{"id":13475,"date":"2025-04-07T05:28:48","date_gmt":"2025-04-07T05:28:48","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=13475"},"modified":"2025-04-07T05:28:49","modified_gmt":"2025-04-07T05:28:49","slug":"asthma","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/asthma\/","title":{"rendered":"\u5598\u606f\u306e\u539f\u56e0\u306f\u907a\u4f1d\u5b50\uff1f\u6700\u65b0\u7814\u7a76\u3067\u308f\u304b\u3063\u3066\u304d\u305f\u201c\u4f53\u8cea\u201d\u3068\u306e\u95a2\u4fc2"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u80cc\u666f\uff5cBackground<\/strong><\/h2>\n\n\n\n<p>\u6c17\u7ba1\u652f\u5598\u606f\uff08\u4ee5\u4e0b\u3001\u5598\u606f\uff09\u306f\u3001\u6c17\u9053\u306e\u6162\u6027\u708e\u75c7\u3092\u7279\u5fb4\u3068\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u6c17\u6d41\u5236\u9650\u306e\u53ef\u9006\u6027\u3001\u6c17\u9053\u904e\u654f\u6027\uff08bronchial hyperresponsiveness\uff1aBHR\uff09\u3001\u304a\u3088\u3073\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u4f34\u3044\u307e\u3059\u3002\u4e16\u754c\u4e2d\u30673\u5104\u4eba\u4ee5\u4e0a\u304c\u7f79\u60a3\u3057\u3066\u304a\u308a\u3001\u5598\u9cf4\u3001\u54b3\u55fd\u3001\u547c\u5438\u56f0\u96e3\u3001\u80f8\u90e8\u5727\u8feb\u611f\u306a\u3069\u306e\u75c7\u72b6\u3092\u5448\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"428\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/2693507_s.jpg\" alt=\"\u5598\u606f\" class=\"wp-image-13490\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2693507_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/2693507_s-300x201.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5598\u606f\u306f\u591a\u69d8\u306a\u8868\u73fe\u578b\uff08\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\uff09\u3092\u6301\u3064\u7570\u8cea\u6027\u306e\u9ad8\u3044\u75be\u60a3\u3067\u3042\u308a\u3001\u30a2\u30c8\u30d4\u30fc\u578b\u5598\u606f\uff08IgE\u95a2\u9023\uff09\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u904e\u654f\u5598\u606f\uff08aspirin-intolerant asthma\uff1aAIA\uff09\u306a\u3069\u306e\u4e9c\u578b\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u5598\u606f\u306e\u7f79\u60a3\u306b\u306f\u907a\u4f1d\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u8907\u96d1\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u907a\u4f1d\u7684\u5bc4\u4e0e\u7387\u306f50\u301c60%\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u306e\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790\uff08genome-wide association studies\uff1aGWAS\uff09\u3084\u5019\u88dc\u907a\u4f1d\u5b50\u7814\u7a76\uff08candidate gene studies\uff09\u306b\u3088\u3063\u3066\u3001\u591a\u6570\u306e\u4e00\u5869\u57fa\u591a\u578b\uff08single nucleotide polymorphisms\uff1aSNPs\uff09\u304c\u540c\u5b9a\u3055\u308c\u3001\u5598\u606f\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3001\u75be\u60a3\u91cd\u75c7\u5ea6\u3001\u514d\u75ab\u5fdc\u7b54\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u306a\u3069\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968510_s.jpg\" alt=\"\u30d4\u30da\u30c3\u30c8\" class=\"wp-image-12924\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968510_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968510_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7a3f\u3067\u306f\u3001\u30e1\u30bf\u89e3\u6790\u3001\u6c11\u65cf\u96c6\u56e3\u5225\u306e\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3001\u767a\u73fe\u89e3\u6790\u3001eQTL\uff08expression quantitative trait loci\uff09\u7814\u7a76\u3068\u3044\u3063\u305f\u9ad8\u54c1\u8cea\u306a\u7814\u7a76\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u5598\u606f\u306e\u75c5\u56e0\u304a\u3088\u3073\u6cbb\u7642\u500b\u5225\u5316\u306b\u95a2\u308f\u308b\u907a\u4f1d\u7684\u80cc\u666f\u3092\u5305\u62ec\u7684\u306b\u660e\u3089\u304b\u306b\u3057\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u95a2\u9023\u907a\u4f1d\u5b50\uff06SNP\uff08Single Nucleotide Polymorphism; \u4e00\u5869\u57fa\u591a\u578b\uff09\uff5cAssociated Genes &amp; SNPs<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>IL-4\uff08rs2243250, C-589T\uff09<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs2243250-hgtIdeo_genome_15db11_35a370-1024x25.png\" alt=\"rs2243250\" class=\"wp-image-13511\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2243250-hgtIdeo_genome_15db11_35a370-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2243250-hgtIdeo_genome_15db11_35a370-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2243250-hgtIdeo_genome_15db11_35a370-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs2243250-hgtIdeo_genome_15db11_35a370.