{"id":12889,"date":"2025-04-07T01:13:29","date_gmt":"2025-04-07T01:13:29","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=12889"},"modified":"2025-04-07T01:22:22","modified_gmt":"2025-04-07T01:22:22","slug":"hyperten","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/hyperten\/","title":{"rendered":"\u8840\u5727\u3092\u6c7a\u3081\u308b\u306e\u306f\u809d\u81d3\uff1f\u305d\u308c\u3068\u3082\u814e\u81d3\uff1f\u2015\u907a\u4f1d\u5b50\u304c\u8a9e\u308b\u300c\u9ad8\u8840\u5727\u300d\u306e\u610f\u5916\u306a\u3057\u304f\u307f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<p>\u9ad8\u8840\u5727\uff08Hypertension, HTN\uff09\u306f\u3001\u52d5\u8108\u8840\u5727\u306e\u6301\u7d9a\u7684\u306a\u4e0a\u6607\u3092\u7279\u5fb4\u3068\u3059\u308b\u6162\u6027\u7684\u306a\u75be\u60a3\u3067\u3042\u308a\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u814e\u4e0d\u5168\u3001\u8133\u5352\u4e2d\u306a\u3069\u306e\u91cd\u5927\u306a\u5065\u5eb7\u554f\u984c\u306e\u4e3b\u8981\u306a\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e16\u754c\u7684\u306b\u7f79\u60a3\u7387\u30fb\u6b7b\u4ea1\u7387\u306e\u9ad8\u3044\u75be\u60a3\u306e\u3072\u3068\u3064\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u75c7\u306b\u306f\u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u8981\u56e0\u306e\u4e21\u65b9\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"731\" height=\"486\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P01019-F1.png\" alt=\"Angiotensinogen\" class=\"wp-image-12996\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P01019-F1.png 731w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P01019-F1-300x199.png 300w\" sizes=\"(max-width: 731px) 100vw, 731px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u8840\u5727\u306e\u8abf\u7bc0\u306b\u6df1\u304f\u95a2\u4e0e\u3059\u308b\u751f\u4f53\u30b7\u30b9\u30c6\u30e0\u306e\u3072\u3068\u3064\u304c\u3001\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\uff08Renin\u2013Angiotensin System, RAS\uff09\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u8840\u7ba1\u306e\u7dca\u5f35\uff08\u8840\u7ba1\u53ce\u7e2e\uff09\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u518d\u5438\u53ce\u3001\u4f53\u6db2\u91cf\u306e\u8abf\u6574\u306a\u3069\u306b\u95a2\u4e0e\u3059\u308b\u30db\u30eb\u30e2\u30f3\u30ab\u30b9\u30b1\u30fc\u30c9\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306eRAS\u306e\u4e2d\u5fc3\u306b\u4f4d\u7f6e\u3059\u308b\u306e\u304c\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\uff08Angiotensinogen, AGT\uff09\u3067\u3059\u3002AGT\u306f\u4e3b\u306b\u809d\u81d3\u3067\u5408\u6210\u30fb\u5206\u6ccc\u3055\u308c\u308b\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u814e\u81d3\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u9175\u7d20\u30ec\u30cb\u30f3\u306b\u3088\u3063\u3066\u5207\u65ad\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u307e\u305a\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3I\uff08Angiotensin I\uff09\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3I\u306f\u751f\u7406\u6d3b\u6027\u306e\u306a\u304410\u500b\u306e\u30a2\u30df\u30ce\u9178\u304b\u3089\u306a\u308b\u30da\u30d7\u30c1\u30c9\uff08\u30c7\u30ab\u30da\u30d7\u30c1\u30c9\uff09\u3067\u3059\u304c\u3001\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\uff08Angiotensin-Converting Enzyme, ACE\uff09\u306b\u3088\u3063\u3066\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\uff08Angiotensin II\uff09\u3068\u3044\u3046\u5f37\u529b\u306a\u8840\u7ba1\u53ce\u7e2e\u7269\u8cea\u3078\u3068\u5909\u63db\u3055\u308c\u307e\u3059\u3002\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u306f\u307e\u305f\u3001\u814e\u81d3\u3067\u306e\u30ca\u30c8\u30ea\u30a6\u30e0\u304a\u3088\u3073\u6c34\u306e\u518d\u5438\u53ce\u3092\u4fc3\u9032\u3057\u3001\u5faa\u74b0\u8840\u6db2\u91cf\u304a\u3088\u3073\u5168\u8eab\u8840\u5727\u306e\u4e0a\u6607\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/29318510_s.jpg\" alt=\"\u3061\u3085\u3071\" class=\"wp-image-13003\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29318510_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29318510_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u91cd\u8981\u306a\u70b9\u3068\u3057\u3066\u3001AGT\u306e\u767a\u73fe\u91cf\u304c\u308f\u305a\u304b\u306b\u5897\u52a0\u3057\u305f\u3060\u3051\u3067\u3082\u8840\u5727\u306e\u4e0a\u6607\u304c\u89b3\u5bdf\u3055\u308c\u308b\u3053\u3068\u304c\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u304b\u3089\u793a\u3055\u308c\u3066\u304a\u308a\u3001AGT\u306e\u5236\u5fa1\u304c\u8840\u5727\u8abf\u7bc0\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>AGT\u907a\u4f1d\u5b50\u5185\u306e2\u3064\u306e\u4e00\u5869\u57fa\u591a\u578b\uff08Single