{"id":1390,"date":"2025-01-08T02:08:50","date_gmt":"2025-01-08T02:08:50","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=1390"},"modified":"2025-01-30T03:06:22","modified_gmt":"2025-01-30T03:06:22","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%9d%a1%e7%9c%a0%e3%81%ae%e8%b3%aa%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e5%9b%a0%e3%81%8c%e5%bd%b1%e9%9f%bf%e3%81%99%e3%82%8b%e7%90%86%e7%94%b1","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e3%81%a8%e7%9d%a1%e7%9c%a0%e3%81%ae%e8%b3%aa%ef%bc%9a%e9%81%ba%e4%bc%9d%e7%9a%84%e8%a6%81%e5%9b%a0%e3%81%8c%e5%bd%b1%e9%9f%bf%e3%81%99%e3%82%8b%e7%90%86%e7%94%b1\/","title":{"rendered":"\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u8cea\uff1a\u907a\u4f1d\u7684\u8981\u56e0\u304c\u5f71\u97ff\u3059\u308b\u7406\u7531"},"content":{"rendered":"\n<p>\u7761\u7720\u306f\u3001\u79c1\u305f\u3061\u306e\u8eab\u4f53\u3084\u5fc3\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u6b20\u304b\u305b\u306a\u3044\u751f\u7406\u73fe\u8c61\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u7761\u7720\u306e\u8cea\u3084\u30d1\u30bf\u30fc\u30f3\u306b\u306f\u5927\u304d\u306a\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u305d\u306e\u80cc\u666f\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u7761\u7720\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u306a\u907a\u4f1d\u5b50\u3084\u305d\u306e\u50cd\u304d\u3001\u3055\u3089\u306b\u306f\u74b0\u5883\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u6700\u65b0\u306e\u77e5\u898b\u3092\u3082\u3068\u306b\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u7761\u7720\u30d1\u30bf\u30fc\u30f3\u306e\u907a\u4f1d\u7387<\/strong><\/h4>\n\n\n\n<p>\u53cc\u751f\u5150\u7814\u7a76\u306a\u3069\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001<strong>\u7761\u7720\u306e\u8cea\u3084\u30d1\u30bf\u30fc\u30f3\u306b\u306f\u907a\u4f1d\u7684\u306a\u5f71\u97ff\u304c40%\u304b\u308950%\u7a0b\u5ea6\u5b58\u5728\u3059\u308b<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/nrn\">\u53c2\u8003\uff1aNature Reviews Neuroscience<\/a>\uff09\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5bb6\u65cf\u5185\u3067\u4f3c\u305f\u3088\u3046\u306a\u7761\u7720\u7fd2\u6163\u304c\u898b\u3089\u308c\u308b\u5834\u5408\u3001\u305d\u308c\u304c\u5358\u306a\u308b\u751f\u6d3b\u7fd2\u6163\u306b\u3088\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7279\u306b\u3001\u4ee5\u4e0b\u306e\u7761\u7720\u7279\u6027\u306f\u907a\u4f1d\u306e\u5f71\u97ff\u3092\u5f37\u304f\u53d7\u3051\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7761\u7720\u306e\u30bf\u30a4\u30df\u30f3\u30b0\uff08\u671d\u578b\u30fb\u591c\u578b\u306e\u50be\u5411\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u7761\u7720\u6642\u9593\u306e\u9577\u3055<\/strong><\/li>\n\n\n\n<li><strong>\u7761\u7720\u306e\u6df1\u3055\uff08\u30ce\u30f3\u30ec\u30e0\u7761\u7720\u3068\u30ec\u30e0\u7761\u7720\u306e\u5272\u5408\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u7761\u7720\u306b\u95a2\u9023\u3059\u308b\u4e3b\u306a\u907a\u4f1d\u5b50<\/strong><\/h4>\n\n\n\n<p>\u7761\u7720\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306f\u8907\u6570\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001\u7279\u306b\u6ce8\u76ee\u3055\u308c\u308b\u306e\u304c\u4ee5\u4e0b\u306e\u907a\u4f1d\u5b50\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PER\uff08Period\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>PER\u907a\u4f1d\u5b50\u306f\u3001\u4f53\u5185\u6642\u8a08\u3092\u8abf\u6574\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001<strong>\u671d\u578b\u30fb\u591c\u578b\u3068\u3044\u3063\u305f\u7761\u7720\u306e\u30af\u30ed\u30ce\u30bf\u30a4\u30d7<\/strong>\uff08\u6642\u9593\u7684\u50be\u5411\uff09\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7279\u306b\u3001PER3\u907a\u4f1d\u5b50\u306e\u9577\u3044\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u671d\u578b\u50be\u5411\u304c\u5f37\u304f\u3001\u77ed\u3044\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u591c\u578b\u50be\u5411\u304c\u5f37\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\uff1aCurrent Biology\uff09\u3002<\/li>\n\n\n\n<li><strong>CLOCK\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>CLOCK\u907a\u4f1d\u5b50\u3082\u3001\u4f53\u5185\u6642\u8a08\u306e\u30ea\u30ba\u30e0\u3092\u5f62\u6210\u3059\u308b\u4e2d\u5fc3\u7684\u306a\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001<strong>\u7761\u7720\u4e0d\u8db3\u3084\u4e0d\u7720\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027<\/strong>\u304c\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001CLOCK\u907a\u4f1d\u5b50\u306f\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u3084\u4ee3\u8b1d\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\u3001\u7761\u7720\u306e\u8cea\u3068\u7dcf\u5408\u7684\u306a\u5065\u5eb7\u72b6\u614b\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>ADA\uff08\u30a2\u30c7\u30ce\u30b7\u30f3\u30c7\u30a2\u30df\u30ca\u30fc\u30bc\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>\u30a2\u30c7\u30ce\u30b7\u30f3\u306f\u3001\u7720\u6c17\u3092\u5f15\u304d\u8d77\u3053\u3059\u7269\u8cea\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002ADA\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u7761\u7720\u5727\uff08\u7720\u6c17\u306e\u5f37\u3055\uff09\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001<strong>\u65e5\u4e2d\u306e\u75b2\u52b4\u611f\u3084\u899a\u9192\u72b6\u614b\u306e\u6301\u7d9a\u6642\u9593<\/strong>\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>BMAL1\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>BMAL1\u306f\u3001CLOCK\u907a\u4f1d\u5b50\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u4f53\u5185\u6642\u8a08\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u3001<strong>\u4f53\u5185\u6642\u8a08\u306e\u30ea\u30ba\u30e0\u304c\u5d29\u308c\u3084\u3059\u304f\u306a\u308a\u3001\u7761\u7720\u969c\u5bb3\u304c\u767a\u751f\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/strong>\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u306e\u8cea\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u3068\u74b0\u5883\u306e\u30d0\u30e9\u30f3\u30b9<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u304c\u7761\u7720\u306e\u8cea\u3084\u30d1\u30bf\u30fc\u30f3\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306f\u78ba\u304b\u306b\u5927\u304d\u3044\u3082\u306e\u306e\u3001\u305d\u308c\u3060\u3051\u304c\u5168\u3066\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u74b0\u5883\u8981\u56e0\uff08\u5149\u3001\u97f3\u3001\u6e29\u5ea6\u3001\u751f\u6d3b\u7fd2\u6163\u306a\u3069\uff09\u304c\u907a\u4f1d\u7684\u8981\u56e0\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5b9f\u969b\u306e\u7761\u7720\u306e\u8cea\u304c\u6c7a\u307e\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001PER\u907a\u4f1d\u5b50\u3084CLOCK\u907a\u4f1d\u5b50\u304c\u671d\u578b\u306e\u50be\u5411\u3092\u793a\u3057\u3066\u3044\u308b\u4eba\u3067\u3082\u3001\u591c\u9045\u304f\u307e\u3067\u306e\u30c7\u30b8\u30bf\u30eb\u6a5f\u5668\u306e\u4f7f\u7528\u3084\u4e0d\u898f\u5247\u306a\u751f\u6d3b\u30ea\u30ba\u30e0\u306b\u3088\u3063\u3066\u3001<strong>\u672c\u6765\u306e\u4f53\u5185\u30ea\u30ba\u30e0\u304c\u5d29\u308c\u308b\u3053\u3068\u304c\u3042\u308b<\/strong>\u306e\u3067\u3059\uff08\u53c2\u8003\uff1aJournal of Clinical Sleep Medicine\uff09\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u5f79\u5272<\/strong><\/h4>\n\n\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u306f\u3001DNA\u914d\u5217\u81ea\u4f53\u306f\u5909\u308f\u3089\u306a\u3044\u3082\u306e\u306e\u3001\u74b0\u5883\u8981\u56e0\u306b\u3088\u3063\u3066\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u304c\u30aa\u30f3\u30fb\u30aa\u30d5\u3055\u308c\u308b\u4ed5\u7d44\u307f\u306e\u3053\u3068\u3092\u6307\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u3084\u7761\u7720\u4e0d\u8db3\u306f\u3001<strong>\u4f53\u5185\u6642\u8a08\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u3092\u5909\u5316\u3055\u305b\u3001\u9577\u671f\u7684\u306a\u7761\u7720\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059<\/strong>\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/articles\/ncomms\">\u53c2\u8003\uff1aNature Communications<\/a>\uff09\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u304c\u5f71\u97ff\u3059\u308b\u7761\u7720\u969c\u5bb3\u306e\u7a2e\u985e<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/3589543_m-1024x683.jpg\" alt=\"\u6b20\u4f38\u3092\u3059\u308b\u5973\u6027\" class=\"wp-image-3256\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/3589543_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/3589543_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/3589543_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/3589543_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/3589543_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u7684\u8981\u56e0\u306f\u3001\u7279\u5b9a\u306e\u7761\u7720\u969c\u5bb3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u4ee5\u4e0b\u306f\u3001\u4e3b\u306b\u907a\u4f1d\u7684\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u3068\u3055\u308c\u308b\u7761\u7720\u969c\u5bb3\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u6982\u65e5\u30ea\u30ba\u30e0\u7761\u7720\u969c\u5bb3\uff08Circadian Rhythm Sleep Disorders\uff09<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9045\u5ef6\u7761\u7720\u76f8\u969c\u5bb3\uff08DSPS\uff09<\/strong>\uff1a\u591c\u578b\u50be\u5411\u304c\u6975\u7aef\u306b\u5f37\u304f\u3001\u65e9\u5bdd\u65e9\u8d77\u304d\u304c\u56f0\u96e3\u306b\u306a\u308b\u72b6\u614b\u3067\u3059\u3002PER3\u3084CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u524d\u9032\u7761\u7720\u76f8\u969c\u5bb3\uff08ASPS\uff09<\/strong>\uff1a\u9006\u306b\u3001\u6975\u7aef\u306a\u671d\u578b\u50be\u5411\u304c\u5f37\u307e\u308a\u3001\u65e9\u3044\u6642\u9593\u306b\u7720\u6c17\u304c\u8a2a\u308c\u308b\u72b6\u614b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u4e0d\u7720\u75c7\uff08Insomnia\uff09<\/strong><\/h4>\n\n\n\n<p>\u4e0d\u7720\u75c7\u306f\u3001<strong>\u30b9\u30c8\u30ec\u30b9\u3084\u74b0\u5883\u8981\u56e0\u3068\u907a\u4f1d\u7684\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u767a\u75c7<\/strong>\u3057\u307e\u3059\u3002\u7814\u7a76\u3067\u306f\u3001CLOCK\u907a\u4f1d\u5b50\u3084SLC6A4\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff09\u306e\u591a\u578b\u304c\u4e0d\u7720\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.sleepmedrev.com\/\">\u53c2\u8003\uff1aSleep Medicine Reviews<\/a>\uff09\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u904e\u7720\u75c7\uff08\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306a\u3069\uff09<\/strong><\/h4>\n\n\n\n<p>\u904e\u7720\u75c7\u306f\u3001HLA-DQB1\u907a\u4f1d\u5b50\u304c\u767a\u75c7\u30ea\u30b9\u30af\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u81ea\u5df1\u514d\u75ab\u53cd\u5fdc\u304c\u7761\u7720\u899a\u9192\u30b7\u30b9\u30c6\u30e0\u3092\u4e71\u3059\u539f\u56e0\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u306e\u8cea\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u7684\u50be\u5411\u3092\u7406\u89e3\u3059\u308b<\/strong><\/h4>\n\n\n\n<p>\u81ea\u8eab\u306e\u7761\u7720\u50be\u5411\u3092\u77e5\u308b\u305f\u3081\u306b\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u304c\u6709\u52b9\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u671d\u578b\u30fb\u591c\u578b\u306e\u50be\u5411\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u6d3b\u30ea\u30ba\u30e0\u3092\u9069\u5207\u306b\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u74b0\u5883\u8981\u56e0\u3092\u6700\u9069\u5316\u3059\u308b<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5149\u74b0\u5883\u306e\u8abf\u6574<\/strong>\uff1a\u663c\u9593\u306f\u81ea\u7136\u5149\u3092\u6d74\u3073\u3001\u591c\u306f\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3092\u907f\u3051\u308b\u3053\u3068\u3067\u4f53\u5185\u6642\u8a08\u3092\u5b89\u5b9a\u3055\u305b\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong>\uff1a\u7761\u7720\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\uff08\u4f8b\uff1aBDNF\uff09\u306e\u767a\u73fe\u3092\u4fc3\u3059\u305f\u3081\u306b\u3001\u30e8\u30ac\u3084\u7791\u60f3\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6d3b\u7528<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30e1\u30e9\u30c8\u30cb\u30f3\u3084\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u306e\u6442\u53d6\u304c\u3001\u7761\u7720\u306e\u8cea\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Current