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a5f\u80fd\uff1aIL-4\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f34\uff09\u306f\u4e3b\u306bTh2\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u3001IgE\u6297\u4f53\u7523\u751f\u306e\u4fc3\u9032\u3084Th2\u578b\u514d\u75ab\u53cd\u5fdc\u306e\u8a98\u5c0e\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u30b2\u30ce\u30e0\u4f4d\u7f6e\uff1a\u67d3\u8272\u4f535q31\u3002\u514d\u75ab\u95a2\u9023\u907a\u4f1d\u5b50\u304c\u96c6\u7a4d\u3059\u308b\u9818\u57df\u3067\u3059\u3002<\/li>\n\n\n\n<li>SNP\u306e\u5f71\u97ff\uff1a\u2212589T\u30a2\u30ec\u30eb\uff08rs2243250\uff09\u306f\u8ee2\u5199\u56e0\u5b50\u306e\u7d50\u5408\u89aa\u548c\u6027\u3092\u9ad8\u3081\u3001IL-4\u306e\u767a\u73fe\u3092\u4e0a\u6607\u3055\u305b\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u30e1\u30bf\u89e3\u6790\uff0817\u7814\u7a76\u3001N = 6070\uff09\uff1a\n<ul class=\"wp-block-list\">\n<li>T\u30a2\u30ec\u30eb\u4fdd\u6301\u8005\uff08CT\u304a\u3088\u3073TT\uff09\u306f\u5598\u606f\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u9ad8\u304f\u3001\u3068\u304f\u306b\u767d\u4eba\u304a\u3088\u3073\u30a2\u30c8\u30d4\u30fc\u578b\u5598\u606f\u60a3\u8005\u3067\u5f37\u3044\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u30c9\u30df\u30ca\u30f3\u30c8\u30e2\u30c7\u30eb\uff08CT+TT vs. CC\uff09\uff1a\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09= 1.213\u300195%\u4fe1\u983c\u533a\u9593\uff08CI\uff09\uff1a1.046\u20131.405<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>IL-4R\u03b1\uff08rs1801275\uff1aQ576R\u3001rs1805010\uff1aI75V\uff09<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs1801275-hgtIdeo_genome_1afa4b_35f2c0-1024x25.png\" alt=\"rs1801275\" class=\"wp-image-13519\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1801275-hgtIdeo_genome_1afa4b_35f2c0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1801275-hgtIdeo_genome_1afa4b_35f2c0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1801275-hgtIdeo_genome_1afa4b_35f2c0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1801275-hgtIdeo_genome_1afa4b_35f2c0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a5f\u80fd\uff1aIL-4\u53d7\u5bb9\u4f53\u03b1\u9396\uff08IL-4R\u03b1\uff09\u306f\u3001IL-4\u304a\u3088\u3073IL-13\u306e\u5171\u901a\u53d7\u5bb9\u4f53\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3067\u3042\u308a\u3001STAT6\uff08Signal Transducer and Activator of Transcription 6\uff09\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066Th2\u578b\u708e\u75c7\u5fdc\u7b54\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u5909\u7570\u306e\u7279\u5fb4\uff1a\n<ul class=\"wp-block-list\">\n<li>rs1801275\uff08Q576R\uff09\uff1a\u30b0\u30eb\u30bf\u30df\u30f3\u2192\u30a2\u30eb\u30ae\u30cb\u30f3\u3078\u306e\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u3002<\/li>\n\n\n\n<li>rs1805010\uff08I75V\uff09\uff1a\u30a4\u30bd\u30ed\u30a4\u30b7\u30f3\u2192\u30d0\u30ea\u30f3\u3078\u306e\u7f6e\u63db\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u30b5\u30a6\u30b8\u30a2\u30e9\u30d3\u30a2\u4eba\u96c6\u56e3\uff08n = 384\uff09\uff1a\n<ul class=\"wp-block-list\">\n<li>rs1801275\u306eG\u30a2\u30ec\u30eb\uff08R\u578b\uff09\u306f\u5598\u606f\u30ea\u30b9\u30af\u3092\u4e0a\u6607\uff08OR = 2.12\uff09\u3002\u5973\u6027\u3067\u7279\u306b\u5f37\u3044\u52b9\u679c\uff08OR = 2.92\uff09\u3002<\/li>\n\n\n\n<li>rs1805010\u306eG\u30a2\u30ec\u30eb\u3082\u6709\u610f\u306a\u95a2\u9023\u3042\u308a\uff08OR = 1.6\uff09\u3002<\/li>\n\n\n\n<li>\u4e21SNP\u306eG-G\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u4fdd\u6301\u8005\u3067\u306f\u3001\u3088\u308a\u5f37\u3044\u30ea\u30b9\u30af\u5897\u52a0\uff08OR = 2.43\uff09\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>IL-13\uff08rs1800925, \u22121111C>T\uff09<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs1800925-hgtIdeo_genome_1b7af9_35f790-1024x25.png\" alt=\"rs1800925\" class=\"wp-image-13533\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1800925-hgtIdeo_genome_1b7af9_35f790-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1800925-hgtIdeo_genome_1b7af9_35f790-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1800925-hgtIdeo_genome_1b7af9_35f790-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs1800925-hgtIdeo_genome_1b7af9_35f790.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a5f\u80fd\uff1aIL-13\u306f\u6c17\u9053\u904e\u654f\u6027\u3001\u7c98\u6db2\u5206\u6ccc\u3001\u597d\u9178\u7403\u6d78\u6f64\u3001IgE\u7523\u751f\u306b\u95a2\u4e0e\u3057\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u708e\u75c7\u306e\u4e3b\u8981\u56e0\u5b50\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>SNP\u306e\u7279\u5fb4\uff1a\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306e\u5909\u7570\u3067\u3042\u308a\u3001\u907a\u4f1d\u5b50\u8ee2\u5199\u306e\u4fc3\u9032\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u30a2\u30b8\u30a2\u4eba\u5bfe\u8c61\u306e\u30e1\u30bf\u89e3\u6790\uff0811\u7814\u7a76\u3001N = 5809\uff09\uff1a\n<ul class=\"wp-block-list\">\n<li>TT\u907a\u4f1d\u578b\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u5598\u606f\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u6607\uff08OR = 1.48\uff09\u3002<\/li>\n\n\n\n<li>West