Nucleotide Polymorphisms, SNPs\uff09\u3001\u3059\u306a\u308f\u3061rs699\uff08A &gt; G\uff09\u304a\u3088\u3073rs5051\uff08C &gt; T\uff09\u306f\u3001\u9ad8\u8840\u5727\u3068\u306e\u95a2\u9023\u306b\u304a\u3044\u3066\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002rs699\u306f\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u3067\u3042\u308a\u3001AGT\u30bf\u30f3\u30d1\u30af\u8cea\u306e259\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u304c\u30e1\u30c1\u30aa\u30cb\u30f3\uff08Methionine, M\uff09\u304b\u3089\u30b9\u30ec\u30aa\u30cb\u30f3\uff08Threonine, T\uff09\u3078\u7f6e\u63db\u3055\u308c\u308b\u5909\u7570\u3067\u3059\u3002\u3053\u306e\u5909\u7570\u306f\u300cM235T\u300d\u3068\u3082\u547c\u3070\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001rs5051\u306fAGT\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u4f4d\u7f6e\u3057\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u6d3b\u6027\u3092\u5236\u5fa1\u3059\u308b\u914d\u5217\u3092\u5909\u5316\u3055\u305b\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306b\u3088\u308a\u3001rs699 A > G\u306f\u809d\u7279\u7570\u7684\u306a\u30de\u30a4\u30af\u30edRNA\uff08microRNA, miRNA\uff09\u306e\u3072\u3068\u3064\u3067\u3042\u308bmiR-122-5p\u306e\u7d50\u5408\u304c\u5f37\u307e\u308a\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066AGT\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002miRNAs\u306fmRNA\u306e\u7279\u5b9a\u914d\u5217\u306b\u7d50\u5408\u3057\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u77ed\u3044\u975e\u30b3\u30fc\u30c9RNA\u3067\u3059\u3002\u4e00\u65b9\u3067\u3001rs5051 C > T\u306f\u3001\u8ee2\u5199\u56e0\u5b50\uff08transcription factors\uff09\u306e\u7d50\u5408\u69d8\u5f0f\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3067\u3001AGT\u306e\u8ee2\u5199\uff08\u907a\u4f1d\u5b50\u767a\u73fe\uff09\u3092\u4fc3\u9032\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"783\" height=\"793\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/DNA0002.png\" alt=\"NIAID Visual &amp; Medical Arts. (08\/10\/2024). DNA. NIAID NIH BIOART Source. bioart.niaid.nih.gov\/bioart\/124\n\" class=\"wp-image-13010\" style=\"width:379px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/DNA0002.png 783w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/DNA0002-296x300.png 296w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/DNA0002-768x778.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><\/figure>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>rs699\u3068rs5051\u306f\u975e\u5e38\u306b\u5f37\u3044\u9023\u9396\u4e0d\u5e73\u8861\uff08Linkage Disequilibrium, LD\uff09\u306b\u3042\u308a\u3001\u3059\u306a\u308f\u3061\u67d3\u8272\u4f53\u4e0a\u3067\u4e92\u3044\u306b\u975e\u5e38\u306b\u8fd1\u3044\u4f4d\u7f6e\u306b\u3042\u308b\u305f\u3081\u3001\u540c\u6642\u306b\u907a\u4f1d\u3055\u308c\u3084\u3059\u3044\u3068\u3044\u3046\u7279\u5fb4\u3092\u6301\u3061\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u305d\u308c\u305e\u308c\u306e\u5909\u7570\u304c\u5358\u72ec\u3067\u8840\u5727\u3084AGT\u767a\u73fe\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u660e\u78ba\u306b\u533a\u5225\u3057\u3066\u8abf\u3079\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u72b6\u6cc1\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u3053\u308c\u30892\u3064\u306eSNP\u304c\u72ec\u7acb\u3057\u3066\u907a\u4f1d\u3055\u308c\u305f\u5834\u5408\u3001\u305d\u308c\u305e\u308c\u304cAGT\u306e\u767a\u73fe\u304a\u3088\u3073\u9ad8\u8840\u5727\u306e\u30ea\u30b9\u30af\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001\u7247\u65b9\u306e\u5909\u7570\u304c\u3082\u3046\u4e00\u65b9\u306b\u3088\u308b\u5f71\u97ff\u3092\u300c\u6253\u3061\u6d88\u3055\u306a\u3044\u300d\u3088\u3046\u306a\u975e\u5bfe\u79f0\u7684\u306a\u907a\u4f1d\u578b\uff08unbalanced genotype\uff09\u3092\u6301\u3064\u500b\u4f53\u3067\u306f\u3001\u8840\u5727\u3084\u9ad8\u8840\u5727\u30ea\u30b9\u30af\u306b\u660e\u78ba\u306a\u5909\u5316\u304c\u898b\u3089\u308c\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u4eee\u8aac\u306e\u3082\u3068\u306b\u7814\u7a76\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<p>AGT\u907a\u4f1d\u5b50\u306f\u3001RAS\u30ab\u30b9\u30b1\u30fc\u30c9\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\uff08Angiotensinogen\uff09\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002AGT\u306e\u907a\u4f1d\u7684\u591a\u578b\u306b\u3088\u308a\u3001\u8ee2\u5199\u3055\u308c\u308bmRNA\u3084\u5408\u6210\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cf\u304c\u5909\u5316\u3057\u3001\u305d\u308c\u304c\u5168\u8eab\u306e\u8840\u5727\u8abf\u7bc0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