{"id":1406,"date":"2025-01-08T02:36:12","date_gmt":"2025-01-08T02:36:12","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=1406"},"modified":"2025-01-31T01:51:22","modified_gmt":"2025-01-31T01:51:22","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e7%a0%94%e7%a9%b6%e3%81%8c%e5%a4%89%e3%81%88%e3%82%8b%e6%9c%aa%e6%9d%a5%e3%81%ae%e6%b2%bb%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e7%a0%94%e7%a9%b6%e3%81%8c%e5%a4%89%e3%81%88%e3%82%8b%e6%9c%aa%e6%9d%a5%e3%81%ae%e6%b2%bb%e7%99%82%e6%b3%95\/","title":{"rendered":"\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u5909\u3048\u308b\u672a\u6765\u306e\u6cbb\u7642\u6cd5"},"content":{"rendered":"\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306f\u3001\u533b\u7642\u306e\u3042\u308a\u65b9\u3092\u5927\u304d\u304f\u5909\u3048\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002<strong>\u75c5\u6c17\u306e\u539f\u56e0\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u7279\u5b9a\u3057\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u304b\u3064\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u533b\u7642\u304c\u5b9f\u73fe<\/strong>\u3057\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306e\u9032\u5316\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u666e\u53ca\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u5b9f\u7528\u5316\u306a\u3069\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u3082\u305f\u3089\u3059\u5909\u9769\u306f\u591a\u5c90\u306b\u308f\u305f\u308a\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001<strong>\u6700\u65b0\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u3068\u672a\u6765\u306e\u6cbb\u7642\u6cd5\u306b\u95a2\u3059\u308b\u6700\u65b0\u77e5\u898b<\/strong>\u3092\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><span id=\"docs-internal-guid-9c414180-7fff-63ac-a5ae-65d8732ba87a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u3068\u533b\u7642\u3078\u306e\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1-1. \u30d2\u30c8\u30b2\u30ce\u30e0\u89e3\u6790\u306e\u9032\u5316<\/strong><\/h4>\n\n\n\n<p>2003\u5e74\u306e\u30d2\u30c8\u30b2\u30ce\u30e0\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u5b8c\u4e86\u4ee5\u964d\u3001DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u306f\u98db\u8e8d\u7684\u306b\u9032\u6b69\u3057\u307e\u3057\u305f\u3002\u73fe\u5728\u3067\u306f\u3001<strong>\u6570\u767e\u30c9\u30eb\u7a0b\u5ea6\u3067\u500b\u4eba\u306e\u5168\u30b2\u30ce\u30e0\u3092\u89e3\u6790\u3067\u304d\u308b<\/strong>\u3088\u3046\u306b\u306a\u308a\u3001\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u533b\u7642\u304c\u8eab\u8fd1\u306a\u3082\u306e\u306b\u306a\u3063\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.nature.com\/nrg\/\">\u53c2\u8003\uff1aNature Reviews Genetics<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08NGS\uff09\u6280\u8853<\/strong>\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u907a\u4f1d\u75be\u60a3\u306e\u8a3a\u65ad\u3084\u304c\u3093\u306e\u907a\u4f1d\u5b50\u5909\u7570\u89e3\u6790\u304c\u8fc5\u901f\u306b\u884c\u3048\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002<\/li>\n\n\n\n<li>**\u5168\u30b2\u30ce\u30e0\u89e3\u6790\uff08WGS\uff09\u3084\u5168\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\uff08WES\uff09**\u306b\u3088\u3063\u3066\u3001\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u6cbb\u7642\u6cd5\u3092\u500b\u5225\u5316\u3059\u308b\u8a66\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1-2. \u907a\u4f1d\u5b50\u3068\u75be\u60a3\u306e\u95a2\u9023\u6027\u306e\u89e3\u660e<\/strong><\/h4>\n\n\n\n<p>\u591a\u304f\u306e\u75be\u60a3\u306b\u306f\u907a\u4f1d\u7684\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u3092\u901a\u3058\u3066\u3001\u7279\u5b9a\u306e\u75c5\u6c17\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u5909\u7570\u304c\u6b21\u3005\u3068\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068APOE\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>APOE4\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001<strong>\u4e88\u9632\u7684\u4ecb\u5165\u3084\u65e9\u671f\u8a3a\u65ad\u306b\u6d3b\u7528\u3055\u308c\u3066\u3044\u308b<\/strong>\uff08<a href=\"https:\/\/www.j-alz.com\/\">\u53c2\u8003\uff1aJournal of Alzheimer&#8217;s Disease<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u304c\u3093\u3068BRCA\u907a\u4f1d\u5b50<\/strong><strong><br><\/strong>BRCA1\/2\u306e\u5909\u7570\u306f\u4e73\u304c\u3093\u30fb\u5375\u5de3\u304c\u3093\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u305f\u3081\u3001<strong>\u4e88\u9632\u7684\u624b\u8853\u3084\u6a19\u7684\u6cbb\u7642\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u3063\u3066\u3044\u308b\uff08<a href=\"https:\/\/www.nejm.org\/\">\u53c2\u8003\uff1aNew England Journal of Medicine<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-9c414180-7fff-63ac-a5ae-65d8732ba87a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u6cbb\u7642\u306e\u9032\u5316<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2-1. CRISPR-Cas9\u306b\u3088\u308b\u907a\u4f1d\u5b50\u7de8\u96c6<\/strong><\/h4>\n\n\n\n<p>CRISPR-Cas9\u6280\u8853\u306e\u767b\u5834\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u90e8\u4f4d\u3092\u6b63\u78ba\u306b\u6539\u5909\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u6280\u8853\u306f\u3001<strong>\u907a\u4f1d\u6027\u75be\u60a3\u306e\u6cbb\u7642\u3084\u304c\u3093\u6cbb\u7642\u306a\u3069\u306b\u5fdc\u7528\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059<\/strong>\uff08<a href=\"https:\/\/www.science.org\/\">\u53c2\u8003\uff1aScience<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u938c\u72b6\u8d64\u8840\u7403\u75c7\uff08SCD\uff09\u3068\u03b2\u30b5\u30e9\u30bb\u30df\u30a2\u306e\u6cbb\u7642<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u3063\u3066\u3001\u8d64\u8840\u7403\u306e\u7570\u5e38\u306a\u5f62\u72b6\u3092\u4fee\u6b63\u3057\u3001<strong>\u6b63\u5e38\u306a\u8840\u6db2\u7d30\u80de\u306e\u751f\u6210\u3092\u4fc3\u3059\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u4e2d<\/strong>\uff08<a href=\"https:\/\/www.nature.com\/nm\/\">\u53c2\u8003\uff1aNature