{"id":13332,"date":"2025-04-07T03:55:32","date_gmt":"2025-04-07T03:55:32","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=13332"},"modified":"2025-04-07T04:46:40","modified_gmt":"2025-04-07T04:46:40","slug":"crohn","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/crohn\/","title":{"rendered":"\u65b0\u305f\u306b\u5224\u660e\u3057\u305f\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u30ea\u30b9\u30af\u907a\u4f1d\u5b50\u300cNOD2\u5909\u7570\u300d\u3068\u306f\uff1f\u2015\u6700\u65b0\u7814\u7a76\u304c\u793a\u3059\u767a\u75c7\u3068\u306e\u95a2\u4fc2\u3068\u91cd\u75c7\u5316\u30ea\u30b9\u30af"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff5cBackground<\/h2>\n\n\n\n<p>\u30af\u30ed\u30fc\u30f3\u75c5\uff08Crohn&#8217;s disease\uff1aCD\uff09\u304a\u3088\u3073\u6f70\u760d\u6027\u5927\u8178\u708e\uff08Ulcerative colitis\uff1aUC\uff09\u306f\u3001\u8178\u7ba1\u306b\u6162\u6027\u7684\u306a\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u708e\u75c7\u6027\u8178\u75be\u60a3\uff08Inflammatory bowel disease\uff1aIBD\uff09\u306e2\u5927\u75be\u60a3\u3067\u3059\u3002CD\u306f\u6d88\u5316\u7ba1\u306e\u3069\u306e\u90e8\u4f4d\u306b\u3082\u767a\u75c7\u3057\u5f97\u3066\u3001\u8178\u58c1\u306e\u6df1\u5c64\u306b\u307e\u3067\u53ca\u3076\u708e\u75c7\u3092\u7279\u5fb4\u3068\u3059\u308b\u4e00\u65b9\u3001UC\u306f\u901a\u5e38\u3001\u5927\u8178\u306b\u9650\u5c40\u3057\u3001\u7c98\u819c\u5c64\u306b\u9650\u5c40\u3057\u305f\u708e\u75c7\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/26123006_s.jpg\" alt=\"\u708e\u75c7\u6027\u8178\u75be\u60a3\" class=\"wp-image-13369\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/26123006_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/26123006_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>IBD\u306e\u767a\u75c7\u306b\u306f\u3001\u74b0\u5883\u56e0\u5b50\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u7570\u5e38\u3001\u8178\u5185\u7d30\u83cc\u53e2\u3001\u305d\u3057\u3066\u907a\u4f1d\u7684\u7d20\u56e0\u304c\u8907\u96d1\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002IBD\u306b\u304a\u3051\u308b\u907a\u4f1d\u7684\u7814\u7a76\u306e\u4e2d\u3067\u3082\u7279\u306b\u91cd\u8981\u306a\u767a\u898b\u306e\u4e00\u3064\u304c\u30012001\u5e74\u306b\u5831\u544a\u3055\u308c\u305fNOD2\uff08Nucleotide-binding oligomerization domain-containing protein 2\u3001\u5225\u540dCARD15\uff09\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3067\u3059\u3002NOD2\u306f\u81ea\u7136\u514d\u75ab\u306b\u95a2\u4e0e\u3059\u308b\u7d30\u80de\u8cea\u5185\u53d7\u5bb9\u4f53\u3067\u3042\u308a\u3001\u7d30\u83cc\u306e\u7d30\u80de\u58c1\u6210\u5206\u3067\u3042\u308b\u30e0\u30e9\u30df\u30eb\u30b8\u30da\u30d7\u30c1\u30c9\uff08Muramyl dipeptide\uff1aMDP\uff09\u3092\u8a8d\u8b58\u3057\u3066\u3001NF-\u03baB\uff08Nuclear factor kappa-light-chain-enhancer of activated B cells\uff09\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u3053\u306e\u7d4c\u8def\u306f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306e\u7523\u751f\u3092\u4fc3\u9032\u3057\u3001\u8178\u7ba1\u7c98\u819c\u306e\u514d\u75ab\u9632\u5fa1\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"659\" height=\"609\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HC29-F1-1.png\" alt=\"Nucleotide-binding oligomerization domain-containing protein 2\" class=\"wp-image-13376\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HC29-F1-1.png 