Asians\uff08\u897f\u30a2\u30b8\u30a2\u4eba\uff09\u3068\u6210\u4eba\u306b\u304a\u3044\u3066\u7279\u306b\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u9855\u8457\u3067\u3057\u305f\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>IL-13\uff08rs20541, Arg130Gln\uff09<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/rs20541-hgtIdeo_genome_1bca5b_35f9f0-1024x25.png\" alt=\"rs20541\" class=\"wp-image-13540\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs20541-hgtIdeo_genome_1bca5b_35f9f0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs20541-hgtIdeo_genome_1bca5b_35f9f0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs20541-hgtIdeo_genome_1bca5b_35f9f0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/rs20541-hgtIdeo_genome_1bca5b_35f9f0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a5f\u80fd\uff1a\u3053\u306e\u5909\u7570\u306f\u30a2\u30df\u30ce\u9178130\u756a\u76ee\u306e\u30a2\u30eb\u30ae\u30cb\u30f3\u2192\u30b0\u30eb\u30bf\u30df\u30f3\u7f6e\u63db\u3092\u751f\u3058\u3001IL-13\u306e\u53d7\u5bb9\u4f53\u7d50\u5408\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u5c0f\u5150\u5598\u606f\u60a3\u8005\u5bfe\u8c61\u7814\u7a76\uff08n = 50\uff09\uff1a\n<ul class=\"wp-block-list\">\n<li>GG\u578b\u306e\u5150\u7ae5\u306f\u3001\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\uff08ICS\uff09\uff0b\u9577\u6642\u9593\u4f5c\u7528\u578b\u03b22\u523a\u6fc0\u85ac\uff08LABA\uff09\u6cbb\u7642\u5f8c\u306e\u75c7\u72b6\u6539\u5584\u304a\u3088\u3073\u80ba\u6a5f\u80fd\u56de\u5fa9\u304c\u4ed6\u7fa4\u3088\u308a\u6709\u610f\u306b\u901f\u304f\uff08P &lt; 0.001\uff09\u3001\u6cbb\u7642\u53cd\u5fdc\u6027\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>ADAM33\uff08ST+7\u3001V-1\u3001V5\uff09<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/ADAM33-hgtIdeo_genome_2e736c_360240-1024x25.png\" alt=\"ADAM33\" class=\"wp-image-13547\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/ADAM33-hgtIdeo_genome_2e736c_360240-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/ADAM33-hgtIdeo_genome_2e736c_360240-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/ADAM33-hgtIdeo_genome_2e736c_360240-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/ADAM33-hgtIdeo_genome_2e736c_360240.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a5f\u80fd\uff1aADAM33\u306f\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\u3001\u6c17\u9053\u5e73\u6ed1\u7b4b\u3084\u7dda\u7dad\u82bd\u7d30\u80de\u3067\u767a\u73fe\u3057\u3001\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3084\u708e\u75c7\u53cd\u5fdc\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u65e5\u672c\u4eba\u96c6\u56e3\u306b\u304a\u3051\u308bAIA\u3068\u306e\u95a2\u9023\uff1a\n<ul class=\"wp-block-list\">\n<li>\u4e0a\u8a183\u3064\u306eSNP\u306b\u304a\u3044\u3066\u3001AIA\u7fa4 vs. ATA\u7fa4\/\u5bfe\u7167\u7fa4\u3067\u6709\u610f\u306a\u5bfe\u7acb\u907a\u4f1d\u5b50\u983b\u5ea6\u306e\u5dee\uff08P = 0.004\u20130.034\uff09\u3002<\/li>\n\n\n\n<li>G-C-A\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u304cAIA\u3067\u904e\u5270\u306b\u5b58\u5728\u3057\u3001AIA\u7279\u7570\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u30ea\u30f3\u30af\u4e0d\u5e73\u8861\uff08LD\uff09\u306f\u9ad8\u5024\uff08D&#8217; = 0.91\u20130.99\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>ORMDL3\uff08rs4378650\u3001rs12603332\u3001rs7216389\uff09<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/ORMDL3-hgtIdeo_genome_2ec6d4_360600-1024x25.png\" alt=\"ORMDL3\" class=\"wp-image-13554\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/ORMDL3-hgtIdeo_genome_2ec6d4_360600-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/ORMDL3-hgtIdeo_genome_2ec6d4_360600-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/ORMDL3-hgtIdeo_genome_2ec6d4_360600-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/ORMDL3-hgtIdeo_genome_2ec6d4_360600.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a5f\u80fd\uff1aORMDL3\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3084\u30b9\u30d5\u30a3\u30f3\u30b4\u8102\u8cea\u5408\u6210\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u3001\u6c17\u9053\u4e0a\u76ae\u306e\u514d\u75ab\u6052\u5e38\u6027\u7dad\u6301\u306b\u91cd\u8981\u3067\u3059\u3002<\/li>\n\n\n\n<li>\u591a\u6c11\u65cf\u96c6\u56e3\uff08\u30d7\u30a8\u30eb\u30c8\u30ea\u30b3\u7cfb\u3001\u30e1\u30ad\u30b7\u30b3\u7cfb\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\uff09\uff1a\n<ul class=\"wp-block-list\">\n<li>rs4378650\uff08C\u30a2\u30ec\u30eb\uff09\uff1aOR = 1.39\u3001P = 5.7 \u00d7 10\u207b\u2076<\/li>\n\n\n\n<li>rs12603332\uff08C\u30a2\u30ec\u30eb\uff09\uff1aOR = 1.38\u3001P = 2.4 \u00d7 10\u207b\u2075<\/li>\n\n\n\n<li>\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u5598\u606f\uff08IgE > 100 IU\/mL\uff09\u3067\u95a2\u9023\u304c\u7279\u306b\u5f37\u304f\u3001\u30a2\u30c8\u30d4\u30fc\u578b\u5598\u606f\u306e\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>GSDMB\uff08rs2305479\u3001rs62067034\u3001rs1031458\u3001rs3902920\uff09<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/GSDMB-hgtIdeo_genome_2efaf9_360810-1024x25.png\" alt=\"GSDMB\" class=\"wp-image-13561\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GSDMB-hgtIdeo_genome_2efaf9_360810-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GSDMB-hgtIdeo_genome_2efaf9_360810-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GSDMB-hgtIdeo_genome_2efaf9_360810-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GSDMB-hgtIdeo_genome_2efaf9_360810.