f31\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u4eee\u8aac\u3082\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001CAD\u306e\u8a3a\u65ad\u3092\u53d7\u3051\u3066\u3044\u306a\u304471\u6b73\u4ee5\u4e0a\u306e\u9ad8\u9f62\u8005\u3092\u5bfe\u8c61\u306b\u30019p21\u306ers1333049\u591a\u578b\u304c20\u5e74\u9593\u306e\u5168\u6b7b\u56e0\u304a\u3088\u3073CAD\u7279\u7570\u7684\u6b7b\u4ea1\u7387\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u3042\u308f\u305b\u3066\u3001\u3053\u306eSNP\u60c5\u5831\u3092\u5f93\u6765\u306eCAD\u30ea\u30b9\u30af\u8a55\u4fa1\u30c4\u30fc\u30eb\u3067\u3042\u308b\u30d5\u30e9\u30df\u30f3\u30ac\u30e0\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08FRS: Framingham Risk Score\uff09\u306b\u52a0\u3048\u308b\u3053\u3068\u3067\u3001\u4e88\u6e2c\u7cbe\u5ea6\u304c\u5411\u4e0a\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"744\" height=\"649\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9NXV6-F1.png\" alt=\"CDKN2A-interacting protein\" class=\"wp-image-12789\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9NXV6-F1.png 744w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9NXV6-F1-300x262.png 300w\" sizes=\"(max-width: 744px) 100vw, 744px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u6ce8\u76ee\u3055\u308c\u305f9p21\u9818\u57df\u306f\u3001\u7d30\u80de\u5468\u671f\u306e\u5236\u5fa1\u3084\u8001\u5316\u306b\u95a2\u4e0e\u3059\u308bCDKN2A\u304a\u3088\u3073CDKN2B\u907a\u4f1d\u5b50\u306b\u96a3\u63a5\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306f\u7d30\u80de\u306e\u5897\u6b96\u505c\u6b62\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\uff09\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002rs1333049\u3084rs10757278\u3068\u3044\u3063\u305fSNP\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30fc\u30c9\u9818\u57df\u306b\u306f\u5b58\u5728\u3057\u306a\u3044\u3082\u306e\u306e\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u975e\u30b3\u30fc\u30c9RNA\uff08\u4f8b\uff1aANRIL; <em>antisense non-coding RNA<\/em>\uff09\u3092\u4ecb\u3057\u3066\u3001\u75be\u60a3\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"183\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-1024x183.png\" alt=\"\u907a\u4f1d\u5909\u7570\" class=\"wp-image-12796\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-1024x183.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-300x54.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-768x137.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-1536x274.png 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-2048x365.png 2048w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001.png 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>rs1333049\u3067\u306f\u3001\u30b0\u30a2\u30cb\u30f3\uff08G\uff09\u304c\u30b7\u30c8\u30b7\u30f3\uff08C\uff09\u306b\u7f6e\u304d\u63db\u308f\u308b\u5909\u7570\u304c\u3042\u308a\u3001C\u30a2\u30ec\u30eb\u304c\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u3068\u3055\u308c\u3001CAD\u3084MI\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3065\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u306e\u30ea\u30b9\u30af\u56e0\u5b50\uff08\u8102\u8cea\u7570\u5e38\u75c7\u3084\u9ad8\u8840\u5727\u3001\u55ab\u7159\u306a\u3069\uff09\u3068\u306f\u72ec\u7acb\u3057\u305f\u7d4c\u8def\u3067\u75be\u60a3\u9032\u5c55\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3001\u7279\u306b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u708e\u75c7\u5fdc\u7b54\u3084\u640d\u50b7\u4fee\u5fa9\u80fd\u529b\u306e\u4f4e\u4e0b\u3092\u901a\u3058\u3066\u3001\u52d5\u8108\u786c\u5316\u306e\u4fc3\u9032\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001C\u30a2\u30ec\u30eb\u306f\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3-\u03b3\uff08IFN-\u03b3: Interferon-gamma\uff09\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u306b\u5e72\u6e09\u3057\u3001\u708e\u75c7\u3078\u306e\u5fdc\u7b54\u3084\u8840\u7ba1\u306e\u4fee\u5fa9\u904e\u7a0b\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u51a0\u52d5\u8108\u306b\u7279\u7570\u7684\u306a\u75c5\u5909\u9032\u884c\u306e\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31518068_s.jpg\" alt=\"\u9ad8\u9f62\u8005\" class=\"wp-image-12804\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31518068_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31518068_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u306e\u7d50\u679c\u304b\u3089\u3001rs1333049\u306eC\u30a2\u30ec\u30eb\u306f\u3001CAD\u306e\u8a3a\u65ad\u6b74\u304c\u306a\u304471\u301c80\u6b73\u306e\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u3001\u5168\u6b7b\u56e0\u304a\u3088\u3073CAD\u7279\u7570\u7684\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u30ea\u30b9\u30af\u306f\u3001\u55ab\u7159\u6b74\u3001\u8840\u5727\u3001\u4f53\u683c\u6307\u6570\uff08BMI: Body Mass Index\uff09\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u7cd6\u5c3f\u75c5\u3068\u3044\u3063\u305f\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3068\u306f\u72ec\u7acb\u3057\u3066\u304a\u308a\u3001\u65b0\u305f\u306a\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5b58\u5728\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23711909_s.jpg\" alt=\"\u4f53\u683c\u6307\u6570\" class=\"wp-image-12811\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23711909_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23711909_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001\u3053\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306e\u5f71\u97ff\u306f\u5e74\u9f62\u4f9d\u5b58\u7684\u3067\u3042\u308a\u300171\u301c80\u6b73\u7fa4\u3067\u660e\u77ad\u306b\u8a8d\u3081\u3089\u308c\u305f\u4e00\u65b9\u300180\u6b73\u3092\u8d85\u3048\u308b\u9ad8\u9f62\u8005\u3067\u306f\u52b9\u679c\u304c\u6e1b\u5f31\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u611f\u53d7\u6027\u306e\u9ad8\u3044\u500b\u4f53\u304c\u65e9\u671f\u306b\u6b7b\u4ea1\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u300c\u9078\u629e\u7684\u751f\u5b58\u300d\u3084\u3001\u6975\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u975e\u907a\u4f1d\u7684\u56e0\u5b50\u306e\u76f8\u5bfe\u7684\u306a\u5f71\u97ff\u5897\u5927\u306a\u3069\u304c\u80cc\u666f\u306b\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<p>\u6ce8\u76ee\u3059\u3079\u304d\u70b9\u3068\u3057\u3066\u3001rs1333049\u3068\u8133\u5352\u4e2d\u306b\u3088\u308b\u6b7b\u4ea1\u3068\u306e\u9593\u306b\u306f\u6709\u610f\u306a\u95a2\u9023\u304c\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u4e00\u8cab\u3057\u306a\u3044\u6240\u898b\u304c\u5f97\u3089\u308c\u3066\u3044\u305f\u70b9\u3068\u4e00\u81f4\u3057\u3001\u672cSNP\u304c\u51a0\u52d5\u8108\u7279\u7570\u7684\u306a\u75c5\u614b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32055854_s.jpg\" alt=\"\u3044\u3057\u3083\" class=\"wp-image-12818\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32055854_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32055854_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e00\u65b9\u3001\u3059\u3067\u306bCAD\u306e\u8a3a\u65ad\u3092\u53d7\u3051\u3066\u3044\u305f\u7fa4\u306b\u304a\u3044\u3066\u306f\u3001\u672cSNP\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u521d\u56de\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u4e57\u308a\u8d8a\u3048\u305f\u300c\u5065\u5eb7\u306a\u751f\u5b58\u8005\u300d\u306b\u7279\u6709\u306e\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u306e\u5f71\u97ff\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5bfe\u8c61\u3092\u542b\u3080\u5f93\u6765\u306e\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3067\u306f\u3001\u751f\u5b58\u7387\u3068\u306e\u95a2\u9023\u304c\u904e\u5c0f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31896558_s.jpg\" alt=\"\u81e8\u5