659w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HC29-F1-1-300x277.png 300w\" sizes=\"(max-width: 659px) 100vw, 659px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>NOD2\u306e\u6a5f\u80fd\u7570\u5e38\u306f\u3001\u7d30\u83cc\u8a8d\u8b58\u306e\u969c\u5bb3\u3084\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306e\u767a\u73fe\u4f4e\u4e0b\u3092\u901a\u3058\u3066\u3001\u8178\u7ba1\u306e\u904e\u5270\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u6162\u6027\u7684\u306a\u708e\u75c7\u3092\u3082\u305f\u3089\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u308b3\u3064\u306e\u4ee3\u8868\u7684\u306aNOD2\u5909\u7570\uff08p.Arg702Trp\uff3brs2066844\uff3d\u3001p.Gly908Arg\uff3brs2066847\uff3d\u3001p.Leu1007fsX1008\uff3brs2066847\uff3d\uff09\u306f\u3001\u7279\u306b\u7d42\u672b\u56de\u8178\uff08terminal ileum\uff09\u75c5\u5909\u3084\u8178\u7ba1\u72ed\u7a84\uff08stricturing\uff09\u3001\u763b\u5b54\u5f62\u6210\uff08penetrating\uff09\u306a\u3069\u306e\u8907\u96d1\u306a\u75c5\u578b\u3068\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"705\" height=\"648\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HC29-F1-3.png\" alt=\"Nucleotide-binding oligomerization domain-containing protein 2\" class=\"wp-image-13397\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HC29-F1-3.png 705w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-Q9HC29-F1-3-300x276.png 300w\" sizes=\"(max-width: 705px) 100vw, 705px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3057\u304b\u3057\u306a\u304c\u3089\u3001rs2066843\u304a\u3088\u3073rs2076756\u3068\u3044\u3063\u305f\u305d\u306e\u4ed6\u306e\u4e00\u5869\u57fa\u591a\u578b\uff08Single nucleotide polymorphism\uff1aSNP\uff09\u306e\u75c5\u56e0\u7684\u610f\u7fa9\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u308c\u307e\u3067\u5341\u5206\u306b\u691c\u8a0e\u3055\u308c\u3066\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u65b0\u898fSNP\u304cIBD\u306e\u767a\u75c7\u611f\u53d7\u6027\u304a\u3088\u3073\u75be\u60a3\u8868\u73fe\u578b\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff5cAssociated genes &amp; SNPs<\/h2>\n\n\n\n<p>NOD2\u907a\u4f1d\u5b50\u306f\u67d3\u8272\u4f5316q12\u306eIBD1\u907a\u4f1d\u5b50\u5ea7\u306b\u4f4d\u7f6e\u3057\u300111\u500b\u306e\u69cb\u6210\u7684\u30a8\u30af\u30bd\u30f3\u3068\u3001\u9078\u629e\u7684\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u3088\u3063\u3066\u767a\u73fe\u3055\u308c\u308b\u7b2c12\u30a8\u30af\u30bd\u30f3\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u30d1\u30bf\u30fc\u30f3\u8a8d\u8b58\u53d7\u5bb9\u4f53\uff08Pattern recognition receptor\uff1aPRR\uff09\u3068\u3057\u3066\u3001\u7d30\u80de\u5185\u306b\u4fb5\u5165\u3057\u305f\u7d30\u83cc\u7531\u6765\u306e\u5206\u5b50\u3092\u611f\u77e5\u3057\u3001\u708e\u75c7\u6027\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u9054\u3059\u308b\u6a5f\u80fd\u3092\u62c5\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs2066843-hgtIdeo_genome_14feaa_3478d0-1024x25.png\" alt=\"rs2066843\" class=\"wp-image-13383\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2066843-hgtIdeo_genome_14feaa_3478d0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2066843-hgtIdeo_genome_14feaa_3478d0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2066843-hgtIdeo_genome_14feaa_3478d0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2066843-hgtIdeo_genome_14feaa_3478d0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs2076756-hgtIdeo_genome_1532a7_347b00-1024x25.png\" alt=\"rs2076756\" class=\"wp-image-13390\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2076756-hgtIdeo_genome_1532a7_347b00-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2076756-hgtIdeo_genome_1532a7_347b00-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2076756-hgtIdeo_genome_1532a7_347b00-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2076756-hgtIdeo_genome_1532a7_347b00.