Medicine<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u5f37\u5316<\/strong><strong><br><\/strong>T\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3057\u3001**\u3088\u308a\u52b9\u679c\u7684\u306a\u304c\u3093\u514d\u75ab\u7642\u6cd5\uff08CAR-T\u7d30\u80de\u7642\u6cd5\uff09**\u3092\u5b9f\u73fe\u3002CRISPR\u306b\u3088\u3063\u3066\u3001\u304c\u3093\u7d30\u80de\u3092\u653b\u6483\u3059\u308b\u80fd\u529b\u3092\u5f37\u5316\u3057\u305fT\u7d30\u80de\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2-2. \u30d9\u30fc\u30b9\u30a8\u30c7\u30a3\u30c6\u30a3\u30f3\u30b0\u3068\u30d7\u30e9\u30a4\u30e0\u30a8\u30c7\u30a3\u30c6\u30a3\u30f3\u30b0<\/strong><\/h4>\n\n\n\n<p>CRISPR-Cas9\u3088\u308a\u3082\u6b63\u78ba\u306b\u907a\u4f1d\u5b50\u3092\u7de8\u96c6\u3067\u304d\u308b\u6280\u8853\u3068\u3057\u3066\u3001<strong>\u30d9\u30fc\u30b9\u30a8\u30c7\u30a3\u30c6\u30a3\u30f3\u30b0\uff08\u5869\u57fa\u7de8\u96c6\uff09\u3068\u30d7\u30e9\u30a4\u30e0\u30a8\u30c7\u30a3\u30c6\u30a3\u30f3\u30b0\uff08\u9ad8\u5ea6\u7de8\u96c6\u6280\u8853\uff09\u304c\u767b\u5834<\/strong>\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d9\u30fc\u30b9\u30a8\u30c7\u30a3\u30c6\u30a3\u30f3\u30b0\uff1aDNA\u306e\u4e00\u672c\u9396\u3092\u4fee\u6b63\u3057\u3001<strong>\u7279\u5b9a\u306e\u5869\u57fa\u306e\u7f6e\u63db\u3092\u6b63\u78ba\u306b\u884c\u3046<\/strong>\u3002<\/li>\n\n\n\n<li>\u30d7\u30e9\u30a4\u30e0\u30a8\u30c7\u30a3\u30c6\u30a3\u30f3\u30b0\uff1aDNA\u306e\u5869\u57fa\u914d\u5217\u3092\u6539\u5909\u3057\u3001<strong>\u7a81\u7136\u5909\u7570\u306b\u3088\u308b\u907a\u4f1d\u75c5\u306e\u6cbb\u7642\u306b\u5fdc\u7528<\/strong>\u3055\u308c\u3064\u3064\u3042\u308b\uff08<a href=\"https:\/\/www.nature.com\/\">\u53c2\u8003\uff1aNature<\/a>\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-9c414180-7fff-63ac-a5ae-65d8732ba87a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u81e8\u5e8a\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/30663698_m-1024x683.jpg\" alt=\"\u81ea\u5206\u306e\u76ee\u3092\u93e1\u3067\u898b\u308b\u7537\u6027\" class=\"wp-image-3372\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30663698_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30663698_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30663698_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30663698_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30663698_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3-1. \u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u6210\u529f\u4e8b\u4f8b<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u6cbb\u7642\u306f\u3001<strong>\u907a\u4f1d\u6027\u75be\u60a3\u3084\u304c\u3093\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u5fdc\u7528<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\uff08SMA\uff09\u3068Zolgensma<\/strong><strong><br><\/strong>SMA\u306fSMN1\u907a\u4f1d\u5b50\u306e\u6b20\u640d\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u96e3\u75c5\u3060\u304c\u3001<strong>\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u88dc\u5145\u7642\u6cd5\u306b\u3088\u308a\u3001\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f<\/strong>\uff08\u53c2\u8003\uff1aLancet Neurology\uff09\u3002<\/li>\n\n\n\n<li><strong>\u7db2\u819c\u8272\u7d20\u5909\u6027\u75c7\u306e\u907a\u4f1d\u5b50\u6cbb\u7642<\/strong><strong><br><\/strong>RPE65\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u907a\u4f1d\u5b50\u6cbb\u7642\u85ac\u300c\u30eb\u30af\u30b9\u30bf\u30fc\u30ca\u300d\u306f\u3001\u8996\u899a\u3092\u56de\u5fa9\u3055\u305b\u308b\u753b\u671f\u7684\u306a\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3-2. \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30b8\u30fc\u30f3\u30bb\u30e9\u30d4\u30fc<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u6cbb\u7642\u306f\u3001\u60a3\u8005\u3054\u3068\u306b\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u3059\u308b\u300c\u500b\u5225\u5316\u533b\u7642\u300d\u3078\u3068\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002<strong>\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u6cbb\u7642\u85ac\u304c\u958b\u767a\u3055\u308c\u3064\u3064\u3042\u308a\u3001\u7cbe\u5bc6\u533b\u7642\u306e\u672a\u6765\u304c\u5e83\u304c\u3063\u3066\u3044\u308b<\/strong>\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u533b\u7642<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>4-1. \u907a\u4f1d\u5b50\u8a3a\u65ad\u3068\u4e88\u9632\u533b\u5b66<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u57fa\u3065\u304d\u3001<strong>\u75c5\u6c17\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u3001\u4e88\u9632\u7684\u306a\u6cbb\u7642\u3092\u884c\u3046<\/strong>\u53d6\u308a\u7d44\u307f\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d5\u30a1\u30fc\u30de\u30b3\u30b2\u30ce\u30df\u30af\u30b9\uff08\u85ac\u7406\u30b2\u30ce\u30df\u30af\u30b9\uff09<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001<strong>\u500b\u3005\u306e\u60a3\u8005\u306b\u6700\u9069\u306a\u85ac\u5264\u3084\u6295\u4e0e\u91cf\u3092\u6c7a\u5b9a\u3059\u308b\u6280\u8853<\/strong>\u304c\u78ba\u7acb\u3055\u308c\u3064\u3064\u3042\u308b\uff08<a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/\">\u53c2\u8003\uff1aClinical Pharmacology &amp; Therapeutics<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u65e9\u671f\u8a3a\u65ad<\/strong><strong><br><\/strong>APOE\u907a\u4f1d\u5b50\u5909\u7570\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001<strong>\u5c06\u6765\u7684\u306a\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3057\u3001\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u8a08\u3059\u308b\u8a66\u307f<\/strong>\u304c\u9032\u3093\u3067\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>4-2. \u907a\u4f1d\u5b50\u30d9\u30fc\u30b9\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u6539\u5584<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6804\u990a\u3068\u907a\u4f1d\u5b50\uff08\u30cb\u30e5\u30fc\u30c8\u30ea\u30b2\u30ce\u30df\u30af\u30b9\uff09<\/strong><strong><br><\/strong>\u907a\u4f1d\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3001<strong>\u6700\u9069\u306a\u98df\u4e8b\u30d7\u30e9\u30f3\u3084\u6804\u990a\u7d20\u3092\u500b\u5225\u306b\u8abf\u6574<\/strong>\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><strong>\u904b\u52d5\u3068\u907a\u4f1d\u5b50\uff08\u30a8\u30af\u30b5\u30b5\u30a4\u30ba\u30fb\u30b2\u30ce\u30df\u30af\u30b9\uff09<\/strong><strong><br><\/strong>\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u3066\u3001<strong>\u500b\u4eba\u306e\u4f53\u8cea\u306b\u5408\u3063\u305f\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u8a08\u3059\u308b\u8a66\u307f\u304c\u9032\u884c\u4e2d<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/nrg\/\">Nature