e8a\" class=\"wp-image-12825\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31896558_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31896558_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u672c\u7814\u7a76\u3067\u306f\u3001rs1333049\u306e\u907a\u4f1d\u60c5\u5831\u3092FRS\u306b\u52a0\u3048\u308b\u3053\u3068\u3067\u3001CAD\u306b\u3088\u308b10\u5e74\u4ee5\u5185\u306e\u6b7b\u4ea1\u3092\u4e88\u6e2c\u3059\u308b\u7cbe\u5ea6\u304c6\uff05\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5f93\u6765\u4e2d\u7b49\u5ea6\u30ea\u30b9\u30af\u3068\u5224\u5b9a\u3055\u308c\u305f\u9ad8\u9f62\u8005\u306e\u4e00\u90e8\u3092\u9ad8\u30ea\u30b9\u30af\u7fa4\u306b\u518d\u5206\u985e\u3067\u304d\u305f\u3053\u3068\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u81e8\u5e8a\u4e0a\u306e\u610f\u601d\u6c7a\u5b9a\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg\" alt=\"\" class=\"wp-image-11365\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001\u5168\u7c73\u9ad8\u9f62\u8005\u75ab\u5b66\u7814\u7a76\uff08EPESE: Established Populations for Epidemiological Study of the Elderly\uff09\u306e\u30a2\u30a4\u30aa\u30ef\u30fb\u30b5\u30a4\u30c8\u306b\u53c2\u52a0\u3057\u305f\u9ad8\u9f62\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u30021981\u5e74\u306b\u958b\u59cb\u3055\u308c\u305f\u3053\u306e\u30b3\u30db\u30fc\u30c8\u306f\u3001\u5730\u57df\u5728\u4f4f\u306e65\u6b73\u4ee5\u4e0a\u306e\u9ad8\u9f62\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3001\u8001\u5e74\u671f\u306b\u304a\u3051\u308b\u5065\u5eb7\u3068\u75be\u60a3\u306b\u95a2\u3059\u308b\u7e26\u65ad\u7684\u30c7\u30fc\u30bf\u3092\u53ce\u96c6\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u89e3\u6790\u3067\u306f\u30011988\u5e74\u306b\u884c\u308f\u308c\u305f\u7b2c6\u56de\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u8abf\u67fb\u6642\u306b\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u304c\u63a1\u53d6\u3055\u308c\u305f71\u6b73\u4ee5\u4e0a\u306e\u53c2\u52a0\u80051,752\u540d\u306e\u3046\u3061\u3001DNA\u62bd\u51fa\u306b\u6210\u529f\u3057\u305f1,708\u540d\u3092\u6bcd\u96c6\u56e3\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23463921_s.jpg\" alt=\"\u8840\u6db2\" class=\"wp-image-12832\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23463921_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23463921_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306e\u3046\u3061\u3001\u6b7b\u56e0\u60c5\u5831\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f135\u540d\u3068\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u72ed\u5fc3\u75c7\u306e\u8a3a\u65ad\u307e\u305f\u306f\u7591\u3044\u304c\u3042\u3063\u305f478\u540d\u3092\u9664\u5916\u3057\u3001\u6700\u7d42\u7684\u306b1,095\u540d\u304c\u89e3\u6790\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3057\u305f\u3002CAD\u306e\u65e2\u5f80\u3092\u6301\u3064\u53c2\u52a0\u8005\u3092\u9664\u5916\u3059\u308b\u3053\u3068\u3067\u3001\u75be\u60a3\u9032\u884c\u5f8c\u306e\u751f\u5b58\u30d0\u30a4\u30a2\u30b9\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\u306fTaqMan\u6cd5\u3092\u7528\u3044\u305fPCR\uff08\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9023\u9396\u53cd\u5fdc\uff09\u306b\u3088\u308a\u884c\u308f\u308c\u3001rs1333049\u306f\u30cf\u30fc\u30c7\u30a3\u30fb\u30ef\u30a4\u30f3\u30d9\u30eb\u30b0\u5e73\u8861\u306b\u5408\u81f4\u3057\u3066\u3044\u307e\u3057\u305f\u3002GG\u578b\u306f\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u3092\u6301\u305f\u306a\u3044\u7fa4\u3001GC\u578b\u306f\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u3001CC\u578b\u306f\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u30922\u30b3\u30d4\u30fc\u6301\u3064\u7fa4\u3068\u5b9a\u7fa9\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31454630_s-1.jpg\" alt=\"\u511a\u3044\u4eba\u751f\" class=\"wp-image-12839\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31454630_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31454630_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u6b7b\u56e0\u306f\u3001\u6b7b\u4ea1\u8a3a\u65ad\u66f8\u304a\u3088\u3073National