{"id":13136,"date":"2025-04-07T03:06:01","date_gmt":"2025-04-07T03:06:01","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=13136"},"modified":"2025-04-07T04:47:06","modified_gmt":"2025-04-07T04:47:06","slug":"sertdepress","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/sertdepress\/","title":{"rendered":"\u300c\u3046\u3064\u75c5\u306b\u306a\u308a\u3084\u3059\u3044\u907a\u4f1d\u5b50\u300d\u306f\u3042\u308b\uff1f\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3068\u6c17\u5206\u306e\u95a2\u4fc2\u3092\u89e3\u8aac"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<p>\u3046\u3064\u75c5\u306f\u3001\u6301\u7d9a\u7684\u306a\u6291\u3046\u3064\u6c17\u5206\u3001\u8208\u5473\u3084\u559c\u3073\u306e\u55aa\u5931\u3001\u3055\u307e\u3056\u307e\u306a\u8eab\u4f53\u7684\u30fb\u7cbe\u795e\u7684\u75c7\u72b6\u3092\u7279\u5fb4\u3068\u3059\u308b\u3001\u4e00\u822c\u7684\u304b\u3064\u91cd\u7be4\u306a\u7cbe\u795e\u75be\u60a3\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u5b9f\u65bd\u3055\u308c\u305f\u5bb6\u65cf\u7814\u7a76\u3001\u53cc\u5b50\u7814\u7a76\u3001\u990a\u5b50\u7814\u7a76\u306b\u3088\u308a\u3001\u3046\u3064\u75c5\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u4e00\u8cab\u3057\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u539f\u56e0\u3068\u306a\u308b\u5177\u4f53\u7684\u306a\u907a\u4f1d\u5b50\u5909\u7570\u306f\u672a\u3060\u660e\u78ba\u306b\u306f\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"692\" height=\"360\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P31645-F1-1.png\" alt=\"Sodium-dependent serotonin transporter\" class=\"wp-image-13275\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P31645-F1-1.png 692w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P31645-F1-1-300x156.png 300w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5019\u88dc\u907a\u4f1d\u5b50\u3068\u3057\u3066\u9577\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\uff08SLC6A4\uff1asolute carrier family 6 member 4\uff09\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u6c17\u5206\u3084\u611f\u60c5\u3001\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u306e\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u300c\u30bb\u30ed\u30c8\u30cb\u30f3\uff08serotonin\uff09\u300d\u306e\u518d\u53d6\u308a\u8fbc\u307f\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff1aserotonin transporter\u3001\u7565\u79f0SERT\uff09\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002SERT\u306f\u795e\u7d4c\u9593\u9699\u304b\u3089\u30bb\u30ed\u30c8\u30cb\u30f3\u3092\u56de\u53ce\u3059\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u795e\u7d4c\u4f1d\u9054\u3092\u7d42\u4e86\u3055\u305b\u308b\u50cd\u304d\u3092\u6301\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306eSLC6A4\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\uff08\u8ee2\u5199\u6d3b\u6027\u3092\u5236\u5fa1\u3059\u308b\u9818\u57df\uff09\u306b\u306f\u30015-HTTLPR\uff08serotonin-transporter-linked polymorphic region\uff09\u3068\u547c\u3070\u308c\u308b\u591a\u578b\uff08polymorphism\uff09\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u633f\u5165\u307e\u305f\u306f\u6b20\u5931\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u9577\u9396\u578b\uff08l\u30a2\u30ec\u30eb\uff09\u3068\u77ed\u9396\u578b\uff08s\u30a2\u30ec\u30eb\uff09\u304b\u3089\u306a\u308a\u3001s\u30a2\u30ec\u30eb\u306f\u8ee2\u5199\u52b9\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u7d50\u679c\u3068\u3057\u3066SERT\u306e\u767a\u73fe\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"712\" height=\"396\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P31645-F1-2.png\" alt=\"5-HTTLPR\" class=\"wp-image-13289\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P31645-F1-2.png 712w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P31645-F1-2-300x167.png 300w\" sizes=\"(max-width: 712px) 100vw, 712px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u306es\u30a2\u30ec\u30eb\u3092\u6709\u3059\u308b\u500b\u4f53\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u85ac\uff08SSRI\uff1aselective