{"id":1673,"date":"2025-01-13T02:10:25","date_gmt":"2025-01-13T02:10:25","guid":{"rendered":"https:\/\/www.hiro-clinic.or.jp\/gene\/?p=1673"},"modified":"2025-02-13T07:37:54","modified_gmt":"2025-02-13T07:37:54","slug":"%e9%81%ba%e4%bc%9d%e5%ad%90%e6%83%85%e5%a0%b1%e3%81%a7%e8%a6%8b%e3%82%8b%e9%aa%a8%e6%a0%bc%e7%ad%8b%e3%81%ae%e7%99%ba%e9%81%94%e3%81%a8%e9%81%8b%e5%8b%95%e7%bf%92%e6%85%a3","status":"publish","type":"post","link":"https:\/\/www.hiro-clinic.or.jp\/gene\/%e9%81%ba%e4%bc%9d%e5%ad%90%e6%83%85%e5%a0%b1%e3%81%a7%e8%a6%8b%e3%82%8b%e9%aa%a8%e6%a0%bc%e7%ad%8b%e3%81%ae%e7%99%ba%e9%81%94%e3%81%a8%e9%81%8b%e5%8b%95%e7%bf%92%e6%85%a3\/","title":{"rendered":"\u907a\u4f1d\u5b50\u60c5\u5831\u3067\u898b\u308b\u9aa8\u683c\u7b4b\u306e\u767a\u9054\u3068\u904b\u52d5\u7fd2\u6163"},"content":{"rendered":"\n<p>\u7b4b\u8089\u306e\u767a\u9054\u3084\u904b\u52d5\u306e\u52b9\u679c\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u9055\u3044\u3092\u751f\u3080\u5927\u304d\u306a\u8981\u56e0\u306e\u3072\u3068\u3064\u304c\u300c\u907a\u4f1d\u5b50\u300d\u3067\u3059\u3002<strong>\u9aa8\u683c\u7b4b\u306e\u6210\u9577\u901f\u5ea6\u3001\u7b4b\u529b\u306e\u5411\u4e0a\u3001\u6301\u4e45\u529b\u306e\u9ad8\u3055\u306a\u3069\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3068\u74b0\u5883\u8981\u56e0\u304c\u76f8\u4e92\u4f5c\u7528\u3057\u306a\u304c\u3089\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u3002<\/strong> \u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u7b4b\u8089\u306e\u767a\u9054\u3084\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u9069\u5fdc\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001<strong>\u9aa8\u683c\u7b4b\u306e\u767a\u9054\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u3001\u7b4b\u8089\u30bf\u30a4\u30d7\u306e\u9055\u3044\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6700\u9069\u5316\u306e\u65b9\u6cd5\u3001\u6700\u65b0\u306e\u7814\u7a76\u52d5\u5411<\/strong>\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u77e5\u308b\u3053\u3068\u3067\u3001<strong>\u3088\u308a\u52b9\u7387\u7684\u306b\u7b4b\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u6226\u7565\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>1. \u9aa8\u683c\u7b4b\u306e\u767a\u9054\u3068\u907a\u4f1d\u306e\u95a2\u4fc2<\/strong><\/h2>\n\n\n\n<p>\u9aa8\u683c\u7b4b\u306e\u6210\u9577\u306b\u306f\u3001\u7b4b\u7dda\u7dad\u306e\u7a2e\u985e\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3001\u7b4b\u53ce\u7e2e\u306e\u4ed5\u7d44\u307f\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6a5f\u80fd\u306f\u3001<strong>\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b<\/strong>\u3053\u3068\u304c\u7814\u7a76\u306b\u3088\u3063\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20139779\/\">Timmons JA, 2010<\/a>\uff09\u3002<\/p>\n\n\n\n<p><strong>\u9aa8\u683c\u7b4b\u306e\u767a\u9054\u306b\u95a2\u4fc2\u3059\u308b\u4e3b\u306a\u8981\u56e0<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7b4b\u7dda\u7dad\u306e\u7a2e\u985e\uff08\u901f\u7b4b vs. \u9045\u7b4b\uff09<\/strong><\/li>\n\n\n\n<li><strong>\u7b4b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u80fd\u529b<\/strong><\/li>\n\n\n\n<li><strong>\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3084\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5206\u6ccc\u91cf<\/strong><\/li>\n\n\n\n<li><strong>\u9178\u7d20\u4f9b\u7d66\u80fd\u529b\uff08\u6bdb\u7d30\u8840\u7ba1\u5bc6\u5ea6\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6570\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<p>\u7279\u306b\u3001<strong>\u901f\u7b4b\u3068\u9045\u7b4b\u306e\u5272\u5408<\/strong>\u306f\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\u90e8\u5206\u304c\u591a\u304f\u3001<strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u9069\u5fdc\u5ea6\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u9aa8\u683c\u7b4b\u306e\u767a\u9054\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/26304079_m-1024x1024.jpg\" alt=\"\u9aa8\" class=\"wp-image-5080\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/26304079_m-1024x1024.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/26304079_m-300x300.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/26304079_m-150x150.jpg 150w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/26304079_m-768x768.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/26304079_m-1536x1536.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/26304079_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2460 ACTN3\u907a\u4f1d\u5b50\uff08\u901f\u7b4b\u7e4a\u7dad\u3068\u7206\u767a\u7684\u30d1\u30ef\u30fc\uff09<\/strong><\/h3>\n\n\n\n<p>**ACTN3\uff08\u03b1-\u30a2\u30af\u30c1\u30cb\u30f3-3\uff09**\u306f\u3001\u901f\u7b4b\u7dda\u7dad\uff08Type II\uff09\u306e\u767a\u9054\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u4e3b\u306b\u77ed\u8ddd\u96e2\u8d70\u3084\u30d1\u30ef\u30fc\u7cfb\u30b9\u30dd\u30fc\u30c4\u9078\u624b\u306b\u591a\u304f\u898b\u3089\u308c\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18043716\/\">MacArthur DG, 2007<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>R\u578b\uff08RR\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u901f\u7b4b\u304c\u767a\u9054\u3057\u3084\u3059\u304f\u3001\u77ac\u767a\u529b\u304c\u9ad8\u3044\u3002\u30b9\u30d7\u30ea\u30f3\u30c8\u3084\u30a6\u30a7\u30a4\u30c8\u30ea\u30d5\u30c6\u30a3\u30f3\u30b0\u5411\u304d\u3002<\/li>\n\n\n\n<li><strong>X\u578b\uff08XX\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u901f\u7b4b\u306e\u767a\u9054\u304c\u9045\u304f\u3001\u6301\u4e45\u529b\u304c\u9ad8\u3044\u3002\u30de\u30e9\u30bd\u30f3\u3084\u9577\u8ddd\u96e2\u5411\u304d\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>ACTN3\u907a\u4f1d\u5b50\u306b\u3088\u308b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6700\u9069\u5316<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>RR\u578b\u306e\u4eba<\/strong> \u2192 \u77ed\u6642\u9593\u30fb\u9ad8\u8ca0\u8377\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30b9\u30d7\u30ea\u30f3\u30c8\u3001\u30d7\u30e9\u30a4\u30aa\u30e1\u30c8\u30ea\u30af\u30b9\u3001\u91cd\u91cf\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/li>\n\n\n\n<li><strong>XX\u578b\u306e\u4eba<\/strong> \u2192 \u6301\u4e45\u7cfb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u9577\u6642\u9593\u306e\u6709\u9178\u7d20\u904b\u52d5\u3001\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2461 MSTN\u907a\u4f1d\u5b50\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u3068\u7b4b\u8089\u6210\u9577\u306e\u6291\u5236\uff09<\/strong><\/h3>\n\n\n\n<p>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306f\u3001\u7b4b\u8089\u306e\u6210\u9577\u3092\u6291\u5236\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001<strong>MSTN\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u7b4b\u8089\u306e\u767a\u9054\u304c\u4fc3\u9032<\/strong>\u3055\u308c\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15254550\/\">Schuelke M, 