Biology \u2013 PER\u907a\u4f1d\u5b50\u3068\u7761\u7720\u30d1\u30bf\u30fc\u30f3<\/li>\n\n\n\n<li>Journal of Clinical Sleep Medicine \u2013 \u907a\u4f1d\u5b50\u3068\u74b0\u5883\u306e\u76f8\u4e92\u4f5c\u7528<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/ncomms\">Nature Communications \u2013 \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u7761\u7720\u969c\u5bb3<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sleepmedrev.com\/\">Sleep Medicine Reviews \u2013 \u907a\u4f1d\u5b50\u3068\u4e0d\u7720\u75c7<\/a><\/li>\n<\/ol>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u3068\u907a\u4f1d\u5b50\u306e\u6df1\u3044\u95a2\u4fc2\uff1a\u6700\u65b0\u7814\u7a76\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/h3>\n\n\n\n<p>\u7761\u7720\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u306f\u8fd1\u5e74\u6025\u901f\u306b\u9032\u5c55\u3057\u3066\u304a\u308a\u3001\u79c1\u305f\u3061\u306e\u4f53\u5185\u6642\u8a08\u3084\u7761\u7720\u969c\u5bb3\u306e\u539f\u56e0\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u77e5\u898b\u304c\u6b21\u3005\u3068\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u57fa\u306b\u3001\u4eca\u5f8c\u306f\u3088\u308a\u500b\u5225\u5316\u3055\u308c\u305f\u7761\u7720\u6539\u5584\u306e\u65b9\u6cd5\u3084\u6cbb\u7642\u6cd5\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u7761\u7720\u3068\u907a\u4f1d\u5b50\u306b\u95a2\u3059\u308b\u6700\u65b0\u7814\u7a76\u3084\u5b9f\u7528\u5316\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u6df1\u6398\u308a\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u3088\u308b\u65b0\u305f\u306a\u767a\u898b<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/908323_m-1024x768.jpg\" alt=\"\u8155\u6642\u8a08\u3068\u7a7a\n\" class=\"wp-image-3263\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/908323_m-1024x768.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/908323_m-300x225.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/908323_m-768x576.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/908323_m-1536x1152.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/908323_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u4f53\u5185\u6642\u8a08\u3068\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u8abf\u6574<\/strong><\/h4>\n\n\n\n<p>\u4f53\u5185\u6642\u8a08\uff08\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\uff09\u3092\u8abf\u6574\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001<strong>PER\u907a\u4f1d\u5b50\u3084CLOCK\u907a\u4f1d\u5b50<\/strong>\u3092\u4e2d\u5fc3\u306b\u8a73\u7d30\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u6700\u65b0\u7814\u7a76\u3067\u306f\u3055\u3089\u306b\u8907\u96d1\u306a\u8abf\u6574\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRY\uff08Cryptochrome\uff09\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>PER\u907a\u4f1d\u5b50\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308bCRY\u907a\u4f1d\u5b50\u304c\u3001\u7761\u7720\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3084\u6df1\u3055\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u3046\u307e\u304f\u50cd\u304b\u306a\u3044\u5834\u5408\u3001<strong>\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u4ee3\u8b1d\u3084\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u306b\u3082\u60aa\u5f71\u97ff<\/strong>\u304c\u53ca\u3076\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>NPAS2\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>CLOCK\u907a\u4f1d\u5b50\u3068\u4f3c\u305f\u5f79\u5272\u3092\u6301\u3064NPAS2\u907a\u4f1d\u5b50\u306f\u3001\u4e3b\u306b\u8133\u306e\u795e\u7d4c\u6d3b\u52d5\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001<strong>\u7761\u7720\u4e2d\u306e\u8a18\u61b6\u306e\u6574\u7406\u3084\u8133\u306e\u4fee\u5fa9<\/strong>\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u7761\u7720\u4e0d\u8db3\u304c\u8a8d\u77e5\u6a5f\u80fd\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u5927\u304d\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.jneurosci.org\/\">\u53c2\u8003\uff1aJournal of Neuroscience<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u7761\u7720\u306e\u907a\u4f1d\u7684\u591a\u69d8\u6027\u3068\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2<\/strong><\/h4>\n\n\n\n<p>\u7761\u7720\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306f1\u3064\u3060\u3051\u3067\u306f\u306a\u304f\u3001<strong>\u8907\u6570\u306e\u907a\u4f1d\u5b50\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u7761\u7720\u306e\u8cea\u304c\u6c7a\u307e\u308b<\/strong>\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u300c\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u300d\u3068\u547c\u3073\u3001\u500b\u3005\u4eba\u306e\u7761\u7720\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u7761\u7720\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u65b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4f8b\u3048\u3070\u3001\u4e0d\u7720\u75c7\u306b\u5bfe\u3057\u3066\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306f\u3001\u7761\u7720\u5c0e\u5165\u5264\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u8abf\u6574\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/ng\">\u53c2\u8003\uff1aNature