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u3067\u89e3\u6790\u3055\u308c\u305fSNP\u3067\u3042\u308brs2066843\u304a\u3088\u3073rs2076756\u306f\u3001\u3053\u308c\u307e\u3067\u8a73\u7d30\u306a\u75ab\u5b66\u7684\u691c\u8a0e\u304c\u884c\u308f\u308c\u3066\u3053\u306a\u304b\u3063\u305fNOD2\u5185\u306e\u5171\u901a\u5909\u7570\u3067\u3042\u308a\u3001\u65e2\u77e5\u306e\u5909\u7570\u3068\u306e\u6bd4\u8f03\u3082\u542b\u3081\u3066\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"751\" height=\"500\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/chromo16-MfZSYEbXLNYQECKAdMAAACKD.png\" alt=\"chromo16\" class=\"wp-image-13029\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo16-MfZSYEbXLNYQECKAdMAAACKD.png 751w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/chromo16-MfZSYEbXLNYQECKAdMAAACKD-300x200.png 300w\" sizes=\"(max-width: 751px) 100vw, 751px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u672c\u7814\u7a76\u3067\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08Autophagy\uff09\u306b\u95a2\u4e0e\u3059\u308bATG16L1\u907a\u4f1d\u5b50\u306eCD\u95a2\u9023SNP\u3067\u3042\u308brs2241880\uff08p.Thr300Ala\uff09\u3068\u306e\u30a8\u30d4\u30b9\u30bf\u30b7\u30b9\uff08epistasis\uff1a\u907a\u4f1d\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\uff09\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3082\u89e3\u6790\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002NOD2\u3068ATG16L1\u306f\u3001\u7d30\u80de\u5185\u75c5\u539f\u4f53\u306e\u6392\u9664\u904e\u7a0b\u3067\u6a5f\u80fd\u7684\u306b\u9023\u643a\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u76f8\u4e92\u4f5c\u7528\u304cCD\u306e\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/h2>\n\n\n\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001rs2066843\u304a\u3088\u3073rs2076756\u304c\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u306b\u5bfe\u3059\u308b\u65b0\u898f\u304b\u3064\u5171\u901a\u3059\u308b\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u5909\u7570\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306eSNP\u306f\u6f70\u760d\u6027\u5927\u8178\u708e\u3068\u306f\u6709\u610f\u306a\u95a2\u9023\u3092\u793a\u3055\u305a\u3001CD\u3068UC\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306e\u9055\u3044\u3092\u6539\u3081\u3066\u88cf\u4ed8\u3051\u308b\u7d50\u679c\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/27918348_s.jpg\" alt=\"\u30ac\u30a1\u30c3\" class=\"wp-image-13404\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/27918348_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/27918348_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u75be\u60a3\u611f\u53d7\u6027\u306b\u52a0\u3048\u3066\u3001\u3053\u308c\u3089\u306eSNP\u304c\u65e9\u671f\u767a\u75c7\u3001\u763b\u5b54\u5f62\u6210\u3092\u4f34\u3046\u6d78\u6f64\u578b\u8868\u73fe\u578b\u3001\u5916\u79d1\u7684\u624b\u8853\u306e\u5fc5\u8981\u6027\u306a\u3069\u3001CD\u306e\u91cd\u75c7\u75c5\u578b\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u591a\u5909\u91cf\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u89e3\u6790\u306e\u7d50\u679c\u3067\u306f\u3001\u3053\u308c\u3089\u306eSNP\u3088\u308a\u3082\u3001\u75c5\u5909\u90e8\u4f4d\uff08\u4f8b\uff1a\u56de\u8178\u578b vs \u7d50\u8178\u578b\uff09\u3084\u75c5\u578b\u5206\u985e\uff08\u72ed\u7a84\u578b\u30fb\u6d78\u6f64\u578b\u306a\u3069\uff09\u306e\u65b9\u304c\u3001\u624b\u8853\u306e\u5fc5\u8981\u6027\u306b\u5bfe\u3059\u308b\u3088\u308a\u5f37\u529b\u306a\u72ec\u7acb\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/28538196_s.jpg\" alt=\"\u30cc\u30a9\u30a9\u30a9\" class=\"wp-image-13411\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/28538196_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/28538196_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u307e\u305f\u3001rs2066843\u304a\u3088\u3073rs2076756\u306e\u75c5\u578b\u4fee\u98fe\u52b9\u679c\u306f\u3001\u5f93\u6765\u306eNOD2\u5909\u7570\uff08rs2066844, rs2066847\uff09\u3092\u6709\u3059\u308b\u304b\u5426\u304b\u306b\u304b\u304b\u308f\u3089\u305a\u4e00\u8cab\u3057\u3066\u304a\u308a\u3001\u72ec\u7acb\u3057\u305f\u4fee\u98fe\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u30a8\u30d4\u30b9\u30bf\u30b7\u30b9\u89e3\u6790\u3067\u306f\u3001NOD2\u5909\u7570\u3068ATG16L1\uff08rs2241880\uff09\u5909\u7570\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u76f8\u4e92\u4f5c\u7528\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u4e21\u8005\u304c\u6a5f\u80fd\u7684\u306b\u306f\u95a2\u9023\u3057\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u907a\u4f1d\u7684\u306b\u306f\u72ec\u7acb\u3057\u305f\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u5bfe\u8c61\u96c6\u56e3<\/h3>\n\n\n\n<p>\u30c9\u30a4\u30c4\u306b\u304a\u3051\u308b\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3068\u3057\u3066\u3001\u7dcf\u8a082,700\u540d\uff08CD\u60a3\u8005812\u540d\u3001UC\u60a3\u8005442\u540d\u3001\u5065\u5e38\u5bfe\u71671,446\u540d\uff09\u304c\u89e3\u6790\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u60a3\u8005\u306f\u30df\u30e5\u30f3\u30d8\u30f3\u5927\u5b66\u75c5\u9662\uff08Grosshadern\u304a\u3088\u3073Innenstadt\uff09\u304a\u3088\u3073\u30eb\u30fc\u30eb\u5927\u5b66Bochum\u3088\u308a\u767b\u9332\u3055\u308c\u3001\u75be\u60a3\u306e\u8a3a\u65ad\u306f\u5185\u8996\u93e1\u691c\u67fb\u3001\u753b\u50cf\u691c\u67fb\u3001\u75c5\u7406\u7d44\u7e54\u6240\u898b\u306b\u57fa\u3065\u3044\u3066\u78ba\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31994624_s.jpg\" alt=\"\u8a3a\u65ad\" class=\"wp-image-13168\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31994624_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31994624_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>CD\u60a3\u8005\u306e\u5206\u985e\u306b\u306f\u30e2\u30f3\u30c8\u30ea\u30aa\u30fc\u30eb\u5206\u985e\uff08Montreal