Reviews Genetics \u2013 \u30b2\u30ce\u30e0\u89e3\u6790\u3068\u533b\u7642<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.science.org\/\">Science \u2013 CRISPR\u3068\u907a\u4f1d\u5b50\u7de8\u96c6<\/a><\/li>\n\n\n\n<li>Lancet Neurology \u2013 SMA\u306e\u907a\u4f1d\u5b50\u6cbb\u7642<\/li>\n\n\n\n<li><a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/\">Clinical Pharmacology &amp; Therapeutics \u2013 \u30d5\u30a1\u30fc\u30de\u30b3\u30b2\u30ce\u30df\u30af\u30b9<\/a><\/li>\n<\/ol>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u6700\u524d\u7dda\u3068\u672a\u6765\u306e\u53ef\u80fd\u6027<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u6cbb\u7642\u306f\u3001\u5f93\u6765\u306e\u6cbb\u7642\u6cd5\u3067\u306f\u6cbb\u7652\u304c\u96e3\u3057\u3044\u75be\u60a3\u306b\u5bfe\u3059\u308b\u753b\u671f\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u6025\u901f\u306b\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001<strong>\u907a\u4f1d\u5b50\u306e\u6b20\u640d\u3084\u5909\u7570\u304c\u539f\u56e0\u3068\u306a\u308b\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u304c\u5b9f\u7528\u5316<\/strong>\u3055\u308c\u3064\u3064\u3042\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u591a\u304f\u306e\u75c5\u6c17\u306b\u9069\u7528\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5-1. \u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u9769\u65b0\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>5-1-1. \u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3092\u5229\u7528\u3057\u305f\u907a\u4f1d\u5b50\u5c0e\u5165<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"771\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/31799250_m-1024x771.jpg\" alt=\"\u30a6\u30a4\u30eb\u30b9\" class=\"wp-image-3379\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31799250_m-1024x771.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31799250_m-300x226.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31799250_m-768x578.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31799250_m-1536x1157.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31799250_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u591a\u304f\u306f\u3001<strong>\u30a6\u30a4\u30eb\u30b9\u3092\u904b\u3073\u5c4b\uff08\u30d9\u30af\u30bf\u30fc\uff09\u3068\u3057\u3066\u7528\u3044\u3001\u6cbb\u7642\u907a\u4f1d\u5b50\u3092\u4f53\u5185\u306b\u5c0e\u5165<\/strong>\u3059\u308b\u624b\u6cd5\u3092\u63a1\u7528\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\uff08AAV\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u5c0f\u578b\u3067\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3057\u306b\u304f\u3044\u305f\u3081\u3001<strong>\u5b89\u5168\u6027\u304c\u9ad8\u3044\u30d9\u30af\u30bf\u30fc<\/strong>\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li>SMA\uff08\u810a\u9ac4\u6027\u7b4b\u840e\u7e2e\u75c7\uff09\u306e\u6cbb\u7642\u85ac\u300c\u30be\u30eb\u30b2\u30f3\u30b9\u30de\uff08Zolgensma\uff09\u300d\u306b\u63a1\u7528\uff08<a href=\"https:\/\/www.nejm.org\/\">\u53c2\u8003\uff1aNew England Journal of Medicine<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9<\/strong>\n<ul class=\"wp-block-list\">\n<li>HIV\u3092\u6539\u5909\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3067\u3001<strong>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3084\u907a\u4f1d\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u6d3b\u7528<\/strong>\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u6cbb\u7642\u7814\u7a76\u304c\u9032\u884c\u4e2d\uff08\u53c2\u8003\uff1aMolecular Therapy\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>5-1-2. \u975e\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3092\u5229\u7528\u3057\u305f\u6cbb\u7642\u6cd5<\/strong><\/h4>\n\n\n\n<p>\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u305a\u306b\u907a\u4f1d\u5b50\u3092\u7d30\u80de\u306b\u5c0e\u5165\u3059\u308b\u65b9\u6cd5\u3082\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u3088\u308a\u5b89\u5168\u306a\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u9078\u629e\u80a2\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30dd\u30bd\u30fc\u30e0\u3084\u30ca\u30ce\u7c92\u5b50\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u5c0e\u5165<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u3092\u5c01\u5165\u3057\u305f\u30ca\u30ce\u7c92\u5b50\u3092\u7d30\u80de\u306b\u9001\u308a\u8fbc\u3080\u3053\u3068\u3067\u3001<strong>\u304c\u3093\u3084\u4ee3\u8b1d\u75be\u60a3\u306e\u6cbb\u7642\u306b\u5fdc\u7528<\/strong>\u3055\u308c\u3066\u3044\u308b\uff08<a href=\"https:\/\/www.nature.com\/nnano\/\">\u53c2\u8003\uff1aNature Nanotechnology<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u96fb\u6c17\u7a7f\u5b54\u6cd5\uff08\u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u819c\u306b\u5fae\u5f31\u306a\u96fb\u6d41\u3092\u6d41\u3057\u3001\u4e00\u6642\u7684\u306b\u958b\u3044\u305f\u7d30\u80de\u819c\u304b\u3089DNA\u3092\u5c0e\u5165\u3059\u308b\u65b9\u6cd5\u3002<\/li>\n\n\n\n<li>CAR-T\u7d30\u80de\u7642\u6cd5\uff08\u304c\u3093\u514d\u75ab\u6cbb\u7642\uff09\u306b\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5-2. \u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u5fdc\u7528\u7bc4\u56f2\u306e\u62e1\u5927<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>5-2-1. \u795e\u7d4c\u75be\u60a3\u3078\u306e\u907a\u4f1d\u5b50\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u306f\u9577\u3089\u304f\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u304c\u9650\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001<strong>\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u9032\u6b69\u306b\u3088\u308a\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u304c\u958b\u767a<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u907a\u4f1d\u5b50\u6cbb\u7642<\/strong>\n<ul class=\"wp-block-list\">\n<li>APOE4\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>BACE1\u963b\u5bb3\u5264\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001<strong>\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u306e\u84c4\u7a4d\u3092\u6291\u3048\u308b\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u4e2d<\/strong>\uff08<a href=\"https:\/\/www.jneurosci.org\/\">\u53c2\u8003\uff1aJournal of