{"id":15442,"date":"2024-11-26T03:39:20","date_gmt":"2024-11-26T03:39:20","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/alcohol-metabolism-genetics-hiroclinic\/"},"modified":"2026-07-18T00:14:13","modified_gmt":"2026-07-18T00:14:13","slug":"alcohol-metabolism-genetics-hiroclinic-zh","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/alcohol-metabolism-genetics-hiroclinic-zh\/","title":{"rendered":"\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\u63ed\u793a\u9152\u7cbe\u4ee3\u8c22\u7684\u5dee\u5f02"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\"><strong><strong>\u57fa\u56e0\u4e0e\u9152\u7cbe\u4ee3\u8c22\u7684\u5173\u7cfb<\/strong><\/strong><\/h3>\n\n\n\n<p>\u996e\u9152\u540e\uff0c\u9152\u7cbe\u5728\u4f53\u5185\u5206\u89e3\u7684\u901f\u5ea6\u4ee5\u53ca\u5bf9\u8eab\u4f53\u7684\u5f71\u54cd\u56e0\u4eba\u800c\u5f02\u3002\u9020\u6210\u8fd9\u79cd\u5dee\u5f02\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u662f\u57fa\u56e0\u3002\u6700\u8fd1\u7684\u57fa\u56e0\u7814\u7a76\u8868\u660e\uff0c\u4ee3\u8c22\u9152\u7cbe\u7684\u80fd\u529b\u662f\u7531\u57fa\u56e0\u51b3\u5b9a\u7684\u3002\u7279\u522b\u662f\u5c06\u9152\u7cbe\u5206\u89e3\u4e3a\u4e59\u919b\u7684<strong>ADH1B<\/strong>\u57fa\u56e0\u548c\u5c06\u4e59\u919b\u8f6c\u5316\u4e3a\u4e59\u9178\u7684<strong>ALDH2<\/strong>\u57fa\u56e0\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002<a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/p>\n\n\n\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>\u53c2\u4e0e\u9152\u7cbe\u4ee3\u8c22\u7684\u5173\u952e\u57fa\u56e0<\/strong><\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31721330_m-1024x683.jpg\" alt=\"\" class=\"wp-image-7059\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31721330_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31721330_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31721330_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31721330_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31721330_m.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong><strong>ADH1B\uff08\u9152\u7cbe\u8131\u6c22\u9176 1B\uff09<\/strong><br><\/strong>ADH1B \u57fa\u56e0\u51b3\u5b9a\u5c06\u9152\u7cbe\u8f6c\u5316\u4e3a\u4e59\u919b\u7684\u9176\u7684\u6d3b\u6027\u3002\u7531\u4e8e\u8fd9\u4e9b\u57fa\u56e0\u5dee\u5f02\uff0c\u6709\u4e9b\u4eba\u5206\u89e3\u9152\u7cbe\u7684\u901f\u5ea6\u6bd4\u5176\u4ed6\u4eba\u66f4\u5feb\u3002\n<ul class=\"wp-block-list\">\n<li><strong>\u5feb\u901f\u578b\uff08ADH1B*2\uff09<\/strong>\uff1a\u6b64\u7c7b\u578b\u4e3b\u8981\u89c1\u4e8e\u4e1c\u4e9a\u4eba\uff0c\u9152\u7cbe\u5f88\u5feb\u8f6c\u5316\u4e3a\u4e59\u919b\uff0c\u5bfc\u81f4\u8138\u8272\u5bb9\u6613\u53d1\u7ea2\u3002<\/li>\n\n\n\n<li><strong>\u6162\u578b\uff08ADH1B*1\uff09<\/strong>\uff1a\u5728\u897f\u65b9\u4eba\u4e2d\u5f88\u5e38\u89c1\uff0c\u8fd9\u79cd\u7c7b\u578b\u7684\u4eba\u5206\u89e3\u9152\u7cbe\u7684\u901f\u5ea6\u5f88\u6162\uff0c\u6240\u4ee5\u4ed6\u4eec\u4e0d\u5bb9\u6613\u559d\u9189\uff0c\u4f46\u5f80\u5f80\u4f1a\u559d\u5f97\u66f4\u591a\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><strong>ALDH2\uff08\u4e59\u919b\u8131\u6c22\u9176 2<\/strong>\uff09<br><\/strong>ALDH2 \u57fa\u56e0\u4ea7\u751f\u4e00\u79cd\u9176\uff0c\u5c06\u4e59\u919b\u8f6c\u5316\u4e3a\u65e0\u5bb3\u7684\u4e59\u9178\u3002\n<ul class=\"wp-block-list\">\n<li><strong>\u6d3b\u6027\u578b\uff08ALDH2*1\/*1\uff09<\/strong>\uff1a\u80fd\u6709\u6548\u5206\u89e3\u4e59\u919b\uff0c\u56e0\u6b64\u53d7\u9152\u7cbe\u7684\u5f71\u54cd\u8f83\u5c0f\u3002<\/li>\n\n\n\n<li><strong>\u4f4e\u6d3b\u6027\u578b\uff08ALDH2*1\/*2\uff09<\/strong>\uff1a\u5206\u89e3\u4e59\u919b\u7684\u80fd\u529b\u4f4e\uff0c\u559d\u9152\u540e\u8138\u8272\u7acb\u5373\u53d8\u7ea2\u3002<\/li>\n\n\n\n<li><strong>\u975e\u6d3b\u6027\u578b\uff08ALDH2*2\/*2\uff09<\/strong>\uff1a\u60a3\u6709\u8fd9\u79cd\u7c7b\u578b\u7684\u4eba\u65e0\u6cd5\u5206\u89e3\u4e59\u919b\uff0c\u56e0\u6b64\u5f88\u96be\u996e\u9152\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>\u65e5\u672c\u4eba\u7684\u5e38\u89c1\u57fa\u56e0\u578b\u548c\u9152\u7cbe\u8010\u53d7\u6027<\/strong><\/strong><\/h3>\n\n\n\n<p>\u636e\u62a5\u9053\uff0c\u65e5\u672c\u7ea6\u670940%\u7684\u4ebaALDH2\u6d3b\u6027\u8f83\u4f4e\uff0c\u7ea6\u67095%\u7684\u4ebaALDH2\u4e0d\u6d3b\u8dc3\u3002\u56e0\u6b64\uff0c\u8bb8\u591a\u65e5\u672c\u4eba\u5728\u996e\u9152\u540e\u4f1a\u51fa\u73b0\u8138\u8272\u53d8\u7ea2\u7684\u201c\u6f6e\u7ea2\u53cd\u5e94\u201d\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u8bb8\u591a\u4eba\u60a3\u6709\u5feb\u901f\u578b ADH1B\uff0c\u8fd9\u610f\u5473\u7740\u9152\u7cbe\u4f1a\u5feb\u901f\u8f6c\u5316\u4e3a\u4e59\u919b\uff0c\u4ed6\u4eec\u66f4\u5bb9\u6613\u9189\u9152\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>\u57fa\u56e0\u68c0\u6d4b\u80fd\u544a\u8bc9\u4f60\u4ec0\u4e48<\/strong><\/strong><\/h3>\n\n\n\n<p>\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\uff0c\u60a8\u53ef\u4ee5\u4e86\u89e3\u60a8\u7684 ADH1B \u548c ALDH2 \u7c7b\u578b\u3002\u8fd9\u5c06\u5e2e\u52a9\u60a8\u4e86\u89e3\u81ea\u5df1\u7684\u9152\u7cbe\u8010\u53d7\u5ea6\u5e76\u907f\u514d\u8fc7\u91cf\u996e\u9152\u3002\u5c24\u5176\u662f ALDH2 \u529f\u80fd\u4e0d\u6d3b\u8dc3\u7684\u4eba\u66f4\u5e94\u5c0f\u5fc3\uff0c\u56e0\u4e3a\u4ed6\u4eec\u56e0\u996e\u9152\u800c\u9762\u4e34\u66f4\u9ad8\u7684\u5065\u5eb7\u98ce\u9669\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. <strong>\u57fa\u56e0\u548c\u9152\u7cbe\u4ee3\u8c22\u7684\u57fa\u7840\u77e5\u8bc6<\/strong><\/strong><\/h2>\n\n\n\n<p>\u9152\u7cbe\u5bf9\u6bcf\u4e2a\u4eba\u7684\u5f71\u54cd\u4e0d\u540c\u3002\u5373\u4f7f\u559d\u540c\u6837\u91cf\u7684\u9152\uff0c\u6709\u4e9b\u4eba\u53ef\u80fd\u4f1a\u5f88\u5feb\u9189\uff0c\u800c\u6709\u4e9b\u4eba\u53ef\u80fd\u6839\u672c\u4e0d\u4f1a\u9189\u3002\u8fd9\u79cd\u5dee\u5f02\u80cc\u540e\u7684\u4e3b\u8981\u56e0\u7d20\u4e4b\u4e00\u662f\u9057\u4f20\u56e0\u7d20\u3002\u5177\u4f53\u6765\u8bf4\uff0c<strong>ADH1B<\/strong>\uff08\u9152\u7cbe\u8131\u6c22\u91761B\uff09\u548c<strong>ALDH2<\/strong>\uff08\u4e59\u919b\u8131\u6c22\u91762\uff09\u4e24\u79cd\u57fa\u56e0\u4e0e\u9152\u7cbe\u4ee3\u8c22\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n\n\n\n<p>\u4e86\u89e3\u60a8\u7684\u57fa\u56e0\u578b\u53ef\u4ee5\u5e2e\u52a9\u60a8\u4e86\u89e3\u5982\u4f55\u5206\u89e3\u9152\u7cbe\u5e76\u5e2e\u52a9\u60a8\u7ba1\u7406\u996e\u9152\u98ce\u9669\u3002\u8fd1\u5e74\u6765\uff0c\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u7684\u8fdb\u6b65\u4f7f\u5f97\u901a\u8fc7\u7b80\u5355\u7684\u553e\u6db2\u6216\u8840\u6db2\u6837\u672c\u5206\u6790\u9152\u7cbe\u4ee3\u8c22\u80fd\u529b\u6210\u4e3a\u53ef\u80fd\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. <strong>\u9152\u7cbe\u4ee3\u8c22<\/strong><\/strong><\/h2>\n\n\n\n<p>\u9152\u7cbe\u5728\u4f53\u5185\u7684\u4ee3\u8c22\u65b9\u5f0f\u5982\u4e0b:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u4e59\u9187\uff08\u9152\u7cbe\uff09<\/strong>\u5728ADH1B\u9176\u7684\u4f5c\u7528\u4e0b\u8f6c\u5316\u4e3a\u4e59\u919b\u3002<\/li>\n\n\n\n<li><strong>\u4e59\u919b<\/strong>\u88ab<strong>ALDH2 \u9176<\/strong>\u5206\u89e3\u6210\u65e0\u5bb3\u7684<strong>\u4e59\u9178\u3002<\/strong><\/li>\n\n\n\n<li><strong>\u4e59\u9178<\/strong>\u6700\u7ec8\u5206\u89e3\u4e3a\u6c34\u548c\u4e8c\u6c27\u5316\u78b3\u5e76\u6392\u51fa\u4f53\u5916\u3002<\/li>\n<\/ol>\n\n\n\n<p>\u5f53\u8fd9\u4e2a\u8fc7\u7a0b\u51fa\u73b0\u95ee\u9898\u65f6\uff0c\u4e59\u919b\u5c31\u4f1a\u5728\u4f53\u5185\u79ef\u805a\uff0c\u5bfc\u81f4\u9762\u90e8\u53d1\u7ea2\u3001\u6076\u5fc3\u548c\u5fc3\u60b8\u3002\u5c24\u5176\u662f ALDH2 \u57fa\u56e0\u6d3b\u6027\u4f4e\u7684\u4eba\uff0c\u7531\u4e8e\u4e59\u919b\u5206\u89e3\u901f\u5ea6\u8f83\u6162\uff0c\u66f4\u5bb9\u6613\u53d7\u5230\u9152\u7cbe\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>3. ADH1B\u57fa\u56e0\u591a\u6001\u6027\u53ca\u5176\u6548\u5e94<\/strong><\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-1024x576.jpg\" alt=\"\u907a\u4f1d\u5b50\u3000CG\" class=\"wp-image-5043\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-1024x576.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-300x169.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-768x432.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m-1536x864.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/26403934_m.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>**ADH1B \u57fa\u56e0\u7684\u7c7b\u578b\u51b3\u5b9a\u4e86\u9152\u7cbe\u8f6c\u5316\u4e3a\u4e59\u919b\u7684\u901f\u5ea6\u3002 **\u4e3b\u8981\u6709\u4e09\u79cd\u7c7b\u578b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ADH1B*1\/*1\uff08\u4f4e\u6d3b\u6027\u578b\uff09<\/strong>\uff1a\u9152\u7cbe\u5206\u89e3\u901f\u5ea6\u6162\uff0c\u4e0d\u6613\u9189\u9152\uff0c\u4f46\u6709\u66f4\u5bb9\u6613\u4ea7\u751f\u9152\u7cbe\u4f9d\u8d56\u7684\u503e\u5411\u3002<\/li>\n\n\n\n<li><strong>ADH1B*1\/*2\uff08\u4e2d\u95f4\u578b\uff09<\/strong>\uff1a\u9152\u7cbe\u5206\u89e3\u5f97\u6bd4\u8f83\u5feb\u3002<\/li>\n\n\n\n<li><strong>ADH1B*2\/*2\uff08\u9ad8\u6d3b\u6027\u578b\uff09<\/strong>\uff1a\u5feb\u901f\u5c06\u9152\u7cbe\u8f6c\u5316\u4e3a\u4e59\u919b\uff0c\u4f7f\u4eba\u66f4\u5bb9\u6613\u9189\u9152\u5e76\u51fa\u73b0\u6f6e\u7ea2\u53cd\u5e94\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8bb8\u591a\u65e5\u672c\u4eba<strong>\u60a3\u6709 1B*2 \u578b\u6297\u5229\u5c3f\u6fc0\u7d20 (ADH)\uff0c\u8fd9\u79cd\u6fc0\u7d20\u4f1a\u8fc5\u901f\u5c06\u9152\u7cbe\u8f6c\u5316\u4e3a\u4e59\u919b\uff0c<\/strong>\u4f7f\u4ed6\u4eec\u66f4\u5bb9\u6613\u9189\u9152\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>4. ALDH2 \u57fa\u56e0\u591a\u6001\u6027\u53ca\u5176\u5f71\u54cd<\/strong><\/strong><\/h2>\n\n\n\n<p>ALDH2\u57fa\u56e0\u7684\u7c7b\u578b\u51b3\u5b9a\u4e86\u4eba\u4f53\u5206\u89e3\u4e59\u919b\u7684\u80fd\u529b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ALDH2*1\/*1\uff08\u6d3b\u6027\u578b\uff09<\/strong>\uff1a\u80fd\u5feb\u901f\u5206\u89e3\u4e59\u919b\uff0c\u56e0\u6b64\u53d7\u9152\u7cbe\u5f71\u54cd\u8f83\u5c0f\u3002<\/li>\n\n\n\n<li><strong>ALDH2*1\/*2\uff08\u4f4e\u6d3b\u6027\u578b\uff09<\/strong>\uff1a\u4e59\u919b\u5206\u89e3\u7f13\u6162\uff0c\u5bfc\u81f4\u996e\u9152\u540e\u8138\u8272\u53d1\u7ea2\uff08\u6f6e\u7ea2\u53cd\u5e94\uff09\u3002<\/li>\n\n\n\n<li><strong>ALDH2*2\/*2\uff08\u975e\u6d3b\u6027\u578b\uff09<\/strong>\uff1a\u4eba\u4f53\u51e0\u4e4e\u65e0\u6cd5\u5206\u89e3\u4e59\u919b\uff0c\u56e0\u6b64\u996e\u9152\u6781\u5176\u56f0\u96be\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7279\u522b\u662f<strong>\u5177\u6709 ALDH2*2 \u578b\u7684\u4eba\uff0c\u5373\u4f7f\u996e\u7528\u5c11\u91cf\u9152\u7cbe\u4e5f\u5e38\u5e38\u4f1a\u51fa\u73b0\u5fc3\u7387\u52a0\u5feb\u548c\u6076\u5fc3\u7684\u75c7\u72b6<\/strong>\u3002\u8fd9\u5c31\u662f\u4e59\u919b\u79ef\u7d2f\u7684\u6548\u5e94\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>5. \u65e5\u672c\u4eba\u7684\u57fa\u56e0\u578b\u5206\u5e03\u548c\u9152\u7cbe\u8010\u53d7\u6027<\/strong><\/strong><\/h2>\n\n\n\n<p>\u636e\u7814\u7a76\uff0c\u65e5\u672c\u4eba\u7684\u57fa\u56e0\u578b\u6bd4\u4f8b\u5982\u4e0b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**ALDH2 \u6d3b\u6027\u7c7b\u578b\uff08ALDH2\u00a0<em>1\/1\uff09\uff1a\u7ea6 55%<\/em><\/li>\n\n\n\n<li>**ALDH2 \u4f4e\u6d3b\u6027\u578b\uff08ALDH2\u00a0<em>1\/2\uff09\uff1a\u7ea6 40%<\/em><\/li>\n\n\n\n<li>**ALDH2 \u975e\u6d3b\u6027\u578b\uff08ALDH2\u00a0<em>2\/2\uff09\uff1a\u7ea6 5%<\/em><\/li>\n<\/ul>\n\n\n\n<p>\u6362\u53e5\u8bdd\u8bf4\uff0c\u867d\u7136\u5927\u7ea6\u4e00\u534a\u7684\u65e5\u672c\u4eba\u5177\u6709\u201c\u9ad8\u5ea6\u9152\u7cbe\u8010\u53d7\u6027\u201d\u7684\u57fa\u56e0\u6784\u6210\uff0c\u4f46\u8d85\u8fc7 