classification\uff09\u304c\u4f7f\u7528\u3055\u308c\u3001\u4ee5\u4e0b\u306e\u6307\u6a19\u306b\u57fa\u3065\u3044\u3066\u5206\u985e\u304c\u884c\u308f\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u767a\u75c7\u5e74\u9f62<\/strong>\uff1aA1\uff0816\u6b73\u4ee5\u4e0b\uff09\u3001A2\uff0817\u301c40\u6b73\uff09\u3001A3\uff0840\u6b73\u4ee5\u4e0a\uff09<\/li>\n\n\n\n<li><strong>\u75c5\u5909\u90e8\u4f4d<\/strong>\uff1aL1\uff08\u7d42\u672b\u56de\u8178\uff09\u3001L2\uff08\u7d50\u8178\uff09\u3001L3\uff08\u56de\u7d50\u8178\uff09\u3001L4\uff08\u4e0a\u90e8\u6d88\u5316\u7ba1\uff09<\/li>\n\n\n\n<li><strong>\u75c5\u578b<\/strong>\uff1aB1\uff08\u975e\u72ed\u7a84\u30fb\u975e\u6d78\u6f64\u578b\uff09\u3001B2\uff08\u72ed\u7a84\u578b\uff09\u3001B3\uff08\u6d78\u6f64\u578b\uff09<\/li>\n<\/ul>\n\n\n\n<p>UC\u60a3\u8005\u306b\u3064\u3044\u3066\u3082\u3001\u30e2\u30f3\u30c8\u30ea\u30aa\u30fc\u30eb\u5206\u985e\u306b\u6e96\u3058\u3066E1\uff08\u76f4\u8178\u578b\uff09\u3001E2\uff08\u5de6\u5074\u5927\u8178\u708e\uff09\u3001E3\uff08\u5168\u5927\u8178\u708e\uff09\u306b\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u907a\u4f1d\u5b50\u578b\u89e3\u6790<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2.jpg\" alt=\"\u5b9f\u9a13\u7ba1\" class=\"wp-image-12945\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>DNA\u306f\u8840\u6db2\u304b\u3089\u62bd\u51fa\u3055\u308c\u3001SNP rs2066843\u304a\u3088\u3073rs2076756\u306f\u86cd\u5149\u5171\u9cf4\u30a8\u30cd\u30eb\u30ae\u30fc\u79fb\u52d5\uff08FRET\uff1aFluorescence Resonance Energy Transfer\uff09\u6cd5\u306b\u57fa\u3065\u304f\u30e1\u30eb\u30c6\u30a3\u30f3\u30b0\u30ab\u30fc\u30d6\u89e3\u6790\u3092\u7528\u3044\u3066LightCycler 480\u88c5\u7f6e\u306b\u3088\u308a\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u90e8\u306e\u30b5\u30f3\u30d7\u30eb\u306b\u3064\u3044\u3066\u306f\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\uff08Sanger sequencing\uff09\u306b\u3088\u308a\u78ba\u8a8d\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u4ed6\u306eNOD2\u304a\u3088\u3073ATG16L1\u306e\u5909\u7570\u306f\u3001\u5f93\u6765\u6cd5\u306b\u57fa\u3065\u3044\u3066\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\u304c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d71\u8a08\u89e3\u6790<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-2.jpg\" alt=\"\u306a\u308b\u307b\u3069\" class=\"wp-image-13418\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-2.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-2-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5bfe\u7167\u7fa4\u306b\u304a\u3044\u3066\u3001\u5404SNP\u304cHardy-Weinberg\u5e73\u8861\u306b\u3042\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u4e0a\u3067\u3001\u30ab\u30a4\u4e8c\u4e57\u691c\u5b9a\uff08\u03c7\u00b2\u691c\u5b9a\uff09\u306b\u3088\u308a\u75be\u60a3\u3068\u306e\u95a2\u9023\u6027\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u30aa\u30c3\u30ba\u6bd4\uff08Odds Ratio\uff1aOR\uff09\u306895\uff05\u4fe1\u983c\u533a\u9593\uff0895% Confidence Interval\uff1aCI\uff09\u306f\u3001\u5404SNP\u306e\u30de\u30a4\u30ca\u30fc\u30a2\u30ea\u30eb\u306b\u5bfe\u3057\u3066\u8a08\u7b97\u3055\u308c\u307e\u3057\u305f\u3002\u75be\u60a3\u8868\u73fe\u578b\u3068\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u306f\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u5206\u6790\u306b\u3088\u308a\u691c\u8a0e\u3055\u308c\u3001\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u89e3\u6790\u304a\u3088\u3073\u9023\u9396\u4e0d\u5e73\u8861\uff08Linkage Disequilibrium\uff1aLD\uff09\u89e3\u6790\u306b\u306fPLINK\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u7d50\u679c\uff5cResults<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u75be\u60a3\u611f\u53d7\u6027\u3068\u306e\u95a2\u9023<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/2326721_s.jpg\" alt=\"\u3042\u201d\" class=\"wp-image-13425\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2326721_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2326721_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>SNP