serotonin reuptake inhibitors\uff09\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u53cd\u5fdc\u304c\u4e0d\u826f\u3067\u3042\u308b\u3068\u3044\u3046\u7814\u7a76\u5831\u544a\u304c\u8907\u6570\u5b58\u5728\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001s\/s\u30db\u30e2\u63a5\u5408\u4f53\uff08\u4e21\u89aa\u304b\u3089s\u30a2\u30ec\u30eb\u30921\u3064\u305a\u3064\u53d7\u3051\u7d99\u3050\u578b\uff09\u304c\u3046\u3064\u75c5\u306e\u30ea\u30b9\u30af\u3092\u72ec\u7acb\u3057\u3066\u9ad8\u3081\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u5831\u544a\u306b\u4e00\u8cab\u6027\u304c\u306a\u304f\u3001\u660e\u78ba\u306a\u7d50\u8ad6\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u4e00\u90e8\u306e\u7814\u7a76\u3067\u306f\u3001s\/s\u578b\u3068\u5358\u6975\u6027\u3046\u3064\u75c5\uff08unipolar depression\uff09\u3084\u53cc\u6975\u6027\u969c\u5bb3\uff08bipolar disorder\uff09\u3068\u306e\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4ed6\u306e\u7814\u7a76\u3067\u306f\u305d\u306e\u95a2\u9023\u304c\u5426\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u8fd1\u5e74\u3067\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u7684\u30b9\u30c8\u30ec\u30b9\u56e0\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\uff08gene-environment interaction\uff09\u304c\u3046\u3064\u75c5\u767a\u75c7\u306e\u9375\u3067\u3042\u308b\u3068\u3059\u308b\u8003\u3048\u3082\u6d6e\u4e0a\u3057\u3066\u304a\u308a\u3001\u6709\u540d\u306a\u7814\u7a76\uff08Caspi\u3089, 2003\uff09\u3067\u306f\u3001s\/s\u578b\u306e\u500b\u4f53\u304c\u5f37\u3044\u30b9\u30c8\u30ec\u30b9\u74b0\u5883\u4e0b\u3067\u3046\u3064\u75c5\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/3346307_s.jpg\" alt=\"\u3046\u3054\u3051\u3078\u3093\" class=\"wp-image-13296\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3346307_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/3346307_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3057\u304b\u3057\u306a\u304c\u3089\u3001s\/s\u578b\u304c\u74b0\u5883\u3068\u306f\u72ec\u7acb\u3057\u3066\u3046\u3064\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u3044\u307e\u3060\u8b70\u8ad6\u306e\u4f59\u5730\u304c\u3042\u308a\u3001\u7d71\u8a08\u7684\u306a\u691c\u51fa\u529b\uff08statistical power\uff09\u3084\u30b5\u30f3\u30d7\u30eb\u306e\u5747\u8cea\u6027\u306e\u554f\u984c\u304c\u904e\u53bb\u306e\u4e0d\u4e00\u81f4\u306e\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\uff08PREDICT-Gene\u7814\u7a76\uff09\u306f\u3001\u6b27\u5dde\u306e\u5927\u898f\u6a21\u75ab\u5b66\u8abf\u67fb\u300cPREDICT\u7814\u7a76\u300d\u306e\u4e00\u74b0\u3068\u3057\u3066\u3001\u30b9\u30da\u30a4\u30f3\u306e\u5730\u57df\u4f4f\u6c11\u3092\u5bfe\u8c61\u306b\u3001SLC6A4\u907a\u4f1d\u5b50\u306e5-HTTLPR\u591a\u578b\u3068ICD-10\u57fa\u6e96\u306b\u3088\u308b\u3046\u3064\u75c5\u3068\u306e\u95a2\u9023\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"737\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo17-MfZTTYHNZGUDOALARYAAAQVF.png\" alt=\"chromo17\" class=\"wp-image-13140\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo17-MfZTTYHNZGUDOALARYAAAQVF.png 737w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo17-MfZTTYHNZGUDOALARYAAAQVF-300x204.png 300w\" sizes=\"(max-width: 737px) 100vw, 737px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u7126\u70b9\u304c\u5f53\u3066\u3089\u308c\u3066\u3044\u308b\u306e\u306f\u3001SLC6A4\u907a\u4f1d\u5b50\u306b\u5b58\u5728\u3059\u308b\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u591a\u578b\u300c5-HTTLPR\u300d\u3067\u3059\u3002\u3053\u306e\u591a\u578b\u306f\u633f\u5165\uff08long\u30a2\u30ec\u30eb\uff1al\uff09\u307e\u305f\u306f\u6b20\u5931\uff08short\u30a2\u30ec\u30eb\uff1as\uff09\u306b\u3088\u308a\u5f62\u6210\u3055\u308c\u3001\u500b\u4f53\u306f\u6b21\u306e\u3044\u305a\u308c\u304b\u306e\u907a\u4f1d\u578b\uff08genotype\uff09\u3092\u6301\u3061\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>l\/l\u578b\uff08\u9577\u9396\u30db\u30e2\u63a5\u5408\u4f53\uff09<\/li>\n\n\n\n<li>l\/s\u578b\uff08\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