40% \u7684\u4eba\u53ef\u80fd\u5177\u6709\u201c\u4f4e\u9152\u7cbe\u8010\u53d7\u6027\u201d\u7684\u4f53\u8d28\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>6. \u57fa\u56e0\u68c0\u6d4b\u7684\u597d\u5904<\/strong><\/strong><\/h2>\n\n\n\n<p>\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u7684\u597d\u5904\u5305\u62ec\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>\u2460 \u4e86\u89e3\u81ea\u5df1\u7684\u9152\u7cbe\u8010\u53d7\u91cf<\/strong><\/strong><\/h3>\n\n\n\n<p>\u60a8\u53ef\u4ee5\u907f\u514d\u8fc7\u91cf\u996e\u9152\u5e76\u627e\u5230\u9002\u5408\u60a8\u7684\u9002\u91cf\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>\u2461 \u5065\u5eb7\u98ce\u9669\u7ba1\u7406<\/strong><\/strong><\/h3>\n\n\n\n<p>ALDH2 \u6d3b\u6027\u8f83\u4f4e\u6216\u4e0d\u6d3b\u8dc3\u7684\u4eba\u60a3\u98df\u9053\u764c\u548c\u809d\u75c5\u7684\u98ce\u9669\u66f4\u9ad8\uff0c\u56e0\u6b64\u4ed6\u4eec\u53ef\u80fd\u9700\u8981\u91cd\u65b0\u8003\u8651\u81ea\u5df1\u7684\u996e\u9152\u4e60\u60ef\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2462 <strong>\u9884\u9632\u9157\u9152<\/strong><\/strong><\/h3>\n\n\n\n<p>ADH1B \u6d3b\u6027\u4f4e\u7684\u4eba\u5bb9\u6613\u9157\u9152\uff0c\u56e0\u6b64\u9700\u8981\u6ce8\u610f\u81ea\u5df1\u7684\u996e\u9152\u4e60\u60ef\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>7. \u57fa\u56e0\u578b\u4e0e\u9152\u7cbe\u76f8\u5173\u75be\u75c5\u7684\u98ce\u9669<\/strong><\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31431602_m-1024x683.jpg\" alt=\"\" class=\"wp-image-7086\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31431602_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31431602_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31431602_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31431602_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31431602_m.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u6211\u4eec\u4ee3\u8c22\u9152\u7cbe\u7684\u80fd\u529b\u662f\u7531\u57fa\u56e0\u51b3\u5b9a\u7684\uff0c\u8fd9\u4e0d\u4ec5\u4e0e\u6211\u4eec\u662f\u5426\u80fd\u8010\u53d7\u9152\u7cbe\u6709\u5173\uff0c\u8fd8\u4e0e\u5404\u79cd\u5065\u5eb7\u98ce\u9669\u6709\u5173\u3002\u7279\u522b\u662f\uff0c\u5df2\u77e5<strong>ALDH2 \u6d3b\u6027\u8f83\u4f4e\u6216\u4e0d\u6d3b\u8dc3\u7684\u4eba\u60a3\u9152\u7cbe\u76f8\u5173\u75be\u75c5\u7684\u98ce\u9669\u66f4\u9ad8\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>7-1\u3002\u4e0e\u98df\u9053\u764c\u7684\u5173\u7cfb<\/strong><\/strong><\/h3>\n\n\n\n<p>ALDH2 \u57fa\u56e0\u8f83\u4f4e\u6216\u4e0d\u6d3b\u8dc3\u7684\u4eba\u5206\u89e3\u4e59\u919b\u7684\u80fd\u529b\u964d\u4f4e\uff0c\u56e0\u6b64\u996e\u9152\u540e\u4e59\u919b\u4f1a\u5728\u4f53\u5185\u505c\u7559\u5f88\u957f\u65f6\u95f4\u3002<strong>\u4e59\u919b\u662f\u4e00\u79cd\u81f4\u764c\u7269\uff0c<\/strong>\u5927\u91cf\u7814\u7a76\u8868\u660e\uff0c\u5b83\u4f1a\u589e\u52a0\u60a3\u764c\u75c7\u7684\u98ce\u9669\uff0c\u5c24\u5176\u662f\u98df\u9053\u764c\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u79d1\u5b66\u8bc1\u636e<\/strong><\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6839\u636e<strong>\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76<\/strong>\uff0cALDH2\u6d3b\u6027\u4f4e\u7684\u4eba\u60a3<strong>\u98df\u9053\u764c\u7684\u98ce\u9669\u6bd4\u6b63\u5e38\u4eba\u9ad8\u51fa\u4e03\u500d\u4ee5\u4e0a\uff08<\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12345678\/\">\u53c2\u8003\u7814\u7a76<\/a>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u65e5\u672c\u7684\u6d41\u884c\u75c5\u5b66\u7814\u7a76<\/strong>\u8868\u660e\uff0c\u5177\u6709\u975e\u6d3b\u6027ALDH2\u578b\u4e14\u6709\u996e\u9152\u4e60\u60ef\u7684\u4eba\u7fa4\u98df\u9053\u764c\u53d1\u75c5\u7387\u7279\u522b\u9ad8\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u56e0\u6b64\uff0c\u4e86\u89e3 ALDH2 \u57fa\u56e0\u7684\u7c7b\u578b\u5bf9\u4e8e\u9884\u6d4b\u672a\u6765\u7684\u5065\u5eb7\u98ce\u9669\u548c\u5ba1\u67e5\u996e\u9152\u4e60\u60ef\u975e\u5e38\u91cd\u8981\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>7-2\u3002\u4e0e\u809d\u75c5\uff08\u809d\u786c\u5316\u548c\u809d\u764c\uff09\u7684\u5173\u8054<\/strong><\/strong><\/h3>\n\n\n\n<p>\u8fc7\u91cf\u996e\u9152\u4f1a\u7ed9\u809d\u810f\u5e26\u6765\u538b\u529b\uff0c\u5e76\u53ef\u80fd\u5bfc\u81f4\u809d\u786c\u5316\u548c\u809d\u764c\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u9152\u7cbe\u5206\u89e3\u7684\u901f\u5ea6\u548c\u9020\u6210\u7684\u4ee3\u8c22\u8d1f\u62c5\u56e0ADH1B\u548cALDH2\u57fa\u56e0\u578b\u800c\u5f02\uff0c<strong>\u5bf9\u809d\u810f\u7684\u5f71\u54cd\u4e5f\u4e0d\u540c\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u57fa\u56e0\u578b\u7279\u5f02\u6027\u98ce\u9669<\/strong><\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ALDH2 \u529f\u80fd\u88ab\u6fc0\u6d3b\uff08ALDH2*1\/*1\uff09\u7684\u4eba\u5f80\u5f80\u4f1a\u996e\u7528\u66f4\u591a\u7684\u9152\u7cbe\uff0c\u800c\u957f\u671f\u996e\u9152\u4f1a\u589e\u52a0\u60a3\u809d\u75c5\u7684\u98ce\u9669\u3002<\/li>\n\n\n\n<li>\u5bf9\u4e8e ALDH2 \u6d3b\u6027\u8f83\u4f4e\uff08ALDH2*1\/*2\uff09\u7684\u4eba\u6765\u8bf4\uff0c\u5373\u4f7f\u5c11\u91cf\u7684\u9152\u7cbe\u4e5f\u4f1a\u5bfc\u81f4\u4e59\u919b\u7684\u79ef\u7d2f\uff0c\u4ece\u800c\u7ed9\u809d\u810f\u5e26\u6765\u538b\u529b\u3002<\/li>\n\n\n\n<li>ADH1B\u6d3b\u6027\u4f4e\u7684\u4eba\uff08ADH1B*1\/*1\uff09\u4ee3\u8c22\u9152\u7cbe\u8f83\u6162\uff0c\u957f\u671f\u9ad8\u6d53\u5ea6\u7684\u4e59\u9187\u4f1a\u7ed9\u809d\u810f\u5e26\u6765\u538b\u529b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u79d1\u5b66\u8bc1\u636e<\/strong><\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u62a5\u544a<\/strong>\uff0c\u4e1c\u4e9a\u4eba\u7684\u9152\u7cbe\u6027\u809d\u75c5\u4e0e\u9057\u4f20\u56e0\u7d20\u5bc6\u5207\u76f8\u5173\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>7-3\u3002\u4e0e\u9157\u9152\u6709\u5173<\/strong><\/strong><\/h3>\n\n\n\n<p>\u4f17\u6240\u5468\u77e5\uff0c\u9157\u9152\u662f\u7531\u9057\u4f20\u548c\u73af\u5883\u56e0\u7d20\u9020\u6210\u7684\u3002\u636e\u62a5\u9053\uff0c\u643a\u5e26ADH1B\u57fa\u56e0\u4f4e\u6d3b\u6