rs2066843\u304a\u3088\u3073rs2076756\u306f\u3001UC\u3067\u306f\u306a\u304fCD\u306b\u304a\u3044\u3066\u6709\u610f\u306a\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002CD\u60a3\u8005\u306b\u304a\u3051\u308brs2066843\u306eT\u30a2\u30ea\u30eb\u983b\u5ea6\uff08MAF\uff09\u306f0.390\u3067\u3042\u308a\u3001\u5bfe\u7167\u7fa4\u306e0.299\u306b\u6bd4\u3079\u3066\u6709\u610f\u306b\u9ad8\u5024\u3067\u3057\u305f\uff08p = 3.01 \u00d7 10\u207b\u2075\u3001OR = 1.48\uff09\u3002rs2076756\u306eG\u30a2\u30ea\u30eb\u983b\u5ea6\u306fCD\u60a3\u8005\u30670.380\u3001\u5bfe\u7167\u7fa4\u30670.286\u3067\u3042\u308a\u3001\u3053\u3061\u3089\u3082\u6709\u610f\u306a\u5dee\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\uff08p = 4.01 \u00d7 10\u207b\u2076\u3001OR = 1.54\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u89e3\u6790<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/2326708_s.jpg\" alt=\"\u3093\u201d\" class=\"wp-image-13432\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2326708_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2326708_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>rs2066843\u304a\u3088\u3073rs2076756\u3092\u542b\u3080\u8907\u6570\u306e\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u304cCD\u3068\u5f37\u3044\u95a2\u9023\u3092\u793a\u3057\u3001\u6700\u3082\u6709\u610f\u306a\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\uff08rs2066844-rs2066845-rs2066847-rs2076756\uff09\u3067\u306f\u3001\u5168\u4f53\u306e\u6709\u610f\u6027\uff08omnibus p\u5024\uff09\u306f1.14 \u00d7 10\u207b\u00b2\u00b3\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8868\u73fe\u578b\u3068\u306e\u95a2\u9023<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/22441001_s.jpg\" alt=\"\u82e6\u3057\u307f\" class=\"wp-image-13439\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22441001_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22441001_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>rs2066843\u307e\u305f\u306frs2076756\u306e\u30db\u30e2\u63a5\u5408\u4f53\uff08homozygous carriers\uff09\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u767a\u75c7\u5e74\u9f62\u306e\u82e5\u5e74\u5316\uff08rs2076756\u3001p = 0.023\uff09<\/li>\n\n\n\n<li>\u6d78\u6f64\u578b\u75c5\u578b\uff08B3\uff09\u306e\u983b\u5ea6\u5897\u52a0\uff08rs2076756\u3001p = 0.015\uff09<\/li>\n\n\n\n<li>\u5916\u79d1\u7684\u624b\u8853\u6b74\u306e\u5897\u52a0\uff08rs2066843\uff1ap = 0.015\u3001rs2076756\uff1ap = 0.003\uff09<\/li>\n\n\n\n<li>\u763b\u5b54\u306e\u5f62\u6210\u7387\u306e\u5897\u52a0\uff08rs2076756\uff1ap = 0.015\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u4ed6\u306eNOD2\u5909\u7570\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305a\u4e00\u8cab\u3057\u3066\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u591a\u5909\u91cf\u89e3\u6790<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/1274455_s.jpg\" alt=\"\u308a\u3087\u3046\u3044\u304d\" class=\"wp-image-13446\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1274455_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/1274455_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u5206\u6790\u306b\u3088\u308a\u3001\u624b\u8853\u306e\u5fc5\u8981\u6027\u306f\u75be\u60a3\u306e\u5c40\u5728\uff08location\uff09\u304a\u3088\u3073\u75c5\u578b\uff08behavior\uff09\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u304a\u308a\u3001SNP\u306e\u907a\u4f1d\u5b50\u578b\u3092\u8aac\u660e\u5909\u6570\u306b\u8ffd\u52a0\u3057\u3066\u3082\u30e2\u30c7\u30eb\u306e\u4e88\u6e2c\u7cbe\u5ea6\u306f\u6539\u5584\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08rs2066843\uff1ap = 0.36\u3001rs2076756\uff1ap = 0.32\uff09\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30a8\u30d4\u30b9\u30bf\u30b7\u30b9\u89e3\u6790<\/h3>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs2241880-hgtIdeo_genome_7ff42_34a0d0-1024x25.png\" alt=\"rs2241880\" class=\"wp-image-13453\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2241880-hgtIdeo_genome_7ff42_34a0d0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2241880-hgtIdeo_genome_7ff42_34a0d0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2241880-hgtIdeo_genome_7ff42_34a0d0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2241880-hgtIdeo_genome_7ff42_34a0d0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>NOD2\u5909\u7570\u3068ATG16L1\uff08rs2241880\uff09\u5909\u7570\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u907a\u4f1d\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\uff08epistasis\uff09\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u4e21\u8005\u304c\u6a5f\u80fd\u7684\u306b\u306f\u9023\u643a\u3059\u308b\u3082\u306e\u306e\u3001\u907a\u4f1d\u7684\u5f71\u97ff\u306f\u72ec\u7acb\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d50\u8ad6\uff5cConclusion<\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/2326717_s.jpg\" alt=\"\u3059\u3063\u304d\u308a\" class=\"wp-image-13460\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2326717_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2326717_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>NOD2\u907a\u4f1d\u5b50\u306b\u304a\u3051\u308brs2066843\u304a\u3088\u3073rs2076756\u306f\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u306b\u5bfe\u3059\u308b\u65b0\u898f\u304b\u3064\u5171\u901a\u3059\u308b\u611f\u53d7\u6027\u5909\u7570\u3067\u3042\u308b\u3053\u3068\u304c\u672c\u7814\u7a76\u306b\u3088\u308a\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306eSNP\u306f\u3001\u9ad8\u983b\u5ea6\u3067\u5b58\u5728\u3057\u3001\u767a\u75c7\u30ea\u30b9\u30af\u306e\u5897\u52a0\u304a\u3088\u3073\u75be\u60a3\u306e\u91cd\u75c7\u5316\uff08\u6d78\u6f64\u578b\u3001\u65e9\u671f\u767a\u75c7\u3001\u763b\u5b54\u5f62\u6210\u3001\u624b\u8853\u6b74\uff09\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u624b\u8853\u306e\u5fc5\u8981\u6027\u3092\u4e88\u6e2c\u3059\u308b\u4e0a\u3067\u306f\u3001\u75c5\u5909\u90e8\u4f4d\u3084\u75c5\u578b\u306e\u65b9\u304c\u3088\u308a\u5f37\u529b\u306a\u56e0\u5b50\u3067\u3042\u308a\u3001\u3053\u308c\u3089\u306eSNP\u5358\u72ec\u3067\u306f\u5341\u5206\u306a\u4e88\u6e2c\u56e0\u5b50\u3068\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u4eca\u5f8c\u306f\u3001\u3055\u3089\u306a\u308b\u6a5f\u80fd\u89e3\u6790\u304a\u3088\u3073\u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u3092\u7528\u3044\u305f\u8ffd\u8a66\u304c\u5fc5\u8981\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31872973_s.jpg\" alt=\"\u5927\u4e08\u592b\" class=\"wp-image-13467\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31872973_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31872973