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a5f\u80fd\uff1aGSDMB\u306f\u6c17\u9053\u4e0a\u76ae\u7d30\u80de\u306e\u708e\u75c7\u30fb\u7d30\u80de\u6b7b\u53cd\u5fdc\u306b\u95a2\u4e0e\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5fdc\u7b54\u306e\u8abf\u7bc0\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>SARP\uff08Severe Asthma Research Program\uff09\u30c7\u30fc\u30bf\uff1a\n<ul class=\"wp-block-list\">\n<li>rs2305479\uff0frs62067034\u306f\u91cd\u75c7\u5598\u606f\u3068\u95a2\u9023\uff08OR = 1.34\u3001P = 0.0029\uff09\u3002<\/li>\n\n\n\n<li>rs1031458\uff0frs3902920\u306f\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u8abf\u7bc0\u56e0\u5b50\uff08IRF1\/2\/4\uff09\u7d50\u5408\u9818\u57df\u306b\u4f4d\u7f6e\u3057\u3001\u5598\u606f\u5897\u60aa\u3084\u65e9\u671f\u767a\u75c7\u578b\u5598\u606f\uff08P &lt; 1 \u00d7 10\u207b\u2075\uff09\u3068\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>GSTP1\uff08Ile105Val\uff09<\/strong><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"25\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/GSTP1-hgtIdeo_genome_2f3b95_360ba0-1024x25.png\" alt=\"GSTP1\" class=\"wp-image-13575\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GSTP1-hgtIdeo_genome_2f3b95_360ba0-1024x25.png 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GSTP1-hgtIdeo_genome_2f3b95_360ba0-300x7.png 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GSTP1-hgtIdeo_genome_2f3b95_360ba0-768x18.png 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/GSTP1-hgtIdeo_genome_2f3b95_360ba0.png 1124w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a5f\u80fd\uff1aGSTP1\u306f\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306e\u89e3\u6bd2\u9175\u7d20\u3067\u3042\u308a\u3001\u80ba\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u9632\u5fa1\u306b\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u62c5\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>\u7814\u7a76\u96c6\u56e3\uff1a\u6b27\u5dde\u7cfb\u767d\u4eba\uff08n = 202\uff09<\/li>\n\n\n\n<li>Val105\/Val105\u907a\u4f1d\u578b\u306f\u3001\u4ee5\u4e0b\u306b\u5bfe\u3057\u3066\u9632\u5fa1\u7684\uff1a\n<ul class=\"wp-block-list\">\n<li>\u5598\u606f\uff08OR = 0.16\uff09<\/li>\n\n\n\n<li>BHR\uff08OR = 0.23\uff09<\/li>\n\n\n\n<li>\u30a2\u30c8\u30d4\u30fc\uff08P = 0.010\uff09<\/li>\n\n\n\n<li>\u52b9\u679c\u306f\u907a\u4f1d\u5b50\u91cf\u4f9d\u5b58\u7684\uff08\u30db\u30e2\uff1e\u30d8\u30c6\u30ed\uff1e\u975e\u4fdd\u6709\uff09\u3067\u3057\u305f\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8003\u5bdf\uff1a\u3053\u306e\u7814\u7a76\u304b\u3089\u4f55\u304c\u5206\u304b\u3063\u305f\u306e\u304b\uff1f\uff5cDiscussion<\/strong><\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"480\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/27944563_s.jpg\" alt=\"\u5598\u606f\" class=\"wp-image-13497\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/27944563_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/27944563_s-300x225.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u7d71\u5408\u5206\u6790\u304b\u3089\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u306e\u306f\u3001\u5598\u606f\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306f\u591a\u907a\u4f1d\u5b50\u6027\uff08polygenic\uff09\u3067\u3042\u308a\u3001\u4eba\u7a2e\u30fb\u6c11\u65cf\u3054\u3068\u306e\u9055\u3044\uff08ethnic heterogeneity\uff09<strong>\u3084<\/strong>\u75be\u60a3\u8868\u73fe\u578b\u306e\u591a\u69d8\u6027\uff08phenotypic diversity\uff09\u304c\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u91cd\u8981\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IL-4\u3001IL-13\u304a\u3088\u3073\u305d\u306e\u53d7\u5bb9\u4f53\uff08IL-4R\u03b1\uff09\u306f\u3001\u30a2\u30c8\u30d4\u30fc\u578b\u5598\u606f\uff08IgE\u3092\u4f34\u3046\u30bf\u30a4\u30d72\u708e\u75c7\uff09\u306b\u4e00\u8cab\u3057\u3066\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306f\u597d\u9178\u7403\u6027\u708e\u75c7\u3084IgE\u7523\u751f\u3068\u3044\u3063\u305f\u514d\u75ab\u53cd\u5fdc\u306e\u5f37\u3055\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li>IL-4R\u03b1\u306e\u5909\u7570\u306f\u7279\u306b\u5973\u6027\u3067\u5598\u606f\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304b\u3089\u3001\u6027\u5dee\u306b\u95a2\u9023\u3057\u305f\u514d\u75ab\u5fdc\u7b54\u306e\u907a\u4f1d\u5236\u5fa1\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/li>\n\n\n\n<li>ADAM33\u306e\u591a\u578b\u306f\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u904e\u654f\u5598\u606f\uff08AIA\uff09\u3068\u3044\u3046\u72ec\u7acb\u3057\u305f\u8868\u73fe\u578b\u306b\u7279\u7570\u7684\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001NSAID\uff08\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac\uff09\u8a98\u767a\u6027\u306e\u91cd\u5ea6\u6c17\u9053\u53ce\u7e2e\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"689\" height=\"321\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P05112-F1.png\" alt=\"Interleukin-4\" class=\"wp-image-13582\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P05112-F1.png 