Genetics<\/a>\uff09\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u3068\u7cbe\u795e\u7684\u5065\u5eb7\u306e\u3064\u306a\u304c\u308a\uff1a\u907a\u4f1d\u5b50\u306e\u5f79\u5272<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u7761\u7720\u4e0d\u8db3\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u95a2\u4fc2<\/strong><\/h4>\n\n\n\n<p>\u7761\u7720\u4e0d\u8db3\u304c\u3046\u3064\u75c5\u3001\u4e0d\u5b89\u969c\u5bb3\u3001\u53cc\u6975\u6027\u969c\u5bb3\u306a\u3069\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001**SLC6A4\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\uff09<strong>\u3084<\/strong>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09**\u304c\u7761\u7720\u3068\u7cbe\u795e\u7684\u5065\u5eb7\u306e\u4e21\u65b9\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>SLC6A4\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong>\uff1a\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u518d\u53d6\u308a\u8fbc\u307f\u304c\u3046\u307e\u304f\u8abf\u7bc0\u3055\u308c\u305a\u3001\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u4e0d\u5b89\u3084\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/mp\">\u53c2\u8003\uff1aMolecular Psychiatry<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>BDNF\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u76f8\u4e92\u4f5c\u7528<\/strong>\uff1aBDNF\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u7761\u7720\u4e2d\u306e\u8133\u306e\u56de\u5fa9\u304c\u4e0d\u5341\u5206\u3068\u306a\u308a\u3001\u6c17\u5206\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u7761\u7720\u4e0d\u8db3\u304c\u5f15\u304d\u8d77\u3053\u3059\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316<\/strong><\/h4>\n\n\n\n<p>\u6162\u6027\u7684\u306a\u7761\u7720\u4e0d\u8db3\u306f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u7cbe\u795e\u7684\u5065\u5eb7\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PER2\u907a\u4f1d\u5b50\u306e\u30e1\u30c1\u30eb\u5316<\/strong>\uff1a\u4f53\u5185\u6642\u8a08\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u30b9\u30a4\u30c3\u30c1\u304c\u5909\u5316\u3057\u3001\u663c\u591c\u9006\u8ee2\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>\u708e\u75c7\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5897\u52a0<\/strong>\uff1a\u7761\u7720\u4e0d\u8db3\u304c\u514d\u75ab\u7cfb\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u6162\u6027\u7684\u306a\u708e\u75c7\u72b6\u614b\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u5909\u5316\u306f\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3084\u4ecb\u5165\u306b\u3088\u3063\u3066\u3042\u308b\u7a0b\u5ea6\u30ea\u30d0\u30fc\u30b7\u30d6\u30eb\u3067\u3042\u308b\u305f\u3081\u3001\u65e9\u671f\u306e\u4ecb\u5165\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7761\u7720\u6539\u5584\u306e\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/24926082_m-1024x683.jpg\" alt=\"\u30d9\u30c3\u30c9\u3067\u8d77\u304d\u308b\u5973\u6027\" class=\"wp-image-3270\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/24926082_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/24926082_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/24926082_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/24926082_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/24926082_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6280\u8853\u304c\u9032\u6b69\u3057\u305f\u3053\u3068\u306b\u3088\u308a\u3001\u81ea\u8eab\u306e\u907a\u4f1d\u7684\u306a\u7761\u7720\u50be\u5411\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u7761\u7720\u6539\u5584\u7b56\u3092\u500b\u5225\u5316\u3057\u3066\u5b9f\u8df5\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u7761\u7720\u6539\u5584\u7b56<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u305f\u7d50\u679c\u306b\u57fa\u3065\u304d\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u63d0\u6848\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u671d\u578b\u30fb\u591c\u578b\u306e\u50be\u5411\u3092\u77e5\u308b<\/strong>\uff1aPER3\u907a\u4f1d\u5b50\u3084CLOCK\u907a\u4f1d\u5b50\u306e\u7d50\u679c\u306b\u57fa\u3065\u304d\u3001\u81ea\u5206\u306b\u9069\u3057\u305f\u5c31\u5bdd\u6642\u9593\u3084\u6d3b\u52d5\u6642\u9593\u3092\u8a2d\u5b9a\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u85ac\u7269\u7642\u6cd5\u306e\u6700\u9069\u5316<\/strong>\uff1a\u4f8b\u3048\u3070\u3001ADA\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306b\u306f\u3001\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u6442\u53d6\u3092\u63a7\u3048\u308b\u30a2\u30c9\u30d0\u30a4\u30b9\u304c\u9069\u7528\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u30c7\u30b8\u30bf\u30eb\u30d8\u30eb\u30b9\u3068\u306e\u878d\u5408<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u30a2\u30d7\u30ea\u3084\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u304c\u767b\u5834\u3057\u3066\u304a\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30b5\u30fc\u30d3\u30b9\u304c\u5229\u7528\u53ef\u80fd\u3067\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7761\u7720\u30c7\u30fc\u30bf\u3068\u907a\u4f1d\u60c5\u5831\u3092\u7d71\u5408\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30b3\u30fc\u30c1\u30f3\u30b0<\/strong><\/li>\n\n\n\n<li><strong>\u4f53\u5185\u6642\u8a08\u306b\u57fa\u3065\u3044\u305f\u30a2\u30e9\u30fc\u30e0\u8a2d\u5b9a<\/strong>\uff08\u8d77\u5e8a\u30bf\u30a4\u30df\u30f3\u30b0\u306e\u6700\u9069\u5316\uff09<\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u3084\u74b0\u5883\u8981\u56e0\u306e\u5f71\u97ff\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u8a55\u4fa1<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u3053\u3046\u3057\u305f\u6280\u8853\u306f\u3001\u5f93\u6765\u306e\u300c\u5168\u3066\u306e\u4eba\u306b\u9069\u7528\u3055\u308c\u308b\u300d\u7761\u7720\u6539\u5584\u6cd5\u304b\u3089\u3001<strong>\u500b\u3005\u306e\u30cb\u30fc\u30ba\u306b\u5fdc\u3058\u305f\u500b\u5225\u5316\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong>\u3078\u306e\u8ee2\u63db\u3092\u4fc3\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u3068\u907a\u4f1d\u5b50\u306e\u672a\u6765\uff1a\u6b21\u4e16\u4ee3\u533b\u7642\u3078\u306e\u671f\u5f85<\/strong><\/h3>\n\n\n\n<p>\u7761\u7720\