001rs699\u304a\u3088\u3073rs5051\u3068\u3044\u30462\u3064\u306eSNP\u3067\u3042\u308a\u3001\u3053\u308c\u3089\u306fAGT\u306e\u767a\u73fe\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs699-hgtIdeo_genome_1f6b63_322ba0-1024x25.png\" alt=\"rs699\" class=\"wp-image-12896\" style=\"width:819px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs699-hgtIdeo_genome_1f6b63_322ba0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs699-hgtIdeo_genome_1f6b63_322ba0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs699-hgtIdeo_genome_1f6b63_322ba0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs699-hgtIdeo_genome_1f6b63_322ba0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs5051-hgtIdeo_genome_1f8d66_322f40-1024x25.png\" alt=\"rs5051\" class=\"wp-image-12903\" style=\"width:819px;height:auto\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs5051-hgtIdeo_genome_1f8d66_322f40-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs5051-hgtIdeo_genome_1f8d66_322f40-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs5051-hgtIdeo_genome_1f8d66_322f40-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs5051-hgtIdeo_genome_1f8d66_322f40.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>rs699\uff08A &gt; G\uff09\u306f\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u3067\u3042\u308a\u3001DNA\u914d\u5217\u4e2d\u306e\u30a2\u30c7\u30cb\u30f3\uff08A\uff09\u304c\u30b0\u30a2\u30cb\u30f3\uff08G\uff09\u306b\u7f6e\u304d\u63db\u308f\u308b\u3053\u3068\u3067\u3001AGT\u30bf\u30f3\u30d1\u30af\u8cea\u306e259\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u304c\u30e1\u30c1\u30aa\u30cb\u30f3\uff08M\uff09\u304b\u3089\u30b9\u30ec\u30aa\u30cb\u30f3\uff08T\uff09\u3078\u3068\u5909\u5316\u3057\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u306f\u30ec\u30cb\u30f3\uff08Renin\uff09\u306e\u7d50\u5408\u90e8\u4f4d\u306b\u306f\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u3044\u305f\u3081\u3001AGT\u306e\u5207\u65ad\u306b\u306f\u76f4\u63a5\u95a2\u4e0e\u3057\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001miRNA\u3001\u7279\u306b\u809d\u81d3\u7d30\u80de\uff08\u809d\u7d30\u80de\uff09\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308bmiR-122-5p\u3068\u306e\u7d50\u5408\u306b\u3088\u308a\u3001mRNA\u306e\u5b89\u5b9a\u6027\u3084\u5206\u89e3\u901f\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001rs5051\uff08C > T\uff09\u306fAGT\u907a\u4f1d\u5b50\u306e\u30b3\u30fc\u30c9\u9818\u57df\u3088\u308a\u4e0a\u6d41\u306b\u3042\u308b\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u4f4d\u7f6e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u9818\u57df\u306b\u306f\u3001DNA\u304b\u3089mRNA\u3078\u306e\u8ee2\u5199\u3092\u958b\u59cb\u30fb\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u304c\u7d50\u5408\u3059\u308b\u90e8\u4f4d\u304c\u591a\u6570\u5b58\u5728\u3057\u307e\u3059\u3002C > T\u5909\u7570\u306f\u3001\u7279\u5b9a\u306e\u8ee2\u5199\u6d3b\u6027\u5316\u56e0\u5b50\u306b\u5bfe\u3059\u308b\u7d50\u5408\u89aa\u548c\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001AGT\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u91cf\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"732\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo1-MfZSFVOSLeYNODMfDUAAAdXS.png\" alt=\"chromo1\" class=\"wp-image-12910\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo1-MfZSFVOSLeYNODMfDUAAAdXS.png 732w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo1-MfZSFVOSLeYNODMfDUAAAdXS-300x205.png 300w\" sizes=\"(max-width: 732px) 100vw, 732px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u30892\u3064\u306eSNP\u306f\u5f37\u3044\u9023\u9396\u4e0d\u5e73\u8861\uff08LD\uff09\u306b\u3042\u308a\u3001LD\u306e\u6307\u6a19\u3067\u3042\u308br\u00b2\u306f0.94\u3068\u975e\u5e38\u306b\u9ad8\u3044\u5024\u3092\u793a\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u300190%\u4ee5\u4e0a\u306e\u78ba\u7387\u3067\u540c\u6642\u306b\u907a\u4f1d\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5168\u4f53\u306e\u7d042\u301c3%\u306e\u500b\u4eba\u306b\u304a\u3044\u3066\u306f\u3001\u3053\u308c\u3089\u306e\u5909\u7570\u304c\u300c\u975e\u5bfe\u79f0\u578b\uff08unbalanced\uff09\u300d\u3001\u3059\u306a\u308f\u3061\u4e00\u65b9\u306e\u5909\u7570\u3092\u6301\u3061\u3001\u4ed6\u65b9\u3092\u6301\u305f\u306a\u3044\u72b6\u614b\u3067\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u7a00\u306a\u907a\u4f1d\u578b\u3092\u6301\u3064\u500b\u4f53\u306f\u3001\u305d\u308c\u305e\u308c\u306eSNP\u304cAGT\u306e\u767a\u73fe\u304a\u3088\u3073\u9ad8\u8840\u5727\u8868\u73fe\u578b\u306b\u4e0e\u3048\u308b\u72ec\u7acb\u3057\u305f\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b\u4e0a\u3067\u8cb4\u91cd\u306a\u7814\u7a76\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/598911_s.jpg\" alt=\"Strong Linkage Disequilibrium \u305a\u3063\u3068\u4e00\u7dd2\u306b\u3044\u3088\u3046\" class=\"wp-image-12917\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/598911_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/598911_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"183\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-1024x183.png\" alt=\"\u907a\u4f1d\u5909\u7570\" class=\"wp-image-12796\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-1024x183.