\uff09<\/li>\n\n\n\n<li>s\/s\u578b\uff08\u77ed\u9396\u30db\u30e2\u63a5\u5408\u4f53\uff09<\/li>\n<\/ul>\n\n\n\n<p>s\u30a2\u30ec\u30eb\u306f\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u7d50\u679c\u3068\u3057\u3066SERT\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u518d\u53d6\u308a\u8fbc\u307f\u304c\u963b\u5bb3\u3055\u308c\u3001\u8133\u5185\u306e\u30bb\u30ed\u30c8\u30cb\u30f3\u6a5f\u80fd\u304c\u5909\u5316\u3057\u3084\u3059\u304f\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u6c17\u5206\u8abf\u7bc0\u969c\u5bb3\u3084\u3046\u3064\u75c5\u306e\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u8981\u56e0\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/SLC6A4-hgtIdeo_genome_377256_33a510-1024x25.png\" alt=\"SLC6A4\" class=\"wp-image-13147\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SLC6A4-hgtIdeo_genome_377256_33a510-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SLC6A4-hgtIdeo_genome_377256_33a510-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SLC6A4-hgtIdeo_genome_377256_33a510-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/SLC6A4-hgtIdeo_genome_377256_33a510.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u306a\u304a\u30015-HTTLPR\u306f\u53b3\u5bc6\u306b\u306fVNTR\uff08variable number tandem repeat\uff09\u578b\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3067\u3042\u308a\u3001SNP\uff08single nucleotide polymorphism\uff1a\u4e00\u5869\u57fa\u591a\u578b\uff09\u3068\u306f\u7570\u306a\u308b\u5206\u985e\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u6a5f\u80fd\u7684\u591a\u578b\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u540c\u69d8\u306e\u91cd\u8981\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3068\u53c2\u52a0\u8005<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2.jpg\" alt=\"\u5b9f\u9a13\u7ba1\" class=\"wp-image-12945\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u306f\u3001\u6b27\u5dde\u306e\u4e00\u6b21\u533b\u7642\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u300cPREDICT\u7814\u7a76\u300d\u306e\u30b9\u30da\u30a4\u30f3\u4eba\u30b5\u30f3\u30d7\u30eb\u3092\u5bfe\u8c61\u3068\u3057\u305f\u907a\u4f1d\u5b66\u7684\u95a2\u9023\u7814\u7a76\uff08PREDICT-Gene\u7814\u7a76\uff09\u3067\u3059\u30022003\u5e744\u6708\u304b\u30892004\u5e749\u6708\u306b\u304b\u3051\u3066\u3001\u30b9\u30da\u30a4\u30f3\u30fb\u30de\u30e9\u30ac\u306b\u3042\u308b9\u3064\u306e\u30d7\u30e9\u30a4\u30de\u30ea\u30fb\u30b1\u30a2\u30bb\u30f3\u30bf\u30fc\u3092\u8a2a\u308c\u305f18\u301c75\u6b73\u306e\u60a3\u8005\u304c\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>75\u6b73\u3092\u8d85\u3048\u308b\u9ad8\u9f62\u8005\u306f\u3001\u52a0\u9f62\u306b\u4f34\u3046\u8a8d\u77e5\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u305f\u3081\u9664\u5916\u3055\u308c\u307e\u3057\u305f\u3002\u52a0\u3048\u3066\u3001\u30b9\u30da\u30a4\u30f3\u8a9e\u304c\u7406\u89e3\u3067\u304d\u306a\u3044\u4eba\u3001\u5668\u8cea\u6027\u7cbe\u795e\u969c\u5bb3\u3084\u672b\u671f\u75be\u60a3\u3092\u6709\u3059\u308b\u4eba\u3082\u9664\u5916\u57fa\u6e96\u306b\u542b\u307e\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1026336_s.jpg\" alt=\"\u8a8d\u77e5\u75c7\" class=\"wp-image-13161\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1026336_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1026336_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u8a55\u4fa1\u65b9\u6cd5\u3068\u624b\u7d9a\u304d<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31994624_s.jpg\" alt=\"\u8a3a\u65ad\" class=\"wp-image-13168\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31994624_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31994624_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u53c2\u52a0\u8005\u306b\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\uff08Time-1\uff09\u30016\u304b\u6708\u5f8c\uff08Time-2\uff09\u300112\u304b\u6708\u5f8c\uff08Time-3\uff09\u306b\u9762\u63a5\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u304c\u3001\u672c\u7814\u7a76\u3067\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u70b9\u306e\u30c7\u30fc\u30bf\u306e\u307f\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3046\u3064\u75c5\u306e\u8a3a\u65ad\u306b\u306f\u3001WHO\u304c\u958b\u767a\u3057\u305f\u6a19\u6e96\u5316\u9762\u63a5\u30c4\u30fc\u30eb\u300cCIDI\uff08Composite