027\u578b\uff08ADH1B*1\/*1\uff09\u7684\u4eba\uff0c<strong>\u7531\u4e8e\u5206\u89e3\u9152\u7cbe\u7684\u901f\u5ea6\u8f83\u6162\uff0c\u996e\u9152\u65f6\u66f4\u5bb9\u6613\u611f\u5230\u6109\u60a6\uff0c\u8fd9\u589e\u52a0\u4e86\u4ed6\u4eec\u60a3\u4e0a\u9152\u7cbe\u4e2d\u6bd2\u7684\u98ce\u9669\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u79d1\u5b66\u8bc1\u636e<\/strong><\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7f8e\u56fd\u4e00\u9879\u7814\u7a76<\/strong>\u8868\u660e\uff0cADH1B\u6d3b\u6027\u4f4e\u7684\u4eba\u60a3\u9152\u7cbe\u4f9d\u8d56\u7684\u53ef\u80fd\u6027\u662f\u5176\u4ed6\u4eba\u7684\u4e24\u500d\u591a\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\u4e86\u89e3\u60a8\u662f\u5426\u6709\u9157\u9152\u503e\u5411\uff0c\u60a8\u5c31\u53ef\u4ee5\u91c7\u53d6\u9002\u5f53\u7684\u63aa\u65bd\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>8. \u57fa\u56e0\u68c0\u6d4b\u7684\u5177\u4f53\u6d41\u7a0b\u548c\u65b9\u6cd5<\/strong><\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-1024x585.jpg\" alt=\"\u907a\u4f1d\u5b50\u7814\u7a76\" class=\"wp-image-1167\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31198916_m.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u5728\u4e13\u95e8\u7684\u68c0\u6d4b\u5b9e\u9a8c\u5ba4\u53ef\u4ee5\u8f7b\u677e\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u3002\u5927\u81f4\u6d41\u7a0b\u5982\u4e0b\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-1. <strong>\u57fa\u56e0\u68c0\u6d4b\u6d41\u7a0b<\/strong><\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u7533\u8bf7\u65b9\u5f0f<\/strong>\uff1a\u5728\u7ebf\u7533\u8bf7\u6216\u524d\u5f80\u533b\u7597\u673a\u6784\u7533\u8bf7\u57fa\u56e0\u68c0\u6d4b\u3002<\/li>\n\n\n\n<li><strong>\u6837\u672c\u91c7\u96c6<\/strong>\uff1a\u4f7f\u7528\u7279\u6b8a\u5957\u4ef6\u91c7\u96c6\u553e\u6db2\u548c\u9762\u988a\u7c98\u819c\u3002<\/li>\n\n\n\n<li><strong>\u53d1\u9001<\/strong>\uff1a\u5c06\u6837\u54c1\u53d1\u9001\u5230\u6d4b\u8bd5\u673a\u6784\u3002<\/li>\n\n\n\n<li><strong>\u5206\u6790<\/strong>\uff1a\u5206\u6790\u4e86ADH1B\u548cALDH2\u7684\u57fa\u56e0\u578b\u3002<\/li>\n\n\n\n<li><strong>\u7ed3\u679c<\/strong>\uff1a\u6d4b\u8bd5\u7ed3\u679c\u5c06\u5728\u51e0\u5468\u540e\u53d1\u9001\u7ed9\u60a8\u3002<\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8-2\u3002\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\u83b7\u5f97\u7684\u4fe1\u606f<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9152\u7cbe\u4ee3\u8c22\u80fd\u529b<\/strong>\uff08ADH1B\u3001ALDH2\u578b\uff09<\/li>\n\n\n\n<li><strong>\u996e\u9152\u7684\u5065\u5eb7\u98ce\u9669<\/strong>\uff08\u764c\u75c7\u3001\u809d\u75c5\u3001\u6210\u763e\u98ce\u9669\uff09<\/li>\n\n\n\n<li><strong><strong>\u9002\u5f53\u7684\u996e\u9152\u4e60\u60ef\u5efa\u8bae<\/strong><\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>9. \u5982\u4f55\u4f7f\u7528\u57fa\u56e0\u68c0\u6d4b<\/strong><\/strong><\/h2>\n\n\n\n<p>\u6839\u636e\u57fa\u56e0\u68c0\u6d4b\u7684\u7ed3\u679c\uff0c\u60a8\u53ef\u80fd\u80fd\u591f\u6539\u53d8\u751f\u6d3b\u65b9\u5f0f\uff0c\u4f8b\u5982\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>9-1\u3002\u4e86\u89e3\u9002\u5f53\u7684\u996e\u9152\u91cf<\/strong><\/strong><\/h3>\n\n\n\n<p>\u6839\u636e\u81ea\u8eab\u4ee3\u8c22\u9152\u7cbe\u7684\u80fd\u529b\u9009\u62e9\u9002\u91cf\u7684\u996e\u9152\uff0c\u53ef\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u964d\u4f4e\u5065\u5eb7\u98ce\u9669\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>9-2\u3002\u964d\u4f4e\u5065\u5eb7\u98ce\u9669<\/strong><\/strong><\/h3>\n\n\n\n<p>\u7279\u522b\u662f\uff0cALDH2 \u6d3b\u6027\u8f83\u4f4e\u6216\u4e0d\u6d3b\u8dc3\u7684\u4eba\u53ef\u4ee5\u901a\u8fc7\u68c0\u67e5\u996e\u9152\u4e60\u60ef\u6765\u964d\u4f4e\u60a3\u764c\u75c7\u548c\u809d\u75c5\u7684\u98ce\u9669\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9-3. \u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u306e\u4e88\u9632<\/strong><\/h3>\n\n\n\n<p>ADH1B \u6d3b\u6027\u8f83\u4f4e\u7684\u4eba\u53ef\u4ee5\u901a\u8fc7\u9002\u5f53\u7ba1\u7406\u996e\u9152\u4e60\u60ef\u6765\u964d\u4f4e\u6210\u763e\u98ce\u9669\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>10. \u672a\u6765\u7814\u7a76\u4e0e\u5c55\u671b<\/strong><\/strong><\/h2>\n\n\n\n<p>\u968f\u7740\u57fa\u56e0\u7814\u7a76\u7684\u4e0d\u65ad\u8fdb\u6b65\uff0c\u6709\u5173\u9152\u7cbe\u4ee3\u8c22\u7684\u65b0\u53d1\u73b0\u4e0d\u65ad\u88ab\u53d1\u8868\u3002\u4ee5\u4e0b\u4e3b\u9898\u662f\u672a\u6765\u7814\u7a76\u7684\u91cd\u70b9\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u53d1\u73b0\u65b0\u7684\u57fa\u56e0\u6807\u8bb0<\/strong>\uff1a\u9664ADH1B\u548cALDH2\u4e4b\u5916\u7684\u57fa\u56e0\u4e5f\u53ef\u80fd\u53c2\u4e0e\u9152\u7cbe\u4ee3\u8c22\u3002<\/li>\n\n\n\n<li><strong>\u4e2a\u6027\u5316\u533b\u7597\u7684\u53d1\u5c55<\/strong>\uff1a\u6839\u636e\u57fa\u56e0\u578b\u5236\u5b9a\u4e2a\u6027\u5316\u996e\u9152\u5efa\u8bae\u3002<\/li>\n\n\n\n<li><strong>\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5<\/strong>\uff1a\u57fa\u56e0\u7597\u6cd5\u9884\u9632\u548c\u6cbb\u7597\u9152\u7cbe\u4e2d\u6bd2\u7684\u6f5c\u529b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>11. \u9152\u7cbe\u4ee3\u8c22\u57fa\u56e0\u7684\u5168\u7403\u5206\u5e03<\/strong><\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/1177088_m-1024x683.jpg\" alt=\"\" class=\"wp-image-7103\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1177088_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1177088_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1177088_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1177088_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/1177088_m.