Neuroscience<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u907a\u4f1d\u5b50\u6cbb\u7642<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>GDNF\uff08\u30b0\u30ea\u30a2\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u3092\u767a\u73fe\u3055\u305b\u308b\u907a\u4f1d\u5b50\u6cbb\u7642<\/strong>\u304c\u3001\u795e\u7d4c\u7d30\u80de\u306e\u751f\u5b58\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff08\u53c2\u8003\uff1aBrain\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>5-2-2. \u907a\u4f1d\u5b50\u6cbb\u7642\u306b\u3088\u308b\u96e3\u6cbb\u6027\u304c\u3093\u306e\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>\u304c\u3093\u6cbb\u7642\u3067\u306f\u3001<strong>\u6a19\u7684\u907a\u4f1d\u5b50\u3092\u6539\u5909\u3059\u308b\u3053\u3068\u3067\u816b\u760d\u306e\u6210\u9577\u3092\u6291\u5236\u3057\u3001\u514d\u75ab\u7d30\u80de\u306e\u653b\u6483\u529b\u3092\u9ad8\u3081\u308b\u6cbb\u7642\u6cd5\u304c\u6025\u901f\u306b\u9032\u5316<\/strong>\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>p53\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u304c\u3093\u6cbb\u7642<\/strong>\n<ul class=\"wp-block-list\">\n<li>p53\u306f\u300c\u30b2\u30ce\u30e0\u306e\u5b88\u8b77\u8005\u300d\u3068\u3057\u3066\u77e5\u3089\u308c\u3001\u5909\u7570\u3059\u308b\u3068\u304c\u3093\u306e\u767a\u751f\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u3002<\/li>\n\n\n\n<li>CRISPR\u6280\u8853\u3092\u7528\u3044\u3066p53\u3092\u4fee\u5fa9\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u6291\u5236\uff08\u53c2\u8003\uff1aCancer Research\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u500b\u5225\u5316CAR-T\u7d30\u80de\u7642\u6cd5<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u6539\u5909T\u7d30\u80de\uff08CAR-T\u7d30\u80de\uff09\u3092\u7528\u3044\u305f\u6cbb\u7642\u306f\u3001\u8840\u6db2\u304c\u3093\u306b\u5bfe\u3057\u3066\u9ad8\u3044\u52b9\u679c\u3092\u793a\u3059\u3002<\/li>\n\n\n\n<li>\u6700\u8fd1\u3067\u306f<strong>\u56fa\u5f62\u304c\u3093\u306b\u3082\u5fdc\u7528\u3067\u304d\u308b\u65b0\u3057\u3044CAR-T\u7642\u6cd5\u304c\u958b\u767a<\/strong>\u3055\u308c\u3064\u3064\u3042\u308b\uff08\u53c2\u8003\uff1aClinical Cancer Research\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-9c414180-7fff-63ac-a5ae-65d8732ba87a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u4e88\u9632\u533b\u5b66<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31715696_m-1024x683.jpg\" alt=\"\u8a3a\u5bdf\u3059\u308b\u5973\u6027\u533b\u5e2b\" class=\"wp-image-3148\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31715696_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31715696_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31715696_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31715696_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31715696_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>6-1. \u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u75c5\u6c17\u306e\u65e9\u671f\u767a\u898b<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u306e\u9032\u6b69\u306b\u3088\u308a\u3001<strong>\u500b\u4eba\u306e\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u628a\u63e1\u3057\u3001\u65e9\u671f\u306b\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4e73\u304c\u3093\u30fb\u5375\u5de3\u304c\u3093\u306e\u30ea\u30b9\u30af\u8a55\u4fa1\uff08BRCA\u907a\u4f1d\u5b50\uff09<\/strong>\n<ul class=\"wp-block-list\">\n<li>BRCA1\/2\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001\u4e88\u9632\u7684\u624b\u8853\u3084\u53b3\u683c\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u63a8\u5968\u3055\u308c\u308b\uff08\u53c2\u8003\uff1aJAMA Oncology\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u907a\u4f1d\u5b50\u30ea\u30b9\u30af\u30b9\u30b3\u30a2<\/strong>\n<ul class=\"wp-block-list\">\n<li>LDLR\u907a\u4f1d\u5b50\u3084PCSK9\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u5fc3\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3002<\/li>\n\n\n\n<li>\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3084\u3001\u30b9\u30bf\u30c1\u30f3\u306a\u3069\u306e\u85ac\u5264\u306b\u3088\u308b\u4e88\u9632\u304c\u53ef\u80fd\uff08\u53c2\u8003\uff1aCirculation\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>6-2. \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30cb\u30e5\u30fc\u30c8\u30ea\u30b2\u30ce\u30df\u30af\u30b9\uff08\u6804\u990a\u907a\u4f1d\u5b66\uff09<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u6d3b\u7528\u3057\u3001**\u500b\u3005\u306e\u4f53\u8cea\u306b\u9069\u3057\u305f\u98df\u4e8b\u3084\u6804\u990a\u6442\u53d6\u3092\u63d0\u6848\u3059\u308b\u300c\u30cb\u30e5\u30fc\u30c8\u30ea\u30b2\u30ce\u30df\u30af\u30b9\u300d**\u304c\u767a\u5c55\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FTO\u907a\u4f1d\u5b50\u3068\u80a5\u6e80\u30ea\u30b9\u30af<\/strong>\n<ul class=\"wp-block-list\">\n<li>FTO\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u3001\u7cd6\u8cea\u4ee3\u8b1d\u3084\u8102\u80aa\u84c4\u7a4d\u306b\u9055\u3044\u304c\u751f\u3058\u308b\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u578b\u306b\u5fdc\u3058\u3066\u3001<strong>\u4f4e\u70ad\u6c34\u5316\u7269\u98df\u3084\u9ad8\u30bf\u30f3\u30d1\u30af\u98df\u306e\u9069\u5fdc\u3092\u500b\u5225\u5316<\/strong>\uff08\u53c2\u8003\uff1aAmerican Journal of Clinical Nutrition\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>CYP1A2\u907a\u4f1d\u5b50\u3068\u30ab\u30d5\u30a7\u30a4\u30f3\u4ee3\u8b1d<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30ab\u30d5\u30a7\u30a4\u30f3\u306e\u4ee3\u8b1d\u80fd\u529b\u306f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u3001<strong>\u4e00\u90e8\u306e\u4eba\u306f\u30ab\u30d5\u30a7\u30a4\u30f3\u6442\u53d6\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b<\/strong>\u53ef\u80fd\u6027\u304c\u3042\u308b\uff08<a href=\"https:\/\/link.springer.com\/journal\/394\">\u53c2\u8003\uff1aEuropean Journal of Nutrition<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nejm.org\/\">New England Journal of Medicine \u2013 \u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u9032\u5c55<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/nnano\/\">Nature Nanotechnology \u2013 \u30ca\u30ce\u7c92\u5b50\u3092\u6d3b\u7528\u3057\u305f\u907a\u4f1d\u5b50\u5c0e\u5165<\/a><\/li>\n\n\n\n<li>Cancer Research \u2013 p53\u907a\u4f1d\u5b50\u3068\u304c\u3093\u6cbb\u7642<\/li>\n\n\n\n<li>Circulation \u2013 \u907a\u4f1d\u5b50\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af<\/li>\n\n\n\n<li>JAMA Oncology \u2013 