International Diagnostic Interview\uff09\u300d\u306e\u3046\u3064\u75c5\u30e2\u30b8\u30e5\u30fc\u30eb\u3092\u7528\u3044\u3001ICD-10\u306e\u8a3a\u65ad\u57fa\u6e96\u306b\u57fa\u3065\u3044\u3066\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u9762\u63a5\u306f\u533b\u5b66\u7684\u8a13\u7df4\u3092\u53d7\u3051\u305f\u7814\u7a76\u8005\u3067\u306f\u306a\u304f\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u53d7\u3051\u305f\u9762\u63a5\u8005\u304c\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31518558_s.jpg\" alt=\"\u3046\u3064\u75c5\" class=\"wp-image-13175\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31518558_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31518558_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5168\u822c\u6027\u4e0d\u5b89\u969c\u5bb3\uff08GAD\uff1ageneralized anxiety disorder\uff09\u306e\u8a55\u4fa1\u306b\u306f\u3001\u30b9\u30da\u30a4\u30f3\u8a9e\u7248PHQ\uff08Patient Health Questionnaire\uff09\u306e\u4e0d\u5b89\u30e2\u30b8\u30e5\u30fc\u30eb\u304c\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306fDSM-IV\u306b\u6e96\u62e0\u3057\u305f\u69cb\u9020\u5316\u8cea\u554f\u7968\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u691c\u67fb<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/23463921_s.jpg\" alt=\"\u8840\u6db2\" class=\"wp-image-12832\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23463921_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/23463921_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Time-3\u6642\u70b9\u3067\u518d\u5ea6\u540c\u610f\u3092\u53d6\u5f97\u3057\u3001\u53c2\u52a0\u8005\u304b\u3089\u8840\u6db2\uff0810cc\uff09\u307e\u305f\u306f\u53e3\u8154\u7c98\u819c\u30b9\u30ef\u30d6\u306b\u3088\u308b\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6\u3057\u307e\u3057\u305f\u3002DNA\u306f\u6a19\u6e96\u7684\u306a\u624b\u6cd5\u306b\u3088\u308a\u62bd\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>5-HTTLPR\u306e\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\u306f\u3001PCR\uff08\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9023\u9396\u53cd\u5fdc\uff09\u6cd5\u306b\u3088\u308a\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u7279\u5b9a\u306eDNA\u9818\u57df\u3092\u5897\u5e45\u3059\u308b\u5206\u5b50\u751f\u7269\u5b66\u7684\u624b\u6cd5\u3067\u3059\u3002\u5f97\u3089\u308c\u305fDNA\u65ad\u7247\u306f2%\u30a2\u30ac\u30ed\u30fc\u30b9\u30b2\u30eb\u96fb\u6c17\u6cf3\u52d5\u3068\u30a8\u30c1\u30b8\u30a6\u30e0\u30d6\u30ed\u30de\u30a4\u30c9\u67d3\u8272\u306b\u3088\u308a\u8b58\u5225\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"448\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/928605_s.jpg\" alt=\"\u5168\u529b\u3067\u96fb\u6c17\u6cf3\u52d5\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\" class=\"wp-image-13182\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/928605_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/928605_s-300x210.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u54c1\u8cea\u7ba1\u7406<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/262188_s.jpg\" alt=\"\u4e16\u754c\u306e\u305f\u3081\u306b\" class=\"wp-image-13189\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/262188_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/262188_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u30c7\u30fc\u30bf\u306e\u6b63\u78ba\u6027\u3068\u4fe1\u983c\u6027\u3092\u62c5\u4fdd\u3059\u308b\u305f\u3081\u3001\u3059\u3079\u3066\u306e\u9762\u63a5\u8005\u306b\u306fCIDI\u304a\u3088\u3073\u30ea\u30b9\u30af\u56e0\u5b50\u8cea\u554f\u7968\u306e\u8a13\u7df4\u304c\u6a19\u6e96\u5316\u3055\u308c\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u8cea\u554f\u7968\u306e\u7ffb\u8a33\u306f\u3001\u82f1\u8a9e\u304b\u3089\u30b9\u30da\u30a4\u30f3\u8a9e\u3078\u306e\u7ffb\u8a33\u5f8c\u3001\u9006\u7ffb\u8a33\u3092\u884c\u3044\u3001\u30ed\u30f3\u30c9\u30f3\u306e\u7d71\u62ec\u30bb\u30f3\u30bf\u30fc\u3067\u7167\u5408\u3055\u308c\u307e\u3057\u305f\u3002\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u306e10%\u306f\u4e8c\u91cd\u5165\u529b\u3055\u308c\u3001\u5165\u529b\u30df\u30b9\u306f\u308f\u305a\u304b0.13%\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d71\u8a08\u89e3\u6790<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-1.jpg\" alt=\"\u30c7\u30fc\u30bf\u89e3\u6790\" class=\"wp-image-12938\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u7d71\u8a08\u89e3\u6790\u306b\u306fSPSS ver.13.0\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305a\u3001\u5909\u6570\u306e\u5206\u5e03\u3092\u63a2\u7d22\u7684\u306b\u5206\u6790\u3057\u3001\u7d9a\u3044\u3066\u5358\u5909\u91cf\u89e3\u6790\u3068\u591a\u5909\u91cf\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u5206\u6790\u306b\u3088\u308a\u3001s\/s\u578b\u3068\u3046\u3064\u75c5\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u8abf\u6574\u30e2\u30c7\u30eb\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30e2\u30c7\u30ebA\uff1a\u5e74\u9f62\u30fb\u6027\u5225\u3067\u8abf\u6574<\/li>\n\n\n\n<li>\u30e2\u30c7\u30ebB\uff1a\u30e2\u30c7\u30ebA + \u5bb6\u65cf\u6b74\u3067\u8abf\u6574<\/li>\n\n\n\n<li>\u30e2\u30c7\u30ebC\uff1a\u30e2\u30c7\u30ebB + GAD\u4f75\u5b58\u3067\u8abf\u6574<\/li>\n<\/ul>\n\n\n\n<p>\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff1aodds ratio\uff09\u304a\u3088\u307395%\u4fe1\u983c\u533a\u9593\uff0895% CI\uff09\u3092\u7b97\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u30b5\u30f3\u30d7\u30eb\u306e\u7279\u5fb4<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31518350_s-1.jpg\" alt=\"\u3046\u3064\u75c5\" class=\"wp-image-13196\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31518350_s-1.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31518350_s-1-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5168\u4f53\u3067922\u540d\u304cTime-3\u307e\u3067\u8ffd\u8de1\u3055\u308c\u3001\u305d\u306e\u3046\u3061737\u540d\uff0880%\uff09\u304c\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u540c\u610f\u3092\u63d0\u4f9b\u3057\u3001\u8840\u6db2\u307e\u305f\u306f\u553e\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u63d0\u4f9b\u3057\u307e\u3057\u305f\u3002\u5973\u6027\u304c71.8%\uff08529\u540d\uff09\u3001\u7537\u6027\u304c28.2%\uff08208\u540d\uff09\u3067\u3001\u5e73\u5747\u5e74\u9f62\u306f49\u6b73\uff08\u6a19\u6e96\u504f\u5dee15.2\uff09\u3067\u3057\u305f\u3002\u6559\u80b2\u6b74\u306f\u3001\u521d\u7b49\u6559\u80b2\u4fee\u4e86\u304c60.1%\u3001\u4e2d\u7b49\u6559\u80b2\u4ee5\u4e0a\u304c36.6%\u3092\u5360\u3081\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u5bfe\u8c61\u8005\u306e36.6%\uff08270\u540d\uff09\u306f\u3001\u4e00\u89aa\u7b49\u306e\u5bb6\u65cf\u306b\u7cbe\u795e\u7684\u554f\u984c\u306e\u65e2\u5f80\u6b74\u304c\u3042\u308b\u3068\u5831\u544a\u3057\u307e\u3057\u305f\u300217%\uff08127\u540d\uff09\u306f\u3001PHQ\u306b\u3088\u308aGAD\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31929577_s.jpg\" alt=\"\u982d\u3092\u62b1\u3048\u3066\" class=\"wp-image-13203\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31929577_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31929577_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u578b\u304a\u3088\u3073\u30a2\u30ec\u30eb\u983b\u5ea6<\/h3>\n\n\n\n<p>\u53c2\u52a0\u8005737\u540d\u306e\u907a\u4f1d\u5b50\u578b\u306e\u5185\u8a33\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>l\/l\u578b\uff1a192\u540d\uff0826.1%\uff09<\/li>\n\n\n\n<li>l\/s\u578b\uff1a367\u540d\uff0849.9%\uff09<\/li>\n\n\n\n<li>s\/s\u578b\uff1a178\u540d\uff0824.1%\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u30a2\u30ec\u30eb\u983b\u5ea6\u306f\u3001l\u30a2\u30ec\u30eb\u304c50.95%\u3001s\u30a2\u30ec\u30eb\u304c49.05%\u3067\u3057\u305f\u3002\u907a\u4f1d\u5b50\u578b\u5206\u5e03\u306f\u3001\u30cf\u30fc\u30c7\u30a3\u30fb\u30ef\u30a4\u30f3\u30d9\u30eb\u30b0\u5e73\u8861\uff08Hardy\u2013Weinberg equilibrium\uff09\u3092\u6e80\u305f\u3057\u3066\u304a\u308a\u3001\u6bcd\u96c6\u56e3\u306e\u4ee3\u8868\u6027\u304c\u4fdd\u305f\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"366\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31914878_s.jpg\" alt=\"\u5f15\u304d\u88c2\u3051\u3089\u308c\u3066\u3044\u308b\u81ea\u5206\u306e\u5fc3\" class=\"wp-image-13215\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31914878_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31914878_s-300x172.