689w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P05112-F1-300x140.png 300w\" sizes=\"(max-width: 689px) 100vw, 689px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>GSDMB\u907a\u4f1d\u5b50\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u6642\u306e\u4e0a\u76ae\u5fdc\u7b54\u3068\u5598\u606f\u5897\u60aa\u306b\u95a2\u4fc2\u3057\u3001\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u4ecb\u3057\u305f\u975e\u30a2\u30c8\u30d4\u30fc\u578b\u5598\u606f\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li>ORMDL3\u907a\u4f1d\u5b50\u306e\u591a\u578b\u306f\u8907\u6570\u306e\u6c11\u65cf\u96c6\u56e3\u306b\u304a\u3044\u3066\u518d\u73fe\u6027\u306e\u9ad8\u3044\u95a2\u9023\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u300117\u756a\u67d3\u8272\u4f53q12-21.2\u9818\u57df\u304c\u5598\u606f\u5168\u4f53\u306e\u5171\u901a\u611f\u53d7\u6027\u9818\u57df\u3067\u3042\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u307e\u3059\u3002<\/li>\n\n\n\n<li>GSTP1\u306eVal105\u30a2\u30ec\u30eb\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u4f5c\u7528\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u3001\u5598\u606f\u30fbBHR\u30fb\u30a2\u30c8\u30d4\u30fc\u306b\u5bfe\u3057\u3066\u4fdd\u8b77\u7684\u306b\u4f5c\u7528\u3057\u3066\u304a\u308a\u3001\u80ba\u306e\u6297\u9178\u5316\u80fd\u529b\u304c\u75be\u60a3\u767a\u75c7\u3084\u9032\u884c\u306b\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"679\" height=\"338\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/AF-P05112-F1-1.png\" alt=\"Interleukin-4\" class=\"wp-image-13589\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P05112-F1-1.png 679w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/AF-P05112-F1-1-300x149.png 300w\" sizes=\"(max-width: 679px) 100vw, 679px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u5598\u606f\u306e\u5206\u5b50\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u57fa\u3065\u304f\u500b\u5225\u5316\u533b\u7642\uff08precision medicine\uff09\u306e\u5b9f\u73fe\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u6cbb\u7642\u65b9\u91dd\u6c7a\u5b9a\u306b\u304a\u3044\u3066\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u304f\u30ea\u30b9\u30af\u5c64\u5225\u5316\u3084\u6cbb\u7642\u9078\u629e\u304c\u91cd\u8981\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u65b9\u6cd5\uff5cMethods<\/strong><\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-2.jpg\" alt=\"\u306a\u308b\u307b\u3069\" class=\"wp-image-13418\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-2.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31397209_s-2-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30bf\u89e3\u6790\uff1aPRISMA\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304d\u6587\u732e\u691c\u7d22\u3092\u884c\u3044\u3001\u30cf\u30fc\u30c7\u30a3\u30fc\u30fb\u30ef\u30a4\u30f3\u30d9\u30eb\u30b0\u5e73\u8861\uff08Hardy\u2013Weinberg Equilibrium\uff09\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3001\u6c11\u65cf\u5225\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306a\u3069\u306e\u57fa\u6e96\u306b\u57fa\u3065\u3044\u3066\u5bfe\u8c61\u7814\u7a76\u3092\u9078\u5b9a\u3057\u3001\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u30e2\u30c7\u30eb\uff08\u5171\u512a\u6027\u3001\u512a\u6027\u3001\u52a3\u6027\uff09\u3067\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09\u3092\u7b97\u51fa\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\uff1a\u30ab\u30a4\u4e8c\u4e57\u691c\u5b9a\uff08Pearson&#8217;s \u03c7\u00b2\uff09\u3001Yates\u88dc\u6b63\u3001\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u907a\u4f1d\u5b50\u578b\u30fb\u5bfe\u7acb\u907a\u4f1d\u5b50\u983b\u5ea6\u306e\u5dee\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>eQTL\u89e3\u6790\uff1a\u6c17\u7ba1\u652f\u4e0a\u76ae\u7d30\u80de\uff08bronchial epithelial cells\uff1aBEC\uff09\u7531\u6765\u306eRNA\u30b7\u30fc\u30b1\u30f3\u30b9\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3068SNP\u3068\u306e\u95a2\u9023\uff08expression quantitative trait loci\uff09\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2.jpg\" alt=\"\u5b9f\u9a13\u7ba1\" class=\"wp-image-12945\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31968306_s-2-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5171\u5c40\u5728\uff08Colocalization\uff09\u30e2\u30c7\u30eb\uff1a\u30d9\u30a4\u30ba\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u540c\u4e00SNP\u304c\u75be\u60a3\u8868\u73fe\u578b\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u4e21\u65b9\u306b\u95a2\u4e0e\u3059\u308b\u304b\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u89e3\u6790\u3068LD\u8a55\u4fa1\uff1aEM\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u7528\u3044\u3066\u8907\u6570SNP\u306e\u7d44\u307f\u5408\u308f\u305b\uff08\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\uff09\u306e\u983b\u5ea6\u3092\u63a8\u5b9a\u3057\u3001D\u2019\u5024\u3084r\u00b2\u5024\u3092\u7528\u3044\u3066\u9023\u9396\u4e0d\u5e73\u8861\uff08linkage