BRCA\u907a\u4f1d\u5b50\u3068\u304c\u3093\u30ea\u30b9\u30af<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u7814\u7a76\u304c\u5207\u308a\u958b\u304f\u672a\u6765\u306e\u533b\u7642\u6280\u8853<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001<strong>\u3053\u308c\u307e\u3067\u6cbb\u7642\u304c\u56f0\u96e3\u3060\u3063\u305f\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059<\/strong>\u3002\u304c\u3093\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3001\u611f\u67d3\u75c7\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u5206\u91ce\u3067\u907a\u4f1d\u5b50\u3092\u6d3b\u7528\u3057\u305f\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u3082\u305f\u3089\u3059\u672a\u6765\u306e\u533b\u7642\u6280\u8853\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-1. \u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u5fdc\u7528<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/30532422_m-1024x683.jpg\" alt=\"\u771f\u5263\u306b\u30d1\u30bd\u30b3\u30f3\u3092\u898b\u3066\u3044\u308b\u7537\u6027\n\" class=\"wp-image-3386\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30532422_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30532422_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30532422_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30532422_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/30532422_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u304c\u3093\u306e\u767a\u75c7\u306b\u306f\u907a\u4f1d\u5b50\u5909\u7570\u304c\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001<strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3057\u305f\u500b\u5225\u5316\u6cbb\u7642\u304c\u6025\u901f\u306b\u9032\u3093\u3067\u3044\u307e\u3059<\/strong>\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>7-1-1. \u304c\u3093\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u304c\u3093\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u5b9f\u73fe\u306b\u5411\u3051\u305f\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30cd\u30aa\u30a2\u30f3\u30c1\u30b2\u30f3\u30ef\u30af\u30c1\u30f3<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u60a3\u8005\u306e\u816b\u760d\u7d30\u80de\u304b\u3089\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u89e3\u6790\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u305f\u30ef\u30af\u30c1\u30f3\u3092\u8a2d\u8a08\u3059\u308b\u6280\u8853\u3002<\/li>\n\n\n\n<li>\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3092\u6d3b\u6027\u5316\u3057\u3001<strong>\u304c\u3093\u7d30\u80de\u3092\u7279\u7570\u7684\u306b\u653b\u6483\u3059\u308b<\/strong>\uff08\u53c2\u8003\uff1aCancer Immunology Research\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>mRNA\u30ef\u30af\u30c1\u30f3\u306e\u5fdc\u7528<\/strong>\n<ul class=\"wp-block-list\">\n<li>COVID-19\u30ef\u30af\u30c1\u30f3\u3067\u7528\u3044\u3089\u308c\u305fmRNA\u6280\u8853\u304c\u3001\u304c\u3093\u6cbb\u7642\u306b\u3082\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>\u500b\u3005\u306e\u816b\u760d\u907a\u4f1d\u5b50\u306b\u57fa\u3065\u3044\u305f<strong>\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u304c\u9032\u884c\u4e2d<\/strong>\uff08<a href=\"https:\/\/www.nature.com\/nm\/\">\u53c2\u8003\uff1aNature Medicine<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>7-1-2. AI\u3092\u6d3b\u7528\u3057\u305f\u304c\u3093\u8a3a\u65ad\u3068\u6cbb\u7642<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068AI\u6280\u8853\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u306e\u65e9\u671f\u767a\u898b\u3068\u500b\u5225\u5316\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6a5f\u68b0\u5b66\u7fd2\u306b\u3088\u308b\u304c\u3093\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong>\n<ul class=\"wp-block-list\">\n<li>AI\u304c\u5927\u91cf\u306e\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u3001\u304c\u3093\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u907a\u4f1d\u5b50\u5909\u7570\u3092\u7279\u5b9a\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u7cbe\u5bc6\u533b\u7642\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u60a3\u8005\u3054\u3068\u306b\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u3092\u9078\u629e\u3067\u304d\u308b<\/strong>\uff08<a href=\"https:\/\/www.nature.com\/natmachintell\/\">\u53c2\u8003\uff1aNature Machine Intelligence<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>AI\u306b\u3088\u308b\u5275\u85ac\u306e\u52a0\u901f<\/strong>\n<ul class=\"wp-block-list\">\n<li>AI\u304c\u81a8\u5927\u306a\u5316\u5408\u7269\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3001<strong>\u304c\u3093\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u85ac\u306e\u958b\u767a\u3092\u52a0\u901f<\/strong>\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u5909\u7570\u3054\u3068\u306b\u6700\u9069\u306a\u6cbb\u7642\u85ac\u3092\u7279\u5b9a\u3059\u308b\u6280\u8853\u304c\u9032\u5316\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-9c414180-7fff-63ac-a5ae-65d8732ba87a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-2. \u907a\u4f1d\u5b50\u7de8\u96c6\u3068\u518d\u751f\u533b\u7642<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u518d\u751f\u533b\u7642\u306e\u878d\u5408\u306b\u3088\u308a\u3001\u81d3\u5668\u79fb\u690d\u306e\u4ee3\u66ff\u3084\u3001\u7d44\u7e54\u306e\u4fee\u5fa9\u304c\u53ef\u80fd\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>7-2-1. iPS\u7d30\u80de\u3068\u907a\u4f1d\u5b50\u7de8\u96c6\u306e\u878d\u5408<\/strong><\/h4>\n\n\n\n<p>iPS\u7d30\u80de\uff08\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff09\u6280\u8853\u3068CRISPR\u907a\u4f1d\u5b50\u7de8\u96c6\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001<strong>\u907a\u4f1d\u6027\u75be\u60a3\u306e\u6cbb\u7642\u3084\u81d3\u5668\u518d\u751f\u306e\u53ef\u80fd\u6027\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059<\/strong>\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u6cbb\u7642<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u60a3\u8005\u81ea\u8eab\u306eiPS\u7d30\u80de\u3092\u7528\u3044\u3066\u30c9\u30fc\u30d1\u30df\u30f3\u795e\u7d4c\u7d30\u80de\u3092\u4f5c\u6210\u3057\u3001\u79fb\u690d\u3059\u308b\u7814\u7a76\u304c\u9032\u884c\u4e2d\uff08\u53c2\u8003\uff1aStem Cell Reports\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5fc3\u75be\u60a3\u306e\u518d\u751f\u533b\u7642<\/strong>\n<ul class=\"wp-block-list\">\n<li>iPS\u7d30\u80de\u3092\u6d3b\u7528\u3057\u3066\u5fc3\u7b4b\u7d30\u80de\u3092\u4f5c\u88fd\u3057\u3001\u5fc3\u4e0d\u5168\u60a3\u8005\u306e\u6cbb\u7642\u306b\u5fdc\u7528\u3002<\/li>\n\n\n\n<li><strong>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u60a3\u8005\u3054\u3068\u306b\u6700\u9069\u306a\u7d30\u80de\u6cbb\u7642\u304c\u53ef\u80fd\u306b<\/strong>\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>7-2-2. 