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u7814\u7a76\u306f\u3001\u4eca\u5f8c\u3055\u3089\u306b\u9032\u5c55\u3057\u3001<strong>\u4e88\u9632\u533b\u5b66\u3084\u5148\u7aef\u533b\u7642\u306e\u5206\u91ce\u3067\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3059<\/strong>\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR\uff09<\/strong>\uff1a\u7761\u7720\u969c\u5bb3\u306e\u6839\u672c\u539f\u56e0\u3067\u3042\u308b\u907a\u4f1d\u5b50\u306e\u4fee\u6b63\u304c\u53ef\u80fd\u306b\u306a\u308b\u672a\u6765\u304c\u898b\u3048\u3066\u3044\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u7279\u5b9a<\/strong>\uff1a\u7761\u7720\u4e0d\u8db3\u3084\u4e0d\u7720\u75c7\u306e\u521d\u671f\u5146\u5019\u3092\u65e9\u671f\u306b\u691c\u51fa\u3067\u304d\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>AI\u306b\u3088\u308b\u8a3a\u65ad\u306e\u7cbe\u5bc6\u5316<\/strong>\uff1aAI\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u89e3\u6790\u306b\u3088\u308a\u3001\u7761\u7720\u969c\u5bb3\u306e\u8a3a\u65ad\u7cbe\u5ea6\u304c\u5411\u4e0a\u3057\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u63d0\u6848\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u9032\u6b69\u306b\u3088\u308a\u3001<strong>\u4e00\u4eba\u3072\u3068\u308a\u306b\u9069\u3057\u305f\u7761\u7720\u6539\u5584\u6cd5\u3084\u6cbb\u7642\u6cd5\u304c\u63d0\u4f9b\u3055\u308c\u308b\u672a\u6765<\/strong>\u304c\u73fe\u5b9f\u306e\u3082\u306e\u3068\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.jneurosci.org\/\">Journal of Neuroscience \u2013 NPAS2\u907a\u4f1d\u5b50\u3068\u8133\u6a5f\u80fd<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/ng\">Nature Genetics \u2013 \u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3068\u7761\u7720<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/mp\">Molecular Psychiatry \u2013 SLC6A4\u907a\u4f1d\u5b50\u3068\u3046\u3064\u75c5\u30ea\u30b9\u30af<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/13652869\">Journal of Sleep Research \u2013 \u7761\u7720\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2<\/a><\/li>\n<\/ol>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u3068\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u5fdc\u7528\u4e8b\u4f8b\uff1a\u65e5\u5e38\u751f\u6d3b\u3078\u306e\u5f71\u97ff<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/30157583_m-1024x683.jpg\" alt=\"\u671d\u306b\u6c34\u3092\u98f2\u3080\u5973\u6027\" class=\"wp-image-3277\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30157583_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30157583_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30157583_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30157583_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30157583_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306b\u95a2\u3059\u308b\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u79d1\u5b66\u7684\u77e5\u8b58\u304c\u5b9f\u969b\u306e\u751f\u6d3b\u3084\u5065\u5eb7\u7ba1\u7406\u306b\u3069\u306e\u3088\u3046\u306b\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3001\u5177\u4f53\u7684\u306a\u4e8b\u4f8b\u304c\u5897\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u53d6\u308a\u7d44\u307f\u306f\u3001\u500b\u4eba\u306e\u7761\u7720\u3092\u6539\u5584\u3057\u3001\u65e5\u5e38\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u6700\u9069\u5316\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u793e\u4f1a\u5168\u4f53\u306e\u751f\u7523\u6027\u5411\u4e0a\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7761\u7720\u8a08\u753b\u306e\u5c0e\u5165<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u57fa\u306b\u3057\u305f\u7761\u7720\u7fd2\u6163\u306e\u6700\u9069\u5316<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u30b5\u30fc\u30d3\u30b9\u3092\u63d0\u4f9b\u3059\u308b\u4f01\u696d\u304c\u5897\u3048\u3001\u81ea\u5206\u81ea\u8eab\u306e\u7761\u7720\u306b\u95a2\u3059\u308b\u907a\u4f1d\u7684\u50be\u5411\u3092\u628a\u63e1\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u7761\u7720\u8a08\u753b\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PER3\u907a\u4f1d\u5b50\u3092\u57fa\u306b\u3057\u305f\u5c31\u5bdd\u6642\u9593\u306e\u8abf\u6574<\/strong><strong><br><\/strong>PER3\u907a\u4f1d\u5b50\u304c\u77ed\u3044\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u591c\u578b\u50be\u5411\u306e\u4eba\u306b\u306f\u3001\u81ea\u7136\u306a\u4f53\u5185\u6642\u8a08\u306b\u6cbf\u3063\u305f\u9045\u3044\u52e4\u52d9\u6642\u9593\u3084\u30d5\u30ec\u30c3\u30af\u30b9\u30bf\u30a4\u30e0\u304c\u63a8\u5968\u3055\u308c\u308b\u30b1\u30fc\u30b9\u304c\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u671d\u578b\u306e\u907a\u4f1d\u5b50\u50be\u5411\u3092\u6301\u3064\u4eba\u306f\u3001\u65e9\u3044\u6642\u9593\u5e2f\u306e\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u304c\u6700\u3082\u52b9\u7387\u7684\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>ADA\u907a\u4f1d\u5b50\u306b\u3088\u308b\u30ab\u30d5\u30a7\u30a4\u30f3\u6442\u53d6\u306e\u7ba1\u7406<\/strong><strong><br><\/strong>\u30ab\u30d5\u30a7\u30a4\u30f3\u611f\u53d7\u6027\u304c\u9ad8\u3044\u4eba\u306f\u3001\u591c\u9593\u306e\u899a\u9192\u72b6\u614b\u304c\u7d9a\u304d\u3084\u3059\u3044\u305f\u3081\u3001\u5348\u5f8c\u4ee5\u964d\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u6442\u53d6\u3092\u63a7\u3048\u308b\u3053\u3068\u3067\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u74b0\u5883\u5149\u3068\u4f53\u5185\u6642\u8a08\u306e\u8abf\u6574<\/strong><strong><br><\/strong>CLOCK\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u5834\u5408\u3001\u671d\u306e\u81ea\u7136\u5149\u3092\u591a\u304f\u6d74\u3073\u308b\u3053\u3068\u3067\u4f53\u5185\u30ea\u30ba\u30e0\u3092\u30ea\u30bb\u30c3\u30c8\u3057\u3084\u3059\u304f\u306a\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3092\u5fdc\u7528\u3057\u3066\u3001\u30b9\u30de\u30fc\u30c8\u7167\u660e\u3084\u30bf\u30a4\u30de\u30fc\u4ed8\u304d\u306e\u5149\u7642\u6cd5\u30c7\u30d0\u30a4\u30b9\u3092\u4f7f\u7528\u3059\u308b\u30b1\u30fc\u30b9\