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-300x54.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-768x137.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-1536x274.png 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001-2048x365.png 2048w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GeneMutation0001.png 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001AGT\u907a\u4f1d\u5b50\u5185\u306ers699\uff08A &gt; G\uff09\u304a\u3088\u3073rs5051\uff08C &gt; T\uff09\u304cAGT\u306e\u767a\u73fe\u306b\u5bfe\u3057\u3066\u62ee\u6297\u7684\u306a\u5f71\u97ff\u3092\u6301\u3061\u3001\u3053\u308c\u3089\u304c\u72ec\u7acb\u3057\u3066\u907a\u4f1d\u3055\u308c\u308b\u5834\u5408\u306b\u8840\u5727\u3084\u9ad8\u8840\u5727\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002\u4eee\u8aac\u3068\u3057\u3066\u306f\u3001rs699 A &gt; G\u306fmiR-122-5p\u3068\u306e\u7d50\u5408\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u3067AGT mRNA\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u4e00\u65b9\u3067\u3001rs5051 C &gt; T\u306f\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u8ee2\u5199\u91cf\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u7247\u65b9\u306e\u5f71\u97ff\u304c\u4ed6\u65b9\u306b\u3088\u3063\u3066\u6253\u3061\u6d88\u3055\u308c\u306a\u3044\u3088\u3046\u306a\u300c\u975e\u5bfe\u79f0\u578b\u300d\u907a\u4f1d\u578b\u3092\u6301\u3064\u500b\u4f53\u3067\u306f\u3001\u8840\u5727\u306b\u5bfe\u3059\u308b\u6709\u610f\u306a\u5909\u5316\u304c\u73fe\u308c\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u8a08\u7b97\u89e3\u6790\uff08in silico\uff09\u3067\u306f\u3001rs699\u306eG\u30a2\u30ec\u30eb\u306fmiR-122-5p\u3068\u306e\u7d50\u5408\u89aa\u548c\u6027\u3092\u7d043%\uff08\u81ea\u7531\u30a8\u30cd\u30eb\u30ae\u30fc\u0394G\u306e1 kcal\/mol\u4f4e\u4e0b\uff09\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001miRNA\u3068\u6a19\u7684mRNA\u3068\u306e\u7d50\u5408\u90e8\u4f4d\u3092\u7279\u5b9a\u3059\u308b\u5b9f\u9a13\u6280\u8853\u3067\u3042\u308bMir-eCLIP\uff08enhanced crosslinking and immunoprecipitation\uff09\u306b\u3088\u308a\u3001rs699\u304cAGT mRNA\u5185\u306e\u6700\u3082\u5f37\u3044miRNA\u7d50\u5408\u30d4\u30fc\u30af\u304b\u308940\uff5e45\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u96e2\u308c\u305f\u4f4d\u7f6e\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u4f4d\u7f6e\u95a2\u4fc2\u306f\u3001miRNA\u306b\u3088\u308b\u9593\u63a5\u7684\u306a\u5236\u5fa1\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968510_s.jpg\" alt=\"\u30d4\u30da\u30c3\u30c8\" class=\"wp-image-12924\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968510_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968510_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e88\u60f3\u306b\u53cd\u3057\u3066\u3001HepG2\uff08\u809d\u81d3\u7d30\u80de\u682a\uff09\u3092\u7528\u3044\u305fin vitro\uff08\u8a66\u9a13\u7ba1\u5185\uff09\u5b9f\u9a13\u3067\u306f\u3001rs699 A &gt; G\u306fAGT mRNA\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001HT29\uff08\u7d50\u8178\u7d30\u80de\u682a\uff09\u3067\u306fAGT\u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u3001HEK293\uff08\u814e\u81d3\u7d30\u80de\u682a\uff09\u3067\u306f\u6709\u610f\u306a\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001rs699 A &gt; G\u306e\u52b9\u679c\u304c\u7d44\u7e54\u4f9d\u5b58\u7684\u3067\u3042\u308a\u3001\u7d30\u80de\u578b\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>GTEx\uff08Genotype-Tissue Expression\uff09\u30c7\u30fc\u30bf\u306b\u3088\u308b\u3068\u3001AGT\u306e\u767a\u73fe\u91cf\u306f\u809d\u81d3\u3067\u306fSNP\u306e\u5f71\u97ff\u3092\u307b\u3068\u3093\u3069\u53d7\u3051\u3066\u3044\u306a\u3044\u4e00\u65b9\u3067\u3001\u814e\u76ae\u8cea\uff08kidney cortex\uff09\u3067\u306frs699 