disequilibrium\uff09\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u7d4c\u8def\u89e3\u6790\uff08Pathway enrichment\uff09\uff1aReactome\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u7528\u3044\u3066\u3001\u5171\u767a\u73fe\u907a\u4f1d\u5b50\u7fa4\u304c\u95a2\u4e0e\u3059\u308b\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306e\u5bcc\u5316\u5206\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/30285039_s.jpg\" alt=\"\u9855\u5fae\u93e1\u3067\u30c1\u30e9\u30c3\u3068\" class=\"wp-image-12959\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30285039_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/30285039_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u7d50\u679c\uff5cResults<\/strong><\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/22832661_s.jpg\" alt=\"\u5598\u606f\" class=\"wp-image-13504\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22832661_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22832661_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IL-4 rs2243250\uff08\u2212589T\u30a2\u30ec\u30eb\uff09\u306f\u5598\u606f\u611f\u53d7\u6027\u3092\u6709\u610f\u306b\u9ad8\u3081\u3001\u3068\u304f\u306b\u30a2\u30c8\u30d4\u30fc\u578b\u304a\u3088\u3073\u767d\u4eba\u96c6\u56e3\u3067\u5f37\u3044\u5f71\u97ff\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\uff08OR = 1.213\uff09\u3002<\/li>\n\n\n\n<li>IL-4R\u03b1\u306e2\u3064\u306eSNP\uff08rs1801275\u3001rs1805010\uff09\u306f\u3044\u305a\u308c\u3082\u5598\u606f\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u7279\u306b\u5973\u6027\u3067\u306f\u30ea\u30b9\u30af\u4e0a\u6607\u304c\u9855\u8457\u3067\u3057\u305f\u3002<\/li>\n\n\n\n<li>IL-13 rs1800925\uff08\u22121111T\uff09\u306f\u30a2\u30b8\u30a2\u4eba\u96c6\u56e3\u306b\u304a\u3044\u3066\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u5598\u606f\u306e\u30ea\u30b9\u30af\u3092\u5897\u5927\u3055\u305b\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>rs20541\uff08Arg130Gln\uff09\u306eGG\u578b\u306f\u3001\u5438\u5165\u85ac\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u6027\u304c\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u304c\u5c0f\u5150\u5598\u606f\u60a3\u8005\u306b\u304a\u3044\u3066\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"512\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/32005680_s.jpg\" alt=\"ikidekinai\" class=\"wp-image-13596\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32005680_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/32005680_s-300x240.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ADAM33\uff08ST+7, V-1, V5\uff09\u306f\u3001\u65e5\u672c\u4eba\u306b\u304a\u3044\u3066AIA\u304a\u3088\u3073\u5598\u606f\u91cd\u75c7\u5ea6\u3068\u6709\u610f\u306b\u95a2\u9023\u3002<\/li>\n\n\n\n<li>ORMDL3\uff08rs4378650\u3001rs12603332\uff09\u306f\u3001\u30d7\u30a8\u30eb\u30c8\u30ea\u30b3\u7cfb\u3001\u30e1\u30ad\u30b7\u30b3\u7cfb\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u306e\u8907\u6570\u96c6\u56e3\u3067\u5598\u606f\u30ea\u30b9\u30af\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>GSDMB\u907a\u4f1d\u5b50\u306eSNP\u7fa4\u306f\u3001\u5598\u606f\u91cd\u75c7\u5ea6\u3001\u5897\u60aa\u56de\u6570\u3001FeNO\u5024\u4e0a\u6607\u3001\u30b3\u30eb\u30c1\u30b3\u30b9\u30c6\u30ed\u30a4\u30c9\u5fdc\u7b54\u6027\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/li>\n\n\n\n<li>GSTP1 Val105\/Val105\u306f\u3001\u5598\u606f\u3001BHR\u3001\u30a2\u30c8\u30d4\u30fc\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u308b\u4fdd\u8b77\u7684\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/31039851_s.jpg\" alt=\"\u606f\u3067\u304d\u306a\u3044\" class=\"wp-image-13605\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31039851_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/31039851_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7d50\u8ad6\uff5cConclusion<\/strong><\/h2>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/22349115_s.jpg\" alt=\"\u9178\u7d20\u3092\u5438\u3046\" class=\"wp-image-13612\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22349115_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22349115_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5598\u606f\u306e\u611f\u53d7\u6027\u30fb\u91cd\u75c7\u5ea6\u30fb\u6cbb\u7642\u53cd\u5fdc\u6027\u306f\u3001\u514d\u75ab\u8abf\u7bc0\u907a\u4f1d\u5b50\uff08IL-4\u3001IL-13\u3001IL-4R\u03b1\uff09\u3001\u4e0a\u76ae\u6a5f\u80fd\u95a2\u9023\u907a\u4f1d\u5b50\uff08ORMDL3\u3001GSDMB\uff09\u3001\u6c17\u9053\u69cb\u9020\u5909\u5316\u95a2\u9023\u907a\u4f1d\u5b50\uff08ADAM33\uff09\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u9632\u5fa1\u907a\u4f1d\u5b50\uff08GSTP1\uff09\u306a\u3069\u3001\u6a5f\u80fd\u7684\u306b\u591a\u69d8\u306a\u8907\u6570\u306eSNP\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3068\u304f\u306bGSDMB\u3084ORMDL3\u304c\u5b58\u5728\u3059\u308b17\u756a\u67d3\u8272\u4f53q12-21.2\u9818\u57df\u306f\u3001\u5598\u606f\u5168\u4f53\u306e\u611f\u53d7\u6027\u9818\u57df\u3068\u3057\u3066\u6700\u3082\u4e00\u8cab\u3057\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u3066\u304a\u