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u3046\u3064\u75c5\u306e\u6709\u75c5\u7387<\/h3>\n\n\n\n<p>6\u304b\u6708\u9593\u306eICD-10\u3046\u3064\u75c5\u30a8\u30d4\u30bd\u30fc\u30c9\uff08\u8efd\u5ea6\u301c\u91cd\u5ea6\uff09\u306e\u6709\u75c5\u7387\u306f35.4%\uff08262\u540d\uff09\u3001\u91cd\u5ea6\u3046\u3064\u75c5\u30a8\u30d4\u30bd\u30fc\u30c9\u306e\u6709\u75c5\u7387\u306f24.8%\uff08183\u540d\uff09\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31578783_s.jpg\" alt=\"\u304c\u3063\u304b\u308a\" class=\"wp-image-13222\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31578783_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31578783_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u5358\u5909\u91cf\u89e3\u6790\u306b\u3088\u308b\u95a2\u9023<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"424\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/225203_s.jpg\" alt=\"\u6a2a\u305f\u3048\u308b\" class=\"wp-image-13238\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/225203_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/225203_s-300x199.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>s\u30a2\u30ec\u30eb\u306f\u3001\u3046\u3064\u75c5\u304a\u3088\u3073\u91cd\u5ea6\u3046\u3064\u75c5\u306e\u3044\u305a\u308c\u306b\u304a\u3044\u3066\u3082\u6709\u610f\u306b\u9ad8\u983b\u5ea6\u3067\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ICD-10\u3046\u3064\u75c5\u30a8\u30d4\u30bd\u30fc\u30c9\uff1aOR = 1.24\uff0895% CI: 1.0\u20131.54\uff09\u3001P = 0.050<\/li>\n\n\n\n<li>\u91cd\u5ea6\u3046\u3064\u75c5\u30a8\u30d4\u30bd\u30fc\u30c9\uff1aOR = 1.31\uff0895% CI: 1.02\u20131.68\uff09\u3001P = 0.031<\/li>\n<\/ul>\n\n\n\n<p>\u3055\u3089\u306b\u3001s\u30a2\u30ec\u30eb\u306e\u6570\u304c\u5897\u3048\u308b\u307b\u3069\u3046\u3064\u75c5\u306e\u91cd\u75c7\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3068\u3044\u3046\u7dda\u5f62\u7684\u306a\u95a2\u9023\u304c\u6709\u610f\u306b\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\uff08\u30ab\u30a4\u4e8c\u4e57\u691c\u5b9a \u03c7\u00b2 = 6.13, P = 0.013\uff09\u3002\u3053\u308c\u306f\u3001\u907a\u4f1d\u7684\u300c\u7528\u91cf\u4f9d\u5b58\u6027\uff08dose-dependent relationship\uff09\u300d\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"426\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4457940_s.jpg\" alt=\"\u3057\u3093\u3069\u3044\" class=\"wp-image-13246\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4457940_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4457940_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3046\u3064\u75c5\u3068\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u305f\u4ed6\u306e\u56e0\u5b50\u306b\u306f\u4ee5\u4e0b\u304c\u3042\u308a\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5973\u6027\u3067\u3042\u308b\u3053\u3068\uff08OR \u7d042.4\uff09<\/li>\n\n\n\n<li>\u82e5\u5e74\u3067\u3042\u308b\u3053\u3068<\/li>\n\n\n\n<li>\u4e00\u89aa\u7b49\u306e\u5bb6\u65cf\u306b\u7cbe\u795e\u75be\u60a3\u306e\u65e2\u5f80\u304c\u3042\u308b\u3053\u3068\uff08OR = 1.92\u301c2.09\u3001\u3044\u305a\u308c\u3082P &lt; 0.001\uff09<\/li>\n\n\n\n<li>GAD\u3092\u4f75\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\uff08\u3046\u3064\u75c5\uff1aOR = 9.5\u3001\u91cd\u5ea6\u3046\u3064\u75c5\uff1aOR = 17.9\u3001\u3044\u305a\u308c\u3082P &lt; 0.0001\uff09<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31673563_s.jpg\" alt=\"\u819d\u3092\u62b1\u3048\" class=\"wp-image-13253\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31673563_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31673563_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001s\/s\u578b\u3068GAD\u3068\u306e\u9593\u306b\u306f\u6709\u610f\u306a\u95a2\u9023\u306f\u898b\u3089\u308c\u305a\uff08\u03c7\u00b2 = 1.6, P = 0.19\uff09\u3001s\/s\u578b\u306e\u3046\u3064\u75c5\u30ea\u30b9\u30af\u5897\u52a0\u52b9\u679c\u304c\u4e0d\u5b89\u969c\u5bb3\u3068\u306f\u72ec\u7acb\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u591a\u5909\u91cf\u30e2\u30c7\u30eb\u306b\u3088\u308b\u72ec\u7acb\u3057\u305f\u95a2\u9023\u6027\u306e\u691c\u8a0e<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/24398132_s.jpg\" alt=\"\u900f\u660e\u306b\u306a\u308b\" class=\"wp-image-13260\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24398132_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/24398132_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5e74\u9f62\u30fb\u6027\u5225\u30fb\u5bb6\u65cf\u6b74\u30fbGAD\u3092\u6bb5\u968e\u7684\u306b\u8abf\u6574\u3057\u305f3\u3064\u306e\u591a\u5909\u91cf\u30e2\u30c7\u30eb\u3067\u3082\u3001s\/s\u578b\u3068\u3046\u3064\u75c5\u3068\u306e\u95a2\u9023\u306f\u4e00\u8cab\u3057\u3066\u6709\u610f\u3067\u3042\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30aa\u30c3\u30ba\u6bd4\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<p><strong>ICD-10\u3046\u3064\u75c5\u30a8\u30d4\u30bd\u30fc\u30c9<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30e2\u30c7\u30ebA\uff1aOR = 1.53\uff0895% CI: 1.07\u20132.2\uff09\u3001P = 0.018<\/li>\n\n\n\n<li>\u30e2\u30c7\u30ebB\uff1aOR = 1.53\uff0895% CI: 1.06\u20132.2\uff09\u3001P = 0.020<\/li>\n\n\n\n<li>\u30e2\u30c7\u30ebC\uff1aOR = 1.50\uff0895% CI: 1.009\u20132.24\uff09\u3001P = 0.045<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/22138310_s.jpg\" alt=\"\u6ce3\u304f\" class=\"wp-image-13267\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22138310_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22138310_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>ICD-10\u91cd\u5ea6\u3046\u3064\u75c5\u30a8\u30d4\u30bd\u30fc\u30c9<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30e2\u30c7\u30ebA\uff1aOR = 1.58\uff0895% CI: 1.07\u20132.3\uff09\u3001P = 0.022<\/li>\n\n\n\n<li>\u30e2\u30c7\u30ebB\uff1aOR = 1.65\uff0895% CI: 1.1\u20132.5\uff09\u3001P = 0.016<\/li>\n\n\n\n<li>\u30e2\u30c7\u30ebC\uff1aOR = 1.79\uff0895% CI: 1.1\u20132.8\uff09\u3001P = 0.016<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001SLC6A4\u907a\u4f1d\u5b50\u306e5-HTTLPR\u591a\u578b\u306b\u304a\u3044\u3066s\/s\u578b\u3092\u6709\u3059\u308b\u4eba\u306f\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u4e00\u89aa\u7b49\u306e\u5bb6\u65cf\u6b74\u3001\u4f75\u5b58\u3059\u308b\u4e0d\u5b89\u969c\u5bb3\uff08GAD\uff09\u306a\u3069\u306e\u5f71\u97ff\u3068\u306f\u72ec\u7acb\u3057\u3066\u3001\u3046\u3064\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u95a2\u9023\u6027\u306f\u3046\u3064\u75c5\u306e\u91cd\u75c7\u5ea6\u304c\u9ad8\u307e\u308b\u307b\u3069\u5f37\u307e\u308b\u50be\u5411\u3092\u793a\u3057\u3001\u907a\u4f1d\u7684\u306a\u7528\u91cf\u4f9d\u5b58\u52b9\u679c\u306e\u5b58\u5728\u304c\u652f\u6301\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"428\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31532713_s.jpg\" alt=\"\u6697\u3044\u7a7a\" class=\"wp-image-13303\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31532713_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31532713_s-300x201.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u904e\u53bb\u306e\u7814\u7a76\u3067\u7d50\u679c\u304c\u4e00\u8cab\u3057\u306a\u304b\u3063\u305f\u8981\u56e0\u306b\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u4e0d\u8db3\u3001\u5bfe\u8c61\u96c6\u56e3\u306e\u7570\u8cea\u6027\u3001\u4ea4\u7d61\u56e0\u5b50\u306e\u672a\u8abf\u6574\u306a\u3069\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u5927\u898f\u6a21\u304b\u3064\u4ee3\u8868\u6027\u306e\u3042\u308b\u30b5\u30f3\u30d7\u30eb\u3001\u53b3\u5bc6\u306a\u7d71\u8a08\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u3053\u3068\u306b\u3088\u308a\u3001\u305d\u3046\u3057\u305f\u554f\u984c\u3092\u514b