G\u30a2\u30ec\u30eb\u304c\u6709\u610f\u306a\u767a\u73fe\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u814e\u81d3\u306f\u3001\u30ec\u30cb\u30f3\uff08REN\uff09\u3001ACE\u3001\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u53d7\u5bb9\u4f53\uff08AGTR1\uff09\u3068\u3044\u3063\u305fRAS\u306e\u5168\u69cb\u6210\u8981\u7d20\u3092\u5c40\u6240\u7684\u306b\u767a\u73fe\u3057\u3066\u304a\u308a\u3001AGT\u306e\u5c40\u6240\u7684\uff08\u30d1\u30e9\u30af\u30ea\u30f3\u578b\uff09\u767a\u73fe\u304c\u8840\u5727\u8abf\u7bc0\u306b\u76f4\u63a5\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"712\" height=\"273\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-1.png\" alt=\"Type-1 angiotensin II receptor\" class=\"wp-image-12931\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-1.png 712w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-1-300x115.png 300w\" sizes=\"(max-width: 712px) 100vw, 712px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>UK Biobank\u306e\u5927\u898f\u6a21\u30c7\u30fc\u30bf\u89e3\u6790\u3067\u306f\u3001rs699 A &gt; G\u304a\u3088\u3073rs5051 C &gt; T\u306e\u5404\u30a2\u30ec\u30eb\u304c\u3001\u53ce\u7e2e\u671f\u8840\u5727\uff08systolic blood pressure\uff09\u3092\u305d\u308c\u305e\u308c\u7d040.36 mmHg\u4e0a\u6607\u3055\u305b\u308b\u6709\u610f\u306a\u95a2\u9023\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u52b9\u679c\u91cf\u306f\u5c0f\u3055\u3044\u3082\u306e\u306e\u3001\u9ed2\u4eba\u53c2\u52a0\u8005\u3067\u306f\u767d\u4eba\u306e4\u500d\u8fd1\u3044\u52b9\u679c\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u9ed2\u4eba\u306b\u304a\u3051\u308brs5051 T\u30a2\u30ec\u30eb\u306e\u983b\u5ea6\u304c88%\u3068\u9ad8\u3044\u306e\u306b\u5bfe\u3057\u3001\u767d\u4eba\u3067\u306f40%\u3067\u3042\u308b\u3068\u3044\u3046\u30a2\u30ec\u30eb\u983b\u5ea6\u306e\u9055\u3044\u304a\u3088\u3073LD\u69cb\u9020\u306e\u9055\u3044\u306b\u3088\u308a\u8aac\u660e\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001AGT\u306b\u3088\u308b\u8840\u5727\u8abf\u7bc0\u304c\u5f93\u6765\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u809d\u81d3\u4e2d\u5fc3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u52a0\u3048\u3066\u3001\u814e\u81d3\u306b\u304a\u3051\u308b\u5c40\u6240\u7684\u306a\u5236\u5fa1\u3082\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u7279\u306b\u30a2\u30d5\u30ea\u30ab\u7cfb\u96c6\u56e3\u306b\u304a\u3051\u308b\u81e8\u5e8a\u7684\u610f\u7fa9\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u5f93\u6765\u306e\u300c\u4eba\u7a2e\u306b\u57fa\u3065\u304f\u6cbb\u7642\u300d\u304b\u3089\u3001\u907a\u4f1d\u5b50\u578b\uff08genotype\uff09\u306b\u57fa\u3065\u3044\u305f\u500b\u5225\u5316\u6cbb\u7642\uff08personalized therapy\uff09\u3078\u306e\u79fb\u884c\u306e\u5fc5\u8981\u6027\u3092\u652f\u6301\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u4ee5\u4e0b\u306e4\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u591a\u89d2\u7684\u306a\u89e3\u6790\u624b\u6cd5\uff08\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30eb\u30fb\u30b9\u30bf\u30c7\u30a3\u30c7\u30b6\u30a4\u30f3\uff09\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-1.jpg\" alt=\"\u30c7\u30fc\u30bf\u89e3\u6790\" class=\"wp-image-12938\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a4\u30f3\u30fb\u30b7\u30ea\u30b3\u89e3\u6790\uff08in silico\uff09<\/strong><br>RNA\u306e\u4e8c\u6b21\u69cb\u9020\u4e88\u6e2c\u304a\u3088\u3073\u7d50\u5408\u89aa\u548c\u6027\u8a55\u4fa1\u306b\u7279\u5316\u3057\u305fViennaRNA\u30d1\u30c3\u30b1\u30fc\u30b8\u306e\u4e00\u90e8\u3067\u3042\u308bRNAduplex\u3092\u7528\u3044\u3066\u3001miR-122-5p\u304cAGT mRNA\u306b\u7d50\u5408\u3059\u308b\u969b\u306e\u81ea\u7531\u30a8\u30cd\u30eb\u30ae\u30fc\u5909\u5316\uff08\u0394G\uff09\u3092\u7b97\u51fa\u3057\u307e\u3057\u305f\u3002rs699\u306eA\u30a2\u30ec\u30eb\u304a\u3088\u3073G\u30a2\u30ec\u30eb\u306e\u4e21\u65b9\u306b\u3064\u3044\u3066\u3001\u0394G\u306e\u4f4e\u4e0b\u91cf\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3067\u7d50\u5408\u306e\u5f37\u3055\uff08\u89aa\u548c\u6027\uff09\u3092\u63a8\u5b9a\u3057\u307e\u3057\u305f\u3002\u0394G\u304c\u5c0f\u3055\u3044\u307b\u3069\u3001miRNA\u3068mRNA\u306e\u7d50\u5408\u306f\u5f37\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30fb\u30d3\u30c8\u30ed\u5b9f\u9a13\uff08in vitro\uff09<\/strong><br>AGT\u907a\u4f1d\u5b50\u3092\u30b3\u30fc\u30c9\u3059\u308bcDNA\u69cb\u7bc9\u4f53\uff08rs699 A\u578b\uff1d\u91ce\u751f\u578b\u304a\u3088\u3073G\u578b\uff1d\u5909\u7570\u578b\uff09\u30923\u7a2e\u985e\u306e\u30d2\u30c8\u7d30\u80de\u682a\u306b\u5c0e\u5165\uff08\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\uff09\u3057\u307e\u3057\u305f\u3002\u4f7f\u7528\u3055\u308c\u305f\u7d30\u80de\u682a\u306f\u3001HepG2\uff08\u809d\u7d30\u80de\u682a\uff09\u3001HT29\uff08\u7d50\u8178\u4e0a\u76ae\u7d30\u80de\u682a\uff09\u3001HEK293\uff08\u814e\u7531\u6765\u7d30\u80de\u682a\uff09\u3067\u3059\u3002AGT