2004<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u3044\u4eba<\/strong>\uff1a\u7b4b\u80a5\u5927\u304c\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li><strong>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u5206\u6ccc\u304c\u591a\u3044\u4eba<\/strong>\uff1a\u7b4b\u8089\u306e\u6210\u9577\u304c\u6291\u5236\u3055\u308c\u3084\u3059\u3044<\/li>\n<\/ul>\n\n\n\n<p><strong>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6700\u9069\u5316<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u3044\u4eba<\/strong> \u2192 \u7b4b\u30c8\u30ec\u306e\u52b9\u679c\u304c\u51fa\u3084\u3059\u3044\u305f\u3081\u3001\u9069\u5ea6\u306a\u8ca0\u8377\u3067\u3082\u7b4b\u80a5\u5927\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li><strong>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u5206\u6ccc\u304c\u591a\u3044\u4eba<\/strong> \u2192 \u3088\u308a\u9ad8\u5f37\u5ea6\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u5fc5\u8981\uff088\u301c12\u56de\u306e\u9ad8\u91cd\u91cf\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2462 ACE\u907a\u4f1d\u5b50\uff08\u6301\u4e45\u529b\u3068\u7b4b\u6301\u4e45\u6027\uff09<\/strong><\/h3>\n\n\n\n<p>**ACE\u907a\u4f1d\u5b50\uff08\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\u907a\u4f1d\u5b50\uff09**\u306f\u3001\u6301\u4e45\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u3055\u308c\u3001\u6301\u4e45\u7cfb\u30a2\u30b9\u30ea\u30fc\u30c8\u306b\u304a\u3044\u3066\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u591a\u304f\u898b\u3089\u308c\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9667594\/\">Montgomery HE, 1998<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>I\u578b\uff08II\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u6301\u4e45\u529b\u306b\u512a\u308c\u3001\u30de\u30e9\u30bd\u30f3\u3084\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u5411\u304d<\/li>\n\n\n\n<li><strong>D\u578b\uff08DD\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong>\uff1a\u7b4b\u529b\u3084\u77ac\u767a\u529b\u306b\u512a\u308c\u3001\u30d1\u30ef\u30fc\u7cfb\u30b9\u30dd\u30fc\u30c4\u5411\u304d<\/li>\n<\/ul>\n\n\n\n<p><strong>ACE\u907a\u4f1d\u5b50\u306b\u3088\u308b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6700\u9069\u5316<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>II\u578b\u306e\u4eba<\/strong> \u2192 \u9577\u6642\u9593\u306e\u4f4e\u5f37\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30de\u30e9\u30bd\u30f3\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\uff09<\/li>\n\n\n\n<li><strong>DD\u578b\u306e\u4eba<\/strong> \u2192 \u77ed\u6642\u9593\u30fb\u9ad8\u5f37\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30b9\u30d7\u30ea\u30f3\u30c8\u3001\u91cd\u91cf\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6700\u9069\u5316<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"684\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-1024x684.jpg\" alt=\"\u7b4b\u30c8\u30ec\" class=\"wp-image-3012\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-1024x684.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-768x513.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m-1536x1026.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31381746_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2460 \u7b4b\u80a5\u5927\u3092\u6700\u5927\u5316\u3059\u308b\u305f\u3081\u306e\u6226\u7565<\/strong><\/h3>\n\n\n\n<p>\u2705 <strong>ACTN3\u306eRR\u578b\u306e\u4eba\u306f\u3001\u77ed\u6642\u9593\u30fb\u9ad8\u8ca0\u8377\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u91cd\u8996<\/strong><strong><br><\/strong>\u2705 <strong>MSTN\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u5834\u5408\u3001\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u3092\u6291\u5236\u3059\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff08HMB\u3001\u30af\u30ec\u30a2\u30c1\u30f3\uff09\u304c\u6709\u52b9<\/strong><strong><br><\/strong>\u2705 <strong>ACE\u306eDD\u578b\u306e\u4eba\u306f\u3001\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u6d3b\u7528\u3057\u3066\u6301\u4e45\u529b\u3092\u88dc\u5b8c<\/strong><\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2461 \u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306e\u6226\u7565<\/strong><\/h3>\n\n\n\n<p>\u2705 <strong>ACE\u306eII\u578b\u306e\u4eba\u306f\u3001\u4f4e\u5f37\u5ea6\u306e\u9577\u6642\u9593\u904b\u52d5\u304c\u52b9\u679c\u7684<\/strong><strong><br><\/strong>\u2705 <strong>ACTN3\u306eXX\u578b\u306e\u4eba\u306f\u3001\u7b4b\u6301\u4e45\u529b\u3092\u935b\u3048\u308b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u91cd\u8996<\/strong><strong><br><\/strong>\u2705 <strong>MSTN\u306e\u5f71\u97ff\u304c\u5f37\u3044\u4eba\u306f\u3001\u6709\u9178\u7d20\u904b\u52d5\u306e\u5f8c\u306b\u8efd\u3044\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3046\u3068\u52b9\u679c\u7684<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2462 \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u6804\u990a\u6442\u53d6<\/strong><\/h3>\n\n\n\n<p>\u2705 <strong>\u901f\u7b4b\u304c\u512a\u4f4d\u306a\u4eba\u306f\u3001\u9ad8\u30bf\u30f3\u30d1\u30af\u98df\u3092\u91cd\u8996<\/strong>\uff08\u9d8f\u3080\u306d\u8089\u3001\u5375\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\uff09<br>\u2705 <strong>\u6301\u4e45\u7cfb\u306e\u4eba\u306f\u3001\u70ad\u6c34\u5316\u7269\u306e\u6442\u53d6\u91cf\u3092\u6700\u9069\u5316<\/strong>\uff08\u5168\u7c92\u7c89\u3001\u7384\u7c73\u3001\u30aa\u30fc\u30c8\u30df\u30fc\u30eb\uff09<br>\u2705 <strong>\u7b4b\u8089\u5408\u6210\u3092\u9ad8\u3081\u308b\u305f\u3081\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08\u9b5a\u3001\u30ca\u30c3\u30c4\uff09\u3092\u7a4d\u6975\u7684\u306b\u6442\u308b<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>4. \u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u3068\u672a\u6765\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h2>\n\n\n\n<p>\u8fd1\u5e74\u3001<strong>\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\uff08CRISPR\uff09\u3092\u7528\u3044\u305f\u7b4b\u8089\u5897\u5f37\u306e\u53ef\u80fd\u6027<\/strong>\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5c06\u6765\u7684\u306b\u306f\u3001<strong>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u3092\u6291\u5236\u3059\u308b\u6cbb\u7642\u6cd5<\/strong>\u3084\u3001<strong>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u500b\u5225\u6700\u9069\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u958b\u767a<\/strong>\u304c\u9032\u3080\u3068\u4e88\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3068\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u7d71\u5408\u3057\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u63d0\u6848\u3059\u308b\u30b7\u30b9\u30c6\u30e0<\/strong>\u3082\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6700\u5927\u9650\u306b\u6d3b\u7528\u3057\u306a\u304c\u3089\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u53ef\u80fd\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u500b\u3005\u306e\u4f53\u8cea\u306b\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3084\u6804\u990a\u6226\u7565\u3092\u9078\u629e\u3057\u3001\u3088\u308a\u52b9\u7387\u7684\u306a\u7b4b\u529b\u5411\u4e0a\u3092\u5b9f\u73fe\u3067\u304d\u307e\u3059<\/strong>\u3002\u4eca\u5f8c\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u3088\u308a\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3057\u3001\u3088\u308a\u52b9\u7387\u7684\u306a\u7b4b\u8089\u306e\u767a\u9054\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u3053\u3067\u306f\u3001<strong>\u500b\u3005\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u306b\u5fdc\u3058\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6226\u7565<\/strong>\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2460 \u7b4b\u7dda\u7dad\u30bf\u30a4\u30d7\u5225\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6226\u7565<\/strong><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u901f\u7b4b\u512a\u4f4d\u578b\uff08ACTN3 RR\u578b\uff09<\/strong><\/h4>\n\n\n\n<p>\u901f\u7b4b\u7dda\u7dad\u306f\u3001\u9ad8\u5f37\u5ea6\u3067\u77ed\u6642\u9593\u306e\u904b\u52d5\u306b\u9069\u3057\u3066\u304a\u308a\u3001<strong>\u7206\u767a\u7684\u306a\u30d1\u30ef\u30fc\u3092\u751f\u307f\u51fa\u3059\u306e\u306b\u7279\u5316<\/strong>\u3057\u3066\u3044\u307e\u3059\u3002\u77ed\u8ddd\u96e2\u8d70\u8005\u3084\u30a6\u30a7\u30a4\u30c8\u30ea\u30d5\u30c6\u30a3\u30f3\u30b0\u9078\u624b\u306b\u591a\u304f\u898b\u3089\u308c\u308b\u30bf\u30a4\u30d7\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u63a8\u5968\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u77ed\u6642\u9593\u30fb\u9ad8\u91cd\u91cf\u306e\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30c7\u30c3\u30c9\u30ea\u30d5\u30c8\u3001\u30b9\u30af\u30ef\u30c3\u30c8\u3001\u30d9\u30f3\u30c1\u30d7\u30ec\u30b9\uff081\u30bb\u30c3\u30c86\u56de\u4ee5\u4e0b\u306e\u9ad8\u91cd\u91cf\u8a2d\u5b9a\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30b9\u30d7\u30ea\u30f3\u30c8\u7cfb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a100m\u30c0\u30c3\u30b7\u30e5\u3001\u30d7\u30e9\u30a4\u30aa\u30e1\u30c8\u30ea\u30af\u30b9\uff08\u30dc\u30c3\u30af\u30b9\u30b8\u30e3\u30f3\u30d7\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4f11\u606f\u3092\u9577\u3081\u306b\u3068\u308b<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u901f\u7b4b\u306f\u77ac\u767a\u529b\u3092\u767a\u63ee\u3059\u308b\u304c\u3001\u56de\u5fa9\u304c\u9045\u3044\u305f\u3081\u3001<strong>\u30bb\u30c3\u30c8\u9593\u306e\u4f11\u606f\u30922\uff5e3\u5206\u78ba\u4fdd<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u9045\u7b4b\u512a\u4f4d\u578b\uff08ACTN3 XX\u578b\uff09<\/strong><\/h4>\n\n\n\n<p>\u9045\u7b4b\u7dda\u7dad\u306f\u3001<strong>\u6301\u4e45\u529b\u306b\u512a\u308c\u3001\u9577\u6642\u9593\u306e\u904b\u52d5\u306b\u9069\u5fdc<\/strong>\u3057\u3066\u3044\u307e\u3059\u3002\u9577\u8ddd\u96e2\u30e9\u30f3\u30ca\u30fc\u3084\u30c8\u30e9\u30a4\u30a2\u30b9\u30ed\u30f3\u9078\u624b\u306b\u591a\u3044\u30bf\u30a4\u30d7\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u63a8\u5968\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9577\u6642\u9593\u306e\u6301\u4e45\u7cfb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30de\u30e9\u30bd\u30f3\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\u3001\u30b9\u30a4\u30df\u30f3\u30b0<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4f4e\u91cd\u91cf\u30fb\u9ad8\u56de\u6570\u306e\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30b9\u30af\u30ef\u30c3\u30c8\u3084\u30d9\u30f3\u30c1\u30d7\u30ec\u30b9\u309212\uff5e20\u56de\u306e\u9ad8\u56de\u6570\u3067\u5b9f\u65bd<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30e9\u30f3\u30cb\u30f3\u30b030\u79d2\uff0b\u30a6\u30a9\u30fc\u30af30\u79d2\u3092\u7e70\u308a\u8fd4\u3059HIIT\uff08\u9ad8\u5f37\u5ea6\u30a4\u30f3\u30bf\u30fc\u30d0\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2461 \u7b4b\u80a5\u5927\uff08\u7b4b\u8089\u91cf\u306e\u5897\u52a0\uff09\u3092\u6700\u5927\u5316\u3059\u308b\u65b9\u6cd5<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"681\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/31745016_m-1024x681.jpg\" alt=\"\u7b4b\u8089 \u7537\u6027\" class=\"wp-image-5064\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31745016_m-1024x681.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31745016_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31745016_m-768x511.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31745016_m-1536x1022.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31745016_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u7b4b\u80a5\u5927\u306f\u3001<strong>\u7b4b\u7dda\u7dad\u306e\u5897\u5927\u3068\u7b4b\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306e\u6d3b\u6027\u5316<\/strong>\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u907a\u4f1d\u7684\u306b\u7b4b\u8089\u304c\u3064\u304d\u3084\u3059\u3044\u30bf\u30a4\u30d7\u3068\u3064\u304d\u306b\u304f\u3044\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. MSTN\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u4f4e\u5206\u6ccc\u578b<\/strong><\/h4>\n\n\n\n<p>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306f\u3001\u7b4b\u8089\u306e\u6210\u9577\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u7b4b\u80a5\u5927\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u63a8\u5968\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4f4e\u30ec\u30c3\u30d7\u30fb\u9ad8\u91cd\u91cf\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30b9\u30af\u30ef\u30c3\u30c8\u3001\u30d9\u30f3\u30c1\u30d7\u30ec\u30b9\u3001\u30c7\u30c3\u30c9\u30ea\u30d5\u30c8\u30923\uff5e6\u56de\u306e\u4f4e\u30ec\u30c3\u30d7\u3067\u5b9f\u65bd<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30d7\u30ed\u30c6\u30a4\u30f3\u6442\u53d6\u3092\u6700\u9069\u5316<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u7b4b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c30\u5206\u4ee5\u5185\u306b20\uff5e30g\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6442\u53d6<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u3092\u4fc3\u3059\u305f\u3081\u3001\u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u5bdd\u308b1\u6642\u9593\u524d\u306b\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3092\u907f\u3051\u308b\u3001\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3092\u6442\u53d6<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. MSTN\uff08\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff09\u9ad8\u5206\u6ccc\u578b<\/strong><\/h4>\n\n\n\n<p>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u5206\u6ccc\u304c\u591a\u3044\u4eba\u306f\u3001\u7b4b\u8089\u304c\u3064\u304d\u306b\u304f\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u7b4b\u80a5\u5927\u3092\u4fc3\u9032\u3059\u308b\u305f\u3081\u306b\u3001<strong>\u3088\u308a\u8ca0\u8377\u306e\u9ad8\u3044\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u63a8\u5968\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30c9\u30ed\u30c3\u30d7\u30bb\u30c3\u30c8\u3084\u30b9\u30fc\u30d1\u30fc\u30bb\u30c3\u30c8\u3092\u6d3b\u7528<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30d9\u30f3\u30c1\u30d7\u30ec\u30b9\uff08\u9ad8\u91cd\u91cf6\u56de\uff09\u2192 \u8efd\u91cf\u306b\u5909\u66f4\u3057\u3001\u3055\u3089\u306b10\u56de\u8ffd\u52a0<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>HMB\u3084\u30af\u30ec\u30a2\u30c1\u30f3\u306e\u6d3b\u7528<\/strong>\n<ul class=\"wp-block-list\">\n<li>HMB\uff08\u03b2-\u30d2\u30c9\u30ed\u30ad\u30b7\u03b2-\u30e1\u30c1\u30eb\u916a\u9178\uff09\u306f\u3001\u7b4b\u8089\u5206\u89e3\u3092\u6291\u5236\u3057\u3001\u7b4b\u80a5\u5927\u3092\u4fc3\u9032\u3059\u308b<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30aa\u30fc\u30d0\u30fc\u30ed\u30fc\u30c9\u306e\u539f\u5247\u3092\u91cd\u8996<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u9031\u3054\u3068\u306b\u91cd\u91cf\u3092\u5897\u3084\u3059\u300c\u30d7\u30ed\u30b0\u30ec\u30c3\u30b7\u30d6\u30fb\u30aa\u30fc\u30d0\u30fc\u30ed\u30fc\u30c9\u300d\u3092\u610f\u8b58<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2462 \u7b4b\u529b\u30fb\u30d1\u30ef\u30fc\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h3>\n\n\n\n<p>\u7b4b\u529b\u306e\u5411\u4e0a\u306b\u306f\u3001\u795e\u7d4c\u7cfb\u306e\u9069\u5fdc\u3082\u91cd\u8981\u306a\u8981\u7d20\u3068\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u7684\u306b\u7b4b\u529b\u304c\u767a\u9054\u3057\u3084\u3059\u3044\u30bf\u30a4\u30d7\u3068\u3001\u795e\u7d4c\u7cfb\u306e\u9069\u5fdc\u304c\u5f97\u610f\u306a\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. ACE\u907a\u4f1d\u5b50\uff08\u7b4b\u529b vs. \u6301\u4e45\u529b\uff09<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DD\u578b<\/strong>\uff08\u7b4b\u529b\u30fb\u30d1\u30ef\u30fc\u578b\uff09\uff1a\u77ed\u6642\u9593\u30fb\u9ad8\u5f37\u5ea6\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u9069\u5fdc\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li><strong>II\u578b<\/strong>\uff08\u6301\u4e45\u529b\u578b\uff09\uff1a\u9577\u6642\u9593\u306e\u6301\u4e45\u7cfb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u5f97\u610f<\/li>\n<\/ul>\n\n\n\n<p><strong>ACE DD\u578b\u306e\u4eba\u5411\u3051\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30b9\u30d4\u30fc\u30c9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30b9\u30ec\u30c3\u30c9\u30d7\u30c3\u30b7\u30e5\u3001\u30b9\u30d7\u30ea\u30f3\u30c8\u30c9\u30ea\u30eb<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4f4e\u30ec\u30c3\u30d7\u30fb\u9ad8\u91cd\u91cf\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30af\u30ea\u30fc\u30f3\uff06\u30b8\u30e3\u30fc\u30af\u3001\u30b9\u30ca\u30c3\u30c1<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>ACE II\u578b\u306e\u4eba\u5411\u3051\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6709\u9178\u7d20\u904b\u52d5\uff0b\u8efd\u8ca0\u8377\u306e\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u4f8b\uff1a\u30e9\u30f3\u30cb\u30f3\u30b0\uff0b\u8efd\u3081\u306e\u30a6\u30a7\u30a4\u30c8\u3067\u9ad8\u56de\u6570\u30bb\u30c3\u30c8<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2463 \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u6804\u990a\u6226\u7565<\/strong><\/h3>\n\n\n\n<p>\u7b4b\u8089\u306e\u767a\u9054\u3092\u6700\u5927\u5316\u3059\u308b\u305f\u3081\u306b\u306f\u3001<strong>\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u306b\u5fdc\u3058\u305f\u9069\u5207\u306a\u6804\u990a\u6442\u53d6<\/strong>\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u9ad8\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\u304c\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u578b<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FTO\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong>\uff08\u4ee3\u8b1d\u304c\u4f4e\u304f\u3001\u4f53\u8102\u80aa\u304c\u5897\u3048\u3084\u3059\u3044\uff09\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u30bf\u30f3\u30d1\u30af\u30fb\u4f4e\u8102\u8cea\u306e\u98df\u4e8b\u304c\u9069\u5207<\/strong>\uff08\u9d8f\u3080\u306d\u8089\u3001\u9b5a\u3001\u5375\u767d\uff09<\/li>\n\n\n\n<li><strong>\u30ab\u30fc\u30dc\u30b5\u30a4\u30af\u30eb\uff08\u7cd6\u8cea\u306e\u5468\u671f\u7684\u6442\u53d6\uff09\u3092\u6d3b\u7528<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ACTN3 RR\u578b\u306e\u4eba<\/strong>\uff08\u901f\u7b4b\u512a\u4f4d\u3067\u7206\u767a\u529b\u304c\u3042\u308b\uff09\n<ul class=\"wp-block-list\">\n<li><strong>\u30af\u30ec\u30a2\u30c1\u30f3\u6442\u53d6\u304c\u6709\u52b9<\/strong>\uff08\u7206\u767a\u7684\u30d1\u30ef\u30fc\u3092\u5f37\u5316\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u6301\u4e45\u529b\u5411\u4e0a\u306b\u9069\u3057\u305f\u6804\u990a\u6226\u7565<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ACE II\u578b\u306e\u4eba<\/strong>\uff08\u6301\u4e45\u7cfb\u30a2\u30b9\u30ea\u30fc\u30c8\u5411\u3051\uff09\n<ul class=\"wp-block-list\">\n<li><strong>\u70ad\u6c34\u5316\u7269\u306e\u6442\u53d6\u3092\u6700\u9069\u5316<\/strong>\uff08\u4f4eGI\u98df\u54c1\u3092\u4e2d\u5fc3\u306b\u6442\u308b\uff09<\/li>\n\n\n\n<li><strong>\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6<\/strong>\uff08\u708e\u75c7\u3092\u6291\u3048\u3001\u6301\u4e45\u529b\u5411\u4e0a\u306b\u8ca2\u732e\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u672a\u6765\u3068\u6700\u65b0\u306e\u7814\u7a76\u30c8\u30ec\u30f3\u30c9<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"\/gene\/wp-content\/uploads\/2024\/11\/30342953_s-2.jpg\" alt=\"DNA\u9451\u5b9a\u3092\u3059\u308b\u533b\u5e2b\" class=\"wp-image-2249\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30342953_s-2.jpg 640w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/11\/30342953_s-2-300x200.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001<strong>AI\u3084\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3092\u6d3b\u7528\u3057\u305f\u500b\u5225\u6700\u9069\u5316\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u2460 \u907a\u4f1d\u5b50\u60c5\u5831\u00d7AI\u306e\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3068\u30d5\u30a3\u30c3\u30c8\u30cd\u30b9\u30c8\u30e9\u30c3\u30ab\u30fc\u3092\u7d44\u307f\u5408\u308f\u305b\u3001\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30e9\u30f3\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u63d0\u6848<\/li>\n\n\n\n<li>\u30b9\u30c8\u30ec\u30b9\u30ec\u30d9\u30eb\u3084\u56de\u5fa9\u5ea6\u3092\u89e3\u6790\u3057\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u8ca0\u8377\u3092\u81ea\u52d5\u8abf\u6574<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u2461 \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\uff08CRISPR\uff09\u306b\u3088\u308b\u7b4b\u8089\u5897\u5f37\u306e\u53ef\u80fd\u6027<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u907a\u4f1d\u5b50\u306e\u6539\u5909\u306b\u3088\u308a\u3001\u7b4b\u8089\u306e\u6210\u9577\u3092\u4fc3\u9032\u3059\u308b\u7814\u7a76\u304c\u9032\u884c\u4e2d<\/li>\n\n\n\n<li>\u672a\u6765\u306e\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306b\u5411\u3051\u305f\u502b\u7406\u7684\u306a\u8b70\u8ad6\u3082<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u500b\u3005\u306e\u4f53\u8cea\u306b\u6700\u9069\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3084\u6804\u990a\u6226\u7565\u3092\u9078\u629e\u3057\u3001\u3088\u308a\u52b9\u7387\u7684\u306a\u7b4b\u529b\u5411\u4e0a\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u53d6\u308a\u5165\u308c\u3001\u81ea\u5206\u306e\u907a\u4f1d\u7684\u7279\u6027\u3092\u6700\u5927\u9650\u306b\u6d3b\u304b\u3059\u3053\u3068\u304c\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6210\u679c\u3092\u98db\u8e8d\u7684\u306b\u5411\u4e0a\u3055\u305b\u308b\u9375\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30ea\u30ab\u30d0\u30ea\u30fc\uff08\u56de\u5fa9\uff09\u6226\u7565<\/strong><\/h3>\n\n\n\n<p>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u6301\u4e45\u7cfb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6210\u679c\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u305f\u3081\u306b\u306f\u3001<strong>\u9069\u5207\u306a\u30ea\u30ab\u30d0\u30ea\u30fc\uff08\u56de\u5fa9\uff09\u6226\u7565<\/strong>\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u56de\u5fa9\u901f\u5ea6\u3084\u7b4b\u640d\u50b7\u306e\u30ea\u30b9\u30af\u306b\u5fdc\u3058\u305f\u500b\u5225\u6700\u9069\u5316<\/strong>\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2460 \u907a\u4f1d\u5b50\u3068\u7b4b\u8089\u306e\u56de\u5fa9\u80fd\u529b\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u3001<strong>\u7b4b\u8089\u306e\u4fee\u5fa9\u901f\u5ea6\u3084\u708e\u75c7\u53cd\u5fdc\u306b\u5dee<\/strong>\u304c\u751f\u3058\u307e\u3059\u3002\u7279\u306b\u4ee5\u4e0b\u306e\u907a\u4f1d\u5b50\u306f\u3001\u56de\u5fa9\u529b\u3084\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306e\u75b2\u52b4\u56de\u5fa9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. IL6\u907a\u4f1d\u5b50\uff08\u708e\u75c7\u3068\u56de\u5fa9\u901f\u5ea6\uff09<\/strong><\/h4>\n\n\n\n<p>IL6\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff09\u907a\u4f1d\u5b50\u306f\u3001<strong>\u904b\u52d5\u5f8c\u306e\u708e\u75c7\u53cd\u5fdc\u3084\u7b4b\u4fee\u5fa9\u306b\u95a2\u4e0e<\/strong>\u3057\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16306311\/\">Fischer CP, 2006<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL6\u306e\u767a\u73fe\u304c\u9ad8\u3044\u30bf\u30a4\u30d7<\/strong> \u2192 \u7b4b\u8089\u306e\u708e\u75c7\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u3001\u56de\u5fa9\u306b\u6642\u9593\u304c\u304b\u304b\u308b<\/li>\n\n\n\n<li><strong>IL6\u306e\u767a\u73fe\u304c\u4f4e\u3044\u30bf\u30a4\u30d7<\/strong> \u2192 \u708e\u75c7\u304c\u5c11\u306a\u304f\u3001\u56de\u5fa9\u304c\u65e9\u3044<\/li>\n<\/ul>\n\n\n\n<p><strong>\u56de\u5fa9\u6226\u7565<\/strong>\uff1a \u2705 <strong>\u767a\u73fe\u304c\u9ad8\u3044\u30bf\u30a4\u30d7<\/strong> \u2192 \u6297\u708e\u75c7\u98df\u54c1\uff08\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\u3001\u30b8\u30f3\u30b8\u30e3\u30fc\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff09\u3092\u6442\u53d6\u3057\u3001\u7b4b\u8089\u306e\u708e\u75c7\u3092\u8efd\u6e1b<br>\u2705 <strong>\u767a\u73fe\u304c\u4f4e\u3044\u30bf\u30a4\u30d7<\/strong> \u2192 \u56de\u5fa9\u304c\u65e9\u3044\u305f\u3081\u3001\u77ed\u671f\u9593\u3067\u306e\u9ad8\u983b\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u53ef\u80fd<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. CKM\u907a\u4f1d\u5b50\uff08\u30af\u30ec\u30a2\u30c1\u30f3\u30ad\u30ca\u30fc\u30bc\u3068\u7b4b\u640d\u50b7\uff09<\/strong><\/h4>\n\n\n\n<p>CKM\uff08\u30af\u30ec\u30a2\u30c1\u30f3\u30ad\u30ca\u30fc\u30bc\uff09\u907a\u4f1d\u5b50\u306f\u3001<strong>\u7b4b\u640d\u50b7\u306e\u7a0b\u5ea6\u3084\u56de\u5fa9\u901f\u5ea6\u306b\u5f71\u97ff<\/strong>\u3092\u4e0e\u3048\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17264253\/\">Brancaccio P, 2007<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CKM\u306e\u767a\u73fe\u304c\u9ad8\u3044\u30bf\u30a4\u30d7<\/strong> \u2192 \u7b4b\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u56de\u5fa9\u306b\u6642\u9593\u304c\u304b\u304b\u308b<\/li>\n\n\n\n<li><strong>CKM\u306e\u767a\u73fe\u304c\u4f4e\u3044\u30bf\u30a4\u30d7<\/strong> \u2192 \u7b4b\u640d\u50b7\u304c\u5c11\u306a\u304f\u3001\u65e9\u3044\u56de\u5fa9\u304c\u53ef\u80fd<\/li>\n<\/ul>\n\n\n\n<p><strong>\u56de\u5fa9\u6226\u7565<\/strong>\uff1a \u2705 <strong>\u767a\u73fe\u304c\u9ad8\u3044\u30bf\u30a4\u30d7<\/strong> \u2192 \u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306b<strong>BCAA\uff08\u5206\u5c90\u9396\u30a2\u30df\u30ce\u9178\uff09\u3084HMB<\/strong>\u3092\u6442\u53d6\u3057\u3001\u7b4b\u5206\u89e3\u3092\u9632\u3050<br>\u2705 <strong>\u767a\u73fe\u304c\u4f4e\u3044\u30bf\u30a4\u30d7<\/strong> \u2192 <strong>\u30a2\u30a4\u30b9\u30d0\u30b9\u3084\u4f4e\u6e29\u7642\u6cd5<\/strong>\u3092\u6d3b\u7528\u3057\u3001\u7fcc\u65e5\u306e\u7b4b\u75b2\u52b4\u3092\u8efd\u6e1b<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2461 \u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u5225\u306e\u30ea\u30ab\u30d0\u30ea\u30fc\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/39741_m-1024x683.jpg\" alt=\"DNA\" class=\"wp-image-4930\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/39741_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/39741_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/39741_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/39741_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/39741_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u7684\u306b<strong>\u7b4b\u56de\u5fa9\u304c\u65e9\u3044\u4eba<\/strong>\u3068<strong>\u9045\u3044\u4eba<\/strong>\u3067\u306f\u3001\u30ea\u30ab\u30d0\u30ea\u30fc\u30d7\u30e9\u30f3\u3092\u5909\u3048\u308b\u3053\u3068\u3067\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u56de\u5fa9\u304c\u65e9\u3044\u30bf\u30a4\u30d7\uff08IL6\u4f4e\u767a\u73fe &amp; CKM\u4f4e\u767a\u73fe\uff09<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u9031\u306b5\u301c6\u56de\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u3082\u9069\u5fdc\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li><strong>\u9ad8\u983b\u5ea6\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u53ef\u80fd<\/strong>\uff082\u65e5\u9023\u7d9a\u306e\u9ad8\u8ca0\u8377\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306a\u3069\uff09<\/li>\n\n\n\n<li><strong>\u30ea\u30ab\u30d0\u30ea\u30fc\u30bf\u30a4\u30e0\u3092\u77ed\u7e2e<\/strong>\u3057\u3001\u7a4d\u6975\u7684\u306a\u30b9\u30c8\u30ec\u30c3\u30c1\u3084\u30de\u30c3\u30b5\u30fc\u30b8\u3092\u6d3b\u7528<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u56de\u5fa9\u304c\u9045\u3044\u30bf\u30a4\u30d7\uff08IL6\u9ad8\u767a\u73fe &amp; CKM\u9ad8\u767a\u73fe\uff09<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f11\u606f\u65e5\u3092\u591a\u3081\u306b\u53d6\u308a\u3001\u90314\u56de\u7a0b\u5ea6\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u9069\u5207<\/li>\n\n\n\n<li><strong>EAA\uff08\u5fc5\u9808\u30a2\u30df\u30ce\u9178\uff09\u3092\u6d3b\u7528<\/strong>\u3057\u3001\u7b4b\u5408\u6210\u3092\u4fc3\u9032<\/li>\n\n\n\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u304c\u91cd\u8981<\/strong>\uff08\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u300c\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u300d\u306f\u7b4b\u8089\u306e\u56de\u5fa9\u3092\u59a8\u3052\u308b\u305f\u3081\u3001\u7791\u60f3\u3084\u547c\u5438\u6cd5\u3092\u53d6\u308a\u5165\u308c\u308b\uff09<\/li>\n<\/ul>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2462 \u907a\u4f1d\u5b50\u60c5\u5831\u306b\u57fa\u3065\u304f\u7761\u7720\u3068\u56de\u5fa9\u306e\u95a2\u4fc2<\/strong><\/h3>\n\n\n\n<p>\u7761\u7720\u306f\u7b4b\u8089\u306e\u56de\u5fa9\u306b\u304a\u3044\u3066\u6700\u3082\u91cd\u8981\u306a\u8981\u7d20\u306e\u4e00\u3064\u3067\u3059\u3002\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u3001<strong>\u7761\u7720\u306e\u8cea\u3084\u5fc5\u8981\u306a\u7761\u7720\u6642\u9593\u304c\u7570\u306a\u308b<\/strong>\u305f\u3081\u3001\u81ea\u5206\u306e\u907a\u4f1d\u7684\u7279\u6027\u306b\u5fdc\u3058\u305f\u7761\u7720\u6226\u7565\u3092\u53d6\u308b\u3053\u3068\u304c\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. CLOCK\u907a\u4f1d\u5b50\uff08\u6982\u65e5\u30ea\u30ba\u30e0\u3068\u7761\u7720\uff09<\/strong><\/h4>\n\n\n\n<p>CLOCK\u907a\u4f1d\u5b50\u306f\u3001\u4f53\u5185\u6642\u8a08\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001<strong>\u7761\u7720\u306e\u8cea\u3084\u671d\u578b\u30fb\u591c\u578b\u306e\u50be\u5411\u3092\u6c7a\u5b9a<\/strong>\u3057\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28913666\/\">Takahashi