\u670d\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>GAD\u3068s\/s\u578b\u306b\u95a2\u9023\u304c\u306a\u304b\u3063\u305f\u70b9\u3082\u91cd\u8981\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001s\/s\u578b\u306e\u30ea\u30b9\u30af\u52b9\u679c\u304c\u3046\u3064\u75c5\u306b\u7279\u7570\u7684\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31600194_s.jpg\" alt=\"\u96f2\u3092\u901a\u308b\u5149\" class=\"wp-image-13310\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31600194_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31600194_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5206\u5b50\u751f\u7269\u5b66\u7684\u306a\u8996\u70b9\u3067\u306f\u3001s\u30a2\u30ec\u30eb\u304cSLC6A4\u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u306e\u52b9\u7387\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u6c17\u5206\u8abf\u7bc0\u6a5f\u69cb\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001fMRI\uff08\u6a5f\u80fd\u7684MRI\uff09\u3092\u7528\u3044\u305f\u8133\u753b\u50cf\u7814\u7a76\u3067\u306f\u3001s\/s\u578b\u3092\u6301\u3064\u500b\u4f53\u306e\u6241\u6843\u4f53\uff08amygdala\uff09\u304c\u6050\u6016\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u904e\u654f\u306b\u53cd\u5fdc\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u3046\u3064\u75c5\u611f\u53d7\u6027\u306e\u795e\u7d4c\u751f\u7269\u5b66\u7684\u57fa\u76e4\u306e\u4e00\u90e8\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4038814_s.jpg\" alt=\"\u3042\u306a\u305f\u306f\u4e00\u4eba\u3058\u3083\u306a\u3044\" class=\"wp-image-13317\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4038814_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4038814_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\uff08PREDICT-Gene\u7814\u7a76\uff09\u306f\u3001SLC6A4\u907a\u4f1d\u5b50\u306b\u304a\u3051\u308b5-HTTLPR\u591a\u578b\u306es\/s\u578b\u304c\u3001\u4e00\u6b21\u533b\u7642\u3092\u53d7\u8a3a\u3059\u308b\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3044\u3066\u3046\u3064\u75c5\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u3001\u304b\u3064\u72ec\u7acb\u3057\u3066\u9ad8\u3081\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u95a2\u9023\u6027\u306f\u3001\u3046\u3064\u75c5\u306e\u91cd\u75c7\u5ea6\u304c\u9ad8\u307e\u308b\u307b\u3069\u5f37\u307e\u308b\u50be\u5411\u3092\u793a\u3057\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306e\u907a\u4f1d\u7684\u591a\u578b\u304c\u3046\u3064\u75c5\u611f\u53d7\u6027\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u5f37\u304f\u652f\u6301\u3057\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>\u3046\u3064\u75c5, \u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc, SLC6A4, 5-HTTLPR, \u4e00\u5869\u57fa\u591a\u578b, \u907a\u4f1d\u5b50\u591a\u578b, \u5168\u822c\u6027\u4e0d\u5b89\u969c\u5bb3, \u30d7\u30e9\u30a4\u30de\u30ea\u30fb\u30b1\u30a2, \u30ea\u30b9\u30af\u56e0\u5b50, depression, serotonin transporter, SLC6A4, 5-HTTLPR, single nucleotide polymorphism, genetic polymorphism, generalized anxiety disorder, primary care, risk factor<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32231934_s.jpg\" alt=\"\u4fe1\u983c\u3067\u304d\u308b\u4eba\u304c\u5c45\u308c\u3070\u5e78\u3044\" class=\"wp-image-13324\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32231934_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32231934_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1002\/ajmg.b.30455\">Cervilla, J. A., Rivera, M., Molina, E., Torres-Gonz\u00e1lez, F., Bell\u00f3n, J. A., Moreno, B., de Dios Luna, J., Lorente, J. A., de Diego-Otero, Y., King, M., Nazareth, I., Guti\u00e9rrez, B., &amp; PREDICT Study Core Group (2006). The 5-HTTLPR s\/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of primary care attendees: the PREDICT-gene study.\u00a0<em>American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics<\/em>,\u00a0<em>141B<\/em>(8), 912\u2013917. https:\/\/doi.org\/10.1002\/ajmg.b.30455<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). 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