mRNA\u306e\u767a\u73fe\u91cf\u306f\u5b9a\u91cf\u7684\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\uff08qPCR\uff09\u306b\u3088\u308a\u6e2c\u5b9a\u3055\u308c\u3001\u30cf\u30a6\u30b9\u30ad\u30fc\u30d4\u30f3\u30b0\u907a\u4f1d\u5b50GAPDH\u306b\u5bfe\u3057\u3066\u6b63\u898f\u5316\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30fb\u30d3\u30dc\u30c7\u30fc\u30bf\u89e3\u6790\uff08in vivo\uff09<\/strong><br>GTEx\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08Genotype-Tissue Expression, \u7b2c8\u7248\uff09\u306eRNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001rs699\u304a\u3088\u3073rs5051\u306e\u907a\u4f1d\u5b50\u578b\u3054\u3068\u306eAGT\u767a\u73fe\u91cf\u304a\u3088\u3073\u767a\u73fe\u5b9a\u91cf\u7684\u907a\u4f1d\u5b50\u5ea7\uff08expression Quantitative Trait Loci, eQTL\uff09\u52b9\u679c\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u809d\u81d3\u3001\u814e\u81d3\u3001\u52d5\u8108\u306a\u3069\u8907\u6570\u306e\u7d44\u7e54\u306b\u304a\u3044\u3066\u3001\u907a\u4f1d\u5b50\u578b\u3068\u767a\u73fe\u91cf\u306e\u76f8\u95a2\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li><strong>\u81e8\u5e8a\u304a\u3088\u3073\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u89e3\u6790<\/strong><br>\u81e8\u5e8a\u30c7\u30fc\u30bf\u306f\u3001\u30a4\u30f3\u30c7\u30a3\u30a2\u30ca\u5927\u5b66\u9ad8\u5ea6\u7cbe\u5bc6\u30b2\u30ce\u30df\u30af\u30b9\u30b3\u30db\u30fc\u30c8\uff08Advanced Precision Genomics, APG\uff09\u304a\u3088\u3073\u82f1\u56fd\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\uff08UK Biobank\uff09\u304b\u3089\u53d6\u5f97\u3055\u308c\u307e\u3057\u305f\u3002APG\u30b3\u30db\u30fc\u30c8\u3067\u306f\u3001\u9ad8\u8840\u5727\u306e\u91cd\u75c7\u5ea6\u306e\u4ee3\u66ff\u6307\u6a19\u3068\u3057\u3066\u964d\u5727\u85ac\u306e\u51e6\u65b9\u8a18\u9332\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002UK Biobank\u3067\u306f\u3001\u7d0446\u4e072\u5343\u4eba\u306e\u53c2\u52a0\u8005\u304b\u3089\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u3092\u3082\u3068\u306b\u3001\u907a\u4f1d\u5b50\u578b\u3068\u8840\u5727\u306e\u95a2\u4fc2\u304c\u5e74\u9f62\u3001\u6027\u5225\u3001BMI\uff08\u4f53\u683c\u6307\u6570\uff09\u3001\u751f\u6d3b\u7fd2\u6163\u3001\u5404\u7a2e\u751f\u5316\u5b66\u6307\u6a19\u306a\u3069\u306e\u4ea4\u7d61\u56e0\u5b50\u3092\u88dc\u6b63\u3057\u305f\u3046\u3048\u3067\u7d71\u8a08\u89e3\u6790\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2.jpg\" alt=\"\u5b9f\u9a13\u7ba1\" class=\"wp-image-12945\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7d71\u8a08\u89e3\u6790\u306b\u306f\u3001\u7dda\u5f62\u56de\u5e30\u3001\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u3001Z\u30b9\u30b3\u30a2\u6b63\u898f\u5316\u306a\u3069\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u89e3\u6790\u306f\u5e74\u9f62\u3001\u85ac\u5264\u4f7f\u7528\u3001\u4eba\u7a2e\u30fb\u6c11\u65cf\uff08\u81ea\u5df1\u7533\u544a\uff09\u306b\u3088\u3063\u3066\u5c64\u5225\u5316\u3055\u308c\u307e\u3057\u305f\u3002rs5051\u306b\u95a2\u3057\u3066\u306f\u3001\u30a4\u30f3\u30d4\u30e5\u30fc\u30c6\u30fc\u30b7\u30e7\u30f3\uff08\u6b20\u640d\u88dc\u5b8c\uff09\u3055\u308c\u305f\u907a\u4f1d\u5b50\u578b\u30c7\u30fc\u30bf\u304c\u300c\u6700\u5c24\u63a8\u5b9a\u578b\uff08best-guess\uff09\u300d\u306b\u5909\u63db\u3055\u308c\u3001\u30ab\u30c6\u30b4\u30ea\u5909\u6570\u3068\u3057\u3066\u30e2\u30c7\u30eb\u5316\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"692\" height=\"309\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-2.png\" alt=\"Type-1 angiotensin II receptor\" class=\"wp-image-12952\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-2.png 692w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-2-300x134.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u8a08\u7b97\u30e2\u30c7\u30eb\u306b\u3088\u308bin silico\u89e3\u6790\u3067\u306f\u3001rs699 A &gt; G\u306b\u3088\u3063\u3066miR-122-5p\u3068AGT mRNA\u306e\u7d50\u5408\u89aa\u548c\u6027\u304c\u3084\u3084\u5f37\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u81ea\u7531\u30a8\u30cd\u30eb\u30ae\u30fc\u0394G\u304c\u7d041 kcal\/mol\u6e1b\u5c11\uff09\u3002\u3053\u308c\u306f\u3001G\u30a2\u30ec\u30eb\u306e\u5b58\u5728\u306b\u3088\u3063\u3066miRNA\u306b\u3088\u308b\u5236\u5fa1\u304c\u5f37\u307e\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u307e\u3059\u3002Mir-eCLIP\u5b9f\u9a13\u3067\u306f\u3001rs699\u304cAGT mRNA\u5185\u306e\u4e3b\u8981\u306amiRNA\u7d50\u5408\u30d4\u30fc\u30af\u306e\u3059\u3050\u8fd1\u508d\uff08\u7d0440\u301c45\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u96e2\u308c\u305f\u4f4d\u7f6e\uff09\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3001\u6a5f\u80fd\u7684\u95a2\u9023\u6027\u306e\u53ef\u80fd\u6027\u304c\u652f\u6301\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>in