JS, 2017<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u671d\u578b\uff08CLOCK\u306e\u7279\u5b9a\u5909\u7570\u3042\u308a\uff09<\/strong> \u2192 \u671d\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u5411\u3044\u3066\u3044\u308b<\/li>\n\n\n\n<li><strong>\u591c\u578b\uff08CLOCK\u306e\u5909\u7570\u306a\u3057\uff09<\/strong> \u2192 \u591c\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u52b9\u679c\u7684<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7761\u7720\u6539\u5584\u6226\u7565<\/strong>\uff1a \u2705 <strong>\u671d\u578b\u306e\u4eba<\/strong> \u2192 \u5c31\u5bdd\u524d\u306b\u30ab\u30d5\u30a7\u30a4\u30f3\u3092\u63a7\u3048\u3001\u671d\u306e\u5149\u3092\u6d74\u3073\u308b\u3053\u3068\u3067\u4f53\u5185\u30ea\u30ba\u30e0\u3092\u6574\u3048\u308b<br>\u2705 <strong>\u591c\u578b\u306e\u4eba<\/strong> \u2192 \u591c\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306f\u30af\u30fc\u30eb\u30c0\u30a6\u30f3\u3092\u3057\u3063\u304b\u308a\u884c\u3044\u3001\u526f\u4ea4\u611f\u795e\u7d4c\u3092\u512a\u4f4d\u306b\u3059\u308b<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. BDNF\u907a\u4f1d\u5b50\uff08\u8133\u306e\u56de\u5fa9\u3068\u7761\u7720\u306e\u95a2\u4fc2\uff09<\/strong><\/h4>\n\n\n\n<p>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u4fee\u5fa9\u3084\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002BDNF\u306e\u767a\u73fe\u304c\u4f4e\u3044\u4eba\u306f\u3001<strong>\u30b9\u30c8\u30ec\u30b9\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u7761\u7720\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044<\/strong>\u50be\u5411\u304c\u3042\u308a\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22958817\/\">Rothman SM, 2012<\/a>\uff09\u3002<\/p>\n\n\n\n<p><strong>\u7761\u7720\u6226\u7565<\/strong>\uff1a \u2705 <strong>BDNF\u306e\u767a\u73fe\u304c\u4f4e\u3044\u4eba<\/strong> \u2192 \u5c31\u5bdd\u524d\u306b\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u3092\u6442\u53d6\u3057\u3001\u30ea\u30e9\u30c3\u30af\u30b9\u52b9\u679c\u3092\u9ad8\u3081\u308b<br>\u2705 <strong>BDNF\u306e\u767a\u73fe\u304c\u9ad8\u3044\u4eba<\/strong> \u2192 \u6df1\u3044\u7761\u7720\u3092\u4fc3\u3059\u305f\u3081\u306b\u3001\u4f4e\u97f3\u306e\u97f3\u697d\u3084\u30db\u30ef\u30a4\u30c8\u30ce\u30a4\u30ba\u3092\u6d3b\u7528<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2463 \u56de\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u6804\u990a\u6226\u7565<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31704580_m-1024x683.jpg\" alt=\"\u9b5a\u6599\u7406\u3000\u30ec\u30b9\u30c8\u30e9\u30f3\u306e\u6599\u7406\" class=\"wp-image-3467\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31704580_m-1024x683.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31704580_m-300x200.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31704580_m-768x512.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31704580_m-1536x1024.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31704580_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>\u7b4b\u56de\u5fa9\u3092\u65e9\u3081\u308b\u305f\u3081\u306b\u306f\u3001\u9069\u5207\u306a\u6804\u990a\u6442\u53d6\u304c\u4e0d\u53ef\u6b20<\/strong>\u3067\u3059\u3002\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u3001\u56de\u5fa9\u306e\u901f\u5ea6\u3084\u7b4b\u640d\u50b7\u306e\u5ea6\u5408\u3044\u306b\u5fdc\u3058\u305f\u6804\u990a\u6226\u7565\u3092\u53d6\u308a\u5165\u308c\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. \u9ad8\u708e\u75c7\u30ea\u30b9\u30af\u306e\u4eba\u5411\u3051\uff08IL6\u9ad8\u767a\u73fe\u30bf\u30a4\u30d7\uff09<\/strong><\/h4>\n\n\n\n<p>\u2705 **\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08EPA\u30fbDHA\uff09**\u3092\u6442\u53d6\u3057\u3001\u708e\u75c7\u3092\u6291\u3048\u308b<br>\u2705 **\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\uff08\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\u3001\u30ab\u30ab\u30aa\uff09**\u3092\u6d3b\u7528\u3057\u3001\u6297\u9178\u5316\u4f5c\u7528\u3092\u9ad8\u3081\u308b<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u7b4b\u640d\u50b7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u5411\u3051\uff08CKM\u9ad8\u767a\u73fe\u30bf\u30a4\u30d7\uff09<\/strong><\/h4>\n\n\n\n<p>\u2705 <strong>\u30af\u30ec\u30a2\u30c1\u30f3\u6442\u53d6\u3092\u6700\u9069\u5316<\/strong>\uff081\u65e55g\u6442\u53d6\u3067\u7b4b\u75b2\u52b4\u306e\u56de\u5fa9\u3092\u4fc3\u9032\uff09<br>\u2705 <strong>BCAA\u3092\u904b\u52d5\u524d\u5f8c\u306b\u6442\u53d6<\/strong>\u3057\u3001\u7b4b\u5206\u89e3\u3092\u9632\u3050<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>3. \u7761\u7720\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u305f\u3044\u4eba\u5411\u3051\uff08CLOCK &amp; BDNF\u95a2\u9023\uff09<\/strong><\/h4>\n\n\n\n<p>\u2705 <strong>\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\uff08\u30bb\u30ed\u30c8\u30cb\u30f3\u524d\u99c6\u4f53\uff09\u3092\u542b\u3080\u98df\u54c1<\/strong>\uff08\u30d0\u30ca\u30ca\u3001\u4e73\u88fd\u54c1\uff09\u3092\u6442\u53d6<br>\u2705 <strong>GABA\uff08\u30ea\u30e9\u30c3\u30af\u30b9\u52b9\u679c\u306e\u3042\u308b\u30a2\u30df\u30ce\u9178\uff09\u3092\u6442\u53d6<\/strong>\uff08\u767a\u9175\u98df\u54c1\u3001\u7dd1\u8336\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u7b4b\u56de\u5fa9\u3084\u7761\u7720\u306e\u8cea\u3092\u6700\u9069\u5316\u3057\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u52b9\u679c\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u306b\u306a\u308a\u307e\u3059\u3002\u907a\u4f1d\u7684\u306a\u7279\u6027\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u306b\u57fa\u3065\u3044\u305f\u56de\u5fa9\u6226\u7565\u3092\u53d6\u308a\u5165\u308c\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u7387\u7684\u306b\u7b4b\u8089\u3092\u6210\u9577\u3055\u305b\u3001\u9577\u671f\u7684\u306a\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u306b\u3064\u306a\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8. \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u500b\u5225\u6700\u9069\u5316<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u57fa\u306b\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6700\u9069\u5316\u306f\u3001\u5358\u306b\u7b4b\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u602a\u6211\u306e\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3057\u3001\u6301\u7d9a\u7684\u306a\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u3092\u5b9f\u73fe\u3059\u308b<\/strong>\u305f\u3081\u306e\u91cd\u8981\u306a\u624b\u6bb5\u3067\u3059\u3002\u907a\u4f1d\u7684\u306a\u8981\u56e0\u3092\u7406\u89e3\u3057\u3001\u305d\u308c\u306b\u5fdc\u3058\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30e1\u30cb\u30e5\u30fc\u3092\u69cb\u7bc9\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u7387\u7684\u306a\u30d5\u30a3\u30c3\u30c8\u30cd\u30b9\u6226\u7565\u3092\u7acb\u3066\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n<div