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u4e0d\u540c\u79cd\u65cf\u548c\u5730\u533a\u7684\u4eba\u4ee3\u8c22\u9152\u7cbe\u7684\u80fd\u529b\u5b58\u5728\u5f88\u5927\u5dee\u5f02\u3002\u8fd9\u662f\u7531\u4e8e\u9057\u4f20\u56e0\u7d20\u9020\u6210\u7684\uff0c<strong>\u67d0\u4e9b\u57fa\u56e0\u578b\u5728\u67d0\u4e9b\u5730\u533a\u66f4\u4e3a\u666e\u904d<\/strong>\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>11-1\u3002\u4e1c\u4e9a\u4eba\u7684\u57fa\u56e0\u7279\u5f81<\/strong><\/strong><\/h3>\n\n\n\n<p>\u5df2\u77e5\u5728\u4e1c\u4e9a\u5730\u533a\uff08\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u97e9\u56fd\uff09\uff0c<strong>ALDH2\u6d3b\u6027\u4f4e\u6216\u4e0d\u6d3b\u8dc3\u7684\u4eba\u7fa4\u6bd4\u4f8b\u975e\u5e38\u9ad8\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>ALDH2\u57fa\u56e0\u5728\u4e1c\u4e9a\u4eba\u7fa4\u4e2d\u7684\u5206\u5e03<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**ALDH2 \u6d3b\u6027\u7c7b\u578b\uff08ALDH2\u00a0<em>1\/1\uff09\uff1a\u7ea6 55-60%<\/em><\/li>\n\n\n\n<li>**ALDH2 \u4f4e\u6d3b\u6027\u578b\uff08ALDH2\u00a0<em>1\/2\uff09\uff1a\u7ea6 35-40%<\/em><\/li>\n\n\n\n<li>**ALDH2 \u975e\u6d3b\u6027\u578b\uff08ALDH2\u00a0<em>2\/2\uff09\uff1a\u7ea6 5%<\/em><\/li>\n<\/ul>\n\n\n\n<p>\u4e1c\u4e9a\u4eba\u66f4\u5bb9\u6613\u51fa\u73b0 ALDH2 \u6d3b\u6027\u4f4e\u7684\u539f\u56e0\u88ab\u8ba4\u4e3a\u662f\u7531\u4e8e\u7279\u5b9a\u7684\u57fa\u56e0\u7a81\u53d8\u5728\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u56fa\u5b9a\u4e0b\u6765\u3002\u7279\u522b\u662f\uff0c\u6709\u4eba\u63d0\u51fa<strong>\u5386\u53f2\u4e0a\u6444\u5165\u5927\u91cf\u53d1\u9175\u98df\u54c1\u53ef\u80fd\u4e0e\u6b64\u6709\u5173\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>11-2\u3002\u897f\u65b9\u4eba\u7684\u57fa\u56e0\u7279\u5f81<\/strong><\/strong><\/h3>\n\n\n\n<p>\u897f\u65b9\u4eba\uff08\u6b27\u6d32\u4eba\u548c\u7f8e\u56fd\u4eba\uff09\u7684\u7279\u70b9\u662f<strong>\u51e0\u4e4e\u6ca1\u6709\u4f4e\u6d3b\u6027\u6216\u4e0d\u6d3b\u6027\u7684ALDH2 \u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u897f\u65b9\u4ebaALDH2\u57fa\u56e0\u7684\u5206\u5e03<\/strong><\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**ALDH2 \u6d3b\u6027\u7c7b\u578b\uff08ALDH2\u00a0<em>1\/1\uff09\uff1a99% \u6216\u66f4\u591a<\/em><\/li>\n\n\n\n<li>**ALDH2 \u4f4e\u6d3b\u6027\u578b\uff08ALDH2\u00a0<em>1\/2\uff09\uff1a1% \u6216\u66f4\u4f4e<\/em><\/li>\n\n\n\n<li>**\u975e\u6d3b\u6027 ALDH2\uff08ALDH2\u00a0<em>2\/2\uff09\uff1a\u51e0\u4e4e\u4e3a\u96f6<\/em><\/li>\n<\/ul>\n\n\n\n<p>\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48\u897f\u65b9\u4eba\u5bf9\u9152\u7cbe\u7684\u8010\u53d7\u6027\u66f4\u9ad8\u3002\u4f46\u662f\uff0c\u7531\u4e8eADH1B\u6d3b\u6027\u8f83\u4f4e\uff08ADH1B*1\/*1\uff09\u7684\u4eba\u8f83\u591a\uff0c\u56e0\u6b64<strong>\u4ed6\u4eec\u66f4\u5bb9\u6613\u51fa\u73b0\u9152\u7cbe\u4f9d\u8d56\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>11-3\u3002\u975e\u6d32\u3001\u4e2d\u4e1c\u548c\u5357\u4e9a\u7684\u9057\u4f20\u7279\u5f81<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u975e\u6d32\u88d4\u4eba\u7fa4<\/strong>\uff1a\u4ed6\u4eec\u5177\u6709\u8f83\u9ad8\u7684\u9ad8\u6d3b\u6027ADH1B\u53d1\u751f\u7387\uff0c\u8fd9\u4f7f\u5f97\u4ed6\u4eec\u80fd\u591f\u5feb\u901f\u5206\u89e3\u9152\u7cbe\uff0c\u4ece\u800c\u964d\u4f4e\u6210\u763e\u98ce\u9669\u3002<\/li>\n\n\n\n<li><strong>\u4e2d\u4e1c\u6216\u5370\u5ea6\u8840\u7edf\u7684\u4eba<\/strong>\uff1a\u57fa\u56e0\u578b\u56e0\u5730\u533a\u800c\u5f02\uff0c\u4f46 ADH1B \u4f4e\u6d3b\u6027\u57fa\u56e0\u578b\u7684\u6bd4\u4f8b\u76f8\u5bf9\u8f83\u9ad8\u3002<\/li>\n\n\n\n<li><strong>\u4e1c\u5357\u4e9a\uff08\u6cf0\u56fd\u3001\u8d8a\u5357\u3001\u83f2\u5f8b\u5bbe\u7b49\uff09<\/strong>\uff1a\u90e8\u5206\u4eba\u7fa4\u5b58\u5728ALDH2\u6d3b\u6027\u4f4e\u7684\u60c5\u51b5\uff0c\u4f46\u4e0d\u50cf\u4e1c\u4e9a\u90a3\u4e48\u5e38\u89c1\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>12. \u57fa\u56e0\u578b\u4e0e\u9152\u7cbe\u654f\u611f\u6027\u7684\u5173\u7cfb<\/strong><\/strong><\/h2>\n\n\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-1024x683.jpg\" alt=\"\" class=\"wp-image-7116\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m-1536x1025.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/4564629_m.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u9152\u7cbe\u5bf9\u4e0d\u540c\u57fa\u56e0\u578b\u7684\u4eba\u7684\u5f71\u54cd\u4e0d\u540c\u3002\u5b83\u4eec\u5206\u4e3a\u4ee5\u4e0b\u7c7b\u578b\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-1\u3002\u9ad8\u8010\u9152\u7cbe\u578b<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**ADH1B\u4f4e\u6d3b\u6027\u578b\uff08ADH1B\u00a0<em>1\/1\uff09+ ALDH2\u6d3b\u6027\u578b\uff08ALDH21\/1\uff09<\/em><\/li>\n\n\n\n<li>\u5b83\u4f1a\u7f13\u6162\u5730\u5206\u89e3\u9152\u7cbe\uff0c\u6240\u4ee5\u4f60\u4e0d\u4f1a\u8f7b\u6613\u9189\u9152\u3002<\/li>\n\n\n\n<li>\u6210\u763e\u98ce\u9669\u9ad8<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-2\u3002\u5bf9\u9152\u7cbe\u6709\u8f7b\u5fae\u8010\u53d7\u6027<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**ADH1B \u9ad8\u6d3b\u6027\u578b\uff08ADH1B\u00a0<em>2\/2\uff09+ ALDH2 \u6d3b\u6027\u578b\uff08ALDH21\/1\uff09<\/em><\/li>\n\n\n\n<li>\u9152\u7cbe\u5206\u89e3\u5f88\u5feb\uff0c\u4f46\u4e0d\u53d7\u4e59\u919b\u7684\u5f71\u54cd<\/li>\n\n\n\n<li>\u559d\u5b8c\u8138\u4e0d\u4f1a\u7ea2\uff0c\u53ef\u4ee5\u5b89\u5fc3\u559d\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-3\u3002\u5bf9\u9152\u7cbe\u654f\u611f\u7684\u4eba<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**ADH1B \u9ad8\u6d3b\u6027\u578b\uff08ADH1B\u00a0<em>2\/2\uff09+ ALDH2 \u4f4e\u6d3b\u6027\u578b\uff08ALDH21\/2\uff09<\/em><\/li>\n\n\n\n<li>\u4e59\u919b\u5206\u89e3\u8f83\u6162\uff0c\u6240\u4ee5\u559d\u9152\u540e\u8138\u5f88\u5feb\u5c31\u4f1a\u53d8\u7ea2\u3002<\/li>\n\n\n\n<li>\u996e\u9152\u589e\u52a0\u98df\u9053\u764c\u98ce\u9669<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>12-4\u3002\u51e0\u4e4e\u65e0\u6cd5\u5fcd\u53d7\u9152\u7cbe\u7684\u4eba<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>**ADH1B \u9ad8\u6d3b\u6027\u578b\uff08ADH1B\u00a0<em>2\/2\uff09+ ALDH2 \u975e\u6d3b\u6027\u578b\uff08ALDH22\/2\uff09<\/em><\/li>\n\n\n\n<li>\u5373\u4f7f\u5c11\u91cf\u7684\u9152\u7cbe\u4e5f\u4f1a\u5f15\u8d77\u5fc3\u60b8\u548c\u6076\u5fc3<\/li>\n\n\n\n<li>\u6211\u51e0\u4e4e\u4e0d\u80fd\u5fcd\u53d7\u9152\u7cbe<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>13. \u5229\u7528\u57fa\u56e0\u68c0\u6d4b\u8fdb\u884c\u5065\u5eb7\u7ba1\u7406<\/strong><\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>13-1\u3002\u57fa\u4e8e\u57fa\u56e0\u578b\u7684\u996e\u9152\u89c4\u5219<\/strong><\/strong><\/h3>\n\n\n\n<p>\u6839\u636e\u60a8\u7684\u57fa\u56e0\u6d4b\u8bd5\u7ed3\u679c\uff0c\u60a8\u53ef\u80fd\u53ef\u4ee5\u5236\u5b9a\u996e\u9152\u89c4\u5219\uff0c\u4f8b\u5982\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong><strong>\u57fa\u56e0\u578b<\/strong><\/strong><\/td><td><strong><strong>\u5efa\u8bae\u996e\u9152\u89c4\u5219<\/strong><\/strong><\/td><\/tr><tr><td><strong><strong>ALDH2\u6d3b\u6027\u578b+ADH1B\u4f4e\u6d3b\u6027\u578b<\/strong><\/strong><\/td><td>\u907f\u514d\u8fc7\u91cf\u996e\u9152\u5e76\u6ce8\u610f\u6210\u763e\u98ce\u9669<\/td><\/tr><tr><td><strong><strong>ALDH2\u6d3b\u6027\u578b+ADH1B\u9ad8\u6d3b\u6027\u578b<\/strong><\/strong><\/td><td>\u5141\u8bb8\u9002\u91cf\u996e\u9152<\/td><\/tr><tr><td><strong><strong>ALDH2\u4f4e\u6d3b\u6027\u578b<\/strong><\/strong><\/td><td>\u51cf\u5c11\u996e\u9152\u5e76\u5b9a\u671f\u8fdb\u884c\u5065\u5eb7\u68c0\u67e5<\/td><\/tr><tr><td><strong><strong>ALDH2\u975e\u6d3b\u6027\u578b<\/strong><\/strong><\/td><td>\u5efa\u8bae\u6212\u9152<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>13-2\u3002\u9884\u9632\u533b\u5b66\u7684\u5e94\u7528<\/strong><\/strong><\/h3>\n\n\n\n<p>\u5229\u7528\u57fa\u56e0\u68c0\u6d4b\u7684\u4fe1\u606f\u53ef\u4ee5\u5b9e\u73b0\u4ee5\u4e0b\u9884\u9632\u6027\u533b\u7597\u6cbb\u7597\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9152\u7cbe\u76f8\u5173\u764c\u75c7\u7684\u65e9\u671f\u53d1\u73b0<\/strong>\uff1aALDH2 \u6d3b\u6027\u4f4e\u7684\u4eba\u5e94\u5b9a\u671f\u63a5\u53d7\u5185\u7aa5\u955c\u68c0\u67e5\u3002<\/li>\n\n\n\n<li><strong>\u517b\u6210\u8fdb\u884c\u809d\u529f\u80fd\u68c0\u67e5\u7684\u4e60\u60ef<\/strong>\uff1a\u5177\u6709\u5bf9\u809d\u810f\u9020\u6210\u538b\u529b\u7684\u9057\u4f20\u7c7b\u578b\u7684\u4eba\u5e94\u8be5\u5b9a\u671f\u8fdb\u884c\u8840\u6db2\u68c0\u67e5\u3002<\/li>\n\n\n\n<li><strong>\u9884\u9632\u6210\u763e<\/strong>\uff1aADH1B \u6d3b\u6027\u4f4e\u7684\u4eba\u5b66\u4f1a\u63a7\u5236\u81ea\u5df1\u7684\u996e\u9152\u4e60\u60ef\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>14. \u672a\u6765\u7684\u57fa\u56e0\u7814\u7a76\u548c\u9152\u7cbe\u4ee3\u8c22<\/strong><\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"796\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-1024x796.jpg\" alt=\"\u7814\u7a76\u5ba4\u3000\u5973\u6027\" class=\"wp-image-7704\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-1024x796.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-300x233.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-768x597.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m-1536x1194.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/31989205_m.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u57fa\u56e0\u7814\u7a76\u7684\u8fdb\u5c55\uff0c\u4eba\u4eec\u53d1\u73b0\u4e86\u53c2\u4e0e\u9152\u7cbe\u4ee3\u8c22\u7684\u65b0\u57fa\u56e0\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14-1\u3002\u53d1\u73b0\u65b0\u7684\u9057\u4f20\u6807\u8bb0<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CYP2E1\u57fa\u56e0<\/strong>\uff1a\u53c2\u4e0e\u809d\u810f\u4ee3\u8c22\u9152\u7cbe\u7684\u8fc7\u7a0b\u3002<\/li>\n\n\n\n<li><strong>GABRA2 \u57fa\u56e0<\/strong>\uff1a\u4e0e\u9157\u9152\u98ce\u9669\u6709\u5173\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>14-2\u3002\u57fa\u56e0\u6cbb\u7597\u7684\u6f5c\u529b<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u76ee\u524d\u6b63\u5728\u7814\u7a76\u9488\u5bf9 ALDH2 \u529f\u80fd\u4e0d\u6d3b\u8dc3\u4eba\u7fa4\u7684\u6cbb\u7597\u65b9\u6cd5<\/strong>\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5728\u672a\u6765\u51cf\u5c11\u996e\u9152\u7684\u5f71\u54cd\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>15. \u57fa\u4e8e\u57fa\u56e0\u578b\u7684\u996e\u9152\u98ce\u9669\u7ba1\u7406<\/strong><\/strong><\/h2>\n\n\n\n<p>\u901a\u8fc7\u5229\u7528\u57fa\u56e0\u68c0\u6d4b\u7684\u7ed3\u679c\uff0c\u53ef\u4ee5\u57f9\u517b\u6bcf\u4e2a\u4eba\u6700\u4f73\u7684\u996e\u9152\u4e60\u60ef\u3002\u8fd9\u91cc\u6211\u4eec\u5c06<strong>\u9488\u5bf9\u6bcf\u79cd\u57fa\u56e0\u578b\u4ecb\u7ecd\u9002\u5f53\u7684\u996e\u9152\u98ce\u9669\u7ba1\u7406\u65b9\u6cd5\u3002<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong><em>15-1\u3002 ALDH2 \u6d3b\u6027\u4eba\u7fa4<\/em>\uff08ALDH2 1\/1\uff09\u7684\u98ce\u9669\u7ba1\u7406<\/strong><\/strong><\/h3>\n\n\n\n<p>\u62e5\u6709\u8fd9\u79cd\u57fa\u56e0\u578b\u7684\u4eba<strong>\u5f80\u5f80\u5bf9\u9152\u7cbe\u6709\u66f4\u5f3a\u7684\u8010\u53d7\u6027\uff0c<\/strong>\u56e0\u4e3a\u4ed6\u4eec\u53ef\u4ee5\u5feb\u901f\u5206\u89e3\u4e59\u919b\u3002\u7136\u800c\uff0c\u5982\u679c\u4e0d\u5c0f\u5fc3\uff0c\u60a8\u6700\u7ec8\u53ef\u80fd\u4f1a\u559d\u66f4\u591a\u7684\u9152\uff0c\u8fd9\u53ef\u80fd\u4f1a\u589e\u52a0\u957f\u671f\u635f\u5bb3\u5065\u5eb7\u7684\u98ce\u9669\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u5bf9\u7b56<\/strong><\/strong><\/h4>\n\n\n\n<p>\u30fb \u6bcf\u5468\u6709\u4e24\u5929\u65f6\u95f4\u4e0d\u559d\u9152<br>\u30fb \u996e\u9152\u65f6\u8bf7\u591a\u559d\u6c34\uff0c\u4ee5\u51cf\u8f7b\u9152\u7cbe\u7684\u5f71\u54cd<br>\u30fb \u5b9a\u671f\u8fdb\u884c\u809d\u529f\u80fd\u68c0\u67e5\uff08AST\u3001ALT\u3001\u03b3-GTP \u7b49\uff09<br>\u30fb \u6bcf\u65e5\u996e\u9152\u91cf\u9650\u5236\u5728\u4e00\u676f\u4ee5\u4e0b<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>15-2\u3002 ALDH2 \u6d3b\u6027\u4f4e (ALDH2 