Death Index\u304b\u3089\u53d6\u5f97\u3057\u3001\u56fd\u969b\u75be\u75c5\u5206\u985e\u7b2c9\u7248\uff08ICD-9-CM\uff09\u30b3\u30fc\u30c9\u306b\u57fa\u3065\u3044\u3066\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002CAD\u95a2\u9023\u6b7b\u306f\u3001\u30b3\u30fc\u30c9410\u3001413\u3001414\u306b\u8a72\u5f53\u3059\u308b\u3082\u306e\u3068\u5b9a\u7fa9\u3057\u3001\u8133\u5352\u4e2d\u306b\u3088\u308b\u6b7b\u4ea1\u306f\u30b3\u30fc\u30c9430\u301c438\u306b\u57fa\u3065\u3044\u3066\u7279\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u5171\u5909\u91cf\u3068\u3057\u3066\u306f\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u55ab\u7159\u72b6\u6cc1\uff08\u975e\u55ab\u7159\u8005\u3001\u5143\u55ab\u7159\u8005\u3001\u73fe\u55ab\u7159\u8005\uff09\u3001BMI\u3001\u53ce\u7e2e\u671f\u304a\u3088\u3073\u62e1\u5f35\u671f\u8840\u5727\u3001\u8840\u6e05\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08\u305d\u308c\u305e\u308c\u56db\u5206\u4f4d\u306b\u5206\u985e\uff09\u3001\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u306e\u65e2\u5f80\uff08\u3042\u308a\u3001\u7591\u3044\u3001\u306a\u3057\uff09\u3092\u542b\u3081\u307e\u3057\u305f\u3002\u6b20\u640d\u5024\u3084\u5916\u308c\u5024\u306f\u300c\u6b20\u6e2c\u300d\u3068\u3057\u3066\u72ec\u7acb\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5206\u985e\u3057\u3001\u9664\u5916\u305b\u305a\u89e3\u6790\u306b\u542b\u3081\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/24830362_s.jpg\" alt=\"\u7d71\u8a08\" class=\"wp-image-12846\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24830362_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24830362_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7d71\u8a08\u89e3\u6790\u306b\u306f\u3001Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3057\u3001\u5168\u6b7b\u56e0\u3001CAD\u7279\u7570\u7684\u3001\u8133\u5352\u4e2d\u7279\u7570\u7684\u6b7b\u4ea1\u306b\u3064\u3044\u3066\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR: Hazard Ratio\uff09\u3092\u7b97\u51fa\u3057\u307e\u3057\u305f\u3002Kaplan\u2013Meier\u66f2\u7dda\u3068\u30ed\u30b0\u30e9\u30f3\u30af\u691c\u5b9a\u306b\u3088\u308a\u3001\u751f\u5b58\u66f2\u7dda\u306e\u5dee\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u5e74\u9f62\u306b\u3088\u308b\u4ea4\u4e92\u4f5c\u7528\u3082\u4e8b\u524d\u4eee\u8aac\u306b\u57fa\u3065\u304d\u8a55\u4fa1\u3055\u308c\u300171\u301c75\u6b73\u300176\u301c80\u6b73\u300180\u6b73\u8d85\u306e3\u7fa4\u3067\u5c64\u5225\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001FRS\u306b\u3088\u308bCAD\u6b7b\u4ea1\u4e88\u6e2c\u306e\u59a5\u5f53\u6027\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u300171\u301c80\u6b73\u306e\u53c2\u52a0\u8005\u306b\u5bfe\u3057\u3001FRS\u5358\u72ec\u30e2\u30c7\u30eb\u3068\u3001FRS\u306brs1333049\u306e\u907a\u4f1d\u60c5\u5831\u3092\u52a0\u3048\u305f\u30e2\u30c7\u30eb\uff08FRS+SNP\u30e2\u30c7\u30eb\uff09\u306710\u5e74\u4ee5\u5185\u306eCAD\u6b7b\u4ea1\u3092\u5206\u985e\u3057\u3001\u4e21\u8005\u306e\u4e88\u6e2c\u7cbe\u5ea6\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31556866_s.jpg\" alt=\"\u5065\u5eb7\" class=\"wp-image-12853\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31556866_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31556866_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u89e3\u6790\u5bfe\u8c61\u3068\u306a\u3063\u305f1,095\u540d\u306e\u3046\u3061\u3001278\u540d\uff0825%\uff09\u304cGG\u578b\u3001570\u540d\uff0852%\uff09\u304cGC\u578b\u3001247\u540d\uff0823%\uff09\u304cCC\u578b\u3067\u3057\u305f\u3002\u5408\u8a0810,218\u4eba\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u3001259\u540d\u304cCAD\u306b\u3