class=\"custom-html\"><div class=\"category_btn btn_type_01\">\n <a href=\"https:\/\/www.generio.jp\/view\/category\/GC-CAR\" target=\"_blank\"><\/p>\n<div class=\"category_btn_inner\">\n<p class=\"ttl-txt\">\u672a\u6765\u3092\u77e5\u308b\u305f\u3081\u306e<span>\u6700\u65b0\u6280\u8853<\/span><\/p>\n<p class=\"btn\">\u3054\u8cfc\u5165\u306f\u3053\u3061\u3089<\/p>\n<\/p><\/div>\n<p> <\/a>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2460 \u602a\u6211\u306e\u30ea\u30b9\u30af\u3068\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h3>\n\n\n\n<p>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308b<strong>\u976d\u5e2f\u640d\u50b7\u3084\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u3082\u3001\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b<\/strong>\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u591a\u578b\u304c\u3001\u95a2\u7bc0\u306e\u67d4\u8edf\u6027\u3084\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u5f37\u5ea6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u30b9\u30dd\u30fc\u30c4\u969c\u5bb3\u306e\u767a\u751f\u7387\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. COL1A1\u907a\u4f1d\u5b50\uff08\u976d\u5e2f\u306e\u5f37\u5ea6\u3068\u67d4\u8edf\u6027\uff09<\/strong><\/h4>\n\n\n\n<p>COL1A1\uff08I\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u907a\u4f1d\u5b50\uff09\u306f\u3001<strong>\u976d\u5e2f\u3084\u8171\u306e\u5f37\u5ea6\u306b\u95a2\u4e0e\u3057\u3001\u30b9\u30dd\u30fc\u30c4\u50b7\u5bb3\u306e\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3059\u308b<\/strong>\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18184783\/\">Mannion AF, 2008<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u578b\uff08TT\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong> \u2192 \u976d\u5e2f\u304c\u67d4\u3089\u304b\u304f\u3001\u637b\u632b\u3084\u976d\u5e2f\u640d\u50b7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044<\/li>\n\n\n\n<li><strong>\u975e\u30ea\u30b9\u30af\u578b\uff08CC\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong> \u2192 \u976d\u5e2f\u304c\u5f37\u56fa\u3067\u3001\u95a2\u7bc0\u306e\u5b89\u5b9a\u6027\u304c\u9ad8\u3044<\/li>\n<\/ul>\n\n\n\n<p>\u2705 <strong>\u30ea\u30b9\u30af\u578b\u306e\u4eba\u5411\u3051\u306e\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30b9\u30c8\u30ec\u30c3\u30c1\u3092\u884c\u3044\u3059\u304e\u305a\u3001<strong>\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u95a2\u7bc0\u3092\u88dc\u5f37<\/strong>\u3059\u308b<\/li>\n\n\n\n<li>\u4f53\u5e79\uff08\u30b3\u30a2\uff09\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u53d6\u308a\u5165\u308c\u3001\u819d\u3084\u80a9\u306e\u5b89\u5b9a\u6027\u3092\u5411\u4e0a<\/li>\n\n\n\n<li>\u30b3\u30e9\u30fc\u30b2\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\uff08\u30bc\u30e9\u30c1\u30f3\u3001\u30d3\u30bf\u30df\u30f3C\uff09\u3092\u6442\u53d6\u3057\u3001\u7d44\u7e54\u306e\u56de\u5fa9\u3092\u4fc3\u9032<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. GDF5\u907a\u4f1d\u5b50\uff08\u95a2\u7bc0\u306e\u5065\u5eb7\u3068\u53ef\u52d5\u57df\uff09<\/strong><\/h4>\n\n\n\n<p>GDF5\uff08\u6210\u9577\u5206\u5316\u56e0\u5b505\uff09\u907a\u4f1d\u5b50\u306f\u3001<strong>\u95a2\u7bc0\u306e\u5f62\u6210\u3084\u8edf\u9aa8\u306e\u7dad\u6301\u306b\u95a2\u4e0e<\/strong>\u3057\u3001\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3084\u95a2\u7bc0\u53ef\u52d5\u57df\u306e\u9055\u3044\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18941479\/\">Chapman K, 2008<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GDF5\u306e\u30ea\u30b9\u30af\u5909\u7570\u3092\u6301\u3064\u4eba<\/strong> \u2192 \u95a2\u7bc0\u306e\u53ef\u52d5\u57df\u304c\u72ed\u304f\u3001\u904b\u52d5\u306b\u3088\u308b\u95a2\u7bc0\u75db\u3092\u8d77\u3053\u3057\u3084\u3059\u3044<\/li>\n\n\n\n<li><strong>\u975e\u30ea\u30b9\u30af\u578b\u306e\u4eba<\/strong> \u2192 \u67d4\u8edf\u6027\u304c\u9ad8\u304f\u3001\u52d5\u304d\u306e\u81ea\u7531\u5ea6\u304c\u5e83\u3044<\/li>\n<\/ul>\n\n\n\n<p>\u2705 <strong>\u30ea\u30b9\u30af\u578b\u306e\u4eba\u5411\u3051\u306e\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30a6\u30a9\u30fc\u30e0\u30a2\u30c3\u30d7\u3092\u5fb9\u5e95<\/strong>\u3057\u3001\u95a2\u7bc0\u3092\u5341\u5206\u306b\u6e29\u3081\u3066\u304b\u3089\u904b\u52d5\u3092\u958b\u59cb<\/li>\n\n\n\n<li><strong>\u30d5\u30a9\u30fc\u30e0\u30ed\u30fc\u30ea\u30f3\u30b0\u3084\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u30b9\u30c8\u30ec\u30c3\u30c1<\/strong>\u3092\u53d6\u308a\u5165\u308c\u3001\u95a2\u7bc0\u306e\u52d5\u304d\u3092\u6ed1\u3089\u304b\u306b<\/li>\n\n\n\n<li><strong>\u6297\u708e\u75c7\u98df\u54c1\uff08\u30bf\u30fc\u30e1\u30ea\u30c3\u30af\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff09\u3092\u6442\u53d6<\/strong>\u3057\u3001\u95a2\u7bc0\u306e\u5065\u5eb7\u3092\u7dad\u6301<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2461 \u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3057\u305f\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u5411\u4e0a<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-1024x574.jpg\" alt=\"\u9678\u4e0a\uff13\" class=\"wp-image-4698\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-1024x574.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-300x168.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-768x431.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m-1536x862.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2025\/01\/31612512_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u907a\u4f1d\u5b50\u306e\u5f71\u97ff\u306f\u3001\u7b4b\u529b\u3084\u6301\u4e45\u529b\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u904b\u52d5\u795e\u7d4c\u306e\u767a\u9054\u3084\u77ac\u767a\u529b\u306e\u767a\u63ee<\/strong>\u306b\u3082\u53ca\u3073\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7279\u6027\u3092\u6d3b\u304b\u3057\u3066\u3001\u30b9\u30dd\u30fc\u30c4\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u3092\u76ee\u6307\u3059\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. BDNF\u907a\u4f1d\u5b50\uff08\u904b\u52d5\u5b66\u7fd2\u3068\u795e\u7d4c\u9069\u5fdc\uff09<\/strong><\/h4>\n\n\n\n<p>BDNF\uff08\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u907a\u4f1d\u5b50\u306f\u3001<strong>\u904b\u52d5\u5b66\u7fd2\u3084\u795e\u7d4c\u9069\u5fdc\u306b\u95a2\u4e0e\u3057\u3001\u65b0\u3057\u3044\u52d5\u4f5c\u3092\u7fd2\u5f97\u3059\u308b\u901f\u5ea6\u306b\u5f71\u97ff<\/strong>\u3092\u4e0e\u3048\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22029387\/\">Hopkins ME, 2012<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BDNF\u306e\u9ad8\u767a\u73fe\u578b\u306e\u4eba<\/strong> \u2192 \u904b\u52d5\u306e\u7fd2\u5f97\u304c\u65e9\u304f\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u9069\u5fdc\u304c\u30b9\u30e0\u30fc\u30ba<\/li>\n\n\n\n<li><strong>BDNF\u306e\u4f4e\u767a\u73fe\u578b\u306e\u4eba<\/strong> \u2192 \u65b0\u3057\u3044\u904b\u52d5\u30b9\u30ad\u30eb\u3092\u8eab\u306b\u3064\u3051\u308b\u306e\u306b\u6642\u9593\u304c\u304b\u304b\u308b<\/li>\n<\/ul>\n\n\n\n<p>\u2705 <strong>BDNF\u4f4e\u767a\u73fe\u578b\u306e\u4eba\u5411\u3051\u306e\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u795e\u7d4c\u7cfb\u3092\u935b\u3048\u308b\u30c9\u30ea\u30eb<\/strong>\uff08\u30b3\u30fc\u30c7\u30a3\u30cd\u30fc\u30b7\u30e7\u30f3\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3001\u30d0\u30e9\u30f3\u30b9\u904b\u52d5\uff09\u3092\u591a\u304f\u53d6\u308a\u5165\u308c\u308b<\/li>\n\n\n\n<li><strong>\u9069\u5ea6\u306a\u6709\u9178\u7d20\u904b\u52d5<\/strong>\uff08\u30e9\u30f3\u30cb\u30f3\u30b0\u3001\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\uff09\u3067BDNF\u306e\u5206\u6ccc\u3092\u4fc3\u9032<\/li>\n\n\n\n<li><strong>DHA\uff08\u30aa\u30e1\u30ac3\uff09\u3092\u6442\u53d6\u3057\u3001\u795e\u7d4c\u7d30\u80de\u306e\u53ef\u5851\u6027\u3092\u5411\u4e0a<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. SLC6A4\u907a\u4f1d\u5b50\uff08\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3068\u8a66\u5408\u4e2d\u306e\u30e1\u30f3\u30bf\u30eb\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff09<\/strong><\/h4>\n\n\n\n<p>SLC6A4\u907a\u4f1d\u5b50\u306f\u3001<strong>\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u8f38\u9001\u3092\u5236\u5fa1\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3084\u96c6\u4e2d\u529b\u306b\u5f71\u97ff<\/strong>\u3092\u4e0e\u3048\u307e\u3059\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12376585\/\">Hariri AR, 2002<\/a>\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ea\u30b9\u30af\u578b\uff08S\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong> \u2192 \u30d7\u30ec\u30c3\u30b7\u30e3\u30fc\u306e\u304b\u304b\u308b\u5834\u9762\u3067\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u3084\u3059\u3044<\/li>\n\n\n\n<li><strong>\u975e\u30ea\u30b9\u30af\u578b\uff08L\u578b\uff09\u3092\u6301\u3064\u4eba<\/strong> \u2192 \u7cbe\u795e\u7684\u306b\u5b89\u5b9a\u3057\u3001\u8a66\u5408\u4e2d\u306e\u30d7\u30ec\u30c3\u30b7\u30e3\u30fc\u306b\u5f37\u3044<\/li>\n<\/ul>\n\n\n\n<p>\u2705 <strong>\u30ea\u30b9\u30af\u578b\u306e\u4eba\u5411\u3051\u306e\u5bfe\u7b56<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30de\u30a4\u30f3\u30c9\u30d5\u30eb\u30cd\u30b9\u7791\u60f3\u3084\u547c\u5438\u6cd5<\/strong>\u3092\u7fd2\u6163\u5316\u3057\u3001\u8a66\u5408\u524d\u306e\u7dca\u5f35\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/li>\n\n\n\n<li><strong>\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u3092\u591a\u304f\u542b\u3080\u98df\u54c1<\/strong>\uff08\u30ca\u30c3\u30c4\u3001\u30d0\u30ca\u30ca\uff09\u3092\u6442\u53d6\u3057\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u3092\u4fc3\u3059<\/li>\n\n\n\n<li><strong>\u8a66\u5408\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3084\u30e1\u30f3\u30bf\u30eb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0<\/strong>\u3092\u7a4d\u6975\u7684\u306b\u53d6\u308a\u5165\u308c\u3001\u30d7\u30ec\u30c3\u30b7\u30e3\u30fc\u306b\u6163\u308c\u308b<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u2462 \u907a\u4f1d\u5b50\u60c5\u5831\u3068\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u672a\u6765<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"585\" src=\"\/gene\/wp-content\/uploads\/2024\/12\/31102401_m-1024x585.jpg\" alt=\"\u8d70\u308b\u3000\u8db3\u5143\" class=\"wp-image-3751\" srcset=\"https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31102401_m-1024x585.jpg 1024w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31102401_m-300x171.jpg 300w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31102401_m-768x439.jpg 768w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31102401_m-1536x878.jpg 1536w, https:\/\/www.hiro-clinic.or.jp\/gene\/wp-content\/uploads\/2024\/12\/31102401_m.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u8fd1\u5e74\u3001AI\u6280\u8853\u3068\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u305f**\u300c\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u300d**\u306e\u958b\u767a\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1. AI\u306b\u3088\u308b\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u89e3\u6790<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u904b\u52d5\u5c65\u6b74\u3092\u7d44\u307f\u5408\u308f\u305b\u3001<strong>\u500b\u5225\u6700\u9069\u5316\u3055\u308c\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u4f5c\u6210<\/strong><\/li>\n\n\n\n<li>\u30a6\u30a7\u30a2\u30e9\u30d6\u30eb\u30c7\u30d0\u30a4\u30b9\u3068\u9023\u643a\u3057\u3001<strong>\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u904b\u52d5\u5f37\u5ea6\u3084\u56de\u5fa9\u5ea6\u3092\u8abf\u6574<\/strong><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. \u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u53ef\u80fd\u6027<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>CRISPR\u6280\u8853\u3092\u7528\u3044\u305f\u7b4b\u529b\u5f37\u5316\u306e\u7814\u7a76<\/strong>\u304c\u9032\u884c\u4e2d<\/li>\n\n\n\n<li>\u5c06\u6765\u7684\u306b\u306f\u3001<strong>\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u3067\u7b4b\u8089\u3084\u6301\u4e45\u529b\u3092\u5f37\u5316\u3059\u308b\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u308b\u53ef\u80fd\u6027<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u602a\u6211\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3057\u3001\u7b4b\u529b\u3084\u6301\u4e45\u529b\u3092\u6700\u5927\u5316\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u53ef\u80fd<\/strong>\u3067\u3059\u3002\u6700\u65b0\u306e\u7814\u7a76\u3084\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u4eca\u5f8c\u3055\u3089\u306b\u9ad8\u5ea6\u306a\u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u30c9\u30fb\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u304c\u5b9f\u73fe\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u53d6\u308a\u5165\u308c\u3001\u907a\u4f1d\u7684\u7279\u6027\u3092\u6700\u5927\u9650\u306b\u6d3b\u304b\u3057\u305f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u6226\u7565\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u30d5\u30a3\u30c3\u30c8\u30cd\u30b9\u3068\u5065\u5eb7\u7dad\u6301\u3092\u76ee\u6307\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u307e\u3068\u3081<\/strong><\/h3>\n\n\n\n<p>\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001<strong>\u7b4b\u529b\u30fb\u6301\u4e45\u529b\u306e\u5411\u4e0a\u3001\u30ea\u30ab\u30d0\u30ea\u30fc\u306e\u6700\u9069\u5316\u3001\u602a\u6211\u306e\u30ea\u30b9\u30af\u7ba1\u7406\u3001\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u5411\u4e0a<\/strong>\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<strong>ACTN3\u3001MSTN\u3001ACE\u3001COL1A1\u306a\u3069\u306e\u907a\u4f1d\u5b50<\/strong>\u304c\u7b4b\u7dda\u7dad\u306e\u30bf\u30a4\u30d7\u3084\u56de\u5fa9\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304a\u308a\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3084\u6804\u990a\u6226\u7565\u3092\u907a\u4f1d\u7684\u7279\u6027\u306b\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u7387\u7684\u306a\u7d50\u679c\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<strong>AI\u3084\u907a\u4f1d\u5b50\u7de8\u96c6\u6280\u8853\u306e\u9032\u5316<\/strong>\u306b\u3088\u308a\u3001\u4eca\u5f8c\u306f\u3055\u3089\u306b\u7cbe\u5bc6\u306a\u500b\u5225\u6700\u9069\u5316\u304c\u5b9f\u73fe\u3059\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n<div 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