u3082\u5897\u3048\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u7761\u7720\u969c\u5bb3\u306e\u4e88\u9632\u3068\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u4e0d\u7720\u75c7\u306e\u65e9\u671f\u767a\u898b<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u628a\u63e1\u3059\u308b\u3053\u3068\u3067\u3001\u4e0d\u7720\u75c7\u306a\u3069\u306e\u7761\u7720\u969c\u5bb3\u3092\u65e9\u671f\u306b\u767a\u898b\u3057\u3001\u4e88\u9632\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u53d6\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/strong><strong><br><\/strong>CLOCK\u3084PER\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u591a\u578b\u3092\u6301\u3064\u4eba\u304c\u3001\u4e0d\u7720\u75c7\u3084\u6982\u65e5\u30ea\u30ba\u30e0\u7761\u7720\u969c\u5bb3\u3092\u767a\u75c7\u3057\u3084\u3059\u3044\u30ea\u30b9\u30af\u3092\u691c\u77e5\u3057\u3001\u65e9\u3044\u6bb5\u968e\u3067\u751f\u6d3b\u7fd2\u6163\u3084\u533b\u7642\u7684\u4ecb\u5165\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\uff08<a href=\"https:\/\/www.sleepmedrev.com\/\">\u53c2\u8003\uff1aSleep Medicine Reviews<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u6cbb\u7642\u6cd5\u306e\u500b\u5225\u5316<\/strong><strong><br><\/strong>\u7761\u7720\u85ac\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306f\u3001\u907a\u4f1d\u7684\u306a\u4ee3\u8b1d\u80fd\u529b\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002CYP2D6\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u4eba\u306f\u3001\u4e00\u822c\u7684\u306a\u7761\u7720\u85ac\u306e\u52b9\u679c\u304c\u51fa\u306b\u304f\u3044\u5834\u5408\u304c\u3042\u308b\u305f\u3081\u3001\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u6700\u9069\u306a\u85ac\u5264\u3092\u9078\u3076\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7761\u7720\u969c\u5bb3\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6cd5<\/strong><\/h4>\n\n\n\n<p>\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3084\u795e\u7d4c\u8abf\u7bc0\u7642\u6cd5\u3092\u6d3b\u7528\u3057\u305f\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR\u306b\u3088\u308b\u907a\u4f1d\u5b50\u4fee\u6b63<\/strong><strong><br><\/strong>\u7761\u7720\u969c\u5bb3\u306e\u6839\u672c\u7684\u306a\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u4fee\u6b63\u3059\u308b\u8a66\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u6982\u65e5\u30ea\u30ba\u30e0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308bPER2\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u7570\u5e38\u306a\u4f53\u5185\u6642\u8a08\u3092\u6b63\u5e38\u5316\u3059\u308b\u6cbb\u7642\u304c\u958b\u767a\u4e2d\u3067\u3059\u3002<\/li>\n\n\n\n<li><strong>\u975e\u4fb5\u8972\u7684\u306a\u795e\u7d4c\u523a\u6fc0\u7642\u6cd5<\/strong><strong><br><\/strong>\u7761\u7720\u306b\u95a2\u9023\u3059\u308b\u8133\u306e\u7279\u5b9a\u90e8\u4f4d\u3092\u523a\u6fc0\u3057\u3001\u81ea\u7136\u306a\u7761\u7720\u30ea\u30ba\u30e0\u3092\u56de\u5fa9\u3055\u305b\u308b\u6280\u8853\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3067\u7761\u7720\u306b\u8ab2\u984c\u3092\u62b1\u3048\u308b\u60a3\u8005\u306b\u7279\u306b\u6709\u52b9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u7761\u7720\u3068\u50cd\u304d\u65b9\u6539\u9769\uff1a\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u8077\u5834\u74b0\u5883\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u7761\u7720\u306e\u8cea\u306f\u3001\u4ed5\u4e8b\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3084\u751f\u7523\u6027\u306b\u76f4\u7d50\u3057\u307e\u3059\u3002\u907a\u4f1d\u7684\u306a\u7761\u7720\u50be\u5411\u3092\u6d3b\u7528\u3057\u3001\u50cd\u304d\u65b9\u3092\u6539\u5584\u3059\u308b\u4f01\u696d\u306e\u53d6\u308a\u7d44\u307f\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u304f\u52e4\u52d9\u6642\u9593\u306e\u8abf\u6574<\/strong><\/h4>\n\n\n\n<p>\u4f01\u696d\u306f\u5f93\u696d\u54e1\u306e\u907a\u4f1d\u7684\u306a\u7761\u7720\u50be\u5411\u306b\u57fa\u3065\u3044\u3066\u3001\u67d4\u8edf\u306a\u52e4\u52d9\u6642\u9593\u3092\u8a2d\u3051\u308b\u53d6\u308a\u7d44\u307f\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u671d\u578b\u306e\u5f93\u696d\u54e1<\/strong>\u306b\u306f\u3001\u65e9\u671d\u306e\u4f1a\u8b70\u3084\u91cd\u8981\u306a\u30bf\u30b9\u30af\u3092\u5272\u308a\u5f53\u3066\u308b\u3002<\/li>\n\n\n\n<li><strong>\u591c\u578b\u306e\u5f93\u696d\u54e1<\/strong>\u306b\u306f\u3001\u5348\u5f8c\u3084\u591c\u9593\u306e\u30af\u30ea\u30a8\u30a4\u30c6\u30a3\u30d6\u696d\u52d9\u3092\u62c5\u5f53\u3055\u305b\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u3088\u3046\u306a\u53d6\u308a\u7d44\u307f\u306f\u3001\u793e\u54e1\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u6700\u5927\u5316\u3057\u3001\u8077\u5834\u306e\u6e80\u8db3\u5ea6\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u7761\u7720\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u5065\u5eb7\u7ba1\u7406\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"765\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/30936341_m-1024x765.jpg\" alt=\"\u30b9\u30de\u30db\u3000\u30c7\u30fc\u30bf\" class=\"wp-image-3284\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30936341_m-1024x765.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30936341_m-300x224.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30936341_m-768x574.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30936341_m-1536x1147.