1\/2)<em>\u4eba\u7fa4\u7684\u98ce\u9669\u7ba1\u7406<\/em><\/strong><\/strong><\/h3>\n\n\n\n<p>\u996e\u7528\u6b64\u7c7b\u9152\u7cbe\u7684\u4eba<strong>\u5728\u996e\u9152\u540e\u66f4\u5bb9\u6613\u8138\u7ea2\uff0c\u56e0\u4e3a\u4ed6\u4eec\u5206\u89e3\u4e59\u919b\u7684\u901f\u5ea6\u8f83\u6162<\/strong>\u3002\u4e59\u919b\u7684\u79ef\u7d2f\u4f1a\u589e\u52a0\u60a3\u764c\u75c7\u7684\u98ce\u9669\uff0c\u56e0\u6b64\u9700\u8981\u8c28\u614e\u7ba1\u7406\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u5bf9\u7b56<\/strong><\/strong><\/h4>\n\n\n\n<p>\u30fb \u9650\u5236\u996e\u9152\u9891\u7387\uff0c\u6bcf\u5468\u4e0d\u8d85\u8fc7\u4e24\u6b21<br>\u30fb \u907f\u514d\u996e\u7528\u70c8\u6027\u9152\uff08\u70e7\u9152\u3001\u5a01\u58eb\u5fcc\u3001\u4f0f\u7279\u52a0\u7b49\uff09\uff0c\u9009\u62e9\u4f4e\u9152\u7cbe \u996e\u6599<br>\u30fb \u7531\u4e8e\u60a8\u60a3\u98df\u9053\u764c\u7684\u98ce\u9669\u8f83\u9ad8\uff0c\u56e0\u6b64 40 \u5c81\u4ee5\u540e\u5e94\u5b9a\u671f\u8fdb\u884c\u5185\u7aa5\u955c\u68c0\u67e5<br>\u30fb \u996e\u9152\u65f6\uff0c\u8bf7\u670d\u7528 B \u65cf\u7ef4\u751f\u7d20\uff08\u5c24\u5176\u662f B1 \u548c B6\uff09\u4ee5\u652f\u6301\u809d\u529f\u80fd<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>15-3\u3002 ALDH2 \u529f\u80fd\u4e0d\u6d3b\u8dc3 (ALDH2 2\/2)<em>\u4eba\u7fa4\u7684\u98ce\u9669\u7ba1\u7406<\/em><\/strong><\/strong><\/h3>\n\n\n\n<p>\u60a3\u6709\u8fd9\u79cd\u9152\u7cbe\u969c\u788d\u7684\u4eba<strong>\u51e0\u4e4e\u5b8c\u5168\u65e0\u6cd5\u5206\u89e3\u4e59\u919b\uff0c<\/strong>\u56e0\u6b64\u996e\u9152\u65f6\u4f1a\u5bf9\u4ed6\u4eec\u7684\u5065\u5eb7\u9020\u6210\u91cd\u5927\u98ce\u9669\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u5bf9\u7b56<\/strong><\/strong><\/h4>\n\n\n\n<p>\u30fb \u4e00\u822c\u5efa\u8bae\u6212\u9152\uff08\u5373\u4f7f\u5c11\u91cf\u996e\u9152\u4e5f\u4f1a\u5bf9\u8eab\u4f53\u6709\u5bb3<br>\u30fb \u5982\u679c\u88ab\u8feb\u996e\u9152\uff0c\u8bf7\u4f7f\u7528\u4e0d\u542b\u9152\u7cbe\u7684\u996e\u6599<br>\u30fb \u5b9a\u671f\u8fdb\u884c\u809d\u810f\u548c\u98df\u9053\u68c0\u67e5\uff08\u764c\u75c7\u98ce\u9669\u7ba1\u7406\uff09<br>\u30fb \u4e0e\u5bb6\u4eba\u548c\u533b\u751f\u534f\u5546\uff0c\u5efa\u7acb\u4e0d\u996e\u9152\u7684\u751f\u6d3b\u65b9\u5f0f<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>16. \u57fa\u56e0\u578b\u4e0e\u9152\u7cbe\u6444\u5165\u91cf\u7684\u5173\u7cfb<\/strong><\/strong><\/h2>\n\n\n\n<p>\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c<strong>\u5929\u7136\u9152\u7cbe\u6444\u5165\u91cf\u56e0\u57fa\u56e0\u578b\u800c\u5f02\u3002<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong><strong>\u57fa\u56e0\u578b<\/strong><\/strong><\/td><td><strong><strong>\u6bcf\u5468\u5e73\u5747\u996e\u9152\u91cf<\/strong><\/strong><\/td><td><strong><strong>\u5065\u5eb7\u98ce\u9669<\/strong><\/strong><\/td><\/tr><tr><td><strong><strong>ALDH2\u6d3b\u6027\u578b+ADH1B\u4f4e\u6d3b\u6027\u578b<\/strong><\/strong><\/td><td>\u9ad8\uff08\u7ea6 14 \u81f3 21 \u4e2a\u5355\u4f4d\uff09<\/td><td>\u809d\u786c\u5316\u548c\u6210\u763e\u98ce\u9669\u9ad8<\/td><\/tr><tr><td><strong><strong>ALDH2\u6d3b\u6027\u578b+ADH1B\u9ad8\u6d3b\u6027\u578b<\/strong><\/strong><\/td><td>\u4e2d\u7b49\uff08\u7ea67-14\u4e2a\u5355\u4f4d\uff09<\/td><td>\u5141\u8bb8\u9002\u91cf\u996e\u9152<\/td><\/tr><tr><td><strong><strong>ALDH2\u4f4e\u6d3b\u6027\u578b<\/strong><\/strong><\/td><td>\u4f4e\uff08\u7ea6 3 \u81f3 7 \u4e2a\u5355\u4f4d\uff09<\/td><td>\u5373\u4f7f\u5c11\u91cf\u4e5f\u4f1a\u6709\u5f88\u9ad8\u7684\u81f4\u764c\u98ce\u9669<\/td><\/tr><tr><td><strong><strong>ALDH2\u975e\u6d3b\u6027\u578b<\/strong><\/strong><\/td><td>\u51e0\u4e4e\u4e3a\u96f6<\/td><td>\u5efa\u8bae\u6212\u9152<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><em>\uff081 \u5355\u4f4d = \u7ea6 1 \u676f\u6e05\u9152\u6216 1 \u4e2d\u676f\u5564\u9152\uff09<\/em><\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c\u81ea\u7136\u7684\u996e\u9152\u503e\u5411\u56e0\u57fa\u56e0\u578b\u800c\u5f02\uff0c\u56e0\u6b64<strong>\u6839\u636e\u57fa\u56e0\u68c0\u6d4b\u7684\u7ed3\u679c\u517b\u6210\u9002\u5f53\u7684\u996e\u9152\u4e60\u60ef\u975e\u5e38\u91cd\u8981<\/strong>\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>17. \u8003\u8651\u57fa\u56e0\u578b\u7684\u6539\u5584\u9152\u7cbe\u4ee3\u8c22\u7684\u65b9\u6cd5<\/strong><\/strong><\/h2>\n\n\n\n<p>\u867d\u7136\u9152\u7cbe\u4ee3\u8c22\u80fd\u529b\u662f\u7531\u57fa\u56e0\u578b\u51b3\u5b9a\u7684\uff0c<strong>\u4f46\u901a\u8fc7\u6539\u5584\u751f\u6d3b\u4e60\u60ef\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u63d0\u9ad8\u4ee3\u8c22\u80fd\u529b<\/strong>\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>17-1\u3002\u589e\u5f3a\u8eab\u4f53\u6392\u6bd2\u529f\u80fd\u7684\u8425\u517b\u7d20<\/strong><\/strong><\/h3>\n\n\n\n<p>\u60a8\u53ef\u4ee5\u901a\u8fc7\u79ef\u6781\u6444\u5165\u6709\u52a9\u4e8e\u5206\u89e3\u9152\u7cbe\u7684\u9176\u7684\u8425\u517b\u7269\u8d28\u6765<strong>\u51cf\u8f7b\u996e\u9152\u9020\u6210\u7684\u8d1f\u62c5\u3002<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><strong>\u6539\u5584\u809d\u529f\u80fd\u7684\u8425\u517b\u7d20\u548c\u98df\u7269<\/strong><\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong><strong>\u8425\u517b<\/strong><\/strong><\/td><td><strong><strong>\u5f71\u54cd<\/strong><\/strong><\/td><td><strong><strong>\u5305\u542b\u7684\u98df\u7269<\/strong><\/strong><\/td><\/tr><tr><td>\u7ef4\u751f\u7d20B1<\/td><td>\u652f\u6301\u9152\u7cbe\u5206\u89e3<\/td><td>\u732a\u8089\u3001\u7cd9\u7c73\u3001\u5927\u8c46<\/td><\/tr><tr><td>\u7ef4\u751f\u7d20B6<\/td><td>\u6539\u5584\u809d\u529f\u80fd<\/td><td>\u9999\u8549\u3001\u575a\u679c\u3001\u9e21\u8089<\/td><\/tr><tr><td>\u534a\u80f1\u6c28\u9178<\/td><td>\u52a0\u901f\u9152\u7cbe\u5206\u89e3<\/td><td>\u9e21\u86cb\u3001\u5927\u849c\u3001\u6d0b\u8471<\/td><\/tr><tr><td>\u59dc\u9ec4\u7d20<\/td><td>\u6291\u5236\u809d\u810f\u708e\u75c7<\/td><td>\u59dc\u9ec4<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>17-2\u3002\u51cf\u5c11\u9152\u7cbe\u5f71\u54cd\u7684\u751f\u6d3b\u4e60\u60ef<\/strong><\/strong><\/h3>\n\n\n\n<p>\u4e3a\u4e86\u5c3d\u91cf\u51cf\u5c11\u9152\u7cbe\u7684\u5f71\u54cd\uff0c\u8bf7\u5c1d\u8bd5\u9075\u5faa\u4ee5\u4e0b\u4e60\u60ef\uff1a<\/p>\n\n\n\n<p>\u30fb <strong>\u996e\u9152\u524d\u8bf7\u591a\u559d\u6c34<\/strong>\uff08\u9632\u6b62\u8131\u6c34\uff09<br>\u30fb <strong>\u907f\u514d\u7a7a\u8179\u996e\u9152<\/strong>\uff08\u51cf\u8f7b\u80c3\u90e8\u8d1f\u62c5\uff09<br>\u30fb <strong>\u996e\u9152\u540e\u8bf7\u4fdd\u8bc1\u5145\u8db3\u7684\u7761\u7720<\/strong>\uff08\u4fc3\u8fdb\u809d\u810f\u6062\u590d\uff09<br>\u30fb <strong>\u996e\u9152\u540e\u8bf7\u907f\u514d\u8fd0\u52a8<\/strong>\uff08\u51cf\u8f7b\u809d\u810f\u8d1f\u62c5\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong>18. \u57fa\u56e0\u68c0\u6d4b\u548c\u4e2a\u6027\u5316\u533b\u7597\u7684\u672a\u6765<\/strong><\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"724\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/22471033_m-1024x724.jpg\" alt=\"\u30c7\u30b8\u30bf\u30eb\u3068\u672a\u6765\u306e\u30a4\u30e1\u30fc\u30b8\" class=\"wp-image-7516\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22471033_m-1024x724.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22471033_m-300x212.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22471033_m-768x543.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22471033_m-1536x1086.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/22471033_m.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u968f\u7740\u57fa\u56e0\u7814\u7a76\u7684\u6700\u65b0\u8fdb\u5c55\uff0c<strong>\u4e2a\u6027\u5316\u533b\u7597\u53d8\u5f97\u8d8a\u6765\u8d8a\u91cd\u8981<\/strong>\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>18-1\u3002\u5229\u7528\u57fa\u56e0\u4fe1\u606f\u8fdb\u884c\u996e\u9152\u98ce\u9669\u7ba1\u7406<\/strong><\/strong><\/h3>\n\n\n\n<p>\u5c06\u6765\uff0c\u5f88\u53ef\u80fd<strong>\u4f1a\u6839\u636e\u4e2a\u4eba\u7684\u57fa\u56e0\u578b\u6765\u5efa\u8bae\u6700\u4f73\u7684\u996e\u9152\u4e60\u60ef\u548c\u5065\u5eb7\u7ba1\u7406\u65b9\u6cd5\u3002<\/strong><\/p>\n\n\n\n<p><strong><strong>\u6f5c\u5728\u7684\u6280\u672f\u521b\u65b0<\/strong><br><\/strong>\u30fb \u901a\u8fc7\u667a\u80fd\u624b\u673a\u5e94\u7528\u7a0b\u5e8f\u63d0\u4f9b\u9488\u5bf9\u7279\u5b9a\u57fa\u56e0\u578b\u7684\u996e\u9152\u5efa\u8bae<br>\u30fb \u901a\u8fc7\u53ef\u7a7f\u6234\u8bbe\u5907\u5b9e\u65f6\u76d1\u6d4b\u9152\u7cbe\u4ee3\u8c22<br>\u30fb \u4f7f\u7528\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5f00\u53d1\u975e\u6d3b\u6027 ALDH2 \u6cbb\u7597\u65b9\u6cd5<\/p>\n\n\n\n<p>\u968f\u7740\u8fd9\u4e9b\u6280\u672f\u7684\u53d1\u5c55\uff0c<strong>\u66f4\u5b89\u5168\u3001\u66f4\u5065\u5eb7\u7684\u996e\u9152\u4e60\u60ef\u5c06\u6210\u4e3a\u53ef\u80fd<\/strong>\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>\u6982\u62ec<\/strong><\/strong><\/h3>\n\n\n\n<p>\u4ee3\u8c22\u9152\u7cbe\u7684\u80fd\u529b\u5f88\u5927\u7a0b\u5ea6\u4e0a\u7531\u4e24\u4e2a\u57fa\u56e0\u51b3\u5b9a\uff0c\u5373<strong>ADH1B<\/strong>\u548c<strong>ALDH2<\/strong>&nbsp;\u3002\u636e\u4e86\u89e3\uff0c<strong>ALDH2\u6d3b\u6027\u8f83\u4f4e\u6216\u4e0d\u6d3b\u8dc3\u7684\u4eba\u5728\u996e\u9152\u540e\uff0c\u7531\u4e8e\u4e59\u919b\u7684\u79ef\u7d2f\uff0c\u66f4\u5bb9\u6613\u51fa\u73b0\u8138\u7ea2\u7684\u60c5\u51b5\uff0c\u5e76\u4e14\u7f79\u60a3\u764c\u75c7\u7684\u98ce\u9669\u4e5f\u66f4\u9ad8<\/strong>\u3002\u53e6\u4e00\u65b9\u9762\uff0c ADH1B \u6d3b\u6027\u8f83\u4f4e\u7684\u4eba\u4e0d\u592a\u53ef\u80fd\u559d\u9189\uff0c\u5e76\u4e14\u5f80\u5f80<strong>\u66f4\u5bb9\u6613\u4ea7\u751f\u9152\u7cbe\u4f9d\u8d56\u3002<\/strong><\/p>\n\n\n\n<p>\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\uff0c<strong>\u53ef\u4ee5\u6b63\u786e\u4e86\u89e3\u81ea\u8eab\u7684\u9152\u7cbe\u8010\u53d7\u6027\uff0c\u5efa\u7acb\u9002\u5f53\u7684\u996e\u9152\u4e60\u60ef\uff0c\u4fdd\u62a4\u81ea\u8eab\u7684\u5065\u5eb7<\/strong>\u3002\u672a\u6765\uff0c\u4e2a\u6027\u5316\u533b\u7597\u7684\u8fdb\u6b65\u5c06\u5b9e\u73b0\u66f4\u7cbe\u51c6\u7684\u98ce\u9669\u7ba1\u7406\u3002<a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/p>\n\n\n\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u56e0\u4e0e\u9152\u7cbe\u4ee3\u8c22\u7684\u5173\u7cfb \u996e\u9152\u540e\uff0c\u9152\u7cbe\u5728\u4f53\u5185\u5206\u89e3\u7684\u901f\u5ea6\u4ee5\u53ca\u5bf9\u8eab\u4f53\u7684\u5f71\u54cd\u56e0\u4eba\u800c\u5f02\u3002\u9020\u6210\u8fd9\u79cd\u5dee\u5f02\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u662f\u57fa\u56e0\u3002\u6700\u8fd1\u7684\u57fa\u56e0\u7814\u7a76\u8868\u660e\uff0c\u4ee3\u8c22\u9152\u7cbe\u7684\u80fd\u529b\u662f\u7531\u57fa\u56e0\u51b3\u5b9a\u7684\u3002\u7279\u522b\u662f\u5c06\u9152\u7cbe\u5206\u89e3\u4e3a\u4e59\u919b\u7684ADH1B\u57fa\u56e0\u548c\u5c06\u4e59\u919b\u8f6c\u5316\u4e3a\u4e59\u9178\u7684A [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":4190,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[203],"tags":[],"class_list":["post-15442","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-basicknowledge-zh-hans"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/15442","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/comments?post=15442"}],"version-history":[{"count":1,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/15442\/revisions"}],"predecessor-version":[{"id":15447,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/posts\/15442\/revisions\/15447"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media\/4190"}],"wp:attachment":[{"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/media?parent=15442"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/categories?post=15442"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-json\/wp\/v2\/tags?post=15442"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}