088\u308a\u6b7b\u4ea1\u3057\u3001117\u540d\u304c\u8133\u5352\u4e2d\u306b\u3088\u308a\u6b7b\u4ea1\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5e74\u9f62\u3001\u6027\u5225\u3001\u55ab\u7159\u6b74\u3001BMI\u3001\u8840\u5727\u3001\u8102\u8cea\u3001\u7cd6\u5c3f\u75c5\u6b74\u306a\u3069\u306e\u5206\u5e03\u306f\u907a\u4f1d\u5b50\u578b\u9593\u3067\u6709\u610f\u306a\u5dee\u306f\u306a\u304f\u3001\u4ea4\u7d61\u306e\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/29940049_s.jpg\" alt=\"\u6551\u6025\u8eca\" class=\"wp-image-12860\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29940049_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29940049_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>CAD\u7279\u7570\u7684\u6b7b\u4ea1\u7387\u306f\u3001GG\u578b\u30671,000\u4eba\u5e74\u3042\u305f\u308a22\u4ef6\u3001GC\u578b\u306725\u4ef6\u3001CC\u578b\u306730\u4ef6\u3068\u3001C\u30a2\u30ec\u30eb\u306e\u30b3\u30d4\u30fc\u6570\u306b\u5fdc\u3058\u3066\u4e0a\u6607\u3057\u3001\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u3057\u305f\uff08P=0.01\uff09\u3002\u4e00\u65b9\u3001\u8133\u5352\u4e2d\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u306b\u6709\u610f\u306a\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>Cox\u56de\u5e30\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001C\u30a2\u30ec\u30eb1\u30b3\u30d4\u30fc\u3042\u305f\u308a\u306e\u5168\u6b7b\u56e0\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f19%\u5897\uff08HR: 1.19\u300195% CI: 1.08\u20131.30\u3001P&lt;0.01\uff09\u3001CAD\u7279\u7570\u7684\u6b7b\u4ea1\u30ea\u30b9\u30af\u306f29%\u5897\uff08HR: 1.29\u300195% CI: 1.08\u20131.56\u3001P&lt;0.01\uff09\u3067\u3057\u305f\u3002\u8133\u5352\u4e2d\u306b\u3088\u308b\u6b7b\u4ea1\u3068\u306e\u95a2\u9023\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08HR: 1.07\u3001P=0.63\uff09\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31692138_s-1.jpg\" alt=\"\u8a3a\u5bdf\" class=\"wp-image-12867\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31692138_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31692138_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>CAD\u6b7b\u4ea1\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u3068\u5e74\u9f62\u306e\u4ea4\u4e92\u4f5c\u7528\u306f\u6709\u610f\u3067\u3042\u308a\uff08P=0.05\uff09\u3001\u5e74\u9f62\u5c64\u5225\u89e3\u6790\u3067\u306f71\u301c75\u6b73\u7fa4\u3067HR: 1.59\uff08P=0.02\uff09\u300176\u301c80\u6b73\u7fa4\u3067HR: 1.52\uff08P=0.01\uff09\u3068\u30ea\u30b9\u30af\u5897\u52a0\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u304c\u300180\u6b73\u8d85\u3067\u306f\u6709\u610f\u306a\u95a2\u9023\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08HR: 1.02\u3001P=0.91\uff09\u3002<\/p>\n\n\n\n<p>10\u5e74\u4ee5\u5185\u306bCAD\u3067\u6b7b\u4ea1\u3057\u305f81\u540d\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30ea\u30b9\u30af\u5206\u985e\u89e3\u6790\u3067\u306f\u3001FRS\u5358\u72ec\u30e2\u30c7\u30eb\u3067\u306f17\u540d\uff0821%\uff09\u304c\u9ad8\u30ea\u30b9\u30af\u7fa4\u3068\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u304c\u3001FRS+SNP\u30e2\u30c7\u30eb\u3067\u306f22\u540d\uff0827%\uff09\u304c\u9ad8\u30ea\u30b9\u30af\u7fa4\u306b\u5206\u985e\u3055\u308c\u30016%\u306e\u518d\u5206\u985e\u6539\u5584\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001CAD\u672a\u8a3a\u65ad\u306e\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u3001\u67d3\u8272\u4f539p21\u306ers1333049\u30ea\u30b9\u30af\u30a2\u30ec\u30eb\u304c20\u5e74\u9593\u306e\u5168\u6b7b\u56e0\u304a\u3088\u3073CAD\u7279\u7570\u7684\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30ea\u30b9\u30af\u306f80\u6b73\u672a\u6e80\u3067\u9855\u8457\u306b\u8a8d\u3081\u3089\u308c\u3001\u305d\u308c\u4ee5\u964d\u3067\u306f\u6e1b\u5f31\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u306b\u52a0\u3048\u30669p21\u306e