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30936341_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3084\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u6d3b\u7528\u3057\u305f\u7761\u7720\u30c8\u30e9\u30c3\u30ad\u30f3\u30b0\u3092\u5c0e\u5165\u3059\u308b\u4f01\u696d\u3082\u5897\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u53d6\u308a\u7d44\u307f\u304c\u5b9f\u73fe\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u63d0\u4f9b<\/strong>\uff1a\u30b9\u30c8\u30ec\u30b9\u3068\u7761\u7720\u306e\u95a2\u4fc2\u3092\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u7167\u3089\u3057\u5408\u308f\u305b\u3001\u9069\u5207\u306a\u30ea\u30e9\u30af\u30bc\u30fc\u30b7\u30e7\u30f3\u6cd5\u3092\u63d0\u4f9b\u3002<\/li>\n\n\n\n<li><strong>\u30b7\u30d5\u30c8\u52e4\u52d9\u8005\u5411\u3051\u30d7\u30e9\u30f3<\/strong>\uff1a\u591c\u52e4\u3092\u4f34\u3046\u8077\u696d\u306e\u5f93\u696d\u54e1\u306b\u5bfe\u3057\u3001\u4f53\u5185\u30ea\u30ba\u30e0\u3092\u5d29\u3055\u306a\u3044\u305f\u3081\u306e\u98df\u4e8b\u30fb\u7761\u7720\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3092\u63d0\u6848\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u7761\u7720\u7814\u7a76\u306e\u672a\u6765\u3068\u500b\u5225\u5316\u533b\u7642<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b66\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u7761\u7720\u306b\u95a2\u9023\u3059\u308b\u7814\u7a76\u306f\u6b21\u306e\u30b9\u30c6\u30fc\u30b8\u3078\u3068\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5206\u91ce\u304c\u4eca\u5f8c\u6ce8\u76ee\u3055\u308c\u308b\u3067\u3057\u3087\u3046\uff1a<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u500b\u5225\u5316\u533b\u7642\u306e\u6df1\u5316<\/strong><\/h4>\n\n\n\n<p>AI\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u89e3\u6790\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u6cd5\u3084\u4e88\u9632\u6cd5\u304c\u3088\u308a\u6b63\u78ba\u306b\u63d0\u4f9b\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AI\u304c\u5c0e\u304f\u8a3a\u65ad\u7cbe\u5ea6\u306e\u5411\u4e0a<\/strong>\uff1aAI\u3092\u7528\u3044\u3066\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u7761\u7720\u969c\u5bb3\u306e\u65e9\u671f\u767a\u898b\u3092\u5b9f\u73fe\u3002<\/li>\n\n\n\n<li><strong>\u65b0\u85ac\u958b\u767a\u3078\u306e\u5fdc\u7528<\/strong>\uff1a\u7761\u7720\u969c\u5bb3\u306e\u907a\u4f1d\u7684\u539f\u56e0\u3092\u6a19\u7684\u306b\u3057\u305f\u85ac\u5264\u306e\u958b\u767a\u304c\u9032\u884c\u4e2d\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u65b0\u3057\u3044\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3078\u306e\u63d0\u6848<\/strong><\/h4>\n\n\n\n<p>\u672a\u6765\u306e\u7761\u7720\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u300c\u7406\u60f3\u7684\u306a1\u65e5\u306e\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u300d\u306e\u63d0\u6848\u304c\u53ef\u80fd\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u3053\u308c\u306b\u306f\u3001<strong>\u500b\u3005\u306e\u4f53\u5185\u6642\u8a08\u306b\u5408\u308f\u305b\u305f\u8d77\u5e8a\u30fb\u98df\u4e8b\u30fb\u904b\u52d5\u30fb\u5c31\u5bdd\u306e\u6642\u9593\u8a2d\u5b9a<\/strong>\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.jneurosci.org\/\">Journal of Neuroscience \u2013 CRY\u907a\u4f1d\u5b50\u3068\u7761\u7720\u306e\u6df1\u3055<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/ng\">Nature Genetics \u2013 \u907a\u4f1d\u5b50\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u7761\u7720\u969c\u5bb3<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sleepmedrev.com\/\">Sleep Medicine Reviews \u2013 \u907a\u4f1d\u5b50\u3068\u4e0d\u7720\u75c7\u6cbb\u7642<\/a><\/li>\n\n\n\n<li>Journal of Clinical Sleep Medicine \u2013 \u7761\u7720\u6539\u5584\u306e\u305f\u3081\u306e\u74b0\u5883\u8abf\u6574<\/li>\n<\/ol>\n\n\n\n<p><span id=\"docs-internal-guid-48d79815-7fff-fece-f2d7-10cad1e82f92\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u306e\u8cea\u3068\u907a\u4f1d\u5b50\u306e\u3055\u3089\u306a\u308b\u53ef\u80fd\u6027<\/strong><\/h3>\n\n\n\n<p>\u7761\u7720\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u907a\u4f1d\u5b50\u3068\u751f\u6d3b\u7fd2\u6163\u304c\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u57fa\u306b\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u3084\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u6539\u5584\u7b56\u304c\u63d0\u6848\u3055\u308c\u308b\u4e00\u65b9\u3067\u3001\u7761\u7720\u7814\u7a76\u306f\u793e\u4f1a\u5168\u4f53\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u3067\u306f\u3001\u7761\u7720\u3068\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u672a\u6765\u306b\u304a\u3051\u308b\u5c55\u671b\u306b\u3064\u3044\u3066\u6398\u308a\u4e0b\u3052\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u6b21\u4e16\u4ee3\u306e\u7761\u7720\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/27608292_m-1024x574.jpg\" alt=\"\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\" class=\"wp-image-3291\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/27608292_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/27608292_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/27608292_m-768x430.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/27608292_m-1536x861.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/27608292_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u3055\u308c\u305f\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u6280\u8853<\/strong><\/h4>\n\n\n\n<p>\u7761\u7720\u30c7\u30fc\u30bf\u3092\u30c8\u30e9\u30c3\u30ad\u30f3\u30b0\u3059\u308b\u30c7\u30d0\u30a4\u30b9\u304c\u9032\u5316\u3092\u9042\u3052\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u6027\u3092\u8003\u616e\u3057\u305f\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u6280\u8853\u304c\u5c0e\u5165\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30b5\u30fc\u30d3\u30b9\u304c\u73fe\u5b9f\u5316\u3057\u3066\u3044\u307e\u3059\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u500b\u5225\u5316\u3055\u308c\u305f\u30a2\u30e9\u30fc\u30e0\u30b7\u30b9\u30c6\u30e0<\/strong>\uff1a\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3001\u7761\u7720\u30b5\u30a4\u30af\u30eb\u306b\u6700\u9069\u306a\u8d77\u5e8a\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u901a\u77e5\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u3068\u74b0\u5883\u8981\u56e0\u306e\u7d71\u5408\u5206\u6790<\/strong>\uff1a\u4f53\u6e29\u3001\u5fc3\u62cd\u6570\u3001\u5149\u74b0\u5883\u306a\u3069\u306e\u30c7\u30fc\u30bf\u3092\u907a\u4f1d\u5b50\u60c5\u5831\u3068\u7d44\u307f\u5408\u308f\u305b\u3001\