vitro\u5b9f\u9a13\u3067\u306f\u3001rs699 A > G\u306e\u52b9\u679c\u306f\u7d44\u7e54\u4f9d\u5b58\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002HepG2\uff08\u809d\u7d30\u80de\uff09\u3067\u306fAGT mRNA\u767a\u73fe\u304c\u7d041.8\u500d\u306b\u5897\u52a0\u3057\u305f\u4e00\u65b9\u3067\u3001HT29\uff08\u7d50\u8178\u7d30\u80de\uff09\u3067\u306f\u7d042\u500d\u306e\u767a\u73fe\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002HEK293\uff08\u814e\u7d30\u80de\uff09\u3067\u306f\u6709\u610f\u306a\u5909\u5316\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u907a\u4f1d\u5b50\u5909\u7570\u306e\u6a5f\u80fd\u304c\u7d30\u80de\u578b\u7279\u7570\u7684\uff08cell-type specific\uff09\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/30285039_s.jpg\" alt=\"\u9855\u5fae\u93e1\u3067\u30c1\u30e9\u30c3\u3068\" class=\"wp-image-12959\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30285039_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30285039_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>GTEx\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u3067\u306f\u3001\u809d\u81d3\u3067\u306f\u3044\u305a\u308c\u306eSNP\u3082AGT\u767a\u73fe\u306b\u6709\u610f\u306a\u5f71\u97ff\u3092\u793a\u3055\u306a\u304b\u3063\u305f\u4e00\u65b9\u3001\u814e\u76ae\u8cea\u306b\u304a\u3044\u3066\u306frs699 G\u30a2\u30ec\u30eb\u3092\u6709\u3059\u308b\u500b\u4f53\u3067AGT\u767a\u73fe\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\uff08p = 0.049\uff09\u3002\u3053\u306e\u6240\u898b\u306f\u3001\u814e\u81d3\u306b\u304a\u3051\u308b\u5c40\u6240\u7684\u306aAGT\u767a\u73fe\u304crs699\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>UK Biobank\u30c7\u30fc\u30bf\u3067\u306f\u3001rs699 A > G\u304a\u3088\u3073rs5051 C > T\u306e\u305d\u308c\u305e\u308c\u304c\u3001\u53ce\u7e2e\u671f\u8840\u5727\u3092\u308f\u305a\u304b\u306b\uff08\u7d040.36 mmHg\/\u30a2\u30ec\u30eb\uff09\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u304c\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u793a\u3055\u308c\u307e\u3057\u305f\uff08p &lt; 0.001\uff09\u3002\u52b9\u679c\u91cf\u306f\u5c0f\u3055\u3044\u3082\u306e\u306e\u3001\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u306b\u3088\u308a\u3001rs5051 C > T\u306e\u52b9\u679c\u306f\u9ed2\u4eba\u53c2\u52a0\u8005\u3067\u306f1.17 mmHg\u3068\u3001\u767d\u4eba\u53c2\u52a0\u8005\u306e4\u500d\u4ee5\u4e0a\uff080.25 mmHg\uff09\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001rs5051 T\u30a2\u30ec\u30eb\u306e\u983b\u5ea6\u306f\u9ed2\u4eba\u3067\u306f88%\u3001\u767d\u4eba\u3067\u306f40%\u3068\u3001\u96c6\u56e3\u9593\u3067\u5927\u304d\u306a\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001AGT\u907a\u4f1d\u5b50\u5185\u306eSNP\u3001rs699\uff08A > G\uff09\u304a\u3088\u3073rs5051\uff08C > T\uff09\u304cAGT\u306e\u767a\u73fe\u304a\u3088\u3073\u53ce\u7e2e\u671f\u8840\u5727\u306e\u4e0a\u6607\u3068\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u95a2\u9023\u3092\u793a\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u7279\u306b\u3001rs699 A > G\u306b\u3064\u3044\u3066\u306f\u3001\u5f53\u521d\u306e\u4eee\u8aac\u306b\u53cd\u3057\u3066AGT\u306e\u767a\u73fe\u3092\u4e00\u8cab\u3057\u3066\u6291\u5236\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u7d30\u80de\u578b\u306b\u4f9d\u5b58\u3057\u305f\u591a\u69d8\u306a\u52b9\u679c\u3092\u6301\u3064\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u809d\u7d30\u80de\u3067\u306f\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u3001\u7d50\u8178\u7d30\u80de\u3067\u306f\u6e1b\u5c11\u3055\u305b\u308b\u306a\u3069\u3001\u305d\u306e\u6a5f\u80fd\u306f\u7d44\u7e54\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3053\u3068\u304c\u660e\u78ba\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"705\" height=\"315\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-3.png\" alt=\"Type-1 angiotensin II receptor\" class=\"wp-image-12966\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-3.png 705w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P30556-F1-3-300x134.png 300w\" sizes=\"(max-width: 705px) 100vw, 705px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u814e\u76ae\u8cea\u306f\u8840\u5727\u8abf\u7bc0\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u89e3\u5256\u5b66\u7684\u90e8\u4f4d\u3067\u3042\u308a\u3001\u672c\u7814\u7a76\u3067\u306f\u3053\u306e\u90e8\u4f4d\u306b\u304a\u3044\u3066rs699 