\u907a\u4f1d\u60c5\u5831\u3092\u52a0\u3048\u308b\u3053\u3068\u3067\u3001\u30d5\u30e9\u30df\u30f3\u30ac\u30e0\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u306e\u4e88\u6e2c\u7cbe\u5ea6\u304c\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u308f\u305a\u304b\u306b\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4344962_s.jpg\" alt=\"\u9ad8\u9f62\u5316\u793e\u4f1a\" class=\"wp-image-12874\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4344962_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4344962_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u9ad8\u9f62\u5316\u793e\u4f1a\u306b\u304a\u3051\u308bCAD\u306e\u4e88\u9632\u304a\u3088\u3073\u65e9\u671f\u4ecb\u5165\u306e\u91cd\u8981\u6027\u3092\u8e0f\u307e\u3048\u3001\u907a\u4f1d\u60c5\u5831\u306e\u6d3b\u7528\u306f\u81e8\u5e8a\u7684\u306b\u6709\u7528\u306a\u624b\u6bb5\u3068\u306a\u308a\u3046\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u5f8c\u306f\u3001\u3088\u308a\u5927\u898f\u6a21\u304b\u3064\u591a\u69d8\u306a\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8ffd\u8a66\u306b\u3088\u308a\u3001\u4eca\u56de\u306e\u6240\u898b\u306e\u4e00\u822c\u5316\u53ef\u80fd\u6027\u3068\u81e8\u5e8a\u5fdc\u7528\u6027\u3092\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u51a0\u52d5\u8108\u75be\u60a3\uff08coronary artery disease\uff09, \u907a\u4f1d\u7684\u5909\u7570\uff08genetic variation\uff09, \u5fc3\u7b4b\u6897\u585e\uff08myocardial infarction\uff09, \u751f\u5b58\u7387\uff08survival\uff09, \u30d5\u30e9\u30df\u30f3\u30ac\u30e0\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08Framingham Risk Score\uff09<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32168749_s.jpg\" alt=\"\u5e0c\u671b\" class=\"wp-image-12881\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32168749_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32168749_s-300x169.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1161\/CIRCGENETICS.111.960146\">Dutta, A., Henley, W., Lang, I. A., Murray, A., Guralnik, J., Wallace, R. B., &amp; Melzer, D. (2011). The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction.&nbsp;<em>Circulation. Cardiovascular genetics<\/em>,&nbsp;<em>4<\/em>(5), 542\u2013548. https:\/\/doi.org\/10.1161\/CIRCGENETICS.111.960146<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco&nbsp;Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u51a0\u52d5\u8108\u75be\u60a3\uff08CAD: Coronary Artery Disease\uff09\u306f\u3001\u52d5\u8108\u786c\u5316\u306b\u3088\u3063\u3066\u51a0\u52d5\u8108\u304c\u72ed\u7a84\u307e\u305f\u306f\u9589\u585e\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u7279\u306b\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u4e3b\u8981\u306a\u6b7b\u4ea1\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3001\u30b2\u30ce\u30e0\u30ef\u30a4 [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":12981,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[453,457,464,242,461,460,459,452,454,462,466,465,456,455,463,36,222,458,451],"class_list":["post-12765","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-9p21","tag-anril","tag-rs1333049","tag-snp","tag-461","tag-460","tag-459","tag-452","tag-454","tag-462","tag-466","tag-465","tag-456","tag-455","tag-463","tag-gene-testing","tag-222","tag-458","tag-451"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=12765"}],"version-history":[{"count":4,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12765\/revisions"}],"predecessor-version":[{"id":12888,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12765\/revisions\/12888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/12981"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=12765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=12765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=12765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}