308a\u3001\u56fd\u969b\u7684\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/4421293_s.jpg\" alt=\"\u547c\u5438\" class=\"wp-image-13619\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4421293_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/4421293_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u672c\u89e3\u6790\u306b\u3088\u308a\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3001\u30b2\u30ce\u30e0\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u5598\u606f\u8a3a\u7642\uff08\u500b\u5225\u5316\u533b\u7642\uff09\u306e\u53ef\u80fd\u6027\u3092\u5f37\u304f\u793a\u5506\u3057\u3001\u4eca\u5f8c\u306f\u907a\u4f1d\u5b50\u578b\u306b\u57fa\u3065\u304f\u30ea\u30b9\u30af\u8a55\u4fa1\u3084\u85ac\u5264\u9078\u629e\u304c\u81e8\u5e8a\u5b9f\u8df5\u306e\u4e00\u90e8\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30ad\u30fc\u30ef\u30fc\u30c9\uff5cKeywords<\/strong><\/h2>\n\n\n\n<p class=\"has-text-align-center\"><sup>ADAM33, GSDMB, GSTP1, IL-13, IL-4, IL-4R\u03b1, ORMDL3, SNP, \u4e00\u5869\u57fa\u591a\u578b, \u907a\u4f1d\u5b50\u591a\u578b, \u30a2\u30b9\u30d4\u30ea\u30f3\u904e\u654f\u5598\u606f, \u30a2\u30c8\u30d4\u30fc\u578b\u5598\u606f, \u5598\u606f\u8868\u73fe\u578b, \u91cd\u75c7\u5ea6, \u767a\u75c7\u611f\u53d7\u6027, \u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc, \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u533b\u7642, \u6c17\u7ba1\u652f\u5598\u606f, Aspirin-intolerant asthma, Atopic asthma, Asthma, Biomarker, Genetic polymorphism, Phenotype, Precision medicine, Severity, Susceptibility<\/sup><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2025\/04\/22837143_s.jpg\" alt=\"\u9178\u7d20\u3060\u3041\" class=\"wp-image-13626\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22837143_s.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/04\/22837143_s-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n<div style=\"height:17px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u7528\u6587\u732e\uff5cReferences<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.cyto.2012.05.006\">Liu, S., Li, T., &amp; Liu, J. (2012). Interleukin-4 rs2243250 polymorphism is associated with asthma among Caucasians and related to atopic asthma.\u00a0<em>Cytokine<\/em>,\u00a0<em>59<\/em>(2), 364\u2013369. https:\/\/doi.org\/10.1016\/j.cyto.2012.05.006<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.4103\/1817-1737.128849\">Al-Muhsen, S., Vazquez-Tello, A., Alzaabi, A., Al-Hajjaj, M. S., Al-Jahdali, H. H., &amp; Halwani, R. (2014). IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population.\u00a0<em>Annals of thoracic medicine<\/em>,\u00a0<em>9<\/em>(2), 81\u201386. https:\/\/doi.org\/10.4103\/1817-1737.128849<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.5415\/apallergy.0000000000000119\">Gaceja, K. V., Ancheta, Z. F. R., Buna, A. C. A., Clarencio, S. M. S., Garrido, M. A. R., &amp; Ramos, J. D. A. (2023). Association of interleukin-13 gene single nucleotide polymorphism rs1800925 with allergic asthma in Asian population: A meta-analysis.\u00a0<em>Asia Pacific allergy<\/em>,\u00a0<em>13<\/em>(4), 148\u2013157. https:\/\/doi.org\/10.5415\/apallergy.0000000000000119<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1177\/0300060520929179\">Liu, L., Yue, D., Hu, L., Wang, F., Huang, Y., &amp; Liao, Y. (2020). Relationship between interleukin-13 rs20541 single nucleotide polymorphisms and therapeutic efficacy in children with asthma.\u00a0<em>The Journal of international medical research<\/em>,\u00a0<em>48<\/em>(6), 300060520929179. https:\/\/doi.org\/10.1177\/0300060520929179<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1007\/s10038-006-0081-6\">Sakagami, T., Jinnai, N., Nakajima, T.\u00a0<em>et al.<\/em>\u00a0<em>ADAM33\u00a0<\/em>polymorphisms are associated with aspirin-intolerant asthma in the Japanese population.\u00a0<em>J Hum Genet<\/em>\u00a0<strong>52<\/strong>, 66\u201372 (2007). https:\/\/doi.org\/10.1007\/s10038-006-0081-6<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1164\/rccm.200711-1644OC\">Galanter, J., Choudhry, S., Eng, C., Nazario, S., Rodr\u00edguez-Santana, J. R., Casal, J., Torres-Palacios, A., Salas, J., Chapela, R., Watson, H. G., Meade, K., LeNoir, M., Rodr\u00edguez-Cintr\u00f3n, W., Avila, P. C., &amp; Burchard, E. G. (2008). ORMDL3 gene is associated with asthma in three ethnically diverse populations.\u00a0<em>American journal of respiratory and critical care medicine<\/em>,\u00a0<em>177<\/em>(11), 1194\u20131200. https:\/\/doi.org\/10.1164\/rccm.200711-1644OC<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.jaci.2020.07.030\">Li, X., Christenson, S. A., Modena, B., Li, H., Busse, W. W., Castro, M., Denlinger, L. C., Erzurum, S. C., Fahy, J. V., Gaston, B., Hastie, A. T., Israel, E., Jarjour, N. N., Levy, B. D., Moore, W. C., Woodruff, P. G., Kaminski, N., Wenzel, S. E., Bleecker, E. R., Meyers, D. A., \u2026 NHLBI Severe Asthma Research Program (SARP) (2021). Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways.\u00a0<em>The Journal of allergy and clinical immunology<\/em>,\u00a0<em>147<\/em>(3), 894\u2013909. https:\/\/doi.org\/10.1016\/j.jaci.2020.07.030<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1164\/ajrccm.161.5.9903006\">Fryer, A. A., Bianco, A., Hepple, M., Jones, P. W., Strange, R. C., &amp; Spiteri, M. A. (2000). Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma.\u00a0<em>American journal of respiratory and critical care medicine<\/em>,\u00a0<em>161<\/em>(5), 1437\u20131442. https:\/\/doi.org\/10.1164\/ajrccm.161.5.9903006<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae1010\">The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E. H., Bye-A-Jee, H., Carpentier, D., Denny, P., Fan, J., Garmiri, P., Gonzales, L. J. D. C., Hussein, A., Ignatchenko, A., Insana, G., Ishtiaq, R., Joshi, V., \u2026 Zhang, J. (2025). Uniprot: The universal protein knowledgebase in 2025.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>53<\/em>(D1), D609\u2013D617. https:\/\/doi.org\/10.1093\/nar\/gkae1010<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-021-03819-2\">Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., \u017d\u00eddek, A., Potapenko, A., Bridgland, A., Meyer, C., Kohl, S. A. A., Ballard, A. J., Cowie, A., Romera-Paredes, B., Nikolov, S., Jain, R., Adler, J., \u2026 Hassabis, D. (2021). Highly accurate protein structure prediction with AlphaFold.&nbsp;<em>Nature<\/em>,&nbsp;<em>596<\/em>(7873), 583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1011\">Varadi, M., Bertoni, D., Magana, P., Paramval, U., Pidruchna, I., Radhakrishnan, M., Tsenkov, M., Nair, S., Mirdita, M., Yeo, J., Kovalevskiy, O., Tunyasuvunakool, K., Laydon, A., \u017d\u00eddek, A., Tomlinson, H., Hariharan, D., Abrahamson, J., Green, T., Jumper, J., \u2026 Velankar, S. (2024). AlphaFold Protein Structure Database in 2024: Providing structure coverage for over 214 million protein sequences.&nbsp;<em>Nucleic Acids Research<\/em>,&nbsp;<em>52<\/em>(D1), D368\u2013D375. https:\/\/doi.org\/10.1093\/nar\/gkad1011<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1126\/science.adg7492\">Cheng, J., Novati, G., Pan, J., Bycroft, C., \u017demgulyt\u0117, A., Applebaum, T., Pritzel, A., Wong, L. H., Zielinski, M., Sargeant, T., Schneider, R. G., Senior, A. W., Jumper, J., Hassabis, D., Kohli, P., &amp; Avsec, \u017d. (2023). Accurate proteome-wide missense variant effect prediction with AlphaMissense.&nbsp;<em>Science<\/em>,&nbsp;<em>381<\/em>(6664), eadg7492. https:\/\/doi.org\/10.1126\/science.adg7492<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkae974\">Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., &amp; Haeussler, M. (2025). The UCSC Genome Browser database: 2025 update.&nbsp;<em>Nucleic acids research<\/em>,&nbsp;<em>53<\/em>(D1), D1243\u2013D1249. https:\/\/doi.org\/10.1093\/nar\/gkae974<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad1049\">Harrison, P. W., Amode, M. R., Austine-Orimoloye, O., Azov, A. G., Barba, M., Barnes, I., Becker, A., Bennett, R., Berry, A., Bhai, J., Bhurji, S. K., Boddu, S., Branco\u00a0Lins, P. R., Brooks, L., Ramaraju, S. B., Campbell, L. I., Martinez, M. C., Charkhchi, M., Chougule, K., \u2026 Yates, A. D. (2024). Ensembl 2024.\u00a0<em>Nucleic Acids Research<\/em>,\u00a0<em>52<\/em>(D1), D891\u2013D899. https:\/\/doi.org\/10.1093\/nar\/gkad1049<\/a><\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80cc\u666f\uff5cBackground \u6c17\u7ba1\u652f\u5598\u606f\uff08\u4ee5\u4e0b\u3001\u5598\u606f\uff09\u306f\u3001\u6c17\u9053\u306e\u6162\u6027\u708e\u75c7\u3092\u7279\u5fb4\u3068\u3059\u308b\u75be\u60a3\u3067\u3042\u308a\u3001\u6c17\u6d41\u5236\u9650\u306e\u53ef\u9006\u6027\u3001\u6c17\u9053\u904e\u654f\u6027\uff08bronchial hyperresponsiveness\uff1aBHR\uff09\u3001\u304a\u3088\u3073\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u4f34 [&hellip;]<\/p>\n","protected":false},"author":59,"featured_media":13483,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,237],"tags":[539,550,543,544,548,552,547,242,536,537,549,541,481,225,41,535,540,538,542,546,545,551,337,84],"class_list":["post-13475","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology","category-paper","tag-adam33","tag-gsdmb","tag-gstp1","tag-il-13","tag-il-4","tag-il-4r","tag-ormdl3","tag-snp","tag-536","tag-537","tag-549","tag-541","tag-481","tag-225","tag-personalized-medicine","tag-535","tag-540","tag-538","tag-542","tag-546","tag-545","tag-551","tag-337","tag-84"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/13475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=13475"}],"version-history":[{"count":6,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/13475\/revisions"}],"predecessor-version":[{"id":13633,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/13475\/revisions\/13633"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/13483"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=13475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=13475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=13475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}