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u63d0\u6848\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u63d0\u4f9b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306e\u7761\u7720\u30c7\u30fc\u30bf\u89e3\u6790<\/strong><\/h4>\n\n\n\n<p>AI\u304c\u7761\u7720\u4e2d\u306b\u5f97\u3089\u308c\u308b\u30c7\u30fc\u30bf\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u89e3\u6790\u3057\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u5bfe\u5fdc\u3092\u5373\u5ea7\u306b\u30a2\u30c9\u30d0\u30a4\u30b9\u3059\u308b\u4ed5\u7d44\u307f\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001<strong>\u591c\u9593\u306e\u7761\u7720\u4e2d\u65ad\u304c\u5897\u3048\u308b\u539f\u56e0\u304c\u907a\u4f1d\u5b50\u7531\u6765\u304b\u74b0\u5883\u7531\u6765\u304b\u3092\u898b\u5206\u3051\u3001\u9069\u5207\u306a\u5bfe\u7b56\u3092\u63d0\u6848<\/strong>\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u7761\u7720\u7814\u7a76\u306e\u793e\u4f1a\u7684\u30a4\u30f3\u30d1\u30af\u30c8<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u9ad8\u9f62\u8005\u306e\u7761\u7720\u6539\u5584\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong><\/h4>\n\n\n\n<p>\u9ad8\u9f62\u8005\u306f\u3001\u52a0\u9f62\u306b\u4f34\u3044\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u554f\u984c\u306b\u5bfe\u3057\u3001<strong>\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8a55\u4fa1\u3068\u751f\u6d3b\u7fd2\u6163\u306e\u6307\u5c0e\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u4ecb\u5165\u30d7\u30ed\u30b0\u30e9\u30e0<\/strong>\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>BMAL1\u907a\u4f1d\u5b50\u306e\u6d3b\u52d5\u4f4e\u4e0b\u304c\u7761\u7720\u306e\u5206\u65ad\u3092\u5f15\u304d\u8d77\u3053\u3059<\/strong>\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f\u7761\u7720\u7642\u6cd5\u306e\u958b\u767a\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u6559\u80b2\u73fe\u5834\u3078\u306e\u5fdc\u7528<\/strong><\/h4>\n\n\n\n<p>\u5b66\u6821\u3084\u6559\u80b2\u6a5f\u95a2\u3067\u3082\u3001\u907a\u4f1d\u7684\u306a\u7761\u7720\u30d1\u30bf\u30fc\u30f3\u3092\u8003\u616e\u3057\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u5c0e\u5165\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001<strong>\u6210\u9577\u671f\u306e\u5b50\u3069\u3082\u305f\u3061\u306e\u7761\u7720\u3092\u652f\u63f4\u3059\u308b\u305f\u3081\u3001\u907a\u4f1d\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u6700\u9069\u306a\u5b66\u7fd2\u30fb\u7761\u7720\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb<\/strong>\u306e\u4f5c\u6210\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u8077\u5834\u74b0\u5883\u306e\u9032\u5316<\/strong><\/h4>\n\n\n\n<p>\u4f01\u696d\u3084\u7d44\u7e54\u306f\u3001\u793e\u54e1\u306e\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u751f\u7523\u6027\u3092\u9ad8\u3081\u308b\u53d6\u308a\u7d44\u307f\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u7684\u306b\u591c\u578b\u50be\u5411\u3092\u6301\u3064\u793e\u54e1\u306b\u30d5\u30ec\u30c3\u30af\u30b9\u30bf\u30a4\u30e0\u3092\u5c0e\u5165\u3059\u308b\u306a\u3069\u3001<strong>\u50cd\u304d\u65b9\u6539\u9769\u3068\u7761\u7720\u6539\u5584\u3092\u878d\u5408\u3055\u305b\u305f\u53d6\u308a\u7d44\u307f<\/strong>\u304c\u52b4\u50cd\u74b0\u5883\u306e\u65b0\u3057\u3044\u30c8\u30ec\u30f3\u30c9\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Journal of Clinical Sleep Medicine \u2013 \u7761\u7720\u4e2d\u65ad\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u9023<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/neuro\/\">Nature Neuroscience \u2013 BMAL1\u907a\u4f1d\u5b50\u3068\u9ad8\u9f62\u8005\u306e\u7761\u7720<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sleephealthjournal.org\/\">Sleep Health Journal \u2013 \u8077\u5834\u74b0\u5883\u306e\u7761\u7720\u6539\u5584<\/a><\/li>\n<\/ol>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p>\u7761\u7720\u306e\u8cea\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u307e\u3059\u3002\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001PER\u3084CLOCK\u306a\u3069\u306e\u907a\u4f1d\u5b50\u304c\u7761\u7720\u30d1\u30bf\u30fc\u30f3\u3084\u7761\u7720\u969c\u5bb3\u306b\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3001\u500b\u5225\u5316\u3055\u308c\u305f\u7761\u7720\u6539\u5584\u7b56\u3084\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u8077\u5834\u3084\u6559\u80b2\u73fe\u5834\u306a\u3069\u3001\u793e\u4f1a\u5168\u4f53\u306b\u5e83\u304c\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3082\u7761\u7720\u7814\u7a76\u304c\u9032\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u79c1\u305f\u3061\u306e\u5065\u5eb7\u3068\u751f\u6d3b\u306e\u8cea\u304c\u5411\u4e0a\u3059\u308b\u65b0\u305f\u306a\u9053\u304c\u958b\u3051\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7761\u7720\u306f\u3001\u79c1\u305f\u3061\u306e\u8eab\u4f53\u3084\u5fc3\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u6b20\u304b\u305b\u306a\u3044\u751f\u7406\u73fe\u8c61\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u7761\u7720\u306e\u8cea\u3084\u30d1\u30bf\u30fc\u30f3\u306b\u306f\u5927\u304d\u306a\u500b\u4eba\u5dee\u304c\u3042\u308a\u3001\u305d\u306e\u80cc\u666f\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u7761\u7720 [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":1391,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1390","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/1390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=1390"}],"version-history":[{"count":2,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/1390\/revisions"}],"predecessor-version":[{"id":3298,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/1390\/revisions\/3298"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/1391"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=1390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=1390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=1390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}