3D\u30d0\u30a4\u30aa\u30d7\u30ea\u30f3\u30c6\u30a3\u30f3\u30b0\u306b\u3088\u308b\u81d3\u5668\u518d\u751f<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u3068\u30d0\u30a4\u30aa\u30d7\u30ea\u30f3\u30c6\u30a3\u30f3\u30b0\u6280\u8853\u306e\u9032\u5316\u306b\u3088\u308a\u3001<strong>\u5c06\u6765\u7684\u306b\u306f\u5b8c\u5168\u306a\u4eba\u5de5\u81d3\u5668\u306e\u4f5c\u88fd\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u5316\u81d3\u5668<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u60a3\u8005\u306e\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u62d2\u7d76\u53cd\u5fdc\u306e\u306a\u3044\u81d3\u5668\u3092\u4f5c\u88fd\u3002<\/li>\n\n\n\n<li><strong>\u814e\u81d3\u3001\u809d\u81d3\u3001\u81b5\u81d3\u306a\u3069\u306e\u81d3\u5668\u518d\u751f\u304c\u7814\u7a76\u6bb5\u968e\u306b\u3042\u308b<\/strong>\uff08<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/21922640\">\u53c2\u8003\uff1aAdvanced Healthcare Materials<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-9c414180-7fff-63ac-a5ae-65d8732ba87a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-3. \u907a\u4f1d\u5b50\u3068\u611f\u67d3\u75c7\u6cbb\u7642<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/28046375_m-1024x683.jpg\" alt=\"\u8d64\u3061\u3083\u3093\u306b\u4e88\u9632\u63a5\u7a2e\u3059\u308b\u533b\u5e2b\" class=\"wp-image-3400\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/28046375_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/28046375_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/28046375_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/28046375_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/28046375_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306f\u611f\u67d3\u75c7\u6cbb\u7642\u306e\u5206\u91ce\u3067\u3082\u5927\u304d\u306a\u9032\u5c55\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>7-3-1. CRISPR\u3092\u7528\u3044\u305f\u6297\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5<\/strong><\/h4>\n\n\n\n<p>CRISPR\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u6297\u30a6\u30a4\u30eb\u30b9\u6cbb\u7642\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u304a\u308a\u3001<strong>HIV\u3084\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3001COVID-19\u306a\u3069\u306e\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u6cbb\u7642\u306b\u5fdc\u7528<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HIV\u306e\u907a\u4f1d\u5b50\u9664\u53bb<\/strong>\n<ul class=\"wp-block-list\">\n<li>CRISPR\u3092\u7528\u3044\u3066\u3001<strong>HIV\u30a6\u30a4\u30eb\u30b9\u306e\u30b2\u30ce\u30e0\u3092\u5bbf\u4e3b\u7d30\u80de\u304b\u3089\u5b8c\u5168\u306b\u9664\u53bb\u3059\u308b\u7814\u7a76<\/strong>\u304c\u9032\u884c\u4e2d\uff08<a href=\"https:\/\/www.nature.com\/ncomms\/\">\u53c2\u8003\uff1aNature Communications<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u4e88\u6e2c\u3068\u907a\u4f1d\u5b50\u89e3\u6790<\/strong>\n<ul class=\"wp-block-list\">\n<li>AI\u3068\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u5909\u7570\u3092\u4e88\u6e2c\u3057\u3001<strong>\u4e8b\u524d\u306b\u30ef\u30af\u30c1\u30f3\u3092\u958b\u767a\u3059\u308b\u6280\u8853\u304c\u9032\u5316<\/strong>\u3002<\/li>\n\n\n\n<li>\u672a\u6765\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u5bfe\u7b56\u3068\u3057\u3066\u3001\u907a\u4f1d\u5b50\u30d9\u30fc\u30b9\u306e\u9632\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7-4. \u907a\u4f1d\u5b50\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9<\/strong><\/h3>\n\n\n\n<p>\u7cbe\u795e\u75be\u60a3\u3068\u907a\u4f1d\u5b50\u306e\u95a2\u4fc2\u3082\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u3001<strong>\u500b\u4eba\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306b\u57fa\u3065\u3044\u305f\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85<\/strong>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30bb\u30ed\u30c8\u30cb\u30f3\u8f38\u9001\u4f53\u907a\u4f1d\u5b50\uff08SLC6A4\uff09\u3068\u3046\u3064\u75c5<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u3063\u3066\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u518d\u5438\u53ce\u7387\u304c\u7570\u306a\u308a\u3001<strong>\u6297\u3046\u3064\u85ac\u306e\u52b9\u679c\u306b\u500b\u4eba\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u5224\u660e<\/strong>\uff08<a href=\"https:\/\/www.nature.com\/mp\/\">\u53c2\u8003\uff1aMolecular Psychiatry<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d5\u30a1\u30fc\u30de\u30b3\u30b2\u30ce\u30df\u30af\u30b9\u306b\u3088\u308b\u6297\u7cbe\u795e\u75c5\u85ac\u306e\u6700\u9069\u5316<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u3082\u3068\u306b\u3001<strong>\u7d71\u5408\u5931\u8abf\u75c7\u3084\u3046\u3064\u75c5\u306b\u5bfe\u3057\u3066\u6700\u9069\u306a\u85ac\u5264\u3092\u9078\u629e<\/strong>\u3059\u308b\u6280\u8853\u304c\u9032\u5316\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Cancer Immunology Research \u2013 \u30cd\u30aa\u30a2\u30f3\u30c1\u30b2\u30f3\u30ef\u30af\u30c1\u30f3<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/nm\/\">Nature Medicine \u2013 mRNA\u30ef\u30af\u30c1\u30f3\u306e\u304c\u3093\u6cbb\u7642\u5fdc\u7528<\/a><\/li>\n\n\n\n<li>Stem Cell Reports \u2013 iPS\u7d30\u80de\u3068\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/ncomms\/\">Nature Communications \u2013 CRISPR\u3068HIV\u6cbb\u7642<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/mp\/\">Molecular Psychiatry \u2013 \u907a\u4f1d\u5b50\u3068\u7cbe\u795e\u75be\u60a3<\/a><\/li>\n<\/ol>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u7814\u7a76\u304c\u3082\u305f\u3089\u3059\u672a\u6765\u306e\u533b\u7642\u9769\u547d<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306f\u3001\u533b\u7642\u306e\u3042\u3089\u3086\u308b\u5206\u91ce\u306b\u9769\u65b0\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u307e\u3059\u3002\u5f93\u6765\u306e\u6cbb\u7642\u3067\u306f\u5bfe\u51e6\u304c\u56f0\u96e3\u3060\u3063\u305f\u75be\u60a3\u306e\u6839\u672c\u7684\u306a\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u75c5\u6c17\u306e\u767a\u75c7\u3092\u672a\u7136\u306b\u9632\u3050\u4e88\u9632\u533b\u5b66\u306e\u7cbe\u5ea6\u3082\u5411\u4e0a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001<strong>\u907a\u4f1d\u5b50\u7814\u7a76\u304c\u3082\u305f\u3089\u3059\u672a\u6765\u306e\u533b\u7642\u9769\u547d\u3068\u3001\u305d\u308c\u304c\u3069\u306e\u3088\u3046\u306b\u79c1\u305f\u3061\u306e\u5065\u5eb7\u3092\u5909\u3048\u3066\u3044\u304f\u306e\u304b<\/strong>\u3092\u8003\u5bdf\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-1. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"667\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/25027650_m-1024x667.jpg\" alt=\"\u982d\u3092\u62b1\u3048\u308b\u7537\u6027\" class=\"wp-image-3407\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/25027650_m-1024x667.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/25027650_m-300x195.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/25027650_m-768x500.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/25027650_m-1536x1000.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/25027650_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>8-1-1. \u60a3\u8005\u3054\u3068\u306e\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u306e\u9078\u629e<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u500b\u3005\u306e\u60a3\u8005\u306b\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u3092\u63d0\u4f9b\u3059\u308b<strong>\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u533b\u7642<\/strong>\u306e\u5b9f\u73fe\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u304c\u3093\u6cbb\u7642\u306e\u500b\u5225\u5316<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u89e3\u6790\u306b\u3088\u308a\u3001<strong>\u7279\u5b9a\u306e\u5206\u5b50\u6a19\u7684\u85ac\uff08\u4f8b\uff1aHER2\u967d\u6027\u4e73\u304c\u3093\u306e\u30cf\u30fc\u30bb\u30d7\u30c1\u30f3\uff09\u304c\u9069\u7528\u3067\u304d\u308b\u304b\u3092\u5224\u65ad<\/strong>\u3067\u304d\u308b\u3002<\/li>\n\n\n\n<li>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u52b9\u679c\u3092\u4e88\u6e2c\u3059\u308b\u6280\u8853\u3082\u9032\u5316\uff08\u53c2\u8003\uff1aJournal of Clinical Oncology\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u7ba1\u7406<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u5909\u7570\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001<strong>\u8840\u5727\u3084\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u8981\u56e0\u3092\u7279\u5b9a<\/strong>\u3057\u3001\u6700\u9069\u306a\u6cbb\u7642\u85ac\u3092\u9078\u629e\u3067\u304d\u308b\u3002<\/li>\n\n\n\n<li>PCSK9\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u3092\u4e88\u6e2c\u3057\u3001\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u8a66\u307f\u3082\u9032\u3093\u3067\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>8-1-2. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u7cbe\u5bc6\u4e88\u9632\u533b\u7642<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u7528\u3044\u3066\u3001<strong>\u75c5\u6c17\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e8b\u524d\u306b\u8a55\u4fa1\u3057\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3084\u85ac\u7269\u7642\u6cd5\u306b\u3088\u308b\u4e88\u9632\u3092\u884c\u3046\u8a66\u307f<\/strong>\u304c\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u306e\u65e9\u671f\u4e88\u6e2c<\/strong>\n<ul class=\"wp-block-list\">\n<li>TCF7L2\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u6301\u3064\u4eba\u306f\u3001<strong>2\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u5224\u660e<\/strong>\u3002<\/li>\n\n\n\n<li>\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3068\u306b\u3001\u6700\u9069\u306a\u98df\u4e8b\u30fb\u904b\u52d5\u30d7\u30e9\u30f3\u3092\u63d0\u6848\u3059\u308b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\uff08\u53c2\u8003\uff1aDiabetes Care\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-2. \u907a\u4f1d\u5b50\u3068\u9577\u5bff\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>8-2-1. \u9577\u5bff\u907a\u4f1d\u5b50\u306e\u89e3\u6790\u3068\u5fdc\u7528<\/strong><\/h4>\n\n\n\n<p>100\u6b73\u4ee5\u4e0a\u306e\u9577\u5bff\u8005\u306e\u907a\u4f1d\u5b50\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u9577\u5bff\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0\u304c\u89e3\u660e\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059<\/strong>\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FOXO3\u907a\u4f1d\u5b50\u306e\u5f71\u97ff<\/strong>\n<ul class=\"wp-block-list\">\n<li>FOXO3\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u4eba\u306f\u3001<strong>\u5065\u5eb7\u5bff\u547d\u304c\u9577\u3044\u50be\u5411\u304c\u3042\u308b<\/strong>\u3002<\/li>\n\n\n\n<li>\u3053\u306e\u907a\u4f1d\u5b50\u306f<strong>\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3084\u6297\u9178\u5316\u4f5c\u7528\u3092\u5f37\u5316\u3057\u3001\u8001\u5316\u3092\u9045\u3089\u305b\u308b<\/strong>\u50cd\u304d\u3092\u6301\u3064\uff08<a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/14749726\">\u53c2\u8003\uff1aAging Cell<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>SIRT1\u907a\u4f1d\u5b50\u3068\u30ab\u30ed\u30ea\u30fc\u5236\u9650<\/strong>\n<ul class=\"wp-block-list\">\n<li>SIRT1\u306f\u9577\u5bff\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001<strong>\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3057\u3001\u7d30\u80de\u306e\u4fee\u5fa9\u6a5f\u80fd\u3092\u5411\u4e0a\u3055\u305b\u308b<\/strong>\u3002<\/li>\n\n\n\n<li>\u3053\u308c\u3092\u6a21\u5023\u3059\u308b\u7269\u8cea\uff08\u4f8b\uff1a\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff09\u304c\u8001\u5316\u9632\u6b62\u85ac\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>8-2-2. \u907a\u4f1d\u5b50\u7de8\u96c6\u306b\u3088\u308b\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0<\/strong><\/h4>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u3092\u6d3b\u7528\u3057\u3066\u3001<strong>\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u53ef\u80fd\u304b\u3069\u3046\u304b<\/strong>\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30c6\u30ed\u30e1\u30a2\u306e\u5ef6\u9577<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u306f\u8001\u5316\u306e\u539f\u56e0\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>TERT\u907a\u4f1d\u5b50\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u30c6\u30ed\u30e1\u30a2\u3092\u5ef6\u9577\u3057\u3001\u7d30\u80de\u306e\u5bff\u547d\u3092\u5ef6\u3070\u3059\u8a66\u307f<\/strong>\u304c\u884c\u308f\u308c\u3066\u3044\u308b\uff08<a