_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u73fe\u5728\u306e\u3068\u3053\u308d\u3001rs2066843\u304a\u3088\u3073rs2076756\u306f\u3001\u65e2\u5b58\u306eCD\u95a2\u9023NOD2\u5909\u7570\uff08rs2066844\u3001rs2066847\uff09\u306b\u4ee3\u308f\u3063\u3066\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u4f7f\u7528\u3055\u308c\u308b\u6bb5\u968e\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u5c06\u6765\u7684\u306b\u306f\u88dc\u52a9\u7684\u306a\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u6d3b\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>NOD2, rs2066843, rs2076756, ATG16L1, \u30af\u30ed\u30fc\u30f3\u75c5\uff08Crohn\u2019s disease\uff09, \u4e00\u5869\u57fa\u591a\u578b\uff08single nucleotide polymorphism\uff09, \u907a\u4f1d\u578b\u30fb\u8868\u73fe\u578b\u76f8\u95a2\uff08genotype-phenotype correlation\uff09, \u708e\u75c7\u6027\u8178\u75be\u60a3\uff08inflammatory bowel disease\uff09, \u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\uff08haplotype\uff09, \u30a8\u30d4\u30b9\u30bf\u30b7\u30b9\uff08epistasis\uff09, \u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08autophagy\uff09<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32037717_s.jpg\" alt=\"\u3086\u3073\u3086\u3073\" class=\"wp-image-11971\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32037717_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32037717_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0014466\">Glas, J., Seiderer, J., Tillack, C., Pfennig, S., Beigel, F., J\u00fcrgens, M., Olszak, T., Laubender, R. P., Weidinger, M., M\u00fcller-Myhsok, B., G\u00f6ke, B., Ochsenk\u00fchn, T., Lohse, P., Diegelmann, J., Czamara, D., &amp; Brand, S. (2010). The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn&#8217;s disease susceptibility gene variants.\u00a0<em>PloS one<\/em>,\u00a0<em>5<\/em>(12), e14466. https:\/\/doi.org\/10.1371\/journal.pone.0014466<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u30af\u30ed\u30fc\u30f3\u75c5\uff08Crohn&#8217;s disease\uff1aCD\uff09\u304a\u3088\u3073\u6f70\u760d\u6027\u5927\u8178\u708e\uff08Ulcerative colitis\uff1aUC\uff09\u306f\u3001\u8178\u7ba1\u306b\u6162\u6027\u7684\u306a\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u708e\u75c7\u6027\u8178\u75be\u60a3\uff08Inflammat [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":13260,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[520,525,529,533,522,242,523,532,519,530,534,527,528,531,524,225,521,526,57],"class_list":["post-13332","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-atg16l1","tag-nf-b","tag-nod2","tag-rs2066843","tag-rs2076756","tag-snp","tag-523","tag-532","tag-519","tag-530","tag-534","tag-527","tag-528","tag-531","tag-524","tag-225","tag-521","tag-526","tag-57"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/13332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=13332"}],"version-history":[{"count":7,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/13332\/revisions"}],"predecessor-version":[{"id":13474,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/13332\/revisions\/13474"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/13260"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=13332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=13332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=13332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}