G\u30a2\u30ec\u30eb\u306b\u3088\u308bAGT\u767a\u73fe\u4e0a\u6607\u304c\u6700\u3082\u4e00\u8cab\u3057\u3066\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5f93\u6765\u306e\u300cAGT\u306f\u4e3b\u306b\u809d\u81d3\u7531\u6765\u3067\u5168\u8eab\u306b\u4f5c\u7528\u3059\u308b\u300d\u3068\u3044\u3046\u5b9a\u8aac\u3092\u518d\u8003\u3055\u305b\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u814e\u81d3\u306b\u304a\u3051\u308b\u5c40\u6240\u7684\u306aRAS\u6d3b\u6027\uff08\u30d1\u30e9\u30af\u30ea\u30f3\u5236\u5fa1\uff09\u306e\u81e8\u5e8a\u7684\u91cd\u8981\u6027\u3092\u5f37\u8abf\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u7684\u5909\u7570\u306f\u9ed2\u4eba\u96c6\u56e3\u306b\u304a\u3044\u3066\u3088\u308a\u9ad8\u983b\u5ea6\u304b\u3064\u9ad8\u3044\u8868\u73fe\u578b\u52b9\u679c\u3092\u793a\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u4eba\u7a2e\u306b\u57fa\u3065\u304f\u753b\u4e00\u7684\u306a\u6cbb\u7642\u65b9\u91dd\u3067\u306f\u306a\u304f\u3001\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u3044\u305f\u500b\u5225\u5316\u6cbb\u7642\uff08genotype-guided precision therapy\uff09\u306e\u5fc5\u8981\u6027\u304c\u6539\u3081\u3066\u6d6e\u304d\u5f6b\u308a\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30ce\u30fc\u30b2\u30f3\uff08angiotensinogen\uff09\u3001\u4e00\u5869\u57fa\u591a\u578brs699\uff08rs699\uff09\u3001\u4e00\u5869\u57fa\u591a\u578brs5051\uff08rs5051\uff09\u3001\u9ad8\u8840\u5727\uff08hypertension\uff09\u3001\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\uff08renin\u2013angiotensin system\uff09\u3001\u30de\u30a4\u30af\u30edRNA\uff08microRNA\uff09\u3001miR-122-5p\u3001AGT\u767a\u73fe\uff08AGT expression\uff09\u3001\u9023\u9396\u4e0d\u5e73\u8861\uff08linkage disequilibrium\uff09\u3001\u814e\u76ae\u8cea\uff08kidney cortex\uff09\u3001\u7d30\u80de\u578b\u7279\u7570\u6027\uff08cell-type specificity\uff09\u3001\u82f1\u56fd\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\uff08UK Biobank\uff09\u3001\u907a\u4f1d\u5b50\u7d44\u7e54\u767a\u73fe\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08GTEx\uff09\u3001\u8840\u5727\uff08blood pressure\uff09\u3001\u4eba\u7a2e\u306b\u57fa\u3065\u304f\u533b\u7642\uff08race-based medicine\uff09\u3001\u500b\u5225\u5316\u6cbb\u7642\uff08personalized therapy\uff09<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"360\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/29705346_s.jpg\" alt=\"\u9ed2\u4eba\u5973\u6027\" class=\"wp-image-12973\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29705346_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/29705346_s-300x169.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1002\/cdt3.103\">Powell, N. R., Shugg, T., Leighty, J., Martin, M., Kreutz, R. P., Eadon, M. T., Lai, D., Lu, T., &amp; Skaar, T. C. (2023). Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension.\u00a0<em>Chronic diseases and translational medicine<\/em>,\u00a0<em>10<\/em>(2), 102\u2013117. https:\/\/doi.org\/10.1002\/cdt3.103<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/bioart.niaid.nih.gov\/bioart\/124\">NIAID Visual &amp; Medical Arts. (08\/10\/2024). DNA. NIAID NIH BIOART Source. bioart.niaid.nih.gov\/bioart\/124<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u9ad8\u8840\u5727\uff08Hypertension, HTN\uff09\u306f\u3001\u52d5\u8108\u8840\u5727\u306e\u6301\u7d9a\u7684\u306a\u4e0a\u6607\u3092\u7279\u5fb4\u3068\u3059\u308b\u6162\u6027\u7684\u306a\u75be\u60a3\u3067\u3042\u308a\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u814e\u4e0d\u5168\u3001\u8133\u5352\u4e2d\u306a\u3069\u306e\u91cd\u5927\u306a\u5065\u5eb7\u554f\u984c\u306e\u4e3b\u8981\u306a\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e16\u754c\u7684\u306b\u7f79 [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":12988,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[468,479,472,478,467,242,483,476,481,484,473,225,487,474,477,486,490,471,480,485,469,475,482,59,488,470],"class_list":["post-12889","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-agt","tag-gtex","tag-mir-122-5p","tag-rs5051","tag-rs699","tag-snp","tag-uk-biobank","tag-476","tag-481","tag-rna","tag-473","tag-225","tag-487","tag-474","tag-477","tag-486","tag-490","tag-471","tag-480","tag-485","tag-469","tag-475","tag-482","tag-59","tag-488","tag-470"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12889","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=12889"}],"version-history":[{"count":9,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12889\/revisions"}],"predecessor-version":[{"id":13018,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/12889\/revisions\/13018"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/12988"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=12889"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=12889"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=12889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}