href=\"https:\/\/www.nature.com\/nataging\/\">\u53c2\u8003\uff1aNature Aging<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><span id=\"docs-internal-guid-9c414180-7fff-63ac-a5ae-65d8732ba87a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-3. \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u6d3b\u7528\u3068\u502b\u7406\u7684\u8ab2\u984c<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/31483995_m-1024x585.jpg\" alt=\"\u30b9\u30de\u30db\u306e\u753b\u9762\u306b\u6d6e\u304b\u3076\uff1f\u30de\u30fc\u30af\" class=\"wp-image-3414\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31483995_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31483995_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31483995_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31483995_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31483995_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u533b\u7642\u304c\u767a\u5c55\u3059\u308b\u4e00\u65b9\u3067\u3001<strong>\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u306e\u4fdd\u8b77\u3084\u502b\u7406\u7684\u306a\u8ab2\u984c\u3082\u91cd\u8981\u306a\u30c6\u30fc\u30de\u3068\u306a\u3063\u3066\u3044\u307e\u3059<\/strong>\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>8-3-1. \u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u304c\u4e0d\u6b63\u5229\u7528\u3055\u308c\u308b\u30ea\u30b9\u30af<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306f\u3001\u4fdd\u967a\u4f1a\u793e\u3084\u96c7\u7528\u4e3b\u306b\u3088\u3063\u3066\u4e0d\u9069\u5207\u306b\u5229\u7528\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u3053\u308c\u3092\u9632\u3050\u305f\u3081\u306b\u3001<strong>\u300c\u907a\u4f1d\u60c5\u5831\u975e\u5dee\u5225\u6cd5\uff08GINA\uff09\u300d\u306e\u3088\u3046\u306a\u6cd5\u5f8b\u304c\u6574\u5099\u3055\u308c\u3064\u3064\u3042\u308b<\/strong>\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30c7\u30fc\u30bf\u7ba1\u7406\u306e\u900f\u660e\u6027<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f01\u696d\u3084\u533b\u7642\u6a5f\u95a2\u304c\u3069\u306e\u3088\u3046\u306b\u907a\u4f1d\u60c5\u5831\u3092\u6271\u3046\u304b\u306b\u3064\u3044\u3066\u3001\u660e\u78ba\u306a\u30eb\u30fc\u30eb\u306e\u78ba\u7acb\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>8-3-2. \u907a\u4f1d\u5b50\u7de8\u96c6\u306e\u502b\u7406\u7684\u8ab2\u984c<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30c7\u30b6\u30a4\u30ca\u30fc\u30d9\u30d3\u30fc\u306e\u554f\u984c<\/strong>\n<ul class=\"wp-block-list\">\n<li>CRISPR\u6280\u8853\u3092\u7528\u3044\u305f\u80da\u306e\u907a\u4f1d\u5b50\u7de8\u96c6\u306f\u3001\u5c06\u6765\u7684\u306b**\u300c\u512a\u308c\u305f\u907a\u4f1d\u5b50\u300d\u3092\u6301\u3064\u5b50\u4f9b\u3092\u610f\u56f3\u7684\u306b\u4f5c\u308a\u51fa\u3059\u5371\u967a\u6027\u304c\u3042\u308b**\u3002<\/li>\n\n\n\n<li>\u3053\u308c\u304c\u793e\u4f1a\u7684\u306a\u683c\u5dee\u3084\u502b\u7406\u7684\u306a\u554f\u984c\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u56fd\u969b\u7684\u306a\u8b70\u8ad6\u304c\u7d9a\u3044\u3066\u3044\u308b\uff08<a href=\"https:\/\/www.nature.com\/ethics\/\">\u53c2\u8003\uff1aNature Ethics<\/a>\uff09\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8ffd\u52a0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ea\u30f3\u30af<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Journal of Clinical Oncology \u2013 \u304c\u3093\u306e\u500b\u5225\u5316\u6cbb\u7642<\/li>\n\n\n\n<li>Diabetes Care \u2013 \u907a\u4f1d\u5b50\u3068\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af<\/li>\n\n\n\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/14749726\">Aging Cell \u2013 FOXO3\u907a\u4f1d\u5b50\u3068\u9577\u5bff<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/nataging\/\">Nature Aging \u2013 \u30c6\u30ed\u30e1\u30a2\u3068\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/ethics\/\">Nature Ethics \u2013 \u907a\u4f1d\u5b50\u502b\u7406\u306e\u8b70\u8ad6<\/a><\/li>\n<\/ol>\n\n\n\n<p><span id=\"docs-internal-guid-9c414180-7fff-63ac-a5ae-65d8732ba87a\"><span style=\"font-size: 11pt; font-family: Arial, sans-serif; background-color: transparent; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; font-variant-emoji: normal; vertical-align: baseline;\"><div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div><\/span><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001<strong>\u75c5\u6c17\u306e\u4e88\u9632\u3001\u500b\u5225\u5316\u6cbb\u7642\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\u3001\u518d\u751f\u533b\u7642\u306a\u3069\u3001\u533b\u7642\u306e\u3042\u3089\u3086\u308b\u5206\u91ce\u3067\u9769\u65b0\u304c\u9032\u3093\u3067\u3044\u307e\u3059<\/strong>\u3002\u304c\u3093\u6cbb\u7642\u306e\u500b\u5225\u5316\u3084\u795e\u7d4c\u75be\u60a3\u3078\u306e\u5fdc\u7528\u3001\u9577\u5bff\u907a\u4f1d\u5b50\u306e\u7814\u7a76\u306a\u3069\u3001\u79d1\u5b66\u306e\u9032\u6b69\u306f\u5065\u5eb7\u5bff\u547d\u306e\u5ef6\u9577\u306b\u3082\u8ca2\u732e\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u4fdd\u8b77\u3084\u502b\u7406\u7684\u8ab2\u984c\u3082\u91cd\u8981\u306a\u554f\u984c\u3068\u3057\u3066\u8b70\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002<strong>\u4eca\u5f8c\u3001\u6280\u8853\u306e\u767a\u5c55\u3068\u502b\u7406\u7684\u306a\u67a0\u7d44\u307f\u306e\u6574\u5099\u3092\u4e21\u7acb\u3055\u305b\u306a\u304c\u3089\u3001\u907a\u4f1d\u5b50\u533b\u7642\u306f\u3088\u308a\u5b89\u5168\u3067\u52b9\u679c\u7684\u306a\u65b9\u5411\u3078\u3068\u9032\u5316\u3057\u3066\u3044\u304f\u3067\u3057\u3087\u3046<\/strong>\u3002<\/p>\n\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306f\u3001\u533b\u7642\u306e\u3042\u308a\u65b9\u3092\u5927\u304d\u304f\u5909\u3048\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u75c5\u6c17\u306e\u539f\u56e0\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u7279\u5b9a\u3057\u3001\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u306b\u57fa\u3065\u3044\u305f\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u304b\u3064\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u533b\u7642\u304c\u5b9f\u73fe\u3057\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306e\u9032\u5316\u3001 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